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Conserved domains on  [gi|489012486|ref|WP_002923018|]
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MULTISPECIES: pyridoxamine 5'-phosphate oxidase family protein [Klebsiella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3576 COG3576
Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily ...
 9-173 2.68e-61

Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily [General function prediction only];


:

Pssm-ID: 442796  Cd Length: 189  Bit Score: 189.27  E-value: 2.68e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486   9 AITPDVmDVQHEMGSDSlwqtPRSRRQ-ADRFGDSEAGMIATRDSFYLATVSQSGWPYIQHRGGPPGFLHLLDDTTLAMA 87
Cdd:COG3576    2 AITPAV-ALQELYGSPA----ARALRKvLDRLTPHERAFIAASPFFFLATVDADGWPDVSPRGGPPGFVRVLDDRTLAFP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486  88 DFGGNRQYITTGNLRGSDRACLFLMDYPRRARLKIYATVEVLaaeDHPQLLAQVAPANYRAriERLFLFHLQAFDWNCPQ 167
Cdd:COG3576   77 DRRGNRRYDSLGNILENPRVGLLFLDPGRRERLRVNGRARIV---TDPALLARLAVEGKRP--ERVIVVTVEEVYFNCPK 151


                 ....*.
gi 489012486 168 HITPRY 173
Cdd:COG3576  152 AITRSG 157
BRLZ smart00338
basic region leucin zipper;
180-205 7.97e-03

basic region leucin zipper;


:

Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 33.69  E-value: 7.97e-03
                           10        20
                   ....*....|....*....|....*.
gi 489012486   180 EYSQNLQQRIHDLEQENQRLQQQLAR 205
Cdd:smart00338  26 AEIEELERKVEQLEAENERLKKEIER 51
 
Name Accession Description Interval E-value
COG3576 COG3576
Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily ...
 9-173 2.68e-61

Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily [General function prediction only];


Pssm-ID: 442796  Cd Length: 189  Bit Score: 189.27  E-value: 2.68e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486   9 AITPDVmDVQHEMGSDSlwqtPRSRRQ-ADRFGDSEAGMIATRDSFYLATVSQSGWPYIQHRGGPPGFLHLLDDTTLAMA 87
Cdd:COG3576    2 AITPAV-ALQELYGSPA----ARALRKvLDRLTPHERAFIAASPFFFLATVDADGWPDVSPRGGPPGFVRVLDDRTLAFP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486  88 DFGGNRQYITTGNLRGSDRACLFLMDYPRRARLKIYATVEVLaaeDHPQLLAQVAPANYRAriERLFLFHLQAFDWNCPQ 167
Cdd:COG3576   77 DRRGNRRYDSLGNILENPRVGLLFLDPGRRERLRVNGRARIV---TDPALLARLAVEGKRP--ERVIVVTVEEVYFNCPK 151


                 ....*.
gi 489012486 168 HITPRY 173
Cdd:COG3576  152 AITRSG 157
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 46-133 4.36e-10

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 54.18  E-value: 4.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486   46 MIATRDSFYLATVSQSGWPYIQHRGGPPGFLHLLDDttlamadFGGNRQYITTGNLRGSDRACLFLMDYPRRARLKIYAT 125
Cdd:pfam01243   8 FLAEPNAVVLATVDKDGRPNVRPVGLKYGFDTVGIL-------FATNTDSRKARNLEENPRVALLFGDPELRRGVRIEGT 80


                  ....*...
gi 489012486  126 VEVLAAED 133
Cdd:pfam01243  81 AEIVTDGE 88
BRLZ smart00338
basic region leucin zipper;
180-205 7.97e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 33.69  E-value: 7.97e-03
                           10        20
                   ....*....|....*....|....*.
gi 489012486   180 EYSQNLQQRIHDLEQENQRLQQQLAR 205
Cdd:smart00338  26 AEIEELERKVEQLEAENERLKKEIER 51
 
Name Accession Description Interval E-value
COG3576 COG3576
Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily ...
 9-173 2.68e-61

Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily [General function prediction only];


Pssm-ID: 442796  Cd Length: 189  Bit Score: 189.27  E-value: 2.68e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486   9 AITPDVmDVQHEMGSDSlwqtPRSRRQ-ADRFGDSEAGMIATRDSFYLATVSQSGWPYIQHRGGPPGFLHLLDDTTLAMA 87
Cdd:COG3576    2 AITPAV-ALQELYGSPA----ARALRKvLDRLTPHERAFIAASPFFFLATVDADGWPDVSPRGGPPGFVRVLDDRTLAFP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486  88 DFGGNRQYITTGNLRGSDRACLFLMDYPRRARLKIYATVEVLaaeDHPQLLAQVAPANYRAriERLFLFHLQAFDWNCPQ 167
Cdd:COG3576   77 DRRGNRRYDSLGNILENPRVGLLFLDPGRRERLRVNGRARIV---TDPALLARLAVEGKRP--ERVIVVTVEEVYFNCPK 151


                 ....*.
gi 489012486 168 HITPRY 173
Cdd:COG3576  152 AITRSG 157
Putative_PNPOx pfam01243
Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family ...
 46-133 4.36e-10

Pyridoxamine 5'-phosphate oxidase; Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both pfam01243 and pfam10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown.


Pssm-ID: 426149 [Multi-domain]  Cd Length: 88  Bit Score: 54.18  E-value: 4.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489012486   46 MIATRDSFYLATVSQSGWPYIQHRGGPPGFLHLLDDttlamadFGGNRQYITTGNLRGSDRACLFLMDYPRRARLKIYAT 125
Cdd:pfam01243   8 FLAEPNAVVLATVDKDGRPNVRPVGLKYGFDTVGIL-------FATNTDSRKARNLEENPRVALLFGDPELRRGVRIEGT 80


                  ....*...
gi 489012486  126 VEVLAAED 133
Cdd:pfam01243  81 AEIVTDGE 88
BRLZ smart00338
basic region leucin zipper;
180-205 7.97e-03

basic region leucin zipper;


Pssm-ID: 197664 [Multi-domain]  Cd Length: 65  Bit Score: 33.69  E-value: 7.97e-03
                           10        20
                   ....*....|....*....|....*.
gi 489012486   180 EYSQNLQQRIHDLEQENQRLQQQLAR 205
Cdd:smart00338  26 AEIEELERKVEQLEAENERLKKEIER 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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