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Conserved domains on  [gi|489012754|ref|WP_002923280|]
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MULTISPECIES: hexose-6-phosphate:phosphate antiporter [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 11484345)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
2-462 0e+00

hexose-6-phosphate:phosphate antiporter;


:

Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 804.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   2 LAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVG 81
Cdd:PRK09556   1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  82 KTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFL 161
Cdd:PRK09556  81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 162 GFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 242 ENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 322 ANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 402 FAKLGLGMIAD----GTPVFG--LTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQT 462
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTI 467
 
Name Accession Description Interval E-value
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
2-462 0e+00

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 804.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   2 LAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVG 81
Cdd:PRK09556   1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  82 KTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFL 161
Cdd:PRK09556  81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 162 GFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 242 ENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 322 ANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 402 FAKLGLGMIAD----GTPVFG--LTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQT 462
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTI 467
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
28-444 1.56e-170

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 485.21  E-value: 1.56e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  28 FMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAI 107
Cdd:cd17345    1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 108 CMLGFSASMGAGStSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLF 187
Cdd:cd17345   81 INILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 188 DGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFS 267
Cdd:cd17345  160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 268 NIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH 346
Cdd:cd17345  240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDkLFKGRRAPTGIIFMILVIVALIVYWL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 347 ASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADgtpvfgLTGWAGTF 426
Cdd:cd17345  320 APNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVD------HFGWNGGF 393
                        410
                 ....*....|....*...
gi 489012754 427 AALDAAAVGCICLMAIVA 444
Cdd:cd17345  394 IVLLASCILAIIFLALVA 411
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
36-426 2.54e-143

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 414.85  E-value: 2.54e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   36 FIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSAS 115
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  116 mgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIgmF 195
Cdd:TIGR00881  81 -----TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--F 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  196 IFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAiSEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVR 275
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  276 IGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH--ASNQYV 352
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLM 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489012754  353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADG------FGWAGAF 379
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-444 3.34e-40

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 147.71  E-value: 3.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 sasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2271   93 -----GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGlrygsdspesyglgtaeelfgeaiseedketeenamtkwqifveyvlknkvIWLLCFSNIFLY 272
Cdd:COG2271  165 AAFLILGLPGLLLALLR---------------------------------------------------FWLLALAYFLVY 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:COG2271  194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfgLTGWAGTFAALDAA 432
Cdd:COG2271  274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLD------ATGYQAAFLLLAAL 346
                        410
                 ....*....|..
gi 489012754 433 AVGCICLMAIVA 444
Cdd:COG2271  347 ALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
35-399 1.74e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   35 VFIGYLTMYLIRKNFNIA-QNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLgfs 113
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  114 asMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVIG 193
Cdd:pfam07690  78 --LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  194 MFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISeedketeenamtkwqifVEYVLKNKVIWLLCFSnIFLYV 273
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----------------WKALLRDPVLWLLLAL-LLFGF 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  274 VRIGIDQWSTVYAfQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:pfam07690 215 AFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 489012754  353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIG 399
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
 
Name Accession Description Interval E-value
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
2-462 0e+00

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 804.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   2 LAFLNQVRKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVG 81
Cdd:PRK09556   1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  82 KTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFL 161
Cdd:PRK09556  81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 162 GFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 242 ENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 322 ANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 402 FAKLGLGMIAD----GTPVFG--LTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNRILQT 462
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKKIQQLTI 467
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
28-444 1.56e-170

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 485.21  E-value: 1.56e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  28 FMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAI 107
Cdd:cd17345    1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 108 CMLGFSASMGAGStSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLF 187
Cdd:cd17345   81 INILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 188 DGHVIGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFS 267
Cdd:cd17345  160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 268 NIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH 346
Cdd:cd17345  240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDkLFKGRRAPTGIIFMILVIVALIVYWL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 347 ASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIADgtpvfgLTGWAGTF 426
Cdd:cd17345  320 APNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVD------HFGWNGGF 393
                        410
                 ....*....|....*...
gi 489012754 427 AALDAAAVGCICLMAIVA 444
Cdd:cd17345  394 IVLLASCILAIIFLALVA 411
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
36-426 2.54e-143

