NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489178278|ref|WP_003087788|]
View 

MULTISPECIES: helix-turn-helix transcriptional regulator [Pseudomonas]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11458467)

helix-turn-helix transcriptional regulator similar to HTH-type transcriptional regulator MalT regulates transcription of the maltose regulon and thus the uptake and catabolism of malto-oligosaccharides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK04841 super family cl35271
HTH-type transcriptional regulator MalT;
13-901 2.82e-62

HTH-type transcriptional regulator MalT;


The actual alignment was detected with superfamily member PRK04841:

Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 227.52  E-value: 2.82e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  13 PLLQTKLFPPGAGGlPLLPRQALIDRLYEARGRRAMVLSAPAGFGKSTILCQlrlRLLEQgAAVAWLSCDETDSEPQRLI 92
Cdd:PRK04841   1 MLIPSKLSRPVRLH-NTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQ---WAAGK-NNLGWYSLDESDNQPERFA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  93 QYLLASIQRVVPAFGGNTANLLGTDVAVPLEGILDAFLADLRRLEGPLYLFLDDFHRIRHAALPHGVRYLIENLPDHVRV 172
Cdd:PRK04841  76 SYLIAALQQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 173 VASTRFRPRFLVDEPTLKPWTFCLSAEDLRLSREESDAFLLDLKGLELGERELKLLFKRTEGWITALH--LAALALSRNT 250
Cdd:PRK04841 156 VVLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQliALSARQNNSS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 251 DREGFLRGLSGTERNIADYLAEDVLASLPADLQLFLDQTSVLDEFNAELCNALTGRRDGLDMLMRLQNEQLFVIALDDQR 330
Cdd:PRK04841 236 LHDSARRLAGINASHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 331 EWFRYHHLFAEFLQGRLS-RHADPTPLLH-AAARWCEGRDLADRAIKYALRARDYLFAAELLERQGARLIAGNRVYGILG 408
Cdd:PRK04841 316 EWFRYHPLFASFLRHRCQwELAQELPELHrAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 409 MLNGIPAEVIREHPVFQIFYAWqLAFEQ-RFAEAEALIEEVSHRlLQGRGKVMHfglGELLAAAQVLKALVLLYQDKLEA 487
Cdd:PRK04841 396 CLNALPWEVLLENPRLVLLQAW-LAQSQhRYSEVNTLLARAEQE-LKDRNIELD---GTLQAEFNALRAQVAINDGDPEE 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 488 CLKVARHWLSMVPSNQPVFRASLLCVQASAHALLGDYAEAAGAIGSArEDLKVADSEYLQVVTSLIE-SLICKESGDLER 566
Cdd:PRK04841 471 AERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQT-EQMARQHDVYHYALWSLLQqSEILFAQGFLQA 549

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 567 GRAIAESA-----RNRVEQV----FGRRSRvggplslayADLLY--------EQDRHAG--VLAE------LPLATVWRD 621
Cdd:PRK04841 550 AYETQEKAfqlieEQHLEQLpmheFLLRIR---------AQLLWewarldeaEQCARKGleVLSNyqpqqqLQCLAMLAK 620

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 622 VAtpvelLSRGQLvmAKARFFSGAAEQGLAQLD---EWLsgllspgyervyahAMSCKVQFLLW-LRRPNEAERVCL-QL 696
Cdd:PRK04841 621 IS-----LARGDL--DNARRYLNRLENLLGNGRyhsDWI--------------ANADKVRLIYWqMTGDKEAAANWLrQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 697 ER------HLAGLSGERHADAQTAL-VLAEARLALSERHAERAQSKLESCLagyssayQRDrrlrlSLLLSVAYWQKGNS 769
Cdd:PRK04841 680 PKpefannHFLQGQWRNIARAQILLgQFDEAEIILEELNENARSLRLMSDL-------NRN-----LILLNQLYWQQGRK 747

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 770 EKAIGLFLATLEEAWNLG---------------YRRLFQDDALwllpmweswREAEPKRAaawQGLADLLREQCRKLSVd 834
Cdd:PRK04841 748 SEAQRVLLEALKLANRTGfishfviegeamaqqLRQLIQLNTL---------PELEQHRA---QRILREINQHHRHKFA- 814

