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Conserved domains on  [gi|489078550|ref|WP_002988490|]
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Xaa-Pro peptidase family protein [Streptococcus pyogenes]

Protein Classification

M24 family metallopeptidase( domain architecture ID 11414248)

M24 family metallopeptidase cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.90.230.10
EC:  3.4.-.-
Gene Ontology:  GO:0008233|GO:0016787|GO:0004177|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24|M24B
PubMed:  7674922|16229471|30536999
SCOP:  3000126

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
13-357 4.95e-113

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


:

Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 330.63  E-value: 4.95e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  13 LRQMAEKGLEALLVTHLTNSYYLTGFSGTA---ATVLITAK-RRVLITDSRYTllakasvegfdiiesrtplkvvaellE 88
Cdd:COG0006    4 RALMAEAGLDALLLTDPSNFAYLTGFRGSPerlAALLVTADgEPVLFVDELEA--------------------------E 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  89 ADQIDClgfedqvsfsfyqamqaelsgitllaqSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERDL 168
Cdd:COG0006   58 RELVDA---------------------------SDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVT-EREV 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 169 ANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYAL 248
Cdd:COG0006  110 AAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEA 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 249 VLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGK-SEQLLQAGMVVTDEPGIYLDN 327
Cdd:COG0006  190 VLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPgNDRPLEPGMVFTIEPGIYIPG 269

                        330       340       350
                 ....*....|....*....|....*....|
gi 489078550 328 KYGVRIEDDLVITKTGCQVLTLAPKELIVL 357
Cdd:COG0006  270 IGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
13-357 4.95e-113

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 330.63  E-value: 4.95e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  13 LRQMAEKGLEALLVTHLTNSYYLTGFSGTA---ATVLITAK-RRVLITDSRYTllakasvegfdiiesrtplkvvaellE 88
Cdd:COG0006    4 RALMAEAGLDALLLTDPSNFAYLTGFRGSPerlAALLVTADgEPVLFVDELEA--------------------------E 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  89 ADQIDClgfedqvsfsfyqamqaelsgitllaqSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERDL 168
Cdd:COG0006   58 RELVDA---------------------------SDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVT-EREV 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 169 ANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYAL 248
Cdd:COG0006  110 AAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEA 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 249 VLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGK-SEQLLQAGMVVTDEPGIYLDN 327
Cdd:COG0006  190 VLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPgNDRPLEPGMVFTIEPGIYIPG 269

                        330       340       350
                 ....*....|....*....|....*....|
gi 489078550 328 KYGVRIEDDLVITKTGCQVLTLAPKELIVL 357
Cdd:COG0006  270 IGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 137-344 3.97e-110

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 319.84  E-value: 3.97e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSISDKAFEDALDFIKPGTTtERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTM 216
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMT-EREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 217 DFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGL 296
Cdd:cd01092   80 DFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRTGHGVGL 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489078550 297 DIHENPFFGK-SEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGC 344
Cdd:cd01092  160 EVHEAPYISPgSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTEDGC 208
PRK09795 PRK09795
aminopeptidase; Provisional
 13-356 3.18e-81

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 251.78  E-value: 3.18e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  13 LRQ-MAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDI---IESRTPLKVVAELLE 88
Cdd:PRK09795   7 LRDwLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARAQGYQLhllDATNTLTTIVNQIIA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  89 ADQIDCLGFE-DQVSFSFYQAMQAELSGiTLLAQSgfVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERD 167
Cdd:PRK09795  87 DEQLQTLGFEgQQVSWETAHRWQSELNA-KLVSAT--PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMS-ERE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 168 LANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHI-GQVTDEERE-- 244
Cdd:PRK09795 163 IAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVnGEGVSAESHpl 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 245 --IYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGKSE-QLLQAGMVVTDEP 321
Cdd:PRK09795 243 fnVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRDtTTLQPGMLLTVEP 322

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 489078550 322 GIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIV 356
Cdd:PRK09795 323 GIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLL 357
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 140-341 3.13e-78

