|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-411 |
1.85e-83 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 259.81 E-value: 1.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 11 WWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWG 90
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVA-APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 91 ACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREM 170
Cdd:cd17319 80 LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 171 FIIEGFPAIIWAFCWWVLVkdkpsqvgwlsesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGF 250
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 251 VLWLPSIIRNGGaNLGMVEVGWLSSVPYLAATAAMILVSWASDKL--QNRKLFVWPLLLIAAFAFIGswAVGADHFWISY 328
Cdd:cd17319 199 LTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLL--AYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 329 TLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
...
gi 489114428 409 LVV 411
Cdd:cd17319 356 LLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-411 |
3.48e-67 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 219.13 E-value: 3.48e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 20 ITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMV 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFA-APMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 100 SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAI 179
Cdd:TIGR00893 80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 180 IWAFCWWVLVKDKPSQVGWLSESEKAALQAQLEKEQQGIKAVRNYS----EAFRSRNVILLCMQYFTWSIGVYGFVLWLP 255
Cdd:TIGR00893 160 IWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKyqikELLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 256 SIIRNGGAnLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNR--KLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVI 333
Cdd:TIGR00893 240 TYLVQERG-LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 334 AGAAMYAPY--GPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:TIGR00893 319 VALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-413 |
2.30e-60 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 200.10 E-value: 2.30e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 9 KRWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLIL 88
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 89 WGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWR 168
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 169 EMFIIEGFPAIIWAFCwwvlvkdkpsqvgwlsesekaalqaqlekeqqgikavrnyseafrsrNVILLCMQYFTWSIGVY 248
Cdd:COG2271 165 AAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVYFALY 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 249 GFVLWLPSIIRNGGaNLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKlfVWPLLLIAAFAFIGSWAVG-ADHFWIS 327
Cdd:COG2271 198 GFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR--KLVLAIGLLLAALALLLLAlLPSPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGsPSASYIFMGVALFVSVWL 407
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALL 353
|
....*.
gi 489114428 408 TLVVKP 413
Cdd:COG2271 354 ALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-412 |
3.50e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 177.00 E-value: 3.50e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 9 KRWWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLIL 88
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVL-APPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 89 WGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWR 168
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 169 EMFIIEGFPAIIWAFCWWVLVKDKPSQVgwlSESEKAALQAQLekeqqgikavrnysEAFRSRNVILLCMQYFTWSIGVY 248
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGA---AAAAKASLRDQL--------------EALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 249 GFVLWLPSIIRNgGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGAdhFWISY 328
Cdd:COG2223 223 GFSSWLPPYLVD-QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS--LWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 329 TLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLT 408
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
....
gi 489114428 409 LVVK 412
Cdd:COG2223 380 LLLY 383
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-338 |
3.17e-41 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 150.86 E-value: 3.17e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 12 WYIMPIVFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGA 91
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTvlwmSVVSGYLIQAL------ 165
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG----SIFGGLLAYGVfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 166 ----GWREMFIIEGFPAIIWAFCWWVLVKDKPSQVGWLSESEKAALQAQLEKEQQG-------IKAVRnysEAFRSRNVI 234
Cdd:cd17327 160 gglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGkgdqkfkWKQIK---EAFKDPRTW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 235 LLCMQYFTWSIGVYGFVLWLPSIIRNGGANLgmVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFV--WPLLLIAAFA 312
Cdd:cd17327 237 LLFLFFFCSQITNNGISNFLPLILKSLGFYS--LQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAifACVLALVGSI 314
|
330 340
....*....|....*....|....*.
gi 489114428 313 FIGSWAVGADHFWISYTLLVIAGAAM 338
Cdd:cd17327 315 ILLAAPNPPGAYFAAYILGGGSYAGF 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-377 |
3.94e-37 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 138.32 E-value: 3.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 18 VFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTG 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 98 MVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFP 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 178 AIIWAFCWWVLVKDKPSqvgwlsesekaalQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMqYFTWSIGVYGFVLWLPSI 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES-------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 258 IrnGGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAA 337
Cdd:pfam07690 227 Q--EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489114428 338 MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-383 |
9.63e-30 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 118.63 E-value: 9.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGM 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPY-LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 99 VSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL--------ILGNPVTVLWMSvvsgyliQALGWREM 170
Cdd:TIGR00881 80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWncshnvggGLLPPLVLFGIA-------ELYSWHWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 171 FIIEGFPAIIWAFCWWVLVKDKPSQVG------WLSEsEKAALQAQLEKEQQGIKAVRNYseAFRSRNVILLCMQYFTWS 244
Cdd:TIGR00881 153 FIVPGIIAIIVSLICFLLLRDSPQSCGlppaeeMPNE-EPDGDAEKKEEELTKKQIFLQY--VLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 245 IGVYGFVLWLPSIIRNgGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAA--FAFIGSWAVGAD 322
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQ-EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALiiVSLLVYWLNPAA 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489114428 323 HFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00881 309 NPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-373 |
4.49e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 116.23 E-value: 4.49e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 5 TNAAKRWWYIMPIVFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFV 84
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 85 CLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQA 164
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 165 LGWREMFIIEGFPAII-WAFCWWVLVKDKPSQVGwlsesekaalqaqlekeqqgiKAVRNYSEAFRSRNVILLCMQYFTW 243
Cdd:COG2814 161 FGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA---------------------RLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 244 SIGVYGFVLWLPSIIRNgGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWavgADH 323
Cdd:COG2814 220 GFGFFALFTYLPLYLQE-VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489114428 324 FWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGS 373
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-409 |
3.05e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.75 E-value: 3.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 18 VFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTG 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 98 MVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQAL--GWREMFIIEG 175
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 176 FPAIIWAFCWWVLVKDKPSQvgwlsesekaalQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLP 255
Cdd:cd06174 160 ALALLAAILLLLVVPDPPES------------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 256 SIIRNGGANLGmVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgADHFWISYTLLVIAG 335
Cdd:cd06174 228 LFLLDLGGLSV-AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489114428 336 AAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-412 |
7.05e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.74 E-value: 7.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSQvgwlse 201
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 202 sekaalqaQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPS-IIRNGGANLGMveVGWLSSVPYLA 280
Cdd:cd17325 178 --------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQ--IGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 281 ATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAiipEMLPRNVAGG 360
Cdd:cd17325 248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA---DIVPPEGRGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489114428 361 AMALINSMGALGSFFGSWFVGYLNgATGSPSASYIFMGVALFVSVWLTLVVK 412
