|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
2-393 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 579.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 2 TNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFI 81
Cdd:PRK03699 1 TNSNRIKLTWISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 82 LMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIE 161
Cdd:PRK03699 81 LMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 162 WYWVYACIGLVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYA-KSLGMSL 240
Cdd:PRK03699 161 WYWVYACIGLVYVAIFILTLFSEFPALGKHAPKADKPVAKEKWGIGVLFLAIAALLYILAQLTFISWVPEYAqKKFGMSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 241 NDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFI-TGTPEHMPWFILTLGFFSSAIYTTIITLGS 319
Cdd:PRK03699 241 EDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALVLMYLFVnTDDPSHLLYAILGLGFFSSAIYTTIITLGS 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489113740 320 QQTKVASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFILGFVTRHRQHNAPATH 393
Cdd:PRK03699 321 QQTKVASPKLVNFILTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFVMCILLGFVSKHRQHGALTAH 394
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-377 |
1.53e-75 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 238.76 E-value: 1.53e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 10 TWISFLSYALTGALVIVTGMVMGNiadYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAG 89
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEE---AFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 90 LMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQrGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYACI 169
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 170 GLVYVAIFLLTFGCEFPALGKHAQQ------SDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYAK-SLGMSLND 242
Cdd:cd17333 157 GLIYLLLAILILLTLFPELPSARNPqqsvgaFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVeKKHVSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 243 AGKLVSDFWMSYMVGMWAFSFILRFFdLQRILTVLAGLATVLMYLF--ITGTPEHMPWFILTLGFFSSAIYTTIITLGSQ 320
Cdd:cd17333 237 AGYLLSGFWVGITIGRLLGGPISRRI-KPHTLLVLSGSGALLGLLIllLAPTLVVGLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489113740 321 QTKVASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFI 377
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-385 |
7.04e-49 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 170.03 E-value: 7.04e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 1 MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGF 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 81 ILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYeGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLAR-- 158
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLgl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 159 SIEWYWVYACIGLVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGI---GVLFLAIAALCYILGQLGFISWVPEYAKS 235
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLknpRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 236 -LGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFITGTPEHMP-WFILTLGFFSSAIYTT 313
Cdd:COG0738 240 vLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLAlIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489113740 314 IITLGSQQTKVASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFILGFVTRHR 385
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-383 |
3.36e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 3.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 6 RIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVL 85
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 86 AVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIEWYWV 165
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-AFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 166 YACIGLVYVAIFLLTFgcefpalgkhaqqsdapvvkekwgigvLFLAIAALCYILGQLGFISWVPEYAKS-LGMSLNDAG 244
Cdd:COG2271 167 FLILGLPGLLLALLRF---------------------------WLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 245 KLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTIITLGSQQTKV 324
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489113740 325 ASPKLVN----FVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFILGFVTR 383
Cdd:COG2271 300 FPKKARGtasgLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-322 |
9.54e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 74.63 E-value: 9.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 2 TNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFI 81
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 82 LMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIE 161
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 162 WYWVYACIGLVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYAKS-LGMSL 240
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 241 NDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLF-ITGTPEHMPWFILTLGFFSSAIYTTIITLGS 319
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLaLAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
...
gi 489113740 320 QQT 322
Cdd:COG2814 323 ELA 325
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-334 |
1.52e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.91 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 14 FLSYALTGALVIVTGMVMGN-IADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLML 92
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 93 SHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIEWYWVYACIGLV 172
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 173 YVAIFLLTF------GCEFPALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYAKSLGMSLNDAGKL 246
Cdd:pfam07690 161 SLLAAVLLLlprpppESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 247 VSDFWMSYMVGMWAFSFIL-RFFDLQRILTVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTIITLGSQQTKVA 325
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSdRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
....*....