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 238.68  E-value: 3.13e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  140 IAKACSISDKAFEDALDFIKPGTTtERDLANFLD-FRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDF 218
Cdd:pfam00557   3 MRKAARIAAAALEAALAAIRPGVT-ERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  219 GCYYNH-YVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLD 297
Cdd:pfam00557  82 GAEYDGgYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGLE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 489078550  298 IHENPFF--GKSEQLLQAGMVVTDEPGIY-LDNKYGVRIEDDLVITK 341
Cdd:pfam00557 162 VHEGPYIsrGGDDRVLEPGMVFTIEPGIYfIPGWGGVRIEDTVLVTE 208
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 131-350 9.97e-19

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 84.32  E-value: 9.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTT---ERDLANFLDFR------MRQYGASG---TSFDIIVAsgyrsam 198
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTkelDRIAKDFIEKHgakpafLGYYGFPGsvcISVNEVVI------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  199 pHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLIT 278
Cdd:TIGR00500  76 -HGIPDKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  279 EAGYGSHFTHGiGHGIGLDIHENPF---FGKSEQ--LLQAGMVVTDEPGI-----------------YLDNKYGVRIEDD 336
Cdd:TIGR00500 155 AKGFSVVREYC-GHGIGRKFHEEPQipnYGKKFTnvRLKEGMVFTIEPMVntgteeittaadgwtvkTKDGSLSAQFEHT 233

                         250
                  ....*....|....
gi 489078550  337 LVITKTGCQVLTLA 350
Cdd:TIGR00500 234 IVITDNGPEILTER 247
 
Name Accession Description Interval E-value
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
13-357 4.95e-113

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 330.63  E-value: 4.95e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  13 LRQMAEKGLEALLVTHLTNSYYLTGFSGTA---ATVLITAK-RRVLITDSRYTllakasvegfdiiesrtplkvvaellE 88
Cdd:COG0006    4 RALMAEAGLDALLLTDPSNFAYLTGFRGSPerlAALLVTADgEPVLFVDELEA--------------------------E 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  89 ADQIDClgfedqvsfsfyqamqaelsgitllaqSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERDL 168
Cdd:COG0006   58 RELVDA---------------------------SDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVT-EREV 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 169 ANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYAL 248
Cdd:COG0006  110 AAELEAAMRRRGAEGPSFDTIVASGENAAIPHYTPTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEA 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 249 VLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGK-SEQLLQAGMVVTDEPGIYLDN 327
Cdd:COG0006  190 VLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGEYFPHGTGHGVGLDVHEGPQISPgNDRPLEPGMVFTIEPGIYIPG 269

                        330       340       350
                 ....*....|....*....|....*....|
gi 489078550 328 KYGVRIEDDLVITKTGCQVLTLAPKELIVL 357
Cdd:COG0006  270 IGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 137-344 3.97e-110

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 319.84  E-value: 3.97e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSISDKAFEDALDFIKPGTTtERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTM 216
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMT-EREVAAELEYFMRKLGAEGPSFDTIVASGPNSALPHGVPSDRKIEEGDLVLI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 217 DFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGL 296
Cdd:cd01092   80 DFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGEYFIHRTGHGVGL 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489078550 297 DIHENPFFGK-SEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGC 344
Cdd:cd01092  160 EVHEAPYISPgSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLVTEDGC 208
PRK09795 PRK09795
aminopeptidase; Provisional
 13-356 3.18e-81

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 251.78  E-value: 3.18e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  13 LRQ-MAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDI---IESRTPLKVVAELLE 88
Cdd:PRK09795   7 LRDwLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARAQGYQLhllDATNTLTTIVNQIIA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  89 ADQIDCLGFE-DQVSFSFYQAMQAELSGiTLLAQSgfVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERD 167
Cdd:PRK09795  87 DEQLQTLGFEgQQVSWETAHRWQSELNA-KLVSAT--PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMS-ERE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 168 LANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHI-GQVTDEERE-- 244
Cdd:PRK09795 163 IAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVnGEGVSAESHpl 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 245 --IYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLDIHENPFFGKSE-QLLQAGMVVTDEP 321
Cdd:PRK09795 243 fnVYQIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRDtTTLQPGMLLTVEP 322

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 489078550 322 GIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIV 356
Cdd:PRK09795 323 GIYLPGQGGVRIEDVVLVTPQGAEVLYAMPKTVLL 357
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 140-341 3.13e-78

