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Conserved domains on  [gi|489064618|ref|WP_002974640|]
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SMP-30/gluconolactonase/LRE family protein [Leptospira terpstrae]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 11465288)

SMP-30/gluconolactonase/LRE family protein similar to Staphylococcus lactonase drp35 and Zymomonas mobilis gluconolactonase, which hydrolyzes the gluconolactone formed by glucose-fructose oxidoreductase to form gluconate;

CATH:  2.120.10.30
EC:  3.1.1.-
Gene Ontology:  GO:0005515|GO:0046872|GO:0016787
PubMed:  9868369
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 58-259 2.50e-42

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 147.73  E-value: 2.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  58 ESLDVDSDGNIYGGD-KEGRIIKVTLK-GEIKVIAKTSGRPLGIQFDKQGNLIIADAYKGLLSLD-KSGKLTVLVSEFqG 134
Cdd:COG3386   11 EGPVWDPDGRLYWVDiPGGRIHRYDPDgGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDpADGEVTVLADEY-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 135 KPFQFTDDLDIAQDGRIYFSDASVYeqkeylydlleaRPYGRVFVYDPkTKETELLADGLYFANGIALSKNEDFLLVNET 214
Cdd:COG3386   90 KPLNRPNDGVVDPDGRLYFTDMGEY------------LPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489064618 215 YRYKITKLWLKGPKK-GIKETVIE--NLPGFPDNITRNENGEFWVALF 259
Cdd:COG3386  157 GAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 58-259 2.50e-42

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 147.73  E-value: 2.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  58 ESLDVDSDGNIYGGD-KEGRIIKVTLK-GEIKVIAKTSGRPLGIQFDKQGNLIIADAYKGLLSLD-KSGKLTVLVSEFqG 134
Cdd:COG3386   11 EGPVWDPDGRLYWVDiPGGRIHRYDPDgGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDpADGEVTVLADEY-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 135 KPFQFTDDLDIAQDGRIYFSDASVYeqkeylydlleaRPYGRVFVYDPkTKETELLADGLYFANGIALSKNEDFLLVNET 214
Cdd:COG3386   90 KPLNRPNDGVVDPDGRLYFTDMGEY------------LPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489064618 215 YRYKITKLWLKGPKK-GIKETVIE--NLPGFPDNITRNENGEFWVALF 259
Cdd:COG3386  157 GAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 141-227 3.61e-26

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 99.82  E-value: 3.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  141 DDLDIA-QDGRIYFSDAS-VYEQKEYLYDLLEARPYGRVFVYDPKTKETELLADGLYFANGIALSKNEDFLLVNETYRYK 218
Cdd:pfam03088   1 NALDVDpETGVLYFTDSSsRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 489064618  219 ITKLWLKGP 227
Cdd:pfam03088  81 ISRYWIKEP 89
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 59-222 2.93e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 60.02  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  59 SLDVDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSG-------RPLGIQFDKQGNLIIADAYKG-LLSLDKSGKLTVLV 129
Cdd:cd05819   12 GIAVDSSGNIYVADTGNnRIQVFDPDGNFITSFGSFGsgdgqfnEPAGVAVDSDGNLYVADTGNHrIQKFDPDGNFLASF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 130 SEFQGKPFQFTD--DLDIAQDGRIYFSDASvyeqkeylydllearpYGRVFVYDPKTKETELL------ADGLYFANGIA 201
Cdd:cd05819   92 GGSGDGDGEFNGprGIAVDSSGNIYVADTG----------------NHRIQKFDPDGEFLTTFgsggsgPGQFNGPTGVA 155

                        170       180
                 ....*....|....*....|.
gi 489064618 202 LSKNEDfLLVNETYRYKITKL 222
Cdd:cd05819  156 VDSDGN-IYVADTGNHRIQVF 175
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 58-259 2.50e-42

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 147.73  E-value: 2.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  58 ESLDVDSDGNIYGGD-KEGRIIKVTLK-GEIKVIAKTSGRPLGIQFDKQGNLIIADAYKGLLSLD-KSGKLTVLVSEFqG 134
Cdd:COG3386   11 EGPVWDPDGRLYWVDiPGGRIHRYDPDgGAVEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVRFDpADGEVTVLADEY-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 135 KPFQFTDDLDIAQDGRIYFSDASVYeqkeylydlleaRPYGRVFVYDPkTKETELLADGLYFANGIALSKNEDFLLVNET 214
Cdd:COG3386   90 KPLNRPNDGVVDPDGRLYFTDMGEY------------LPTGALYRVDP-DGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489064618 215 YRYKITKLWLKGPKK-GIKETVIE--NLPGFPDNITRNENGEFWVALF 259
Cdd:COG3386  157 GAGRIYRFDLDADGTlGNRRVFADlpDGPGGPDGLAVDADGNLWVALW 204
Str_synth pfam03088
Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid ...
 141-227 3.61e-26

Strictosidine synthase; Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyzes the condensation of tryptamine with secologanin to form strictosidine.