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 414.85  E-value: 2.54e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   36 FIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSAS 115
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  116 mgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIgmF 195
Cdd:TIGR00881  81 -----TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--F 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  196 IFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAiSEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVVR 275
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  276 IGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQH--ASNQYV 352
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLM 312
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489012754  353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADG------FGWAGAF 379
glpT PRK11273
glycerol-3-phosphate transporter;
20-458 3.18e-61

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 206.10  E-value: 3.18e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  20 RRKMWfkpfmQSYLVVFIGYLTMYLIRKNFNIAQNDMISTyGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLP 99
Cdd:PRK11273  24 RRLRW-----QIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLP 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 100 FMLILSAICMLgFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVA 179
Cdd:PRK11273  98 AGLILAAAVML-FMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 180 LFGANYLFDGHviGMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEElFGEAISEEDKETEENAMTKWQIFVEYVLKNK 259
Cdd:PRK11273 177 LLGMAWFNDWH--AALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEE-YKNDYPDDYNEKHEQELTAKQIFMQYVLPNK 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 260 VIWLLCFSNIFLYVVRIGIDQWSTVYafqeLKLSKEVAIQ----GFTLFEVGALVGTLLWGWLSD-LANGRRALVACIAL 334
Cdd:PRK11273 254 LLWYIAIANVFVYLLRYGILDWSPTY----LKEVKHFALDksswAYFLYEYAGIPGTLLCGWMSDkVFRGNRGATGVFFM 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 335 ALI-IATLgVY--QHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIA 411
Cdd:PRK11273 330 TLVtIATI-VYwlNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTV 408
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 489012754 412 DgtpvfgLTGWAGTFAALDAAAVGCICLMAIVAIFEERKIRREKKNR 458
Cdd:PRK11273 409 D------FFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQKR 449
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
17-433 7.94e-60

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 201.86  E-value: 7.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  17 LDVRRKMWFKPFMqsyLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQ 96
Cdd:PRK11663  13 IDARYRYWRRHIL---ITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  97 FLPFMLILSAICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAA 176
Cdd:PRK11663  90 FMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 177 GVALFGAnyLFDGHVIGMfIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAIsEEDKETEENAMTKWQIFVEYVL 256
Cdd:PRK11663 165 LVVGAIA--LHYGWRYGM-MIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDAL-ELAQQQEGAGLSRKEILTKYVL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 257 KNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACI-AL 334
Cdd:PRK11663 241 LNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGPMNLIfAA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 335 ALIIATLGVYQHASNQYVYLAS-LFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADg 413
Cdd:PRK11663 321 GILLSVGSLWLMPFASYVMQAAcFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLE- 398
                        410       420
                 ....*....|....*....|
gi 489012754 414 tpvfgLTGWAGTFAALDAAA 433
Cdd:PRK11663 399 -----IWHWTGFFVVISIAA 413
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
30-440 5.51e-51

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 176.70  E-value: 5.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  30 QSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICM 109
Cdd:cd17312    3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 110 LGFSAsmgagSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYlFDG 189
Cdd:cd17312   83 IFMGF-----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY-YGW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 190 HVIgmFIFPSIIALIVGFIGLRYGSDSPesyglgtaeelfgeaiseedketeenamtkwqifveyvlknKVIWLLCFSNI 269
Cdd:cd17312  157 RAA--FLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYA 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 270 FLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLA-NGRRALVACIALALIIATLGVYQHAS 348
Cdd:cd17312  194 FVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFFP 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 349 NQYVYLASLFAL-GFLVFGPQLLIG-VAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADGtpvfglTGWAGTF 426
Cdd:cd17312  274 HNKLLSIVLLFLiGFFVGGPINLIGgAAAQDIGRKEAAGTATGFVGLFGY-LGASLAGLPLGYIIDH------YGWSTVF 346
                        410
                 ....*....|....
gi 489012754 427 AALDAAAVGCICLM 440
Cdd:cd17312  347 YFLISAALLSVLLL 360
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
35-441 4.78e-49

