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Conserved domains on  [gi|489081000|ref|WP_002990934|]
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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase [Streptococcus pyogenes]

Protein Classification

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase( domain architecture ID 11487059)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


:

Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 932.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   2 ITIEQLLDILKKDHNFREVLDADGYHYHYQGLSFERLSYDSRQVDGKTLFFAKGATFKADYLKEAITNGLQLYISEVDYE 81
Cdd:PRK14022   1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  82 LGIPVVLVTDIKKAMSLIAMAFYGNPQEKLKLLAFTGTKGKTTAAYFAYHMLKESYKPAMFSTMNTTLDGKTFFKSQLTT 161
Cdd:PRK14022  81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 162 PESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLMENSRAVVI 241
Cdd:PRK14022 161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 242 NSGMDHFSFLADQVADQEHVFYGPLSDNQITTSQAFSFEAKGQLAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQK 321
Cdd:PRK14022 241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 322 GIAKTRVPGRMEVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLTVIL 401
Cdd:PRK14022 321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 402 TADDPNFEDPEDISKEIASHIARPVEIISDREQAIQKAMSLCQGAKDAVIIAGKGADAYQIVKGQQVAYAGDLAIAKHYL 481
Cdd:PRK14022 401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
 
Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 932.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   2 ITIEQLLDILKKDHNFREVLDADGYHYHYQGLSFERLSYDSRQVDGKTLFFAKGATFKADYLKEAITNGLQLYISEVDYE 81
Cdd:PRK14022   1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  82 LGIPVVLVTDIKKAMSLIAMAFYGNPQEKLKLLAFTGTKGKTTAAYFAYHMLKESYKPAMFSTMNTTLDGKTFFKSQLTT 161
Cdd:PRK14022  81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 162 PESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLMENSRAVVI 241
Cdd:PRK14022 161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 242 NSGMDHFSFLADQVADQEHVFYGPLSDNQITTSQAFSFEAKGQLAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQK 321
Cdd:PRK14022 241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 322 GIAKTRVPGRMEVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLTVIL 401
Cdd:PRK14022 321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 402 TADDPNFEDPEDISKEIASHIARPVEIISDREQAIQKAMSLCQGAKDAVIIAGKGADAYQIVKGQQVAYAGDLAIAKHYL 481
Cdd:PRK14022 401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 38-481 5.96e-145

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 422.57  E-value: 5.96e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  38 LSYDSRQVDGKTLFFA-KGATFK-ADYLKEAITNGLQLYISEVDYEL---GIPVVLVTDIKKAMSLIAMAFYGNPQEKLK 112
Cdd:COG0769    2 ITYDSRKVKPGDLFVAlPGARVDgHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 113 LLAFTGTKGKTTAAYFAYHMLKES-YKPAMFSTMNTTLDGKTFfKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQAY 191
Cdd:COG0769   82 LIGVTGTNGKTTTTYLLAQILRALgKKTGLIGTVGNGIGGELI-PSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 192 LVDRVYGLTFDVGVFLNISPDHIgpIEHPTFEDYFYHKRLLMEN---SRAVVINSGMDHFSFLADQvADQEHVFYGPLSD 268
Cdd:COG0769  161 DQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLAAA-APARVITYGLKAD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 269 NQIT--------TSQAFSFEAKGQlAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAK-TRVPGRMEVLTMTN 339
Cdd:COG0769  238 ADLRatdielsaDGTRFTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGGQ 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 340 HAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPNFEDPEDISKEIA 419
Cdd:COG0769  317 GPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADV-VIVTSDNPRSEDPAAIIADIL 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489081000 420 SHI--ARPVEIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAYAgDLAIAKHYL 481
Cdd:COG0769  396 AGIpgAGKVLVIPDRAEAIRYAIALAK-PGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 38-470 1.30e-92

