|
Name |
Accession |
Description |
Interval |
E-value |
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
2-462 |
0e+00 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 804.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 2 LAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVG 81
Cdd:PRK09556 1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 82 KTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFL 161
Cdd:PRK09556 81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 162 GFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 242 ENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 322 ANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 402 FAKLGLGMIAD----GTPVFG--LTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQT 462
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTI 467
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
28-444 |
1.56e-170 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 485.21 E-value: 1.56e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 28 FMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAI 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 108 CMLGFSASMGAGStSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLF 187
Cdd:cd17345 81 INILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 188 DGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFS 267
Cdd:cd17345 160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 268 NIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH 346
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDkLFKGRRAPTGIIFMILVIVALIVYWL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 347 ASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADgtpvfgLTGWAGTF 426
Cdd:cd17345 320 APNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVD------HFGWNGGF 393
|
410
....*....|....*...
gi 489012754 427 AALDAAAVGCICLMAIVA 444
Cdd:cd17345 394 IVLLASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-426 |
2.54e-143 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 414.85 E-value: 2.54e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 36 FIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSAS 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 116 mgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIgmF 195
Cdd:TIGR00881 81 -----TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--F 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 196 IFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAiSEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVR 275
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 276 IGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH--ASNQYV 352
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLM 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADG------FGWAGAF 379
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
20-458 |
3.18e-61 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 206.10 E-value: 3.18e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 20 RRKMWfkpfmQSYLVVFIGYLTMYLIRKNFNIAQNDMISTyGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLP 99
Cdd:PRK11273 24 RRLRW-----QIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 100 FMLILSAICMLgFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVA 179
Cdd:PRK11273 98 AGLILAAAVML-FMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 180 LFGANYLFDGHviGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEElFGEAISEEDKETEENAMTKWQIFVEYVLKNK 259
Cdd:PRK11273 177 LLGMAWFNDWH--AALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEE-YKNDYPDDYNEKHEQELTAKQIFMQYVLPNK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 260 VIWLLCFSNIFLYVVRIGIDQWSTVYafqeLKLSKEVAIQ----GFTLFEVGALVGTLLWGWLSD-LANGRRALVACIAL 334
Cdd:PRK11273 254 LLWYIAIANVFVYLLRYGILDWSPTY----LKEVKHFALDksswAYFLYEYAGIPGTLLCGWMSDkVFRGNRGATGVFFM 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 335 ALI-IATLgVY--QHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIA 411
Cdd:PRK11273 330 TLVtIATI-VYwlNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTV 408
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 489012754 412 DgtpvfgLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNR 458
Cdd:PRK11273 409 D------FFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
17-433 |
7.94e-60 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 201.86 E-value: 7.94e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 17 LDVRRKMWFKPFMqsyLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQ 96
Cdd:PRK11663 13 IDARYRYWRRHIL---ITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 97 FLPFMLILSAICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAA 176
Cdd:PRK11663 90 FMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 177 GVALFGAnyLFDGHVIGMfIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAIsEEDKETEENAMTKWQIFVEYVL 256
Cdd:PRK11663 165 LVVGAIA--LHYGWRYGM-MIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDAL-ELAQQQEGAGLSRKEILTKYVL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 257 KNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACI-AL 334
Cdd:PRK11663 241 LNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGPMNLIfAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 335 ALIIATLGVYQHASNQYVYLAS-LFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADg 413
Cdd:PRK11663 321 GILLSVGSLWLMPFASYVMQAAcFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLE- 398
|
410 420
....*....|....*....|
gi 489012754 414 tpvfgLTGWAGTFAALDAAA 433
Cdd:PRK11663 399 -----IWHWTGFFVVISIAA 413
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-440 |
5.51e-51 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 176.70 E-value: 5.51e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 30 QSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICM 109
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 110 LGFSAsmgagSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYlFDG 189
Cdd:cd17312 83 IFMGF-----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY-YGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 190 HVIgmFIFPSIIALIVGFIGLRYGSDSPesyglgtaeelfgeaiseedketeenamtkwqifveyvlknKVIWLLCFSNI 269
Cdd:cd17312 157 RAA--FLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 270 FLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLA-NGRRALVACIALALIIATLGVYQHAS 348
Cdd:cd17312 194 FVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFFP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 349 NQYVYLASLFAL-GFLVFGPQLLIG-VAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:cd17312 274 HNKLLSIVLLFLiGFFVGGPINLIGgAAAQDIGRKEAAGTATGFVGLFGY-LGASLAGLPLGYIIDH------YGWSTVF 346
|
410
....*....|....
