|
Name |
Accession |
Description |
Interval |
E-value |
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
8-277 |
4.27e-135 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 382.10 E-value: 4.27e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQE 87
Cdd:COG0656 1 NGVEIPALGLGTWQL-PGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 88 AFAASMERlgldyldlylIHWPNPKPLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPAVN 167
Cdd:COG0656 80 AFEESLERlgldyldlylIHWPGPGPY----------VETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 168 QIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASN 247
Cdd:COG0656 150 QVELHPYLQQRELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIREN 229
|
250 260 270
....*....|....*....|....*....|
gi 489016068 248 LDCFDIELDDADLEVLKNVSGLAGGAPNPD 277
Cdd:COG0656 230 LDAFDFELSDEDMAAIDALDRGERLGPDPD 259
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
12-263 |
7.46e-124 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 353.32 E-value: 7.46e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQEAFAA 91
Cdd:cd19071 1 MPLIGLGTYKL-KPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 92 SMERLGLDYLDLYLIHWPNPkplRENNAWKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPAVNQIRL 171
Cdd:cd19071 80 SLKDLGLDYLDLYLIHWPVP---GKEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIEL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 172 APGVYQTEAVNFCREHEILLEAWGPFGQGE--LFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLD 249
Cdd:cd19071 157 HPYLQQKELVEFCKEHGIVVQAYSPLGRGRrpLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLD 236
|
250
....*....|....
gi 489016068 250 CFDIELDDADLEVL 263
Cdd:cd19071 237 VFDFELSEEDMAAI 250
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
6-277 |
8.77e-111 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 320.88 E-value: 8.77e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19157 4 LNNGVKMPWLGLGVFKVEEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGYDST 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNpkplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19157 84 LKAFEASLERLGLDYLDLYLIHWPV----------KGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19157 154 VNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRII 233
|
250 260 270
....*....|....*....|....*....|..
gi 489016068 246 SNLDCFDIELDDADLEVLKNVSGLAGGAPNPD 277
Cdd:cd19157 234 ENADVFDFELSQEDMDKIDALNENLRVGPDPD 265
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
6-261 |
2.54e-109 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 316.62 E-value: 2.54e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19131 4 LNDGNTIPQLGLGVWQV-SNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYDST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19131 83 LRAFDESLRKLGLDYVDLYLIHWPVPA--------QDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19131 155 VNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIA 234
|
250
....*....|....*.
gi 489016068 246 SNLDCFDIELDDADLE 261
Cdd:cd19131 235 ENFDVFDFELDADDMQ 250
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
6-263 |
2.85e-106 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 308.98 E-value: 2.85e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19126 3 LNNGTRMPWLGLGVFQTPDGDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRARRT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKPLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19126 83 EDAFQESLDRLGLDYVDLYLIHWPGKDKF----------IDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19126 153 VNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIK 232
|
250
....*....|....*...
gi 489016068 246 SNLDCFDIELDDADLEVL 263
Cdd:cd19126 233 ENADIFDFELSEDDMTAI 250
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
6-264 |
4.93e-105 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 305.65 E-value: 4.93e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19133 3 LNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYEKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPnpkplrENNAWkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19133 83 KKAFERSLKRLGLDYLDLYLIHQP------FGDVY-----GAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG--ELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSR 243
Cdd:cd19133 152 VNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGrnNLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPER 231
|
250 260
....*....|....*....|.
gi 489016068 244 IASNLDCFDIELDDADLEVLK 264
Cdd:cd19133 232 IAENFDIFDFELSDEDMEAIA 252
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
12-266 |
2.85e-101 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 296.47 E-value: 2.85e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDS----GIPREELFITTKLWNDIHTYEEAQE 87
Cdd:cd19136 1 MPILGLGTFRLRGEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 88 AFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKRN-AEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPAV 166
Cdd:cd19136 81 ACLGSLERLGTDYLDLYLIHWPGVQGLKPSDPRNAELrRESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 167 NQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELF--QNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRI 244
Cdd:cd19136 161 NQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDLRllEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERI 240
|
250 260
....*....|....*....|..
gi 489016068 245 ASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19136 241 AENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
6-277 |
4.83e-101 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 295.97 E-value: 4.83e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19156 3 LANGVEMPRLGLGVWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYEST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNpkplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19156 83 LAAFEESLEKLGLDYVDLYLIHWPV----------KGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19156 153 VNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQ 232
|
250 260 270
....*....|....*....|....*....|..
gi 489016068 246 SNLDCFDIELDDADLEVLKNVSGLAGGAPNPD 277
Cdd:cd19156 233 ENFDVFDFELTAEEIRQIDGLNTDHRYGPDPD 264
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
6-263 |
1.81e-99 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 291.48 E-value: 1.81e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19132 1 LNDGTQIPAIGFGTYPL-KGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19132 80 LRTIEESLYRLGLDYVDLYLIHWPNPS--------RDLYVEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGE-LFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRI 244
Cdd:cd19132 152 VNQIELHPYFPQAEQRAYHREHGIVTQSWSPLGRGSgLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQ 231
|
250
....*....|....*....
gi 489016068 245 ASNLDCFDIELDDADLEVL 263
Cdd:cd19132 232 RENLAIFDFELSDEDMAAI 250
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
1-263 |
1.02e-93 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 277.28 E-value: 1.02e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 1 MREYLLNNGVGIPVLGFGTWkaQDGEEAYQATLAALK-AGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDI 79
Cdd:cd19135 2 TPTVRLSNGVEMPILGLGTS--HSGGYSHEAVVYALKeCGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQEAFAASMERLGLDYLDLYLIHWPNPkPLRENNAWKKRnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLET 159
Cdd:cd19135 80 YGYESTKQAFEASLKRLGVDYLDLYLLHWPDC-PSSGKNVKETR-AETWRALEELYDEGLCRAIGVSNFLIEHLEQLLED 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 160 ARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSV 239
Cdd:cd19135 158 CSVVPHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKST 237
|
250 260
....*....|....*....|....
gi 489016068 240 TPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19135 238 KEERIKENCQVFDFSLSEEDMATL 261
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
5-265 |
1.88e-90 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 269.92 E-value: 1.88e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRA----IKDSGIPREELFITTKLWNDIH 80
Cdd:cd19116 4 KLNDGNEIPAIALGTWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAirekIAEGVVKREDLFITTKLWNSYH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKRNA-------EVWRAMEALYNLGKIRAIGVSNFLPHHL 153
Cdd:cd19116 84 EREQVEPALRESLKRLGLDYVDLYLIHWPVAFKENNDSESNGDGSlsdidylETWRGMEDLVKLGLTRSIGVSNFNSEQI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGEL---------FQNPAVQAVADKYGKTIAQVAL 224
Cdd:cd19116 164 NRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPrgqtnppprLDDPTLVAIAKKYGKTTAQIVL 243
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489016068 225 AWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKN 265
Cdd:cd19116 244 RYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNS 284
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
6-271 |
6.33e-90 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 268.60 E-value: 6.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHtyEEA 85
Cdd:cd19117 8 LNTGAEIPAVGLGTWQSKPNE-VAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLWCTWH--RRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNP-KPLRENNAWKKRNA-----------EVWRAMEALYNLGKIRAIGVSNFLPHHL 153
Cdd:cd19117 85 EEALDQSLKKLGLDYVDLYLMHWPVPlDPDGNDFLFKKDDGtkdhepdwdfiKTWELMQKLPATGKVKAIGVSNFSIKNL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLET--ARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQ--GELFQNPAVQAVADKYGKTIAQVALAWSLQ 229
Cdd:cd19117 165 EKLLASpsAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGStnAPLLKEPVIIKIAKKHGKTPAQVIISWGLQ 244
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 489016068 230 EGFLPLPKSVTPSRIASNLDCFdiELDDADLEVLKNVSGLAG 271
Cdd:cd19117 245 RGYSVLPKSVTPSRIESNFKLF--TLSDEEFKEIDELHKEYG 284
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
12-261 |
5.05e-87 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 259.51 E-value: 5.05e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQEAFAA 91
Cdd:cd19073 1 IPALGLGTWQLR-GDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 92 SMERLGLDYLDLYLIHWPNP-KPLREnnawkkrnaeVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPAVNQIR 170
Cdd:cd19073 80 SLEKLGTDYVDLLLIHWPNPtVPLEE----------TLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 171 LAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDC 250
Cdd:cd19073 150 FHPFLYQAELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAI 229
|
250
....*....|.
gi 489016068 251 FDIELDDADLE 261
Cdd:cd19073 230 FDWELTSEDVA 240
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
6-263 |
1.23e-86 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 260.36 E-value: 1.23e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK---DSGIP-REELFITTKLWNDIHT 81
Cdd:cd19125 5 LNTGAKIPAVGLGTWQA-DPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKklfEDGVVkREDLFITSKLWCTDHA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWPN------PKPLRENNAwKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEA 155
Cdd:cd19125 84 PEDVPPALEKTLKDLQLDYLDLYLIHWPVrlkkgaHMPEPEEVL-PPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLED 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 156 LLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGE-------LFQNPAVQAVADKYGKTIAQVALAWSL 228
Cdd:cd19125 163 LLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPGttwvkknVLKDPIVTKVAEKLGKTPAQVALRWGL 242
|
250 260 270
....*....|....*....|....*....|....*
gi 489016068 229 QEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19125 243 QRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKF 277
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
6-260 |
3.60e-85 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 255.79 E-value: 3.60e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19127 3 LNNGVEMPALGLGVFQTP-PEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYDKA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPkplrenNAWkKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19127 82 LRGFDASLRRLGLDYVDLYLLHWPVP------NDF-DRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG------------QGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFL 233
Cdd:cd19127 155 VNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGgvmrygasgptgPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVS 234
|
250 260
....*....|....*....|....*..
gi 489016068 234 PLPKSVTPSRIASNLDCFDIELDDADL 260
Cdd:cd19127 235 AIPKSVHPERIAENIDIFDFALSAEDM 261
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
6-277 |
2.68e-84 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 253.84 E-value: 2.68e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDgEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTyeEA 85
Cdd:PRK11565 9 LQDGNVMPQLGLGVWQASN-EEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLWNDDHK--RP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:PRK11565 86 REALEESLKKLQLDYVDLYLMHWPVPA--------IDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG--ELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSR 243
Cdd:PRK11565 158 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGgkGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSR 237
|
250 260 270
....*....|....*....|....*....|....*
gi 489016068 244 IASNLDCFDIELDDADL-EVLKNVSGLAGGaPNPD 277
Cdd:PRK11565 238 IAENFDVFDFRLDKDELgEIAKLDQGKRLG-PDPD 271
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
6-260 |
3.07e-84 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 252.91 E-value: 3.07e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAyQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19130 4 LNDGNSIPQLGYGVFKVPPADTQ-RAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19130 83 AAAFAESLAKLGLDQVDLYLVHWPTPA--------AGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19130 155 VNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERME 234
|
250
....*....|....*
gi 489016068 246 SNLDCFDIELDDADL 260
Cdd:cd19130 235 DNLDVFDFDLTDTEI 249
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
6-263 |
1.10e-82 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 249.39 E-value: 1.10e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDgEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEA 85
Cdd:cd19134 5 LNDDNTMPVIGLGVGELSD-DEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFTAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPA 165
Cdd:cd19134 84 QAACRASLERLGLDYVDLYLIHWPAGR--------EGKYVDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 166 VNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIA 245
Cdd:cd19134 156 VNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIA 235
|
250
....*....|....*...
gi 489016068 246 SNLDCFDIELDDADLEVL 263
Cdd:cd19134 236 SNLDVFDFELTADHMDAL 253
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
1-266 |
2.15e-80 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 244.63 E-value: 2.15e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 1 MREYLLNNGVGIPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAI----KDSGIPREELFITTKLW 76
Cdd:cd19123 1 MKTLPLSNGDLIPALGLGTWKSKPGE-VGQAVKQALEAGYRHIDCAAIYGNEAEIGAALaevfKEGKVKREDLWITSKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 NDIHTYEEAQEAFAASMERLGLDYLDLYLIHWP------NPKPlRENNAWKKRN----AEVWRAMEALYNLGKIRAIGVS 146
Cdd:cd19123 80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPvalkkgVGFP-ESGEDLLSLSpiplEDTWRAMEELVDKGLCRHIGVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 147 NFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGE------------LFQNPAVQAVADK 214
Cdd:cd19123 159 NFSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGDrpaamkaegepvLLEDPVINKIAEK 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489016068 215 YGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19123 239 HGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAAL 290
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
6-263 |
2.29e-79 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 241.55 E-value: 2.29e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEEAyQATLAALKAGYRHIDTAAIYKNEESVGRAIKDS-----GIPREELFITTKLWNDIH 80
Cdd:cd19118 1 LNTGNKIPAIGLGTWQAEPGEVG-AAVKIALKAGYRHLDLAKVYQNQHEVGQALKELlkeepGVKREDLFITSKLWNNSH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWP------------NPKPLRENNAWKKRN---AEVWRAMEALYNLGKIRAIGV 145
Cdd:cd19118 80 RPEYVEPALDDTLKELGLDYLDLYLIHWPvafkptgdlnplTAVPTNGGEVDLDLSvslVDTWKAMVELKKTGKVKSIGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 146 SNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG---QGE--LFQNPAVQAVADKYGKTIA 220
Cdd:cd19118 160 SNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGnnlAGLplLVQHPEVKAIAAKLGKTPA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489016068 221 QVALAWSLQEGFLPLPKSVTPSRIASNLDcfDIELDDADLEVL 263
Cdd:cd19118 240 QVLIAWGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAV 280
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
9-261 |
1.63e-78 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 238.67 E-value: 1.63e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGT----WKAQDGE---EAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIht 81
Cdd:cd19120 1 GSKIPAIAFGTgtawYKSGDDDiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSPGI-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 yEEAQEAFAASMERLGLDYLDLYLIHWPnpkPLRENNawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETAR 161
Cdd:cd19120 79 -KDPREALRKSLAKLGVDYVDLYLIHSP---FFAKEG--GPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 162 MTPAVNQIRLAPGVY--QTEAVNFCREHEILLEAWGP------FGQGELfqNPAVQAVADKYGKTIAQVALAWSLQEGFL 233
Cdd:cd19120 153 IKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPlspltrDAGGPL--DPVLEKIAEKYGVTPAQVLLRWALQKGIV 230
|
250 260
....*....|....*....|....*...