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 288.83  E-value: 1.30e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   38 LSYDSRQVDGKTLFFA-KGATFK-ADYLKEAITNGLQLYISEVDYEL---GIPVVLVTDIKKAMSLIAMAFYGNPQEKLK 112
Cdd:TIGR01085   7 LTLDSREVKPGDLFVAiKGTHVDgHDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFYGHPSKKLK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  113 LLAFTGTKGKTTAAYFAYHMLKES-YKPAMFSTMNTTLDG--KTFFKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQ 189
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLgKKTGLIGTIGYRLGGndLIKNPAALTTPEALTLQSTLAEMVEAGAQYAVMEVSSH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  190 AYLVDRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLME----NSRAVVIN-----------SGMDHFSFLADQ 254
Cdd:TIGR01085 167 ALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLFTelglKRFAVINLddeygaqfvkrLPKDITVSAITQ 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  255 VADQEHVFYGPLSDNQITTSQAFSFEAKGQLaGHYDIQLIGHFNQENAMAAGLACLRLG-ASLADIQKGIAKTR-VPGRM 332
Cdd:TIGR01085 245 PADGRAQDIKITDSGYSFEGQQFTFETPAGE-GHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRgVPGRM 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  333 EVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPNFEDPE 412
Cdd:TIGR01085 324 ELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-VILTSDNPRGEDPE 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  413 DISKEIASHI--ARPVEIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAY 470
Cdd:TIGR01085 403 QIIADILAGIseKEKVVIIADRRQAIRYAISNAK-AGDVVLIAGKGHEDYQIIGGETIPF 461
Mur_ligase_M pfam08245
Mur ligase middle domain;
117-309 1.54e-35

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 130.89  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  117 TGTKGKTTAAYFAYHMLKESYKpaMFSTMnttldGKTFFKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRV 196
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGG--VIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  197 YGLT-FDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMENSRA---VVINSGMDHFSFLAD--QVADQEHVFYGPLSDNQ 270
Cdd:pfam08245  75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPEdgiAVINADDPYGAFLIAklKKAGVRVITYGIEGEAD 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 489081000  271 ITTS--QAFSFEAKGQLAGH------YDIQLIGHFNQENAMAAGLAC 309
Cdd:pfam08245 153 LRAAniELSSDGTSFDLFTVpggeleIEIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 932.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   2 ITIEQLLDILKKDHNFREVLDADGYHYHYQGLSFERLSYDSRQVDGKTLFFAKGATFKADYLKEAITNGLQLYISEVDYE 81
Cdd:PRK14022   1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  82 LGIPVVLVTDIKKAMSLIAMAFYGNPQEKLKLLAFTGTKGKTTAAYFAYHMLKESYKPAMFSTMNTTLDGKTFFKSQLTT 161
Cdd:PRK14022  81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 162 PESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLMENSRAVVI 241
Cdd:PRK14022 161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 242 NSGMDHFSFLADQVADQEHVFYGPLSDNQITTSQAFSFEAKGQLAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQK 321
Cdd:PRK14022 241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 322 GIAKTRVPGRMEVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLTVIL 401
Cdd:PRK14022 321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 402 TADDPNFEDPEDISKEIASHIARPVEIISDREQAIQKAMSLCQGAKDAVIIAGKGADAYQIVKGQQVAYAGDLAIAKHYL 481
Cdd:PRK14022 401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 12-481 1.43e-153

