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Conserved domains on  [gi|489176538|ref|WP_003086060|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Pseudomonas]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-133 2.39e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 76.93  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   5 ALYDYLERLTSLMRAWSREQPLVAELQPVQLSALHYLARCNrysdtPLGVTE---YLGLTKGTVSQSLKVLEGRGLISKL 81
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-----GLTQSElaeRLGLTKSTVSRLLDRLEEKGLVERE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489176538  82 PDARDRRSVHLRLTDAGRALIEAVIPP--QFLEQAVTALG-EKGEHLQGLLRDLL 133
Cdd:COG1846   86 PDPEDRRAVLVRLTEKGRALLEEARPAleALLAELLAGLSeEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-133 2.39e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 76.93  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   5 ALYDYLERLTSLMRAWSREQPLVAELQPVQLSALHYLARCNrysdtPLGVTE---YLGLTKGTVSQSLKVLEGRGLISKL 81
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-----GLTQSElaeRLGLTKSTVSRLLDRLEEKGLVERE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489176538  82 PDARDRRSVHLRLTDAGRALIEAVIPP--QFLEQAVTALG-EKGEHLQGLLRDLL 133
Cdd:COG1846   86 PDPEDRRAVLVRLTEKGRALLEEARPAleALLAELLAGLSeEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-109 5.42e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.54  E-value: 5.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538    30 LQPVQLSALHYLARCNRYSDTPLGvtEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSVHLRLTDAGRALIEAVIPPQ 109
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELA--KRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEAR 85
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-89 9.54e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.81  E-value: 9.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   30 LQPVQLSALHYLARcnRYSDTPLGVTEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRS 89
Cdd:pfam12802   3 LTPAQFRVLLALAR--NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 72-141 2.81e-07

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 48.21  E-value: 2.81e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489176538  72 LEGRGLISKLPDARDRRSVHLRLTDAGRALIEAVIPPQF--LEQAVTAL-GEKGEHLQGLLRDLLVVIQRQED 141
Cdd:PRK10870  95 LEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHncLHQLWSALsTTEKDQLEQITRKLLSRLDQMEQ 167
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 56-103 5.79e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 5.79e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489176538  56 EYLGLTKGTVSQSLKVLEGRGLISKlpdARDRRSVHLRLTDAGRALIE 103
Cdd:cd00090   28 ERLGLSQSTVSRHLKKLEEAGLVES---RREGRRVYYSLTDAERLLAL 72
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-133 2.39e-18

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 76.93  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   5 ALYDYLERLTSLMRAWSREQPLVAELQPVQLSALHYLARCNrysdtPLGVTE---YLGLTKGTVSQSLKVLEGRGLISKL 81
Cdd:COG1846   11 RLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAG-----GLTQSElaeRLGLTKSTVSRLLDRLEEKGLVERE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489176538  82 PDARDRRSVHLRLTDAGRALIEAVIPP--QFLEQAVTALG-EKGEHLQGLLRDLL 133
Cdd:COG1846   86 PDPEDRRAVLVRLTEKGRALLEEARPAleALLAELLAGLSeEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-109 5.42e-14

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 64.54  E-value: 5.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538    30 LQPVQLSALHYLARCNRYSDTPLGvtEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSVHLRLTDAGRALIEAVIPPQ 109
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLSVSELA--KRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEAR 85
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-89 9.54e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.81  E-value: 9.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   30 LQPVQLSALHYLARcnRYSDTPLGVTEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRS 89
Cdd:pfam12802   3 LTPAQFRVLLALAR--NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
30-98 1.34e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 46.90  E-value: 1.34e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538   30 LQPVQLSALHYLARcnRYSDTPLG-VTEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSVHLRLTDAG 98
Cdd:pfam13463   1 LTRLEALILHNIGH--RGDPKTLAdICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 72-141 2.81e-07

