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Conserved domains on  [gi|489173101|ref|WP_003082649|]
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MULTISPECIES: SMP-30/gluconolactonase/LRE family protein [Pseudomonas]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 11465288)

SMP-30/gluconolactonase/LRE family protein similar to Staphylococcus lactonase drp35 and Zymomonas mobilis gluconolactonase, which hydrolyzes the gluconolactone formed by glucose-fructose oxidoreductase to form gluconate;

CATH:  2.120.10.30
EC:  3.1.1.-
Gene Ontology:  GO:0005515|GO:0046872|GO:0016787
PubMed:  9868369
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-266 2.91e-46

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 158.52  E-value: 2.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  54 LLGQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFVDTGGRPLGMDFDAAGNLILADAWKGLLRIDPQ-GK 130
Cdd:COG3386    1 KLADAGFRLGEGPVWDPDGRLYwVDIPGGRIHRYDpDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 131 VETLATEAdGVPFAFTDDLDIASDGRIYFSDASskfhqpdyildllEARPHGRLLRYDPsTGKTEVLLKDLYFANGVALS 210
Cdd:COG3386   81 VTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMG-------------EYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFS 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489173101 211 ANEDFVLVNETYRYRITRYWLKGE-KAGQHEVFID--NLPGLPDNLQGDRKGTFWVALP 266
Cdd:COG3386  146 PDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-266 2.91e-46

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 158.52  E-value: 2.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  54 LLGQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFVDTGGRPLGMDFDAAGNLILADAWKGLLRIDPQ-GK 130
Cdd:COG3386    1 KLADAGFRLGEGPVWDPDGRLYwVDIPGGRIHRYDpDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 131 VETLATEAdGVPFAFTDDLDIASDGRIYFSDASskfhqpdyildllEARPHGRLLRYDPsTGKTEVLLKDLYFANGVALS 210
Cdd:COG3386   81 VTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMG-------------EYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFS 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489173101 211 ANEDFVLVNETYRYRITRYWLKGE-KAGQHEVFID--NLPGLPDNLQGDRKGTFWVALP 266
Cdd:COG3386  146 PDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 147-234 2.70e-32

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 116.00  E-value: 2.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  147 DDLDIASD-GRIYFSDASSKFHQPDYILDLLEARPHGRLLRYDPSTGKTEVLLKDLYFANGVALSANEDFVLVNETYRYR 225
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 489173101  226 ITRYWLKGE 234
Cdd:pfam03088  81 ISRYWIKEP 89
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 56-264 1.23e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.82  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAglAD---GRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKG-LLR 124
Cdd:cd05819   50 GDGQFNEPAGVAVDSDGNLYV--ADtgnHRIQKFDPDGNFLASFGGSGdgdgefnGPRGIAVDSSGNIYVADTGNHrIQK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 125 IDPQGKVETLATEADGVPFAFTD--DLDIASDGRIYFSDasskfhqpdyildlleaRPHGRLLRYDP------STGKTEV 196
Cdd:cd05819  128 FDPDGEFLTTFGSGGSGPGQFNGptGVAVDSDGNIYVAD-----------------TGNHRIQVFDPdgnfltTFGSTGT 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 197 LLKDLYFANGVALSaNEDFVLVNETYRYRITRYWLKGEKAGQHEVFIDNLPGL--PDNLQGDRKGTFWVA 264
Cdd:cd05819  191 GPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFnrPSGLAVDSDGNLYVA 259
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 63-158 2.29e-05

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 45.73  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  63 PEDTAVDSQGRVYAGL--------ADGRVVRLDASGKVETFVD--TGgrPLGMDFDAAGNLILA-----DAWKG-----L 122
Cdd:NF033206 205 PTGVAVGPDGALYVSEltgfpfppGRARVYRVDPGGAPTVYATgfTG--LTDLAFDPDGNLYVLelaggGLLKGdptgsL 282

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489173101 123 LRIDPQGKVETLateADGVPFAftDDLDIASDGRIY 158
Cdd:NF033206 283 IRIAPDGTRTTL---LDGLELP--TGLAVGPDGTLY 313
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-266 2.91e-46

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 158.52  E-value: 2.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  54 LLGQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFVDTGGRPLGMDFDAAGNLILADAWKGLLRIDPQ-GK 130
Cdd:COG3386    1 KLADAGFRLGEGPVWDPDGRLYwVDIPGGRIHRYDpDGGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDPAdGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 131 VETLATEAdGVPFAFTDDLDIASDGRIYFSDASskfhqpdyildllEARPHGRLLRYDPsTGKTEVLLKDLYFANGVALS 210
Cdd:COG3386   81 VTVLADEY-GKPLNRPNDGVVDPDGRLYFTDMG-------------EYLPTGALYRVDP-DGSLRVLADGLTFPNGIAFS 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489173101 211 ANEDFVLVNETYRYRITRYWLKGE-KAGQHEVFID--NLPGLPDNLQGDRKGTFWVALP 266
Cdd:COG3386  146 PDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 147-234 2.70e-32