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 444.57  E-value: 1.43e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  12 KKDHNFREVLdadgyhyhyQGLSFERLSYDSRQVDGKTLFFAKGATFK--ADYLKEAITNGLQLYISEVDYE--LGIPVV 87
Cdd:PRK00139   1 MASMKLRDLL---------APVEITGLTYDSRKVKPGDLFVALPGHKVdgRDFIAQAIANGAAAVVAEADGEagTGVPVI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  88 LVTDIKKAMSLIAMAFYGNPQEKLKLLAFTGTKGKTTAAYFAYHMLKE-SYKPAMFSTMNTTLDGKTFfKSQLTTPESLD 166
Cdd:PRK00139  72 IVPDLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILRLlGEKTALIGTLGNGIGGELI-PSGLTTPDALD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 167 LFAMMAECVTNGMTHLIMEVSSQAYLVDRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMEN-SRAVVINSGM 245
Cdd:PRK00139 151 LQRLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLD--YHGTMEDYLAAKARLFSElGLAAVINADD 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 246 DHFSFLADQVAdqehvFYGPLSDNQITTSQAFSFEAKGQ---LAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKG 322
Cdd:PRK00139 229 EVGRRLLALPD-----AYAVSMAGADLRATDVEYTDSGQtftLVTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 323 IAK-TRVPGRMEVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVIL 401
Cdd:PRK00139 304 LAKlQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADV-VIV 382

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 402 TADDPNFEDPEDISKEIASHIARpveIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAYaGDLAIAKHYL 481
Cdd:PRK00139 383 TSDNPRSEDPAAIIADILAGIYD---VIEDRAEAIRYAIAQAK-PGDVVLIAGKGHEDYQIIGGVKIPF-DDREVAREAL 457
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 38-481 5.96e-145

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 422.57  E-value: 5.96e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  38 LSYDSRQVDGKTLFFA-KGATFK-ADYLKEAITNGLQLYISEVDYEL---GIPVVLVTDIKKAMSLIAMAFYGNPQEKLK 112
Cdd:COG0769    2 ITYDSRKVKPGDLFVAlPGARVDgHDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 113 LLAFTGTKGKTTAAYFAYHMLKES-YKPAMFSTMNTTLDGKTFfKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQAY 191
Cdd:COG0769   82 LIGVTGTNGKTTTTYLLAQILRALgKKTGLIGTVGNGIGGELI-PSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 192 LVDRVYGLTFDVGVFLNISPDHIgpIEHPTFEDYFYHKRLLMEN---SRAVVINSGMDHFSFLADQvADQEHVFYGPLSD 268
Cdd:COG0769  161 DQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLAAA-APARVITYGLKAD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 269 NQIT--------TSQAFSFEAKGQlAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAK-TRVPGRMEVLTMTN 339
Cdd:COG0769  238 ADLRatdielsaDGTRFTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGGQ 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 340 HAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPNFEDPEDISKEIA 419
Cdd:COG0769  317 GPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADV-VIVTSDNPRSEDPAAIIADIL 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489081000 420 SHI--ARPVEIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAYAgDLAIAKHYL 481
Cdd:COG0769  396 AGIpgAGKVLVIPDRAEAIRYAIALAK-PGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 38-470 1.30e-92

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 288.83  E-value: 1.30e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   38 LSYDSRQVDGKTLFFA-KGATFK-ADYLKEAITNGLQLYISEVDYEL---GIPVVLVTDIKKAMSLIAMAFYGNPQEKLK 112
Cdd:TIGR01085   7 LTLDSREVKPGDLFVAiKGTHVDgHDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFYGHPSKKLK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  113 LLAFTGTKGKTTAAYFAYHMLKES-YKPAMFSTMNTTLDG--KTFFKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQ 189
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLgKKTGLIGTIGYRLGGndLIKNPAALTTPEALTLQSTLAEMVEAGAQYAVMEVSSH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  190 AYLVDRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLME----NSRAVVIN-----------SGMDHFSFLADQ 254
Cdd:TIGR01085 167 ALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLFTelglKRFAVINLddeygaqfvkrLPKDITVSAITQ 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  255 VADQEHVFYGPLSDNQITTSQAFSFEAKGQLaGHYDIQLIGHFNQENAMAAGLACLRLG-ASLADIQKGIAKTR-VPGRM 332
Cdd:TIGR01085 245 PADGRAQDIKITDSGYSFEGQQFTFETPAGE-GHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKFRgVPGRM 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  333 EVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPNFEDPE 412
Cdd:TIGR01085 324 ELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-VILTSDNPRGEDPE 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  413 DISKEIASHI--ARPVEIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAY 470
Cdd:TIGR01085 403 QIIADILAGIseKEKVVIIADRRQAIRYAISNAK-AGDVVLIAGKGHEDYQIIGGETIPF 461
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 38-478 1.04e-71