gi 489016068 234 PLPKSVTPSRIASNLDCFDIELDDADLE 261
Cdd:cd19120 231 VVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
8-263 |
7.19e-78 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 236.77 E-value: 7.19e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQE 87
Cdd:cd19140 4 NGVRIPALGLGTYPLT-GEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 88 AFAASMERLGLDYLDLYLIHWPNPK-PLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETARMTPAV 166
Cdd:cd19140 83 SVEESLRKLRTDYVDLLLLHWPNKDvPL----------AETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 167 NQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSL-QEGFLPLPKSVTPSRIA 245
Cdd:cd19140 153 NQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLqQEGVAAIPKATNPERLE 232
|
250
....*....|....*...
gi 489016068 246 SNLDCFDIELDDADLEVL 263
Cdd:cd19140 233 ENLDIFDFTLSDEEMARI 250
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
1-266 |
3.74e-77 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 235.89 E-value: 3.74e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 1 MREYLLNNGVGIPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDS---GIPREELFITTKLWN 77
Cdd:cd19121 1 MTSFKLNTGASIPAVGLGTWQAKAGE-VKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAiagGVKREDLFVTTKLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 78 DIHTyeEAQEAFAASMERLGLDYLDLYLIHWP---NP---KPL-------RENNAWKKRNAEVWRAMEALYNLGKIRAIG 144
Cdd:cd19121 80 TYHR--RVELCLDRSLKSLGLDYVDLYLVHWPvllNPngnHDLfptlpdgSRDLDWDWNHVDTWKQMEKVLKTGKTKAIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 145 VSNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQ--GELFQNPAVQAVADKYGKTIAQV 222
Cdd:cd19121 158 VSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGStgSPLISDEPVVEIAKKHNVGPGTV 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489016068 223 ALAWSLQEGFLPLPKSVTPSRIASNLDCfdIELDDADLEVLKNV 266
Cdd:cd19121 238 LISYQVARGAVVLPKSVTPDRIKSNLEI--IDLDDEDMNKLNDI 279
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
6-263 |
4.94e-76 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 233.82 E-value: 4.94e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK-----DSGIPREELFITTKLWNDIH 80
Cdd:cd19106 1 LHTGQKMPLIGLGTWKSKPGQ-VKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKekvgpGKAVPREDLFVTSKLWNTKH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWP-------NPKPLRENNAWKKRNA---EVWRAMEALYNLGKIRAIGVSNFLP 150
Cdd:cd19106 80 HPEDVEPALRKTLKDLQLDYLDLYLIHWPyafergdNPFPKNPDGTIRYDSThykETWKAMEKLVDKGLVKAIGLSNFNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 151 HHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQ--------GE--LFQNPAVQAVADKYGKTIA 220
Cdd:cd19106 160 RQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSpdrpwakpDEpvLLEEPKVKALAKKYNKSPA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489016068 221 QVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19106 240 QILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQL 282
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
6-263 |
6.15e-74 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 228.45 E-value: 6.15e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKD---SGI-PREELFITTKLWNDIHT 81
Cdd:cd19154 6 LSNGVKMPLIGLGTWQSK-GAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAElleEGVvKREDLFITTKLWTHEHA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKRN----------AEVWRAMEALYNLGKIRAIGVSNFLPH 151
Cdd:cd19154 85 PEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENgmsihdavdvEDVWRGMEKVYDEGLTKAIGVSNFNND 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 152 HLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG---------------QGELFQNPAVQAVADKYG 216
Cdd:cd19154 165 QIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGspgranftkstgvspAPNLLQDPIVKAIAEKHG 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489016068 217 KTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19154 245 KTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATL 291
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
4-267 |
1.44e-69 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 216.72 E-value: 1.44e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 4 YLLNNGVGIPVLGFGTWkAQDGE--EAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKD-----SGIPREELFITTKLW 76
Cdd:cd19122 1 FTLNNGVKIPAVGFGTF-ANEGAkgETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDflkenPSVKREDLFICTKVW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 NDIHTYEEAQEAFAASMERLGLDYLDLYLIHWP-------------NPKPLRENNAWKKRNAE-VWRAMEALYNLGKIRA 142
Cdd:cd19122 80 NHLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPiaaekndqrspklGPDGKYVILKDLTENPEpTWRAMEEIYESGKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 143 IGVSNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQ-------GE-LFQNPAVQAVADK 214
Cdd:cd19122 160 IGVSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSqnqvpstGErVSENPTLNEVAEK 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489016068 215 YGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDcfDIELDDADLEVLKNVS 267
Cdd:cd19122 240 GGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFK--SIELSDEDFEAINQVA 290
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
12-261 |
3.35e-66 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 206.82 E-value: 3.35e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQDgEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQEAFAA 91
Cdd:cd19139 1 IPAFGLGTFRLKD-DVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 92 SMERLGLDYLDLYLIHWPNPK---PLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNF-LPHHLEALLETARMTPAVN 167
Cdd:cd19139 80 SLEKLRTDYVDLTLIHWPSPNdevPV----------EEYIGALAEAKEQGLTRHIGVSNFtIALLDEAIAVVGAGAIATN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 168 QIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASN 247
Cdd:cd19139 150 QIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSN 229
|
250
....*....|....
gi 489016068 248 LDCFDIELDDADLE 261
Cdd:cd19139 230 LLALDLTLDADDMA 243
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
3-266 |
2.54e-64 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 203.87 E-value: 2.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 3 EYLLNNGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK---DSG-IPREELFITTKLWND 78
Cdd:cd19112 2 TITLNSGHKMPVIGLGVWRM-EPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAeafKTGlVKREDLFITTKLWNS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 79 IHtyEEAQEAFAASMERLGLDYLDLYLIHWPNP----------KPLRENNAWKK----RNAEVWRAMEALYNLGKIRAIG 144
Cdd:cd19112 81 DH--GHVIEACKDSLKKLQLDYLDLYLVHFPVAtkhtgvgttgSALGEDGVLDIdvtiSLETTWHAMEKLVSAGLVRSIG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 145 VSNFLPHHLEALLETARMTPAVNQIRLAPgVYQTEA-VNFCREHEILLEAWGPFGQG----ELF------QNPAVQAVAD 213
Cdd:cd19112 159 ISNYDIFLTRDCLAYSKIKPAVNQIETHP-YFQRDSlVKFCQKHGISVTAHTPLGGAaanaEWFgsvsplDDPVLKDLAK 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489016068 214 KYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19112 238 KYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSL 290
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
9-264 |
2.25e-63 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 200.80 E-value: 2.25e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK---DSG-IPREELFITTKLWNDIHTYEE 84
Cdd:cd19111 1 GFPMPVIGLGTYQSP-PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKwwlKNGkLKREEVFITTKLPPVYLEFKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 85 AQEAFAASMERLGLDYLDLYLIHWP------NPKPLRENNAWKKrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLE 158
Cdd:cd19111 80 TEKSLEKSLENLKLPYVDLYLIHHPcgfvnkKDKGERELASSDV--TSVWRAMEALVSEGKVKSIGLSNFNPRQINKILA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 159 TARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG------------QGELFQNPAVQAVADKYGKTIAQVALAW 226
Cdd:cd19111 158 YAKVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGspgranqslwpdQPDLLEDPTVLAIAKELDKTPAQVLLRF 237
|
250 260 270
....*....|....*....|....*....|....*...
gi 489016068 227 SLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVLK 264
Cdd:cd19111 238 VLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLK 275
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
8-261 |
3.87e-63 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 199.80 E-value: 3.87e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTW-KAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK---DSG--IPREELFITTKLWNDIHT 81
Cdd:cd19124 1 SGQTMPVIGMGTAsDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAealRLGlvKSRDELFVTSKLWCSDAH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWP-NPKPLRENNAWKKRNA------EVWRAMEALYNLGKIRAIGVSNFLPHHLE 154
Cdd:cd19124 81 PDLVLPALKKSLRNLQLEYVDLYLIHWPvSLKPGKFSFPIEEEDFlpfdikGVWEAMEECQRLGLTKAIGVSNFSCKKLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 ALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG-------ELFQNPAVQAVADKYGKTIAQVALAWS 227
Cdd:cd19124 161 ELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPgtkwgsnAVMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270
....*....|....*....|....*....|....
gi 489016068 228 LQEGFLPLPKSVTPSRIASNLDCFDIELDDADLE 261
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLE 274
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
7-249 |
7.97e-62 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 197.29 E-value: 7.97e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTWkAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKD----SGIPREELFITTKLWNDIHTY 82
Cdd:cd19129 1 NGSGAIPALGFGTL-IPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 83 EEAQEAFAASMERLGLDYLDLYLIHWP---------NPKPLRENNAWKK--RNAEVWRAMEALYNLGKIRAIGVSNFLPH 151
Cdd:cd19129 80 ERVKPAFEASLKRLQLDYLDLYLIHTPfafqpgdeqDPRDANGNVIYDDgvTLLDTWRAMERLVDEGRCKAIGLSDVSLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 152 HLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG---ELFQNPAVQAVADKYGKTIAQVALAWSL 228
Cdd:cd19129 160 KLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGmepKLLEDPVITAIARRVNKTPAQVLLAWAI 239
|
250 260
....*....|....*....|.
gi 489016068 229 QEGFLPLPKSVTPSRIASNLD 249
Cdd:cd19129 240 QRGTALLTTSKTPSRIRENFD 260
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
5-263 |
1.51e-60 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 194.28 E-value: 1.51e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGTWKAQDgEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK---DSG-IPREELFITTKLWNDIH 80
Cdd:cd19155 5 TFNNGEKMPVVGLGTWQSSP-EEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKkwiDSGkVKREELFIVTKLPPGGN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRE-NNAWKKRNAEV-----------WRAMEALYNLGKIRAIGVSNF 148
Cdd:cd19155 84 RREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLSKEdDSGKLDPTGEHkqdyttdlldiWKAMEAQVDQGLTRSIGLSNF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 149 LPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQ-----------------GELFQNPAVQAV 211
Cdd:cd19155 164 NREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSpgaahfspgtgspsgssPDLLQDPVVKAI 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489016068 212 ADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19155 244 AERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKL 295
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
6-263 |
1.18e-59 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 191.56 E-value: 1.18e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWK-AQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK----DSGIPREELFITTKLWNDIh 80
Cdd:cd19119 6 LNTGASIPALGLGTASpHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKraidDGSIKREELFITTKVWPTF- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 tYEEAQEAFAASMERLGLDYLDLYLIHWP---------NPKPLR-ENNAWKKRNA------EVWRAMEALYNLGKIRAIG 144
Cdd:cd19119 85 -YDEVERSLDESLKALGLDYVDLLLVHWPvcfekdsddSGKPFTpVNDDGKTRYAasgdhiTTYKQLEKIYLDGRAKAIG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 145 VSNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG--QGELFQNPAVQAVADKYGKTIAQV 222
Cdd:cd19119 164 VSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGshGAPNLKNPLVKKIAEKYNVSTGDI 243
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489016068 223 ALAWSLQEGFLPLPKSVTPSRIASNLDCfdIELDDADLEVL 263
Cdd:cd19119 244 LISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKL 282
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
13-266 |
1.56e-59 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 190.81 E-value: 1.56e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGTWKAQDgEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAI----KDSGIPREELFITTKLWNDIHTYEEAQEA 88
Cdd:cd19128 2 PRLGFGTYKITE-SESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFseifKDGGVKREDLFITSKLWPTMHQPENVKEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 89 FAASMERLGLDYLDLYLIHWP------NPKPLRENNAW----KKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLE 158
Cdd:cd19128 81 LLITLQDLQLEYLDLFLIHWPlafdmdTDGDPRDDNQIqslsKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 159 TARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG-----QGELFQN-PAVQAVADKYGKTIAQVALAWSLQE-- 230
Cdd:cd19128 161 YCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGgsygdGNLTFLNdSELKALATKYNTTPPQVIIAWHLQKwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 489016068 231 -GFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19128 241 kNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
12-264 |
3.35e-59 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 189.36 E-value: 3.35e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWK--------AQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKdsGIPREELFITTKLWNDIH 80
Cdd:cd19072 4 VPVLGLGTWGigggmskdYSDDKKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIK--GFDREDLFITTKVSPDHL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWPNPK-PLRennawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLET 159
Cdd:cd19072 82 KYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSiPIE----------ETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 160 ARMTP-AVNQIRLapGVYQTEAVN----FCREHEILLEAWGPFGQGEL---FQNPAVQAVADKYGKTIAQVALAWSL-QE 230
Cdd:cd19072 152 LKKGPiVANQVEY--NLFDREEESgllpYCQKNGIAIIAYSPLEKGKLsnaKGSPLLDEIAKKYGKTPAQIALNWLIsKP 229
|
250 260 270
....*....|....*....|....*....|....
