|
Name |
Accession |
Description |
Interval |
E-value |
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-448 |
0e+00 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 938.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 1 MLSIFKPAAHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQGFSRGDLGFALSGISIAYGFSK 80
Cdd:PRK11273 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 81 FIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:PRK11273 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 161 WNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNDYPDDYSEKHEEELT 240
Cdd:PRK11273 161 WNCAHNVGGGLPPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQELT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 241 AKQIFMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGN 320
Cdd:PRK11273 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 321 RGATGVFFMTLVTIATVVYWLNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:PRK11273 321 RGATGVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489002380 401 SAIVGYTVDFFGWDGGFMVMIGGSVLAVILLVIVMLGERRHHQQLKQA 448
Cdd:PRK11273 401 SAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQK 448
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
3-440 |
0e+00 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 786.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 3 SIFKPAAHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQGFSRGDLGFALSGISIAYGFSKFI 82
Cdd:TIGR00712 1 SIFKPAPHIARLPAAKIDPTYKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSKGELGFALSAISIAYGFSKFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 83 MGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN 162
Cdd:TIGR00712 81 MGSVSDRSNPRVFLPAGLILSAAVMLLMGFVPWATSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 163 CAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNDYPDDYSEKHEEELTAK 242
Cdd:TIGR00712 161 CAHNIGGGIPPLLVLLGMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIEEYRNDYPDDYNEKAEQELTAK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 243 QIFMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRG 322
Cdd:TIGR00712 241 EIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 323 ATGVFFMTLVTIATVVYWLNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 402
Cdd:TIGR00712 321 ATGVFFMTLVTIAVIVYWMNPAGNPLVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 489002380 403 IVGYTVDFFGWDGGFMVMIGGSVLAVILLVIVMLGERR 440
Cdd:TIGR00712 401 IVGYTVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKR 438
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-435 |
0e+00 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 617.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQyGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND 185
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 --WHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNDYPDDY-SEKHEEELTAKQIFMQYILPNKLLWYIAIAN 262
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEAdGEEEEQELSAWEIFVKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLN 342
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 343 PpgNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIG 422
Cdd:cd17345 321 P--NVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLLA 398
|
410
....*....|...
gi 489002380 423 GSVLAVILLVIVM 435
Cdd:cd17345 399 SCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-417 |
1.94e-176 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 498.44 E-value: 1.94e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 35 FFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFV 113
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEiGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 114 PwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMP 193
Cdd:TIGR00881 81 T----SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 194 AFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNDYPDDYSEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 274 DWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNPPGNPGVDMAC 353
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489002380 354 MIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSvAASAIVGYTVDFFGWDGGF 417
Cdd:TIGR00881 317 LFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGI-LAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-435 |
1.21e-124 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 366.21 E-value: 1.21e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEiGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFvpwaTSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:cd17312 81 ANIFMGF----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY-G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFAMMRDTPqscglppieeykndypddysekheeeltakqifmqyilpnKLLWYIAIANVFV 265
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSP----------------------------------------PYVWVLSLAYAFV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNpPG 345
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFF-PH 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 346 NPGVDMACMIIIGFLIYGPVMLIGLHALE-LAPKKAAGTAAGFTGLFGYLGGSVAASaIVGYTVDFFGWDGGFMVMIGGS 424
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGL-PLGYIIDHYGWSTVFYFLISAA 353
|
410
....*....|.
gi 489002380 425 VLAVILLVIVM 435
Cdd:cd17312 354 LLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
16-431 |
1.25e-101 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 310.10 E-value: 1.25e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 16 AAEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLI-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRI 94
Cdd:PRK11663 10 KHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLaDLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 95 FLPAGLILAALVMLVMGFvpwatSSIMIMFVLLF-LCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPP 173
Cdd:PRK11663 90 FMGIGLIATGIINILFGF-----SSSLWAFALLWvLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 174 LLflLGMAWFN-DWHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNDYPDDYSEKHEEELTAKQIFMQYILPN 252
Cdd:PRK11663 165 LV--VGAIALHyGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEILTKYVLLN 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 253 KLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLV 332
Cdd:PRK11663 243 PYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 333 TIATVVYWLNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIvGYTVDFFG 412
Cdd:PRK11663 323 LLSVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPL-AKVLEIWH 401
|
410 420
....*....|....*....|
gi 489002380 413 WDGGFMVM-IGGSVLAVILL 431
Cdd:PRK11663 402 WTGFFVVIsIAAGISALLLL 421
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
13-447 |
3.03e-85 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 268.84 E-value: 3.03e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 13 RLPAAEIDPLYRRLRW-----QIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSV 86
Cdd:PRK09556 8 RKPTLDLPLEVQRKMWfkpfmQSYLVVFIGYLTMYLIRKNFKAAQNDMISTyGLSTTELGMIGLGFSITYGVGKTLVGYY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 87 SDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIM-IMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAH 165
Cdd:PRK09556 88 ADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLgLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISH 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 166 NVGGGIPPLLFLLGMAWFNDWHAA--LYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEE-YKNDYPDDYSEKHEEELTAK 242
Cdd:PRK09556 168 NLGGAGAGGVALWGANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEiFGEPISEEDKETESTDMTKW 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 243 QIFMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfKGNRG 322
Cdd:PRK09556 248 QIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 323 ATGVFFMTLVTIATVVYwlNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASA 402
Cdd:PRK09556 327 LVACIALALIIFTLGVY--QHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFAKV 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 489002380 403 IVGYTVD------------FFGWDGGFMVMIGGSVLAVILLVIVMLGERRHHQQLKQ 447
Cdd:PRK09556 405 GLGMIADptkngtpifgytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKK 461
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
27-431 |
4.23e-85 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 265.04 E-value: 4.23e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLI-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLaDLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFvpwaTSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17488 81 INILFGF----SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFAMMRDTPQscglppieeykndypddysekheeeltakqifmqyilpnkLLWYIAIANVFV 265
Cdd:cd17488 156 WRAGMYVPGIIAILMGIVLCWRLRDRPP----------------------------------------YIWLLAFCYVLV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNPPG 345
Cdd:cd17488 196 YVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVH 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 346 NPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGGSV 425
Cdd:cd17488 276 SYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAAL-AGYPLAKVIESWGWSGFFIVISIAAA 354
|
....*.