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 238.68  E-value: 3.13e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  140 IAKACSISDKAFEDALDFIKPGTTtERDLANFLD-FRMRQYGASGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTMDF 218
Cdd:pfam00557   3 MRKAARIAAAALEAALAAIRPGVT-ERELAAELEaARLRRGGARGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  219 GCYYNH-YVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGLD 297
Cdd:pfam00557  82 GAEYDGgYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFPHGLGHGIGLE 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 489078550  298 IHENPFF--GKSEQLLQAGMVVTDEPGIY-LDNKYGVRIEDDLVITK 341
Cdd:pfam00557 162 VHEGPYIsrGGDDRVLEPGMVFTIEPGIYfIPGWGGVRIEDTVLVTE 208
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 137-344 3.42e-60

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 192.67  E-value: 3.42e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSISDKAFEDALDFIKPGTTtERDLANFLDFRMRQYGAsGTSFDIIVASGYRSAMPHGRASDKVIQNKESLTM 216
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVT-EAEVAAAIEQALRAAGG-YPAGPTIVGSGARTALPHYRPDDRRLQEGDLVLV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 217 DFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHGIGL 296
Cdd:cd01066   79 DLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGHRTGHGIGL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 489078550 297 DIHENPFFGK-SEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGC 344
Cdd:cd01066  159 EIHEPPVLKAgDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTEDGP 207
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 137-348 1.42e-49

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 166.21  E-value: 1.42e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSISDKAFEDALDFIKPGTTtERDLANFLDFRMRQYGAS-GTSFDIIVASGyrSAMPHGRASDKVIQNKESLT 215
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMS-EYELEAEFEYEFRSRGARlAYSYIVAAGSN--AAILHYVHNDQPLKDGDLVL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 216 MDFGCYYNHYVSDMTRTIHI-GQVTDEEREIYALVLAANKALIAKAIAGMTYSDFD--------------GI---PRQLI 277
Cdd:cd01087   78 IDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHllahrvlaeglkelGIlkgDVDEI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 278 TEAGYGSHF-THGIGHGIGLDIHENPFFGKSE---QLLQAGMVVTDEPGIY------LDNKY----GVRIEDDLVITKTG 343
Cdd:cd01087  158 VESGAYAKFfPHGLGHYLGLDVHDVGGYLRYLrraRPLEPGMVITIEPGIYfipdllDVPEYfrggGIRIEDDVLVTEDG 237


                 ....*
gi 489078550 344 CQVLT 348
Cdd:cd01087  238 PENLT 242
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 164-343 2.57e-41

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 144.24  E-value: 2.57e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 164 TERDLANFLD-FRMRQYGASGTSFDIIVASGYRSAMPHGRA---SDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVT 239
Cdd:cd01085   31 TELSAADKLEeFRRQQKGYVGLSFDTISGFGPNGAIVHYSPteeSNRKISPDGLYLIDSGGQYLDGTTDITRTVHLGEPT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 240 DEEREIYALVLAANKALiAKAI--AGMTYSDFDGIPRQLITEAG--YGshftHGIGHGIG--LDIHENP---FFGKSEQL 310
Cdd:cd01085  111 AEQKRDYTLVLKGHIAL-ARAKfpKGTTGSQLDALARQPLWKAGldYG----HGTGHGVGsfLNVHEGPqsiSPAPNNVP 185

                        170       180       190
                 ....*....|....*....|....*....|...
gi 489078550 311 LQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTG 343
Cdd:cd01085  186 LKAGMILSNEPGYYKEGKYGIRIENLVLVVEAE 218
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 125-348 4.07e-31

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 122.14  E-value: 4.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 125 VEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTtERDLANFLDFRMRQYGASGTSFDIIVASGYRSAMPHGRAS 204
Cdd:PRK10879 167 VHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMF-EYQLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTEN 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 205 DKVIQNKESLTMDFGCYYNHYVSDMTRTIHI-GQVTDEEREIYALVLAA-NKAL--------IAKAIAGMTYSDFDGIPR 274
Cdd:PRK10879 246 ESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESlETSLrlyrpgtsIREVTGEVVRIMVSGLVK 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 275 ---------QLITEAGYGSHFTHGIGHGIGLDIHENPFFGKS-EQLLQAGMVVTDEPGIYL------DNKY---GVRIED 335
Cdd:PRK10879 326 lgilkgdvdQLIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDrSRILEPGMVLTVEPGLYIapdadvPEQYrgiGIRIED 405