gi 489113740 326 SPKLVNFVL 334
Cdd:pfam07690 321 PKEERGTAS 329
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
64-330 |
1.76e-13 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 71.10 E-value: 1.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 64 AWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSL---ALFSAAMFVLGlvSGITM--SIGTFLVTQMYEGRQRGSRLLFTD 138
Cdd:cd17394 55 GMLIKRYGYKKGILLGLGLYAIGALLFIPAASLrtyGLFLIALFVLA--SGLALlqTAANPYVTVLGPEETAARRLNLAQ 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 139 SFFSMAGMIFPMVAAFLLARSIE------------------------WYWVYACIGLVYVAIFLLTFGCEFPALGK--HA 192
Cdd:cd17394 133 AFNSLGSTIAPLFGSYLILSGIPstatalaamsaaelqayktaelasVQLPYLGIALVLLLLAVLILLSKLPEIEAaeAE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 193 QQSDAPVVKEKWGIGVLFLAIAAL-CYILGQLGFISWVPEYAK--SLGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFD 269
Cdd:cd17394 213 ALGSKGTLLRLLKNPHLRLGVLAIfFYVGAEVAIWSFLINYLMeyIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKIS 292
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489113740 270 LQRILTVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTIITLG----SQQTKVASPKLV 330
Cdd:cd17394 293 PKKLLAVFALLGLLLLLGAIFTGGMVALYALVLVGFFNSIMFPTIFSLAlkglGKHTKTGSGLLV 357
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
14-379 |
9.72e-12 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 65.83 E-value: 9.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 14 FLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLS 93
Cdd:cd17396 6 YFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 94 HSLALfsaaMFVLGLVSGITMSigtFLVTQMYEG------RQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYA 167
Cdd:cd17396 86 PNLII----AYVFALLAGAANS---FLDTGTYPAlmeafpKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 168 CIGLVYVAIFLLTFGCEFP---ALGKHAQQSDAPVVKEKwgigvLFLAIAALCYILgqLGFIS---------WVPEYAKS 235
Cdd:cd17396 159 VPAAVLVLNALLLLKLSFPpqtVTAANTKQKEIPVKREK-----PKFLIEGIALIL--IGFTStatfylfsqWMPKYGSA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 236 -LGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFF----DLQRILTVLAGLATVLMYLFitGTPEHMPWFILTLGFFSSA- 309
Cdd:cd17396 232 vAGMGEAESLKLISYYSMGSLVCVFITAVLLKRYvrpiWILVLYPIISLLALFVLYLV--PSPDVCILGAFVIGFFAAGg 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 310 IYTTIITLGSQQTKVASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFILG 379
Cdd:cd17396 310 VLQLGLTLMAEFFPKGKGKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLLAIFVF 379
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-392 |
1.51e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 65.29 E-value: 1.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 4 SNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILM 83
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 84 VLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIEWY 163
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-AFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 164 WVYACIGLVYVAIFLLTF------GCEFPALGKHAQQSDAPVVKEKwgiGVLFLAIAALCYILGQLGFISWVPEYAKS-L 236
Cdd:COG2223 160 NAFLILGILLLVVAVLAWlflrdpPAGAAAAAKASLRDQLEALRDP---RFWLLSLLYFGTFGSFIGFSSWLPPYLVDqF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 237 GMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFITgTPEHMPWFILTLGFFSSAIYTTIIT 316
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 317 LGSQQTKVASPKLVN----FVLTCGTIGTMLTFVVTGPIVAHSGpqaALQTANGLYAVVFVMCFILGFVTRHRQHNAPAT 392
Cdd:COG2223 316 VFALVPDIFPTKNAGavygLVGAAGGLGGFLGPLLFGALLDATG---SYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-381 |
4.55e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 57.44 E-value: 4.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 14 FLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLS 93
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 94 HSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLAR-SIEWYWVYACIGLV 172