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 835 peSFDEN--------QDV---------SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLK 897
Cdd:PRK04841 815 --HFDEAfvekllnhPDVpelirtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 489178278 898 GKSL 901
Cdd:PRK04841 893 AQDL 896
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
13-901 2.82e-62

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 227.52  E-value: 2.82e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  13 PLLQTKLFPPGAGGlPLLPRQALIDRLYEARGRRAMVLSAPAGFGKSTILCQlrlRLLEQgAAVAWLSCDETDSEPQRLI 92
Cdd:PRK04841   1 MLIPSKLSRPVRLH-NTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQ---WAAGK-NNLGWYSLDESDNQPERFA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  93 QYLLASIQRVVPAFGGNTANLLGTDVAVPLEGILDAFLADLRRLEGPLYLFLDDFHRIRHAALPHGVRYLIENLPDHVRV 172
Cdd:PRK04841  76 SYLIAALQQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 173 VASTRFRPRFLVDEPTLKPWTFCLSAEDLRLSREESDAFLLDLKGLELGERELKLLFKRTEGWITALH--LAALALSRNT 250
Cdd:PRK04841 156 VVLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQliALSARQNNSS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 251 DREGFLRGLSGTERNIADYLAEDVLASLPADLQLFLDQTSVLDEFNAELCNALTGRRDGLDMLMRLQNEQLFVIALDDQR 330
Cdd:PRK04841 236 LHDSARRLAGINASHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 331 EWFRYHHLFAEFLQGRLS-RHADPTPLLH-AAARWCEGRDLADRAIKYALRARDYLFAAELLERQGARLIAGNRVYGILG 408
Cdd:PRK04841 316 EWFRYHPLFASFLRHRCQwELAQELPELHrAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 409 MLNGIPAEVIREHPVFQIFYAWqLAFEQ-RFAEAEALIEEVSHRlLQGRGKVMHfglGELLAAAQVLKALVLLYQDKLEA 487
Cdd:PRK04841 396 CLNALPWEVLLENPRLVLLQAW-LAQSQhRYSEVNTLLARAEQE-LKDRNIELD---GTLQAEFNALRAQVAINDGDPEE 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 488 CLKVARHWLSMVPSNQPVFRASLLCVQASAHALLGDYAEAAGAIGSArEDLKVADSEYLQVVTSLIE-SLICKESGDLER 566
Cdd:PRK04841 471 AERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQT-EQMARQHDVYHYALWSLLQqSEILFAQGFLQA 549

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 567 GRAIAESA-----RNRVEQV----FGRRSRvggplslayADLLY--------EQDRHAG--VLAE------LPLATVWRD 621
Cdd:PRK04841 550 AYETQEKAfqlieEQHLEQLpmheFLLRIR---------AQLLWewarldeaEQCARKGleVLSNyqpqqqLQCLAMLAK 620

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 622 VAtpvelLSRGQLvmAKARFFSGAAEQGLAQLD---EWLsgllspgyervyahAMSCKVQFLLW-LRRPNEAERVCL-QL 696
Cdd:PRK04841 621 IS-----LARGDL--DNARRYLNRLENLLGNGRyhsDWI--------------ANADKVRLIYWqMTGDKEAAANWLrQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 697 ER------HLAGLSGERHADAQTAL-VLAEARLALSERHAERAQSKLESCLagyssayQRDrrlrlSLLLSVAYWQKGNS 769
Cdd:PRK04841 680 PKpefannHFLQGQWRNIARAQILLgQFDEAEIILEELNENARSLRLMSDL-------NRN-----LILLNQLYWQQGRK 747

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 770 EKAIGLFLATLEEAWNLG---------------YRRLFQDDALwllpmweswREAEPKRAaawQGLADLLREQCRKLSVd 834
Cdd:PRK04841 748 SEAQRVLLEALKLANRTGfishfviegeamaqqLRQLIQLNTL---------PELEQHRA---QRILREINQHHRHKFA- 814

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 835 peSFDEN--------QDV---------SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLK 897
Cdd:PRK04841 815 --HFDEAfvekllnhPDVpelirtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 489178278 898 GKSL 901
Cdd:PRK04841 893 AQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 845-905 6.59e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 86.48  E-value: 6.59e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178278 845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLLS 905
Cdd:COG2197   71 TPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 845-897 1.47e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.96  E-value: 1.47e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 489178278   845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLK 897
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRL 57
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 845-900 4.80e-18