gi 489002380 426 LAVILL 431
Cdd:cd17488 355 ISGLLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-440 |
7.31e-69 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 223.21 E-value: 7.31e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 20 DPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPA 98
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 99 GLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLL 178
Cdd:COG2271 81 GLLLWGLATLLFGFAT----SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 179 GMAWFnDWHAALYMPAFGAILLAIFAFammrdtpqscglppieeykndypddysekheeeltakqifmqyilpnkllWYI 258
Cdd:COG2271 157 LLAAF-GWRAAFLILGLPGLLLALLRF--------------------------------------------------WLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 259 AIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRgATGVFFMTLVTIATVV 338
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-LVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 339 YWLNPpgNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFM 418
Cdd:COG2271 265 LALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL-GPLLVGYLLDATGYQAAFL 341
|
410 420
....*....|....*....|..
gi 489002380 419 VMIGGSVLAVILLVIVMLGERR 440
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
27-432 |
2.58e-54 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 186.39 E-value: 2.58e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLI-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMnELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGfvpwATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLgMAWFND 185
Cdd:cd17343 81 TTVAFS----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATL-LALSYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEykndypdDYSEKHEEELTAKQIFMQYILPNKLLWYIAIANVFV 265
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE-------EESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDK-VFKGNRGATGVFFMTLVT-----IATVVY 339
Cdd:cd17343 229 FGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWaVAKHGSSSRGNPRMPLALvfmagLTVSLH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 340 WLNPPGNPGVDMACMIIIGFLI----YGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFGWDG 415
Cdd:cd17343 309 LFRVHITSDSSELFILLLGFLIgfslYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGG-VLAGLPFSYIAKHYDWRT 387
|
410
....*....|....*..
gi 489002380 416 GFMVMIGGSVLAVILLV 432
Cdd:cd17343 388 AFLLLEILCAITVVILF 404
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-432 |
6.15e-40 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 147.19 E-value: 6.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 34 IFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGF 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSfGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 113 VPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWF-NDWHAALY 191
Cdd:cd06174 81 AP----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 192 MPAFGAILLAIFAFAMMRDTPQSCGlppieeykndypddySEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLRYG 271
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESAR---------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 272 ILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKvfkgNRGATGVFFMTLVTIATVVYWLNPPGNPGVDM 351
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----LIGRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 352 ACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSVLAVILL 431
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 489002380 432 V 432
Cdd:cd06174 378 L 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-434 |
6.88e-34 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 130.38 E-value: 6.88e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDlGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFVpwatSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17319 81 FTALTGFA----TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFAMMRdtpqscglppieeykndypddysekheeeltakqifmqyilpnkLLWYIAIANVFV 265
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYLR--------------------------------------------QVWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNppG 345
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--T 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 346 NPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFG-WDGGFMVMIGGS 424
Cdd:cd17319 270 SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV-APLLIGYLVDATGsYTAAFLFLAAVA 348
|
410
....*....|
gi 489002380 425 VLAVILLVIV 434
Cdd:cd17319 349 LLAALLVLLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-431 |
1.34e-28 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 115.80 E-value: 1.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 35 FFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFV 113
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDlHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 114 pwatSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLfLLGMAWFNDWHAALYMP 193
Cdd:cd17475 82 ----GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL-LPPLALHYGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 194 AFGAILLAIFAFAMMRDTPQSCGLPPIEEykndypddysekhEEELTAKQIfmqyiLPNKLLWYIAIANVFVYLLRYGIL 273
Cdd:cd17475 157 GLVSILAAVLFWLFYREPPAASAATESAS-------------TLLRSLKEV-----LRNRDVWLIAIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 274 DWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNPPGNP-GVDMA 352
Cdd:cd17475 219 TFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPlWLLVL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 353 CMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFMVMIGGSVLAVILL 431
Cdd:cd17475 299 LLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALLL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-443 |
4.22e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 114.59 E-value: 4.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnD 185
Cdd:COG2223 83 GLLLLALAV----SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-G 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFAMMRDTPqscglppieeykndypddysekHEEELTAKQIFMQY--ILPNKLLWYIAIANV 263
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP----------------------AGAAAAAKASLRDQleALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 264 FVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgnRGATGVFFMTLVTIATVVYWLNP 343
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFALMALGLLLLALA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 344 PGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFG-WDGGFMVMIG 422
Cdd:COG2223 292 LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLLFGALLDATGsYTAAFLVFAV 370
|
410 420
....*....|....*....|.