gi 489012754 427 AALDAAAVGCICLM 440
Cdd:cd17312 347 YFLISAALLSVLLL 360
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
35-441 |
4.78e-49 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 171.43 E-value: 4.78e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFsa 114
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILF-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 115 smgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNlggagaagvalfganylfdghvIGM 194
Cdd:cd17488 86 ---GFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHN----------------------IGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPESYGLGTAeelfgeaiseedketeenamtkwqIFVEYVLKNK--VIWLLCFSNIFLY 272
Cdd:cd17488 141 ALIPILTGFAALTYGWRAGMYVPGIIAILMG------------------------IVLCWRLRDRppYIWLLAFCYVLVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACI-ALALIIATLGVYQHASNQ 350
Cdd:cd17488 197 VVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDkLFKGNRGPMNLIfALGLLVSVGALWLVPVHS 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 351 YVYLASLF-ALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADgtpvfgLTGWAGTFAAL 429
Cdd:cd17488 277 YWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYL-GAALAGYPLAKVIE------SWGWSGFFIVI 349
|
410
....*....|..
gi 489012754 430 DAAAVGCICLMA 441
Cdd:cd17488 350 SIAAAISGLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-444 |
3.34e-40 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 147.71 E-value: 3.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 sasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2271 93 -----GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGlrygsdspesyglgtaeelfgeaiseedketeenamtkwqifveyvlknkvIWLLCFSNIFLY 272
Cdd:COG2271 165 AAFLILGLPGLLLALLR---------------------------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfgLTGWAGTFAALDAA 432
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLD------ATGYQAAFLLLAAL 346
|
410
....*....|..
gi 489012754 433 AVGCICLMAIVA 444
Cdd:COG2271 347 ALLAALLALLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-451 |
1.39e-22 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 99.33 E-value: 1.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 31 SYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICML 110
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 111 GFSasmgaGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdGH 190
Cdd:cd17343 84 AFS-----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY--GW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 191 VIGMFIfPSIIALIVGFIGLRYGSDSPESYGLgtaeelfgEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIF 270
Cdd:cd17343 157 RSTLSI-SGTVAVVMSVVCLLFIKNEPSDVGL--------NNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 271 LYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLA----NGRRALVACIALAL---IIATLGV 343
Cdd:cd17343 228 VFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhGSSSRGNPRMPLALvfmAGLTVSL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 344 Y------QHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvf 417
Cdd:cd17343 308 HlfrvhiTSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAK----- 381
|
410 420 430
....*....|....*....|....*....|....
gi 489012754 418 gLTGWAGTFAALDaaavgCICLMAIVAIFEERKI 451
Cdd:cd17343 382 -HYDWRTAFLLLE-----ILCAITVVILFLLRNI 409
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-429 |
1.03e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 93.26 E-value: 1.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFsa 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 115 smgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGAnYLFDGHVIGM 194
Cdd:cd06174 79 ---AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPEsyglgtaeelfgeaisEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVV 274
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPE----------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 275 RIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVAcIALALIIATLGVYQHASNQYVYL 354
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 355 ASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADGTPVFGLTGWAGTFAAL 429
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
33-455 |
1.94e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 1.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 SASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2223 88 ALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAIseedketeenamtkwqifveyVLKNKVIWLLCFSNIFLY 272
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE---------------------ALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALaLIIATLGVYQHASNQYV 352
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL-MALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLvFGPQLLIGVAAVG-FVPKKAIGAADGIKGTfAYLIGDSFAKLGLGMIADgtpvfgltgWAGTFAALDA 431
Cdd:COG2223 298 FLVLFLLLGLA-LGGGNGAVFALVPdIFPTKNAGAVYGLVGA-AGGLGGFLGPLLFGALLD---------ATGSYTAAFL 366
|
410 420
....*....|....*....|....