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 78.73  E-value: 4.80e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489178278 845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKS 900
Cdd:cd06170    2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
845-895 7.10e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 72.62  E-value: 7.10e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489178278  845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAV 895
Cdd:pfam00196   4 SPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
13-901 2.82e-62

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 227.52  E-value: 2.82e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  13 PLLQTKLFPPGAGGlPLLPRQALIDRLYEARGRRAMVLSAPAGFGKSTILCQlrlRLLEQgAAVAWLSCDETDSEPQRLI 92
Cdd:PRK04841   1 MLIPSKLSRPVRLH-NTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQ---WAAGK-NNLGWYSLDESDNQPERFA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  93 QYLLASIQRVVPAFGGNTANLLGTDVAVPLEGILDAFLADLRRLEGPLYLFLDDFHRIRHAALPHGVRYLIENLPDHVRV 172
Cdd:PRK04841  76 SYLIAALQQATNGHCSKSEALAQKRQYASLSSLFAQLFIELADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 173 VASTRFRPRFLVDEPTLKPWTFCLSAEDLRLSREESDAFLLDLKGLELGERELKLLFKRTEGWITALH--LAALALSRNT 250
Cdd:PRK04841 156 VVLSRNLPPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQliALSARQNNSS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 251 DREGFLRGLSGTERNIADYLAEDVLASLPADLQLFLDQTSVLDEFNAELCNALTGRRDGLDMLMRLQNEQLFVIALDDQR 330
Cdd:PRK04841 236 LHDSARRLAGINASHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSG 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 331 EWFRYHHLFAEFLQGRLS-RHADPTPLLH-AAARWCEGRDLADRAIKYALRARDYLFAAELLERQGARLIAGNRVYGILG 408
Cdd:PRK04841 316 EWFRYHPLFASFLRHRCQwELAQELPELHrAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 409 MLNGIPAEVIREHPVFQIFYAWqLAFEQ-RFAEAEALIEEVSHRlLQGRGKVMHfglGELLAAAQVLKALVLLYQDKLEA 487
Cdd:PRK04841 396 CLNALPWEVLLENPRLVLLQAW-LAQSQhRYSEVNTLLARAEQE-LKDRNIELD---GTLQAEFNALRAQVAINDGDPEE 470

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 488 CLKVARHWLSMVPSNQPVFRASLLCVQASAHALLGDYAEAAGAIGSArEDLKVADSEYLQVVTSLIE-SLICKESGDLER 566
Cdd:PRK04841 471 AERLAELALAELPLTWYYSRIVATSVLGEVHHCKGELARALAMMQQT-EQMARQHDVYHYALWSLLQqSEILFAQGFLQA 549

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 567 GRAIAESA-----RNRVEQV----FGRRSRvggplslayADLLY--------EQDRHAG--VLAE------LPLATVWRD 621
Cdd:PRK04841 550 AYETQEKAfqlieEQHLEQLpmheFLLRIR---------AQLLWewarldeaEQCARKGleVLSNyqpqqqLQCLAMLAK 620

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 622 VAtpvelLSRGQLvmAKARFFSGAAEQGLAQLD---EWLsgllspgyervyahAMSCKVQFLLW-LRRPNEAERVCL-QL 696
Cdd:PRK04841 621 IS-----LARGDL--DNARRYLNRLENLLGNGRyhsDWI--------------ANADKVRLIYWqMTGDKEAAANWLrQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 697 ER------HLAGLSGERHADAQTAL-VLAEARLALSERHAERAQSKLESCLagyssayQRDrrlrlSLLLSVAYWQKGNS 769
Cdd:PRK04841 680 PKpefannHFLQGQWRNIARAQILLgQFDEAEIILEELNENARSLRLMSDL-------NRN-----LILLNQLYWQQGRK 747

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 770 EKAIGLFLATLEEAWNLG---------------YRRLFQDDALwllpmweswREAEPKRAaawQGLADLLREQCRKLSVd 834
Cdd:PRK04841 748 SEAQRVLLEALKLANRTGfishfviegeamaqqLRQLIQLNTL---------PELEQHRA---QRILREINQHHRHKFA- 814