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
47-383 |
3.18e-25 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 106.16 E-value: 3.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 47 TKGIssLLGAlFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNI--PMLAAIRFILGVVEAAVMPAML 124
Cdd:cd17318 57 TQGI--ILSS-FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVkdkpsqvgwlsesek 204
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 205 aalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFVLWLPSIIRN-GGANLGmvEVGWLSSVPYLAATA 283
Cdd:cd17318 199 --------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDvLHFNIK--SNGFLSSLPYLAMWI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 284 AMILVSWASDKLQN---------RKLF-VWPLLLIAAFAFIGSWavGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEML 353
Cdd:cd17318 251 CSIVGGYLADWLRSrgilstttvRKLFtSIGFLGPGVFLIALGY--LGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLA 328
|
330 340 350
....*....|....*....|....*....|
gi 489114428 354 PrNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17318 329 P-NYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-411 |
4.70e-25 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 105.73 E-value: 4.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSeRSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSqvgwl 199
Cdd:COG2807 124 NVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA----- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 200 sesekaalqaqlekEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGanLGMVEVGWLSSVPYL 279
Cdd:COG2807 198 --------------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG--LSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 280 AATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISytlLVIAGAAMYAPYGPFFAIIPEMLPR-NVA 358
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLW---AVLLGLGQGGLFPLALTLIGLRARTpAEA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489114428 359 GGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:COG2807 339 AALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-383 |
1.54e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 101.66 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 10 RWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILW 89
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPA-ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 90 GACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWRE 169
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 170 MFIIEG-FPAIIWAFCWWVL-------VKDKPSQVGW--------LSESEKAALQAQLEKEQQGIKAVRNYSEAFRSRNV 233
Cdd:TIGR00895 173 LFYVGGiAPLLLLLLLMRFLpesidflVSKRPETVRRivnaiapqMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 234 ILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGMVeVGWLSSVpYLAATAAMILVSWASDKLQNRKLFVWPlLLIAAFAF 313
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLA-ATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLL-LLGAVFAV 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 314 IGSWAVGADHfwISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00895 330 LVGSTLFSPT--LLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-411 |
9.25e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 99.23 E-value: 9.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 16 PIVFITYSLAYLDRanFSFASAAG-INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACAS 94
Cdd:cd17328 2 AVLFLINLLNYMDR--FTIAGVLPdIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 95 LTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQA-LGWREMFII 173
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 174 EGFPAIIWAFCWWVLVKDKPSQVgwlsESEKAALQAQLEKEQQGIKAVrnyseaFRSRNVILLCMQYFTWSIGVYGFVLW 253
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGA----AEGGVMAKSTATSFLADLKAL------AKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 254 LPSIIRNGGANLGMVEV---GWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPL-----LLIAAFAFIGSWAVGADHFW 325
Cdd:cd17328 230 APTFFLRAFGVGDLSSAdvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLvcavgLLAAAPFLFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 326 ISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMG-ALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVS 404
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLShLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
....*..
gi 489114428 405 VWLTLVV 411
Cdd:cd17328 390 LLLCSFV 396
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-405 |
5.12e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 96.52 E-value: 5.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 17 IVFITYSLAYLDRANFSFASAA-GINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASL 95
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVlAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 96 TGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAlgllQSGWALGALLAALVASLLIPLLSGDWGWRILF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 172 IIEGFPAIIWAFCWwvlvkdkpsqvgwlsesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFV 251
Cdd:cd17316 163 LIGALPALLALLLR---------------------------------------------RRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 252 LWLPSIIRNGGaNLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIgSWAVGADHFWISYTLL 331
Cdd:cd17316 198 TFLPTYLQTVL-GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP-LFYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489114428 332 VIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSV 405
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-404 |
4.48e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 94.15 E-value: 4.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSqvgwl 199
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 200 sesekaalqaqleKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGMVEVGWLSSVpYL 279
Cdd:cd17324 180 -------------KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLF-GV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 280 AATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWavgADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAG 359
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489114428 360 GA---MALINSMGALGSFFGSWFVGYLnGATGSPSASYIFMGVALFVS 404
Cdd:cd17324 323 ASslyLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLA 369
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
19-389 |
7.30e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 93.39 E-value: 7.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGM 98
Cdd:cd17380 5 FLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 99 V--SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGF 176
Cdd:cd17380 84 LaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 177 PAIIWAFCWWVLVKdkpsqvgwlsesekaalqaqlekeqqgikavrnyseAFRSrnvILLCmqYFTWSIGVYGFVLWLPS 256
Cdd:cd17380 164 LGLLWALVWLIYLP------------------------------------PVWA---IIVA--HFCMNWGFYILLSWLPT 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 257 IIRNGGANLGmvEVGWLSSVPYLAATAAMILVSWASDKLQN--------RKLF-VWPLLLIAAFAFIGSWavgADHFWIS 327
Cdd:cd17380 203 YFHEVLVPLA--KGWVFNVVPWLVMFPSSNVAGWLADHLISrgwtvtsvRKLMqSIGFLGPALFLLLLSH---TDSFSLA 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489114428 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSMGALGSFFGSWFVGYLNGATGS 389
Cdd:cd17380 278 LLCMSVALGLSAFSSSGVLVNHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGS 338
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
18-411 |
2.62e-20 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 92.30 E-value: 2.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 18 VFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTG 97
Cdd:cd17345 8 IFIGYAGYYLVRNNFSLAQP-YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 98 MV----SNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGN-------PVTVLWMSVVSGyliqALG 166
Cdd:cd17345 87 FVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHnvggglvGPLAGLGLAIFG----DGW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 167 WREMFIIEGFPAIIWAFCWWVLVKDKPSQVG------WLSESEKAALQAQLEKEQQGIKAVRNYseAFRSRNVILLC-MQ 239
Cdd:cd17345 163 WRGAFIFPAIIAIIVAVIVLFLGKDTPESEGlppieeYKGDYPEEADGEEEEQELSAWEIFVKY--VLKNKLLWYIAiAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 240 YFTWSIGvYGFVLWLPSIIRNgGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQ--NRKLFVWPLLLIAAFAFIGSW 317
Cdd:cd17345 241 VFVYLVR-YGILDWAPTYLSE-VKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 318 AvgADHFWISYTLLVIAGAAMyapYGPFFAI---IPEMLPRNVAGGAMALINSMGAL-GSFFGSWFVGYLNGATGSpSAS 393
Cdd:cd17345 319 L--APNVLVDLIALIALGFLI---YGPVMLIglqALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGW-NGG 392
|
410
....*....|....*...
gi 489114428 394 YIFMGVALFVSVWLTLVV 411
Cdd:cd17345 393 FIVLLASCILAIIFLALV 410
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-411 |
6.92e-20 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 90.41 E-value: 6.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 12 WYIMPIVFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGA 91
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKP-PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 172 IIEGFPAIIWAFCWWVLVKDKPSQvgwlsesekaalqaqlekeqqgikavrnyseafrsrnVILLCMQYFTWSIGVYGFV 251
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSPPY-------------------------------------VWVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 252 LWLPSIIrNGGANLGMVEVGWLSSVPYLAATAAMILVSWASDKL--QNRKLFVWPLLLIAAFAFIGSWAVGADhFWISYT 329
Cdd:cd17312 204 DWGPLYL-YEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHN-KLLSIV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 330 LLVIAGAAMYAPYGPFFAIIPEMLPR-NVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17312 282 LLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLL 361
|
...