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 116.00  E-value: 2.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  147 DDLDIASD-GRIYFSDASSKFHQPDYILDLLEARPHGRLLRYDPSTGKTEVLLKDLYFANGVALSANEDFVLVNETYRYR 225
Cdd:pfam03088   1 NALDVDPEtGVLYFTDSSSRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 489173101  226 ITRYWLKGE 234
Cdd:pfam03088  81 ISRYWIKEP 89
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
58-264 4.65e-17

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 80.06  E-value: 4.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  58 GQLHGPEDTAVDSQGRV-YAGLADGRVVRLD-ASGKVETFVDTGGR--PLGMDFDAAGNLILADAWKG-LLRIDPQ-GKV 131
Cdd:COG4257   56 GGGSGPHGIAVDPDGNLwFTDNGNNRIGRIDpKTGEITTFALPGGGsnPHGIAFDPDGNLWFTDQGGNrIGRLDPAtGEV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 132 ETLATEADGvpfAFTDDLDIASDGRIYFSDASSkfhqpdyildllearphGRLLRYDPSTGKTEV--LLKDLYFANGVAL 209
Cdd:COG4257  136 TEFPLPTGG---AGPYGIAVDPDGNLWVTDFGA-----------------NAIGRIDPDTGTLTEyaLPTPGAGPRGLAV 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489173101 210 SANeDFVLVNETYRYRITRYWLKGEKAGQHEVFIDnlPGLPDNLQGDRKGTFWVA 264
Cdd:COG4257  196 DPD-GNLWVADTGSGRIGRFDPKTGTVTEYPLPGG--GARPYGVAVDGDGRVWFA 247
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 56-264 1.23e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.82  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAglAD---GRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKG-LLR 124
Cdd:cd05819   50 GDGQFNEPAGVAVDSDGNLYV--ADtgnHRIQKFDPDGNFLASFGGSGdgdgefnGPRGIAVDSSGNIYVADTGNHrIQK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 125 IDPQGKVETLATEADGVPFAFTD--DLDIASDGRIYFSDasskfhqpdyildlleaRPHGRLLRYDP------STGKTEV 196
Cdd:cd05819  128 FDPDGEFLTTFGSGGSGPGQFNGptGVAVDSDGNIYVAD-----------------TGNHRIQVFDPdgnfltTFGSTGT 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 197 LLKDLYFANGVALSaNEDFVLVNETYRYRITRYWLKGEKAGQHEVFIDNLPGL--PDNLQGDRKGTFWVA 264
Cdd:cd05819  191 GPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFnrPSGLAVDSDGNLYVA 259
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 41-86 1.65e-15

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 69.82  E-value: 1.65e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489173101   41 GVLEPNDTLMKAELLGQGQLHGPEDTAVDSQGRVYAGLADGRVVRL 86
Cdd:pfam20067   1 GPFAPNDRLAGAELIALGGEHGPEDIAVDPDGRLYTGLHDGRIVRM 46
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-229 9.68e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 73.12  E-value: 9.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  55 LGQGQLHGPEDTAVDSQGRVYagLAD---GRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKG-LL 123
Cdd:cd05819   96 DGDGEFNGPRGIAVDSSGNIY--VADtgnHRIQKFDPDGEFLTTFGSGGsgpgqfnGPTGVAVDSDGNIYVADTGNHrIQ 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 124 RIDPQGKVETLATEADGVPFAFTDDLDIA--SDGRIYFSDASskfhqpdyildllearpHGRLLRYDP------STGKTE 195
Cdd:cd05819  174 VFDPDGNFLTTFGSTGTGPGQFNYPTGIAvdSDGNIYVADSG-----------------NNRVQVFDPdgagfgGNGNFL 236