Pssm-ID: 281131 [Multi-domain]  Cd Length: 89  Bit Score: 99.82  E-value: 3.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  141 DDLDIA-QDGRIYFSDAS-VYEQKEYLYDLLEARPYGRVFVYDPKTKETELLADGLYFANGIALSKNEDFLLVNETYRYK 218
Cdd:pfam03088   1 NALDVDpETGVLYFTDSSsRYDRRQVIAAFLEGDATGRLMKYDPTTKVTKVLLDDLYFPNGIALSPDGSFVLFCETPMAR 80


                  ....*....
gi 489064618  219 ITKLWLKGP 227
Cdd:pfam03088  81 ISRYWIKEP 89
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 74-259 1.26e-13

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 69.60  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618   74 EGRIIKVTLKGEIKVIAKTSGRPLGIQFDKQGNLIIADAYkGLLSLD-KSGKLTVLVSEFQG-KPFQFTDDLDIAQDGRI 151
Cdd:pfam08450  21 GGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKD-GVALLDlATGELTPLADPEDDdWPLNRFNDGKVDPDGRF 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  152 YFSDASvyeqkeylYDLLEARPYGRVFVYDPKTKeTELLADGLYFANGIALSKNEDFLLVNETYRYKITK--LWLKGPKK 229
Cdd:pfam08450 100 WFGTMG--------DDEAPGGDPGALYRLDPDGK-LTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAydYDLDGGLI 170

                         170       180       190
                  ....*....|....*....|....*....|..
gi 489064618  230 GIKETVI--ENLPGFPDNITRNENGEFWVALF 259
Cdd:pfam08450 171 SNRRVFAdfKPGLGRPDGMAVDAEGNVWVARW 202
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
60-257 2.89e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.89  E-value: 2.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  60 LDVDSDGNI-YGGDKEGRIIKVTLK-GEIKVIAKTSGR--PLGIQFDKQGNLIIADAYKG-LLSLD-KSGKLTVLVSefq 133
Cdd:COG4257   64 IAVDPDGNLwFTDNGNNRIGRIDPKtGEITTFALPGGGsnPHGIAFDPDGNLWFTDQGGNrIGRLDpATGEVTEFPL--- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 134 GKPFQFTDDLDIAQDGRIYFSDasvyeqkeylydlleaRPYGRVFVYDPKTKETELLA--DGLYFANGIALSKNeDFLLV 211
Cdd:COG4257  141 PTGGAGPYGIAVDPDGNLWVTD----------------FGANAIGRIDPDTGTLTEYAlpTPGAGPRGLAVDPD-GNLWV 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489064618 212 NETYRYKITKLwlkGPKKG-IKETVIENLPGFPDNITRNENGEFWVA 257
Cdd:COG4257  204 ADTGSGRIGRF---DPKTGtVTEYPLPGGGARPYGVAVDGDGRVWFA 247
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 59-222 2.93e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 60.02  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  59 SLDVDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSG-------RPLGIQFDKQGNLIIADAYKG-LLSLDKSGKLTVLV 129
Cdd:cd05819   12 GIAVDSSGNIYVADTGNnRIQVFDPDGNFITSFGSFGsgdgqfnEPAGVAVDSDGNLYVADTGNHrIQKFDPDGNFLASF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 130 SEFQGKPFQFTD--DLDIAQDGRIYFSDASvyeqkeylydllearpYGRVFVYDPKTKETELL------ADGLYFANGIA 201
Cdd:cd05819   92 GGSGDGDGEFNGprGIAVDSSGNIYVADTG----------------NHRIQKFDPDGEFLTTFgsggsgPGQFNGPTGVA 155