gi 489016068 231 GFLPLPKSVTPSRIASNLDCFDIELDDADLEVLK 264
Cdd:cd19072 230 NVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
9-263 |
4.93e-58 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 187.77 E-value: 4.93e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWK--AQDGEEA-YQAtlaaLKAGYRHIDTAAIYKNEESVGR----AIKDSGIPREELFITTKLWNDIHT 81
Cdd:cd19114 1 GDKMPLVGFGTAKikANETEEViYNA----IKVGYRLIDGALLYGNEAEVGRgirkAIQEGLVKREDLFIVTKLWNNFHG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWPNPKPL---REN--NAWKKRNA-----------EVWRAMEALYNLGKIRAIGV 145
Cdd:cd19114 77 KDHVREAFDRQLKDYGLDYIDLYLIHFPIPAAYvdpAENypFLWKDKELkkfpleqspmqECWREMEKLVDAGLVRNIGI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 146 SNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG-------------ELFQNPAVQAVA 212
Cdd:cd19114 157 ANFNVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAvytkvtkhlkhftNLLEHPVVKKLA 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489016068 213 DKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19114 237 DKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEAL 287
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
5-263 |
8.18e-58 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 187.24 E-value: 8.18e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGTWKAQDGEEAYQaTLAALKAGYRHIDTAAIYKNE----ESVGRAIKDSGIPREELFITTKLWNDIH 80
Cdd:cd19115 6 KLNSGYDMPLVGFGLWKVNNDTCADQ-VYNAIKAGYRLFDGACDYGNEveagQGVARAIKEGIVKREDLFIVSKLWNTFH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWP------NPKpLRENNAWKKRNAEV----------WRAMEALYNLGKIRAIG 144
Cdd:cd19115 85 DGERVEPICRKQLADWGIDYFDLFLIHFPialkyvDPA-VRYPPGWFYDGKKVefsnapiqetWTAMEKLVDKGLARSIG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 145 VSNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG-QG-------------ELFQNPAVQA 210
Cdd:cd19115 164 VSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGpQSfleldlpgakdtpPLFEHDVIKS 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489016068 211 VADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19115 244 IAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAI 296
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
9-263 |
2.42e-57 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 186.08 E-value: 2.42e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAI----KDSGIPREELFITTKLWNDIHTYEE 84
Cdd:cd19107 1 GAKMPILGLGTWKSPPGQ-VTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIqekiKEQVVKREDLFIVSKLWCTFHEKGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 85 AQEAFAASMERLGLDYLDLYLIHWP-------NPKPLRENNAW---KKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLE 154
Cdd:cd19107 80 VKGACQKTLSDLKLDYLDLYLIHWPtgfkpgkELFPLDESGNVipsDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 ALLETA--RMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGE----------LFQNPAVQAVADKYGKTIAQV 222
Cdd:cd19107 160 RILNKPglKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDrpwakpedpsLLEDPKIKEIAAKHNKTTAQV 239
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489016068 223 ALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19107 240 LIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATI 280
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
12-261 |
3.60e-56 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 181.76 E-value: 3.60e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQdGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIKDSGIPREELFITTKLWNDIHTYEEAQEAFAA 91
Cdd:PRK11172 3 IPAFGLGTFRLK-DQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIPSLKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 92 SMERLGLDYLDLYLIHWPNPK---PLREnnawkkrnaevwrAMEALY---NLGKIRAIGVSNF-LPHHLEALLETARMTP 164
Cdd:PRK11172 82 SLQKLRTDYVDLTLIHWPSPNdevSVEE-------------FMQALLeakKQGLTREIGISNFtIALMKQAIAAVGAENI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 165 AVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRI 244
Cdd:PRK11172 149 ATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENL 228
|
250
....*....|....*..
gi 489016068 245 ASNLDCFDIELDDADLE 261
Cdd:PRK11172 229 ASNLLAQDLQLDAEDMA 245
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
12-263 |
1.13e-55 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 181.70 E-value: 1.13e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQDGEeAYQATLAALKAGYRHIDTAAIYKNEESVGRAI----KDSGIPREELFITTKLWNDIHTYEEAQE 87
Cdd:cd19110 4 IPAVGLGTWKASPGE-VTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIrekiKEGVVRREDLFIVSKLWCTCHKKSLVKT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 88 AFAASMERLGLDYLDLYLIHWP---NPK----PLRENNAWKKRNA---EVWRAMEALYNLGKIRAIGVSNFLPHHLEALL 157
Cdd:cd19110 83 ACTRSLKALKLNYLDLYLIHWPmgfKPGepdlPLDRSGMVIPSDTdflDTWEAMEDLVIEGLVKNIGVSNFNHEQLERLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 158 ETA--RMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQG----ELFQNPAVQAVADKYGKTIAQVALAWSLQEG 231
Cdd:cd19110 163 NKPglRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGScegvDLIDDPVIQRIAKKHGKSPAQILIRFQIQRN 242
|
250 260 270
....*....|....*....|....*....|..
gi 489016068 232 FLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19110 243 VIVIPKSVTPSRIKENIQVFDFELTEHDMDNL 274
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
6-261 |
3.00e-54 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 178.02 E-value: 3.00e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAqDGEEAYQATLAALKAGYRHIDTAAIYKNEESVG----RAIKDSGIPREELFITTKLWNDIHT 81
Cdd:cd19113 5 LNSGYKMPSVGFGCWKL-DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGegvnRAIDEGLVKREELFLTSKLWNNFHD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWP---NPKPLRE----------NNAWKKRN---AEVWRAMEALYNLGKIRAIGV 145
Cdd:cd19113 84 PKNVETALNKTLSDLKLDYVDLFLIHFPiafKFVPIEEkyppgfycgdGDNFVYEDvpiLDTWKALEKLVDAGKIKSIGV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 146 SNFLPHHLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG--------QGE------LFQNPAVQAV 211
Cdd:cd19113 164 SNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGpqsfvelnQGRalntptLFEHDTIKSI 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489016068 212 ADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLE 261
Cdd:cd19113 244 AAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFE 293
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
6-263 |
3.09e-53 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 175.11 E-value: 3.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTWKAQD--GEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAI----KDSGIPREELFITTKLWNDI 79
Cdd:cd19108 5 LNDGHFIPVLGFGTYAPEEvpKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIrskiADGTVKREDIFYTSKLWCTF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKRNAEV----------WRAMEALYNLGKIRAIGVSNFL 149
Cdd:cd19108 85 HRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLifdtvdlcatWEAMEKCKDAGLAKSIGVSNFN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 150 PHHLEALLETA--RMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFG-QGE----------LFQNPAVQAVADKYG 216
Cdd:cd19108 165 RRQLEMILNKPglKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGsQRDkewvdqnspvLLEDPVLCALAKKHK 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489016068 217 KTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19108 245 RTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKAL 291
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
6-263 |
5.43e-49 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 163.19 E-value: 5.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 6 LNNGVGIPVLGFGTW----KAQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKDSgipREELFITTKLWND 78
Cdd:cd19138 5 LPDGTKVPALGQGTWymgeDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSKVLPS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 79 IHTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLE 158
Cdd:cd19138 82 NASRQGTVRACERSLRRLGTDYLDLYLLHWRGGVPL----------AETVAAMEELKKEGKIRAWGVSNFDTDDMEELWA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 159 TARMTP-AVNQIR--LAPGVYQTEAVNFCREHEILLEAWGPFGQGE-----LFQNPAVQAVADKYGKTIAQVALAWSL-Q 229
Cdd:cd19138 152 VPGGGNcAANQVLynLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGllrrgLLENPTLKEIAARHGATPAQVALAWVLrD 231
|
250 260 270
....*....|....*....|....*....|....
gi 489016068 230 EGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19138 232 GNVIAIPKSGSPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
9-263 |
9.46e-49 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 162.35 E-value: 9.46e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWK---------AQDgEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDsgIPREELFITTKLW 76
Cdd:cd19137 1 GEKIPALGLGTWGiggfltpdySRD-EEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD--FPREDLFIVTKVW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 NDIHTYEEAQEAFAASMERLGLDYLDLYLIHWPNPK-PLRENnawkkrnaevWRAMEALYNLGKIRAIGVSNFLPHHLEA 155
Cdd:cd19137 78 PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNiPLEET----------LSAMAEGVRQGLIRYIGVSNFNRRLLEE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 156 LLETARMTPAVNQIR--LAPGVYQTEAV-NFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQ-EG 231
Cdd:cd19137 148 AISKSQTPIVCNQVKynLEDRDPERDGLlEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQkPN 227
|
250 260 270
....*....|....*....|....*....|..
gi 489016068 232 FLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19137 228 VVAIPKAGRVEHLKENLKATEIKLSEEEMKLL 259
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
15-266 |
1.15e-48 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 162.87 E-value: 1.15e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 15 LGFGTW------KAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTKLWNDI------ 79
Cdd:pfam00248 1 IGLGTWqlgggwGPISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVPDGDgpwpsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLET 159
Cdd:pfam00248 81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIE---------ETWDALEELKKEGKIRAIGVSNFDAEQIEKALTK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 160 ARMTPAVNQIR--LAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQ---------------------------NPAVQA 210
Cdd:pfam00248 152 GKIPIVAVQVEynLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGkytrdpdkgpgerrrllkkgtplnleaLEALEE 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 211 VADKYGKTIAQVALAWSLQE--GFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:pfam00248 232 IAKEHGVSPAQVALRWALSKpgVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
9-266 |
1.29e-48 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 163.43 E-value: 1.29e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTW---KAQDGEEAYQATLAALKAGYRHIDTAAIYKNEESVGRAIK----DSGIPREELFITTKLWNDIHT 81
Cdd:cd19109 1 GNSIPIIGLGTYsepKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIRekiaEGKVKREDIFYCGKLWNTCHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWP---NPK----PLRENNAWKKRNAEV---WRAMEALYNLGKIRAIGVSNFLPH 151
Cdd:cd19109 81 PELVRPTLERTLKVLQLDYVDLYIIEMPmafKPGdeiyPRDENGKWLYHKTNLcatWEALEACKDAGLVKSIGVSNFNRR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 152 HLEALLETA--RMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGE-----------LFQNPAVQAVADKYGKT 218
Cdd:cd19109 161 QLELILNKPglKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRdpiwvnvssppLLEDPLLNSIGKKYNKT 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489016068 219 IAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL----KNV 266
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIealnKNV 292
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
12-267 |
2.48e-42 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 146.58 E-value: 2.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTW--------KAQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKDsgiPREELFITTKLWNDIH 80
Cdd:cd19085 1 VSRLGLGCWqfgggywwGDQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKG---RRDDVVIATKVSPDNL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWPNPK-PLRENNAwkkrnaevwrAMEALYNLGKIRAIGVSNFLPHHLEALLET 159
Cdd:cd19085 78 TPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDvPLEETME----------ALEKLKEEGKIRAIGVSNFGPAQLEEALDA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 160 ARMTpaVNQI------RlapgVYQTEAVNFCREHEILLEAWGPFGQG-------------------------------EL 202