                        170       180       190
                 ....*....|....*....|....*....|....
gi 489173101 196 VLLKDLYFANGVALSANeDFVLVNETYRYRITRY 229
Cdd:cd05819  237 GSDGQFNRPSGLAVDSD-GNLYVADTGNNRIQVF 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
61-234 4.09e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.59  E-value: 4.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  61 HGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFV--DTGGRPLGMDFDAAGNLILADAWKG-LLRIDPQ-GKVETL 134
Cdd:COG4257  102 SNPHGIAFDPDGNLWfTDQGGNRIGRLDpATGEVTEFPlpTGGAGPYGIAVDPDGNLWVTDFGANaIGRIDPDtGTLTEY 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 135 ATEAdgvPFAFTDDLDIASDGRIYFSDASSkfhqpdyildllearphGRLLRYDPSTGK-TEVLLKDL-YFANGVALSAN 212
Cdd:COG4257  182 ALPT---PGAGPRGLAVDPDGNLWVADTGS-----------------GRIGRFDPKTGTvTEYPLPGGgARPYGVAVDGD 241

                        170       180
                 ....*....|....*....|..
gi 489173101 213 eDFVLVNETYRYRITRYWLKGE 234
Cdd:COG4257  242 -GRVWFAESGANRIVRFDPDTE 262
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 81-266 4.17e-14

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 71.14  E-value: 4.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101   81 GRVVRLDASGKVETFVDTGGrPLGMDFD-AAGNLILADAwKGLLRIDPQ-GKVETLAT-EADGVPFAFTDDLDIASDGRI 157
Cdd:pfam08450  22 GRIHRLDPATGKETVWDTPG-PVGAIAPrDDGGLIVALK-DGVALLDLAtGELTPLADpEDDDWPLNRFNDGKVDPDGRF 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  158 YFSDASsKFHQPDYILdllearphGRLLRYDPStGKTEVLLKDLYFANGVALSANEDFVLVNETYRYRITRY--WLKGEK 235
Cdd:pfam08450 100 WFGTMG-DDEAPGGDP--------GALYRLDPD-GKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYdyDLDGGL 169

                         170       180       190
                  ....*....|....*....|....*....|...
gi 489173101  236 AGQHEVFID--NLPGLPDNLQGDRKGTFWVALP 266
Cdd:pfam08450 170 ISNRRVFADfkPGLGRPDGMAVDAEGNVWVARW 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 56-229 1.05e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 70.43  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKG-LLRID 126
Cdd:cd05819    3 GPGELNNPQGIAVDSSGNIYvADTGNNRIQVFDPDGNFITSFGSFGsgdgqfnEPAGVAVDSDGNLYVADTGNHrIQKFD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 127 PQGKVETLATEADGVPFAFTD--DLDIASDGRIYFSDASskfhqpdyildllearpHGRLLRYDPST------GKTEVLL 198
Cdd:cd05819   83 PDGNFLASFGGSGDGDGEFNGprGIAVDSSGNIYVADTG-----------------NHRIQKFDPDGeflttfGSGGSGP 145

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489173101 199 KDLYFANGVALSANEDfVLVNETYRYRITRY 229
Cdd:cd05819  146 GQFNGPTGVAVDSDGN-IYVADTGNHRIQVF 175
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
62-198 1.24e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 70.05  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  62 GPEDTAVDSQGRVYAGL-ADGRVVRLD-ASGKVETFV--DTGGRPLGMDFDAAGNLILADAWKG-LLRIDPQ-GKVETLA 135
Cdd:COG4257  146 GPYGIAVDPDGNLWVTDfGANAIGRIDpDTGTLTEYAlpTPGAGPRGLAVDPDGNLWVADTGSGrIGRFDPKtGTVTEYP 225

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489173101 136 TEADGV-PFAFTDDldiaSDGRIYFSDASSkfhqpdyildllearphGRLLRYDPSTGKTEVLL 198
Cdd:COG4257  226 LPGGGArPYGVAVD----GDGRVWFAESGA-----------------NRIVRFDPDTELTEYVL 268
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 59-164 4.70e-12

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 66.01  E-value: 4.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  59 QLHGPEDTAVDSQGRVYagLAD---GRVVRLDASGKVETFVDTGG---------------RPLGMDFDAAGNLILADAWK 120
Cdd:cd14953  185 QFNNPTGVAVDAAGNLY--VADrgnHRIRKITPDGVVTTVAGTGTagfsgdggataaqlnNPTGVAVDAAGNLYVADSGN 262

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489173101 121 GLLR-IDPQGKVETLATEADGVP----------FAFTDDLDIASDGRIYFSDASS 164
Cdd:cd14953  263 HRIRkITPAGVVTTVAGGGAGFSgdggpatsaqFNNPTGVAVDAAGNLYVADTGN 317
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 57-226 1.18e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 61.78  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  57 QGQLHGPEDTAVDSQGRVYagLADG---RVVRLDASGKVETFVDTGG---------------RPLGMDFDAAGNLILADA 118
Cdd:cd14953  128 AAQFNYPTGVAVDAAGNLY--VADTgnhRIRKITPDGVVTTVAGTGGagyagdgpataaqfnNPTGVAVDAAGNLYVADR 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 119 WKGLLR-IDPQGKVETLA------TEADGVP----FAFTDDLDIASDGRIYFSDASSkfH-----QPDYILDLLEARPHG 182
Cdd:cd14953  206 GNHRIRkITPDGVVTTVAgtgtagFSGDGGAtaaqLNNPTGVAVDAAGNLYVADSGN--HrirkiTPAGVVTTVAGGGAG 283