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 173 YVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGI--------GVLFLAIAALCYILGQLGFISWVPEYAKSLGM-SLNDA 243
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkrvlknpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 244 GKLVSDFWMSYMVGMWAFSFILRFFdLQRILTVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTIITLGSQQTK 323
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 489113740 324 VASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFILGFV 381
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-381 |
1.18e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 14 FLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLS 93
Cdd:COG2807 24 VLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 94 HSLALFSAAMFVLGLVSGITMSIGTFLVTQMYeGRQRGSRLlftdSFFSMAGMIFPMVAAFL---LARSIEWYWVYACIG 170
Cdd:COG2807 104 PSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMT----GLYTAAMGLGAALAAGLtvpLAAALGWRGALAVWA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 171 LVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGIGVLF-LAIAALCYILGQLGFISWVPEYAKSLGMSLNDAGKLVSD 249
Cdd:COG2807 179 LLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWlLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 250 FWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFITGTPEHMPWF-ILTLGFFSSAIYTTIITLGSQQTKVA--S 326
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLwAVLLGLGQGGLFPLALTLIGLRARTPaeA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489113740 327 PKLVNFVLTCGTIGTMLtfvvtGPIVAhsgpqAALQTANGLYAVVFVMCFILGFV 381
Cdd:COG2807 339 AALSGMAQSVGYLLAAL-----GPLLV-----GALHDATGSWTAALLLLAALAVL 383
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-378 |
1.07e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.26 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 25 IVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMF 104
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 105 VLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIEWYWVYACIGLVYVAIFLLTFgce 184
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWRWAFIIEGLLGLLLAVLWW--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 185 fpalgkhaqqsdapvvkeKWGIGVLFLAIAALCYILGQLGFISWVPEY-AKSLGMSLNDAGKLVSDFWMSYMVGMWAFSF 263
Cdd:cd17319 176 ------------------FYLRQVWGLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 264 IL-RFFDLQRILTVLAG--LATVLMYLFITGTPEHMPWFILTLGFFssAIYTTIITLGSQQTKVASPKLV----NFVLTC 336
Cdd:cd17319 238 LSdRLLRGARRLVIIIGllLAAVGLLLAYLTTSPVVAVILLSLAGF--GIGAASPVFWSLPADLLPGEAAatagGLINSG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489113740 337 GTIGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFIL 378
Cdd:cd17319 316 GNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
58-356 |
6.13e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 47.76 E-value: 6.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 58 ISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFT 137
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFW 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 138 DSFFSMAGMIFPMVAAFLLARSIEWYWVY---ACIGLVyVAIFLLTFGCEFPA---LGK------HAQQSDAPVVKE--- 202
Cdd:TIGR00881 125 NCSHNVGGGLLPPLVLFGIAELYSWHWVFivpGIIAII-VSLICFLLLRDSPQscgLPPaeempnEEPDGDAEKKEEelt 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 203 KWGIGV------LFLAIAALCYILGQL---GFISWVPEYAK-SLGMSLNDAGKLVSDFWMSYMVGMWAFSFIL-RFFDLQ 271
Cdd:TIGR00881 204 KKQIFLqyvllnKVLWYISLGYVFVYVvrtGILDWSPLYLTqEKGFSKEKASWAFTLYELGGLVGTLLAGWLSdKLFNGR 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 272 RILTVLAGLATVLM-----YLFITGTPEHMPWFILTLGFFssaIYTTIITLGSQQTKVASPKLVN----FVLTCGTIGTM 342
Cdd:TIGR00881 284 RGPLAVFFMALIIVsllvyWLNPAANPLMDLICLFALGFL---VYGPQMLIGVIASELAPKKAAGtaagFVGFFAYLGGI 360
|
330
....*....|....