Cdd:cd19085 148 GRID--SNQLpynllwR----AIEYEILPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdartrlfrhfepgaeeET 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489016068 203 FQN-PAVQAVADKYGKTIAQVALAWSLQEGFLPlpkSV-----TPSRIASNLDCFDIELDDADLEVLKNVS 267
Cdd:cd19085 222 FEAlEKLKEIADELGVTMAQLALAWVLQQPGVT---SVivgarNPEQLEENAAAVDLELSPSVLERLDEIS 289
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
7-267 |
1.18e-39 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 140.31 E-value: 1.18e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTW-----KAQDGEEAYQATL-AALKAGYRHIDTAAIY---KNEESVGRAIKDSgiPREELFITTKLWN 77
Cdd:COG0667 8 RSGLKVSRLGLGTMtfggpWGGVDEAEAIAILdAALDAGINFFDTADVYgpgRSEELLGEALKGR--PRDDVVIATKVGR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 78 DI--------HTYEEAQEAFAASMERlgldyldlyLIHWPNPK-PLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNF 148
Cdd:COG0667 86 RMgpgpngrgLSREHIRRAVEASLRRlgtdyidlyQLHRPDPDtPI----------EETLGALDELVREGKIRYIGVSNY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 149 LPHHLEALLETARMTP--AVNQIR---LAPGVyQTEAVNFCREHEILLEAWGPFGQGEL-------------------FQ 204
Cdd:COG0667 156 SAEQLRRALAIAEGLPpiVAVQNEyslLDRSA-EEELLPAARELGVGVLAYSPLAGGLLtgkyrrgatfpegdraatnFV 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489016068 205 NP-----------AVQAVADKYGKTIAQVALAWSLQEGF--LPLPKSVTPSRIASNLDCFDIELDDADLEVLKNVS 267
Cdd:COG0667 235 QGylternlalvdALRAIAAEHGVTPAQLALAWLLAQPGvtSVIPGARSPEQLEENLAAADLELSAEDLAALDAAL 310
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-263 |
2.69e-38 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 136.20 E-value: 2.69e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKAQDG----------EEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGiPREELFITTKLWND 78
Cdd:cd19093 2 VSPLGLGTWQWGDRlwwgygeygdEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKELG-DRDEVVIATKFAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 79 IHTYEEAQ--EAFAASMERLGLDYLDLYLIHWPNPkplrennaWKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLE-- 154
Cdd:cd19093 81 PWRLTRRSvvKALKASLERLGLDSIDLYQLHWPGP--------WYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRra 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 -ALLETARMTPAVNQIR---LAPGVYQTEAVNFCREHEILLEAWGPFGQGEL-------------------FQN-----P 206
Cdd:cd19093 153 hKALKERGVPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAQGLLtgkyspenpppggrrrlfgRKNlekvqP 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 207 ---AVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19093 233 lldALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAEL 292
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
12-263 |
4.18e-34 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 125.33 E-value: 4.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTW-------KAQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKDSgipREELFITTK---LWND 78
Cdd:cd19084 4 VSRIGLGTWaiggtwwGEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR---RDDVVIATKcglRWDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 79 IH------TYEEAQEAFAASMERLGLDYLDLYLIHWPNPK-PLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPH 151
Cdd:cd19084 81 GKgvtkdlSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNtPI----------EETAEALEKLKKEGKIRYIGVSNFSVE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 152 HLEALLETARmtPAVNQIR---LAPGVYQtEAVNFCREHEILLEAWGPFGQGEL---------------------FQNP- 206
Cdd:cd19084 151 QLEEARKYGP--IVSLQPPysmLEREIEE-ELLPYCRENGIGVLPYGPLAQGLLtgkykkeptfppddrrsrfpfFRGEn 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 207 ---------AVQAVADKYGKTIAQVALAWSLQEGFL--PLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19084 228 feknleivdKLKEIAEKYGKSLAQLAIAWTLAQPGVtsAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
13-249 |
2.02e-33 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 121.86 E-value: 2.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGTWK---AQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIpREELFITTKLWNDIHTYEEAQ 86
Cdd:cd06660 1 SRLGLGTMTfggDGDEEEAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGN-RDDVVIATKGGHPPGGDPSRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 87 --------EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLE 158
Cdd:cd06660 80 rlspehirRDLEESLRRLGTDYIDLYYLHRDDPSTPVE---------ETLEALNELVREGKIRYIGVSNWSAERLAEALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 159 TAR----MTPAVNQIR---LAPGVYQTEAVNFCREHEILLEAWGPFGQGelfqnpavqavadkygktIAQVALAWSLQ-- 229
Cdd:cd06660 151 YAKahglPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSqp 212
|
250 260
....*....|....*....|
gi 489016068 230 EGFLPLPKSVTPSRIASNLD 249
Cdd:cd06660 213 FVTVPIVGARSPEQLEENLA 232
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
7-256 |
2.51e-33 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 123.05 E-value: 2.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTWKAQDG----EEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTK----L 75
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWgesaEELLSLIEAALELGITTFDHADIYgggKCEELFGEALALNPGLREKIEIQTKcgirL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 WNDIH---------TYEEAQEAFAASMERLGLDYLDLYLIHwpNPKPLREnnAWkkrnaEVWRAMEALYNLGKIRAIGVS 146
Cdd:cd19092 81 GDDPRpgrikhydtSKEHILASVEGSLKRLGTDYLDLLLLH--RPDPLMD--PE-----EVAEAFDELVKSGKVRYFGVS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 147 NFLPHHLEALleTARMTP--AVNQIRLapGVYQTEAV-----NFCREHEILLEAWGPFGQGELFQNP---------AVQA 210
Cdd:cd19092 152 NFTPSQIELL--QSYLDQplVTNQIEL--SLLHTEAIddgtlDYCQLLDITPMAWSPLGGGRLFGGFderfqrlraALEE 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 489016068 211 VADKYGKTIAQVALAWSLQE--GFLPLPKSVTPSRIASNLDCFDIELD 256
Cdd:cd19092 228 LAEEYGVTIEAIALAWLLRHpaRIQPILGTTNPERIRSAVKALDIELT 275
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
2-259 |
3.23e-33 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 122.95 E-value: 3.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 2 REYLLNNGVGIPVLGFGTWKAQDGEEAYQATL----AALKAGYRHIDTAAIYKN---EESVGRAIKDSGIPREELFITTK 74
Cdd:COG4989 3 RIKLGASGLSVSRIVLGCMRLGEWDLSPAEAAalieAALELGITTFDHADIYGGytcEALFGEALKLSPSLREKIELQTK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 ---------LWNDIHTYEEAQEAFAASMERlgldy----ldlyLIHwpNPKPLREnnawkkrNAEVWRAMEALYNLGKIR 141
Cdd:COG4989 83 cgirlpseaRDNRVKHYDTSKEHIIASVEGslrrlgtdyldllLLH--RPDPLMD-------PEEVAEAFDELKASGKVR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 142 AIGVSNFLPHHLEaLLETARMTP-AVNQIRLapGVYQTEAVN-----FCREHEILLEAWGPFGQGELFQ---------NP 206
Cdd:COG4989 154 HFGVSNFTPSQFE-LLQSALDQPlVTNQIEL--SLLHTDAFDdgtldYCQLNGITPMAWSPLAGGRLFGgfdeqfprlRA 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 489016068 207 AVQAVADKYGKTIAQVALAWSLQ--EGFLPLPKSVTPSRIASNLDCFDIELDDAD 259
Cdd:COG4989 231 ALDELAEKYGVSPEAIALAWLLRhpAGIQPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-263 |
2.06e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 107.76 E-value: 2.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTWKA-----------QDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSgipREELFITTK--- 74
Cdd:cd19102 1 LTTIGLGTWAIggggwgggwgpQDDRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL---RDRPIVATKcgl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 LWND----IHTYEEAQ--EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNF 148
Cdd:cd19102 78 LWDEegriRRSLKPASirAECEASLRRLGVDVIDLYQIHWPDPDEPIE---------EAWGALAELKEEGKVRAIGVSNF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 149 LPHHLEALLETARMtpAVNQIR---LAPGVyQTEAVNFCREHEILLEAWGPFGQGEL----------------------- 202
Cdd:cd19102 149 SVDQMKRCQAIHPI--ASLQPPyslLRRGI-EAEILPFCAEHGIGVIVYSPMQSGLLtgkmtpervaslpaddwrrrspf 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489016068 203 FQNP----------AVQAVADKYGKTIAQVALAWSLQegfLP-----LPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19102 226 FQEPnlarnlalvdALRPIAERHGRTVAQLAIAWVLR---RPevtsaIVGARRPDQIDETVGAADLRLTPEELAEI 298
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
7-260 |
9.62e-27 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 106.20 E-value: 9.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTW--------KAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSgipREELFITTK- 74
Cdd:cd19149 6 KSGIEASVIGLGTWaigggpwwGGSDDNESIRTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKGR---RDKVVLATKc 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 --LWN-------------DIHTY---EEAQEAFAASMERLGLDYLDLYLIHWP-NPKPLrennawkkrnAEVWRAMEALY 135
Cdd:cd19149 83 glRWDreggsfffvrdgvTVYKNlspESIREEVEQSLKRLGTDYIDLYQTHWQdVETPI----------EETMEALEELK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 136 NLGKIRAIGVSNFLPHHLEALLETArmTPAVNQIR---LAPGVyQTEAVNFCREHEILLEAWGPFGQG------------ 200
Cdd:cd19149 153 RQGKIRAIGASNVSVEQIKEYVKAG--QLDIIQEKysmLDRGI-EKELLPYCKKNNIAFQAYSPLEQGlltgkitpdref 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 201 ---------ELFQNPAVQAV----------ADKYGKTIAQVALAWSLQEGFLP--LPKSVTPSRIASNLDCFDIELDDAD 259
Cdd:cd19149 230 dagdarsgiPWFSPENREKVlallekwkplCEKYGCTLAQLVIAWTLAQPGITsaLCGARKPEQAEENAKAGDIRLSAED 309
|
.
gi 489016068 260 L 260
Cdd:cd19149 310 I 310
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
4-267 |
3.28e-23 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 96.53 E-value: 3.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 4 YLLNNGVGIPVLGFGT------------WKAQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKDSgipREE 68
Cdd:cd19091 5 TLGRSGLKVSELALGTmtfgggggffgaWGGVDQEEADRLVDIALDAGINFFDTADVYSEgesEEILGKALKGR---RDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 69 LFITTKLW-------NDI-----HTYEEAQeafaASMERLGLDYLDLYLIHWPNPK-PLrennawkkrnAEVWRAMEALY 135
Cdd:cd19091 82 VLIATKVRgrmgegpNDVglsrhHIIRAVE----ASLKRLGTDYIDLYQLHGFDALtPL----------EETLRALDDLV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 136 NLGKIRAIGVSNFLPHHLEALLETARM----TPAVNQI--RLAPGVYQTEAVNFCREHEILLEAWGPFGQGEL------- 202
Cdd:cd19091 148 RQGKVRYIGVSNFSAWQIMKALGISERrglaRFVALQAyySLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLsgkyrrg 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 203 -------------FQNP------------AVQAVADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFD 252
Cdd:cd19091 228 qpapegsrlrrtgFDFPpvdrergydvvdALREIAKETGATPAQVALAWLLSR---PTVSSViigarNEEQLEDNLGAAG 304
|
330
....*....|....*
gi 489016068 253 IELDDADLEVLKNVS 267
Cdd:cd19091 305 LSLTPEEIARLDKVS 319
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
12-256 |
4.20e-23 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 94.98 E-value: 4.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGT--------WKAQDGEEAYQATL-AALKAGYRHIDTAAIY---KNEESVGRAIKDSGiprEELFITTKL---- 75
Cdd:cd19088 1 VSRLGYGAmrltgpgiWGPPADREEAIAVLrRALELGVNFIDTADSYgpdVNERLIAEALHPYP---DDVVIATKGglvr 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 -----WNDIHTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLP 150
Cdd:cd19088 78 tgpgwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFE---------EQLGALAELQDEGLIRHIGLSNVTV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 151 HHLEALLETARMTpAVnQIRLAPGVYQTEAV-NFCREHEILLEAWGPFGQGELFQN-PAVQAVADKYGKTIAQVALAWSL 228
Cdd:cd19088 149 AQIEEARAIVRIV-SV-QNRYNLANRDDEGVlDYCEAAGIAFIPWFPLGGGDLAQPgGLLAEVAARLGATPAQVALAWLL 226
|
250 260 270
....*....|....*....|....*....|
gi 489016068 229 Q--EGFLPLPKSVTPSRIASNLDCFDIELD 256
Cdd:cd19088 227 ArsPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
9-231 |
4.37e-23 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 95.84 E-value: 4.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGiPREELFITTKL---WNDIHTY 82
Cdd:cd19148 8 ALGTWAIGGWMWGGTDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYG-KRDRVVIATKVgleWDEGGEV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 83 ------EEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAwkkrnaevwRAMEALYNLGKIRAIGVSNFLPHHLEAL 156
Cdd:cd19148 87 vrnsspARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETA---------EALKELLDEGKIRAIGVSNFSPEQMETF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 157 LETARMtpAVNQIR--LAPGVYQTEAVNFCREHEILLEAWGPFGQGEL---------------------FQNPA----VQ 209
Cdd:cd19148 158 RKVAPL--HTVQPPynLFEREIEKDVLPYARKHNIVTLAYGALCRGLLsgkmtkdtkfegddlrrtdpkFQEPRfsqyLA 235
|
250 260
....*....|....*....|....*....