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 489173101 183 RLLRYDPSTGKTevllkdLYFANGVALSANeDFVLVNETYRYRI 226
Cdd:cd14953  284 FSGDGGPATSAQ------FNNPTGVAVDAA-GNLYVADTGNNRI 320
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
87-351 2.29e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.34  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  87 DASGKVETFV--DTGGRPLGMDFDAAGNLILADAWKG-LLRIDPQ-GKVetlaTEADGVPFAFTDDLDIASDGRIYFSDA 162
Cdd:COG4257    2 ASAVDITEYPvpAPGSGPRDVAVDPDGAVWFTDQGGGrIGRLDPAtGEF----TEYPLGGGSGPHGIAVDPDGNLWFTDN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 163 SSkfhqpdyildllearphGRLLRYDPSTGK-TEVLLKDLYFA-NGVALSANEDfVLVNETYRYRITRYwlkGEKAGQHE 240
Cdd:COG4257   78 GN-----------------NRIGRIDPKTGEiTTFALPGGGSNpHGIAFDPDGN-LWFTDQGGNRIGRL---DPATGEVT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 241 VFidNLPGLPDNLQG---DRKGTFWVALPTPRK-----ADADFLHRHPwlkaqlaklprmfLPKPTAYGLVIAIDEQGRI 312
Cdd:COG4257  137 EF--PLPTGGAGPYGiavDPDGNLWVTDFGANAigridPDTGTLTEYA-------------LPTPGAGPRGLAVDPDGNL 201

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489173101 313 VrsLHDTSGHHLRMI--------------TSAKPVG------DQLYFGSLENDRIGRLA 351
Cdd:COG4257  202 W--VADTGSGRIGRFdpktgtvteyplpgGGARPYGvavdgdGRVWFAESGANRIVRFD 258
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 59-161 1.94e-08

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 55.23  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  59 QLHGPEDTAVDSQGRVYagLADG---RVVRLDASGKVETFVDTGGR--------------PLGMDFDAAGNLILADAWKG 121
Cdd:cd14953   21 RFNSPSGVAVDAAGNLY--VADRgnhRIRKITPDGVVTTVAGTGTAgfadgggaaaqfntPSGVAVDAAGNLYVADTGNH 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489173101 122 LLR-IDPQGKVETLAteADGVPFaFTDD-----------LDIA--SDGRIYFSD 161
Cdd:cd14953   99 RIRkITPDGVVSTLA--GTGTAG-FSDDggataaqfnypTGVAvdAAGNLYVAD 149
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 55-161 2.18e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 54.58  E-value: 2.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  55 LGQGQLHGPEDTAVDSQGRVYAglADG---RVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKGLLR 124
Cdd:cd14957  106 SGDGQFNGPYGIAVDSNGNIYV--ADTgnhRIQVFTSSGTFSYSIGSGGtgpgqfnGPQGIAVDSDGNIYVADTGNHRIQ 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489173101 125 I-DPQGK-VETLATEADGvPFAFTDDLDIA--SDGRIYFSD 161
Cdd:cd14957  184 VfTSSGTfQYTFGSSGSG-PGQFSDPYGIAvdSDGNIYVAD 223
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 56-264 1.90e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.90  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAglAD---GRVVRLDASGKVETFV-------DTGGRPLGMDFDAAGNLILADAWKG-LLR 124
Cdd:cd14956    8 GPGQFKDPRGIAVDADDNVYV--ADarnGRIQVFDKDGTFLRRFgttgdgpGQFGRPRGLAVDKDGWLYVADYWGDrIQV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 125 IDPQGKVETLATEADGVP--FAFTDDLDIASDGRIYFSDASS------------------------KFHQPD-------- 170
Cdd:cd14956   86 FTLTGELQTIGGSSGSGPgqFNAPRGVAVDADGNLYVADFGNqriqkfdpdgsflrqwggtgiepgSFNYPRgvavdpdg 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 171 --YILDLLEAR-----PHGRLLRydpSTGKTEVLLKDLYFANGVALSANEDfVLVNETYRYRITRYWLKGEKAGQHEVFi 243
Cdd:cd14956  166 tlYVADTYNDRiqvfdNDGAFLR---KWGGRGTGPGQFNYPYGIAIDPDGN-VFVADFGNNRIQKFTADGTFLTSWGSP- 240

