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Conserved domains on  [gi|489123296|ref|WP_003033102|]
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MULTISPECIES: PTS sugar transporter subunit IIB [Citrobacter]

Protein Classification

PTS sugar transporter subunit IIB( domain architecture ID 10003678)

subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS)

CATH:  3.40.50.2300
EC:  2.7.1.-
Gene Ontology:  GO:0008643|GO:0009401|GO:0008982
PubMed:  8246840|2197982|11361063

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 2-101 4.45e-46

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


:

Pssm-ID: 441049  Cd Length: 100  Bit Score: 143.36  E-value: 4.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:COG1440    1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDDYDVVLLGPQVRYMLDEIKKIADEKGIPVAVIDM 80

                         90       100
                 ....*....|....*....|
gi 489123296  82 MDYGMMKGDAVLDKALKLLE 101
Cdd:COG1440   81 QDYGMMDGEKVLDQALELLK 100
 
Name Accession Description Interval E-value
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 2-101 4.45e-46

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 143.36  E-value: 4.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:COG1440    1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDDYDVVLLGPQVRYMLDEIKKIADEKGIPVAVIDM 80

                         90       100
                 ....*....|....*....|
gi 489123296  82 MDYGMMKGDAVLDKALKLLE 101
Cdd:COG1440   81 QDYGMMDGEKVLDQALELLK 100
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 3-98 7.93e-45

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 139.95  E-value: 7.93e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   3 NIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDMM 82
Cdd:cd05564    1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYIDDADVVLLGPQVRYMLDEVKKKAAEYGIPVAVIDMM 80

                         90
                 ....*....|....*.
gi 489123296  83 DYGMMKGDAVLDKALK 98
Cdd:cd05564   81 DYGMMNGEKVLKQALK 96
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 2-93 9.65e-26

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 91.69  E-value: 9.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296    2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:TIGR00853   4 TNILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDDADVVLLAPQVAYMLPDLKKETDKKGIPVEVING 83

                          90
                  ....*....|..
gi 489123296   82 MDYGMMKGDAVL 93
Cdd:TIGR00853  84 AQYGKLTGAGVL 95
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 3-95 1.73e-16

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 68.13  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296    3 NIVLCCAAGMSTSMLV-QRMKDAAQKKG-VDVTIKAVP-VAEFEENIATADIVLLGPQVKYEQAKLQAiadplGKKVAVI 79
Cdd:pfam02302   1 KILTACGAGMATSLMAaEALEKAAKELGiVEAQGAAGVnELTAEDIADDADVVILAPDVAVEDLARFA-----GKPVYVI 75

                          90
                  ....*....|....*..
gi 489123296   80 DMMD-YGMMKGDAVLDK 95
Cdd:pfam02302  76 PVKDaLGMKDAEEVLEK 92
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
2-97 1.93e-16

PTS sugar transporter subunit IIB;


Pssm-ID: 182499  Cd Length: 106  Bit Score: 68.40  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADplGKKVAVIDM 81
Cdd:PRK10499   4 KHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLP--NKPVEVIDS 81

                         90
                 ....*....|....*.
gi 489123296  82 MDYGMMKGDAVLDKAL 97
Cdd:PRK10499  82 LLYGKVDGLGVLKAAV 97
 
Name Accession Description Interval E-value
CelA COG1440
Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and ...
 2-101 4.45e-46

Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism];


Pssm-ID: 441049  Cd Length: 100  Bit Score: 143.36  E-value: 4.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:COG1440    1 KKILLVCAAGMSTSLLVKKMKKAAKERGIDVEIEAVSAGELEDVIDDYDVVLLGPQVRYMLDEIKKIADEKGIPVAVIDM 80

                         90       100
                 ....*....|....*....|
gi 489123296  82 MDYGMMKGDAVLDKALKLLE 101
Cdd:COG1440   81 QDYGMMDGEKVLDQALELLK 100
PTS_IIB_chitobiose_lichenan cd05564
PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N, ...
 3-98 7.93e-45

PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99906  Cd Length: 96  Bit Score: 139.95  E-value: 7.93e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   3 NIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDMM 82
Cdd:cd05564    1 KILLVCSAGMSTSILVKKMKKAAEKRGIDAEIEAVPESELEEYIDDADVVLLGPQVRYMLDEVKKKAAEYGIPVAVIDMM 80

                         90
                 ....*....|....*.
gi 489123296  83 DYGMMKGDAVLDKALK 98
Cdd:cd05564   81 DYGMMNGEKVLKQALK 96
pts-lac TIGR00853
PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and ...
 2-93 9.65e-26

PTS system, lactose/cellobiose family IIB component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as those in E. coli. While the Lac family usually consists of two polypeptide components IIA and IICB, the Chb permease of E. coli consists of three IIA, IIB and IIC. This family is specific for the IIB subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273300  Cd Length: 95  Bit Score: 91.69  E-value: 9.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296    2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:TIGR00853   4 TNILLLCAAGMSTSLLVNKMNKAAEEYGVPVKIAAGSYGAAGEKLDDADVVLLAPQVAYMLPDLKKETDKKGIPVEVING 83

                          90
                  ....*....|..
gi 489123296   82 MDYGMMKGDAVL 93
Cdd:TIGR00853  84 AQYGKLTGAGVL 95
PTS_IIB pfam02302
PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar ...
 3-95 1.73e-16

PTS system, Lactose/Cellobiose specific IIB subunit; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This family also contains the fructose specific IIB subunit.