gi 489113740 343 LTFVVTGPIVAHSG 356
Cdd:TIGR00881 361 LAGLPLGYLADGFG 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-379 |
8.03e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 8.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 19 LTGALVIVTGM----VMGNIADYFHLPVSSMSN-TFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLA-VAGLML 92
Cdd:cd17473 6 LASTLTVMAGAaiapALPAIAQHFVPNSELLVPlLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGgVAGLFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 93 ShSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLarSIEW---YWVYACI 169
Cdd:cd17473 86 D-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA--EIGWrapFLVYLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 170 GLVYVAIFLLTF---GCEFPALGKHAQQSDAPVVKEKWGIGVL-FLAIAALCYILGQLGFIswvpeYAKSLGMSLNDAGK 245
Cdd:cd17473 163 LPVLILVLLFLPepaRKSKSAASPGAATAAALPWKRVLPIYFLaFLAMLLFYVIPIQLPFL-----LQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 246 LVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFitGTPEHMPWFILTLGFFSSAIYTTIITLGSQQTKVA 325
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL--ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 489113740 326 SPKLVN----FVLTCGTIGTMLTFVVTGPIV-AHSGPQAALQTANGLYAVVFVMCFILG 379
Cdd:cd17473 316 PPELRGramgIVTSAFFLGQFLSPLVLGPLVnLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
58-356 |
2.24e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 58 ISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFT 137
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIW 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 138 DSFFSMAGMIFPMVAAFLLARsIEWYWVY---ACIGLVyVAIFLLTFgcefpalgkhaqQSDAPvvkekwgIGVLFLAIA 214
Cdd:cd17312 133 STSHNFGGILAPILAASLASY-YGWRAAFlvpGIVGLV-VAIILFFF------------LRDSP-------PYVWVLSLA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 215 ALCYILGQLGFISWVPEY-AKSLGMSLNDAGKLVSDFWMSYMVGMWAFSFIL-RFFDLQRILTVL--AGLATVLMYLFIT 290
Cdd:cd17312 192 YAFVYIVRYACLDWGPLYlYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSdKLFGGRRAPIAViyMLLMTLSLALFWF 271
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489113740 291 gTPEHMPWFILTL---GFFSSAIYTTIITLGSQQ--TKVASPKLVNFVLTCGTIGTMLTFVVTGPIVAHSG 356
Cdd:cd17312 272 -FPHNKLLSIVLLfliGFFVGGPINLIGGAAAQDigRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-290 |
6.22e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.42 E-value: 6.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 1 MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGF 80
Cdd:COG0477 7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 81 ILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGsRLLFTDSFFSMAGMIFPMVAAFLLARSI 160
Cdd:COG0477 87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERG-RALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 161 EWYWVYACIGLVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYAKSLGMSL 240
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489113740 241 NDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFIT 290
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-317 |
6.49e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 9 LTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVA 88
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 89 GLMLSHSLALFSAAMFVLGLVSGITMSIGTFL-VTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArSIEWYWVYA 167
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGTLAAVAFAtVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE-AFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 168 CIGLVY--VAIFLLTFGCEFPALGKHA------QQSDAPVVKEKWGIG---VLFLAIAALCYILGqlGFISWVPEYAKSL 236
Cdd:cd17355 163 VLALLAllVLVPVLLLLRRRPADLALRayddasPASPGSTLKEALRSAsfwLLALAFFLCGFAVV--GLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 237 GMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATV-LMYLFITGTPEHMPW-FILTLGFFSSAIYTTI 314
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALgLALLLLLPFPPLALLlFAALFGLGWGATVPLT 320
|
...
gi 489113740 315 ITL 317
Cdd:cd17355 321 AAL 323
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
54-181 |
1.01e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 54 AGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSR 133
Cdd:cd17474 246 LLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA 325
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 489113740 134 LLFTDSFFSMAGMIFPMVAAFLLARSIeWYWVYACIGLVYVAIFLLTF 181
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
10-378 |
1.54e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.44 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 10 TWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAG 89
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 90 LMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLA-RSIEWYWVYA- 167
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPlLPPEIAWRVLf 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 168 CIGLV--YVAIFLLTFGCEFP--ALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYIL------GQLGFISWVPEYAKS-L 236
Cdd:cd17371 161 LLGALpaLLVLFIRRFVKEPPqwQAARAARRHFADRPSLRELFSPPLLRTTLLASLLatgalgGYYGITTWLPSYLTGeR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 237 GMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTV--LAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTI 314
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALfaLGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGM 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 315 ITLGSQqtkvASPKLV-----NFVLTCGTIGTMLTFVVTGPIVAHSGPQAALQT-ANGLYAVVFVMCFIL 378
Cdd:cd17371 321 GAYLTE----LFPTAVrataqGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVfAAVYYIAGLVLALLL 386
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
33-373 |
1.72e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.40 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 33 NIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGI 112
Cdd:cd17393 24 AIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 113 T---MSIGTFLVTQMYeGRQRGSRLlftDSFFSMAGMIFPMVAAFLLARSIEWYWVYacIGLVYVAIFLLTFGCEF---- 185
Cdd:cd17393 104 LdvaMNAQGVAVERAY-GRPIMSSL---HAMWSLGGLAGALLGAAAIGAGVSPGVHL--LAAAVLLLLAALVAIRAllpg 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 186 -PALGKHAQQSDAPVVKEKWGIGVLFLAIAALCYILGQLGFISWVPEYAKS-LGMSLNDAGKLVSDFWMSYMVGMWAFSF 263
Cdd:cd17393 178 tGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDvLGASAALAALGYAVFSLAMTVGRLFGDR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 264 ILRFFDLQRILTVLAGLAT--VLMYLFITGTPEHMPWFILtLGFFSSAIYTTIITLGSQQTKVASPKLVNFVLTCGTIGT 341
Cdd:cd17393 258 LVDRFGDVAVLRAGALLAAlgLLLALLAPSVWVALAGFAL-MGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGF 336
|
330 340 350
....*....|....*....|....*....|..