gi 489016068 210 AV-------ADKYGKTIAQVALAWSLQEG 231
Cdd:cd19148 236 AVeeldklaQERYGKSVIHLAVRWLLDQP 264
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
35-263 |
6.09e-21 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 90.34 E-value: 6.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 35 ALKAGYRHIDTAAIYKN---EESVGRAIKDSgIPREELFITTKLWNDIHTYEEAQ--------EAFAASMERLGLDYLDL 103
Cdd:cd19079 44 ALDLGINFFDTANVYSGgasEEILGRALKEF-APRDEVVIATKVYFPMGDGPNGRglsrkhimAEVDASLKRLGTDYIDL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 104 YLIHWPNPK-PLREnnawkkrnaevwrAMEALYNL---GKIRAIGVSNFLPHHLEALLETARM---TPAV---NQIRLap 173
Cdd:cd19079 123 YQIHRWDYEtPIEE-------------TLEALHDVvksGKVRYIGASSMYAWQFAKALHLAEKngwTKFVsmqNHYNL-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 174 gVYQ---TEAVNFCREHEILLEAWGPFGQGELFQNP------------------------------AVQAVADKYGKTIA 220
Cdd:cd19079 188 -LYReeeREMIPLCEEEGIGVIPWSPLARGRLARPWgdtterrrsttdtaklkydyfteadkeivdRVEEVAKERGVSMA 266
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 489016068 221 QVALAWSLQEG--FLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19079 267 QVALAWLLSKPgvTAPIVGATKLEHLEDAVAALDIKLSEEEIKYL 311
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
9-257 |
2.32e-20 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 88.42 E-value: 2.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTW---KAQDGEEAYQATL-AALKAGYRHIDTAAIYKN---EESVGRAIKdsGIPREELFITTKL-W---- 76
Cdd:cd19074 1 GLKVSELSLGTWltfGGQVDDEDAKACVrKAYDLGINFFDTADVYAAgqaEEVLGKALK--GWPRESYVISTKVfWptgp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 --ND-------IHtyeeaqEAFAASMERLGLDYLDLYLIHWPNPK-PLRennawkkrnaEVWRAMEALYNLGKIRAIGVS 146
Cdd:cd19074 79 gpNDrglsrkhIF------ESIHASLKRLQLDYVDIYYCHRYDPEtPLE----------ETVRAMDDLIRQGKILYWGTS 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 147 NFLPHHLEALLETAR----MTPAVNQIRLApgVYQTEAVN----FCREHEILLEAWGPFGQG------------------ 200
Cdd:cd19074 143 EWSAEQIAEAHDLARqfglIPPVVEQPQYN--MLWREIEEevipLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsra 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 201 ----------ELFQNPAVQAV------ADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFDIELDD 257
Cdd:cd19074 221 tdednrdkkrRLLTDENLEKVkklkpiADELGLTLAQLALAWCLRN---PAVSSAiigasRPEQLEENVKASGVKLSP 295
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
5-261 |
2.83e-20 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 88.04 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGT------WKAQDGEEAyQATL-AALKAGYRHIDTAAIY---KNEESVGRAIKDsgiPREELFITTK 74
Cdd:cd19076 5 LGTQGLEVSALGLGCmgmsafYGPADEEES-IATLhRALELGVTFLDTADMYgpgTNEELLGKALKD---RRDEVVIATK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 ---LWNDIHTY-------EEAQEAFAASMERLGLDYLDLYLIHWPNPK-PLrennawkkrnAEVWRAMEALYNLGKIRAI 143
Cdd:cd19076 81 fgiVRDPGSGFrgvdgrpEYVRAACEASLKRLGTDVIDLYYQHRVDPNvPI----------EETVGAMAELVEEGKVRYI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 144 GVSnflphhlEAlletarmtpAVNQIRLAPGVY-----QTE-----------AVNFCREHEILLEAWGPFG--------- 198
Cdd:cd19076 151 GLS-------EA---------SADTIRRAHAVHpitavQSEyslwtrdiedeVLPTCRELGIGFVAYSPLGrgfltgaik 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 199 -----------------QGELFQN-----PAVQAVADKYGKTIAQVALAWSLQEG--FLPLPKSVTPSRIASNLDCFDIE 254
Cdd:cd19076 215 spedlpeddfrrnnprfQGENFDKnlklvEKLEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYLEENVGALDVV 294
|
....*..
gi 489016068 255 LDDADLE 261
Cdd:cd19076 295 LTPEELA 301
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
7-266 |
6.39e-20 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 87.95 E-value: 6.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTWKAQ--DGEEAYQATLAALKAGYRHIDTAAIY-KNEESVGRAIKDsgiPREELFITTKLWNDIHTYE 83
Cdd:COG1453 8 KTGLEVSVLGFGGMRLPrkDEEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKG---PRDKVILATKLPPWVRDPE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 84 EAQEAFAASMERLGLDYLDLYLIHWPNpkplrENNAWKK--RNAEVWRAMEALYNLGKIRAIGVSNflpHH-LEALLETA 160
Cdd:COG1453 85 DMRKDLEESLKRLQTDYIDLYLIHGLN-----TEEDLEKvlKPGGALEALEKAKAEGKIRHIGFST---HGsLEVIKEAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 161 R-------MTP--AVNQiRLAPGvyqTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKYGKTIAQVAL--AWSLQ 229
Cdd:COG1453 157 DtgdfdfvQLQynYLDQ-DNQAG---EEALEAAAEKGIGVIIMKPLKGGRLANPPEKLVELLCPPLSPAEWALrfLLSHP 232
|
250 260 270
....*....|....*....|....*....|....*....
gi 489016068 230 EGFLPLPKSVTPSRIASNLDCFD--IELDDADLEVLKNV 266
Cdd:COG1453 233 EVTTVLSGMSTPEQLDENLKTADnlEPLTEEELAILERL 271
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
4-263 |
6.91e-19 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 84.57 E-value: 6.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 4 YLLNNGVGIPVLGFGTWkaQDGEEAYQATLAAL-----KAGYRHIDTAAIY----------KNEESVGRAIKDSGiPREE 68
Cdd:cd19081 1 PLGRTGLSVSPLCLGTM--VFGWTADEETSFALldafvDAGGNFIDTADVYsawvpgnaggESETIIGRWLKSRG-KRDR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 69 LFITTKLWNDI----------HTyeeaQEAFAASMERLGLDYLDLYLIHWPNPK-PLREnnawkkrnaevwrAMEALYNL 137
Cdd:cd19081 78 VVIATKVGFPMgpngpglsrkHI----RRAVEASLRRLQTDYIDLYQAHWDDPAtPLEE-------------TLGALNDL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 138 ---GKIRAIGVSNFLPHHLEALLETARMTPAVNQIRLAP-------GVYQTEAVNFCREHEILLEAWGPFGQGEL----- 202
Cdd:cd19081 141 irqGKVRYIGASNYSAWRLQEALELSRQHGLPRYVSLQPeynlvdrESFEGELLPLCREEGIGVIPYSPLAGGFLtgkyr 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 203 -----------------FQNP-------AVQAVADKYGKTIAQVALAWSLQEGFL--PLPKSVTPSRIASNLDCFDIELD 256
Cdd:cd19081 221 seadlpgstrrgeaakrYLNErglrildALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLRLT 300
|
....*..
gi 489016068 257 DADLEVL 263
Cdd:cd19081 301 DEEVARL 307
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
15-266 |
2.46e-18 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 82.85 E-value: 2.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 15 LGFGT--------WKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGipREELFITTKLWNDIHTYE 83
Cdd:cd19083 14 IGLGTnavgghnlYPNLDEEEGKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLKEYN--RNEVVIATKGAHKFGGDG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 84 EA--------QEAFAASMERLGLDYLDLYLIHWPNPKPLRennawkkrnAEVWRAMEALYNLGKIRAIGVSNFlphHLEA 155
Cdd:cd19083 92 SVlnnspeflRSAVEKSLKRLNTDYIDLYYIHFPDGETPK---------AEAVGALQELKDEGKIRAIGVSNF---SLEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 156 LLEtARMTPAVNQIRLAPGVYQTEAVN----FCREHEILLEAWGPFGQG---------------------ELFQNPAVQA 210
Cdd:cd19083 160 LKE-ANKDGYVDVLQGEYNLLQREAEEdilpYCVENNISFIPYFPLASGllagkytkdtkfpdndlrndkPLFKGERFSE 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 211 ----------VADKYGKTIAQVALAWSLQEGFLP--LPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19083 239 nldkvdklksIADEKGVTVAHLALAWYLTRPAIDvvIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
13-252 |
6.36e-18 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 81.07 E-value: 6.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGT------WKAQDGEEAYQATL-AALKAGYRHIDTAAIY---KNEESVGRAIKDsgIPREELFITTKL-WNDIHT 81
Cdd:cd19096 1 SVLGFGTmrlpesDDDSIDEEKAIEMIrYAIDAGINYFDTAYGYgggKSEEILGEALKE--GPREKFYLATKLpPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHWPNpkplRENNAWKKRNAEVWRAMEALYNLGKIRAIGVSnFlphH-----LEAL 156
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLN----SPEWLEKARKGGLLEFLEKAKKEGLIRHIGFS-F---HdspelLKEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 157 LETARMtpAVNQIRL----APGVYQTEAVNFCREHEILLEAWGPFGQGELFQNP-AVQAVADKYGKTIAQVAL--AWSLQ 229
Cdd:cd19096 151 LDSYDF--DFVQLQYnyldQENQAGRPGIEYAAKKGMGVIIMEPLKGGGLANNPpEALAILCGAPLSPAEWALrfLLSHP 228
|
250 260
....*....|....*....|....*....
gi 489016068 230 E------GFlplpksVTPSRIASNLDCFD 252
Cdd:cd19096 229 EvttvlsGM------STPEQLDENIAAAD 251
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-229 |
6.89e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 80.60 E-value: 6.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQDG--EEAYQATLAALKAGYRHIDTAAIYKN-EESVGRAIKDsgiPREELFITTKLWNdiHTYEEA 85
Cdd:cd19100 8 GLKVSRLGFGGGPLGRLsqEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKG---RRDKVFLATKTGA--RDYEGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 86 QEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKrnaevwRAMEALYNL---GKIRAIGVSNflpHHLEALLETAR- 161
Cdd:cd19100 83 KRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVFGPG------GALEALLEAkeeGKIRFIGISG---HSPEVLLRALEt 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489016068 162 -----MTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGELFQNPAVqavadkygkTIAQvALAWSLQ 229
Cdd:cd19100 154 gefdvVLFPINPAGDHIDSFREELLPLAREKGVGVIAMKVLAGGRLLSGDPL---------DPEQ-ALRYALS 216
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
15-266 |
4.09e-17 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 79.92 E-value: 4.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 15 LGFGTWKAQDGEEAYQATLA-ALKAGYRHIDTAAIY----------KNEESVGRAIKDSGiPREELFITTKL-------- 75
Cdd:cd19094 6 LGTMTWGEQNTEAEAHEQLDyAFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKKG-NRDKVVLATKVagpgegit 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 WND----IHTYEEAQEAFAASMERLGLDYLDLYLIHWPN-PKPLRENN---AWKKRNAEV-----WRAMEALYNLGKIRA 142
Cdd:cd19094 85 WPRgggtRLDRENIREAVEGSLKRLGTDYIDLYQLHWPDrYTPLFGGGyytEPSEEEDSVsfeeqLEALGELVKAGKIRH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 143 IGVSNFLPHHLEALLETARmtpavnQIRLAPGVYQTEAVNF------------CREHEILLEAWGPFGQGEL-------- 202
Cdd:cd19094 165 IGLSNETPWGVMKFLELAE------QLGLPRIVSIQNPYSLlnrnfeeglaeaCHRENVGLLAYSPLAGGVLtgkyldga 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 203 -----------------FQNPAVQA-------VADKYGKTIAQVALAWSLQEGFlplpksVTPSRI-AS-------NLDC 250
Cdd:cd19094 239 arpeggrlnlfpgymarYRSPQALEavaeyvkLARKHGLSPAQLALAWVRSRPF------VTSTIIgATtleqlkeNIDA 312
|
330
....*....|....*.
gi 489016068 251 FDIELDDadlEVLKNV 266
Cdd:cd19094 313 FDVPLSD---ELLAEI 325
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
8-261 |
5.86e-17 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 78.82 E-value: 5.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFG----TWKAQ--DGEEAYQATLAALKAGYRHIDTAAIYKNEES------VGRAIKDSGIPREELFITTKL 75
Cdd:cd19077 1 NGKLVGPIGLGlmglTWRPNptPDEEAFETMKAALDAGSNLWNGGEFYGPPDPhanlklLARFFRKYPEYADKVVLSVKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 WNDIHTYEE--AQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWkkrnAEVWRAMEALYNLGKIRAIGVSnflphhl 153
Cdd:cd19077 81 GLDPDTLRPdgSPEAVRKSIENILRALGGTKKIDIFEPARVDPNVPI----EETIKALKELVKEGKIRGIGLS------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLETARMTPAVNQIR--------LAPGVYQTEAVNFCREHEILLEAWGPFG--------------------------Q 199
Cdd:cd19077 150 EVSAETIRRAHAVHPIAaveveyslFSREIEENGVLETCAELGIPIIAYSPLGrglltgriksladipegdfrrhldrfN 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 200 GELFQN-----PAVQAVADKYGKTIAQVALAWSL---QEGFLPLPKSVTPSRIASNLDCFDIELDDADLE 261
Cdd:cd19077 230 GENFEKnlklvDALQELAEKKGCTPAQLALAWILaqsGPKIIPIPGSTTLERVEENLKAANVELTDEELK 299
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
5-260 |
6.39e-17 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 79.02 E-value: 6.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGT------WKAQDGEEAYQATL-AALKAGYRHIDTAAIY-KNEESVGRAIKDSGIPREELFITTK-- 74
Cdd:cd19144 6 LGRNGPSVPALGFGAmglsafYGPPKPDEERFAVLdAAFELGCTFWDTADIYgDSEELIGRWFKQNPGKREKIFLATKfg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 ---------LWNDiHTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAwkkrnaevwRAMEALYNLGKIRAIGV 145
Cdd:cd19144 86 ieknvetgeYSVD-GSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTV---------AAMAELVQEGKIKHIGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 146 SnflphhlEALLETARMTPAVN-----QIRLAPGVYQTEA-----VNFCREHEILLEAWGPFGQGEL---FQNP------ 206
Cdd:cd19144 156 S-------ECSAETLRRAHAVHpiaavQIEYSPFSLDIERpeigvLDTCRELGVAIVAYSPLGRGFLtgaIRSPddfeeg 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 207 ----------------------AVQAVADKYGKTIAQVALAWSLQEG--FLPLPKSVTPSRIASNLDCFDIELDDADL 260
Cdd:cd19144 229 dfrrmaprfqaenfpknlelvdKIKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEENLGALKVKLTEEEE 306
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
12-228 |
1.43e-16 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 76.75 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTW-------KAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDsgiPREELFITTKLWNDIHT 81
Cdd:cd19086 3 VSEIGFGTWglggdwwGDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKG---RRDKVVIATKFGNRFDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQ---------EAFAASMERLGLDYLDLYLIHWPNPKPLrennawkkRNAEVWRAMEALYNLGKIRAIGVSnflPHH 152
Cdd:cd19086 80 GPERPqdfspeyirEAVEASLKRLGTDYIDLYQLHNPPDEVL--------DNDELFEALEKLKQEGKIRAYGVS---VGD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 153 LEALLETARMTPAV------NQIRLAPGvyqTEAVNFCREHEILLEAWGPFGQGELfqnpavqavadkYGKtIAQVALAW 226
Cdd:cd19086 149 PEEALAALRRGGIDvvqviyNLLDQRPE---EELFPLAEEHGVGVIARVPLASGLL------------TGK-LAQAALRF 212
|
..
