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Conserved domains on  [gi|489004655|ref|WP_002915265|]
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MULTISPECIES: MetQ/NlpA family ABC transporter substrate-binding protein [Klebsiella]

Protein Classification

PBP2_lipoprotein_like_1 domain-containing protein( domain architecture ID 10194447)

PBP2_lipoprotein_like_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBP2_lipoprotein_like_1 cd13600
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ...
 47-276 8.87e-120

Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


:

Pssm-ID: 270318  Cd Length: 228  Bit Score: 342.39  E-value: 8.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  47 TLKIHYEPAmaGEQRIIEYINQHIAPDyGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPV 126
Cdd:cd13600    1 TLKVATNSG--PMTEILEYIAAELAPD-GITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 127 FQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLKNIVGNPHQFVFKELDLLTMP 206
Cdd:cd13600   78 YHWAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLALP 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489004655 207 RALNSVDAAIGYVSQFDAGKVPREKGILFP-PAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLKT 276
Cdd:cd13600  158 RALDDVDLAFGYPSYFDAAGLTPKDGILLEePDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
PRK11556 super family cl32702
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
9-41 9.95e-05

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


The actual alignment was detected with superfamily member PRK11556:

Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 43.24  E-value: 9.95e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 489004655   9 RKARRWPWLAALAVIILLAIAFWWWRGHTQSQQ 41
Cdd:PRK11556   2 KGSRKSRWVIVIVVVIAAIAAFWFWQGRSTSSS 34
 
Name Accession Description Interval E-value
PBP2_lipoprotein_like_1 cd13600
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ...
 47-276 8.87e-120

Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270318  Cd Length: 228  Bit Score: 342.39  E-value: 8.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  47 TLKIHYEPAmaGEQRIIEYINQHIAPDyGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPV 126
Cdd:cd13600    1 TLKVATNSG--PMTEILEYIAAELAPD-GITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 127 FQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLKNIVGNPHQFVFKELDLLTMP 206
Cdd:cd13600   78 YHWAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLALP 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489004655 207 RALNSVDAAIGYVSQFDAGKVPREKGILFP-PAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLKT 276
Cdd:cd13600  158 RALDDVDLAFGYPSYFDAAGLTPKDGILLEePDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
 12-289 9.15e-68

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 211.89  E-value: 9.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  12 RRWPWLAALAVIILLAIAFWWWRGHTQSQQVvfgsTLKIHYEPAMAGEqrIIEYINQHIApDYGLKLEAVGVQDPVQADR 91
Cdd:COG1464    3 KLLALLLALALALALAACGSSSAAAAAADKK----TIKVGATPGPHAE--ILEVVKPELA-KKGIDLEIVEFTDYVQPNE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  92 AVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGL 171
Cdd:COG1464   76 ALADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 172 ISLDPAVEpRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVDAAIGYVSQF-DAGKVPREKGILFPPAPRTFASQLVIGT 250
Cdd:COG1464  156 IKLKDGVG-LLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYAlEAGLDPTKDALFLEDKDSPYANIIVVRE 234

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 489004655 251 PYLSQENIVKLKQAFSDPRIQTWLKTTddplVKDVLVPV 289
Cdd:COG1464  235 DDKDDPAIKKLVEAYQSDEVKKFIEEK----YKGAVVPA 269
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
 55-275 3.86e-39

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 137.01  E-value: 3.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655   55 AMAG-EQRIIEYInQHIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGI 133
Cdd:pfam03180   5 ATPGpHAEILEVA-KPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEPMGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  134 YSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAvEPRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVD 213
Cdd:pfam03180  84 YSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDG-KGLLATVKDITENPKNLKIKELEAAQLPRALDDVD 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489004655  214 AAI---GYVSQfdAGKVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLK 275
Cdd:pfam03180 163 AAVintNYALE--AGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIE 225
TIGR00363 TIGR00363
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ...
 56-270 8.33e-23

lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]