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 171.43  E-value: 4.78e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFsa 114
Cdd:cd17488    8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILF-- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 115 smgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNlggagaagvalfganylfdghvIGM 194
Cdd:cd17488   86 ---GFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHN----------------------IGG 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPESYGLGTAeelfgeaiseedketeenamtkwqIFVEYVLKNK--VIWLLCFSNIFLY 272
Cdd:cd17488  141 ALIPILTGFAALTYGWRAGMYVPGIIAILMG------------------------IVLCWRLRDRppYIWLLAFCYVLVY 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACI-ALALIIATLGVYQHASNQ 350
Cdd:cd17488  197 VVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDkLFKGNRGPMNLIfALGLLVSVGALWLVPVHS 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 351 YVYLASLF-ALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADgtpvfgLTGWAGTFAAL 429
Cdd:cd17488  277 YWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYL-GAALAGYPLAKVIE------SWGWSGFFIVI 349
                        410
                 ....*....|..
gi 489012754 430 DAAAVGCICLMA 441
Cdd:cd17488  350 SIAAAISGLLLL 361
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-444 3.34e-40

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 147.71  E-value: 3.34e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 sasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2271   93 -----GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGlrygsdspesyglgtaeelfgeaiseedketeenamtkwqifveyvlknkvIWLLCFSNIFLY 272
Cdd:COG2271  165 AAFLILGLPGLLLALLR---------------------------------------------------FWLLALAYFLVY 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:COG2271  194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfgLTGWAGTFAALDAA 432
Cdd:COG2271  274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLD------ATGYQAAFLLLAAL 346
                        410
                 ....*....|..
gi 489012754 433 AVGCICLMAIVA 444
Cdd:COG2271  347 ALLAALLALLLL 358
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
31-451 1.39e-22

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 99.33  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  31 SYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICML 110
Cdd:cd17343    4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 111 GFSasmgaGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdGH 190
Cdd:cd17343   84 AFS-----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY--GW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 191 VIGMFIfPSIIALIVGFIGLRYGSDSPESYGLgtaeelfgEAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIF 270
Cdd:cd17343  157 RSTLSI-SGTVAVVMSVVCLLFIKNEPSDVGL--------NNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLV 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 271 LYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLA----NGRRALVACIALAL---IIATLGV 343
Cdd:cd17343  228 VFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhGSSSRGNPRMPLALvfmAGLTVSL 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 344 Y------QHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvf 417
Cdd:cd17343  308 HlfrvhiTSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAK----- 381
                        410       420       430
                 ....*....|....*....|....*....|....
gi 489012754 418 gLTGWAGTFAALDaaavgCICLMAIVAIFEERKI 451
Cdd:cd17343  382 -HYDWRTAFLLLE-----ILCAITVVILFLLRNI 409
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
35-429 1.03e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 93.26  E-value: 1.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  35 VFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFsa 114
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 115 smgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGAnYLFDGHVIGM 194
Cdd:cd06174   79 ---AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPEsyglgtaeelfgeaisEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLYVV 274
Cdd:cd06174  155 FLIAAALALLAAILLLLVVPDPPE----------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLA 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 275 RIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVAcIALALIIATLGVYQHASNQYVYL 354
Cdd:cd06174  219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLL 297
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 355 ASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLiGDSFAKLGLGMIADGTPVFGLTGWAGTFAAL 429
Cdd:cd06174  298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
33-455 1.94e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 83.78  E-value: 1.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2223    8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 SASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2223   88 ALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---GWR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAIseedketeenamtkwqifveyVLKNKVIWLLCFSNIFLY 272
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE---------------------ALRDPRFWLLSLLYFGTF 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALaLIIATLGVYQHASNQYV 352
Cdd:COG2223  219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAL-MALGLLLLALALGSLWL 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLvFGPQLLIGVAAVG-FVPKKAIGAADGIKGTfAYLIGDSFAKLGLGMIADgtpvfgltgWAGTFAALDA 431
Cdd:COG2223  298 FLVLFLLLGLA-LGGGNGAVFALVPdIFPTKNAGAVYGLVGA-AGGLGGFLGPLLFGALLD---------ATGSYTAAFL 366
                        410       420
                 ....*....|....*....|....
gi 489012754 432 AAVGCICLMAIVAIFEERKIRREK 455
Cdd:COG2223  367 VFAVLALVALVLTLLLYRRPRRAA 390
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-400 3.54e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 82.71  E-value: 3.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIrknfNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGF 112
Cdd:COG2814   17 LGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 sasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVI 192
Cdd:COG2814   93 -----ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---GWR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGsdspesyglgtaeelfgeaiseedKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFLY 272
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLL------------------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVacIALALIIATLGVYQHASNQYV 352
Cdd:COG2814  221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWL 298
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGD 400
Cdd:COG2814  299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
35-399 1.74e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 1.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   35 VFIGYLTMYLIRKNFNIA-QNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLgfs 113
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  114 asMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLfdgHVIG 193
Cdd:pfam07690  78 --LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GWRA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  194 MFIFPSIIALIVGFIGLRYGSDSPESYGLGTAEELFGEAISeedketeenamtkwqifVEYVLKNKVIWLLCFSnIFLYV 273
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----------------WKALLRDPVLWLLLAL-LLFGF 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  274 VRIGIDQWSTVYAfQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:pfam07690 215 AFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 489012754  353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIG 399
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
67-448 2.75e-14