gi 489002380 423 GSVLAVILLVIVMLGERRHHQ 443
Cdd:COG2223 371 LALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-400 |
8.79e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.90 E-value: 8.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 34 IFFGYAAYYLVRKNFALAMPYLI--EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMG 111
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 112 FvpwaTSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALY 191
Cdd:pfam07690 81 F----ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 192 MPAFGAILLAIFAFammrdtpqscglppieeYKNDYPDDYSEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLRYG 271
Cdd:pfam07690 156 ILAILSLLAAVLLL-----------------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 272 ILDWSPTYLkEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIAtvVYWLNPPGNPGVDM 351
Cdd:pfam07690 219 LLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG--LLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489002380 352 ACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-399 |
8.02e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.67 E-value: 8.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 24 RRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLIL 102
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 103 AALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAW 182
Cdd:COG2814 85 FALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 183 FnDWHAALYMPAFGAILLAIFAFAMMRDTPQSCGLPPIEEYKNdypddysekheeeltakqifmqyILPNKLLWYIAIAN 262
Cdd:COG2814 161 F-GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-----------------------LLRRPRLLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgnrGATGVFFMTLVTIATVVYWLN 342
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489002380 343 PPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVA 399
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-444 |
5.71e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 88.37 E-value: 5.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 24 RRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLIL 102
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAfGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 103 AALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGrTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAW 182
Cdd:COG0738 83 MALGLLLFALAP----SYPLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 183 FNDWHAALYMPAFGAILLAIFAFAMMRDTPQscglppieeykndypddySEKHEEELTAKQIFMQYILPNKLLWYIAIAN 262
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLPE------------------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 263 VFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLN 342
Cdd:COG0738 220 FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 343 PpgNPGVDMACMIIIGFLIyGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIg 422
Cdd:COG0738 297 P--GPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAI-GPPLIGFLADAFGLRAAFLVPL- 371
|
410 420
....*....|....*....|..
gi 489002380 423 gsVLAVILLVIVMLGERRHHQQ 444
Cdd:COG0738 372 --VCYLLILLLALALKRKRRKK 391
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-432 |
1.19e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 81.19 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 31 FIGIFFGYAAYYLVRKNFALAMPYLI-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLV 109
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIaEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 110 MGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAA 189
Cdd:cd17371 81 CGFAQ----NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 190 LYMPAFGaILLAIFAFAMMRDTPQscglPPIeeykndypddYSEKHEEELTAKQIFMQYILPNK------LLWyiAIANV 263
Cdd:cd17371 157 RVLFLLG-ALPALLVLFIRRFVKE----PPQ----------WQAARAARRHFADRPSLRELFSPpllrttLLA--SLLAT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 264 FVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkGNRGATGVFFMtlVTIATVVYWLNP 343
Cdd:cd17371 220 GALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI--GRRNNFALFAL--GSAISILLYFFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 344 PGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMVMIGG 423
Cdd:cd17371 296 PLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGAL-FPFLVGFLATSGSLGTAIAVFAAV 374
|
....*....
gi 489002380 424 SVLAVILLV 432
Cdd:cd17371 375 YYIAGLVLA 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-435 |
7.09e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 78.75 E-value: 7.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 52 MPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLC 130
Cdd:cd17478 19 LPLLIAKlGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP----NYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 131 GWFQGMGWPPcGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLfllgMAWFNDWHAALYMPAFGAILLAIFAFAMMRd 210
Cdd:cd17478 95 GIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLI----AAALVALFGGLGLLILLIIPGLAVALLLLR- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 211 tpqscglppieeykndYPDDYSEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDK 290
Cdd:cd17478 169 ----------------LRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 291 SSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLNPpgnPGVDMACMIIIGFLIYGPVMLIGL 370
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDRF---GRRRVIIASLLLAAPFLLLFLLTP---GIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489002380 371 HALELAPKKaAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMiggSVLAVILLVIVM 435
Cdd:cd17478 306 LAQELLPGN-VGLASGLMMGLSFGLGGIGA-PVLGALADAFGLESVLLIL---ALLPLLGALLAF 365
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
30-432 |
9.05e-16 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 78.90 E-value: 9.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 30 IFIGIFFGYAAYYLVRKNFALAMPYLIEQGFSRGD--------------------------LGFALSGISIAYGFSKFIM 83
Cdd:cd17342 4 VFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSntsielheetwnanplfpsqddaalfLGVLDTIFLFSYAIGLFIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 84 GSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATS--SIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVW 161
Cdd:cd17342 84 GWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 162 NCAHNVGGGIPPLlfLLGMAWFNDWHAALYMPAFGAILLAIFAFammrdtpqsCGLPPIeeykndypddysekheeelta 241
Cdd:cd17342 164 SACASVGNIIGAL--LASSVLDYGYEYAFLVTSSLLFAGAIVVF---------FGLLSS--------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 242 kqifmqyilPNKLLWYiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkGNR 321