                        250
                 ....*....|...
gi 489078550 336 DLVITKTGCQVLT 348
Cdd:PRK10879 406 DIVITETGNENLT 418
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 137-349 5.88e-27

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 106.42  E-value: 5.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSISDKAFEDALDFIKPGTTTErDLANFLDFRMRQYGASgTSF---------------DIIVasgyrsampHG 201
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTK-ELDQIAHEFIEEHGAY-PAPlgyygfpksictsvnEVVC---------HG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 202 RASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEReiyALVLAANKAL---IAKAIAGMTYSDFDGIPRQLIT 278
Cdd:cd01086   70 IPDDRVLKDGDIVNIDVGVELDGYHGDSARTFIVGEVSEEAK---KLVEVTEEALykgIEAVKPGNRIGDIGHAIEKYAE 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 279 EAGYGS--HFThgiGHGIGLDIHENPF---FGKSEQ--LLQAGMVVTDEPGIYL-----------------DNKYGVRIE 334
Cdd:cd01086  147 KNGYSVvrEFG---GHGIGRKFHEEPQipnYGRPGTgpKLKPGMVFTIEPMINLgtyevvtlpdgwtvvtkDGSLSAQFE 223

                        250
                 ....*....|....*
gi 489078550 335 DDLVITKTGCQVLTL 349
Cdd:cd01086  224 HTVLITEDGPEILTL 238
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
131-353 2.18e-25

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 102.78  E-value: 2.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTERdlanfLDfrmrQYGAsgtsfDIIVASGYRSAM------P----- 199
Cdd:COG0024    3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLE-----LD----RIAE-----EFIRDHGAIPAFlgyygfPksict 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 200 -------HGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREiyaLVLAANKAL---IAKAIAGMTYSDf 269
Cdd:COG0024   69 svnevvvHGIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARR---LVEVTEEALyagIAAAKPGNRLGD- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 270 dgIPR---QLITEAGYG--SHFThgiGHGIGLDIHENPF---FGKSEQ--LLQAGMVVTDEPGIYLDnKYGVRIEDD--- 336
Cdd:COG0024  145 --IGHaiqSYAESNGYSvvREFV---GHGIGREMHEEPQvpnYGRPGRgpRLKPGMVLAIEPMINAG-TPEVKVLDDgwt 218

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489078550 337 ---------------LVITKTGCQVLTLAPKE 353
Cdd:COG0024  219 vvtkdgslsaqfehtVAVTEDGPEILTLPDGG 250
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 8-131 5.14e-25

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 98.14  E-value: 5.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550    8 RLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVL-ITAKRRVLITD-SRYTLLAKASVEGFDII---ESRTPLKV 82
Cdd:pfam01321   1 RLEKLRKLMEEKGLDAALVTSPENLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAESAPDFDVVpyrDYEALADL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 489078550   83 VAELLEADQIdcLGFE-DQVSFSFYQAMQAELSGITLLAQSGFVEHLRFI 131
Cdd:pfam01321  81 LKELGAGGKR--VGFEaDALTVAFYEALKEALPGAELVDVSGLIERLRMV 128
PRK05716 PRK05716
methionine aminopeptidase; Validated
 131-353 7.37e-21

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 90.19  E-value: 7.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTER--DLANflDFrMRQYGA-------SG------TSFDIIVAsgyr 195
Cdd:PRK05716   5 IKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKEldRIAE--EY-IRDQGAipaplgyHGfpksicTSVNEVVC---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 196 sampHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEReiyALVLAANKAL---IAKAIAGMTYSDFDGI 272
Cdd:PRK05716  78 ----HGIPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDK---RLCEVTKEALylgIAAVKPGARLGDIGHA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 273 PRQLITEAGYG--SHFThgiGHGIGLDIHENPF---FGKSEQ--LLQAGMVVTDEPGIYLdNKYGVRIEDD--------- 336
Cdd:PRK05716 151 IQKYAEAEGFSvvREYC---GHGIGRKFHEEPQiphYGAPGDgpVLKEGMVFTIEPMINA-GKREVKTLKDgwtvvtkdg 226