gi 489012754 432 AAVGCICLMAIVAIFEERKIRREK 455
Cdd:COG2223 367 VFAVLALVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-400 |
3.54e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 82.71 E-value: 3.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 33 LVVFIGYLTMYLIrknfNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2814 17 LGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 sasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2814 93 -----ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGsdspesyglgtaeelfgeaiseedKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLY 272
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLL------------------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVacIALALIIATLGVYQHASNQYV 352
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD 400
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-399 |
1.74e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.54 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 35 VFIGYLTMYLIRKNFNIA-QNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLgfs 113
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 114 asMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVIG 193
Cdd:pfam07690 78 --LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 194 MFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISeedketeenamtkwqifVEYVLKNKVIWLLCFSnIFLYV 273
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----------------WKALLRDPVLWLLLAL-LLFGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 274 VRIGIDQWSTVYAfQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:pfam07690 215 AFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIG 399
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
67-448 |
2.75e-14 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 74.28 E-value: 2.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYS 146
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 147 TITKWTPRRKRGTFLGFWNiSHNlggagaagVALFGANYLFDGHVI----GM-FIFPSIIALIVGFIGLRYGSDSPEsyg 221
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWN-SHT--------SVGNILGSLIAGIFVssawGLsFIVPGIIIAAMGVLVFLFLVEHPP--- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 222 lGTAEelfgeaiseedketeenamtkwqiFVEYVLKNKVIwllcfSNIFLYvvrigidqWSTVYAFQELKLSKEVAIQGF 301
Cdd:cd17344 212 -GVIE------------------------FSLCLFFAKLV-----SYTFLY--------WLPLYISNTAILSAKKAGDLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 302 TLFEVGALVGTLLWGWLSDLANGrRALVACIALALIIATLGVYQH--ASNQYVYLASLFALGFLVFGPQLLIGVAAvgfv 379
Cdd:cd17344 254 TLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYNYfgQVSMTTNIVLLIVCGLLVNGPYALITTAV---- 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 380 pkkaigAADgiKGTFAYLIGDSFAKLGLGMIADGTPVFGL------------TGWAGTFAALDAAAVgCICLMAIVAIFE 447
Cdd:cd17344 329 ------SAD--LGTHKSLKGNARALATVTAIIDGTGSIGAalgpllaglissRGWNNVFYMLIAADV-CAGLLLTRLVYK 399
|
.
gi 489012754 448 E 448
Cdd:cd17344 400 E 400
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-446 |
3.16e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 70.66 E-value: 3.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 56 MISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMlgfsaSMGAGSTSLFLMIAFYALSGF 135
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGL-----SLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 136 fqstgGSCSY----STITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDghvIGMFIFPSIIALIVGFIGLR 211
Cdd:cd17478 97 -----GSAAFhpegARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG---LGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 212 YGSDSPESYGLGTAEELFGEAiseedketeenamtkwqifveYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYaFQELK 291
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARST---------------------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 292 LSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIiaTLGVYQHASNQYVYLaSLFALGFLVFGPQLLI 371
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAP--FLLLFLLTPGIWSYI-LLVLAGFLLFASFPVT 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 372 GVAAVGFVPKKaIGAADGIKGTFAYLIGdsfaklGLGMIadgtpvfgLTGWAGTFAALDAAAVGCICLMAIVAIF 446
Cdd:cd17478 304 VVLAQELLPGN-VGLASGLMMGLSFGLG------GIGAP--------VLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-442 |
1.12e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 69.14 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAIcmlgF 112
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL----F 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 SASMGAGsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANyLFDGHvi 192