gi 489114428 409 LVV 411
Cdd:cd17312 362 SLW 364
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-411 |
9.88e-20 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 89.95 E-value: 9.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 37 AAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVE 116
Cdd:cd17365 22 APALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 117 AAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAfcwwVLVkdkpsqv 196
Cdd:cd17365 102 GAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL----PLL------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 197 gwlsesekaalqaqlekeqqgikavrnyseafrsRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGmvEVGWLSSV 276
Cdd:cd17365 171 ----------------------------------RGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLS--QALTITLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 277 PYLAATAAMILVSWASDKLQNRKLFVWPLLLiaAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRN 356
Cdd:cd17365 215 LNIGGVIGSLLLGWLADRFGPKRVLALFFAL--GAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTE 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489114428 357 VAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:cd17365 293 VRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLL 347
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-409 |
1.18e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 89.99 E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 35 ASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGV 114
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 115 VEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVlvkdkps 194
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 195 qvgWLSESEKAALQAQLEKEqqgikAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGAnLGMVEVGWLS 274
Cdd:cd17475 170 ---FYREPPAASAATESAST-----LLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLG-LSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 275 SVPYLAATAAMILVSWASDKL--QNRKLFVWPLLLIAAFAFIG-SWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPE 351
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVlSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489114428 352 MLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
42-418 |
2.20e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.45 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 122 AMLIYISNWFTKSERSRANTFLILgNPVTVLWMSVVSGYLIQA---LGWREMFIIEGFPAIIWAFCWWvlvkdkpsqvgw 198
Cdd:COG0738 116 AANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 199 lseseKAALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGaNLGMVEVGWLSSVPY 278
Cdd:COG0738 183 -----RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL-GLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 279 LAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIgswAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvA 358
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL---ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-T 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 359 GGAMALINSMGALGSFFGSWFVGYLNGATGsPSASYIFMGVALFVSVWLTLVVKPANNQQ 418
Cdd:COG0738 333 AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-405 |
7.02e-16 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 79.40 E-value: 7.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 58 FFLGYFFFQIPGAIYAERRSVRKLIFVCLilwgACASLTGMVS------NIPMLAAIRFILGVVEAAVMPAMLIYISNWF 131
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGM----FLSSVISIVIpwaaggGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 132 TKSERSRANTFLILGNPVTVLWMSVVSGYLIQA-LGWREMFIIEGFPAIIWAFCWWVLVKDKPSQVGWLSESEKAALQAQ 210
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 211 LEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIrNGGANLGMVEVGWLSSVPYLAATAAMILVSW 290
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFI-SWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 291 ASDKLQNRKLFVwpllLIAA---FAFIGSWAVGA---------DHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRnVA 358
Cdd:TIGR00894 320 LADFLKSSKTLS----LTAArkiFNGIGGLGPGIfayalpylsAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPR-FL 394
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489114428 359 GGAMALINSMGALGSFFGSWFVGyLNGATGSPSASYIFMGVALFVSV 405
Cdd:TIGR00894 395 GFIKGITGLPGFIGGLIASTLAG-NILSQDSKNVWLIVFLIMAFVNI 440
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-408 |
3.57e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 76.52 E-value: 3.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGA-CASLTGMVSNIPMLAAIRFILGVVEAA 118
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 119 VMPAMlIYISNWFTKSERSRANTFLI----LGNPVTVLWMSVVSGYLIQA---LGWREMFIIEGFPAIIWAFCWWVLVKD 191
Cdd:cd17341 105 FASGQ-PWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFDggfVGWRNAFFVPGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 192 KPSQVGWLSESEKAALQAqlekeqqgikavrnyseaFRSRNVILLCMQYFtWSIGVY-GFVLWLPSIIRNGgANLGMVEV 270
Cdd:cd17341 184 LPTGKASALEFLKVQLAV------------------LKNYRTWILSLLYG-VTFGSFvGFSNVLPTYFKTR-FGLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 271 GWLSSVPYLAATAAMILVSWASDKLQNRK--LFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAI 348
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRM 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 349 IPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17341 324 VPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-411 |
8.50e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 8.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 73 AERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNP 148
Cdd:cd17473 59 ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqSAAMSLGGV 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 149 VTVLwmsvVSGYLIQaLGWREMFIIEGFPAIIWAFCWWVLVKDKPsqvgwlSESEKAALQAQLEKeqqgikavrnyseAF 228
Cdd:cd17473 139 VFLL----LGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPAR------KSKSAASPGAATAA-------------AL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 229 RSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGaNLGMVEVGWLSSVpylaATAAMILVSWASDKLQNRKLFVWPLLLI 308
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAI----ASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 309 AAFafigsWAVGADHFWISYTLLVIAGAAMYAPYG-----PF-FAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGY 382
Cdd:cd17473 270 FAL-----MALGFLLLALASGLWVVLLGAILAGLGfglllPTlNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
330 340
....*....|....*....|....*....
gi 489114428 383 LNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:cd17473 345 LVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-409 |
4.27e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 73.49 E-value: 4.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGM 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPA-LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 99 VSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQAL----GWREMFIIE 174
Cdd:cd17371 84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 175 GFPAIIwafCWWVLVkdkpsqvgWLSESEKAAlQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVL-W 253
Cdd:cd17371 164 ALPALL---VLFIRR--------FVKEPPQWQ-AARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITtW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 254 LPSIIRnGGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFvwpllliaAFAFIGSWAVGADHFWI--SYTLL 331
Cdd:cd17371 232 LPSYLT-GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF--------ALFALGSAISILLYFFLplSPTLI 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 332 VIAGAA----MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWL 407
Cdd:cd17371 303 LILGFPlgffASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
..