Pssm-ID: 129460  Cd Length: 258  Bit Score: 94.58  E-value: 8.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655   56 MAGEQRIIEYINQHIAPD-YGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIY 134
Cdd:TIGR00363  25 ISGAEQQVAEVAAKVAKEkYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGYKLVAVGNTFVYPLAGY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  135 SDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLkNIVGNPHQFVFKELDLLTMPRALNSVDA 214
Cdd:TIGR00363 105 SKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVL-DIVENPKKLNITELETSQLPRALDDPKV 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489004655  215 AIGYVSQFDAGKV---PREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRI 270
Cdd:TIGR00363 184 DLAVINTTYAGQVglnPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEV 242
PRK09861 PRK09861
lipoprotein NlpA;
59-270 1.73e-22

lipoprotein NlpA;


Pssm-ID: 182119  Cd Length: 272  Bit Score: 93.93  E-value: 1.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  59 EQRIIEYINQHIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYSDRY 138
Cdd:PRK09861  43 EQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 139 SSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLkNIVGNPHQFVFKELDLLTMPRALN--SVDAAI 216
Cdd:PRK09861 123 KTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL-DITDNPRHLQIMELEGAQLPRVLDdpKVDVAI 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489004655 217 ---GYVSQfdAGKVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRI 270
Cdd:PRK09861 202 istTYIQQ--TGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEV 256
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
9-41 9.95e-05

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 43.24  E-value: 9.95e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 489004655   9 RKARRWPWLAALAVIILLAIAFWWWRGHTQSQQ 41
Cdd:PRK11556   2 KGSRKSRWVIVIVVVIAAIAAFWFWQGRSTSSS 34
TPR1 COG4649
TPR-like repeat domain [Function unknown];
7-48 7.97e-03

TPR-like repeat domain [Function unknown];


Pssm-ID: 443687 [Multi-domain]  Cd Length: 222  Bit Score: 36.77  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489004655   7 ELRK------ARRW-PWLAALAVIILLAIA-FWWWRGHTQSQQVVFGSTL 48
Cdd:COG4649   14 ELRRdrlralWRRYgPWIIGAAVLVVVGVAgWRGWRYWQEAQAEAAGDAY 63
 
Name Accession Description Interval E-value
PBP2_lipoprotein_like_1 cd13600
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ...
 47-276 8.87e-120

Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270318  Cd Length: 228  Bit Score: 342.39  E-value: 8.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  47 TLKIHYEPAmaGEQRIIEYINQHIAPDyGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPV 126
Cdd:cd13600    1 TLKVATNSG--PMTEILEYIAAELAPD-GITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 127 FQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLKNIVGNPHQFVFKELDLLTMP 206
Cdd:cd13600   78 YHWAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLADIVTNPKNLKFTEVDLLALP 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489004655 207 RALNSVDAAIGYVSQFDAGKVPREKGILFP-PAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLKT 276
Cdd:cd13600  158 RALDDVDLAFGYPSYFDAAGLTPKDGILLEePDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
 12-289 9.15e-68

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 211.89  E-value: 9.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  12 RRWPWLAALAVIILLAIAFWWWRGHTQSQQVvfgsTLKIHYEPAMAGEqrIIEYINQHIApDYGLKLEAVGVQDPVQADR 91
Cdd:COG1464    3 KLLALLLALALALALAACGSSSAAAAAADKK----TIKVGATPGPHAE--ILEVVKPELA-KKGIDLEIVEFTDYVQPNE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  92 AVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGL 171
Cdd:COG1464   76 ALADGEIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 172 ISLDPAVEpRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVDAAIGYVSQF-DAGKVPREKGILFPPAPRTFASQLVIGT 250
Cdd:COG1464  156 IKLKDGVG-LLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYAlEAGLDPTKDALFLEDKDSPYANIIVVRE 234

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 489004655 251 PYLSQENIVKLKQAFSDPRIQTWLKTTddplVKDVLVPV 289
Cdd:COG1464  235 DDKDDPAIKKLVEAYQSDEVKKFIEEK----YKGAVVPA 269
PBP2_lipoprotein_MetQ_like cd13526
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ...
 42-275 3.42e-39