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 48.21  E-value: 2.81e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489176538  72 LEGRGLISKLPDARDRRSVHLRLTDAGRALIEAVIPPQF--LEQAVTAL-GEKGEHLQGLLRDLLVVIQRQED 141
Cdd:PRK10870  95 LEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHncLHQLWSALsTTEKDQLEQITRKLLSRLDQMEQ 167
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
56-106 3.25e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 41.73  E-value: 3.25e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489176538  56 EYLGLTKGTVSQSLKVLEGRGLISKLPDArdrrsvHLRLTDAGRALIEAVI 106
Cdd:COG1321   32 ERLGVSPPSVTEMLKKLEEKGLVEYEPYG------GITLTEEGRELALRIV 76
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 56-90 1.31e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 38.30  E-value: 1.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 489176538   56 EYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSV 90
Cdd:pfam01047  25 EKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
59-107 5.48e-04

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 37.92  E-value: 5.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489176538  59 GLTKGTVSQSLKVLEGRGLISKLPDARDRRSVHLRLTDAGRALIEAVIP 107
Cdd:COG1733   47 GISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLLPVLDA 95
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 56-103 5.79e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 5.79e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 489176538  56 EYLGLTKGTVSQSLKVLEGRGLISKlpdARDRRSVHLRLTDAGRALIE 103
Cdd:cd00090   28 ERLGLSQSTVSRHLKKLEEAGLVES---RREGRRVYYSLTDAERLLAL 72
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
50-96 9.96e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.94  E-value: 9.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489176538  50 TPLGVTEYLGLTKGTVSQSLKVLEGRGLISKlpdARDRRSVHLRLTD 96
Cdd:COG3398  113 TNKELAEELGISRSTVSWHLKRLEEDGLVER---ERDGRNVRYYLNP 156
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
56-88 1.22e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 37.61  E-value: 1.22e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 489176538  56 EYLGLTKGTVSQSLKVLEGRGLISKLPDARDRR 88
Cdd:COG1510   50 EELGVSKSSVSTALRELEDWGLVRRVRKPGDRK 82
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
30-116 1.60e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 37.18  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538  30 LQPVQLSALHYLARCNRYSD---TPLGVTEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSVHLRLTDAGRALIEAV- 105
Cdd:PRK11512  33 LSPLDITAAQFKVLCSIRCAaciTPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCh 112

                         90
                 ....*....|..
gi 489176538 106 -IPPQFLEQAVT 116
Cdd:PRK11512 113 qLVGQDLHQELT 124
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
56-106 3.29e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 3.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 489176538    56 EYLGLTKGTVSQSLKVLEGRGLISKLpdaRDRRSVHLRLTD-AGRALIEAVI 106
Cdd:smart00418  18 EILGLSQSTVSHHLKKLREAGLVESR---REGKRVYYSLTDeKVADLLEELL 66
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
41-132 5.75e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.01  E-value: 5.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489176538  41 LARCNRYSDTPLGVTEYLGLTKGTVSQSLKVLEGRGLISKLPDARDRRSvHLRLTDAGRALIEAVIPPQFLEQAVTALGE 120
Cdd:COG1777   23 LALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGREDGR-ARKYYRLSAFRLEVTLTPDLFARLARELEA 101

                         90
                 ....*....|..
gi 489176538 121 KGEHLQGLLRDL 132
Cdd:COG1777  102 YRRELSGRLARI 113
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
55-105 8.13e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 34.09  E-value: 8.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489176538  55 TEYLGLTKGTVSQSLKVLEGRGLISklpDARDRRSVHLRLTDAG-RALIEAV 105
Cdd:COG0640   40 AEALGLSQSTVSHHLKVLREAGLVT---SRREGRWVYYRLADEAlAELLEWL 88
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 54-99 8.85e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 8.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489176538  54 VTEYLGLTKGTVSQSLKVLEGRGLISKLpdaRDRRSVHLRLTDAGR 99
Cdd:COG2512   36 IVKETGWSKSKVSRLLSRLEERGLIEKE---RVGRENVVELPEDEP 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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