gi 489114428 408 TL 409
Cdd:cd17371 383 AL 384
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-410 |
1.20e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.88 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 52 SLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASL-----TGMVSNIPMLAAIRFILGVVEAAVMPAMLIY 126
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVlallaLLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 127 ISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSQVGwlsesekaa 206
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 207 lqaqlEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGMVEVGWLSSVPYLAATAAMI 286
Cdd:cd06173 188 -----ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 287 LVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVgadHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALIN 366
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489114428 367 SMGALGSFFGSWFVGYLNGATGsPSASYIFMGVALFVSVWLTLV 410
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
42-409 |
1.73e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.43 E-value: 1.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 122 AMLIYISNwFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPsqvgwlse 201
Cdd:cd17478 104 EGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 202 sEKAALQAQLEKEQQGIKAVRnyseafrsRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLgmVEVGWLSSVPYLAA 281
Cdd:cd17478 175 -PEAKKAAAKSSARSTLKGVW--------RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL--VFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 282 TAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGadhfWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV---A 358
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILLVLAGFLLFASFPVTVVLAQELLPGNVglaS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 489114428 359 GGAMALINSMGALgsffGSWFVGYLNGATGSPSAsYIFMGVALFVSVWLTL 409
Cdd:cd17478 320 GLMMGLSFGLGGI----GAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-291 |
1.84e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 70.61 E-value: 1.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 2 NSSTNAAKRWWYIMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKL 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 82 IFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYL 161
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 162 IQALGWREMFIIEGFPAIIwAFCWWVLVKDKPSQVGWLSESEKAALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYF 241
Cdd:COG0477 162 VAALGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489114428 242 TWSIGVYGFVLWLPSIIRNGGANLGMVEVGWLSSVPYLAATAAMILVSWA 291
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-411 |
2.07e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLI-YISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSqvgw 198
Cdd:cd17355 109 LAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPA---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 199 lsesEKAALQAQLEKEQQGIKAVRnysEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGanLGMVEVGWLSSVPY 278
Cdd:cd17355 185 ----DLALRAYDDASPASPGSTLK---EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG--ISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 279 LAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLViaGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWGATVPLTAALAARYFGARSY 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489114428 359 GGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:cd17355 334 GTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-412 |
3.70e-11 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 64.25 E-value: 3.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06180 27 AELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSV-VSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKPSQVGWLS 200
Cdd:cd06180 107 FGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLlVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 201 ESEKAalqaqlekeqqgikavrnyseAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGAnlGMVEVGWLSSVPYLA 280
Cdd:cd06180 187 AAESA---------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGA--GSLLAGLLWSLFGLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 281 ATAAMILVSWASDKLQNRKLFVWPLLliaafafIGSWAVGADHFWISYTLLVIaGAAMYApyGPFFAIIPEMLPR----- 355
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRALAANLL-------VQAVGVLLPLLSPGPAGLVL-SAVLFG--GTFMAITALVMALarela 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489114428 356 -NVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVVK 412
Cdd:cd06180 314 pPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-412 |
5.99e-11 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 63.78 E-value: 5.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 64 FFQIPGAIYAERRSVRKL-IFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISnWFTKSERSRANTF 142
Cdd:cd17490 46 LLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 143 LILGNPVTVLWMSVVSGYLIQALGWREMF---IIEGFPAIIWAFcwwvLVKDKPsqvgwlsesekaalqaqlEKEQQGIK 219
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSL----FIKEER------------------REKKPVLT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 220 AVRNYSEAFRSRNVIL-----LCMQYFTWSiGVYGFVlwlPSIIRNGGANLGmvEVGWLSSVPYLAATAAMILVSW-ASD 293
Cdd:cd17490 183 ELKELLSVLKDKKLLFfsllaILQQMITFS-TTFGFT---PLIAKQLGASSF--QLGLLSIIYLLPNALASLLSGTlFYK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 294 KLQNRKLFVWPLLLIAAFAFIgswAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGS 373
Cdd:cd17490 257 KLGERNTIIIGFLLLGAYCFL---IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGM 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 489114428 374 FFGSWFVGYLNGATGSpSASYIFMGVALFVSVWLTLVVK 412
Cdd:cd17490 334 FLGPVLVGIISEAFGL-QTGFFVIGVIALLAAILSLAYY 371
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
6-378 |
1.05e-10 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 63.19 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 6 NAAKRWW--YIMPIVFITYSLAYLDRANFSFASAAGINeDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIF 83
Cdd:PRK11663 14 DARYRYWrrHILITMYLGYALFYFTRKSFNAAMPEMLA-DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 84 VCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSER----SRANTFLILGNPVTVLwmsvVSG 159
Cdd:PRK11663 93 IGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERggwwAIWNTAHNVGGALIPL----VVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 160 YLIQALGWREMFIIEGFPAIIWAF--CWwvLVKDKPSQVGWLS--ESEKAALQAQLEKEQQGI---KAVRNYseAFRSRN 232
Cdd:PRK11663 169 AIALHYGWRYGMMIAGIIAIVVGLflCW--RLRDKPQAMGLPSvgEWRHDALELAQQQEGAGLsrkEILTKY--VLLNPY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 233 VILLCMQYFTwsigVYgfvlwlpsIIR---NGGANLGMVEVGWLSSVPYLAATAAM--------ILVSWASDKL--QNRK 299
Cdd:PRK11663 245 IWLLSFSYVL----VY--------VVRaaiNDWGNLYMSETLGVDLVTANSAVSMFelggfigaLVAGWGSDKLfnGNRG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 300 lfvwPLLLIAA---FAFIGS-WAVGADHFWISYTLLVIAGaamyapygpFFAIIPEML---------PRNVAGGAMALIN 366
Cdd:PRK11663 313 ----PMNLIFAagiLLSVGSlWLMPFASYVMQAACFFTIG---------FFVFGPQMLigmaaaecsHKEAAGAATGFVG 379
|
410
....*....|..
gi 489114428 367 SMGALGSFFGSW 378
Cdd:PRK11663 380 LFAYLGAALSGY 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-409 |
1.32e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRAntfliLGNPVTVLWMSVVSGYLIQAL----GWREMFIIEGFPAIIWAFCWWVLVKDKPSQ 195
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKA-----MGLYEAALGLGIAVGPLLGGLlaaiSWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 196 VGWLSESEKAALqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNgGANLGMVEVGWLSS 275
Cdd:cd17474 180 AKSSSATKLRDL-----------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL-LYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 276 VPylaaTAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGS--WAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEML 353
Cdd:cd17474 242 GW----SVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSllLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489114428 354 PRNVAGGAMALINSMGALGSFFGSWFVGYLnGATGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-403 |
4.80e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 4.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 79 RKLIFVCLILWGACASLT------GMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKS-ERSRANTFLILGNPVTV 151
Cdd:COG2211 81 RPWILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 152 LWMSVVSGYLI------QALGWREMFIIEGFPAIIWAFCWWVLVKDKPSqvgwlsesekaalqaqleKEQQGIKAVRNYS 225
Cdd:COG2211 161 LLASVLPPPLVaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------------------PEEEKVSLKESLK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 226 EAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNggaNLGMVE--VGWLSSVPYLAATAAMILVSWASDKLQNRKLFVW 303
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY---VLGLSAalVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 304 pLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLP-------RNVAGGAMALINSMGALGSFFG 376
Cdd:COG2211 300 -GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALA 378
|
330 340 350
....*....|....*....|....*....|..