Cdd:cd17342 212 ---------PPGVIPY-SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRM--GSR 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 322 GATGVFFMTLVTIATVVYwLNPPGNPGVDMACMIIIGFLIYGPVMLI--------GLHALELAPKKAAGTAAGFTGLFGY 393
Cdd:cd17342 280 SPVVVVMLLLAIPSLFVY-SHSPSDKVLNAFVMTITGFFIGGPANLIssaisadlGRQPQLRGSSEALATVTGIIDGTGS 358
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 489002380 394 LGGSVaASAIVGYTVDFFGWDG---GFMVMIGGSVLAVILLV 432
Cdd:cd17342 359 IGAAI-GQVLVPLIQNRLGWMWvfyFFIIMTILTIVCILPLL 399
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
27-438 |
2.07e-14 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 74.66 E-value: 2.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVRK-----------NFALAMPYLIEQGFSRGDLGFA----------LSGIS----IAYGFSKF 81
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKpisivksvlhpNCSALIPPPNIVLNNTTWCGWApfdgkngtelLGALDsaflFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 82 IMGSVSDRSNPRIFLPAGLILAALVMLVMGF-VPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLgYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 161 WNcAHNVGGGIppLLFLLGMAWFN-DWHAALYMPAFGAILLAIFAFAMMRDTPqscglPPIEEYkndypddysekheeel 239
Cdd:cd17344 161 WN-SHTSVGNI--LGSLIAGIFVSsAWGLSFIVPGIIIAAMGVLVFLFLVEHP-----PGVIEF---------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 240 takqifmqyilpnkllwyiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkG 319
Cdd:cd17344 217 -------------------SLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYT--G 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 320 NRGATGVFFMTLVTIATVVYWLNPPGNPGVDMACMIIIGFLIYGPVMLI--------GLHALELAPKKAAGTAAGF---T 388
Cdd:cd17344 276 GRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALIttavsadlGTHKSLKGNARALATVTAIidgT 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 489002380 389 GLFGYLGGSVAASAIVGYtvdffGWDGGFMVMIGGSVLAVILLVIVMLGE 438
Cdd:cd17344 356 GSIGAALGPLLAGLISSR-----GWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
57-434 |
3.78e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.75 E-value: 3.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGM 136
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 137 GwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFGAILLAIFAFAMMRDTPqscg 216
Cdd:COG2807 123 G-NVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-GWRGALAVWALLALLALLLWLPLLRRRP---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 217 lppieeykndypddysekHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKHFALDKSSWAYF 296
Cdd:COG2807 197 ------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 297 LYEYAGIPGTLLCGWMSDKVfkGNRGATGVFFMTLVTIATVVYWLNPPGNPgvdMACMIIIGFLIYGPVMLIGLHALELA 376
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 377 PKKA-AGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFG-WDGGFMVMIGGSVLAVILLVIV 434
Cdd:COG2807 333 RTPAeAAALSGMAQSVGYLLAALGP-LLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-436 |
6.33e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.40 E-value: 6.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 24 RRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRI-----FL 96
Cdd:COG2211 5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 97 PAGLILAALVMLVMGFVPWA--TSSIMIMFVLLFLCGWFQGMGWPPcgrtmvhWWS--------QKERGGIVSVWNCAHN 166
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLspTGKLIYALVTYLLLGLAYTLVNIP-------YSAlgaeltpdYEERTRLSSWRFAFAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 167 VGGGIPPLLFLLGMAWFNDWHAA--LYMPAFGAILLAIFAFAMMRDTPqscglppieeykndypdDYSEKHEEELTAKQI 244
Cdd:COG2211 158 LGGLLASVLPPPLVAAFGGDAALgyRLTALIFAVLGLLAFLLTFFGTK-----------------ERPVPEEEKVSLKES 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 245 FmQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkGNRGAT 324
Cdd:COG2211 221 L-KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAF 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 325 gVFFMTLVTIATVVYWLNPPGNPGVDMACMIIIGFLiYGPVMLIGL--------HALELAPKKAAGTAAGFTGLFGYLGG 396
Cdd:COG2211 298 -IIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIG-LGAILVLPWamladvvdYDEWKTGRRREGLYFGIFTFAIKLGQ 375
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 489002380 397 SVAAsAIVGYTVDFFGWDGG--------FMVMIGGSVLAVILLVIVML 436
Cdd:COG2211 376 ALAG-ALAGLLLALFGYVAGaaqspsalTGIRLLFFLLPAVLLLLAAL 422
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-432 |
7.24e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 72.63 E-value: 7.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 31 FIGIFFGYAAYYLVRKNFALAMPYLIE---QGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVM 107
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 108 LVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd17316 81 LLIGLLP----TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 188 AALYMPAFGAILLAIFAFAMMRdtpqscglppieeykndypddysekheeeltakqifmqyilpnklLWYIAIANVFVYL 267
Cdd:cd17316 157 GWRILFLIGALPALLALLLRRR---------------------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 268 LRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLNPPGNP 347
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 348 GVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSVLA 427
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
....*
gi 489002380 428 VILLV 432
Cdd:cd17316 349 LIVAL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-433 |
6.26e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.91 E-value: 6.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 30 IFIGIFFGYAAYYLVRKNFALampYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLV 109
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL---YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 110 MGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLgMAWFNDWHAA 189
Cdd:cd17325 78 FAFAT----SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRAP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 190 LYMPAFGAILLAIFAFAMMRDTPQScglppieeykndypddySEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLLR 269
Cdd:cd17325 153 FLVCAALALLALVLALLLLPEPRPP-----------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 270 YGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgnrGATGVFFMTLVTIATVVYWLNPPGNPGV 349
Cdd:cd17325 216 GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-----GRKPLILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 350 DMACMIIIGFL--IYGPVMLigLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSVLA 427
Cdd:cd17325 291 LLLLLALLGLGlgLVFPATL--ALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367
|
....*.