                        250       260
                 ....*....|....*....|....
gi 489173101 244 DNLPGLPDNLQG---DRKGTFWVA 264
Cdd:cd14956  241 GTGPGQFKNPWGvvvDADGTVYVA 264
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
67-268 9.30e-07

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 50.76  E-value: 9.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  67 AVDSQGRVY----AGLADGRVVRLDASGKVETFVDTGGRPLG----MDFDAAGNLILADAWKGLLRIDPQGKVETLATEA 138
Cdd:COG3292  273 AEDSDGNLWirlwIGTYGGGLFRLDPKTGKFKRYNPNGLPSNsvysILEDSDGNLWIGTSGGGLYRYDPKTGKFTKFSED 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 139 DGVPFAFTDDLDIASDGRIYFS---------DASSKFHQ-----------PDYILDLLEARpHGR---------LLRYDP 189
Cdd:COG3292  353 NGLSNNFIRSILEDSDGNLWVGtngglyrldPKTGKFTNfthdpdknglsSNYINSIFEDS-DGRlwigtdgggLYRYDP 431

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 190 STGKTEVLLKDLYFANGVALSANED-------FVLVNETYRYRITRYWLKGEKAGQHEVFIDNLPGLPDNLQGDRKGTFW 262
Cdd:COG3292  432 KTGKFKHFTTKDGLPSNTIYSILEDdngnlwnFNSASNLGLLSLLGGLLGGLNLGNAIKLPLSNLGLLLTLLLLGINLSL 511


                 ....*.
gi 489173101 263 VALPTP 268
Cdd:COG3292  512 VRSLIS 517
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 56-166 9.67e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 49.50  E-value: 9.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAglAD---GRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKGllRI 125
Cdd:cd14955   58 GDGQFYSPTGIAVDSDGNVYV--ADtgnHRIQKFDSTGTFLTKWGSSGsgdgqfnSPSGIAVDSAGNVYVTDSGNN--RI 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489173101 126 ---DPQGK-VETLATEADGV-PFAFTDDLDIASDGRIYFSDASS----KF 166
Cdd:cd14955  134 qkfDSSGTfITKWGSFGSGDgQFNSPTGIAVDSAGNVYVADTGNnriqKF 183
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 56-229 1.74e-06

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 48.80  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYagLADG----RVVRLDASGKvetFVDTGGRPL----------GMDFDAAGNLILADAWKG 121
Cdd:cd14958  123 DQTHFCKPTDVAVAPDGDIF--VADGycnsRIVKFSPDGK---LLKSWGEPGsgpgqfnlphSIALDEDGRVYVADRENG 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 122 llRI---DPQGKVETLATEAD-GVPFAftddLDIASDGRIYFSDasskfhQPDYILDLLEARphGRLLRY-----DPSTG 192
Cdd:cd14958  198 --RIqvfDADGKFLTEWTNPElGRPYA----LAIDPDGLLYVVD------GPPRLNRSLPVR--GFVIRIgkgliLGRFG 263

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 489173101 193 KTEVLLKDLYFANGVALSANEDfVLVNETYRYRITRY 229
Cdd:cd14958  264 PGGKAPGQFQNPHDIAVDSGGD-IYVGELGPNRVQKF 299
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
53-132 1.78e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.86  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  53 ELLGQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFV--DTGGRPLGMDFDAAGNLILADaWKG--LLRID 126
Cdd:COG4257  180 EYALPTPGAGPRGLAVDPDGNLWvADTGSGRIGRFDpKTGTVTEYPlpGGGARPYGVAVDGDGRVWFAE-SGAnrIVRFD 258