gi 489016068 227 SL 228
Cdd:cd19086 213 IL 214
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
13-250 |
2.59e-16 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 76.50 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGTWKAQDG------EEAYQATLAALKAGYRHIDTAAIYKN-EESVGRAIkdSGIPREELFITTKLW--------N 77
Cdd:cd19095 1 SVLGLGTSGIGRVwgvpseAEAARLLNTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGthgeggrdR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 78 DIHTYEEAQEAFAASMERLGLDYLDLYLIHWPNPkplrennawKKRNAEVWRAMEALYNLGKIRAIGVSNFLPhHLEALL 157
Cdd:cd19095 79 KDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSD---------DELTGEVLETLEDLKAAGKVRYIGVSGDGE-ELEAAI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 158 ETAR----MTPaVNQIRLApgvyQTEAVNFCREHEILLEAWGPFGQGELFQNPAVQAVADKY-----------GKTIAQV 222
Cdd:cd19095 149 ASGVfdvvQLP-YNVLDRE----EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYarrpefaaeigGATWAQA 223
|
250 260 270
....*....|....*....|....*....|
gi 489016068 223 ALAWSLQEGFLP--LPKSVTPSRIASNLDC 250
Cdd:cd19095 224 ALRFVLSHPGVSsaIVGTTNPEHLEENLAA 253
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-230 |
6.05e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 75.31 E-value: 6.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTwkAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKdsGIPREELFITTK--LWNDIHT 81
Cdd:cd19105 8 KTGLKVSRLGFGG--GGLPRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALK--GLRRDKVFLATKasPRLDKKD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 82 YEEAQEAFAASMERLGLDYLDLYLIHwpnpkpLRENNAWKKRNAEVWRAMEALYNLGKIRAIGVS--NFLPHHLEALLET 159
Cdd:cd19105 84 KAELLKSVEESLKRLQTDYIDIYQLH------GVDTPEERLLNEELLEALEKLKKEGKVRFIGFSthDNMAEVLQAAIES 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489016068 160 AR---MTPAVNqIRLAPGvYQTEAVNFCREHEILLEAWGPFGQGelFQNPAVQAVADKYGKTIAQVALAWSLQE 230
Cdd:cd19105 158 GWfdvIMVAYN-FLNQPA-ELEEALAAAAEKGIGVVAMKTLAGG--YLQPALLSVLKAKGFSLPQAALKWVLSN 227
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
13-258 |
1.41e-15 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 74.90 E-value: 1.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGT------WKAQDGEEAYQATLAALKAGYRHIDTAAIYKN-EESVGRAIKdsGIPREELFITTKL-----WNDIH 80
Cdd:cd19090 1 SALGLGTaglggvFGGVDDDEAVATIRAALDLGINYIDTAPAYGDsEERLGLALA--ELPREPLVLSTKVgrlpeDTADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAwkkrNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLET- 159
Cdd:cd19090 79 SADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILA----PGGALEALLELKEEGLIKHIGLGGGPPDLLRRAIETg 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 160 --------ARMTPaVNQIRLapgvyqTEAVNFCREHEILLEAWGPFGQGELFQNP--------------------AVQAV 211
Cdd:cd19090 155 dfdvvltaNRYTL-LDQSAA------DELLPAAARHGVGVINASPLGMGLLAGRPpervrytyrwlspelldrakRLYEL 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489016068 212 ADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFDIELDDA 258
Cdd:cd19090 228 CDEHGVPLPALALRFLLRD---PRISTVlvgasSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
14-226 |
4.36e-15 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 73.74 E-value: 4.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 14 VLGFGTWKAQDG---EEAYQATLAALKA-GYRHIDTAAIY---KNEESVGRAikdsGIPREELFITTK---LWNDIHTYE 83
Cdd:cd19075 4 ILGTMTFGSQGRfttAEAAAELLDAFLErGHTEIDTARVYpdgTSEELLGEL----GLGERGFKIDTKanpGVGGGLSPE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 84 EAQEAFAASMERLGLDYLDLYLIHWPNPK-PLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETAR- 161
Cdd:cd19075 80 NVRKQLETSLKRLKVDKVDVFYLHAPDRStPL----------EETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKe 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 162 ---MTPAVNQirlapGVY-------QTEAVNFCREHEILLEAWGPFGQG-----------------------------EL 202
Cdd:cd19075 150 ngwVLPTVYQ-----GMYnaitrqvETELFPCLRKLGIRFYAYSPLAGGfltgkykysedkagggrfdpnnalgklyrDR 224
|
250 260 270
....*....|....*....|....*....|.
gi 489016068 203 FQNPA-------VQAVADKYGKTIAQVALAW 226
Cdd:cd19075 225 YWKPSyfealekVEEAAEKEGISLAEAALRW 255
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
9-265 |
8.58e-15 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 72.65 E-value: 8.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDsgiPREELFITTKLWNDIH----- 80
Cdd:cd19078 8 GLGCMGMSHGYGPPPDKEEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKP---FRDQVVIATKFGFKIDggkpg 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 ------TYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSnflphhlE 154
Cdd:cd19078 85 plgldsRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIE---------EVAGTMKELIKEGKIRHWGLS-------E 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 ALLETARMTPAV-------NQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGEL---------------------FQNP 206
Cdd:cd19078 149 AGVETIRRAHAVcpvtavqSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLtgkidentkfdegddraslprFTPE 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489016068 207 AVQA----------VADKYGKTIAQVALAWSLQEG--FLPLPKSVTPSRIASNLDCFDIELDDADLEVLKN 265
Cdd:cd19078 229 ALEAnqalvdllkeFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPEELREIED 299
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-266 |
2.25e-14 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 71.47 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFGTW-------KAQDGEEAYQATLAALKAGYRHIDTAAIYKN-EESVGRAIK---DSGIPREELFITTKLWNDIH 80
Cdd:cd19101 2 ISRVINGMWqlsgghgGIRDEDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGEFRKrlrRERDAADDVQIHTKWVPDPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 ----TYEEAQEAFAASMERLGLDYLDLYLIHWpnpkplrennaW---KKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHL 153
Cdd:cd19101 82 eltmTRAYVEAAIDRSLKRLGVDRLDLVQFHW-----------WdysDPGYLDAAKHLAELQEEGKIRHLGLTNFDTERL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLEtARMTPAVNQIRLA-----PgvyQTEAVNFCREHEI--------------------------------------L 190
Cdd:cd19101 151 REILD-AGVPIVSNQVQYSlldrrP---ENGMAALCEDHGIkllaygtlaggllsekylgvpeptgpaletrslqkyklM 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 191 LEAWGPFGqgeLFQN--PAVQAVADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19101 227 IDEWGGWD---LFQEllRTLKAIADKHGVSIANVAVRWVLDQ---PGVAGVivgarNSEHIDDNVRAFSFRLDDEDRAAI 300
|
...
gi 489016068 264 KNV 266
Cdd:cd19101 301 DAV 303
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
24-263 |
1.20e-13 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 69.52 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 24 DGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSgipREELFITTKLWNDIHTYEEAQ--------EAFAAS 92
Cdd:cd19087 28 DEETSFAIMDRALDAGINFFDTADVYgggRSEEIIGRWIAGR---RDDIVLATKVFGPMGDDPNDRglsrrhirRAVEAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 93 MERLGLDYLDLYLIHWPNPK-PLREnnawkkrnaeVWRAMEALYNLGKIRAIGVSNFLPHHLEALLETAR----MTPAVN 167
Cdd:cd19087 105 LRRLQTDYIDLYQMHHFDRDtPLEE----------TLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAArrglLRFVSE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 168 Q------IRLApgvyQTEAVNFCREHEILLEAWGPFGQG------------------------ELFQNPAV-------QA 210
Cdd:cd19087 175 QpmynllKRQA----ELEILPAARAYGLGVIPYSPLAGGlltgkygkgkrpesgrlveraryqARYGLEEYrdiaerfEA 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 211 VADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19087 251 LAAEAGLTPASLALAWVLSH---PAVTSPiigprTLEQLEDSLAALEITLTPELLAEI 305
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-266 |
6.27e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 64.66 E-value: 6.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGTWKAQDGEEAYQ---------ATLA-----ALKAGYRHIDTAAIY---KNEESVGRAIKDsgIPREELFITTKL 75
Cdd:cd19103 5 PKIALGTWSWGSGGAGGDqvfgnhldeDTLKavfdkAMAAGLNLWDTAAVYgmgASEKILGEFLKR--YPREDYIISTKF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 WNDI-HTYEEA-QEAFAASMERLGLDYLDLYLIHWPNPKPlrennAWKKRNAevwrameALYNLGKIRAIGVSNflpHHL 153
Cdd:cd19103 83 TPQIaGQSADPvADMLEGSLARLGTDYIDIYWIHNPADVE-----RWTPELI-------PLLKSGKVKHVGVSN---HNL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EallETARmtpaVNQIrLAPGVYQTEAV-----------------NFCREHEILLEAWGPFGQGELF-----QNP----- 206
Cdd:cd19103 148 A---EIKR----ANEI-LAKAGVSLSAVqnhysllyrsseeagilDYCKENGITFFAYMVLEQGALSgkydtKHPlpegs 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489016068 207 ------------------AVQAVADKYGKTIAQVALAWSLQEGFLPLPKSVTPSRIASNLDCFDIELDDADLEVLKNV 266
Cdd:cd19103 220 graetynpllpqleeltaVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-228 |
7.86e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 64.26 E-value: 7.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 15 LGFGTWK----AQDGEEAYQATLAALKAGYRHIDTAAIYKNEES---VGRAIK----DSGIPREELFITTK--------- 74
Cdd:cd19099 6 LGLGTYRgdsdDETDEEYREALKAALDSGINVIDTAINYRGGRSerlIGKALRelieKGGIKRDEVVIVTKagyipgdgd 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 -------------------------LWNDIH-TYEEAQeaFAASMERLGLDYLDLYLIHwpNP---KPLRENNAWKKRNA 125
Cdd:cd19099 86 eplrplkyleeklgrglidvadsagLRHCISpAYLEDQ--IERSLKRLGLDTIDLYLLH--NPeeqLLELGEEEFYDRLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 126 EVWRAMEALYNLGKIRAIGVS-NFLPHHLEALLETARMTPAVNQIRLAPG-------------VYQTEAVN--------- 182
Cdd:cd19099 162 EAFEALEEAVAEGKIRYYGIStWDGFRAPPALPGHLSLEKLVAAAEEVGGdnhhfkviqlplnLLEPEALTekntvkgea 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489016068 183 -----FCREHEILLEAWGPFGQGELFQ-NPAVQAVADKYGKTIAQVALAWSL 228
Cdd:cd19099 242 lslleAAKELGLGVIASRPLNQGQLLGeLRLADLLALPGGATLAQRALQFAR 293
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
13-258 |
6.43e-11 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 61.47 E-value: 6.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGT------WKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDsgIPREELFITTKL-------- 75
Cdd:cd19152 1 PKLGFGTaplgnlYEAVSDEEAKATLVAAWDLGIRYFDTAPWYgagLSEERLGAALRE--LGREDYVISTKVgrllvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 ----------WNDIH-------TYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRENNAWKKRNA--EVWRAMEALYN 136
Cdd:cd19152 79 eveptfepgfWNPLPfdavfdySYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESDEHFAQAikGAFRALEELRE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 137 LGKIRAIGVSNFLPHHLEALLETArmtpAVNQIRLApGVY----QTEAVNF---CREHEILLEAWGPFGQGELFQNP--- 206
Cdd:cd19152 159 EGVIKAIGLGVNDWEVILRILEEA----DLDWVMLA-GRYtlldHSAARELlpeCEKRGVKVVNAGPFNSGFLAGGDnfd 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489016068 207 ----------------AVQAVADKYGKTIAQVALAWSLQegfLPLPKSV-----TPSRIASNLDCFDIELDDA 258
Cdd:cd19152 234 yyeygpappeliarrdRIEALCEQHGVSLAAAALQFALA---PPAVASVapgasSPERVEENVALLATEIPAA 303
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
8-229 |
7.05e-11 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 61.71 E-value: 7.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTWKA---QDGEEAYQATL-AALKAGYRHIDTAAIYKN---EESVGRAIKDSGIPREELFITTKL-WNdi 79
Cdd:cd19142 9 SGLRVSNVGLGTWSTfstAISEEQAEEIVtLAYENGINYFDTSDAFTSgqaETELGRILKKKGWKRSSYIVSTKIyWS-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQ-------EAFAASMERLGLDYLDLYLIHWPNPK-PLRennawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPH 151
Cdd:cd19142 87 YGSEERGlsrkhiiESVRASLRRLQLDYIDIVIIHKADPMcPME----------EVVRAMSYLIDNGLIMYWGTSRWSPV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 152 HLEALLETARmtpAVNQIrlAPGVYQTEAVNFCREH-EI-LLE----------AWGPFGQG-------ELFQNPA----- 207
Cdd:cd19142 157 EIMEAFSIAR---QFNCP--TPICEQSEYHMFCREKmELyMPElynkvgvgliTWSPLSLGldpgiseETRRLVTklsfk 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 489016068 208 --------------------------VQAVADKYGKTIAQVALAWSLQ 229