gi 489002380 428 VILLVI 433
Cdd:cd17325 368 AVLFLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
52-434 |
4.08e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.30 E-value: 4.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 52 MPYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMgfvPWATSSIMIMFVLLFLCG 131
Cdd:cd17355 27 IPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL---ALATSLWQLYLLWGLLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 132 WFQGMGWPPCGRTMVHWWSQKERG---GIVSvwncahnVGGGIPPLLFLLGMAWFND---WHAALYMPAFGAILLAIFAF 205
Cdd:cd17355 104 GGAGTLAAVAFATVAAWWFERRRGlalGILT-------AGGGLGSLVFLPLGAALIEafgWRTALLVLALLALLVLVPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 206 AMMRDTPQSCGLPpieeykndyPDDYSEKHEEELTAKQIFMqyilpNKLLWYIAIANVFVYLLRYGILDWSPTYLKEvKH 285
Cdd:cd17355 177 LLLRRRPADLALR---------AYDDASPASPGSTLKEALR-----SASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 286 FALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLNPPGNPGVDMACMiIIGFLIYGPV 365
Cdd:cd17355 242 ISPAAAAVALALIGLFNIVGRLLSGWLGDRY---SPRRLLAASYALRALGLALLLLLPFPPLALLLFAA-LFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489002380 366 MLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAiVGYTVDFFGWDGGFMVMIGGSVLAVILLVIV 434
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL-GGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
27-435 |
7.31e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.32 E-value: 7.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGIFFGYAAYYLVrknFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMV---WPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFVpwatSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL-FLLGMAWFN 184
Cdd:cd17329 78 GFALLGFA----HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLYSFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 185 dwhaalYMPAFGAILLAIFAFAMMRdtpqscGLPPIEeykndyPDDYSEKHEEELTAKQIFMQyilpNKLLWYIAIANVF 264
Cdd:cd17329 154 ------LLFLAAAVLFLLAALVLLF------LLPETR------PKRRAAEKTEILRGYKIVLR----DRAFLLFLLASFL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 265 VYLLRYGILDWSPTYLKEVKHFALDKSSWayfLYEYAGIPGTLLCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLnpP 344
Cdd:cd17329 212 ISLIYFQLESTLPVYVVEILGLGESLLGL---LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF--A 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 345 GNPGVDMACMII--IGFLIYGPVmlIGLHALELAPKKAAGTAAGFTGLFGYLGGsVAASAIVGYTVDFFGWDGGFMVMIG 422
Cdd:cd17329 287 NTLAVLILAMIVltLGEMLVFPA--VQTLVAALAPPDKRGSYMGFYALAWGLGR-AIGPLVGGLLLDLLGPGLPWLILAA 363
|
410
....*....|...
gi 489002380 423 GSVLAVILLVIVM 435
Cdd:cd17329 364 LGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
66-430 |
1.58e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.49 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 66 GFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTM 145
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 146 vhwwSQKERGGIVSVWNCAhNVGGGI--PPLLFLLGMAWfnDWHAALY-MPAFGAILLAIFAFAMMRDTPQScglppiee 222
Cdd:cd17324 117 ----PPEKRGRAIGLVFSG-LTLGLVlgRPLGGLLGQLL--GWRAAFLaIAVLALLAALLLWRLLPSLPPKK-------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 223 ykndyPDDYSEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVYLlrygildwsPTYLKEVKHFALDKSSWAYFLYEYAG 302
Cdd:cd17324 182 -----PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYL---------APFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 303 IPGTLLCGWMSDKVFKGnrgaTGVFFMTLVTIATVVYWLNPPGNPGVDMAcMIIIGFLIYGPVMLIGLHALELAPkKAAG 382
Cdd:cd17324 248 VVGSPLAGRLADRGGRR----ALLIALLLLAAALLLLTLLGPSPLLLLVG-LVLWGLGFFAAHSALQTRVLRLAP-EARG 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489002380 383 TAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSVLAVIL 430
Cdd:cd17324 322 LASSLYLAAYNLGGALGA-ALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-209 |
1.81e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 12 ARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIeqGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSN 91
Cdd:cd17325 186 ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG--GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 92 PRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI 171
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLAT----SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
170 180 190
....*....|....*....|....*....|....*...
gi 489002380 172 PPLlfLLGMAWFNDWHAALYMPAFGAILLAIFAFAMMR 209
Cdd:cd17325 340 GPL--LGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-208 |
2.16e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 6 KPAAHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQGF--SRGDLGFALSGISIAYGFSKFIM 83
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYgiSPIIIGLLFAGWSVLLALGSLFV 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 84 GSVSD-RSNPRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN 162
Cdd:cd17474 255 GRLLKkRFGARRILVIGLLLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489002380 163 CAHNVGGGIPPLLFLLGMAWFNdwHAALYMPAFGAILLAIFAFAMM 208
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLLEIFG--LSAPFLVGAAIALAAAVLLALL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-172 |
4.41e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.68 E-value: 4.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 7 PAAHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVrknFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 86 VSDRSNPRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAH 165
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
....*..
