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Conserved domains on  [gi|489127455|ref|WP_003037247|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Citrobacter]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.72e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127455 11 AEQAAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLI 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 489127455 91 ATLKTLY 97
Cdd:COG0640  86 EWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.72e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127455 11 AEQAAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLI 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 489127455 91 ATLKTLY 97
Cdd:COG0640  86 EWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 6.35e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 81.35  E-value: 6.35e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489127455 14 AAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-84 4.61e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 4.61e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489127455 18 LKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNA 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 1.86e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.86e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489127455   29 ILCMLCGSPGTsAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLIATL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 2.71e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.60  E-value: 2.71e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489127455  23 NPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-86 5.09e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 5.09e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489127455 18 LKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIkNAAV 86
Cdd:NF033789  2 FKALSDPTRREILELLKEGD-MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL-NTTV 68
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 1.77e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 41.19  E-value: 1.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489127455   25 KRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIES 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-97 3.72e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 87.25  E-value: 3.72e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127455 11 AEQAAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLI 90
Cdd:COG0640   7 LEELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELL 85


                ....*..
gi 489127455 91 ATLKTLY 97
Cdd:COG0640  86 EWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 6.35e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 81.35  E-value: 6.35e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489127455 14 AAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-84 4.61e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 4.61e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489127455 18 LKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNA 84
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 1.86e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 1.86e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489127455   29 ILCMLCGSPGTsAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKNAAVNSLIATL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-83 3.27e-14

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 63.74  E-value: 3.27e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489127455  12 EQAAALLKAMSNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIKN 83
Cdd:COG3398   85 EEEKKILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
9-87 3.34e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 60.05  E-value: 3.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127455   9 ASAEQAAALLKAMSNPKRLLILCMLCGSPGTsAGELARVTGLSPSATSQHLARMREEGLIESQRD-----AQRILYSIKN 83
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPAY-VSELARELGVSRQAVYKHLRKLEEAGLVESYREgredgRARKYYRLSA 80


                 ....
gi 489127455  84 AAVN 87
Cdd:COG1777   81 FRLE 84
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 2.71e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.60  E-value: 2.71e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489127455  23 NPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
12-80 6.71e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 53.81  E-value: 6.71e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489127455 12 EQAAALLKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIES-----QRDAQRILYS 80
Cdd:COG4189   7 EESLEVLKALASETRLRILRLLAEEP-LNVNELAEALGLPKSTVSYHIRKLEEAGLIRTeykpgKRGRQKICYL 79
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-73 4.00e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.30  E-value: 4.00e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489127455  15 AALLKAMSNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRD 73
Cdd:pfam12840  1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-86 5.09e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 48.56  E-value: 5.09e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489127455 18 LKAMSNPKRLLILCMLCGSPgTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIkNAAV 86
Cdd:NF033789  2 FKALSDPTRREILELLKEGD-MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL-NTTV 68
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-75 4.32e-08

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 47.66  E-value: 4.32e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489127455  23 NPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQ 75
Cdd:COG1846   37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-74 6.60e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 45.27  E-value: 6.60e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489127455  23 NPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDA 74
Cdd:pfam12802  4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSP 55
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-79 1.77e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.02  E-value: 1.77e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489127455  19 KAMSNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQRILY 79
Cdd:COG3398   16 NVLDNDTRRRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRY 76
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
25-68 3.04e-07

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 43.19  E-value: 3.04e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489127455  25 KRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLI 68
Cdd:pfam13412  2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-79 2.38e-06

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.20  E-value: 2.38e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 489127455    23 NPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDA--QRILY 79
Cdd:smart00347   9 TPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPedRRSVL 67
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
20-89 6.44e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.60  E-value: 6.44e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489127455  20 AMSNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRDAQ-----RILYSIKNAAVNSL 89
Cdd:COG2345    9 ALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRgrgrpAKLYRLTEAGRARF 83
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 43-82 9.60e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 40.28  E-value: 9.60e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 489127455 43 ELARVTGLSPSATSQHLARMREEGLIESQRDAQRILYSIK 82
Cdd:COG2512  35 EIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELP 74
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 1.77e-05

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 41.19  E-value: 1.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489127455   25 KRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIES 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
29-69 6.48e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 38.99  E-value: 6.48e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 489127455  29 ILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIE 69
Cdd:COG1522   10 ILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
43-78 9.89e-05

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 36.65  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 489127455   43 ELARVTGLSPSATSQHLARMREEGLIESQRDAQRIL 78
Cdd:smart00419 13 EIAELLGLTRETVSRTLKRLEKEGLISREGGRIVIL 48
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-73 1.06e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.76  E-value: 1.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489127455  23 NPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRD 73
Cdd:pfam01047  2 TLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 18-70 5.72e-04

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 36.97  E-value: 5.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489127455  18 LKAMSNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIES 70
Cdd:cd09655  133 LLAGLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLVEQ 185
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 27-72 6.15e-04

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 36.38  E-value: 6.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489127455   27 LLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQR 72
Cdd:pfam02082  12 LLYLALHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVR 57
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 27-69 8.94e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 35.57  E-value: 8.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 489127455    27 LLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIE 69
Cdd:smart00344   6 RKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 43-71 1.12e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.56  E-value: 1.12e-03
                        10        20
                ....*....|....*....|....*....
gi 489127455 43 ELARVTGLSPSATSQHLARMREEGLIESQ 71
Cdd:cd00092  30 EIADYLGLTRETVSRTLKELEEEGLISRR 58
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
10-81 3.56e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 34.80  E-value: 3.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489127455  10 SAEQAAALLKAMSNpkrllilcmlcGSPGTSAGELARVTGLSPSATSQHLARMREEGLIEsqRDAQRILYSI 81
Cdd:COG1414    7 SLERALAILEALAE-----------AGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE--RDPEGGRYRL 65
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 1-78 4.09e-03

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 34.58  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489127455   1 MTELEQLQASAEQAAALLKAMSNPKRLL-ILCMLCGSPGT------SAGELARVTGLSPSATSQHLARMREEGLIESQRD 73
Cdd:COG0664  114 LRLLARRLRQLQERLVSLAFLSAEERLArFLLELADRLDGridlplTQEEIASYLGLTRETVSRILKKLEKEGLIELERG 193


                 ....*
gi 489127455  74 AQRIL 78
Cdd:COG0664  194 RITIL 198
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
9-73 4.40e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 33.72  E-value: 4.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489127455   9 ASAEQAAALLkamsNPKRLLILCMLCGSPGTSAGELARVTGLSPSATSQHLARMREEGLIESQRD 73
Cdd:COG4190   41 ESPESLARVL----TPKRLELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLVELEED 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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