The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270244  Cd Length: 228  Bit Score: 137.06  E-value: 3.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  42 VVFGSTlkihyepAMAGEQrIIEYINQHIAPDyGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALS 121
Cdd:cd13526    2 LKIGVT-------AGPSAD-VVEAAKKEAKKK-GYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 122 TTVPVFQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLKnIVGNPHQFVFKELD 201
Cdd:cd13526   73 KVGKTVIAPIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATVLD-ITENPKNLEIVEVD 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489004655 202 LLTMPRALNSVDAAIGYVSQFD-AGKVPREKGILFPPAPRT-FASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLK 275
Cdd:cd13526  152 AAQLPRSLDDVDAAVINGNYAIsAGLDPRKDAIFLEDSDASpYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLK 227
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
 55-275 3.86e-39

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 137.01  E-value: 3.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655   55 AMAG-EQRIIEYInQHIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGI 133
Cdd:pfam03180   5 ATPGpHAEILEVA-KPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEPMGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  134 YSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAvEPRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVD 213
Cdd:pfam03180  84 YSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDG-KGLLATVKDITENPKNLKIKELEAAQLPRALDDVD 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489004655  214 AAI---GYVSQfdAGKVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLK 275
Cdd:pfam03180 163 AAVintNYALE--AGLNPKKDALFEEDKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIE 225
PBP2_lipoprotein_IlpA_like cd13598
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ...
 56-276 7.46e-39

Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270316  Cd Length: 227  Bit Score: 135.94  E-value: 7.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  56 MAGEQRIIEYINQHIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYS 135
Cdd:cd13598    7 IRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVYPIGLYS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 136 DRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEpRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVDAA 215
Cdd:cd13598   87 KKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGVG-LLATVRDIAENPKKLKIVELDAGQLPRALDDVDLA 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489004655 216 I---GYVSQfdAGKVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLKT 276
Cdd:cd13598  166 AintDYASK--AGLTPARDAIAQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
PBP2_lipoprotein_Tp32 cd13597
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ...
 47-277 6.87e-38

The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270315  Cd Length: 236  Bit Score: 133.94  E-value: 6.87e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  47 TLKIHYEPAMAGEqrIIEYINQHIAPDyGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPV 126
Cdd:cd13597    1 TLKVGATPVPHAE--ILEFIKPELKKQ-GIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 127 FQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPrTAKLKNIVGNPHQFVFKELDLLTMP 206
Cdd:cd13597   78 HLEPMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGL-TATVKDIVKNPKNLKFKELEAAQLP 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489004655 207 RALNSVDAAI---GYVSQfdAGKVPREKGILF-PPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRIQTWLKTT 277
Cdd:cd13597  157 RSLDDVDAAVingNYALE--AGLNPKKDALALeDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEK 229
PBP2_lipoprotein_GmpC cd13596
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ...
 47-271 1.75e-30

The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270314  Cd Length: 230  Bit Score: 114.38  E-value: 1.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  47 TLKIhyepAMAGEQ-RIIEYINQhIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVP 125
Cdd:cd13596    1 TVKI----GVTGEDtDIWDKIVE-EAEEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 126 VFQWAFGIYSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPrTAKLKNIVGNPHQFVFKELDLLTM 205
Cdd:cd13596   76 TVIAPMGIYSKKITSVDELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKKDAGD-FPTVNDITENPKNLEIVPVDADQV 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489004655 206 PRALNSVDAA-IGYVSQFDAGKVPREKgILFPPAPRTFASQLVIGTPYLSQEN-----IVKLKQAFSDPRIQ 271
Cdd:cd13596  155 YRALNDVDAAvINNTFALDAGLDPKKD-AIFLEDPSSYGSKPYINLIAVREEDkdnplYKKLVETYHDERVQ 225
PBP2_lipoprotein_Gna1946 cd13599
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ...
 75-216 5.17e-29