                 ....*.
gi 489173101 127 PQGKVE 132
Cdd:COG4257  259 PDTELT 264
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 58-161 8.05e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.89  E-value: 8.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  58 GQLHGPEDTAVDSQGRVYagLADG---RVVRLDASGkveTFVDTGGR----------PLGMDFDAAGNLILADAWKGllR 124
Cdd:cd14956  151 GSFNYPRGVAVDPDGTLY--VADTyndRIQVFDNDG---AFLRKWGGrgtgpgqfnyPYGIAIDPDGNVFVADFGNN--R 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489173101 125 I---DPQGKVET-LATEADGV-PFAFTDDLDIASDGRIYFSD 161
Cdd:cd14956  224 IqkfTADGTFLTsWGSPGTGPgQFKNPWGVVVDADGTVYVAD 265
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
60-222 8.14e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  60 LHGPEDTAVDSQGRVY-AGLADGRVVRLD-ASGKVETFVDTGGRPLGMDFDAAGNLIL-ADAWKG-LLRIDPQGK--VET 133
Cdd:COG3391   68 ADADGADAGADGRRLYvANSGSGRVSVIDlATGKVVATIPVGGGPRGLAVDPDGGRLYvADSGNGrVSVIDTATGkvVAT 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 134 LATEADGVPFAFTDDldiasDGRIYFSDASSkfhqpDYILDLlearphgrLLRYDPSTGKTEVLLKDLYFANGVALSANE 213
Cdd:COG3391  148 IPVGAGPHGIAVDPD-----GKRLYVANSGS-----NTVSVI--------VSVIDTATGKVVATIPVGGGPVGVAVSPDG 209


                 ....*....
gi 489173101 214 DFVLVNETY 222
Cdd:COG3391  210 RRLYVANRG 218
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 63-233 8.85e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.81  E-value: 8.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  63 PEDTAVDSQGRVYagLAD---GRVVRLD-ASGKVETFVDTGG----RPLGMDFDAAGNLILADAWKG-LLRIDPQGKVET 133
Cdd:cd14962   14 PYGVAADGRGRIY--VADtgrGAVFVFDlPNGKVFVIGNAGPnrfvSPIGVAIDANGNLYVSDAELGkVFVFDRDGKFLR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 134 lateADGVPFAFTDDLDIASD---GRIYFSDASSkfHQPdYILDllearPHGRLLRYDPSTGKTEvllKDLYFANGVALS 210
Cdd:cd14962   92 ----AIGAGALFKRPTGIAVDpagKRLYVVDTLA--HKV-KVFD-----LDGRLLFDIGKRGSGP---GEFNLPTDLAVD 156

                        170       180
                 ....*....|....*....|...
gi 489173101 211 ANEDfVLVNETYRYRITRYWLKG 233
Cdd:cd14962  157 RDGN-LYVTDTMNFRVQIFDADG 178
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
62-164 1.30e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  62 GPEDTAVDSQG-RVY-AGLADGRVVRLD-ASGKVETFVDTGGRPLGMDFDAAGN-LILADAWKG-----LLRIDPQ-GKV 131
Cdd:COG3391  111 GPRGLAVDPDGgRLYvADSGNGRVSVIDtATGKVVATIPVGAGPHGIAVDPDGKrLYVANSGSNtvsviVSVIDTAtGKV 190

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489173101 132 -ETLATEADGVPFAFTDDldiasDGRIYFSDASS 164
Cdd:COG3391  191 vATIPVGGGPVGVAVSPD-----GRRLYVANRGS 219
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 56-161 1.68e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.75  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYagLAD---GRVVRLDASGKvetFVDT--GGR--------PLGMDFDAAGNLILADAWKGL 122
Cdd:cd14963  143 EPGELSYPNGIAVDEDGNIY--VADsgnGRIQVFDKNGK---FIKElnGSPdgksgfvnPRGIAVDPDGNLYVVDNLSHR 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489173101 123 LRI-DPQGKV-ETLAT-EADGVPFAFTDDLDIASDGRIYFSD 161
Cdd:cd14963  218 VYVfDEQGKElFTFGGrGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 56-163 1.95e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 45.72  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLDASGKVETFVDTGG-------RPLGMDFDAAGNLILADAWKGLLRI-D 126
Cdd:cd14957   13 GNGQFNTPRGIAVDSAGNIYvADTGNNRIQVFTSSGVYSYSIGSGGtgsgqfnSPYGIAVDSNGNIYVADTDNNRIQVfN 92

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489173101 127 PQGKVE-TLATEADG-VPFAFTDDLDIASDGRIYFSDAS 163
Cdd:cd14957   93 SSGVYQySIGTGGSGdGQFNGPYGIAVDSNGNIYVADTG 131
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 63-158 2.29e-05

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 45.73  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  63 PEDTAVDSQGRVYAGL--------ADGRVVRLDASGKVETFVD--TGgrPLGMDFDAAGNLILA-----DAWKG-----L 122
Cdd:NF033206 205 PTGVAVGPDGALYVSEltgfpfppGRARVYRVDPGGAPTVYATgfTG--LTDLAFDPDGNLYVLelaggGLLKGdptgsL 282