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 835 peSFDEN--------QDV---------SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLK 897
Cdd:PRK04841 815 --HFDEAfvekllnhPDVpelirtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 489178278 898 GKSL 901
Cdd:PRK04841 893 AQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 845-905 6.59e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 86.48  E-value: 6.59e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178278 845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLLS 905
Cdd:COG2197   71 TPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 845-897 1.47e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.96  E-value: 1.47e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 489178278   845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLK 897
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRL 57
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 845-905 2.33e-18

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 80.00  E-value: 2.33e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178278 845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLLS 905
Cdd:COG5905   14 TKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLLS 74
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 845-900 4.80e-18

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 78.73  E-value: 4.80e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489178278 845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKS 900
Cdd:cd06170    2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
845-895 7.10e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 72.62  E-value: 7.10e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489178278  845 SHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAV 895
Cdd:pfam00196   4 SPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
853-905 1.93e-13

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 69.73  E-value: 1.93e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489178278 853 RLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLLS 905
Cdd:COG2909  132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLLA 184
PRK10100 PRK10100
transcriptional regulator CsgD;
840-895 4.76e-13

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 69.13  E-value: 4.76e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489178278 840 ENQDVSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAV 895
Cdd:PRK10100 152 ESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAV 207
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
748-904 1.96e-10

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 60.92  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 748 QRDRRLRLSLLLSVAYWQKGNSEKAIGLFLATLEEAWNLGYRRLFQDDALWLLPMWESWREAEPKRAAAWQGLADLLREQ 827
Cdd:COG2771   32 LLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLLALALA 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489178278 828 CRKLSVDPESFDENQDVSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLL 904
Cdd:COG2771  112 ALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 820-894 3.71e-10

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 60.81  E-value: 3.71e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178278 820 LADLLREQCRKLSVDPESFDEnqdvshREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQA 894
Cdd:PRK10651 138 LAASLRANRATTERDVNQLTP------RERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 804-895 8.97e-10

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 58.96  E-value: 8.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 804 ESWREAEPKRAAAWQGLADLlreqcrklsvdpesfdenqdvSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLF 883
Cdd:COG4566  119 RARRAERARRAELRARLASL---------------------TPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVM 177

                         90
                 ....*....|..
gi 489178278 884 AKLGVKSRTQAV 895
Cdd:COG4566  178 EKLGARSLAELV 189
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
821-896 2.30e-08

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 55.63  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 821 ADLLREQCRKLSVDPESFDENQD----VSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVL 896
Cdd:PRK10403 127 SKVFSERVNQYLREREMFGAEEDpfsvLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATI 206
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
142-235 2.85e-07

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 51.63  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278 142 LFLDDFHRIRHAALphgvRYLIENLPDHVRVVASTRFRP--RFLVDEPtlkpwtfcLSAEDLRlsREESDAFLLDLkGLE 219
Cdd:COG2909    2 LVLDDYHLIDDIHL----AFLLRHLPPNLHLVLASRTDPlaRLRARLE--------LRADDLR--REEAAALLRRR-LLP 66

                         90
                 ....*....|....*.
gi 489178278 220 LGERELKLLFKRTEGW 235
Cdd:COG2909   67 LSEEDAARLAERTEGW 82
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
844-904 3.64e-07

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 51.80  E-value: 3.64e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178278 844 VSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLL 904
Cdd:PRK09935 150 LSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 32-155 1.71e-06

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 49.04  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278   32 RQALIDRLYEARGR------RAMVLSAPAGFGKSTILCQLRLRLLEQGAAVAWLSCD---------ETDSEPQRLIQYLL 96
Cdd:pfam13191   5 REEELEQLLDALDRvrsgrpPSVLLTGEAGTGKTTLLRELLRALERDGGYFLRGKCDenlpyspllEALTREGLLRQLLD 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178278   97 ASIQRVVPAFGGNTANLLGTDVAVPLEG------ILDAFLADLRRLEGPLYLFLDDFHRIRHAAL 155
Cdd:pfam13191  85 ELESSLLEAWRAALLEALAPVPELPGDLaerlldLLLRLLDLLARGERPLVLVLDDLQWADEASL 149
PRK15369 PRK15369
two component system response regulator;
847-904 3.83e-06