                        250       260
                 ....*....|....*....|....*.
gi 489078550 337 ---------LVITKTGCQVLTLAPKE 353
Cdd:PRK05716 227 slsaqyehtVAVTEDGPEILTLRPEE 252
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 130-350 2.68e-19

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 86.04  E-value: 2.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 130 FIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTeRDLANFLDFRMRQYGA-------------SGTSFDIIVAsgyrs 196
Cdd:PRK12896   9 EIKSPRELEKMRKIGRIVATALKEMGKAVEPGMTT-KELDRIAEKRLEEHGAipspegyygfpgsTCISVNEEVA----- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 197 ampHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREiyaLVLAANKAL---IAKAIAGMTYSDFDGIP 273
Cdd:PRK12896  83 ---HGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEK---LCRVAEEALwagIKQVKAGRPLNDIGRAI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 274 RQLITEAGYG--SHFThgiGHGIGLDIHENP----FFGKS--EQLLQAGMVVTDEPGIYL-----------------DNK 328
Cdd:PRK12896 157 EDFAKKNGYSvvRDLT---GHGVGRSLHEEPsvilTYTDPlpNRLLRPGMTLAVEPFLNLgakdaetlddgwtvvtpDKS 233

                        250       260
                 ....*....|....*....|..
gi 489078550 329 YGVRIEDDLVITKTGCQVLTLA 350
Cdd:PRK12896 234 LSAQFEHTVVVTRDGPEILTDR 255
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 131-350 9.97e-19

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 84.32  E-value: 9.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTT---ERDLANFLDFR------MRQYGASG---TSFDIIVAsgyrsam 198
Cdd:TIGR00500   3 LKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTkelDRIAKDFIEKHgakpafLGYYGFPGsvcISVNEVVI------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  199 pHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLIT 278
Cdd:TIGR00500  76 -HGIPDKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  279 EAGYGSHFTHGiGHGIGLDIHENPF---FGKSEQ--LLQAGMVVTDEPGI-----------------YLDNKYGVRIEDD 336
Cdd:TIGR00500 155 AKGFSVVREYC-GHGIGRKFHEEPQipnYGKKFTnvRLKEGMVFTIEPMVntgteeittaadgwtvkTKDGSLSAQFEHT 233

                         250
                  ....*....|....
gi 489078550  337 LVITKTGCQVLTLA 350
Cdd:TIGR00500 234 IVITDNGPEILTER 247
PRK12897 PRK12897
type I methionyl aminopeptidase;
131-348 1.72e-18

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 83.54  E-value: 1.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTeRDLANFLDFRMRQYGASG-----TSFDIIVASGYRSAMPHGRASD 205
Cdd:PRK12897   4 IKTKNEIDLMHESGKLLASCHREIAKIMKPGITT-KEINTFVEAYLEKHGATSeqkgyNGYPYAICASVNDEMCHAFPAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 206 KVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREiyaLVLAANKAL---IAKAIAGMTYSDFDGIPRQLITEAGY 282
Cdd:PRK12897  83 VPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEK---LLLVAENALykgIDQAVIGNRVGDIGYAIESYVANEGF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 283 --GSHFThgiGHGIGLDIHENP---FFGKSEQ--LLQAGMVVTDEPGI-----------------YLDNKYGVRIEDDLV 338
Cdd:PRK12897 160 svARDFT---GHGIGKEIHEEPaifHFGKQGQgpELQEGMVITIEPIVnvgmryskvdlngwtarTMDGKLSAQYEHTIA 236

                        250
                 ....*....|
gi 489078550 339 ITKTGCQVLT 348
Cdd:PRK12897 237 ITKDGPIILT 246
PRK12318 PRK12318
methionyl aminopeptidase;
131-349 2.31e-18