Cdd:cd19142 232 sskykvgsdgngiheetrrashklreLSLIAERLGCDLTQLLIAWSLK 279
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
13-249 |
3.82e-10 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 59.29 E-value: 3.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGTWK----AQDGEEAYQATL-AALKAGYRHIDTAAIY---KNEESVGRAIKdsGIPREELFITTKLWNDIHTYEE 84
Cdd:cd19162 1 PRLGLGAASlgnlARAGEDEAAATLdAAWDAGIRYFDTAPLYglgLSERRLGAALA--RHPRAEYVVSTKVGRLLEPGAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 85 AQEA-------FAA---------SMERLGLDYLDLYLIHWPNPKPLREnnawkkrNAEVWRAMEALYNLGKIRAIGVSNf 148
Cdd:cd19162 79 GRPAgadrrfdFSAdgirrsieaSLERLGLDRLDLVFLHDPDRHLLQA-------LTDAFPALEELRAEGVVGAIGVGV- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 149 lpHHLEALLETARMTPaVNQIRLApGVY-------QTEAVNFCREHEILLEAWGPFGQGELFQNP--------------- 206
Cdd:cd19162 151 --TDWAALLRAARRAD-VDVVMVA-GRYtlldrraATELLPLCAAKGVAVVAAGVFNSGILATDDpagdrydyrpatpev 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489016068 207 -----AVQAVADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLD 249
Cdd:cd19162 227 lararRLAAVCRRYGVPLPAAALQFPLRH---PAVASVvvgaaSPAELRDNLA 276
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
17-263 |
5.97e-10 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 58.77 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 17 FGT-WKAQDGEEAYQATLAA-LKAGYRHIDTAAIYKNEES---VGRAIKDSgipREELFITTKL-WNDIHTYEEAQ---- 86
Cdd:cd19080 20 FGTeWGWGADREEARAMFDAyVEAGGNFIDTANNYTNGTSerlLGEFIAGN---RDRIVLATKYtMNRRPGDPNAGgnhr 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 87 ----EAFAASMERLGLDYLDLYLIHWPN---PKPlrennawkkrnaEVWRAMEALYNLGKIRAIGVSNFlPHHLEA---L 156
Cdd:cd19080 97 knlrRSVEASLRRLQTDYIDLLYVHAWDfttPVE------------EVMRALDDLVRAGKVLYVGISDT-PAWVVAranT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 157 LETAR-MTPAVN-QIR--LAPGVYQTEAVNFCREHEILLEAWGPFGQGEL---------------FQNP----------- 206
Cdd:cd19080 164 LAELRgWSPFVAlQIEysLLERTPERELLPMARALGLGVTPWSPLGGGLLtgkyqrgeegrageaKGVTvgfgklternw 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489016068 207 ----AVQAVADKYGKTIAQVALAWSLQ--EGFLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19080 244 aivdVVAAVAEELGRSAAQVALAWVRQkpGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARL 306
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
14-252 |
2.24e-09 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 56.79 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 14 VLG---FGTwkAQDGEEAYQATLAALKAGYRHIDTAAIY-------KNEESVGRAIKDSGIpREELFITTK----LWNDI 79
Cdd:cd19082 4 VLGtadFGT--RIDEEEAFALLDAFVELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-RDKVVIATKgghpDLEDM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 H----TYEEAQEAFAASMERLGLDYLDLYLIHWPNP-KPLrennawkkrnAEVWRAMEALYNLGKIRAIGVSNFLPHHLE 154
Cdd:cd19082 81 SrsrlSPEDIRADLEESLERLGTDYIDLYFLHRDDPsVPV----------GEIVDTLNELVRAGKIRAFGASNWSTERIA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 ALLETAR----MTPAVNQIR--LA-------PG---VYQT-EAVNFCREHEILLEAWGPFGQG----------------- 200
Cdd:cd19082 151 EANAYAKahglPGFAASSPQwsLArpneppwPGptlVAMDeEMRAWHEENQLPVFAYSSQARGffskraaggaeddselr 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489016068 201 ELFQNPA-------VQAVADKYGKTIAQVALAWSLQEGFL--PLPKSVTPSRIASNLDCFD 252
Cdd:cd19082 231 RVYYSEEnferlerAKELAEEKGVSPTQIALAYVLNQPFPtvPIIGPRTPEQLRDSLAAAD 291
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
12-266 |
8.90e-08 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 52.55 E-value: 8.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 12 IPVLGFG--TWKAQDGEEAYQATL-AALKAGYRHIDTAAIYK----------NEESVGRAIKDSGiPREELFITTKLWND 78
Cdd:PRK10625 13 VSTLGLGtmTFGEQNSEADAHAQLdYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKRG-SREKLIIASKVSGP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 79 IHTYEEA------------QEAFAASMERLGLDYLDLYLIHWPNpkplRENNAWKKRN------AEVWRAMEALYNL--- 137
Cdd:PRK10625 92 SRNNDKGirpnqaldrkniREALHDSLKRLQTDYLDLYQVHWPQ----RPTNCFGKLGyswtdsAPAVSLLETLDALaeq 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 138 ---GKIRAIGVSNFLPH------HLEALLETARMTPAVNQIRLAPGVYQTEAVNFCREHEILLEAWGPFGQGEL------ 202
Cdd:PRK10625 168 qraGKIRYIGVSNETAFgvmrylHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGTLtgkyln 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 203 -----------------FQNPAVQ-------AVADKYGKTIAQVALAWSLQEGFLP--LPKSVTPSRIASNLDCFDIELD 256
Cdd:PRK10625 248 gakpagarntlfsrftrYSGEQTQkavaayvDIAKRHGLDPAQMALAFVRRQPFVAstLLGATTMEQLKTNIESLHLTLS 327
|
330
....*....|
gi 489016068 257 DADLEVLKNV 266
Cdd:PRK10625 328 EEVLAEIEAV 337
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
7-261 |
9.47e-08 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 52.17 E-value: 9.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGT------WKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKdsGIPREELFITTK--- 74
Cdd:cd19163 8 KTGLKVSKLGFGAsplggvFGPVDEEEAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKALK--GIPRDSYYLATKvgr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 ---LWNDI--HTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPLRE---NnawkkrnaEVWRAMEALYNLGKIRAIGVS 146
Cdd:cd19163 86 yglDPDKMfdFSAERITKSVEESLKRLGLDYIDIIQVHDIEFAPSLDqilN--------ETLPALQKLKEEGKVRFIGIT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 147 NF-----------LPHHLEALLETARMTpaVNQIRLapgvyqTEAVNFCREHEILLEAWGPFGQGELFQNP--------- 206
Cdd:cd19163 158 GYpldvlkevlerSPVKIDTVLSYCHYT--LNDTSL------LELLPFFKEKGVGVINASPLSMGLLTERGppdwhpasp 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489016068 207 -----AVQAVA--DKYGKTIAQVALAWSLQEGFLP--LPKSVTPSRIASNLDCFDIELDDADLE 261
Cdd:cd19163 230 eikeaCAKAAAycKSRGVDISKLALQFALSNPDIAttLVGTASPENLRKNLEAAEEPLDAHLLA 293
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
34-159 |
4.50e-07 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 49.83 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 34 AALKAGYRHIDTAAIYKNEESV-GRAIKDSgiprEELFITTKL----WNDIHTYEEAQEAFAASMERLGLDYLDLYLIHW 108
Cdd:cd19097 34 YALKAGINTLDTAPAYGDSEKVlGKFLKRL----DKFKIITKLpplkEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHN 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 489016068 109 PnpkplrenNAWKKRNAEVWRAMEALYNLGKIRAIGVSNFLPHHLEALLET 159
Cdd:cd19097 110 P--------DDLLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALES 152
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
4-228 |
7.76e-07 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 49.52 E-value: 7.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 4 YLLNNGVGIPVLGFGTW----KAQDGEEAYQATLAALKAGYRHIDTAAIYKN---EESVGRAIKDSGIPREELFITTKL- 75
Cdd:cd19143 5 RLGRSGLKVSALSFGSWvtfgNQVDVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIKELGWPRSDYVVSTKIf 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 W-------NDI-----HTYEeaqeAFAASMERLGLDYLDLYLIHWPNPK-PLRennawkkrnaEVWRAMEALYNLGKIRA 142
Cdd:cd19143 85 WggggpppNDRglsrkHIVE----GTKASLKRLQLDYVDLVFCHRPDPAtPIE----------ETVRAMNDLIDQGKAFY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 143 IGVSNFLPHHLEALLETAR----MTPAVNQIR---LAPGVYQTEAVNFCREHEILLEAWGPFGQGEL------------- 202
Cdd:cd19143 151 WGTSEWSAQQIEEAHEIADrlglIPPVMEQPQynlFHRERVEVEYAPLYEKYGLGTTTWSPLASGLLtgkynngipegsr 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489016068 203 FQNP---------------------AVQAVADKYGKTIAQVALAWSL 228
Cdd:cd19143 231 LALPgyewlkdrkeelgqekiekvrKLKPIAEELGCSLAQLAIAWCL 277
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
35-263 |
1.19e-06 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 48.97 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 35 ALKAGYRHIDTAAIY---KNEESVGRAIKDSgiPREELFITTKLwnDIHTYEEA-----------QEAFAASMERLGLDY 100
Cdd:cd19145 42 AFNSGVTFLDTSDIYgpnTNEVLLGKALKDG--PREKVQLATKF--GIHEIGGSgvevrgdpayvRAACEASLKRLDVDY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 101 LDLYLIHWPNPK-PLRENnawkkrnaevWRAMEALYNLGKIRAIGVSnflphhlEALLETARMTPAVNQI-------RLA 172
Cdd:cd19145 118 IDLYYQHRIDTTvPIEIT----------MGELKKLVEEGKIKYIGLS-------EASADTIRRAHAVHPItavqlewSLW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 173 PGVYQTEAVNFCREHEILLEAWGPFGQG------ELFQNPA-------------------------VQAVADKYGKTIAQ 221
Cdd:cd19145 181 TRDIEEEIIPTCRELGIGIVPYSPLGRGffagkaKLEELLEnsdvrkshprfqgenleknkvlyerVEALAKKKGCTPAQ 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489016068 222 VALAWSLQEG--FLPLPKSVTPSRIASNLDCFDIELDDADLEVL 263
Cdd:cd19145 261 LALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-249 |
1.80e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 48.10 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLG---FGTwkAQDGEEAYQATLAALKAGYRHIDTAAIY----------KNEESVGRAIKDSGIpREELFITTKL---W 76
Cdd:cd19752 3 LCLGtmyFGT--RTDEETSFAILDRYVAAGGNFLDTANNYafwteggvggESERLIGRWLKDRGN-RDDVVIATKVgagP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 NDIHTYEEAQEAFAA---------SMERLGLDYLDLYLIHWPNPK-PLREnnawkkrnaevwrAMEALYNL---GKIRAI 143
Cdd:cd19752 80 RDPDGGPESPEGLSAetieqeidkSLRRLGTDYIDLYYAHVDDRDtPLEE-------------TLEAFNELvkaGKVRAI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 144 GVSNFLPHHLEALLETARMT-----PAVNQ----IRLAPGVY-------QTEAVNFCREH-EILLEAWGPFGQG------ 200
Cdd:cd19752 147 GASNFAAWRLERARQIARQQgwaefSAIQQrhsyLRPRPGADfgvqrivTDELLDYASSRpDLTLLAYSPLLSGaytrpd 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489016068 201 ----ELFQNP-------AVQAVADKYGKTIAQVALAWSLQE--GFLPLPKSVTPSRIASNLD 249
Cdd:cd19752 227 rplpEQYDGPdsdarlaVLEEVAGELGATPNQVVLAWLLHRtpAIIPLLGASTVEQLEENLA 288
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
7-230 |
3.49e-06 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 47.64 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTWK---AQDGEEAYQATL-AALKAGYRHIDTAAIY-----KNEESVGRAIKDSGIP-REELFITTKLw 76
Cdd:cd19089 6 RSGLHLPAISLGLWHnfgDYTSPEEARELLrTAFDLGITHFDLANNYgpppgSAEENFGRILKRDLRPyRDELVISTKA- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 ndihTYEEAQEAFA-------------ASMERLGLDYLDLYLIHWPNPK-PLREnnawkkrnaevwrAMEALYNL---GK 139
Cdd:cd19089 85 ----GYGMWPGPYGdggsrkyllasldQSLKRMGLDYVDIFYHHRYDPDtPLEE-------------TMTALADAvrsGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 140 IRAIGVSNFLPHHLE---ALLETARMTPAVNQIRlapgvYQTeavnFCR--EHEIL--LEAWG-------PFGQGEL--- 202
Cdd:cd19089 148 ALYVGISNYPGAKARraiALLRELGVPLIIHQPR-----YSL----LDRwaEDGLLevLEEAGigfiafsPLAQGLLtdk 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 489016068 203 ---------------------FQNPAVQ-------AVADKYGKTIAQVALAWSLQE 230
Cdd:cd19089 219 ylngippdsrraaeskflteeALTPEKLeqlrklnKIAAKRGQSLAQLALSWVLRD 274
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
8-95 |
5.11e-06 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 46.76 E-value: 5.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTwKAQDGEEAYQA--TLA-ALKAGYRHIDTAAIYKNEES---VGRAIKDSGIPREELFITTKLWN-DIH 80
Cdd:cd19153 13 SPVGLGTAALGG-VYGDGLEQDEAvaIVAeAFAAGINHFDTSPYYGAESSeavLGKALAALQVPRSSYTVATKVGRyRDS 91
|
90
....*....|....*
gi 489016068 81 TYEEAQEAFAASMER 95
Cdd:cd19153 92 EFDYSAERVRASVAT 106
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-146 |
7.40e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 46.49 E-value: 7.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFG------TWKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSgipREELFITTK----- 74
Cdd:cd19104 9 GLKVSELTFGgggiggLMGRTTREEQIAAVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL---PAGPYITTKvrldp 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 -LWNDIhtYEEAQEAFAASMERLGLDYLDLYLIHwpN------PKPLREN---NAWKKRNaEVWRAMEALYNLGKIRAIG 144
Cdd:cd19104 86 dDLGDI--GGQIERSVEKSLKRLKRDSVDLLQLH--NrigderDKPVGGTlstTDVLGLG-GVADAFERLRSEGKIRFIG 160
|
..