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 74.28  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSASMGAGSTSLFLMIAFYALSGFFQSTGGSCSYS 146
Cdd:cd17344   64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVA 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 147 TITKWTPRRKRGTFLGFWNiSHNlggagaagVALFGANYLFDGHVI----GM-FIFPSIIALIVGFIGLRYGSDSPEsyg 221
Cdd:cd17344  144 CVGNWFGKGKRGLIMGIWN-SHT--------SVGNILGSLIAGIFVssawGLsFIVPGIIIAAMGVLVFLFLVEHPP--- 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 222 lGTAEelfgeaiseedketeenamtkwqiFVEYVLKNKVIwllcfSNIFLYvvrigidqWSTVYAFQELKLSKEVAIQGF 301
Cdd:cd17344  212 -GVIE------------------------FSLCLFFAKLV-----SYTFLY--------WLPLYISNTAILSAKKAGDLS 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 302 TLFEVGALVGTLLWGWLSDLANGrRALVACIALALIIATLGVYQH--ASNQYVYLASLFALGFLVFGPQLLIGVAAvgfv 379
Cdd:cd17344  254 TLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYNYfgQVSMTTNIVLLIVCGLLVNGPYALITTAV---- 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 380 pkkaigAADgiKGTFAYLIGDSFAKLGLGMIADGTPVFGL------------TGWAGTFAALDAAAVgCICLMAIVAIFE 447
Cdd:cd17344  329 ------SAD--LGTHKSLKGNARALATVTAIIDGTGSIGAalgpllaglissRGWNNVFYMLIAADV-CAGLLLTRLVYK 399

                 .
gi 489012754 448 E 448
Cdd:cd17344  400 E 400
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
56-446 3.16e-13