gi 489002380 166 NVGGGIP 172
Cdd:COG2814 342 FLGGPLA 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-211 |
4.65e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.88 E-value: 4.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 6 KPAAHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVrknFALAMPYLIEQGFSRGDLGFALSGISIAYGFSKFIMGS 85
Cdd:COG2807 196 PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAV---VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 86 VSDRSNPRiflpAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGmGWPPCGRTMV--HWWSQKERGGIVSVWNC 163
Cdd:COG2807 273 LADRLGDR----RPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLIglRARTPAEAAALSGMAQS 347
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 489002380 164 AHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAFAMMRDT 211
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
98-433 |
1.23e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 98 AGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFL 177
Cdd:cd17333 62 RTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIAT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 178 LGMAWFNDWHAALYMPAFGAILLAIFAFAmmrdtpqsCGLPpieeykndyPDDYSEKHEEELTAKQIFMQYILPNKLLWY 257
Cdd:cd17333 141 SLLTSELSWSWAYLIIGLIYLLLAILILL--------TLFP---------ELPSARNPQQSVGAFSASASRLLRNPSIIL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 258 IAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgnRGATGVFFMTLVTIA-T 336
Cdd:cd17333 204 GALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI----KPHTLLVLSGSGALLgL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 337 VVYWLNPpgNPGVDMACMIIIGFLIyGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGG 416
Cdd:cd17333 280 LILLLAP--TLVVGLVATALLGLFM-AALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAI-IPFIMGFIAEAVGIQTA 355
|
330
....*....|....*..
gi 489002380 417 FMVMIGGSVLAVILLVI 433
Cdd:cd17333 356 MLLITILYAIIFVLALL 372
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
24-406 |
1.60e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 24 RRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLI-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLIL 102
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISaEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 103 AALVMLVMGFvpwATSSIMIMfVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAW 182
Cdd:TIGR00895 92 FSVFTLLCAL---ATNVTQLL-ILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 183 FnDWHAALYmpaFGAILLAIFAFAMMRDTPQSC------GLPPIEEYKNDYPDDYSEKHEEEL--------TAKQIFM-- 246
Cdd:TIGR00895 168 F-GWRSLFY---VGGIAPLLLLLLLMRFLPESIdflvskRPETVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKal 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 247 ---QYILPNKLLWYIAIANVFVYllrYGILDWSPTYLKEVKhFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGA 323
Cdd:TIGR00895 244 fqgKTARITVLLWLLYFMLLVGV---YFLTNWLPKLMVELG-FSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 324 TGVFFMTLVTIATVVYwlNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAI 403
Cdd:TIGR00895 317 TALLLLLGAVFAVLVG--STLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP-IL 393
|
...
gi 489002380 404 VGY 406
Cdd:TIGR00895 394 AGY 396
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
27-434 |
1.06e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.69 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 27 RWQIFIGiFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAAL 105
Cdd:cd17353 2 RWLVLLG-AVLMHLILGYQYAWSVFNPPLSSAlGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 106 VMLVMGFvpwATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKeRGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND 185
Cdd:cd17353 81 GFILSAF---AISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 WHAALYMPAFGAILLAIFAFaMMRDTPQSCGLPPIEEYKNDYPDDYSEKHEEELTAKQIFMqyilpnkLLWYIAIANVFV 265
Cdd:cd17353 157 PTTFLILGIIFLIIIVIGAF-LIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFW-------LLWLMFFLNATA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGIldwSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKvFKGNRGATGVFFMTLVTIATVVYWlnpPG 345
Cdd:cd17353 229 GLMLIGQ---AKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK-IGRKNTLSIAFLIQGVAMFLLPFI---GS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 346 NPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTgLFGYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSV 425
Cdd:cd17353 302 VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSL 380
|
....*....