gi 489113740 342 MLTFVVTGPIVAHSGPQAALQTANGLYAVVFV 373
Cdd:cd17393 337 LVGPPLIGFLADATGLRTAFLVVALLALLVAL 368
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
54-318 |
2.30e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 54 AGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIgTFLVTQMYEGRQRGSR 133
Cdd:cd17471 44 SGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQ-LFALAREYADRSSGRD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 134 LLFTDS----FFSMAGMIFPMVAAFLLARsIEWYWVYACIGLVYVAIFLLTFGCeFPALGKHAQQSDAPVVKEKWGIG-- 207
Cdd:cd17471 123 ATLFNSvlraAFSLAWVIGPPLAFLLLDV-LGFTGLFLLAALLYLVVALLVLFL-LPSVKPPAQKATPASSLVKAPVNrr 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 208 VLFLAIAALCYILGQLGFISWVPEY-AKSLGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILtVLAGLATVLMY 286
Cdd:cd17471 201 LLLLFAAFTLLFAANSMYIIAMPLYvTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLL-LAGFLAGVLFY 279
|
250 260 270
....*....|....*....|....*....|..
gi 489113740 287 LFITGTPEhmPWFILTLGFFSSAIYTTIITLG 318
Cdd:cd17471 280 LGLALATS--LWQLIALQLLNAIFIGITAGLG 309
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-317 |
4.61e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 34 IADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGIT 113
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 114 MSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFlLARSIEWYWVYACIGLVYVAIFLLTFGcEFPALGKHAQ 193
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL-LGQLLGWRAAFLAIAVLALLAALLLWR-LLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 194 QSDaPVVKEKWGI----GVLFLAIAALCYILGQLGFISWVPEYAKSL-GMSLNDAGKLVSDFWMSYMVGMWAFSFILRFF 268
Cdd:cd17324 183 GSL-GLLSSLLLLlrnpRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489113740 269 DLQRILTVLAGLATVLmyLFITGTPEHMPWFILTLGFFSSAIYTTIITL 317
Cdd:cd17324 262 GRRALLIALLLLAAAL--LLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL 308
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
82-378 |
5.32e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 82 LMVLAVAGLM--LSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLArs 159
Cdd:cd17474 71 LLLFGIGGLLcgLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-- 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 160 IEWYWVY----ACIGLVYVAIFLLTFGCEFPALGKHAQQSDAPVVKEKWGIGVLFlAIAALCYILGQLGFISWVPEYAK- 234
Cdd:cd17474 149 ISWRYPFfllaALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTF-LVSAFLYFFLYFAFLTYLPFLLEl 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 235 SLGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILtVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYTTI 314
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI-LVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNL 306
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489113740 315 ITLGSQQTKVASPKLVNFVLTCGT----IGTMLTFVVTGPIVAHSGPQAALQTANGLYAVVFVMCFIL 378
Cdd:cd17474 307 PLLTTLVTELAPEEERGTASSLYNfvrfLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
11-307 |
7.21e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 7.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 11 WISFLSYALTGALVIVTGMVMgniADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGL 90
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFL---QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 91 MLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGsrllFTDSFFSMAGMIFPMVAAFLL---ARSIEWYWVYA 167
Cdd:cd17475 79 ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERG----LAMGIRQTGVPLGGALAAALLpplALHYGWRAAFV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 168 CIGLVYVAIFLLTF-GCEFPALGKHAQQSDAPVVKEKWGI----GVLFLAIAALCYILGQLGFISWVPEYAKS-LGMSLN 241