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489173101 123 LRIDPQGKVETLateADGVPFAftDDLDIASDGRIY 158
Cdd:NF033206 283 IRIAPDGTRTTL---LDGLELP--TGLAVGPDGTLY 313
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 56-119 3.71e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.87  E-value: 3.71e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489173101  56 GQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLDASGkveTFVDTGG----------RPLGMDFDAAGNLILADAW 119
Cdd:cd14955   11 GDGQFNSPSGIAVDSAGNVYvADTGNNRIQKFDSTG---TFLTKWGssgsgdgqfySPTGIAVDSDGNVYVADTG 82
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 56-163 5.00e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 44.50  E-value: 5.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYagLAD---GRVVRLDASGKVETFVDTGG---RPLGMDFDAAGNLIL-ADAWKGLLRI-DP 127
Cdd:cd14962   52 GPNRFVSPIGVAIDANGNLY--VSDaelGKVFVFDRDGKFLRAIGAGAlfkRPTGIAVDPAGKRLYvVDTLAHKVKVfDL 129

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489173101 128 QGKVETLATEADGVP--FAFTDDLDIASDGRIYFSDAS 163
Cdd:cd14962  130 DGRLLFDIGKRGSGPgeFNLPTDLAVDRDGNLYVTDTM 167
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 56-162 9.31e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.43  E-value: 9.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLDASGK-VETFVDTG-----GRPLGMDFDaAGNLILADAWKGLLRI-DP 127
Cdd:cd14963   51 GPGEFKYPYGIAVDSDGNIYvADLYNGRIQVFDPDGKfLKYFPEKKdrvklISPAGLAID-DGKLYVSDVKKHKVIVfDL 129

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489173101 128 QGK-VETLATEADGV-PFAFTDDLDIASDGRIYFSDA 162
Cdd:cd14963  130 EGKlLLEFGKPGSEPgELSYPNGIAVDEDGNIYVADS 166
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 56-161 1.21e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.96  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYagLADG---RVVRLDASGKvetFVDTGG----------RPLGMDFDAAGNLILADAWKGL 122
Cdd:cd14962  143 GPGEFNLPTDLAVDRDGNLY--VTDTmnfRVQIFDADGK---FLRSFGergdgpgsfaRPKGIAVDSEGNIYVVDAAFDN 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489173101 123 LRI-DPQGKVETLATEADGVP--FAFTDDLDIASDGRIYFSD 161
Cdd:cd14962  218 VQIfNPEGELLLTVGGPGSGPgeFYLPSGIAIDKDDRIYVVD 259
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 60-133 1.41e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.96  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  60 LHGPEDTAVDSQGRVYAG-----LADGRVVRLDASGKVET---------------------FVDTGGRPL---------- 103
Cdd:COG3386   92 LNRPNDGVVDPDGRLYFTdmgeyLPTGALYRVDPDGSLRVladgltfpngiafspdgrtlyVADTGAGRIyrfdldadgt 171

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489173101 104 ------------------GMDFDAAGNLILADAWKG-LLRIDPQGKVET 133
Cdd:COG3386  172 lgnrrvfadlpdgpggpdGLAVDADGNLWVALWGGGgVVRFDPDGELLG 220
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 60-226 1.02e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.27  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  60 LHGPEDTAVDSQGRVY-AGLADGRVVRLDA-SGKVETFVDTG-GRPLGMDFDAAGNLILADAwkgllridPQGKVETLAT 136
Cdd:cd14952    9 LDGPGGVAVDAAGNVYvADSGNNRVLKLAAgSTTQTVLPFTGlYQPQGVAVDAAGTVYVTDF--------GNNRVLKLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 137 EADG---VPFAFTDD---LDIASDGRIYFSDasskfhqpdyildlleaRPHGRLLRYDP-STGKTEVLLKDLYFANGVAL 209
Cdd:cd14952   81 GSTTqtvLPFTGLNDptgVAVDAAGNVYVAD-----------------TGNNRVLKLAAgSNTQTVLPFTGLSNPDGVAV 143

                        170
                 ....*....|....*..
gi 489173101 210 SANEDfVLVNETYRYRI 226
Cdd:cd14952  144 DGAGN-VYVTDTGNNRV 159
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
67-264 1.59e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 40.36  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  67 AVDSQGRVYAGLADGrVVRLD-ASGKVETFVDTGG-----RPLGMD------FDAAGNLILADAWKGLLRIDPQ-GKVET 133
Cdd:COG3292  130 AEDSDGNIWVGTSNG-LYRYDpKTGKFKRFTLDGLpsntiTSLAEDadgnlwVDSDGNLWIGTDGNGLYRLDPNtGKFEH 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 134 LATEADgvPFAFTDD--LDIASD------------GRIYFSDASSKFHQ----------PDYILDLLEARP--------- 180
Cdd:COG3292  209 ITHDPD--PNSLSSNsiYSLFEDregnlwvgtyggGLNYLDPNNSKFKSyrhndpnglsGNSVRSIAEDSDgnlwirlwi 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 181 ---HGRLLRYDPSTGKTEVLLKDLYFANGV-ALSANEDFVLVNETYRYRITRYWLKGEKAgqheVFIDNLPGLPDN---- 252
Cdd:COG3292  287 gtyGGGLFRLDPKTGKFKRYNPNGLPSNSVySILEDSDGNLWIGTSGGGLYRYDPKTGKF----TKFSEDNGLSNNfirs 362