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 244.61  E-value: 1.04e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  38 LSYDSRQVDGKTLFFA-KGAtfKAD---YLKEAITNGLQLYISE---VDYELGIP--VVLVTDIKKAMSLIAMAFYGNPQ 108
Cdd:PRK11929  32 LRLDSREVQPGDLFVAcRGA--ASDgraFIDQALARGAAAVLVEaegEDQVAAADalVLPVADLRKALGELAARWYGRPS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 109 EKLKLLAFTGTKGKTTAAYFAYHMLKESYKPA-MFSTMNTTLDGKTFfKSQLTTPESLDLFAMMAECVTNGMTHLIMEVS 187
Cdd:PRK11929 110 EQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCgSIGTLGARLDGRLI-PGSLTTPDAIILHRILARMRAAGADAVAMEAS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 188 SQAYLVDRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMEN---SRAVVINSGMDHFSFLADQVADQEHVFYG 264
Cdd:PRK11929 189 SHGLEQGRLDGLRIAVAGFTNLTRDHLD--YHGTMQDYEEAKAALFSKlpgLGAAVINADDPAAARLLAALPRGLKVGYS 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 265 PL---SD------NQITTSQAFSFEAKGQLAgHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAKTR-VPGRMEV 334
Cdd:PRK11929 267 PQnagADvqardlRATAHGQVFTLATPDGSY-QLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSpVPGRMER 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 335 LTMT---NHAKVFVDYAHNGDSLEKLLSV---VEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPNF 408
Cdd:PRK11929 346 VGPTagaQGPLVVVDYAHTPDALAKALTAlrpVAQARNGRLVCVFGCGGDRDKGKRPEMGRIAAELADR-VVVTSDNPRS 424

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489081000 409 EDPEDISKEIASHIARP--VEIISDREQAIQKAMSLCQgAKDAVIIAGKGADAYQIVKGQQVAYAGDLAIAK 478
Cdd:PRK11929 425 EAPEAIIDQILAGIPAGarVFVISDRAEAIRQAIWMAA-PGDVILIAGKGHETYQEIGGRKLFFDDREWARR 495
Mur_ligase_M pfam08245
Mur ligase middle domain;
117-309 1.54e-35

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 130.89  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  117 TGTKGKTTAAYFAYHMLKESYKpaMFSTMnttldGKTFFKSQLTTPESLDLFAMMAECVTNGMTHLIMEVSSQAYLVDRV 196
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGG--VIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  197 YGLT-FDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMENSRA---VVINSGMDHFSFLAD--QVADQEHVFYGPLSDNQ 270
Cdd:pfam08245  75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPEdgiAVINADDPYGAFLIAklKKAGVRVITYGIEGEAD 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 489081000  271 ITTS--QAFSFEAKGQLAGH------YDIQLIGHFNQENAMAAGLAC 309
Cdd:pfam08245 153 LRAAniELSSDGTSFDLFTVpggeleIEIPLLGRHNVYNALAAIAAA 199
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 41-381 3.79e-22

