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Conserved domains on  [gi|489112944|ref|WP_003022798|]
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LysE/ArgO family amino acid transporter [Francisella tularensis]

Protein Classification

LysE/ArgO family amino acid transporter( domain architecture ID 10003422)

amino acid transporter belonging to the LysE/ArgO transporter family such as Corynebacterium lysine exporter protein (LysE), which is involved in the efflux of excess L-lysine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgO COG1279
Arginine exporter protein ArgO [Amino acid transport and metabolism];
1-202 2.92e-53

Arginine exporter protein ArgO [Amino acid transport and metabolism];


:

Pssm-ID: 440890  Cd Length: 204  Bit Score: 169.20  E-value: 2.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   1 MAFISGFSLALSLILGIGAQNIFVLKQAIKMNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVY 80
Cdd:COG1279    3 SAFLQGFLLGLSLIVAIGAQNAFVLRQGLRREHVLPVALICALSDALLIALGVFGVGALLAASPWLLTVLRWGGAAFLLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  81 YGIFSIKSSFTENKILD-ESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYSENiLKIEFMLGAGVASLVWFV 159
Cdd:COG1279   83 YGLRALRRALRGGAALDaAEGAALSLRKAILTALAVTLLNPHVYLDTVVLLGSIAAQYGGD-ERWAFALGAILASFLWFF 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 489112944 160 SLMLSGLFLRKFIQKIIVWQWIERLTGVLMFVIAINCIRLLIN 202
Cdd:COG1279  162 GLGYGARLLAPLFARPRAWRVLDLLIGLVMWAIALKLLLGLLA 204
 
Name Accession Description Interval E-value
ArgO COG1279
Arginine exporter protein ArgO [Amino acid transport and metabolism];
1-202 2.92e-53

Arginine exporter protein ArgO [Amino acid transport and metabolism];


Pssm-ID: 440890  Cd Length: 204  Bit Score: 169.20  E-value: 2.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   1 MAFISGFSLALSLILGIGAQNIFVLKQAIKMNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVY 80
Cdd:COG1279    3 SAFLQGFLLGLSLIVAIGAQNAFVLRQGLRREHVLPVALICALSDALLIALGVFGVGALLAASPWLLTVLRWGGAAFLLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  81 YGIFSIKSSFTENKILD-ESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYSENiLKIEFMLGAGVASLVWFV 159
Cdd:COG1279   83 YGLRALRRALRGGAALDaAEGAALSLRKAILTALAVTLLNPHVYLDTVVLLGSIAAQYGGD-ERWAFALGAILASFLWFF 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 489112944 160 SLMLSGLFLRKFIQKIIVWQWIERLTGVLMFVIAINCIRLLIN 202
Cdd:COG1279  162 GLGYGARLLAPLFARPRAWRVLDLLIGLVMWAIALKLLLGLLA 204
PRK09304 PRK09304
arginine exporter ArgO;
3-193 3.70e-15

arginine exporter ArgO;


Pssm-ID: 236463  Cd Length: 207  Bit Score: 70.53  E-value: 3.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   3 FISGFSLALSLILGIGAQNIFVLKQAIKMNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVYYG 82
Cdd:PRK09304   5 YFQGFALGAAMILPLGPQNAFVMNQGIRRQYHLMIALLCALSDLVLICAGIFGGSALLMQSPWLLALVTWGGVAFLLWYG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  83 IFSIKSSFTENKILDES-FHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYSEnILKIEFMLGAGVASLVWFVSL 161
Cdd:PRK09304  85 FGAFKTAMSSNIELASAeVMKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLDV-EPKRWFALGTISASFLWFFGL 163

                        170       180       190
                 ....*....|....*....|....*....|..
gi 489112944 162 MLSGLFLRKFIQKIIVWQWIERLTGVLMFVIA 193
Cdd:PRK09304 164 ALLAAWLAPRLRTAKAQRIINLFVGCVMWFIA 195
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
 11-198 1.51e-10

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 57.69  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   11 LSLILGIGAQNIFVLKQAIK--MNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVYYGIFSIKS 88
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISrgFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   89 SFtENKILDESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYS--ENILKIEFMLGAGVASLVWFVSLMLSGL 166
Cdd:pfam01810  81 AK-SPKNESLSSSEASLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKNQqyGDAGRLIFAAGIVVASLIWFSLLAFLAS 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 489112944  167 FLRKFIQKIIVWQWIERLTGVLMFVIAINCIR 198
Cdd:pfam01810 160 RLARRLSTPKVRRIINVIAGALFIGFGVFLLY 191
 
Name Accession Description Interval E-value
ArgO COG1279
Arginine exporter protein ArgO [Amino acid transport and metabolism];
1-202 2.92e-53

Arginine exporter protein ArgO [Amino acid transport and metabolism];