                        250
                 ....*....|..
gi 489173101 253 LQGDRKGTFWVA 264
Cdd:COG3292  363 ILEDSDGNLWVG 374
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 56-164 1.62e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 39.56  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVY-AGLADGRVVRLDASGkveTFVDTGGR----------PLGMDFDAAGNLILADAWKGllR 124
Cdd:cd14957  154 GPGQFNGPQGIAVDSDGNIYvADTGNHRIQVFTSSG---TFQYTFGSsgsgpgqfsdPYGIAVDSDGNIYVADTGNH--R 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489173101 125 I---DPQGKVE----TLATEADGvpFAFTDDLDIASDGRIYFSDASS 164
Cdd:cd14957  229 IqvfTSSGAYQysigTSGSGNGQ--FNYPYGIAVDNDGKIYVADSNN 273
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
67-265 2.23e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 39.97  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  67 AVDSQGRVYAGLADGrVVRLD-ASGKVETFVDTGGRPLG----MDFDAAGNLILADAwKGLLRIDPQ-GKVETLATeaDG 140
Cdd:COG3292   87 LEDSDGRLWIGTDGG-LSRYDpKTDKFTRYPLDPGLPNNsirsIAEDSDGNIWVGTS-NGLYRYDPKtGKFKRFTL--DG 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101 141 VPFAFTDDLDIASDGRIYFsDASSKFhqpdyildLLEARPHGrLLRYDPSTGKTEVLLKDLyfaNGVALSAN------ED 214
Cdd:COG3292  163 LPSNTITSLAEDADGNLWV-DSDGNL--------WIGTDGNG-LYRLDPNTGKFEHITHDP---DPNSLSSNsiyslfED 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489173101 215 fvlvNE------TYR---YRITRYWLKGEKagqheVFIDNLPGLPDN----LQGDRKGTFWVAL 265
Cdd:COG3292  230 ----REgnlwvgTYGgglNYLDPNNSKFKS-----YRHNDPNGLSGNsvrsIAEDSDGNLWIRL 284
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 60-117 2.33e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.11  E-value: 2.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489173101  60 LHGPEDTAVDSQGRVY-AGLADGRVVRLDASGKVETFVDTGGR--PLGMDFDAAGNLILAD 117
Cdd:cd14952  177 LNSPSGVAVDTAGNVYvTDHGNNRVLKLAAGSTTPTVLPFTGLngPLGVAVDAAGNVYVAD 237
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
75-127 4.20e-03

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 38.76  E-value: 4.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  75 YAGLADGRVVR--LDASGKVET----FVDTGGRPLGMDFDAAGNLILADAWKG-LLRIDP 127
Cdd:COG2133  306 VADLGSRRVVRvpLDGDGKVVGeedfLTGAGGRPRDVAQGPDGALYVLDDNDGrIYRITY 365
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 56-125 6.76e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 37.94  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAglADG---RVVRLDASGkveTFVDTGG----------RPLGMDFDAAGNLILADAWKGl 122
Cdd:cd14955  199 GDGQFNAPYGIAVDSAGNVYV--ADTgnnRIQKFDSSG---TFITKWGsegsgdgqfnSPSGIAVDSAGNVYVADSGNN- 272


                 ...
gi 489173101 123 lRI 125
Cdd:cd14955  273 -RI 274
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 56-162 9.53e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 37.26  E-value: 9.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489173101  56 GQGQLHGPEDTAVDSQGRVYAgLADG--RVVRLDASGKVETFV-------DTGGRPLGMDFDAAGNLILADAWKGLLRI- 125
Cdd:cd14961    6 WPGTLNNPTGVAVTPTGRVVV-ADDGnkRIQVFDSDGNCLQQFgpkgdagQDIRYPLDVAVTPDGHIVVTDAGDRSVKVf 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489173101 126 DPQGKVETLATEADGVPFaftdDLDIASDGRIYFSDA 162
Cdd:cd14961   85 SFDGRLKLFVRKSFSLPW----GVAVNPSGEILVTDS 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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