gi 489016068 145 VS 146
Cdd:cd19104 161 IT 162
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
8-274 |
8.77e-06 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 46.19 E-value: 8.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTWKAQDG----EEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTKL-WNDI 79
Cdd:cd19159 9 SGLRVSCLGLGTWVTFGGqisdEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKKGWRRSSLVITTKLyWGGK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQ------EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHL 153
Cdd:cd19159 89 AETERGLsrkhiiEGLKGSLQRLQLEYVDVVFANRPDSNTPME---------EIVRAMTHVINQGMAMYWGTSRWSAMEI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLETARmtpavnQIRLAPGV-YQTEAVNFCRE----------HEILLEA--WGPFGQGEL---FQNPAVQA------- 210
Cdd:cd19159 160 MEAYSVAR------QFNMIPPVcEQAEYHLFQREkvevqlpelyHKIGVGAmtWSPLACGIIsgkYGNGVPESsraslkc 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 211 -------------------------VADKYGKTIAQVALAWSLQ-EGFLP-LPKSVTPSRIASNLDCFDIeLDDADLEVL 263
Cdd:cd19159 234 yqwlkerivseegrkqqnklkdlspIAERLGCTLPQLAVAWCLRnEGVSSvLLGSSTPEQLIENLGAIQV-LPKMTSHVV 312
|
330
....*....|.
gi 489016068 264 KNVSGLAGGAP 274
Cdd:cd19159 313 NEIDNILRNKP 323
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
5-229 |
2.85e-05 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 44.69 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 5 LLNNGVGIPVLGFGTWKAQDG----EEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTKL-W 76
Cdd:cd19158 6 LGKSGLRVSCLGLGTWVTFGGqitdEMAEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKKGWRRSSLVITTKIfW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 77 NDIHTYEEAQ------EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLP 150
Cdd:cd19158 86 GGKAETERGLsrkhiiEGLKASLERLQLEYVDVVFANRPDPNTPME---------ETVRAMTHVINQGMAMYWGTSRWSS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 151 HHLEALLETARmtpavnQIRLAPGV-YQTEAVNFCRE----------HEILLEA--WGPF-------------------- 197
Cdd:cd19158 157 MEIMEAYSVAR------QFNLIPPIcEQAEYHMFQREkvevqlpelfHKIGVGAmtWSPLacgivsgkydsgippysras 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489016068 198 ---------------GQGELFQNPAVQAVADKYGKTIAQVALAWSLQ 229
Cdd:cd19158 231 lkgyqwlkdkilseeGRRQQAKLKELQAIAERLGCTLPQLAIAWCLR 277
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
9-229 |
1.05e-04 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 42.82 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 9 GVGIPVLGFGTWKAQDG----EEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTKL-WNDIH 80
Cdd:cd19141 9 GLRVSCLGLGTWVTFGSqisdEVAEELVTLAYENGINLFDTAEVYaagKAEIVLGKILKKKGWRRSSYVITTKIfWGGKA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 81 TYEEAQ------EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHLE 154
Cdd:cd19141 89 ETERGLsrkhiiEGLKASLERLQLEYVDIVFANRPDPNTPME---------EIVRAFTHVINQGMAMYWGTSRWSAMEIM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 155 ALLETARmtpavnQIRLAPGVY-QTEAVNFCRE----------HEILLEA--WGPF------------------------ 197
Cdd:cd19141 160 EAYSVAR------QFNLIPPIVeQAEYHLFQREkvemqlpelfHKIGVGAmtWSPLacgilsgkyddgvpeysraslkgy 233
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489016068 198 ---------GQGELFQNP--AVQAVADKYGKTIAQVALAWSLQ 229
Cdd:cd19141 234 qwlkekilsEEGRRQQAKlkELQIIADRLGCTLPQLAIAWCLK 276
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
130-270 |
3.61e-04 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 41.11 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 130 AMEALYNL---GKIRAIGVSNFLPHHLEallETARMTPAV---NQIRLAPgvyqteavnfcREHEILLEAWG-------- 195
Cdd:PRK10376 146 PLTVLAELqrqGLVRHIGLSNVTPTQVA---EARKIAEIVcvqNHYNLAH-----------RADDALIDALArdgiayvp 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 196 --PFGQGELFQNPAVQAVADKYGKTIAQVALAWSLQEG----FLPLPKSVTPSRiaSNLDCFDIELDDADLEVLKNVSGL 269
Cdd:PRK10376 212 ffPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLQRSpnilLIPGTSSVAHLR--ENLAAAELVLSEEVLAELDGIARE 289
|
.
gi 489016068 270 A 270
Cdd:PRK10376 290 A 290
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
8-231 |
1.50e-03 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 39.58 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 8 NGVGIPVLGFGTW---KAQDGEEAYQATLA-ALKAGYRHIDTAAIY---KNEESVGRAIKDSGIPREELFITTKL-WNDI 79
Cdd:cd19160 11 SGLRVSCLGLGTWvtfGSQISDETAEDLLTvAYEHGVNLFDTAEVYaagKAERTLGNILKSKGWRRSSYVVTTKIyWGGQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 80 HTYEEAQ------EAFAASMERLGLDYLDLYLIHWPNPKPLREnnawkkrnaEVWRAMEALYNLGKIRAIGVSNFLPHHL 153
Cdd:cd19160 91 AETERGLsrkhiiEGLRGSLDRLQLEYVDIVFANRSDPNSPME---------EIVRAMTYVINQGMAMYWGTSRWSAMEI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 154 EALLETARmtpavnQIRLAPGV-YQTEAVNFCRE----------HEILLEA--WGPF----------------------- 197
Cdd:cd19160 162 MEAYSVAR------QFNLIPPVcEQAEYHLFQREkvemqlpelyHKIGVGSvtWSPLacglitgkydgrvpdtcraavkg 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489016068 198 ------------GQGELFQNPAVQAVADKYGKTIAQVALAWSLQ-EG 231
Cdd:cd19160 236 yqwlkekvqseeGKKQQAKVKELHPIADRLGCTVAQLAIAWCLRsEG 282
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
34-264 |
1.74e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 39.25 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 34 AALKAGYRHIDTAAIY-KNEESVGRAIKDSGIPREELFITTKlWNDIHTYE--------EAQEAFAASMERLGLDYLDL- 103
Cdd:cd19098 43 AAWAAGVRYFDAARSYgRAEEFLGSWLRSRNIAPDAVFVGSK-WGYTYTADwqvdaavhEVKDHSLARLLKQWEETRSLl 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 104 ------YLIHWPNPkplrENNAWKkrNAEVWRAMEALYNLGkiRAIGVSNFLPHHLEALLETarMTPAVNQIRLAPGVYQ 177
Cdd:cd19098 122 gkhldlYQIHSATL----ESGVLE--DADVLAALAELKAEG--VKIGLSLSGPQQAETLRRA--LEIEIDGARLFDSVQA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 178 TEAVNFCREHEILLEA----WG-----PFGQGEL-FQNPAVQ---------AVADKYGKTIAQVALAWSLQEGFLP--LP 236
Cdd:cd19098 192 TWNLLEQSAGEALEEAheagMGvivkeALANGRLtDRNPSPElaplmavlkAVADRLGVTPDALALAAVLAQPFVDvvLS 271
|
250 260
....*....|....*....|....*...
gi 489016068 237 KSVTPSRIASNLDCFDIELDDADLEVLK 264
Cdd:cd19098 272 GAATPEQLRSNLRALDVSLDLELLAALA 299
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
34-162 |
6.20e-03 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 37.64 E-value: 6.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 34 AALKAGYRHIDTAAIYKNEESV-GRAIKD--SGIPREELFITTK---LWNDIHTYEEA--QEAFAASMERLGLDYLDLYL 105
Cdd:cd19164 42 RALELGIRAFDTSPYYGPSEIIlGRALKAlrDEFPRDTYFIITKvgrYGPDDFDYSPEwiRASVERSLRRLHTDYLDLVY 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 106 IHwpnpkplrenNAWKKRNAEVWRAMEALYNL---GKIRAIGVSNFlPhhLEALLETARM 162
Cdd:cd19164 122 LH----------DVEFVADEEVLEALKELFKLkdeGKIRNVGISGY-P--LPVLLRLAEL 168
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
7-231 |
7.83e-03 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 37.38 E-value: 7.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 7 NNGVGIPVLGFGTWKAQDGEEAYQATLA----ALKAGYRHIDTAAIY-----KNEESVGRAIKDSGIP-REELFITTK-- 74
Cdd:cd19151 7 RSGLKLPAISLGLWHNFGDVDRYENSRAmlrrAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKPyRDELIISTKag 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 75 --LWNDIHTYEEAQEAFAASME----RLGLDYLDLYLIHWPNPK-PLRENnawkkrnaevWRAMEALYNLGKIRAIGVSN 147
Cdd:cd19151 87 ytMWPGPYGDWGSKKYLIASLDqslkRMGLDYVDIFYHHRPDPEtPLEET----------MGALDQIVRQGKALYVGISN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 148 FLPhhlealLETARMTPAVNQIRLAPGVYQTEAVNFCREHE----ILLEAWG-------PFGQGEL-------------- 202
Cdd:cd19151 157 YPP------EEAREAAAILKDLGTPCLIHQPKYSMFNRWVEegllDVLEEEGigciafsPLAQGLLtdrylngipedsra 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 489016068 203 -----FQNP------------AVQAVADKYGKTIAQVALAWSLQEG 231
Cdd:cd19151 231 akgssFLKPeqiteeklakvrRLNEIAQARGQKLAQMALAWVLRNK 276
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
13-253 |
9.99e-03 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 36.92 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 13 PVLGFGT------WKAQDGEEAYQATLAALKAGYRHIDTAAIY---KNEESVGRAIKDsgIPREELFITTKL-------- 75
Cdd:cd19161 1 SELGLGTaglgnlYTAVSNADADATLDAAWDSGIRYFDTAPMYghgLAEHRLGDFLRE--KPRDEFVLSTKVgrllkpar 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 76 ---------WNDI--------HTYEEAQEAFAASMERLGLDYLDLYLIHWPNPKPL---RENNAWKKRNAEVWRAMEALY 135
Cdd:cd19161 79 egsvpdpngFVDPlpfeivydYSYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHgdrKERHHFAQLMSGGFKALEELK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489016068 136 NLGKIRAI--GVSNFlphhlEALLETARMTPaVNQIRLApGVY----QTEAVNF---CREHEILLEAWGPFGQGELFQNP 206
Cdd:cd19161 159 KAGVIKAFglGVNEV-----QICLEALDEAD-LDCFLLA-GRYslldQSAEEEFlprCEQRGTSLVIGGVFNSGILATGT 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489016068 207 --------------------AVQAVADKYGKTIAQVALAWSLQEgflPLPKSV-----TPSRIASNLDCFDI 253
Cdd:cd19161 232 ksgakfnygdapaeiisrvmEIEKICDAYNVPLAAAALQFPLRH---PAVASVltgarNPAQLRQNVEAFQT 300
|
|
| |
