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Conserved domains on  [gi|489123298|ref|WP_003033104|]
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MULTISPECIES: PTS lactose/cellobiose transporter subunit IIA [Citrobacter]

Protein Classification

PTS lactose/cellobiose transporter subunit IIA( domain architecture ID 10003680)

PTS lactose/cellobiose transporter subunit IIA helps catalyze the phosphorylation of incoming sugar substrates leading to their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 5-101 5.05e-39

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 441056  Cd Length: 100  Bit Score: 125.63  E-value: 5.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   5 ETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMNA 84
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*..
gi 489123298  85 MVIQDLAGDMIELYRRL 101
Cdd:COG1447   81 MTEKDLAKELIELYKKL 97
 
Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 5-101 5.05e-39

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 125.63  E-value: 5.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   5 ETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMNA 84
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*..
gi 489123298  85 MVIQDLAGDMIELYRRL 101
Cdd:COG1447   81 MTEKDLAKELIELYKKL 97
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 6-99 5.23e-36

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 117.53  E-value: 5.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298    6 TIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMNAM 85
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|....
gi 489123298   86 VIQDLAGDMIELYR 99
Cdd:pfam02255  81 TEKDLAKELIELYK 94
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
2-101 4.36e-30

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 103.43  E-value: 4.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   2 EELETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHL 81
Cdd:PRK10454  15 EELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHAQDHL 94

                         90       100
                 ....*....|....*....|
gi 489123298  82 MNAMVIQDLAGDMIELYRRL 101
Cdd:PRK10454  95 MTSMLARELITELIELHEKL 114
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 4-100 5.95e-29

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 99.97  E-value: 5.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   4 LETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMN 83
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*..
gi 489123298  84 AMVIQDLAGDMIELYRR 100
Cdd:cd00215   81 TITLKDLAKEMIELYKK 97
 
Name Accession Description Interval E-value
CelC COG1447
Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and ...
 5-101 5.05e-39

Phosphotransferase system cellobiose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 441056  Cd Length: 100  Bit Score: 125.63  E-value: 5.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   5 ETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMNA 84
Cdd:COG1447    1 EEIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKVQTELIQKEAGGEKVEVSLLLVHAQDHLMTA 80

                         90
                 ....*....|....*..
gi 489123298  85 MVIQDLAGDMIELYRRL 101
Cdd:COG1447   81 MTEKDLAKELIELYKKL 97
PTS_IIA pfam02255
PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar ...
 6-99 5.23e-36

PTS system, Lactose/Cellobiose specific IIA subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 460510  Cd Length: 94  Bit Score: 117.53  E-value: 5.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298    6 TIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMNAM 85
Cdd:pfam02255   1 EIAMEIILHAGNARSLAMEALKAAKEGDFEEAEELLKEADEELLEAHKAQTELIQKEAGGEKVEVSLLLVHAQDHLMTAM 80

                          90
                  ....*....|....
gi 489123298   86 VIQDLAGDMIELYR 99
Cdd:pfam02255  81 TEKDLAKELIELYK 94
PRK10454 PRK10454
PTS N,N'-diacetylchitobiose transporter subunit IIA;
2-101 4.36e-30

PTS N,N'-diacetylchitobiose transporter subunit IIA;


Pssm-ID: 182472  Cd Length: 115  Bit Score: 103.43  E-value: 4.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   2 EELETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHL 81
Cdd:PRK10454  15 EELEEVVMGLIINSGQARSLAYAALKQAKQGDFAAAKAMMDQSRMALNEAHLVQTKLIEGDQGEGKMKVSLVLVHAQDHL 94

                         90       100
                 ....*....|....*....|
gi 489123298  82 MNAMVIQDLAGDMIELYRRL 101
Cdd:PRK10454  95 MTSMLARELITELIELHEKL 114
PTS_IIA_lac cd00215
PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial ...
 4-100 5.95e-29

PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.


Pssm-ID: 238133  Cd Length: 97  Bit Score: 99.97  E-value: 5.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   4 LETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHLMN 83
Cdd:cd00215    1 LELISFQIILHAGNARSKALEALKAAKEGDFAEAEELLEEANDSLNEAHHAQTKLLQQEASGEKVEVSLLLVHAQDHLMT 80

                         90
                 ....*....|....*..
gi 489123298  84 AMVIQDLAGDMIELYRR 100
Cdd:cd00215   81 TITLKDLAKEMIELYKK 97
celC PRK09591
PTS cellobiose transporter subunit IIA;
2-101 1.98e-15

PTS cellobiose transporter subunit IIA;


Pssm-ID: 181975  Cd Length: 104  Bit Score: 65.98  E-value: 1.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123298   2 EELETIIMELLVNAGAARSQALTALQLARKGDFSGAEQAMTESREYVKQAHKIQTQLIGIDEGTGKLPVNLITVHSQDHL 81
Cdd:PRK09591   4 EELQVAAFEIILHSGNARTEVHEAFAAMREGNFDLAEQKLNQSNEELLEAHHAQTKLLQEYASGTEIKIEIIMVHAQDHL 83

                         90       100
                 ....*....|....*....|
gi 489123298  82 MNAMVIQDLAGDMIELYRRL 101
Cdd:PRK09591  84 MTTMTLREVAKEMLALYKKV 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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