gi 489114428 377 SWFVGYLNGATG-----SPSASYIFMGVALFV 403
Cdd:COG2211 379 GALAGLLLALFGyvagaAQSPSALTGIRLLFF 410
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-405 |
8.12e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 60.33 E-value: 8.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFcwwvLVKDKPSQVGWL 199
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIY----IRARAPESKEWE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 200 SESEK---AALQAQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFvlwLPSIIRNGGANLGMVEVgwLSSV 276
Cdd:PRK12307 200 EAKLSgkgKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGL---LPTYLAGEGFDTGVVSN--LMTA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 277 PYLAATAAMILVSWASDKLQNRKLFVwpLLLIAAFAFI---------GSWAVGADHFWISYTLLVIAGAAmyapygPFFa 347
Cdd:PRK12307 275 AAFGTVLGNIVWGLCADRIGLKKTFS--IGLLMSFLFIfplfripqdNYLLLGACLFGLMATNVGVGGLV------PKF- 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489114428 348 iIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGspsasyifMGVALFVSV 405
Cdd:PRK12307 346 -LYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMG--------LGAALTFIV 394
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-409 |
1.77e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 58.75 E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 50 ISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISN 129
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 130 WFTKSERSRANTFLILGNPVTVLWMSVVsGYLIQAlgWREMFIIEGFPAIIWAFCWWVLvkdkpsqvgwlsesekaalqa 209
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALL-AYLIRD--WRWLQLAISLPGLLFLLLLWWL--------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 210 qlekeqqgikavrnyseafrSRNVILLCMQYFTWSIGVYGFVLwlpsIIRNGGANL-------GMVEVgwlssvpyLAAT 282
Cdd:cd17317 162 --------------------PRRTIIVGLIWFVTSLVYYGLSL----NSSNLGGNLylnfflsGLVEI--------PAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 283 AAMILVSWAsdklqNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAM 362
Cdd:cd17317 210 LALLLLDRL-----GRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGV 284
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489114428 363 ALINSMGALGSFFGSwFVGYLngATGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17317 285 GLCSTVARVGAILAP-FIVLL--GKIGPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
40-408 |
4.87e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.59 E-value: 4.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF-IIEGFPAIIWAFCWWVLVKDKPSqvgw 198
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPETLPE---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 199 lsESEKAALQAQLekeqqgikavRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGaNLGMVEVGWLSSVPY 278
Cdd:cd17320 181 --EKRKPLLSSLL----------RAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQL-GLSPAQFGLLFALNA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 279 LAATAAMILVSWASDKLQNRKLFVW--PLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRn 356
Cdd:cd17320 248 IALILGSLLNGRLVRRFGPRRLLRLglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH- 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489114428 357 VAGGAMALINSMGALGSFFGSWFVGYLNGATGSP-SASYIFMGVALFVSVWLT 408
Cdd:cd17320 327 VAGTASALLGFLQFLIGALAGALVGLLPNGTALPmGLLILVLGLLALLLLILL 379
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-404 |
8.75e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 8.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPML-AAIRFILGVVEAAVM 120
Cdd:cd17352 31 EEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 121 PAMLIYISNWFTKsERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCwwvlvkdkpsqvgwls 200
Cdd:cd17352 111 SPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 201 esekAALqaqlekeqqgikavrnySEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANlgMVEVGWLSSVPYLA 280
Cdd:cd17352 174 ----GLL-----------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGID--ESDAAFLLSIIGIS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 281 ATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVgADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGG 360
Cdd:cd17352 231 DIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSN 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489114428 361 AMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVS 404
Cdd:cd17352 310 AYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLS 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
228-412 |
2.55e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.37 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 228 FRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGMVevGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLL 307
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 308 IAAFAFIGSWAvgaDHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGAT 387
Cdd:COG2814 85 FALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....*
gi 489114428 388 GSPSASYIFMGVALFVSVWLTLVVK 412
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-416 |
2.59e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 269 EVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGadhFWISYTLLVIAGAAMYAPYGPFFAI 348
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS---LWLLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489114428 349 IPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVVKPANN 416
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES 177
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-420 |
7.18e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 54.25 E-value: 7.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 53 LLGALFFLGYFffqIPGAIY---AERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISN 129
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFgylSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 130 WFTKSERSRANTFLILGNPVTVLWMSVVsGYLIQalGWREMFIIEGFPAIIWAFCWWVLvkdkPSQVGWLSES---EKA- 205
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIP--DWRWLQLAVSLPTFLFFLLSWFV----PESPRWLISQgriEEAl 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 206 -----------------ALQAQLEKEQQGIKAVRNYSEAFRSRNV----ILLCMQYFTWSIGVYGFVLWLPSIIRNGGAN 264
Cdd:TIGR00898 281 kilqriakingkklpaeVLSLSLEKDLSSSKKQYSFLDLFRTPNLrkttLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLD 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 265 L---GMVEVgwlssvpylaatAAMILVSWASDKLQNRKLFVwPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAP 341
Cdd:TIGR00898 361 LfisGLVEL------------PAKLITLLLIDRLGRRYTMA-ASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSA 427
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489114428 342 YGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFgSWFVGYLNGAtgSPSASYIFMGVALFVSVWLTLVVKPANNQQLP 420
Cdd:TIGR00898 428 FQMVYLYTAELYPTVVRNLGVGVCSTMARVGSII-SPFLVYLGEK--WLFLPLVLFGGLALLAGILTLFLPETKGVPLP 503
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
236-413 |
7.95e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 7.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 236 LCMQYFTWSIGVYGFVLWLPSIIRNGGAnlGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGA--SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 316 SWAvgaDHFWISYTLLVIAGAAMyAPYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGsPSASY 394
Cdd:cd17325 79 AFA---TSYWQLLLARFLQGLAS-AAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF 153
|
170
....*....|....*....
gi 489114428 395 IFMGVALFVSVWLTLVVKP 413
Cdd:cd17325 154 LVCAALALLALVLALLLLP 172
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-407 |
8.37e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 53.76 E-value: 8.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 64 FFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFI--LGVVEAAVMPAMLIYISnwftksERSRANT 141
Cdd:cd17472 47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALqgSGAISSVVMALLADLTR------EENRTKA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 142 FLILGNPVTVLWM-SVVSGYLIQA-LGWREMFIIEGFPAII-WAFCWWVLVKDKPSQVGwlSESEKAALQAQLekeqqgi 218
Cdd:cd17472 121 MALIGASIGIAFAiSMVLGPLLAAhLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQI--SEKEKKKLKKLL------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 219 kavrnyseafRSRNVILLCMQYFTWSIGVYGFVLWLP---SIIRNGGANLGMVevgwlssvpYLAATAAMILVSWASDKL 295
Cdd:cd17472 192 ----------KNKRLLRLDFSIFILHFVLMAFFYILPlllTQLGGGKGQLWKV---------YLPAILIGFILMVPFVIY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 296 QNRKLFVWPLLLIA----AFAFIGSWAvGADHFWISYTLLVI--AGAAMYAPYGPffAIIPEMLPRNVAGGAMALINSMG 369
Cdd:cd17472 253 AEKKGKMKQVFVSSilliAVGFLLLLF-AATSLWLLIIGLIIffIGFNLLEALLP--SLVSKIAPKEYRGTAMGIYNTSQ 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 489114428 370 ALGSFFGSWFVGYLNgatGSPSASYIFMGVALFVSVWL 407
Cdd:cd17472 330 FLGSFLGGALGGLLW---GLLGYSSVFLTILILALLWL 364
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-405 |
8.38e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.75 E-value: 8.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 43 DLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIE-GFPAIIWAFCWwvLVKDKPSQVGWLSE 201
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAaVLALLALLLVF--LVKDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 202 SEKAALQaqlekeqqgikavrnyseAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIirngGANLGMVEVGWLSSVPYLAA 281
Cdd:cd17489 183 AGTRAFR------------------RLVEKKVLPPALILFLASIAYGAISTFLPLY----AAERGISNAGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 282 TAAMILVSWASDKLqNRKLFVWPLLLIAAFAFIGSWAvgADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGA 361
Cdd:cd17489 241 LLSRPFSGKLSDRK-GPKTVIIPGLLLLALGLLLLSF--AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489114428 362 MALINSMGALGSFFGSWFVGYLNGATGsPSASYIFMGVALFVSV 405
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLAL 360
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
12-197 |
8.91e-08 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 53.88 E-value: 8.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 12 WYIMPIVFITYSLAYLDRANFSFASAAGINEdLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGA 91
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMNE-LGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 92 CASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMF 171
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180
....*....|....*....|....*.