                        170       180
                 ....*....|....*....|.
gi 489064618 202 LSKNEDfLLVNETYRYKITKL 222
Cdd:cd05819  156 VDSDGN-IYVADTGNHRIQVF 175
SSL_N pfam20067
Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of ...
 35-80 4.74e-08

Strictosidine synthase-like, N-terminal; This domain is found at the N-terminal of strictosidine synthase-like (SSL) proteins including Adipocyte plasma membrane- associated proteins (APMAPs) from animals, Protein STRICTOSIDINE SYNTHASE-LIKE (SSLs) from Arabidopsis and SGL proteins, being also present in bacterial sequences. It is about 50 amino acids in length. It contains residues involved in metal coordination in the active site. This domain is also found in Gluconolactonase and Sugar lactone lactonase. These proteins share a six-bladed beta-propeller fold structure and have similar structural and mechanistic features to SS (strictosidine synthase) that involve nucleophilic attack on an electrophilic substrate, although they do not catalyze the SS reaction as they lack the catalytic glutamate required for SS activity; they catalyze hydrolytic reactions instead. APMAPs shows similarity with paraoxonases (PON) and has a strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. They are involved in adipocyte differentiation.


Pssm-ID: 437899 [Multi-domain]  Cd Length: 46  Bit Score: 48.64  E-value: 4.74e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489064618   35 GIYAPNTELQKSILLAIGKVKGLESLDVDSDGNIYGGDKEGRIIKV 80
Cdd:pfam20067   1 GPFAPNDRLAGAELIALGGEHGPEDIAVDPDGRLYTGLHDGRIVRM 46
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 34-157 7.12e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.09  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  34 IGIYAPNTELQKSI---LLAIGKVKGLESLDVDSDGNIYGGDKE-GRIIKVTLKGEIKVIAKTSG-------RPLGIQFD 102
Cdd:cd05819  125 IQKFDPDGEFLTTFgsgGSGPGQFNGPTGVAVDSDGNIYVADTGnHRIQVFDPDGNFLTTFGSTGtgpgqfnYPTGIAVD 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489064618 103 KQGNLIIADAYKG-LLSLDKSGKLTVLVSEFQGKPFQFTD--DLDIAQDGRIYFSDAS 157
Cdd:cd05819  205 SDGNIYVADSGNNrVQVFDPDGAGFGGNGNFLGSDGQFNRpsGLAVDSDGNLYVADTG 262
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
52-236 8.18e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 52.71  E-value: 8.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  52 GKVKGLESLDVDSDGNIY----GGDKEGRIIKVTlkGEIKVIA--KTSGRPLGIQFDKQGNLIIADAYKG-LLSLD-KSG 123
Cdd:COG4257   99 GGGSNPHGIAFDPDGNLWftdqGGNRIGRLDPAT--GEVTEFPlpTGGAGPYGIAVDPDGNLWVTDFGANaIGRIDpDTG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 124 KLTVLVSEFQGKPFQFtddLDIAQDGRIYFSDASVyeqkeylydllearpyGRVFVYDPKTKE-TEL-LADGLYFANGIA 201
Cdd:COG4257  177 TLTEYALPTPGAGPRG---LAVDPDGNLWVADTGS----------------GRIGRFDPKTGTvTEYpLPGGGARPYGVA 237

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489064618 202 LSKNeDFLLVNETYRYKITKLwlkGPKKGIKETVI 236
Cdd:COG4257  238 VDGD-GRVWFAESGANRIVRF---DPDTELTEYVL 268
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 60-157 1.20e-06

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 49.45  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  60 LDVDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSG---------------RPLGIQFDKQGNLIIADAYKG-LLSLDKS 122
Cdd:cd14953  192 VAVDAAGNLYVADRGNhRIRKITPDGVVTTVAGTGTagfsgdggataaqlnNPTGVAVDAAGNLYVADSGNHrIRKITPA 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489064618 123 GKLTVLVSEFQG--------KPFQFTDDLDIAQD--GRIYFSDAS 157
Cdd:cd14953  272 GVVTTVAGGGAGfsgdggpaTSAQFNNPTGVAVDaaGNLYVADTG 316
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
94-259 5.78e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 47.32  E-value: 5.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  94 GRPLGIQFDKQGNLIIADAYKG-LLSLD-KSGKLTvlvsEFQGKPFQFTDDLDIAQDGRIYFSDasvyeqkeylydllea 171
Cdd:COG4257   17 SGPRDVAVDPDGAVWFTDQGGGrIGRLDpATGEFT----EYPLGGGSGPHGIAVDPDGNLWFTD---------------- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 172 RPYGRVFVYDPKTKETELLA--DGLYFANGIALSKNEDfLLVNETYRYKITKLwlkGPKKGikETVIENLP---GFPDNI 246
Cdd:COG4257   77 NGNNRIGRIDPKTGEITTFAlpGGGSNPHGIAFDPDGN-LWFTDQGGNRIGRL---DPATG--EVTEFPLPtggAGPYGI 150

