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Conserved domains on  [gi|489113666|ref|WP_003023519|]
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MULTISPECIES: ferrous iron transporter A [Enterobacteriaceae]

Protein Classification

ferrous iron transporter A( domain architecture ID 10013270)

ferrous iron transporter A is involved in Fe(2+) ion uptake

Gene Ontology:  GO:0034755

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
feoA PRK09555
ferrous iron transporter A;
1-74 8.91e-49

ferrous iron transporter A;


:

Pssm-ID: 181949  Cd Length: 74  Bit Score: 147.98  E-value: 8.91e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489113666  1 MQFTPDSAWKITGFAREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVEAVS 74
Cdd:PRK09555  1 MQLTPDTAYKITGFSREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELEAVS 74
 
Name Accession Description Interval E-value
feoA PRK09555
ferrous iron transporter A;
1-74 8.91e-49

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 147.98  E-value: 8.91e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489113666  1 MQFTPDSAWKITGFAREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVEAVS 74
Cdd:PRK09555  1 MQLTPDTAYKITGFSREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELEAVS 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
10-71 2.99e-15

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 63.23  E-value: 2.99e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489113666 10 KITGFarEISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVE 71
Cdd:COG1918  13 RIVRI--SGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 19-71 3.64e-11

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 52.98  E-value: 3.64e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489113666  19 SPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVE 71
Cdd:pfam04023 21 DPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 19-71 1.95e-07

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 43.33  E-value: 1.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489113666   19 SPAYRQKLLSLGMLPGSSFNVVRVAPLGdPIHIETRRvSLVLRKKDLALLEVE 71
Cdd:smart00899 21 DPELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVE 71
 
Name Accession Description Interval E-value
feoA PRK09555
ferrous iron transporter A;
1-74 8.91e-49

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 147.98  E-value: 8.91e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489113666  1 MQFTPDSAWKITGFAREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVEAVS 74
Cdd:PRK09555  1 MQLTPDTAYKITGFSREISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELEAVS 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
10-71 2.99e-15

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 63.23  E-value: 2.99e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489113666 10 KITGFarEISPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVE 71
Cdd:COG1918  13 RIVRI--SGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 19-71 3.64e-11

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 52.98  E-value: 3.64e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489113666  19 SPAYRQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLEVE 71
Cdd:pfam04023 21 DPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 19-71 1.95e-07

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 43.33  E-value: 1.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489113666   19 SPAYRQKLLSLGMLPGSSFNVVRVAPLGdPIHIETRRvSLVLRKKDLALLEVE 71
Cdd:smart00899 21 DPELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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