gi 489114428 172 IIEGFPAIIWAFCWWVLVKDKPSQVG 197
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVG 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
79-376 |
9.06e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 9.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 79 RKLIFVC-LILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVV 157
Cdd:cd17321 60 RKRVFLIgLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 158 SGYLIQALGWREMFIIEGFPAIIwafcwwVLVkdkpsqvgwlsesekaalqaqlekeqqgikavrnYSEAFRSRNVILLC 237
Cdd:cd17321 140 GGLLLELFGWRWIFLINVPIGLV------ALL----------------------------------LARTFSGAVLAAFL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 238 MqyftwSIGVYGFVLWLPSIIRNGGaNLGMVEVGwLSSVPYLAATAAMILVS-WASDKLQNRKLFVWPLLLIAAFAFIGS 316
Cdd:cd17321 180 L-----GAALGGLLFLLPLYLQGVL-GYSPLQAG-LALLPLALAMLVAAPLAgRLADRFGPRLVLVAGLLLTAVGLLLLA 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 317 WAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFG 376
Cdd:cd17321 253 LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-411 |
1.12e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.38 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLaairfILGVVEAAV 119
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLL-----FLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYIS------NWFtKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKP 193
Cdd:cd17353 104 IGAGIGYITpvstavKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 194 sqVGWLSESEKAALQAQLEKEQQgikavRNYSEAFRSRNVILLCMQYFT-WSIGVYGFVLWlpSIIRNGGANLGMVEVGW 272
Cdd:cd17353 183 --KGWVPPGVDPLANNAENSPRD-----YTPREMLRTPTFWLLWLMFFLnATAGLMLIGQA--KPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 273 LSSVPYLAATAAMILVSWASDKLqNRKLFVWPLLLIAAFAFIGSWAVGADhfwisYTLLVIAGAAMYAPYGPFFAIIPEM 352
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSV-----AVLFVLGVALIGFCYGGGFALFPAL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489114428 353 LPR----NVAGGAMALINSMGALGSFFGSwFVGYLNGATGSPSASYIFMGVALFVSVWLTLVV 411
Cdd:cd17353 328 TADffgtKNAGTNYGLLYTAKGVGGLIGP-IIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
279-405 |
2.06e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 52.91 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 279 LAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFW-ISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV 357
Cdd:cd17369 275 VVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWlIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRV 354
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 489114428 358 AGGAMAL-INSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSV 405
Cdd:cd17369 355 RYTGASLgYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISL 403
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-189 |
2.45e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.58 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIegfpAIIWAFCWWVLV 189
Cdd:cd17323 105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF----LAIISGFCLILI 170
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
73-377 |
4.64e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.42 E-value: 4.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 73 AERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVL 152
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 153 WMSVVSGYLIQALGWREMFIIegfPAIIWAFCWWVLvkdkpsqvgwlsesekAALQAQLekeqqgikavrnyseaFRSRN 232
Cdd:cd17503 135 IGPTLGGWLTDNLSWRWIFYI---NLPIGILALLLA----------------PLLDLRL----------------FKDRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 233 VILLCMQYFTWSIGVYGFVLWLPSIIRNGgANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFA 312
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNV-LGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489114428 313 FIGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd17503 259 LLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGT 323
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
47-188 |
5.27e-07 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 51.57 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 47 TKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILwgacASLTGMVSNIPM------LAAIRFILGVVEAAVM 120
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFV----TSTLNMLIPIAArvhygcVIFVRILQGLVEGVTY 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489114428 121 PAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVL 188
Cdd:cd17382 123 PACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-189 |
8.07e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 8.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 41 NEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVM 120
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489114428 121 PAMLIYISNWFTKSERSRA----NTFLILGNPVTvlwmSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLV 189
Cdd:cd17325 307 PATLALLADIVPPEGRGTAmglfNTAFSLGMVLG----PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
53-189 |
8.36e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.93 E-value: 8.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 53 LLGAlFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPM--LAAIRFILGVVEAAVMPAMLIYISNW 130
Cdd:cd17381 70 ILGS-FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489114428 131 FTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLV 189
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV 207
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
68-391 |
2.75e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 68 PGAIY----AERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL 143
Cdd:PRK11551 65 PGALLggrlADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 144 ILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAfcwwvlvkdkPSQVGWLSESEKAALQAQLEKEQQGIKAVRn 223
Cdd:PRK11551 145 YCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLV----------PLLMRWLPESRAFAQAAGAGKQRAPVLRAL- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 224 YSEAfRSRNVILLCMQYFTWSIGVYGFVLWLPSIIrnGGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKL--- 300
Cdd:PRK11551 214 FGEG-RATATLLLWISYFFTLIVLYFLLNWLPSLL--VGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVvll 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 301 -FVWPLLLIAAFAFIGSWAVgadhfwisyTLLVIAGAAMYAPYGP--FFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:PRK11551 291 iYAGILASLAALAAAPSFAG---------MLLAGFAAGLFVVGGQsvLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGP 361
|
330
....*....|....
gi 489114428 378 WFVGYLNGATGSPS 391
Cdd:PRK11551 362 LLAGQLLALGRSTV 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-199 |
3.27e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 48.94 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 14 IMPIVFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACA 93
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPA-MLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 94 SLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFII 173
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYV 162
|
170 180
....*....|....*....|....*.
gi 489114428 174 EGFPAIIWAFCWWVLVKDKPSQVgWL 199
Cdd:cd17488 163 PGIIAILMGIVLCWRLRDRPPYI-WL 187
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-407 |
3.30e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.71 E-value: 3.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 122 AMLIYISNWFTKSERSRantflILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVkdkpsqvgwlse 201
Cdd:cd17477 104 VSESWLNALATNENRGR-----VLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 202 sekAALQAQLEKEQQGIKAVRNYSeafrsRNVILLCMQYFTWSIGVYGFVLWLP-SIIRNGganLGMVEVGWLSSVPYLA 280
Cdd:cd17477 167 ---LTRRAAPEIEEAESISLRRLL-----RIAPLALLGAFVAGFLEGAFYSLLPlYGLRLG---LSVAQAALLLAAFVLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 281 ATAAMILVSWASDKLQNRKLFVWpLLLIAAFAFIGSWAVGAdHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGG 360
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLG-CALLGALAALLLPLVPG-LPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489114428 361 AMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWL 407
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
244-411 |
4.69e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 244 SIGVYGFVLWLPSIIRNGGanLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADH 323
Cdd:cd17339 209 SLLFYTLMAWLPTILIDAG--LSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTAL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 324 FWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMAliNSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFV 403
Cdd:cd17339 287 ALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMA--QSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
....*...