gi 489002380 426 LAVILLVIV 434
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
57-436 |
2.09e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 57 EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFvpwaTSSIMIMFVLLFLCGWFQGM 136
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF----AQSVLQLALLRFLTGLGLGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 137 GWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMPAFGAILLAIFAFAMMrdtpqscg 216
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFLLGGVPPLILLPLLRGTL-------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 217 lppieeykndypddysekheeeltakqifmqyilpnkLLWYIAIANVFVYllrYGILDWSPTYLKEVKhFALDKSSWAYF 296
Cdd:cd17365 175 -------------------------------------LLWVTFFMGLLLV---YLLNSWLPKLMVEAG-YSLSQALTITL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 297 LYEYAGIPGTLLCGWMSDKvFKGNRGATGVFFMTLVTIATVvywLNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELA 376
Cdd:cd17365 214 LLNIGGVIGSLLLGWLADR-FGPKRVLALFFALGAVSLALL---GVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFY 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489002380 377 PKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDF-FGWDGGFMVMIGGSVLAVILLVIVML 436
Cdd:cd17365 290 PTEVRATGVGWALGVGRL-GAILGPLLGGLLLAAgLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-419 |
4.58e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.40 E-value: 4.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIflpAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGwFQGMGW 138
Cdd:cd17341 30 GLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRR---VFIASLLLLLIPLLALALAVSSYWGLLVLGFLLG-FAGANF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 139 PPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND------WHAALYMPAFGAILLAIFAFAMMRDTP 212
Cdd:cd17341 106 ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFdggfvgWRNAFFVPGILLAIAAVLVLLFGDDLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 213 QscglppieeyKNDYPDDYSEKheeeltakqifMQYILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSS 292
Cdd:cd17341 186 T----------GKASALEFLKV-----------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 293 WAYFLYEYAGIPGTLLCGWMSDKVfkGNRGATGVFFmTLVTIATVVYWLNPPGNPGVDMACmiIIGFLIYGPVMLIGLHA 372
Cdd:cd17341 245 ILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLF-IVMTIGAALLSLSLPTSGTNLVLF--LALFVALGLGAGAGNGS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 489002380 373 L-ELAP---KKAAGTAAGFTGLFGYLGGSV------AASAIVGYTVDFFGWDGGFMV 419
Cdd:cd17341 320 VfRMVPfifRRELGAVTGLVGAIGGLGGFFlpllfgSSALMTGSGVGAFSLFGVLAV 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-436 |
1.05e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 30 IFIGIFFGYAAYYLVrknFALAMPYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLV 109
Cdd:cd17489 1 ILLANFFFFLSFYLL---LPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 110 MGFVPwatsSIMIMFVLLFLcgwfQGMGW---PPCGRTMVHWWSQKERGGIVSVWN-CAHNVGGGIPPLLFLLGMAWFNd 185
Cdd:cd17489 78 YLLAT----SVALLLVLRLI----HGIGWgafTTAAATLVADIIPPSRRGEGIGYYgLATTLAMALGPALGLFLYQHLG- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 186 wHAALYMPAFGAILLAIFAFAMMRDTPQScglppieeykndypddyseKHEEELTAKQIFMQYIlpNKLLWYIAIANVFV 265
Cdd:cd17489 149 -FAVLFIVAAVLALLALLLVFLVKDPPPV-------------------AAEEAEAGTRAFRRLV--EKKVLPPALILFLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 266 YLLRYGILDWSPTYLKEVKHfaldkSSWAYFLYEYAG--IPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLNP 343
Cdd:cd17489 207 SIAYGAISTFLPLYAAERGI-----SNAGLFFTVYAIalLLSRPFSGKLSDRK---GPKTVIIPGLLLLALGLLLLSFAG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 344 pgnpgvDMACMIIIGFLI---YGPVML-IGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFmv 419
Cdd:cd17489 279 ------SPWMLLLAAVLYglgFGLLFPaLQALAVDLVPPHRRGAANGTFFIFFDLGIGL-GGLLLGLVAELFGYRAMF-- 349
|
410
....*....|....*..
gi 489002380 420 mIGGSVLAVILLVIVML 436
Cdd:cd17489 350 -LLAAVVVLLALVLYIF 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-207 |
1.17e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 1 MLSIFKPA---AHKARLPAAEIDPLYRRLRWQIFIGIFFGYAAYYLVrknfALAMPYLIE--QGFSRGDLGFALSGISIA 75
Cdd:cd17473 170 LLFLPEPArksKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVI----PIQLPFLLQerGGGSAALIGLALAIASLA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 76 YGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFvpwaTSSIMIMFVLLFLCGWFQGMGWPpcgrTMVHWWSQ---- 151
Cdd:cd17473 246 GAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL----ASGLWVVLLGAILAGLGFGLLLP----TLNSWAMSlvpp 317
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 489002380 152 KERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAFAM 207
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-314 |
1.26e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 31 FIGIFFGYAAyylvRKNFALAMPYL-IEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLv 109
Cdd:cd17380 5 FLATCICYAD----RVNMPIAIVPMaKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 110 mgFVPW-ATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVG----GGIPPLLfllgMAWFN 184
Cdd:cd17380 80 --LTPLlAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGtllgGLIGPLL----LEYYG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 185 dWHAALYmpAFGAILLAIFAFammrdtpqscglppieeykndypddysekheeeltakqiFMQYILPnklLWYIAIANVF 264
Cdd:cd17380 154 -WPSVFY--FFGLLGLLWALV---------------------------------------WLIYLPP---VWAIIVAHFC 188
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489002380 265 VYLLRYGILDWSPTYLKEVkhFALDKSSWAYFLYEY-AGIPGTLLCGWMSD 314
Cdd:cd17380 189 MNWGFYILLSWLPTYFHEV--LVPLAKGWVFNVVPWlVMFPSSNVAGWLAD 237
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-171 |
2.10e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 32 IGIFFGYAAYYLVrkNFALAMPYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMG 111
Cdd:cd17321 175 LAAFLLGAALGGL--LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLA 252
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 112 FVPwATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI 171
Cdd:cd17321 253 LLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-209 |
2.70e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 30 IFIGIFFGYAAYYLVrknfalAMPYLIEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVM 107
Cdd:cd06173 215 LALALFALLGGALTV------LLPLLAKEvlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 108 LVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNcahNVGGGIPPLLFLLGMAWFNDWH 187
Cdd:cd06173 289 LVLGLSP----SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN---ALNSGAMPLGALLAGLLADALG 361
|
170 180
....*....|....*....|..