The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270317  Cd Length: 228  Bit Score: 110.18  E-value: 5.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  75 GLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYSDRYSSVQALPNGATIVVPD 154
Cdd:cd13599   27 GYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPTPPMGLYSNKHKSLEEVKDGATVAIPN 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489004655 155 DGANQGQALWLLQRIGLISLDPAVEPRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVDAAI 216
Cdd:cd13599  107 DPSNLARALVMLQDLGWITLKDNIDPLKASVNDIAENPKNIKIVELEAAQLPRSLDDVDFAA 168
TIGR00363 TIGR00363
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ...
 56-270 8.33e-23

lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]


Pssm-ID: 129460  Cd Length: 258  Bit Score: 94.58  E-value: 8.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655   56 MAGEQRIIEYINQHIAPD-YGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIY 134
Cdd:TIGR00363  25 ISGAEQQVAEVAAKVAKEkYGLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDAKAKGYKLVAVGNTFVYPLAGY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  135 SDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLkNIVGNPHQFVFKELDLLTMPRALNSVDA 214
Cdd:TIGR00363 105 SKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLKDGNGLLPTVL-DIVENPKKLNITELETSQLPRALDDPKV 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489004655  215 AIGYVSQFDAGKV---PREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRI 270
Cdd:TIGR00363 184 DLAVINTTYAGQVglnPQDDGVFVEDKDSPYVNIIVSREDNKDAENVKDFIQSYQSEEV 242
PRK09861 PRK09861
lipoprotein NlpA;
59-270 1.73e-22

lipoprotein NlpA;


Pssm-ID: 182119  Cd Length: 272  Bit Score: 93.93  E-value: 1.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  59 EQRIIEYINQHIAPDYGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGIYSDRY 138
Cdd:PRK09861  43 EQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 139 SSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEPRTAKLkNIVGNPHQFVFKELDLLTMPRALN--SVDAAI 216
Cdd:PRK09861 123 KTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTAL-DITDNPRHLQIMELEGAQLPRVLDdpKVDVAI 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489004655 217 ---GYVSQfdAGKVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAFSDPRI 270
Cdd:PRK09861 202 istTYIQQ--TGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEV 256
metQ PRK11063
D-methionine ABC transporter substrate-binding protein MetQ;
56-265 3.45e-21

D-methionine ABC transporter substrate-binding protein MetQ;


Pssm-ID: 182939 [Multi-domain]  Cd Length: 271  Bit Score: 90.59  E-value: 3.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655  56 MAG-EQRIIEyINQHIAPD-YGLKLEAVGVQDPVQADRAVAEGQYAGTIYQHQWWLKQVVDANGFALSTTVPVFQWAFGI 133
Cdd:PRK11063  38 IVGaEQQVAE-VAQKVAKEkYGLDVELVTFNDYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489004655 134 YSDRYSSVQALPNGATIVVPDDGANQGQALWLLQRIGLISLDPAVEpRTAKLKNIVGNPHQFVFKELDLLTMPRALNSVD 213
Cdd:PRK11063 117 YSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVG-LLPTVLDIVENPKNLKIVELEAPQLPRSLDDAQ 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489004655 214 AAIG-----YVSQFDAgkVPREKGILFPPAPRTFASQLVIGTPYLSQENIVKLKQAF 265
Cdd:PRK11063 196 IALAvinttYASQIGL--TPAKDGIFVEDKDSPYVNLIVAREDNKDAENVKKFVQAY 250
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
9-41 9.95e-05

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 43.24  E-value: 9.95e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 489004655   9 RKARRWPWLAALAVIILLAIAFWWWRGHTQSQQ 41
Cdd:PRK11556   2 KGSRKSRWVIVIVVVIAAIAAFWFWQGRSTSSS 34
TPR1 COG4649
TPR-like repeat domain [Function unknown];
7-48 7.97e-03

TPR-like repeat domain [Function unknown];


Pssm-ID: 443687 [Multi-domain]  Cd Length: 222  Bit Score: 36.77  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 489004655   7 ELRK------ARRW-PWLAALAVIILLAIA-FWWWRGHTQSQQVVFGSTL 48
Cdd:COG4649   14 ELRRdrlralWRRYgPWIIGAAVLVVVGVAgWRGWRYWQEAQAEAAGDAY 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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