                        170
                 ....*....|...
gi 489064618 247 TRNENGEFWVALF 259
Cdd:COG4257  151 AVDPDGNLWVTDF 163
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 94-257 6.06e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 47.20  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  94 GRPLGIQFDKQGNLIIAD-AYKGLLSLD-KSGKLTVLVSEfQGKPFQFTDDLDIAQDGRIYFSDASVyeqkeylydllea 171
Cdd:cd14962   12 TRPYGVAADGRGRIYVADtGRGAVFVFDlPNGKVFVIGNA-GPNRFVSPIGVAIDANGNLYVSDAEL------------- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 172 rpyGRVFVYDPKTKETELLADGLYF--ANGIALSKNEDFLLVNETYRYKITKLWLKG------PKKGIKetvienlPG-- 241
Cdd:cd14962   78 ---GKVFVFDRDGKFLRAIGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGrllfdiGKRGSG-------PGef 147

                        170
                 ....*....|....*..
gi 489064618 242 -FPDNITRNENGEFWVA 257
Cdd:cd14962  148 nLPTDLAVDRDGNLYVT 164
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 59-156 1.86e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 45.72  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  59 SLDVDSDGNIYGGDKEGRIIKV-TLKGEIKVIAKTSG-------RPLGIQFDKQGNLIIADAYKGLLS-LDKSGKLTVLV 129
Cdd:cd14957   69 GIAVDSNGNIYVADTDNNRIQVfNSSGVYQYSIGTGGsgdgqfnGPYGIAVDSNGNIYVADTGNHRIQvFTSSGTFSYSI 148

                         90       100
                 ....*....|....*....|....*....
gi 489064618 130 SEFQGKPFQFTDDLDIA--QDGRIYFSDA 156
Cdd:cd14957  149 GSGGTGPGQFNGPQGIAvdSDGNIYVADT 177
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 59-212 3.12e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  59 SLDVDSDGNIYGGD-KEGRIIKVTLKGEI------KVIAKTSGRPLGIQFDKqGNLIIADAYKG-LLSLDKSGKltvLVS 130
Cdd:cd14963   60 GIAVDSDGNIYVADlYNGRIQVFDPDGKFlkyfpeKKDRVKLISPAGLAIDD-GKLYVSDVKKHkVIVFDLEGK---LLL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 131 EFqGKP------FQFTDDLDIAQDGRIYFSDASvyeqkeylydllearpYGRVFVYDPKTKetelladglyFANGIALSK 204
Cdd:cd14963  136 EF-GKPgsepgeLSYPNGIAVDEDGNIYVADSG----------------NGRIQVFDKNGK----------FIKELNGSP 188


                 ....*...
gi 489064618 205 NEDFLLVN 212
Cdd:cd14963  189 DGKSGFVN 196
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 62-113 5.16e-05

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 44.44  E-value: 5.16e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489064618  62 VDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSGR---------------PLGIQFDKQGNLIIADAY 113
Cdd:cd14953   84 VDAAGNLYVADTGNhRIRKITPDGVVSTLAGTGTAgfsddggataaqfnyPTGVAVDAAGNLYVADTG 151
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 51-156 1.29e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  51 IGKVKGLESLDVDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSGR-------PLGIQFDKQGNLIIADAY-KGLLSLDK 121
Cdd:cd14956   56 PGQFGRPRGLAVDKDGWLYVADYWGdRIQVFTLTGELQTIGGSSGSgpgqfnaPRGVAVDADGNLYVADFGnQRIQKFDP 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489064618 122 SGKltvLVSEFQGKP-----FQFTDDLDIAQDGRIYFSDA 156
Cdd:cd14956  136 DGS---FLRQWGGTGiepgsFNYPRGVAVDPDGTLYVADT 172
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 62-113 1.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 42.90  E-value: 1.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489064618  62 VDSDGNIYGGDKEG-RIIKVTLKGEIKVIAKTSG---------------RPLGIQFDKQGNLIIADAY 113
Cdd:cd14953  139 VDAAGNLYVADTGNhRIRKITPDGVVTTVAGTGGagyagdgpataaqfnNPTGVAVDAAGNLYVADRG 206
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 62-155 2.29e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  62 VDSDGNIYGGDKEGRIIKV-TLKGeiKVIAKTSGR---------PLGIQFDKQGNLIIADAYKGLLS-LDKSGKLtVLVS 130
Cdd:cd14963  155 VDEDGNIYVADSGNGRIQVfDKNG--KFIKELNGSpdgksgfvnPRGIAVDPDGNLYVVDNLSHRVYvFDEQGKE-LFTF 231