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 98.49  E-value: 3.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   41 DSRQVDGKTLFFA-KGATFKA-DYLKEAITNGLQLYI--SEVDYELGIPVVLVTDIKKAMSLIAmAFYGNpQEKLKLLAF 116
Cdd:TIGR01143   2 DSRAIKPGDLFIAlKGERFDGhDFVEQALAAGAVAVVvdREVGPDNGLPQILVDDTLEALQALA-RAKRA-KFSGKVIGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  117 TGTKGKTTAAYFAYHMLKESYKPamFSTMNTtldgktfFKSQLTTPESLdlfAMMAEcvtnGMTHLIME--VSSQ---AY 191
Cdd:TIGR01143  80 TGSSGKTTTKEMLAAILSHKYKV--FATPGN-------FNNEIGLPLTL---LRAPG----DHDYAVLEmgASHPgeiAY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  192 LVDRVyglTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMENSRA---VVINSGMDHFSFLADQVADQEHVFYGpLSD 268
Cdd:TIGR01143 144 LAEIA---KPDIAVITNIGPAHLE--GFGSLEGIAEAKGEILQGLKEngiAVINADDPAFADLAKRLPNRNILSFG-FEG 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  269 NQITT---------SQAFSFEAKGQLAGhYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAKTR-VPGRMEVLTMT 338
Cdd:TIGR01143 218 GDFVAkdisysalgSTSFTLVAPGGEFE-VSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKlVKGRFEVQTKN 296

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 489081000  339 NhaKVFVDYAHNG--DSLEKLLSVVeEHQTGKLMLILGAPGNKGE 381
Cdd:TIGR01143 297 G--LTLIDDTYNAnpDSMRAALDAL-ARFPGKKILVLGDMAELGE 338
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 1-374 2.93e-21

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 95.94  E-value: 2.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   1 MITIEQLLDILkkdhnfrevldaDGYHYHYQGLSFERLSYDSRQVDGKTLFFA-KGATFKA-DYLKEAITNGLQLYISEV 78
Cdd:COG0770    2 LLTLAEIAEAT------------GGRLIGDPDLVVTGVSTDSRKIKPGDLFVAlKGERFDGhDFVAQALAKGAAAALVSR 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  79 DYELGIPVVLVTDIKKAMSLIAmAFYGNpQEKLKLLAFTGTKGKTTAAYFAYHMLKESYKpamfstmntTLdgKTF--FK 156
Cdd:COG0770   70 PLPADLPLIVVDDTLKALQQLA-AAHRA-RFNIPVIAITGSNGKTTTKEMLAAVLSTKGK---------VL--ATPgnFN 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 157 SQLTTPesLDLFAMMAEcvTN------GMTHL--ImevssqAYLVDrvygLTF-DVGVFLNISPDHIGpiEHPTFEDYFY 227
Cdd:COG0770  137 NEIGVP--LTLLRLPED--HEfavlemGMNHPgeI------AYLAR----IARpDIAVITNIGPAHLE--GFGSLEGIAR 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 228 HKRLLMENSRA---VVINSGMDHFSFLADQvADQEHVFYGPLSDNQIT------TSQAFSFEAKGQLAGH-YDIQLIGHF 297
Cdd:COG0770  201 AKGEIFEGLPPggvAVLNADDPLLAALAER-AKARVLTFGLSEDADVRaedielDEDGTRFTLHTPGGELeVTLPLPGRH 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 298 NQENAMAAGLACLRLGASLADIQKGIAK-TRVPGRMEVLTMTNHAKVFVDyAHNG--DSLEKLLSVVEE-HQTGKLMLIL 373
Cdd:COG0770  280 NVSNALAAAAVALALGLDLEEIAAGLAAfQPVKGRLEVIEGAGGVTLIDD-SYNAnpDSMKAALDVLAQlPGGGRRIAVL 358


                 .
gi 489081000 374 G 374
Cdd:COG0770  359 G 359
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 83-444 4.85e-20

