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Conserved domains on  [gi|489007542|ref|WP_002918116|]
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MULTISPECIES: PTS galactitol transporter subunit IIA [Klebsiella]

Protein Classification

PTS galactitol transporter subunit IIA( domain architecture ID 10793303)

PTS galactitol transporter subunit IIA is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

EC:  2.7.1.200
Gene Ontology:  GO:0009401|GO:0015796|GO:0016310|GO:0090584
PubMed:  10393270

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
1-150 2.12e-95

PTS galactitol transporter subunit IIA;


:

Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 272.06  E-value: 2.12e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   1 MSQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIALEKHAVAIPHCEAIHAKSPAIYLIRPDM 80
Cdd:PRK09665   1 MSNLFVRTGISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIHAKSPAIYLIRPDK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542  81 PVSFQRADDDGEIDVSLIIALIVENPAAQLKLLRRLFSELQNPHTLEALLAASDDRLPVRFQQLILEPEL 150
Cdd:PRK09665  81 KVHFQQADDDNDVAVSLVIALIVENPQQQLKLLRCLFGKLQQPDIVETLLTLPETQLKEYFTKYVLDSDE 150
 
Name Accession Description Interval E-value
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
1-150 2.12e-95

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 272.06  E-value: 2.12e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   1 MSQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIALEKHAVAIPHCEAIHAKSPAIYLIRPDM 80
Cdd:PRK09665   1 MSNLFVRTGISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIHAKSPAIYLIRPDK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542  81 PVSFQRADDDGEIDVSLIIALIVENPAAQLKLLRRLFSELQNPHTLEALLAASDDRLPVRFQQLILEPEL 150
Cdd:PRK09665  81 KVHFQQADDDNDVAVSLVIALIVENPQQQLKLLRCLFGKLQQPDIVETLLTLPETQLKEYFTKYVLDSDE 150
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 1-135 3.03e-29

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 103.80  E-value: 3.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   1 MSQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDM 80
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIG---NGIAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489007542  81 PVSFqraDDDGEIDVSLIIALIVENPAAQLKLLRRLFSELQNPHTLEALLAASDD 135
Cdd:cd00211   78 PVDF---GSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSK 129
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 5-134 1.18e-24

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 92.61  E-value: 1.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   5 FVRTGIHFSSSQQALEHIGAEMLARGVVHD--SYPAALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDMPV 82
Cdd:COG1762   11 LILLDLEASSKEEAIEELAELLAEKGYVLDkeEYLEALLEREELGSTGIG---PGIAIPHARPEGVKKPGIAVARLKEPV 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489007542  83 SFQRADDDgeiDVSLIIALIV--ENPAAQLKLLRRLFSELQNPHTLEALLAASD 134
Cdd:COG1762   88 DFGAMDGE---PVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKS 138
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
5-134 4.68e-21

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 83.02  E-value: 4.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542    5 FVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIaleKHAVAIPHCEAIHAKSPAIYLIRPDMPVSF 84
Cdd:pfam00359   6 LIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLKEPVDF 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489007542   85 qraDDDGEIDVSLIIALIV-ENPAAQLKLLRRLFSELQNPHTLEALLAASD 134
Cdd:pfam00359  83 ---GSEDGKPVKLIFLLAApDNEASHLKILSQLARLLQDEEFVEKLLKAKD 130
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 2-129 5.44e-07

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 46.11  E-value: 5.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542    2 SQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPA--ALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPD 79
Cdd:TIGR00848   3 NKDLIFLDQQFTSKEDVIKFLANKLLENGYISDTEEFleDLLKREEEGTTGIG---DGVAIPHAKSAAVKQPFVAIARLV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489007542   80 MPVSFQraDDDGEiDVSLIIALIVENPAAQ---LKLLRRLFSELQNPHTLEAL 129
Cdd:TIGR00848  80 KGVDWQ--SLDGK-PVKLIFLIAVPKDEAGnthLKALSQLARLLLNDEFRAKL 129
 
Name Accession Description Interval E-value
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
1-150 2.12e-95