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 70.66  E-value: 3.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  56 MISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMlgfsaSMGAGSTSLFLMIAFYALSGF 135
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGL-----SLLGFAPNYWLLLLLVALAGI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 136 fqstgGSCSY----STITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDghvIGMFIFPSIIALIVGFIGLR 211
Cdd:cd17478   97 -----GSAAFhpegARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG---LGLLILLIIPGLAVALLLLR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 212 YGSDSPESYGLGTAEELFGEAiseedketeenamtkwqifveYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYaFQELK 291
Cdd:cd17478  169 LRPLKKPEAKKAAAKSSARST---------------------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRG 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 292 LSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIiaTLGVYQHASNQYVYLaSLFALGFLVFGPQLLI 371
Cdd:cd17478  227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAP--FLLLFLLTPGIWSYI-LLVLAGFLLFASFPVT 303
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 372 GVAAVGFVPKKaIGAADGIKGTFAYLIGdsfaklGLGMIadgtpvfgLTGWAGTFAALDAAAVGCICLMAIVAIF 446
Cdd:cd17478  304 VVLAQELLPGN-VGLASGLMMGLSFGLG------GIGAP--------VLGALADAFGLESVLLILALLPLLGALL 363
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
33-442 1.12e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.14  E-value: 1.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAIcmlgF 112
Cdd:cd17319    6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL----F 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 113 SASMGAGsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANyLFDGHvi 192
Cdd:cd17319   82 TALTGFA-TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-LFGWR-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIGLRYGsdspesyglgtaeelfgeaiseedketeenamtkwqifveyvlknKVIWLLCFSNIFLY 272
Cdd:cd17319  158 WAFIIEGLLGLLLAVLWWFYL---------------------------------------------RQVWGLALGYFGIN 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELklskevaiqGFTLFEVG---------ALVGTLLWGWLSD-LANGRRALVACIALALIIATLG 342
Cdd:cd17319  193 YALYGLLTWLPTYLKQAR---------GFSLKQVGllaaipflaGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLL 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 343 VYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTpvfGLTGW 422
Cdd:cd17319  264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVDAT---GSYTA 339
                        410       420
                 ....*....|....*....|
gi 489012754 423 AGTFAALdAAAVGCICLMAI 442
Cdd:cd17319  340 AFLFLAA-VALLAALLVLLL 358
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
23-454 1.25e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.95  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  23 MWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFML 102
Cdd:COG0738    1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 103 ILSAICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKR---GTFLGFWNISHNLGGAGAAGVA 179
Cdd:COG0738   81 LLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 180 LFGANYLFDGHVIGMFIFPSIIALIVGFIGLRygsdspesyglgtaeelfgeAISEEDKETEENAMTKWQIFveyvlKNK 259
Cdd:COG0738  156 LLGLSLSWHLPYLILAVLLLLLALLFLRSKLP--------------------EIEEEEEEAAGSAASLKSLL-----KNP 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 260 VIWLLCFSnIFLYV-VRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALII 338
Cdd:COG0738  211 RLLLGGLA-IFLYVgAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 339 ATLGVYqhASNQYVYLASLFALGFLVfGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYlIGDSFAKLGLGMIADgtpvfg 418
Cdd:COG0738  290 LLLALL--APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLAD------ 359
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 489012754 419 LTGWAGTFAALdaaaVGCICLMAIVAIFEERKIRRE 454
Cdd:COG0738  360 AFGLRAAFLVP----LVCYLLILLLALALKRKRRKK 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
32-442 3.82e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.36  E-value: 3.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  32 YLVVFIGYLTMYLIRKNFNIaqndMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLG 111
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 112 FsasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHV 191
Cdd:cd17325   78 F-----AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGL------------------GFL 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IG---------------MFIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiseedKETEENAMTKWQIFVEYVL 256
Cdd:cd17325  135 IGpllgglladalgyraPFLVCAALALLALVLALLLLPEPRPP------------------PNKRAVSAARLRSGLRLLL 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 257 KNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRalVACIALAL 336
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP--LILIGLLL 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 337 IIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFaYLIGDSFAKLGLGMIADgtpv 416
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYD---- 349
                        410       420
                 ....*....|....*....|....*.
gi 489012754 417 fgLTGWAGTFAALDAAAVGCICLMAI 442
Cdd:cd17325  350 --AFGFATPFLAAAALLLLAAVLFLL 373
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
56-441 1.34e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 56.48  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  56 MISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGfsasmGAGSTSLFLMIAFYALSGF 135
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL-----MALVGSYPVLLVLLFLVGA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 136 FQSTGGSCSYSTITKWTPRRKRGTFLGFwnishnlggagaagvalfganylfdgHVIGMFIFPSIIALIVGFIGLRYGSD 215
Cdd:cd17475   97 GYGSVQPGGGRAIMRWFPPRERGLAMGI--------------------------RQTGVPLGGALAAALLPPLALHYGWR 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 216 SpeSYGLGTAEELFGEAIS-------EEDKETEENAMTKWQIFVEyVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQ 288
Cdd:cd17475  151 A--AFVVAGLVSILAAVLFwlfyrepPAASAATESASTLLRSLKE-VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHD 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 289 ELKLSKEVAIQGFTLFEVGALVGTLLWGWLSD-LANGRRALVACIALALIIATLGVYQ--HASNQYVYLASLFAL-GFLV 364
Cdd:cd17475  228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRRPVLVITAAIAAAALLVLSllSPGTPLWLLVLLLILlGLFA 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 365 FGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLigdsfaklglgMIADGTPVFGL-----TGWAGTFAALDAAAVGCICL 439
Cdd:cd17475  308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFI-----------GIAIGPPLFGLlvdatHSYAPAWLALALLLVLAALL 376