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 92.02  E-value: 4.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   83 GIPVVlvTDIkkamSLIAMAFygnpqeKLKLLAFTGTKGKTTAAYFAYHMLKESYKPAmFSTMNttldgktffksqLTTP 162
Cdd:TIGR01087  86 GIPVV--GDI----ELFLRLV------PLPVVAITGTNGKTTTTSLLYHLLKAAGLKA-FLGGN------------IGTP 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  163 eSLDLFAmmaecvTNGMTHLIMEVSSqaYLVDRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHK-RLL--MENSRAV 239
Cdd:TIGR01087 141 -ALEVLD------QEGAELYVLELSS--FQLETTESLRPEIALILNISEDHLD--WHGSFEDYVAAKlKIFarQTEGDVA 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  240 VINSGMDHFSFLAdQVADQEHVFYGPLSDnqitTSQAFSFEAKGQL--AGHYDIQLIGHFNQENAMAAGLACLRLGASLA 317
Cdd:TIGR01087 210 VLNADDPRFARLA-QKSKAQVIWFSVEKD----AERGLCIRDGGLYlkPNDLEGSLLGLHNAENILAAIALAKSLGLNLE 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  318 DIQKGIAK-TRVPGRMEVLTmTNHAKVFVD--YAHNGDSLEKLLSVVEEhqtgKLMLILGapgnkGESRRADFGRVIHQH 394
Cdd:TIGR01087 285 AILEALRSfKGLPHRLEYVG-QKNGVHFYNdsKATNVHATLAALSAFDN----PVILIVG-----GDDKGADFSPLAPAA 354

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489081000  395 PNLTVILTA---DDPNFEDpediskeIASHIARPVEIISDREQAIQKAMSLCQ 444
Cdd:TIGR01087 355 AGKVKAVLAigeDAAKIAP-------LLKEAGLSVYLVESLEEAVQAAREVAS 400
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 112-442 1.79e-19

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 90.53  E-value: 1.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 112 KLLAFTGTKGKTTAAYFAYHMLKESYK----------PAMfstmnttldgktffkSQLTTPESLDLfammaecvtngmth 181
Cdd:COG0771  106 PIIAITGTNGKTTTTTLIGHILKAAGLrvavggnigtPLL---------------DLLLEPEPPDV-------------- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 182 LIMEVSS-QAylvDRVYGLTFDVGVFLNISPDHIgpiE-HPTFEDYFYHKRLLMENSRA---VVIN------------SG 244
Cdd:COG0771  157 YVLELSSfQL---ETTPSLRPDVAVILNITPDHL---DrHGSMEAYAAAKARIFANQTPddyAVLNaddpltralaeeAK 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 245 MDHFSFLADQVADQEhvFYgpLSDNQIT--TSQAFSFEAKgqlaghyDIQLIGHFNQENAMAAGLACLRLGASLADIQKG 322
Cdd:COG0771  231 ARVVPFSLKEPLEGG--AG--LEDGKLVdrASGEELLPVD-------DLRLPGRHNLENALAALAAARALGVPPEAIREA 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 323 IAKTR-VPGRMEVLTMTNHakvfVDY-----AHNGDSLEK-LLSVveehqTGKLMLILGapgnkGESRRADF-------- 387
Cdd:COG0771  300 LRSFKgLPHRLEFVAEING----VRFindskATNPDATLAaLESF-----DGPVVLIAG-----GLDKGADFsplapava 365

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489081000 388 GRVIHqhpnltVILtaddpnF-EDPEDISKEIASHIArPVEIISDREQAIQKAMSL 442
Cdd:COG0771  366 ERVKA------VVL------IgEDAEKIAAALAGAGV-PVVIVETMEEAVAAAAEL 408
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 328-414 5.28e-19

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 81.62  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  328 VPGRMEVLTMTNHAKVFVDYAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGESRRADFGRVIHQHPNLtVILTADDPN 407
Cdd:pfam02875   1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADV-VILTGDYPR 79


                  ....*..
gi 489081000  408 FEDPEDI 414
Cdd:pfam02875  80 AEDPGAI 86
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 36-393 1.90e-14

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 75.90  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  36 ERLSYDSRQVDGKTLFFA-KGATFKA-DYLKEAITNGLQLYISEVDY-ELGIPVVLVTDIKKAMSLIAMAFygNPQEKLK 112
Cdd:PRK11929 527 GAVSTDSRSVGRGELFVAlRGENFDGhDYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAW--RARFSLP 604