Pssm-ID: 396744  Cd Length: 92  Bit Score: 68.13  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296    3 NIVLCCAAGMSTSMLV-QRMKDAAQKKG-VDVTIKAVP-VAEFEENIATADIVLLGPQVKYEQAKLQAiadplGKKVAVI 79
Cdd:pfam02302   1 KILTACGAGMATSLMAaEALEKAAKELGiVEAQGAAGVnELTAEDIADDADVVILAPDVAVEDLARFA-----GKPVYVI 75

                          90
                  ....*....|....*..
gi 489123296   80 DMMD-YGMMKGDAVLDK 95
Cdd:pfam02302  76 PVKDaLGMKDAEEVLEK 92
PRK10499 PRK10499
PTS sugar transporter subunit IIB;
2-97 1.93e-16

PTS sugar transporter subunit IIB;


Pssm-ID: 182499  Cd Length: 106  Bit Score: 68.40  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADplGKKVAVIDM 81
Cdd:PRK10499   4 KHIYLFCSAGMSTSLLVSKMRAQAEKYEVPVIIEAFPETLAGEKGQNADVVLLGPQIAYMLPEIQRLLP--NKPVEVIDS 81

                         90
                 ....*....|....*.
gi 489123296  82 MDYGMMKGDAVLDKAL 97
Cdd:PRK10499  82 LLYGKVDGLGVLKAAV 97
PTS_IIB cd00133
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ...
 3-96 1.79e-12

PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.


Pssm-ID: 99904  Cd Length: 84  Bit Score: 57.65  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   3 NIVLCCAAGMSTS-MLVQRMKDAAQKKGVDVTIKAVPVAEFeENIATADIVLLGPQVKyeqaklqaiADPLGKKVAVIDM 81
Cdd:cd00133    1 KILVVCGSGIGSSsMLAEKLEKAAKELGIEVKVEAQGLSEV-IDLADADLIISTVPLA---------ARFLGKPVIVVSP 70

                         90
                 ....*....|....*
gi 489123296  82 MDyGMMKGDAVLDKA 96
Cdd:cd00133   71 LL-NEKDGEKILEKL 84
celB PRK09590
PTS cellobiose transporter subunit IIB;
1-79 1.39e-11

PTS cellobiose transporter subunit IIB;


Pssm-ID: 181974  Cd Length: 104  Bit Score: 55.94  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   1 MKNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATA--DIVLLGPQVKYEQAKLQAIADPLGKKVAV 78
Cdd:PRK09590   1 MKKALIICAAGMSSSMMAKKTTEYLKEQGKDIEVDAITATEGEKAIAAAeyDLYLVSPQTKMYFKQFEEAGAKVGKPVVQ 80


                 .
gi 489123296  79 I 79
Cdd:PRK09590  81 I 81
PTS_IIB_galactitol cd05566
PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific ...
 2-52 1.28e-06

PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99908  Cd Length: 89  Bit Score: 42.52  E-value: 1.28e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489123296   2 KNIVLCCAAGMSTSMLVQ-RMKDAAQKKGVDVTIKAVPVAEFEENIATADIV 52
Cdd:cd05566    1 KKILVACGTGVATSTVVAsKVKELLKENGIDVKVEQCKIAEVPSLLDDADLI 52
PTS_IIB_lactose cd05565
PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate: ...
 2-101 2.80e-06

PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIC and IIB domains are expressed as a single protein from the lac operon. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include lactose, chitobiose/lichenan, ascorbate, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99907  Cd Length: 99  Bit Score: 42.00  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   2 KNIVLCCAAGMSTSMLVQRMKDAAQKKGVDVTIKAVPVAEFEENIATADIVLLGPQVKYEQAKLQAIADPLGKKVAVIDM 81
Cdd:cd05565    1 LNVLVLCAGGGTSGLLANALNKGAKERGVPLEAAAGAYGSHYDMIPDYDLVILAPQMASYYDELKKDTDRLGIKLVTTTG 80

                         90       100
                 ....*....|....*....|
gi 489123296  82 MDYGMMKGDAvlDKALKLLE 101
Cdd:cd05565   81 KQYIELTRDP--DGALKFVL 98
PTS_IIB_ascorbate cd05563
PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific ...
 3-83 5.16e-03

PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a transmembrane channel IIC subunit. Subunits IIA, IIB, and IIC are encoded by the sgaA, sgaB, and sgaT genes of the E. coli sgaTBA operon. In some bacteria, the IIB (SgaB) domain is fused C-terminal to the IIA (SgaT) domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include ascorbate, chitobiose/lichenan, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.


Pssm-ID: 99905  Cd Length: 86  Bit Score: 33.27  E-value: 5.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489123296   3 NIVLCCAAGMSTSMLVQR-MKDAAQKKGVDVTIKAVPVAEFEENiaTADIVLLGPQVkyeqakLQAIADPLGKKVAVIDM 81
Cdd:cd05563    1 KILAVCGSGLGSSLMLKMnVEKVLKELGIEAEVEHTDLGSAKAS--SADIIVTSKDL------ASLLADGGAKVIGLKNI 72


                 ..
gi 489123296  82 MD 83
Cdd:cd05563   73 MD 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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