                 ..
gi 489012754 440 MA 441
Cdd:cd17475  377 LL 378
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
34-439 2.36e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.09  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  34 VVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpfmlILSAICMLGFS 113
Cdd:cd17328    3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK-------WILAVGILIWS 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 114 ASMGAGS--TSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17328   76 AATLLSSfaPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRW 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IgmFIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiSEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFSNIFL 271
Cdd:cd17328  156 A--FRVTGVLGVLLAILLLLFVREPPRG--------------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAV 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 272 YVVRIGIDQWSTVY---AFQELKLSKEVAIQGFTLFE-VGALVGTLLWGWLSDLANGR----RALVACIAL--ALIIATL 341
Cdd:cd17328  220 SFVTGALAFWAPTFflrAFGVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRKtpraDPLVCAVGLlaAAPFLFL 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 342 GVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGIKGTFAYLIGDSFAKLGLGMIAD------GTP 415
Cdd:cd17328  300 ALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllrqnkDSP 379
                        410       420
                 ....*....|....*....|....*
gi 489012754 416 VFGLTGWA-GTFAALDAAAVGCICL 439
Cdd:cd17328  380 LAEAASLQyALLLCSFVLVLGGFFF 404
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
60-435 4.62e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.92  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  60 YGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKqflpFMLILSAICMLGFSASMGAGSTSLFLMIaFYALSGFFQST 139
Cdd:cd17316   31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRK----KALILTLLLFGLATLLIGLLPTPILLLV-LRFLQGIGIGG 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 140 GGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVI-GMFIFPSIIALIVGFIGLRygsdspe 218
Cdd:cd17316  106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWrILFLIGALPALLALLLRRR------- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 219 syglgtaeelfgeaiseedketeenamtkwqifveyvlknkvIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAI 298
Cdd:cd17316  179 ------------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 299 QGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGFLVFGPQLLIGVAAVGF 378
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489012754 379 VPKKAIGAADGIKGTFAYLIGdSFAKLGLGMIADGTPVFGLTGWAGTFAALDAAAVG 435
Cdd:cd17316  297 FPTEVRATGVGLSYNLGRLGG-GGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
67-374 9.29e-07