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 113 LLAFTGTKGKTTaayfayhmLKEsykpaMFSTMNTTLDGKTffkSQLTTPES--------LDLFAMM----AECVTNGMT 180
Cdd:PRK11929 605 VVAITGSNGKTT--------TKE-----MIAAILAAWQGED---RVLATEGNfnneigvpLTLLRLRaqhrAAVFELGMN 668

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 181 HlimeVSSQAYLVDRVYGltfDVGVFLNISPDHIG------PIEHPTFEDYFYhkrlLMENSRAVVinSGMDHFSFLADQ 254
Cdd:PRK11929 669 H----PGEIAYLAAIAAP---TVALVTNAQREHQEfmhsveAVARAKGEIIAA----LPEDGVAVV--NGDDPYTAIWAK 735

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 255 VADQEHVFYGPLSDNQITTSQAF----SFEAKGQL-------AGHYDIQL--IGHFNQENAMAAGLACLRLGASLADIQK 321
Cdd:PRK11929 736 LAGARRVLRFGLQPGADVYAEKIakdiSVGEAGGTrcqvvtpAGSAEVYLplIGEHNLRNALAAIACALAAGASLKQIRA 815

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489081000 322 GIAKTR-VPGRMEVLTMTNHAKVFVD-YAHNGDSLEKLLSVVEEHQTGKLMLILGAPGNKGesrraDFGRVIHQ 393
Cdd:PRK11929 816 GLERFQpVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGDMLELG-----DNGPAMHR 884
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 202-349 1.87e-11

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 65.86  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 202 DVGVFLNISPDHIgpiEH-PTFEDYF--YHKRL-LMENSRAVVINSGMDHFSFLADQVaDQEHVFYGPLSDNQITTS--- 274
Cdd:COG0773  173 DIAVVTNIEADHL---DIyGDLEAIKeaFHEFArNVPFYGLLVLCADDPGLRELLPRC-GRPVITYGFSEDADYRAEnir 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 275 -----QAFSFEAKGQLAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAK-TRVPGRMEVLTMTNHAKVFVDYA 348
Cdd:COG0773  249 idgggSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASfKGVKRRFELKGEVGGVTVIDDYA 328


                 .
gi 489081000 349 H 349
Cdd:COG0773  329 H 329
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 110-439 2.71e-08

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 56.13  E-value: 2.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 110 KLKLLAFTGTKGKTTAayfayhmlkesykpamfstmnTTLDGKTFFKSQLTTPESLDL-FAMMAECVTNGM-THLIMEVS 187
Cdd:PRK14106 107 KAPIVAITGTNGKTTT---------------------TTLLGEIFKNAGRKTLVAGNIgYPLIDAVEEYGEdDIIVAEVS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 188 S-QAYLVDRvygLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLMENSRA---VVINSGMDHFSFLADQVADQehVFY 263
Cdd:PRK14106 166 SfQLETIKE---FKPKVGCILNITPDHLD--RHKTMENYIKAKARIFENQRPsdyTVLNYDDPRTRSLAKKAKAR--VIF 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 264 gpLSDNQITTSQAFSFEAK--GQLAGHY-------DIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAKTR-VPGRME 333
Cdd:PRK14106 239 --FSRKSLLEEGVFVKNGKivISLGGKEeevididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKgVEHRIE 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 334 VLTMTNHAKVFVDY-AHNGDSLEKLLSVVEEHqtgklmLILGAPG-NKGESRRaDFGRVIHQHPNLTVIL---------T 402
Cdd:PRK14106 317 FVAEINGVKFINDSkGTNPDAAIKALEAYETP------IVLIAGGyDKGSDFD-EFAKAFKEKVKKLILLgetaqeiaeA 389

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489081000 403 ADDPNFEDpediskeiashiarpVEIISDREQAIQKA 439
Cdd:PRK14106 390 ARKYGFDN---------------ILFAETLEEAVKKA 411
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 38-374 2.32e-07