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 48.92  E-value: 3.83e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489178278 847 REREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKSRTQAVLKGKSLGLL 904
Cdd:PRK15369 153 RERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 469-801 2.16e-05

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 47.69  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  469 AAAQVLKALVLLYQDKLEACLKVARHWLSMVPSNQPVFRASLLCVQASAHALLGDYAEAAGAIGSAREDLKVADSEYLQV 548
Cdd:pfam17874   1 GEIAALRAQLAISKGDAERALELAEQALALLPEDDLLARGLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  549 VTSLIESLICKESGDLERGRAIAESARNRVEQVFGRRSRVGGPLSLAYADLLYEQDRHAGVLAELPLAtvwrdvatpVEL 628
Cdd:pfam17874  81 WALLQQGEILRAQGRLHQALETYQQALQLARDHGLQHLPLHGFLLVGLADLLYEWNDLEEAEQHAQQG---------IQL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  629 LSRGQ--------LVMAKARFFSGAAEQGLAQLDEwLSGLLSPGYERVYAHAMSCKVQFLLWLRRpNEAERVCLQLERHL 700
Cdd:pfam17874 152 GRQWEpdaavdayVLLARIALAQGELEEALTLLRR-AELLARQSFFHVDWLANAERVRVRLWLAR-GDLRAAVRWLRAAE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  701 AGLSGERHADAQTALVLAEARLALSerHAERAQSKLESCLAGYSSAYQRDRRLRLSLLLSVAYWQKGNSEKAIGLFLATL 780
Cdd:pfam17874 230 PPSDADNHFLERELRNLARVLLALG--RFDDALSLLERLQNLAEQLGRVRSLIENLILQALALLALGRPDEALQALLDAL 307

                         330       340
                  ....*....|....*....|.
gi 489178278  781 EEAWNLGYRRLFQDDALWLLP 801
Cdd:pfam17874 308 SLAEPEGYVRSFVDEGAPLAR 328
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 134-672 1.92e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 42.17  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  134 RRLEGPLYlfldDFHRIRHAALPHGVRYLIENLPDHVRVVASTRFRPRFLVDEPTLKPWTFCLSAEDLRLSREESDAFLL 213
Cdd:COG3321   859 RRVPLPTY----PFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVA 934

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  214 DLKGLELGERELKLLFKRTEGWITALHLAALALSRNTDREGFLRGLSGTERNIADYLAEDVLASLPADLQLFLDQTSVLD 293
Cdd:COG3321   935 LAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAA 1014

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  294 EFNAELCNALTGRRDGLDMLMRLQNEQLFVIALDDQREWFRYHHLFAEFLQGRLSRHADPTPLLHAAARWCEGRDLADRA 373
Cdd:COG3321  1015 AAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAA 1094

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  374 IKYALRARDYLFAAELLERQGARLIAGNRVYGILGMLNGIPAEVIREHPVFQIFYAWQLAFEQRFAEAEALIEEVSHRLL 453
Cdd:COG3321  1095 LALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALL 1174

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  454 QGRGKVMHFGLGELLAAAQVLKALVLLyqdkleaclkVARHWLSMVPSNQPVFRASLLCVQASAHALLGDYAEAAGAIGS 533
Cdd:COG3321  1175 LALALALAAALAAALAGLAALLLAALL----------AALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAA 1244

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  534 AREDLKVADSEYLQVVTSLIESLICKESGDLERGRAIAESARNRVEQVFGRRSRVGGPLSLAYADLLYEQDRHAGVLAEL 613
Cdd:COG3321  1245 VAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAA 1324

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489178278  614 PLATVWRDVATPVELLSRGQLVMAKARFFSGAAEQGLAQLDEWLSGLLSPGYERVYAHA 672
Cdd:COG3321  1325 LLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAA 1383
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 838-890 2.84e-03