Cdd:cd17319 82 TALTGFA-TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWR-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGsdspesyglgtaeelfgeaiseedketeenamtkwqifveyvlknKVIWLLCFSNIFLY 272
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYL---------------------------------------------RQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELklskevaiqGFTLFEVG---------ALVGTLLWGWLSD-LANGRRALVACIALALIIATLG 342
Cdd:cd17319 193 YALYGLLTWLPTYLKQAR---------GFSLKQVGllaaipflaGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 343 VYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTpvfGLTGW 422
Cdd:cd17319 264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVDAT---GSYTA 339
|
410 420
....*....|....*....|
gi 489012754 423 AGTFAALdAAAVGCICLMAI 442
Cdd:cd17319 340 AFLFLAA-VALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-454 |
1.25e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 23 MWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFML 102
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 103 ILSAICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKR---GTFLGFWNISHNLGGAGAAGVA 179
Cdd:COG0738 81 LLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 180 LFGANYLFDGHVIGMFIFPSIIALIVGFIGLRygsdspesyglgtaeelfgeAISEEDKETEENAMTKWQIFveyvlKNK 259
Cdd:COG0738 156 LLGLSLSWHLPYLILAVLLLLLALLFLRSKLP--------------------EIEEEEEEAAGSAASLKSLL-----KNP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 260 VIWLLCFSnIFLYV-VRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALII 338
Cdd:COG0738 211 RLLLGGLA-IFLYVgAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 339 ATLGVYqhASNQYVYLASLFALGFLVfGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfg 418
Cdd:COG0738 290 LLLALL--APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLAD------ 359
|
410 420 430
....*....|....*....|....*....|....*.
gi 489012754 419 LTGWAGTFAALdaaaVGCICLMAIVAIFEERKIRRE 454
Cdd:COG0738 360 AFGLRAAFLVP----LVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-442 |
3.82e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.36 E-value: 3.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 32 YLVVFIGYLTMYLIRKNFNIaqndMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLG 111
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 112 FsasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHV 191
Cdd:cd17325 78 F-----AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGL------------------GFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IG---------------MFIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiseedKETEENAMTKWQIFVEYVL 256
Cdd:cd17325 135 IGpllgglladalgyraPFLVCAALALLALVLALLLLPEPRPP------------------PNKRAVSAARLRSGLRLLL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 257 KNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRalVACIALAL 336
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP--LILIGLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 337 IIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFaYLIGDSFAKLGLGMIADgtpv 416
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYD---- 349
|
410 420
....*....|....*....|....*.
gi 489012754 417 fgLTGWAGTFAALDAAAVGCICLMAI 442
Cdd:cd17325 350 --AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-441 |
1.34e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.48 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 56 MISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGfsasmGAGSTSLFLMIAFYALSGF 135
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL-----MALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 136 FQSTGGSCSYSTITKWTPRRKRGTFLGFwnishnlggagaagvalfganylfdgHVIGMFIFPSIIALIVGFIGLRYGSD 215
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGI--------------------------RQTGVPLGGALAAALLPPLALHYGWR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 216 SpeSYGLGTAEELFGEAIS-------EEDKETEENAMTKWQIFVEyVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQ 288
Cdd:cd17475 151 A--AFVVAGLVSILAAVLFwlfyrepPAASAATESASTLLRSLKE-VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 289 ELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQ--HASNQYVYLASLFAL-GFLV 364
Cdd:cd17475 228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRRPVLVITAAIAAAALLVLSllSPGTPLWLLVLLLILlGLFA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 365 FGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLigdsfaklglgMIADGTPVFGL-----TGWAGTFAALDAAAVGCICL 439
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFI-----------GIAIGPPLFGLlvdatHSYAPAWLALALLLVLAALL 376
|
..