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 53.42  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  38 LSYDSRQVD--GKTLFFA-KGATFKA-DYLKEAITNGLQLYISEVDYEL-----GIPVVLVTDIKKAMSLIAmAFYGNpQ 108
Cdd:PRK11930  27 ILTDSRSLSfpENTLFFAlKGERNDGhRYIQELYEKGVRNFVVSEEKHPeesypDANFLKVKDPLKALQELA-AYHRS-Q 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 109 EKLKLLAFTGTKGKTTAAYFAYHMLKESYkpamfstmNTTLDGKTfFKSQLTTPESLDLfamMAECVTNGmthlIMEVS- 187
Cdd:PRK11930 105 FDIPVIGITGSNGKTIVKEWLYQLLSPDY--------NIVRSPRS-YNSQIGVPLSVWQ---LNEEHELG----IFEAGi 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 188 SQAYLVDRVYGLTF-DVGVFLNISPDH---IGPIEHPTFEdyfyhKRLLMENSRAVV-----------INSGMDHFSFLA 252
Cdd:PRK11930 169 SQPGEMEALQKIIKpTIGILTNIGGAHqenFRSIKQKIME-----KLKLFKDCDVIIyngdnelisscITKSNLTLKLIS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 253 DQVADQEHVFYGPLSDNQiTTSQAFSFEAKGQlAGHYDIQLIGHFNQENAMAAGLACLRLGASLADIQKGIAK-TRVPGR 331
Cdd:PRK11930 244 WSRKDPEAPLYIPFVEKK-EDHTVISYTYKGE-DFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARlEPVAMR 321

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 489081000 332 MEVLTMTNHAkVFVDYAHNGD--SLEKLLSVVEEH-QTGKLMLILG 374
Cdd:PRK11930 322 LEVKEGINNC-TLINDSYNSDlqSLDIALDFLNRRsQSKKKTLILS 366
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 1-332 6.71e-03

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 38.86  E-value: 6.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000   1 MI--TIEQLLDILkkdhnfrevldadGYHYHYQGLSFERLSYDSRQVDGKTLFFA-KGATFKA-DYLKEAITNGL-QLYI 75
Cdd:PRK10773   1 MIsvTLSQLADIL-------------NGELQGADITIDAVTTDTRKVTPGCLFVAlKGERFDAhDFADDAKAAGAgALLV 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000  76 SEVdYELGIPVVLVTDIKKAMSliAMAFYGNPQEKLKLLAFTGTKGKTTaayfayhmLKEsYKPAMFSTMNTTLDGKTFF 155
Cdd:PRK10773  68 SRP-LDIDLPQLVVKDTRLAFG--QLAAWVRQQVPARVVALTGSSGKTS--------VKE-MTAAILRQCGNTLYTAGNL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 156 KSQLTTPesLDLFAMMAE----CVTNGMTHlIMEVssqAYLVDRVYGLTFDVGvflNISPDHI-------------GPIe 218
Cdd:PRK10773 136 NNDIGVP--LTLLRLTPEhdyaVIELGANH-QGEI---AYTVSLTRPEAALVN---NLAAAHLegfgslagvakakGEI- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489081000 219 hptfedyFYHkrlLMENSRAVvIN----------SGMDH-----FSFLADQVADqehvFYGplSDNQITtSQAFSFEAKG 283
Cdd:PRK10773 206 -------FSG---LPENGIAI-MNadsndwlnwqSVIGSktvwrFSPNAANSVD----FTA--TNIHVT-SHGTEFTLHT 267

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489081000 284 QLaGHYDIQL--IGHFNQENAMAAGLACLRLGASLADIQKGIAKTR-VPGRM 332
Cdd:PRK10773 268 PT-GSVDVLLplPGRHNIANALAAAALAMSVGATLDAVKAGLANLKaVPGRL 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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