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Conserved domains on  [gi|489115889|ref|WP_003025738|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Citrobacter]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1000955)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 46-367 3.16e-112

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15048:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 553  Bit Score: 338.13  E-value: 3.16e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  46 MSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDASS 125
Cdd:PRK15048 194 LAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSD 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 126 QIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDIS 205
Cdd:PRK15048 274 AIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIA 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 206 GSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELA 285
Cdd:PRK15048 354 DSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLV 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 286 QQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAVF 365
Cdd:PRK15048 434 ESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAF 513


                 ..
gi 489115889 366 KL 367
Cdd:PRK15048 514 RL 515
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 46-367 3.16e-112

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 338.13  E-value: 3.16e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  46 MSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDASS 125
Cdd:PRK15048 194 LAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSD 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 126 QIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDIS 205
Cdd:PRK15048 274 AIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIA 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 206 GSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELA 285
Cdd:PRK15048 354 DSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLV 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 286 QQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAVF 365
Cdd:PRK15048 434 ESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAF 513


                 ..
gi 489115889 366 KL 367
Cdd:PRK15048 514 RL 515
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
45-367 2.13e-77

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 247.63  E-value: 2.13e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  45 IMSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDAS 124
Cdd:COG0840  183 LLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 125 SQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVI------ 198
Cdd:COG0840  263 EQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVegieei 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 199 --------EKMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTL 270
Cdd:COG0840  343 resveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEEL 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 271 ISDSHT--------------HVGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQ 336
Cdd:COG0840  423 IEEIQSeteeaveameegseEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQE 502

                        330       340       350
                 ....*....|....*....|....*....|.
gi 489115889 337 NAALVQQSSAATRSLEEQSSALIEAMAVFKL 367
Cdd:COG0840  503 NAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 120-366 3.80e-60

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 194.81  E-value: 3.80e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   120 VRDASSQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIE 199
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   200 KMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTH-- 277
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEEtn 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   278 ------------VGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSS 345
Cdd:smart00283 162 eavaameessseVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 489115889   346 AATRSLEEQSSALIEAMAVFK 366
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 146-345 5.65e-52

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 171.65  E-value: 5.65e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 146 ESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDISGSSSRIADILSVIDGIAFQT 225
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 226 NILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELAQQAGETMDEIANEVMRMTKL 305
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489115889 306 MREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSS 345
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 179-331 5.72e-46

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 154.90  E-value: 5.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  179 LAKSVSDTADRGSEMVCYVIEKMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLAS 258
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  259 RSAEAAKEIRTLI--------------SDSHTHVGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVN 324
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162


                  ....*..
gi 489115889  325 IAVIQMD 331
Cdd:pfam00015 163 QAVARMD 169
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 46-367 3.16e-112

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 338.13  E-value: 3.16e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  46 MSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDASS 125
Cdd:PRK15048 194 LAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSD 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 126 QIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDIS 205
Cdd:PRK15048 274 AIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIA 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 206 GSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELA 285
Cdd:PRK15048 354 DSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLV 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 286 QQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAVF 365
Cdd:PRK15048 434 ESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAF 513


                 ..
gi 489115889 366 KL 367
Cdd:PRK15048 514 RL 515
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
45-368 9.52e-112

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 336.93  E-value: 9.52e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  45 IMSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDAS 124
Cdd:PRK15041 195 ILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGA 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 125 SQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDI 204
Cdd:PRK15041 275 NAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDI 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 205 SGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSEL 284
Cdd:PRK15041 355 STSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTL 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 285 AQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAV 364
Cdd:PRK15041 435 VESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAV 514


                 ....
gi 489115889 365 FKLQ 368
Cdd:PRK15041 515 FRIQ 518
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
45-368 4.32e-92

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 285.81  E-value: 4.32e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  45 IMSAAMLTAIALlaviwFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDAS 124
Cdd:PRK09793 196 IIVAAIYISSAL-----WWTRKMIVQPLAIIGSHFDSIAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGS 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 125 SQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDI 204
Cdd:PRK09793 271 QEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEI 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 205 SGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSEL 284
Cdd:PRK09793 351 ATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKL 430

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 285 AQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAV 364
Cdd:PRK09793 431 VNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAV 510


                 ....
gi 489115889 365 FKLQ 368
Cdd:PRK09793 511 FTLE 514
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
45-367 2.13e-77

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 247.63  E-value: 2.13e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  45 IMSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDAS 124
Cdd:COG0840  183 LLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 125 SQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVI------ 198
Cdd:COG0840  263 EQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVegieei 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 199 --------EKMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTL 270
Cdd:COG0840  343 resveetaETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAEATKEIEEL 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 271 ISDSHT--------------HVGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQ 336
Cdd:COG0840  423 IEEIQSeteeaveameegseEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQE 502

                        330       340       350
                 ....*....|....*....|....*....|.
gi 489115889 337 NAALVQQSSAATRSLEEQSSALIEAMAVFKL 367
Cdd:COG0840  503 NAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 120-366 3.80e-60

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 194.81  E-value: 3.80e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   120 VRDASSQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIE 199
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   200 KMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTH-- 277
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEEtn 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889   278 ------------VGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSS 345
Cdd:smart00283 162 eavaameessseVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 489115889   346 AATRSLEEQSSALIEAMAVFK 366
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 146-345 5.65e-52

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 171.65  E-value: 5.65e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 146 ESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDISGSSSRIADILSVIDGIAFQT 225
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 226 NILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELAQQAGETMDEIANEVMRMTKL 305
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489115889 306 MREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSS 345
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 179-331 5.72e-46

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 154.90  E-value: 5.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  179 LAKSVSDTADRGSEMVCYVIEKMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLAS 258
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  259 RSAEAAKEIRTLI--------------SDSHTHVGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVN 324
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162


                  ....*..
gi 489115889  325 IAVIQMD 331
Cdd:pfam00015 163 QAVARMD 169
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 45-137 1.14e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 43.80  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  45 IMSAAMLTAIALLAVIW--FMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRD 122
Cdd:COG5000    8 LLLLLLIALLLLLLALWlaLLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEE 87

                         90
                 ....*....|....*
gi 489115889 123 ASSQIDIGSRELTAG 137
Cdd:COG5000   88 RRRYLETILENLPAG 102
HAMP pfam00672
HAMP domain;
63-113 3.02e-04

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 38.37  E-value: 3.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489115889   63 MLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHAL 113
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
51-370 1.79e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 40.48  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  51 LTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQRVRDASSQIDIG 130
Cdd:COG2770  219 LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAE 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 131 SRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGSEMVCYVIEKMRDISGSSSR 210
Cdd:COG2770  299 LARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLA 378

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 211 IADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLISDSHTHVGEGSELAQQAGE 290
Cdd:COG2770  379 LEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLA 458

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 291 TMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSLEEQSSALIEAMAVFKLQTA 370
Cdd:COG2770  459 ELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEA 538
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
69-118 1.88e-03

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 36.07  E-value: 1.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 489115889    69 LKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRHALGDSVQ 118
Cdd:smart00304   4 LRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 32-370 4.14e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 39.10  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889  32 ASTRVITSLIYHGIMSAAMLTAIALLAVIWFMLRNKFLKPLDNMVEQLERLATGDLSPVTTLSASAEFNRLNAAMDDMRH 111
Cdd:COG3850  106 LLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMAD 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 112 ALGDSVQRVRDASSQIDIGSRELTAGNQHLAQRTESTATSLEQTAASMEELTATVKQNAQNAEQAHQLAKSVSDTADRGS 191
Cdd:COG3850  186 ELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLEL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 192 EMVCYVIEKMRDISGSSSRIADILSVIDGIAFQTNILALNASVEAARAGEQGRGFAVVAGEVRNLASRSAEAAKEIRTLI 271
Cdd:COG3850  266 LLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELAS 345

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115889 272 SDSHTHVGEGSELAQQAGETMDEIANEVMRMTKLMREIASASQEQSRGIEQVNIAVIQMDETAQQNAALVQQSSAATRSL 351
Cdd:COG3850  346 ILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIA 425

                        330
                 ....*....|....*....
gi 489115889 352 EEQSSALIEAMAVFKLQTA 370
Cdd:COG3850  426 GGEAIARGEALAARGLAAA 444
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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