Cdd:cd17475 155 VAGLVSILAAVLFWlFYREPPAASAATESASTLLRSLKEVlrnrDVWLIAIAGALLVAPQFALLTFLLLFLHDhLGLSVV 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489113740 242 DAGKLVSDFWMSYMVGMWAFSFIL-RFFDLQR-----ILTVLAGLATVLMYLFITGTPehmPWFILTLGFFS 307
Cdd:cd17475 235 AAGALLAVAQLGGALGRIGLGRVSdRVFGGRRrpvlvITAAIAAAALLVLSLLSPGTP---LWLLVLLLILL 303
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
233-317 |
7.83e-04 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 41.03 E-value: 7.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 233 AKSLGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFDLQRILTVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAIYT 312
Cdd:TIGR01272 170 PHALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTHGYVAMWFVLALGLFNSIMFP 249
|
....*
gi 489113740 313 TIITL 317
Cdd:TIGR01272 250 TIFSL 254
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-145 |
1.26e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 9 LTWISFLSYALTGALVIVTGMVMGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVA 88
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 489113740 89 GLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAG 145
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
6-181 |
1.30e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 6 RIKLTWISFLSYALTGALVIVTGMVMGNIA-DYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMV 84
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 85 LAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLVTQMYEGRQRGsRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYW 164
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRG-RVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*..
gi 489113740 165 VYACIGLVYVAIFLLTF 181
Cdd:cd06173 365 VFLLAGALLLLAALLLL 381
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-310 |
1.97e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 31 MGNIADYFHLPVSSMSNTFTFLNAGILISIFLNAWLMEIVPLKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVS 110
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 111 GITMSIGTFLVTQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSiEWYWVYACIGLVYVAIFLLTFGCEFPALGK 190
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWRAIFVFLALLGLLLLLLVLLFLPETLPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 191 HAQQSDAPVVKEKWGI-----GVLFLAIAALCYILGQLGFISWVPE-YAKSLGMSLNDAGKLVSDFWMSYMVGMWAFSFI 264
Cdd:cd17320 181 EKRKPLLSSLLRAYKRvlknrRFLGYALALGLSFAGLFAYLAAAPFiYIEQLGLSPAQFGLLFALNAIALILGSLLNGRL 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489113740 265 LRFFDLQRIL---TVLAGLATVLMYLFITGTPEHMPWFILTLGFFSSAI 310
Cdd:cd17320 261 VRRFGPRRLLrlgLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
54-382 |
2.87e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 54 AGILISIFLNAWLMEivplKTQLRFGFILMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSiGTFLVTQ-----MYEGR 128
Cdd:cd17477 42 LGILLGSPLVPRLIR----RVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLA-GLFVVSEswlnaLATNE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 129 QRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYACIGLVYVAIFLLTFGCEfPALGKHAQQSDAPVVKEKWGIgv 208
Cdd:cd17477 117 NRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAA-PEIEEAESISLRRLLRIAPLA-- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 209 lflAIAALCYILGQLGFISWVPEYAKSLGMSLNDAGKLVSDFWMSYMVGMWAFSFILRFFD---LQRILTVLAGLATVLM 285
Cdd:cd17477 194 ---LLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDrrrVLLGCALLGALAALLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489113740 286 YLFITGTPEHMPWFILtLGFFSSAIYTTIITLGSQqtKVASPKLVN---FVLTCGTIGTMLTFVVTGPIVAHSGPQaalq 362
Cdd:cd17477 271 PLVPGLPLALLVLLFL-WGGAAGPLYTLALALAGD--RLPGDELVAanaALLLLYGLGSVIGPLLAGALMDAFGPH---- 343
|
330 340
....*....|....*....|
gi 489113740 363 tanGLYAVVFVMCFILGFVT 382
Cdd:cd17477 344 ---GLFLFLAAVALLFLLFL 360
|
|
| |