gi 489114428 404 SVWLTLVV 411
Cdd:cd17339 365 QLVAGLGA 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
265-426 |
2.66e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 265 LGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPygp 344
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL--- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 345 FFAIIPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVVKPANNQQLPIGAR 424
Cdd:COG2807 127 LPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA 205
|
..
gi 489114428 425 HA 426
Cdd:COG2807 206 AS 207
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
51-406 |
4.20e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 51 SSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTG---MVSNIPMLAAIRFILGVVEAAVMPAMLIYI 127
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGaakGKWSVYQLIVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 128 SNWFTKSERSRA----NTFLILGNPVTVlWMSVVSGYLIQALGWREMFIIEGFPAIIWAFC--------WWVLVKDKPSQ 195
Cdd:pfam00083 128 SEIAPKKLRGALgslyQLAITFGILLAY-IFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGllflpespRWLVEKGRLEE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 196 V------GWLSESEKAALQAQLEKEQQGIKAVRNY-SEAFRSRN--------VILLCMQYFTwsiGVYGFVLWLPSIIRN 260
Cdd:pfam00083 207 ArevlakLRGVPDVDRELDEIKDSLEAGQEAEKASwKELFSTKTrrqrlligVMLQIFQQLT---GINAIFYYSTTIFEN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 261 gganLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLL-LIAAFAFIGSWAVGADHFWISYTLLVIAGAAMY 339
Cdd:pfam00083 284 ----LGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAgMAICFVILGIVALLGVSKSDWAGIVAIVFIALF 359
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489114428 340 -APYGP-----FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVW 406
Cdd:pfam00083 360 iAFFAMgwgpvPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
229-410 |
4.23e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.19 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 229 RSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANLGMVevGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLI 308
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL--GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 309 AAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPYgpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATG 388
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGA---LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180
....*....|....*....|..
gi 489114428 389 SPSASYIFMGVALFVSVWLTLV 410
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRL 188
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
42-193 |
6.49e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAER--RSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVKDKP 193
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
243-407 |
1.17e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 243 WSIGVYGFVLwlPSIIRNGGANLGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGad 322
Cdd:cd17316 13 YDFFLIGFVA--PVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 323 hFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSA---SYIFMGV 399
Cdd:cd17316 89 -PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwriLFLIGAL 167
|
....*...
gi 489114428 400 ALFVSVWL 407
Cdd:cd17316 168 PALLALLL 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-188 |
1.22e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489114428 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVL 188
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
79-383 |
1.45e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.72 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 79 RKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVvEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVS 158
Cdd:cd17504 61 KKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 159 GYLIQALGWREMFIIeGFPAIIWAFCWWVLVKDKpsqvgwlsesekaalqaqlekeqqgikavrnyseAFRSRNVILLCM 238
Cdd:cd17504 140 GWIVQHLGWRWIFWT-AAPVAVLLAALVPLIDLR----------------------------------LLRRRNVLLANI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 239 QYFTWSIGVYGFVLWLPSII---RNGGANLGMVEVGWLssvpYLAATAAMILVSWASDKLQNRKLFvWPLLLIAAFAFIG 315
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLqlpTPTGFGLGITEAGLL----LLPGALVMLIAGPLAGRLIARVGP-RRVLLIGLVISAV 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489114428 316 SWAVGA---DHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17504 260 GLLLLAllhSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
42-190 |
1.74e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 42 EDLGITK---GISSLLGALFFLGYFFFqipGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAA 118
Cdd:cd17335 226 QDLGGSKtliGLLWTVGVVSEIPFFFF---SSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489114428 119 VMPAMLIYISNWFTKSERSRANTFL-ILGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWWVLVK 190
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
43-411 |
2.42e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 43.33 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 43 DLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYliqaLGWREMFIIEGFPAIIWAFCW--------WVLVKDKPS 194
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSF----LPWRTLALIGAIPPVVFLILLffipesprWLAKKGREE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 195 QV----GWL------SESEKAALQAQLEKEQQGIKAVRnYSEAFRSRN----VILLCMQYFTWSIGVYGFVLWLPSIIRN 260
Cdd:cd17358 191 EAekslQFLrgkdadISKEAAEIQEELAELEKEAKESS-FSDLFQRKYlkplVIGLGLMLFQQLSGINAVIFYASSIFDE 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 261 GG----ANLGMVEVGwlsSVPYLAATAAMILVswasDKLQNRklfvwPLLLI-AAFAFIGSWAVGAdHFWI--------S 327
Cdd:cd17358 270 AGsgldPNTATIIIG---VVQVVGTLVATLLV----DRLGRR-----PLLLVsAIGMGIGLLALGL-YFYLqehgallsS 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 328 YTLLVIAGAAMY-----APYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVAL 401
Cdd:cd17358 337 VSWLPLVGLVIYiisfsIGLGPlPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICG 416
|
410
....*....|
gi 489114428 402 FVSVWLTLVV 411
Cdd:cd17358 417 LALVFVLLFV 426
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
52-342 |
3.10e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 42.69 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 52 SLLGAL---FFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGM-----VSNIPMLAAIRFILGVVEAAVMPAM 123
Cdd:cd17344 62 ELLGALdsaFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 124 LIYISNWFTKSERSrantfLILGnpvtvLWMSVVS-----GYLIQAL----GWREMFIIegfPAIIWAF----CWWVLVK 190
Cdd:cd17344 142 VACVGNWFGKGKRG-----LIMG-----IWNSHTSvgnilGSLIAGIfvssAWGLSFIV---PGIIIAAmgvlVFLFLVE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 191 DKPsqvgwlsesekaalqaqlekeqqgikAVRNYSeafrsrnvilLCMqYFTWSIGvYGFVLWLPSIIRNgGANLGMVEV 270
Cdd:cd17344 209 HPP--------------------------GVIEFS----------LCL-FFAKLVS-YTFLYWLPLYISN-TAILSAKKA 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489114428 271 GWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIAGAAMYAPY 342
Cdd:cd17344 250 GDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPY 321
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
283-413 |
3.69e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.36 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 283 AAMILVSWA------SDKLQNRKLFVWPLLLIAAFAF-IGSWAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPR 355
Cdd:cd17368 267 AGVANFIWAplggalSDRIGRRPVLLVITLAALVTLYpVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPV 346
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489114428 356 NVAGGAMALINSMG-ALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSVWLTLVVKP 413
Cdd:cd17368 347 RVRSTGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATLMLRE 405
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
279-405 |
3.76e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 279 LAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIgswAVGADHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG---FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 489114428 359 GGAMALINSMGALGSFFGSWFVGYLnGATGSPSASYIFMGVALFVSV 405
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYL-WDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-401 |
6.81e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 52 SLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAVMPAMLIYISNWF 131
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 132 TKSERSR---ANTFLILGNPVTVLWMSVVsgyLIQALGWREMFIIEGFPAIIWAFCWWVLvkdkpsqvgwlsesEKAALQ 208
Cdd:cd17333 114 EESSATRlnvLHGFFGLGALIGPLIATSL---LTSELSWSWAYLIIGLIYLLLAILILLT--------------LFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 209 AQLEKEQQGIKAVRNYSEAFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGaNLGMVEVGWLSSVPYLAATAAMILV 288
Cdd:cd17333 177 SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK-HVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 289 SWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLviaGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSM 368
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL---GLFMAALFPTILSLGISNLPYA-KGKGTSVLLAA 331
|
330 340 350
....*....|....*....|....*....|...