gi 489012754 440 MA 441
Cdd:cd17475 377 LL 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-439 |
2.36e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.09 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 34 VVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpfmlILSAICMLGFS 113
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK-------WILAVGILIWS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 114 ASMGAGS--TSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17328 76 AATLLSSfaPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IgmFIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiSEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFL 271
Cdd:cd17328 156 A--FRVTGVLGVLLAILLLLFVREPPRG--------------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 272 YVVRIGIDQWSTVY---AFQELKLSKEVAIQGFTLFE-VGALVGTLLWGWLSDLANGR----RALVACIAL--ALIIATL 341
Cdd:cd17328 220 SFVTGALAFWAPTFflrAFGVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRKtpraDPLVCAVGLlaAAPFLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 342 GVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIAD------GTP 415
Cdd:cd17328 300 ALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllrqnkDSP 379
|
410 420
....*....|....*....|....*
gi 489012754 416 VFGLTGWA-GTFAALDAAAVGCICL 439
Cdd:cd17328 380 LAEAASLQyALLLCSFVLVLGGFFF 404
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-435 |
4.62e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.92 E-value: 4.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 60 YGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpFMLILSAICMLGFSASMGAGSTSLFLMIaFYALSGFFQST 139
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRK----KALILTLLLFGLATLLIGLLPTPILLLV-LRFLQGIGIGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 140 GGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVI-GMFIFPSIIALIVGFIGLRygsdspe 218
Cdd:cd17316 106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWrILFLIGALPALLALLLRRR------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 219 syglgtaeelfgeaiseedketeenamtkwqifveyvlknkvIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAI 298
Cdd:cd17316 179 ------------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 299 QGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGF 378
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 379 VPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVG 435
Cdd:cd17316 297 FPTEVRATGVGLSYNLGRLGG-GGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-374 |
9.29e-07 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 50.78 E-value: 9.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSA-SMGAGSTSLFLMIAFYALSGFFQSTGGSCSY 145
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVlTEWLHFYNKYLYCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 146 STITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHVIGmfifpSIIALIVGFIGLRYGSdspesygLGTA 225
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASV------------------GNIIG-----ALLASSVLDYGYEYAF-------LVTS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 226 EELFGEAISeedketeenamtkwqIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFE 305
Cdd:cd17342 195 SLLFAGAIV---------------VFFGLLSSPPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 306 VGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVYQHASNQYVYLASLFAL-GFLVFGPQLLIGVA 374
Cdd:cd17342 260 VGGIIGGIVAGYISDRM-GSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTItGFFIGGPANLISSA 328
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
193-449 |
1.61e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 49.99 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIglRYGSDSPESYglgtaeelfgeAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFsnIFLY 272
Cdd:cd17371 158 VLFLLGALPALLVLFI--RRFVKEPPQW-----------QAARAARRHFADRPSLRELFSPPLLRTTLLASLLA--TGAL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGSAISILLYFFLPLSPTL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGikgtFAYLIGDSFAKLG---LGMIADGtpvfglTGWAGTFAAL 429
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQG----FCYNVGRIIGALFpflVGFLATS------GSLGTAIAVF 371
|
250 260
....*....|....*....|
gi 489012754 430 daAAVGCICLMAIVAIFEER 449
Cdd:cd17371 372 --AAVYYIAGLVLALLLPET 389
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-362 |
4.37e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 4.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 58 STYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTK--QFLPFMLILSAICMLG----FSASMGAGSTSLFLMIAFYA 131
Cdd:COG2211 39 DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSfvllFTAPDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 132 LSGFFQSTGGSCSYSTITKWTP-RRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFpSIIALIVGFIGL 210
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLT-ALIFAVLGLLAF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 211 rygsdspesyglgtaeeLFGEAISEEDKETEENAMTKWQIFVEyVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQEL 290
Cdd:COG2211 198 -----------------LLTFFGTKERPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489012754 291 KLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGF 362
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-372 |
2.62e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.47 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 33 LVVFIGYLTMYLIRKNFNIAQ-NDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLG 111
Cdd:cd17327 8 PLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 112 fsasmGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17327 88 -----TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IG---MFIFPSIIALIVGFIGLRYGSDSPE-SYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEyVLKNKVIWLLCFS 267
Cdd:cd17327 163 AGwrwLFIIEGLITIIIGLVIFFWLPDNPSkAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKE-AFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 268 NIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGAlVGTLLWGWLSDLANGRRALV---ACIALALIIATLGVY 344
Cdd:cd17327 242 FFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGA-VSLLIAALLSDRFKKRGLFAifaCVLALVGSIILLAAP 320
|
330 340
....*....|....*....|....*...