                         90       100
                 ....*....|....*....|....*...
gi 489064618 131 EFQGK---PFQFTDDLDIAQDGRIYFSD 155
Cdd:cd14963  232 GGRGKddgQFNLPNGLFIDDDGRLYVTD 259
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 64-205 2.67e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  64 SDGNIYGGDKEGRIIKV-TLKGE-IKVIAKTSGR------PLGIQFDKQGNLIIADAYKGLLS-LDKSGK-LTVLVSEFQ 133
Cdd:cd14963   18 SDGRIYVADTNNHRVQVfDYEGKfKKSFGGPGTGpgefkyPYGIAVDSDGNIYVADLYNGRIQvFDPDGKfLKYFPEKKD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618 134 GKPFQFTDDLDIaQDGRIYFSDASvyeqkeylydllearpYGRVFVYDPKTKetELLADG--------LYFANGIALSKN 205
Cdd:cd14963   98 RVKLISPAGLAI-DDGKLYVSDVK----------------KHKVIVFDLEGK--LLLEFGkpgsepgeLSYPNGIAVDED 158
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 59-157 8.10e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 8.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  59 SLDVDSDGNIYGGDKE-GRIIKVTLKGE-IKVI--AKTSGRPLGIQFDKQGNLI-IADAYKG-LLSLDKSGKltvLVSEF 132
Cdd:cd14962   61 GVAIDANGNLYVSDAElGKVFVFDRDGKfLRAIgaGALFKRPTGIAVDPAGKRLyVVDTLAHkVKVFDLDGR---LLFDI 137

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489064618 133 qGKP------FQFTDDLDIAQDGRIYFSDAS 157
Cdd:cd14962  138 -GKRgsgpgeFNLPTDLAVDRDGNLYVTDTM 167
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 62-111 2.50e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 39.44  E-value: 2.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489064618  62 VDSDGNIYGGDKE-GRIIKVTLKGEIKVIAK--TSGR------------PLGIQFDKQGNLIIAD 111
Cdd:cd14953   30 VDAAGNLYVADRGnHRIRKITPDGVVTTVAGtgTAGFadgggaaaqfntPSGVAVDAAGNLYVAD 94
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 62-186 2.91e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.72  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  62 VDSDGNIYGGDKEGRIIKV--TLKGEIKVIAKTSG----RPLGIQFDKQGNLIIADAYKG-LLSLDKSGKLTVLVsefqG 134
Cdd:cd14962   19 ADGRGRIYVADTGRGAVFVfdLPNGKVFVIGNAGPnrfvSPIGVAIDANGNLYVSDAELGkVFVFDRDGKFLRAI----G 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489064618 135 KPFQFTDDLDIAQD---GRIYFSDASVyeqkeylydllearpyGRVFVYDPKTKE 186
Cdd:cd14962   95 AGALFKRPTGIAVDpagKRLYVVDTLA----------------HKVKVFDLDGRL 133
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 62-155 3.05e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 38.79  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489064618  62 VDSDGNIYGGDKEGRIIKV-TLKGEIKVIAKTSG-------RPLGIQFDKQGNLIIADAYKGLLS-LDKSGkltVLVSEF 132
Cdd:cd14957  119 VDSNGNIYVADTGNHRIQVfTSSGTFSYSIGSGGtgpgqfnGPQGIAVDSDGNIYVADTGNHRIQvFTSSG---TFQYTF 195

                         90       100
                 ....*....|....*....|....*...
gi 489064618 133 QG---KPFQFTDDLDIA--QDGRIYFSD 155
Cdd:cd14957  196 GSsgsGPGQFSDPYGIAvdSDGNIYVAD 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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