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 40.11  E-value: 2.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489178278 838 FDENQDVSHREREILRLVAAGLSNRDIAQAVHLSEATIKWHLHNLFAKLGVKS 890
Cdd:PRK11475 129 INQSRMLSPTEREILRFMSRGYSMPQIAEQLERNIKTIRAHKFNVMSKLGVSS 181
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
848-882 2.89e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 36.26  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 489178278  848 EREILRLVA--AGLSNRDIAQAVHLSEATIKWHLHNL 882
Cdd:pfam13412   3 DRKILNLLQenPRISQRELAERLGLSPSTVNRRLKRL 39
COG3899 COG3899
Predicted ATPase [General function prediction only];
41-873 4.96e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 40.61  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278   41 EARGRRAMVLSAPAGFGKSTILCQLRLRLLEQGAAVAWLSCDETDSE-----------------PQRLIQYLLASIQRVV 103
Cdd:COG3899   307 RAGRGELVLVSGEAGIGKSRLVRELARRARARGGRVLRGKCDQLERGvpyaplaqalrallgqlPEDELAAWRARLLAAL 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  104 PAFGGNTANLLGTDVAVPLEG----------ILDAFLADLRRL--EGPLYLFLDDFHRIRHAALpHGVRYLIENLPD-HV 170
Cdd:COG3899   387 GANGRLLADLLPELELQPAPPeldpeearnrLFRALLRLLRALaaERPLVLVLDDLHWADPASL-ELLEFLLRRLRDlPL 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  171 RVVASTR--FRPRFLVDEPTLKPWTFCLSAEDL----RLSREESDAFLLDLKGLELGEREL-KLLFKRTEG------WIT 237
Cdd:COG3899   466 LLVGTYRpeEVPPAHPLRLLLAELRRAGAGVTRlelgPLSREEVAALVADLLGAAELPAELaELLVERTGGnpffleELL 545

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  238 ALHLAALALSRNTDREGFLRGLSGTE--RNIADyLAEDVLASLPADLQLFLDQTSVL-DEFNAELCNALTGRRDG--LDM 312
Cdd:COG3899   546 RALLEEGLLRFDGGGWRWDAALAALAlpDTVVD-LLAARLDRLPPAARRVLRLAAVLgRRFDLELLAAVLGLSEAelAAA 624

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  313 LMRLQNEQLFVIALDDQREWFRYHH-LFAEFLQGRLSRHAdpTPLLH-AAARWCEGRDLADRAIKYALRARDYLFAAELL 390
Cdd:COG3899   625 LEELVAAGLLVPRGDAGGGRYRFRHdLVREAAYASLPPEE--RRALHrRIARALEARGPEPLEERLFELAHHLNRAGERD 702

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  391 ERQGARLIAGNRVYGilgmlngipaevirehpvfqifyawQLAFEQRFAEAEALIEEVSHRLLQGRGKVMHFGLGELLAA 470
Cdd:COG3899   703 RAARLLLRAARRALA-------------------------RGAYAEALRYLERALELLPPDPEEEYRLALLLELAEALYL 757

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  471 AQVLKALVLLYQDKLEACLKVARHWLSMVPSnqpvfRASLLCVQASAHALLGDYAEAAGAIGSAREDLKVADSEYLQVVT 550
Cdd:COG3899   758 AGRFEEAEALLERALAARALAALAALRHGNP-----PASARAYANLGLLLLGDYEEAYEFGELALALAERLGDRRLEARA 832

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  551 SLIESLICKESGDLERGRAIAESARNRVEQVFGRRSRVGGPLSLAYADllyEQDRHAGVLAELPLATVWRDVATPVELLS 630
Cdd:COG3899   833 LFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAA---AAAAALAAAAAAAARLLAAAAAALAAAAA 909

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  631 RGQLVMAKARFFSGAAEQGLAQLDEWLSGLLSPGYERVYAHAMSCKVQFLLWLRRPNEAERVCLQLERHLAGLSGERHAD 710
Cdd:COG3899   910 AAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAA 989

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  711 AQTALVLAEARLALSERHAERAQSKLESCLAGYSSAYQRDRRLRLSLLLSVAYWQKGNSEKAIGLFLATLEEAWNLGYRR 790
Cdd:COG3899   990 ALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAAAAAAAAAALAAAAALL 1069

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178278  791 LFQDDALWLLPMWESWREAEPKRAAAWQGLADLLREQCRKLSVDPESFDENQDVSHREREILRLVAAGLSNRDIAQAVHL 870
Cdd:COG3899  1070 AAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAAAALLLLAAALALALAAL 1149


                  ...
gi 489178278  871 SEA 873
Cdd:COG3899  1150 LLL 1152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH