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Conserved domains on  [gi|489115757|ref|WP_003025606|]
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MULTISPECIES: adenylosuccinate synthase [Citrobacter]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 2-432 0e+00

adenylosuccinate synthetase; Provisional


:

Pssm-ID: 234904  Cd Length: 430  Bit Score: 870.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   2 GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALM 81
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEK 161
Cdd:PRK01117  81 KEIDELEARGVDVRERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 162 LKEVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 242 SNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQ 321
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 322 INSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIK 401
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYEL-DGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIK 399

                        410       420       430
                 ....*....|....*....|....*....|.
gi 489115757 402 RIEELTGVPIDIISTGPDRTETMILRDPFDA 432
Cdd:PRK01117 400 RIEELTGVPISIISTGPDRDQTIILRDPFAA 430
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 2-432 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 870.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   2 GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALM 81
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEK 161
Cdd:PRK01117  81 KEIDELEARGVDVRERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 162 LKEVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 242 SNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQ 321
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 322 INSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIK 401
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYEL-DGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIK 399

                        410       420       430
                 ....*....|....*....|....*....|.
gi 489115757 402 RIEELTGVPIDIISTGPDRTETMILRDPFDA 432
Cdd:PRK01117 400 RIEELTGVPISIISTGPDRDQTIILRDPFAA 430
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 4-427 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 810.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   4 NVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKE 83
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  84 MKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLK 163
Cdd:COG0104   81 IDGLEARGVDVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 164 EVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQIN 323
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 324 SLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRI 403
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYEL-DGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERI 399

                        410       420
                 ....*....|....*....|....
gi 489115757 404 EELTGVPIDIISTGPDRTETMILR 427
Cdd:COG0104  400 EELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
6-424 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 759.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEMK 85
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   86 GLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKEV 165
Cdd:pfam00709  81 ELEERGIDVPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  166 MEYHNFQLVNFYKvEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTT 245
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  246 AGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQINSL 325
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  326 SGFCLTKLDVLDGLKEVKICVAYRmPDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRIEE 405
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYE-LDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEE 398

                         410
                  ....*....|....*....
gi 489115757  406 LTGVPIDIISTGPDRTETM 424
Cdd:pfam00709 399 LLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 4-425 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 744.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757     4 NVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKE 83
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    84 MKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARgekaIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLK 163
Cdd:smart00788  81 IEELEAKGVDVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   164 EVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQIN 323
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   324 SLSGFCLTKLDVLDGLKEVKICVAYRmPDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRI 403
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYK-LDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERI 395

                          410       420
                   ....*....|....*....|..
gi 489115757   404 EELTGVPIDIISTGPDRTETMI 425
Cdd:smart00788 396 EELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-431 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 719.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEMK 85
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   86 GLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKEV 165
Cdd:TIGR00184  81 YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  166 MEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTT 245
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  246 AGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQINSL 325
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  326 SGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRIEE 405
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRM-KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEE 399

                         410       420
                  ....*....|....*....|....*.
gi 489115757  406 LTGVPIDIISTGPDRTETMILRDPFD 431
Cdd:TIGR00184 400 LTGVPVTIISTGPEREQTIDLRKELL 425
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-425 1.75e-179

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 503.18  E-value: 1.75e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   3 NNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMK 82
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  83 EMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDlfdkatfaekl 162
Cdd:cd03108   81 EIEELEKKGIDVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 163 kevmeyhnfqlvnfykveavdyqkvlddvmaiadiltSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSS 242
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 243 NTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQI 322
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 323 NSLSGFCLTKLDVldglkevkicvayrmpdgrevtttplaaddwkgiepiyetmpgwsestfgvkersglpqAALNYIKR 402
Cdd:cd03108  273 NGLTELALTKLDV-----------------------------------------------------------NAQKYIER 293

                        410       420
                 ....*....|....*....|...
gi 489115757 403 IEELTGVPIDIISTGPDRTETMI 425
Cdd:cd03108  294 IEELLGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
6-323 2.11e-33

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 127.10  E-value: 2.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQ-GGHNAGHTlVIN--GEKTVLHLIPSGILRENVI-SIIGNGVVLSPSALM 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHT-YIDdeGRKFVHRMLPNGIVSPPLKqVLIGPGSEIDLEVLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSE-ACPLILDYHValdnaREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAE 160
Cdd:NF038379  82 EEIEELEDAGHDVGKRLLIHEqATVIELHKHV-----EEEAGPMTKIGSTKKGIGAARAAKIRRNPSTLGDAEGDFGEGA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 161 KLKEVMEYHnfqlvnfykVEAVDYQkvlddvmaiadiltsmvvdvsdLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVT 240
Cdd:NF038379 157 VRDQPWEIA---------ERVVDNA----------------------LYDFALQAAERIQIEGTQGYSLGLHAGFYPYCT 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 241 SSNTTAGGVATGSGLGPRYVDY--VLGIIKAYSTRVGA-----GPFPTEL-FDDVGeflckQGNEYGATTGRRRRTGWLD 312
Cdd:NF038379 206 SRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGwsgnsYPDQGETtWEELG-----LPEELTTVTKKVRRVGTFS 280

                        330
                 ....*....|.
gi 489115757 313 SVAVRRAVQIN 323
Cdd:NF038379 281 AEQVREAVQAN 291
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 2-432 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 870.13  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   2 GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALM 81
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEK 161
Cdd:PRK01117  81 KEIDELEARGVDVRERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 162 LKEVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 242 SNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQ 321
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 322 INSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIK 401
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYEL-DGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIK 399

                        410       420       430
                 ....*....|....*....|....*....|.
gi 489115757 402 RIEELTGVPIDIISTGPDRTETMILRDPFDA 432
Cdd:PRK01117 400 RIEELTGVPISIISTGPDRDQTIILRDPFAA 430
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 4-427 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 810.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   4 NVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKE 83
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  84 MKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLK 163
Cdd:COG0104   81 IDGLEARGVDVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 164 EVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQIN 323
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 324 SLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRI 403
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYEL-DGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERI 399

                        410       420
                 ....*....|....*....|....
gi 489115757 404 EELTGVPIDIISTGPDRTETMILR 427
Cdd:COG0104  400 EELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
6-424 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 759.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEMK 85
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   86 GLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKEV 165
Cdd:pfam00709  81 ELEERGIDVPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  166 MEYHNFQLVNFYKvEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTT 245
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  246 AGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQINSL 325
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  326 SGFCLTKLDVLDGLKEVKICVAYRmPDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRIEE 405
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYE-LDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEE 398

                         410
                  ....*....|....*....
gi 489115757  406 LTGVPIDIISTGPDRTETM 424
Cdd:pfam00709 399 LLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 4-425 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 744.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757     4 NVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKE 83
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    84 MKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARgekaIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLK 163
Cdd:smart00788  81 IEELEAKGVDVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   164 EVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQIN 323
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   324 SLSGFCLTKLDVLDGLKEVKICVAYRmPDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRI 403
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYK-LDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERI 395

                          410       420
                   ....*....|....*....|..
gi 489115757   404 EELTGVPIDIISTGPDRTETMI 425
Cdd:smart00788 396 EELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 6-431 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 719.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757    6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEMK 85
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   86 GLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKEV 165
Cdd:TIGR00184  81 YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  166 MEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTT 245
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  246 AGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQINSL 325
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  326 SGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRIEE 405
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRM-KGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEE 399

                         410       420
                  ....*....|....*....|....*.
gi 489115757  406 LTGVPIDIISTGPDRTETMILRDPFD 431
Cdd:TIGR00184 400 LTGVPVTIISTGPEREQTIDLRKELL 425
PLN02513 PLN02513
adenylosuccinate synthase
 1-427 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 556.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   1 MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVIN-GEKTVLHLIPSGILRENVISIIGNGVVLSPSA 79
Cdd:PLN02513   1 LSQVSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDeGKKFALHLVPSGILNEKTTCVIGNGVVVHLPG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  80 LMKEMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFA 159
Cdd:PLN02513  81 LFEEIDGLESNGVSCEGRLLVSDRAHLLFDFHQEVDGLREAELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 160 EKLKEVMEYHNFQLVNFyKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYV 239
Cdd:PLN02513 161 EKLRELLADAAARFEGF-EYDASMVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 240 TSSNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRA 319
Cdd:PLN02513 240 TSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYS 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 320 VQINSLSGFCLTKLDVLDGLKEVKICVAYRMPDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNY 399
Cdd:PLN02513 320 CQINGFTSLNLTKLDVLSGLPEIKIGVAYKTPDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAY 399

                        410       420
                 ....*....|....*....|....*...
gi 489115757 400 IKRIEELTGVPIDIISTGPDRTETMILR 427
Cdd:PLN02513 400 VERIEELVGVPVHYIGVGPGRDALIVKP 427
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 2-428 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 518.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   2 GNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALM 81
Cdd:PTZ00350  12 SKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGE--KAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFA 159
Cdd:PTZ00350  92 EEIEQLTKKGINLLGRLYISDRAHLVFDLHQAIDGIQESEKGKggTQIGTTKRGIGPCYSTKASRTGLRVGDLLNFETFE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 160 EKLKEVMEYHNFQlvnfYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYV 239
Cdd:PTZ00350 172 KKYRKLVEKLQEQ----YNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYPYV 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 240 TSSNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRA 319
Cdd:PTZ00350 248 TSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYV 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 320 VQINSLSGFCLTKLDVLDGLKEVKICVAYRMP-DGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALN 398
Cdd:PTZ00350 328 QMINGFDSINLTKLDVLSGLKEIKICVNYKNKgTGLEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQK 407

                        410       420       430
                 ....*....|....*....|....*....|
gi 489115757 399 YIKRIEELTGVPIDIISTGPDRtETMILRD 428
Cdd:PTZ00350 408 YVLFIEELLGVPIVWIGVGPNR-ENMIVKK 436
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 3-425 1.75e-179

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 503.18  E-value: 1.75e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   3 NNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMK 82
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  83 EMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDlfdkatfaekl 162
Cdd:cd03108   81 EIEELEKKGIDVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 163 kevmeyhnfqlvnfykveavdyqkvlddvmaiadiltSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSS 242
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 243 NTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQI 322
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 323 NSLSGFCLTKLDVldglkevkicvayrmpdgrevtttplaaddwkgiepiyetmpgwsestfgvkersglpqAALNYIKR 402
Cdd:cd03108  273 NGLTELALTKLDV-----------------------------------------------------------NAQKYIER 293

                        410       420
                 ....*....|....*....|...
gi 489115757 403 IEELTGVPIDIISTGPDRTETMI 425
Cdd:cd03108  294 IEELLGVPITYISVGPDREQTII 316
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 6-426 1.33e-144

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 418.59  E-value: 1.33e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEMK 85
Cdd:PRK13787   5 LVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEECD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  86 GLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARG-EKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKaTFAEKLKE 164
Cdd:PRK13787  85 RLQKEGFPVKDKLLLSDACHLLFPYHSQIDSARETTSSqEHKIGTTKKGIGICYADKMMRTGLRVGDLLDK-SYKRRLKH 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 165 VMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSNT 244
Cdd:PRK13787 164 LVDEKNRELDKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVTSSNP 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 245 TAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQINS 324
Cdd:PRK13787 244 TTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSVRING 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 325 LSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPlaADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRIE 404
Cdd:PRK13787 324 ITSIALTKIDILSDYDTIPVAVGYKL-NGKTLDCFP--SQGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYISALE 400

                        410       420
                 ....*....|....*....|..
gi 489115757 405 ELTGVPIDIISTGPDRTETMIL 426
Cdd:PRK13787 401 KWIGVKINLVSTGPDRKDTIIG 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 5-423 4.84e-135

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 393.79  E-value: 4.84e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   5 VVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKEM 84
Cdd:PRK13788   4 IAIIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEER 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  85 KGLEDRGIPvrERLLLSEACPLILDYHVALDNarekarGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKE 164
Cdd:PRK13788  84 ENLRAGGLN--PKLLISERAHLVLPHHKYVDG------RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRERVER 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 165 VMEY--HNFQLVNFYKVEavdyqKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSS 242
Cdd:PRK13788 156 LLEAkpNSTREAGWDTVE-----KALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTSS 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 243 NTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQG----NEYGATTGRRRRTGWLDSVAVRR 318
Cdd:PRK13788 231 HPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKY 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 319 AVQINSLSGFCLTKLDVLDGLKEVKICVAYRmPDGRevtttplaaddwkgiePIYETMPGWSESTfGVKERSGLPQAALN 398
Cdd:PRK13788 311 ACEVNGFDGLVLTKLDVLSGLEKVKVCVEYD-DDGQ----------------PVYKELPGWGDLD-GVKSREALPKEAQA 372

                        410       420
                 ....*....|....*....|....*
gi 489115757 399 YIKRIEELTGVPIDIISTGPDRTET 423
Cdd:PRK13788 373 YLELIEETTGVPVVMFSTSPRREDT 397
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 3-425 1.04e-134

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 392.93  E-value: 1.04e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   3 NNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMK 82
Cdd:PRK13783   1 MKRVIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  83 EMKGLEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGeKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKL 162
Cdd:PRK13783  81 ELEELKEKFPDYSGRIFISELAHVVLPVHKELDEIIESVRK-NAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 163 KEVMEYHNfqlvNFYKVEaVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGdfVMFEGAQGTLLDIDHGTYPYVTSS 242
Cdd:PRK13783 160 EKILSLYK----KLYGIE-FDVEKMMEDLLTFYEKIKDLVVSPVEIKRILEEKS--VLFEGTQGVLLDLDVGTYPYVTSS 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 243 NTTAGGVATGSGLgPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQI 322
Cdd:PRK13783 233 NCSTTGVSAGMGF-PVKVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 323 NSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVtTTPLAADDWKGIEPIYETMPGWsESTFGVKersglpqaALNYIKR 402
Cdd:PRK13783 312 SGVDSLVMTKADVLNGFEKIKVCVRYEI-GGKEV-RDPSSLRDLEKAEPVYEEFDGW-KSLEDKN--------FLKFVDF 380

                        410       420
                 ....*....|....*....|...
gi 489115757 403 IEELTGVPIDIISTGPdRTETMI 425
Cdd:PRK13783 381 IERETGRKIAYISTGP-KIEEIV 402
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 6-423 2.20e-133

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 390.32  E-value: 2.20e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVIsIIGNGVVLSPSALMKEMK 85
Cdd:PRK13786   4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  86 GLEDRGIPVR-ERLLLSEACPLILDYHVALDNAREKARGEKaIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKLKE 164
Cdd:PRK13786  83 MLEKHGVKVDaEKLGIDAKTSIIMPYHIELDGLRESARTEK-IGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 165 VMEYHNFQLVNFY-KVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:PRK13786 162 LAPQKEKEIKELGgDPSIVRDEALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQIN 323
Cdd:PRK13786 242 TIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLN 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 324 SLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMPGWSESTFGVKERSGLPQAALNYIKRI 403
Cdd:PRK13786 322 GYTEIALTKLDVLTGLDPIKICVGYEL-DGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERL 400

                        410       420
                 ....*....|....*....|
gi 489115757 404 EELTGVPIDIISTGPDRTET 423
Cdd:PRK13786 401 EELMGVPIKYISVGPGREQT 420
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 3-430 4.62e-126

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 371.66  E-value: 4.62e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   3 NNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMK 82
Cdd:PRK13784   2 SNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  83 EMKGLEDRGIPVR-ERLLLSEACPLILDYHVALDNAREKARGEKaIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEK 161
Cdd:PRK13784  82 EITRLQAKGIAISaENLFVSESCTIITSYHKLLDAVRESNTSEK-IGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 162 LKEVMEYHNFQLVNFYKVEAVDYQKVLDDVMAIADILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTS 241
Cdd:PRK13784 161 LAISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 242 SNTTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEFLCKQGNEYGATTGRRRRTGWLDSVAVRRAVQ 321
Cdd:PRK13784 241 SNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 322 INSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKgIEPIYETMPGWSESTFGVKErsGLPQAALNYIK 401
Cdd:PRK13784 321 CSNLTSIALTKVDVLSDMDTLKVCIGYKY-EGKEIYCAYPGIDLYK-VEPILVEMEPFSIDETVTKD--NMPAALKTYLK 396

                        410       420
                 ....*....|....*....|....*....
gi 489115757 402 RIEELTGVPIDIISTGPDRTETMILRDPF 430
Cdd:PRK13784 397 TIENHVGIPISSLAYGPSREQILFFEDYF 425
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 5-430 3.88e-124

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 367.55  E-value: 3.88e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   5 VVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENvISIIGNGVVLSPSALMKEM 84
Cdd:PRK13785   3 VTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  85 KGLEDRGIPVRERLllSEACPLILDYHVALDNAREKARGEK--AIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAEKL 162
Cdd:PRK13785  82 DALRERGLDPDVRV--AERAHVILPYHRVLDGIEEEAKSDSdlEVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRDRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 163 KEVMEYHNFQLVNFYKV------EAVDYQKVLDDVMAIADILTS--MVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHG 234
Cdd:PRK13785 160 EYVVPQKRALAEDVYGLdasetpEAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDGDNVMLEGAQGTSIDIDHG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 235 TYPYVTSSNTTAGGVATGSGLGPRYV--DYVLGIIKAYSTRVGAGPFPTELFDDVG---------------EFLCKQGNE 297
Cdd:PRK13785 240 NYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTELGGVEGdtpdeggrpdeeelaTYIREEGGE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 298 YGATTGRRRRTGWLDSVAVRRAVQINSLSGFCLTKLDVLDGLKEVKICVAYRMpDGREVTTTPLAADDWKGIEPIYETMP 377
Cdd:PRK13785 320 YGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYEL-DGEELLTMPATTERWARCEPNFRSFD 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489115757 378 GWSESTFGVKERSG---LPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPF 430
Cdd:PRK13785 399 GWPEVDWAAVAEEGydaLPENARTYLEYVSDELDTPIYAVGVGPGREETVVLENPF 454
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 6-427 1.03e-88

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 272.52  E-value: 1.03e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   6 VVLGTQWGDEGKGKIVDLL--TERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVISIIGNGVVLSPSALMKE 83
Cdd:PRK04293   5 IVVGGFFGDEGKGKIIAYLalKDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLLKE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  84 MKGLEdrgipVRERLLLSEACPLILDYHVALDnaREKARGEKAIGTTGRGIGPAYEDKVARRGlrvgdlfdkatfaeKLk 163
Cdd:PRK04293  85 VEELN-----VGGRVFVDYRCGIIEEKHVEED--RSDEHLSKKIGSTGTGCGPANADRVLRRL--------------KL- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 164 evmeyhnfqlvnfykveAVDYqkvlddvmaiaDILTSMVVDVSDLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVTSSN 243
Cdd:PRK04293 143 -----------------AKDV-----------EELEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYVTSKD 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 244 TTAGGVATGSGLGPRYVDYVLGIIKAYSTRVGAGPFPTELFDDVGEflcKQG-NEYGATTGRRRRTGWLDSVAVRRAVQI 322
Cdd:PRK04293 195 TTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAE---KLGlVEYGTVTGRRRRVGPFDFELARRAARI 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 323 NSLSGFCLTKLDVLDglkevkicvayrmpdgrevtttplaaddwkgiepiyetmpgwsESTFGVKERSGLPQAALNYIKR 402
Cdd:PRK04293 272 NGATQIAITKLDKLD-------------------------------------------KEAYGVTEYDKLPPEAKKFIEE 308

                        410       420
                 ....*....|....*....|....*
gi 489115757 403 IEELTGVPIDIISTGPDRTETMILR 427
Cdd:PRK04293 309 IEEELGVPVTLISTGPELEDTIDLR 333
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
6-323 2.11e-33

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 127.10  E-value: 2.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   6 VVLGTQWGDEGKGKIVDLLTERAKYVVRYQ-GGHNAGHTlVIN--GEKTVLHLIPSGILRENVI-SIIGNGVVLSPSALM 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHT-YIDdeGRKFVHRMLPNGIVSPPLKqVLIGPGSEIDLEVLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 KEMKGLEDRGIPVRERLLLSE-ACPLILDYHValdnaREKARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKATFAE 160
Cdd:NF038379  82 EEIEELEDAGHDVGKRLLIHEqATVIELHKHV-----EEEAGPMTKIGSTKKGIGAARAAKIRRNPSTLGDAEGDFGEGA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 161 KLKEVMEYHnfqlvnfykVEAVDYQkvlddvmaiadiltsmvvdvsdLLDQARKRGDFVMFEGAQGTLLDIDHGTYPYVT 240
Cdd:NF038379 157 VRDQPWEIA---------ERVVDNA----------------------LYDFALQAAERIQIEGTQGYSLGLHAGFYPYCT 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 241 SSNTTAGGVATGSGLGPRYVDY--VLGIIKAYSTRVGA-----GPFPTEL-FDDVGeflckQGNEYGATTGRRRRTGWLD 312
Cdd:NF038379 206 SRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGwsgnsYPDQGETtWEELG-----LPEELTTVTKKVRRVGTFS 280

                        330
                 ....*....|.
gi 489115757 313 SVAVRRAVQIN 323
Cdd:NF038379 281 AEQVREAVQAN 291
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 5-427 8.06e-26

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 110.14  E-value: 8.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757   5 VVVLGTQWGDEGKGKIVDLLTER--AKYVVRYQGGHNAGHTLVIN-GEKTVLHLIPSGILRENVISIIGNGVVLSPSALM 81
Cdd:PTZ00351 172 IMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSFM 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757  82 -KEMKGLEDRGIPVRERLLLSEACpLILDYHVALDnarekARGEKAIGTTGRGIGPAYEDKVARRGLRVGDLF-DKATFA 159
Cdd:PTZ00351 252 eKEIIQLIDAGIDYRDRLFIGNVC-IVTPYHKLLD-----LLGSAANSSTLKGMAPVHGSKVMKRGIRLDHIFnDDETLR 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 160 EKLKEVMEYH----------NFQLVNFYKVEAVD-YQKVLDDVMAIA------DILTSMV-------------VDVSDLL 209
Cdd:PTZ00351 326 KRLEKDMDTYlgllkvknlsDADVVRLCREENSDgVVRVPDYVIAFAqakdkvEFLVKLYrdrvrhnpdfparCDVTYEL 405

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 210 DQARKRGDFVMFEGAQGTLLDIDHGTY-PYVTSSNTTAGGVATGSGLG-PRYVDYVLGIIKAY-STRVGAG--------- 277
Cdd:PTZ00351 406 HAAVLRGEKVLLEGPQSYWLSNARTKFwESTTSADTTAAGLLAASQLNfQKFKSVVLNVHKAPgSSRVGIGacpssfvpq 485

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 278 ----------------------------------PF------------PTELFDDVGEF---------LCKQGNEYGATT 302
Cdd:PTZ00351 486 dyfsaqniktlrdlpsatcanfeavqrtlfrdgfPHsndkarhngimaPVEYSDETGDYnigvamaiaSAQHHGECGAVT 565

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489115757 303 GRRRRTGWLDSVAVRravQINSLSGFCLT--KLDVLDGLKEVKICVAYRM--PDGREVTTT--------------PLAAD 364
Cdd:PTZ00351 566 KKPRVCGFFDCVLQH---EVNSIQGPYLTisALDRGDEYDKVGVTIAYVYynPEGKQVDVNghvykngdiiragdPVPSE 642

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489115757 365 D-WKGIEPIYETMPGWSESTFGVKER---SGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILR 427
Cdd:PTZ00351 643 PaLYHCHPIVKLIDGWRDNPIAAAKRrrnAPLPRGVCELLSTIEYFTNCKILSIGNGPNGDDIIYLR 709
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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