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 50.78  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  67 LGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLGFSA-SMGAGSTSLFLMIAFYALSGFFQSTGGSCSY 145
Cdd:cd17342   65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVlTEWLHFYNKYLYCILWVLNGLLQSTGWPCVV 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 146 STITKWTPRRKRGTFLGFWNISHNLggagaagvalfganylfdGHVIGmfifpSIIALIVGFIGLRYGSdspesygLGTA 225
Cdd:cd17342  145 AIMGNWFGKSSRGFVLGLWSACASV------------------GNIIG-----ALLASSVLDYGYEYAF-------LVTS 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 226 EELFGEAISeedketeenamtkwqIFVEYVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFE 305
Cdd:cd17342  195 SLLFAGAIV---------------VFFGLLSSPPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 306 VGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVYQHASNQYVYLASLFAL-GFLVFGPQLLIGVA 374
Cdd:cd17342  260 VGGIIGGIVAGYISDRM-GSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTItGFFIGGPANLISSA 328
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
193-449 1.61e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.99  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 193 GMFIFPSIIALIVGFIglRYGSDSPESYglgtaeelfgeAISEEDKETEENAMTKWQIFVEYVLKNKVIWLLCFsnIFLY 272
Cdd:cd17371  158 VLFLLGALPALLVLFI--RRFVKEPPQW-----------QAARAARRHFADRPSLRELFSPPLLRTTLLASLLA--TGAL 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 273 VVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVYQHASNQYV 352
Cdd:cd17371  223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGSAISILLYFFLPLSPTL 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 353 YLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGAADGikgtFAYLIGDSFAKLG---LGMIADGtpvfglTGWAGTFAAL 429
Cdd:cd17371  302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQG----FCYNVGRIIGALFpflVGFLATS------GSLGTAIAVF 371
                        250       260
                 ....*....|....*....|
gi 489012754 430 daAAVGCICLMAIVAIFEER 449
Cdd:cd17371  372 --AAVYYIAGLVLALLLPET 389
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
58-362 4.37e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  58 STYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTK--QFLPFMLILSAICMLG----FSASMGAGSTSLFLMIAFYA 131
Cdd:COG2211   39 DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSfvllFTAPDLSPTGKLIYALVTYL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 132 LSGFFQSTGGSCSYSTITKWTP-RRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHVIGMFIFpSIIALIVGFIGL 210
Cdd:COG2211  119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLT-ALIFAVLGLLAF 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 211 rygsdspesyglgtaeeLFGEAISEEDKETEENAMTKWQIFVEyVLKNKVIWLLCFSNIFLYVVRIGIDQWSTVYAFQEL 290
Cdd:COG2211  198 -----------------LLTFFGTKERPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489012754 291 KLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFALGF 362
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
33-372 2.62e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.47  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  33 LVVFIGYLTMYLIRKNFNIAQ-NDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILSAICMLG 111
Cdd:cd17327    8 PLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 112 fsasmGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNLGGAGAAGVALFGANYLFDGHV 191
Cdd:cd17327   88 -----TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 192 IG---MFIFPSIIALIVGFIGLRYGSDSPE-SYGLGTAEELFGEAISEEDKETEENAMTKWQIFVEyVLKNKVIWLLCFS 267
Cdd:cd17327  163 AGwrwLFIIEGLITIIIGLVIFFWLPDNPSkAWFLTEEEKELAVERLRANQTGKGDQKFKWKQIKE-AFKDPRTWLLFLF 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 268 NIFLYVVRIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGAlVGTLLWGWLSDLANGRRALV---ACIALALIIATLGVY 344
Cdd:cd17327  242 FFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGA-VSLLIAALLSDRFKKRGLFAifaCVLALVGSIILLAAP 320
                        330       340
                 ....*....|....*....|....*...
gi 489012754 345 QHASNqyvYLASLFALGFLVFGPQLLIG 372
Cdd:cd17327  321 NPPGA---YFAAYILGGGSYAGFPILLS 345
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-170 5.04e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 5.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  19 VRRKMWFKPFMQSYLVVFIGYLTMYLIrknFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFL 98
Cdd:COG2814  200 LRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL 276
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489012754  99 PFMLILSAICMLGFsasmgAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:COG2814  277 LIGLLLLALGLLLL-----ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
26-170 6.51e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.79  E-value: 6.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754  26 KPFMQSYLVVFIGYLTMYLIRKNFNIaqnDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYYADGKNTKQFLPFMLILS 105
Cdd:cd17325  199 RRLLALFLAIFVLAFAFGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489012754 106 AICMLGFSASmgagsTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISHNL 170
Cdd:cd17325  276 AVALLLLPLA-----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
283-443 1.14e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 283 TVYAfQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACiALALIIATLGVYQHASNQYVYLASLFALGF 362
Cdd:cd17477  212 PLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC-ALLGALAALLLPLVPGLPLALLVLLFLWGG 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 363 LVFGPQLLIGVAAVGFVPKKAIGAADGIkGTFAYligdsfaklGLGMIADGTPVFGLTGWAGTFAALDAAAVGCICLMAI 442
Cdd:cd17477  290 AAGPLYTLALALAGDRLPGDELVAANAA-LLLLY---------GLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359