gi 489114428 369 GALGSFFGSWFVGYLNGATGSPSASYIFMGVAL 401
Cdd:cd17333 332 GSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
234-377 |
1.58e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.69 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 234 ILLCMQYFTWSIGVYGFVLWLPSIIRNGGanlGMVEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAF 313
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG---PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489114428 314 IGSWAVGADHFWISYTLLVIAGAAMyapyGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGAGTQ----GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP 137
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-403 |
1.61e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.29 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMVSNIPMLAAIRFILGVVEAAV 119
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQaLGWREMFIIEGFPAIIWAFCWWVlvkdkpsqvgWL 199
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLF----------LL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 200 SESEKAALQAQLEKEQQGIKAVrnyseaFRSRNVILLCMQYFTWSIGVYGFVLWLPSIIRNGGANlGMVEVGWLSSVPYL 279
Cdd:cd17329 175 PETRPKRRAAEKTEILRGYKIV------LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL-GESLLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 280 AATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADHFWISYTLLVIaGAAMYAPYGPffAIIPEMLPRNVAG 359
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL-GEMLVFPAVQ--TLVAALAPPDKRG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 489114428 360 GAMALINSMGALGSFFGSWFVGYLngaTGSPSASYIFMGVALFV 403
Cdd:cd17329 325 SYMGFYALAWGLGRAIGPLVGGLL---LDLLGPGLPWLILAALG 365
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
50-406 |
2.58e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.29 E-value: 2.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 50 ISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVC-----LILWGACASLtgMVSNIPMLAAIRFILGVVEAAVMPAML 124
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVklfevGLTLLIVLAY--YLGWFWLAFAVTFLLGAQSAIYSPAKY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQALG-----------WREMFIIEGFPAIIWAFCWwvLVKDKP 193
Cdd:PRK08633 126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNgntpseilgriAPAGLVLLAVAVLGLIFAY--RLPKVP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 194 SQVGWLSESEKAALQAQLekeQQGIKAVrnyseafRSRNVILLC---MQYFtWSIGvygfVLWLPSIIRNGGANLGMVEV 270
Cdd:PRK08633 204 AAAPEVFDKKKYLFPKLL---WRNLKLL-------RSDRVLWLAiigLSYF-WFIS----QLAQANFPAYAKEVLGLDNT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 271 gWLSSVPYLAATAAMILVSWASDKLQNRK--LFVWPL--LLIAAFAFIGSWavgADHFWISYTLLVIAG--AAMYAPygP 344
Cdd:PRK08633 269 -FQVQYLLAASAIGIGIGSLLAGRLSGRHieLGLVPLgaLGLALSLFLLPT---APSLASVLVLFFLFGfsAGLFIV--P 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489114428 345 FFAIIPEMLPRNVAGGAMA---LINSMGALGSFFGSWFVGYLNgaTGSPSASYIFMGVALFVSVW 406
Cdd:PRK08633 343 LNALIQFRAPEKELGKVLAannFLQNVGMLLFLALTTLFSGLG--LSPAGLFYLIALVTLIGTLY 405
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-186 |
2.87e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 40 INEDLGITKGISSLLGALFFLGYFFFQIPGAIYAERRSVRKLIFVCLILWGACASLTGMV--SNIPMLAAIRFILGVVEA 117
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVG 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 118 AVMPAMLIYISNWFTKSERSRANTFLI-LGNPVTVLWMSVVSGYLIQALGWREMFIIEGFPAIIWAFCWW 186
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYnLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
253-424 |
3.90e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 253 WLPSIIRNGGANLGMVevGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgaDHFWISYTLLV 332
Cdd:cd17478 18 LLPLLIAKLGLSYAQA--GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 333 IAGA--AMYAPYGpffAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPsASYIFMGVALFVSVWLTLV 410
Cdd:cd17478 93 LAGIgsAAFHPEG---ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGL-GLLILLIIPGLAVALLLLR 168
|
170
....*....|....
gi 489114428 411 VKPANNQQLPIGAR 424
Cdd:cd17478 169 LRPLKKPEAKKAAA 182
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
254-410 |
4.95e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 254 LPSIIRNGGANLgmVEVGWLSSVpYLAATAAMI-LVSWASDKLQNRKLFvwpllLIAAFAF-IGSWAVGADHfwiSYTLL 331
Cdd:cd17503 19 LPTIMGDLGASL--DTVQWVITS-YLLALAIMIpLSGWLADRFGTRRLF-----LTALALFtLGSLLCGLAP---NLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 332 VIA------GAAMYAPYGpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFMGVALFVSV 405
Cdd:cd17503 88 IIFrilqgfGGGVLIPLA--QTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALL 165
|
....*
gi 489114428 406 WLTLV 410
Cdd:cd17503 166 LAPLL 170
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
270-420 |
5.66e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 5.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 270 VGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGADH--FWISYTLLVIAGAAMyAPYGP-FF 346
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlsLWLLLVLAFLLGIAS-AFFGPaRQ 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489114428 347 AIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGsPSASYIFMGVALFVSVWLTLVVKPANNQQLP 420
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
238-414 |
6.88e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.41 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 238 MQYFTWSIGVYGFVLWLPsIIRNGGANLGmvEVGWLSSVPYLAATAAMILVSWASDKLQNRKLFVWPLLLIAAFAFIGSW 317
Cdd:cd17355 11 ILILSWGIRYYFGVFIIP-IIAEFGWSRA--VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489114428 318 AVGADHFWISYTLLVIAGAAMYapYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGATGSPSASYIFM 397
Cdd:cd17355 88 ATSLWQLYLLWGLLGGGGAGTL--AAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLA 165
|
170
....*....|....*....
gi 489114428 398 GVALFVS--VWLTLVVKPA 414
Cdd:cd17355 166 LLALLVLvpVLLLLRRRPA 184
|
|
| |