Pssm-ID: 440890  Cd Length: 204  Bit Score: 169.20  E-value: 2.92e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   1 MAFISGFSLALSLILGIGAQNIFVLKQAIKMNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVY 80
Cdd:COG1279    3 SAFLQGFLLGLSLIVAIGAQNAFVLRQGLRREHVLPVALICALSDALLIALGVFGVGALLAASPWLLTVLRWGGAAFLLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  81 YGIFSIKSSFTENKILD-ESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYSENiLKIEFMLGAGVASLVWFV 159
Cdd:COG1279   83 YGLRALRRALRGGAALDaAEGAALSLRKAILTALAVTLLNPHVYLDTVVLLGSIAAQYGGD-ERWAFALGAILASFLWFF 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 489112944 160 SLMLSGLFLRKFIQKIIVWQWIERLTGVLMFVIAINCIRLLIN 202
Cdd:COG1279  162 GLGYGARLLAPLFARPRAWRVLDLLIGLVMWAIALKLLLGLLA 204
PRK09304 PRK09304
arginine exporter ArgO;
3-193 3.70e-15

arginine exporter ArgO;


Pssm-ID: 236463  Cd Length: 207  Bit Score: 70.53  E-value: 3.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   3 FISGFSLALSLILGIGAQNIFVLKQAIKMNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVYYG 82
Cdd:PRK09304   5 YFQGFALGAAMILPLGPQNAFVMNQGIRRQYHLMIALLCALSDLVLICAGIFGGSALLMQSPWLLALVTWGGVAFLLWYG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  83 IFSIKSSFTENKILDES-FHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYSEnILKIEFMLGAGVASLVWFVSL 161
Cdd:PRK09304  85 FGAFKTAMSSNIELASAeVMKQGRWKIIATMLAVTWLNPHVYLDTFVVLGSLGGQLDV-EPKRWFALGTISASFLWFFGL 163

                        170       180       190
                 ....*....|....*....|....*....|..
gi 489112944 162 MLSGLFLRKFIQKIIVWQWIERLTGVLMFVIA 193
Cdd:PRK09304 164 ALLAAWLAPRLRTAKAQRIINLFVGCVMWFIA 195
LysE pfam01810
LysE type translocator; This family consists of various hypothetical proteins and an l-lysine ...
 11-198 1.51e-10

LysE type translocator; This family consists of various hypothetical proteins and an l-lysine exporter LysE from Corynebacterium glutamicum which is proposed to be the first of a novel family of translocators. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine.


Pssm-ID: 280058  Cd Length: 193  Bit Score: 57.69  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   11 LSLILGIGAQNIFVLKQAIK--MNYAISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLVYYGIFSIKS 88
Cdd:pfam01810   1 LSLALAPGPVNAFVLRQSISrgFKGGILVALGVVIGDAVLILLGLLGLATLLTASPILFSVLRLAGGAYLLWLGILMLRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   89 SFtENKILDESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGGVATTYS--ENILKIEFMLGAGVASLVWFVSLMLSGL 166
Cdd:pfam01810  81 AK-SPKNESLSSSEASLRKSFLRGLLVSLSNPKAILFWLSVFSAFLGKNQqyGDAGRLIFAAGIVVASLIWFSLLAFLAS 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 489112944  167 FLRKFIQKIIVWQWIERLTGVLMFVIAINCIR 198
Cdd:pfam01810 160 RLARRLSTPKVRRIINVIAGALFIGFGVFLLY 191
RhtB COG1280
Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];
2-194 1.91e-07

Threonine/homoserine/homoserine lactone efflux protein [Amino acid transport and metabolism];


Pssm-ID: 440891  Cd Length: 205  Bit Score: 49.45  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944   2 AFISGFSLALSLILGIGAQNIFVLKQAIKMNY--AISTAVICFFCDVILIFFSVVLTTTMVRYLAVVRPIMLIFAVLFLV 79
Cdd:COG1280    5 LLLAFLLAALVLALTPGPDNLLVLSRGLRRGRraGLAAALGIALGDLVHILLAALGLAALLAASPLLFTVLKLAGAAYLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489112944  80 YYGIFSIKSSFTenKILDESFHQQNFFKVLILSMSFSLLNPQAILDIVVLLGG-VATTYSENILKIEFMLGAGVASLVWF 158
Cdd:COG1280   85 YLGWKLLRSAGR--PLAAEAAAAASARRLFRQGFLLNLLNPKAILFFLAFLPQfVDPGAPLLLQLLLLGATFLLVSLLWL 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 489112944 159 VSLMLSGLFLRKFIQKIIVWQWIERLTGVLMFVIAI 194
Cdd:COG1280  163 LLYALLASRLRRRLRSPRALRWLNRVAGLLLIGFGL 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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