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 272.06  E-value: 2.12e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   1 MSQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIALEKHAVAIPHCEAIHAKSPAIYLIRPDM 80
Cdd:PRK09665   1 MSNLFVRTGISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIHAKSPAIYLIRPDK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542  81 PVSFQRADDDGEIDVSLIIALIVENPAAQLKLLRRLFSELQNPHTLEALLAASDDRLPVRFQQLILEPEL 150
Cdd:PRK09665  81 KVHFQQADDDNDVAVSLVIALIVENPQQQLKLLRCLFGKLQQPDIVETLLTLPETQLKEYFTKYVLDSDE 150
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 1-135 3.03e-29

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 103.80  E-value: 3.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   1 MSQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDM 80
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIG---NGIAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489007542  81 PVSFqraDDDGEIDVSLIIALIVENPAAQLKLLRRLFSELQNPHTLEALLAASDD 135
Cdd:cd00211   78 PVDF---GSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSK 129
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 5-134 1.18e-24

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 92.61  E-value: 1.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542   5 FVRTGIHFSSSQQALEHIGAEMLARGVVHD--SYPAALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDMPV 82
Cdd:COG1762   11 LILLDLEASSKEEAIEELAELLAEKGYVLDkeEYLEALLEREELGSTGIG---PGIAIPHARPEGVKKPGIAVARLKEPV 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489007542  83 SFQRADDDgeiDVSLIIALIV--ENPAAQLKLLRRLFSELQNPHTLEALLAASD 134
Cdd:COG1762   88 DFGAMDGE---PVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKS 138
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
5-134 4.68e-21

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 83.02  E-value: 4.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542    5 FVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPAALLEREATFPTGIaleKHAVAIPHCEAIHAKSPAIYLIRPDMPVSF 84
Cdd:pfam00359   6 LIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLKEPVDF 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489007542   85 qraDDDGEIDVSLIIALIV-ENPAAQLKLLRRLFSELQNPHTLEALLAASD 134
Cdd:pfam00359  83 ---GSEDGKPVKLIFLLAApDNEASHLKILSQLARLLQDEEFVEKLLKAKD 130
PRK09913 PRK09913
PTS fructose transporter subunit IIA;
10-145 1.47e-08

PTS fructose transporter subunit IIA;


Pssm-ID: 182141 [Multi-domain]  Cd Length: 148  Bit Score: 50.66  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542  10 IHFSSSQQALEHIGAEMLARGVVHDSYP--AALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDMPVSFQRA 87
Cdd:PRK09913  13 IQGNGAYSILKQLATIALQNGFITDSHQflQTLLLREKMHSTGFG---SGVAVPHGKSACVKQPFVLFARKAQAIDWQAS 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489007542  88 ddDGEiDVSLIIALIVenPAA----QLKLLRRLFSELQNPHTLEALLAASDDRLPVRFQQLI 145
Cdd:PRK09913  90 --DGE-DVNCWICLGV--PQSgeedQVKIIGTLCRKIIHQDFIHQLKQGDTDQVLALLNQTL 146
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 2-129 5.44e-07

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 46.11  E-value: 5.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542    2 SQLFVRTGIHFSSSQQALEHIGAEMLARGVVHDSYPA--ALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPD 79
Cdd:TIGR00848   3 NKDLIFLDQQFTSKEDVIKFLANKLLENGYISDTEEFleDLLKREEEGTTGIG---DGVAIPHAKSAAVKQPFVAIARLV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489007542   80 MPVSFQraDDDGEiDVSLIIALIVENPAAQ---LKLLRRLFSELQNPHTLEAL 129
Cdd:TIGR00848  80 KGVDWQ--SLDGK-PVKLIFLIAVPKDEAGnthLKALSQLARLLLNDEFRAKL 129
PRK09765 PRK09765
PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional
 12-132 3.50e-06

PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional


Pssm-ID: 182066 [Multi-domain]  Cd Length: 631  Bit Score: 45.50  E-value: 3.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489007542  12 FSSSQQALEHIGAEMLARGVVHD--SYPAALLEREATFPTGIAlekHAVAIPHCEAIHAKSPAIYLIRPDMPVSFQRADD 89
Cdd:PRK09765  18 FTSREEAIHALAQRLAALGKISSteQFLEEVYRRESLGPTALG---EGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489007542  90 DGEIDVSLIIALivenPAAQ-----LKLLRRLFSELQNPHTLEALLAA 132
Cdd:PRK09765  95 PEAVDLIFLLAI----PPNEagtthMQLLTALTTRLADDEIRARIQSA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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