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 84.10  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 131 IKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTER--DLANFLDfrmRQYGA-------SGTSFDIIVASGYRSAMPHG 201
Cdd:PRK12318  43 IKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNEldELSRELH---KEYNAipaplnyGSPPFPKTICTSLNEVICHG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 202 RASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIyalVLAANKALIAkAIAGMTysdfDGIPRQLITEA- 280
Cdd:PRK12318 120 IPNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKV---CQASLECLNA-AIAILK----PGIPLYEIGEVi 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 281 -----GYG-SHFTHGIGHGIGLDIHENPFF----GKSEQLLQAGMVVTDEPGIYL------------------DNKYGVR 332
Cdd:PRK12318 192 encadKYGfSVVDQFVGHGVGIKFHENPYVphhrNSSKIPLAPGMIFTIEPMINVgkkegvidpinhweartcDNQPSAQ 271

                        250
                 ....*....|....*..
gi 489078550 333 IEDDLVITKTGCQVLTL 349
Cdd:PRK12318 272 WEHTILITETGYEILTL 288
PRK13607 PRK13607
proline dipeptidase; Provisional
 213-348 8.20e-15

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 74.93  E-value: 8.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 213 SLTMDFGCYYNHYVSDMTRTIhigqVTDEEREIYALVLAANK---ALIAKAIAGMTYSD---------------FD---G 271
Cdd:PRK13607 242 SFLIDAGAEYNGYAADITRTY----AAKEDNDFAALIKDVNKeqlALIATMKPGVSYVDlhiqmhqriakllrkFQivtG 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 272 IPRQLITEAGYGSHF-THGIGHGIGLDIH------------------ENPFFgKSEQLLQAGMVVTDEPGIY-------- 324
Cdd:PRK13607 318 LSEEAMVEQGITSPFfPHGLGHPLGLQVHdvagfmqddrgthlaapeKHPYL-RCTRVLEPGMVLTIEPGLYfidsllap 396

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489078550 325 -LDNKY----------------GVRIEDDLVITKTGCQVLT 348
Cdd:PRK13607 397 lREGPFskhfnwqkidalkpfgGIRIEDNVVVHENGVENMT 437
PRK15173 PRK15173
peptidase; Provisional
 107-355 7.07e-14

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 71.67  E-value: 7.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 107 QAMQAELSGITLLAQSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYGASGTSF 186
Cdd:PRK15173  71 RVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRF 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 187 DIIVASGYRSamPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTY 266
Cdd:PRK15173 151 HLISVGADFS--PKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKM 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 267 SDFDGIPRQLITEAGYGSHFTHGIGHGIG--LDIHENPFFGK-SEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTG 343
Cdd:PRK15173 229 KDVFDSTMEVIKKSGLPNYNRGHLGHGNGvfLGLEESPFVSThATESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEG 308

                        250
                 ....*....|..
gi 489078550 344 CQVLTLAPKELI 355
Cdd:PRK15173 309 IEFLSKLPRDLV 320
PRK14575 PRK14575
putative peptidase; Provisional
 107-355 1.66e-13

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 70.89  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 107 QAMQAELSGITLLAQSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYGASGTSF 186
Cdd:PRK14575 154 RVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRF 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 187 DIIVASGYRSamPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTY 266
Cdd:PRK14575 234 HLISVGADFS--PKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKM 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 267 SDFDGIPRQLITEAGYGSHFTHGIGHGIG--LDIHENPFFGK-SEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTG 343
Cdd:PRK14575 312 KDVFDSTMEVIKKSGLPNYNRGHLGHGNGvfLGLEESPFVSThATESFTSGMVLSLETPYYGYNLGSIMIEDMILINKEG 391

                        250
                 ....*....|..
gi 489078550 344 CQVLTLAPKELI 355
Cdd:PRK14575 392 IEFLSKLPRDLV 403
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 113-348 5.45e-10

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 60.24  E-value: 5.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 113 LSGITLLAQSGFVEHLRFIKDTSEIDTIAKACSISDKAFEDALDFIKPGTTTERdlanfLDFRMRQygasgtsfDIIVAS 192
Cdd:PLN03158 119 LDGTPKIEPNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDE-----IDRVVHE--------ATIAAG 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 193 GYRSAM-----P------------HGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDEEREiyaLVLAANKA 255
Cdd:PLN03158 186 GYPSPLnyhffPkscctsvnevicHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQ---LVKCTYEC 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 256 LiAKAIA----GMTYSDFDGIPRQLITEAGYgSHFTHGIGHGIGLDIH---ENPFFG--KSEQLLQAGMVVTDEPGI--- 323
Cdd:PLN03158 263 L-EKAIAivkpGVRYREVGEVINRHATMSGL-SVVKSYCGHGIGELFHcapNIPHYArnKAVGVMKAGQVFTIEPMInag 340