gi 489012754 345 QHASNqyvYLASLFALGFLVFGPQLLIG 372
Cdd:cd17327 321 NPPGA---YFAAYILGGGSYAGFPILLS 345
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-170 |
5.04e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 19 VRRKMWFKPFMQSYLVVFIGYLTMYLIrknFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFL 98
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL 276
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489012754 99 PFMLILSAICMLGFsasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:COG2814 277 LIGLLLLALGLLLL-----ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-170 |
6.51e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.79 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 26 KPFMQSYLVVFIGYLTMYLIRKNFNIaqnDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILS 105
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 106 AICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:cd17325 276 AVALLLLPLA-----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
283-443 |
1.14e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 283 TVYAfQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACiALALIIATLGVYQHASNQYVYLASLFALGF 362
Cdd:cd17477 212 PLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC-ALLGALAALLLPLVPGLPLALLVLLFLWGG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 363 LVFGPQLLIGVAAVGFVPKKAIGAADGIkGTFAYligdsfaklGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAI 442
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAA-LLLLY---------GLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
.
gi 489012754 443 V 443
Cdd:cd17477 360 L 360
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
281-368 |
1.67e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 281 WSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVY---QHASNQYVYLASL 357
Cdd:cd17369 250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV-GRRPVYLAGALLAALFAFPFFwllDTGSTWLIVLAAV 328
|
90
....*....|....
gi 489012754 358 FALGFL---VFGPQ 368
Cdd:cd17369 329 VVLGVLhgmMYGPQ 342
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
261-445 |
2.04e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.26 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 261 IWLLCFSNIFLYVvriGIDQWsTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALI-IA 339
Cdd:cd17365 176 LWVTFFMGLLLVY---LLNSW-LPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVsLA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 340 TLGVYQHASNqyVYLASLFALGFLVFGPQLLIGVAAVGFVPKK----AIGAADGIkGTFAYLIGdsfAKLGLGMIADGTP 415
Cdd:cd17365 252 LLGVSPASLV--LLYVLVFLAGACVNGAQVGLYALAARFYPTEvratGVGWALGV-GRLGAILG---PLLGGLLLAAGLG 325
|
170 180 190
....*....|....*....|....*....|
gi 489012754 416 VFGLtgwagtFAALdaAAVGCICLMAIVAI 445
Cdd:cd17365 326 PESV------FLAL--AIPAALGALAVLLL 347
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
282-367 |
2.63e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 282 STVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFAlg 361
Cdd:COG2270 261 AGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIG-- 338
|
....*.
gi 489012754 362 fLVFGP 367
Cdd:COG2270 339 -LVMGG 343
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
195-441 |
5.28e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiseedKETEENAMTKWqifvEYVLKNKVIWLLCFSNIFLYVV 274
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLPTG------------------KASALEFLKVQ----LAVLKNYRTWILSLLYGVTFGS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 275 RIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRAL-----VACIALALIIATLGVyqHASN 349
Cdd:cd17341 221 FVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLwwlfiVMTIGAALLSLSLPT--SGTN 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 350 QYVYLASLFALGFLV-FGPQLLIGVAAvgFVPKKAIGAADGIKGTFAYLIGDSFAKL-GLGMIADGTPVFGLTGWAgtfa 427
Cdd:cd17341 299 LVLFLALFVALGLGAgAGNGSVFRMVP--FIFRRELGAVTGLVGAIGGLGGFFLPLLfGSSALMTGSGVGAFSLFG---- 372
|
250
....*....|....
gi 489012754 428 aldAAAVGCICLMA 441
Cdd:cd17341 373 ---VLAVACTLLVW 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-170 |
7.20e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 9 RKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYY 88
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 89 ADGKNTKQFLPFMLILSAICMLGFSasMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISH 168
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLL--LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
|
..
gi 489012754 169 NL 170
Cdd:pfam07690 337 SL 338
|
|
|