                 .
gi 489012754 443 V 443
Cdd:cd17477  360 L 360
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
281-368 1.67e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 40.59  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 281 WSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLAnGRRALVACIALALIIATLGVY---QHASNQYVYLASL 357
Cdd:cd17369  250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV-GRRPVYLAGALLAALFAFPFFwllDTGSTWLIVLAAV 328
                         90
                 ....*....|....
gi 489012754 358 FALGFL---VFGPQ 368
Cdd:cd17369  329 VVLGVLhgmMYGPQ 342
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
261-445 2.04e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.26  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 261 IWLLCFSNIFLYVvriGIDQWsTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALI-IA 339
Cdd:cd17365  176 LWVTFFMGLLLVY---LLNSW-LPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVsLA 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 340 TLGVYQHASNqyVYLASLFALGFLVFGPQLLIGVAAVGFVPKK----AIGAADGIkGTFAYLIGdsfAKLGLGMIADGTP 415
Cdd:cd17365  252 LLGVSPASLV--LLYVLVFLAGACVNGAQVGLYALAARFYPTEvratGVGWALGV-GRLGAILG---PLLGGLLLAAGLG 325
                        170       180       190
                 ....*....|....*....|....*....|
gi 489012754 416 VFGLtgwagtFAALdaAAVGCICLMAIVAI 445
Cdd:cd17365  326 PESV------FLAL--AIPAALGALAVLLL 347
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
282-367 2.63e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 40.14  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 282 STVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRALVACIALALIIATLGVYQHASNQYVYLASLFAlg 361
Cdd:COG2270  261 AGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIG-- 338

                 ....*.
gi 489012754 362 fLVFGP 367
Cdd:COG2270  339 -LVMGG 343
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
195-441 5.28e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.16  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 195 FIFPSIIALIVGFIGLRYGSDSPESyglgtaeelfgeaiseedKETEENAMTKWqifvEYVLKNKVIWLLCFSNIFLYVV 274
Cdd:cd17341  163 FFVPGILLAIAAVLVLLFGDDLPTG------------------KASALEFLKVQ----LAVLKNYRTWILSLLYGVTFGS 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 275 RIGIDQWSTVYAFQELKLSKEVAIQGFTLFEVGALVGTLLWGWLSDLANGRRAL-----VACIALALIIATLGVyqHASN 349
Cdd:cd17341  221 FVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLwwlfiVMTIGAALLSLSLPT--SGTN 298
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754 350 QYVYLASLFALGFLV-FGPQLLIGVAAvgFVPKKAIGAADGIKGTFAYLIGDSFAKL-GLGMIADGTPVFGLTGWAgtfa 427
Cdd:cd17341  299 LVLFLALFVALGLGAgAGNGSVFRMVP--FIFRRELGAVTGLVGAIGGLGGFFLPLLfGSSALMTGSGVGAFSLFG---- 372
                        250
                 ....*....|....
gi 489012754 428 aldAAAVGCICLMA 441
Cdd:cd17341  373 ---VLAVACTLLVW 383
MFS_1 pfam07690
Major Facilitator Superfamily;
9-170 7.20e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754    9 RKPTLDLPLDVRRKMWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMISTYGLSMTQLGMIGLGFSITYGVGKTLVSYY 88
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012754   89 ADGKNTKQFLPFMLILSAICMLGFSasMGAGSTSLFLMIAFYALSGFFQSTGGSCSYSTITKWTPRRKRGTFLGFWNISH 168
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLL--LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336

                  ..
gi 489012754  169 NL 170
Cdd:pfam07690 337 SL 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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