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 489078550 324 --------------YLDNKYGVRIEDDLVITKTGCQVLT 348
Cdd:PLN03158 341 vwrdrmwpdgwtavTADGKRSAQFEHTLLVTETGVEVLT 379
PRK14576 PRK14576
putative endopeptidase; Provisional
 16-354 3.00e-08

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 55.02  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  16 MAEKGLEALLVTHLTNSYYLTGFSG--------TAATVLITAK-----RRVLITD----SRYTLLAKASVEGF----DII 74
Cdd:PRK14576  20 MEREGIDALVVTVCDNFYYLTGFASffmytfrhTGAAVAIMFRdanipSQIIMNEfeaaSTHFDMPNSVLKTFpvwvDVD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  75 ESRTPL-------KVVAELLEA------DQIDCLGFEDQVSFSFYQAMQ--------AELSGITLLAQSGFVEHLRFIKD 133
Cdd:PRK14576 100 DPRNPHhhykkrdRPIGPPVEAvfslvkNALEDAGVLDKTIAIELQAMSnggkgvldKVAPGLKLVDSTALFNEIRMIKS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 134 TSEIDTIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYGASGTSFDIIVASGYRSamPHGRASDKVIQNKES 213
Cdd:PRK14576 180 PWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLISVGDNFS--PKIIADTTPAKVGDL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 214 LTMDFGCYYNHYVSDMTRTIHIGQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITEAGYGSHFTHGIGHG 293
Cdd:PRK14576 258 IKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPHYNRGHLGHG 337

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489078550 294 IG--LDIHENPFFG-KSEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKEL 354
Cdd:PRK14576 338 DGvfLGLEEVPFVStQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITDSGFEFLSKLDRDL 401
CDC68-like cd01091
Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in ...
 137-316 6.43e-08

Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.


Pssm-ID: 238524 [Multi-domain]  Cd Length: 243  Bit Score: 52.73  E-value: 6.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 137 IDTIAKACSIS----DKAFEDALD-------FIKPGTTTERDLANFLDFRMRQYGASGTSFDI----IVASG--YRSaMP 199
Cdd:cd01091    1 LNNIKKASDATvdvlKKFFVDEVEeiidqekKVTHSKLSDKVEKAIEDKKKYKAKLDPEQLDWcyppIIQSGgnYDL-LK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550 200 HGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIgQVTDEEREIYALVLAANKALIAKAIAGMTYSDFDGIPRQLITE 279
Cdd:cd01091   80 SSSSSDKLLYHFGVIICSLGARYKSYCSNIARTFLI-DPTSEQQKNYNFLLALQEEILKELKPGAKLSDVYQKTLDYIKK 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 489078550 280 AG--YGSHFTHGIGHGIGLDIHENPFF--GKSEQLLQAGMV 316
Cdd:cd01091  159 KKpeLEPNFTKNLGFGIGLEFRESSLIinAKNDRKLKKGMV 199
COG5406 COG5406
Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and ...
 189-352 2.05e-05

Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics];


Pssm-ID: 227693 [Multi-domain]  Cd Length: 1001  Bit Score: 46.54  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  189 IVASGYRSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIhigqVTDEEREI---YALVLAANKALIA----KAI 261
Cdd:COG5406   248 IIQSGGSIDLTPSAFSFPMELTGDVVLLSIGIRYNGYCSNMSRTI----LTDPDSEQqknYEFLYMLQKYILGlvrpGTD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489078550  262 AGMTYSDFDGIPRQliTEAGYGSHFTHGIGHGIGLDIHEN--PFFGKSEQLLQAGMVVTDEPGI------YLDNKYGVRI 333
Cdd:COG5406   324 SGIIYSEAEKYISS--NGPELGPNFIYNVGLMIGIEFRSSqkPFNVKNGRVLQAGCIFNISLGFgnlinpHPKNNYALLL 401

                         170
                  ....*....|....*....
gi 489078550  334 EDDLVITKTGCQVLTLAPK 352
Cdd:COG5406   402 IDTEQISLSNPIVFTDSPK 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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