gi 489002380 188 AALYMPAFGAILLAIFAFAMMR 209
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-206 |
3.03e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 22 LYRRLRWQIFIGIFFGYAAYYLVrknFALAMPYLIEQGFSrgdLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLI 101
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFAL---YTYLAPFLTDVPGF---SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 102 LAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGwPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFllGMA 181
Cdd:cd17324 269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA-HSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALG--GLV 345
|
170 180
....*....|....*....|....*
gi 489002380 182 WFNDWHAALYMPAFGAILLAIFAFA 206
Cdd:cd17324 346 LDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-207 |
3.92e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.19 E-value: 3.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 17 AEIDPLYRRLRWQIFIGIFFGYAAYYLVRKNFALAMPYLIEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIF 95
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADlGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 96 LPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLL 175
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190
....*....|....*....|....*....|..
gi 489002380 176 FLLGMAWFnDWHAALYMPAFGAILLAIFAFAM 207
Cdd:COG0477 158 GGLLVAAL-GWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-208 |
4.57e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 4.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 22 LYRRLRWQIFIGIFFGYAAYYLvrknFALAMPYLIEQ--GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAG 99
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYG----LTTFLPTYLQTvlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 100 LILAALVMLVMGFvpWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERG-GIVSVWNCAHNVGGGIPPLLFLL 178
Cdd:cd17316 250 LILSGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAtGVGLSYNLGRLGGGGAPPLIALL 327
|
170 180 190
....*....|....*....|....*....|
gi 489002380 179 GMAWFNdwhaaLYMPAFGAILLAIFAFAMM 208
Cdd:cd17316 328 LASTGG-----TGVPALILALLAIVALIVA 352
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
59-212 |
5.98e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 45.30 E-value: 5.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 59 GFSRGDLGFAlsGISIAYG--FSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIMIMFVLLFlcgwfqgm 136
Cdd:PLN00028 67 NLTKSDIGNA--GIASVSGsiFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGF-------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 137 gwppCGRTMV---HWWSQKERGGIVSVWN-CAH---NVGGG----IPPLLFLLGMAWFND----WHAALYMPAFGAILLA 201
Cdd:PLN00028 137 ----SLATFVscqYWMSTMFNGKIVGTANgIAAgwgNLGGGvtqlLMPLVFPLIKDAGAPsftaWRIAFFVPGLLHIIMG 212
|
170
....*....|.
gi 489002380 202 IFAFAMMRDTP 212
Cdd:PLN00028 213 ILVLTLGQDLP 223
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-205 |
6.72e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 6.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 28 WQIFIGIFFGYAAYYLVrkNFALAMPYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDR-SNPRIFLPAGLILAALV 106
Cdd:cd06174 206 WLLLLAIFLVNLAYYSF--STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 107 MLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMvhwwSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNDW 186
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
170
....*....|....*....
gi 489002380 187 HAALYMPAFGAILLAIFAF 205
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
251-435 |
1.14e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 251 PNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVkHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMT 330
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRF---GRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 331 LVTIATVVYWLNPpgNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDF 410
Cdd:COG2814 84 LFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP-LLGGLLADL 160
|
170 180
....*....|....*....|....*
gi 489002380 411 FGWDGGFMVMIGGSVLAVILLVIVM 435
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
258-434 |
1.42e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 258 IAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgnrGATGVFFMTLVTIATV 337
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 338 VYWLNPPGNPGVDMACMIIIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGF 417
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAF 154
|
170
....*....|....*..
gi 489002380 418 MVMIGGSVLAVILLVIV 434
Cdd:pfam07690 155 LILAILSLLAAVLLLLP 171
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
4-205 |
2.23e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.28 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 4 IFKPAAHKARLPAAEIDPLYRRLRWQIFIGIF--FGYAAYYLVRKNFALAmpYLIEQ-GFSRGDLGFALSGISIAYGFSK 80
Cdd:cd17369 204 VFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGlrLAENVLFYLFTTFALS--YATQTlGVDRSTVLLAVLIASVVAAITI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 81 FIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSV 160
Cdd:cd17369 282 PLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASL 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 489002380 161 -WNCAHNVGGGIPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAF 205
Cdd:cd17369 362 gYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAAL 407
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
31-396 |
3.78e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 42.29 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 31 FIGIFFGYAAYYLvrknFALAMPYLIEQGF--SRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVML 108
Cdd:TIGR00886 7 WFGFFLSFLVWFA----FSPLAVFLIKDDLglSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 109 VMGFvpwATSSIMIMFVLLFLCGwFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI-----PPL----LFLLG 179
Cdd:TIGR00886 83 WAGL---AVQSYSVLLLIRLFIG-IAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVaqfvmPPIigslIFGGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 180 MAWFNDWHAALYM-PAFGAILLAIFAFAMMRDTPqscglppieeykndyPDDYSEKHEEELTAKQIFMQYILPNKLLWYI 258
Cdd:TIGR00886 159 QPAHLAWGWAFVIvPAGILLLPALLIFFVGADTP---------------PGKPATGKLSFKEALKVFGNRHTWILALLYS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 259 AIANVFVyllryGILDWSPTYLKEVkhFALDKSSWAY--FLYEYAGIPGTLLCGWMSDKVfkGNRGATGVFFMTLVTIAT 336
Cdd:TIGR00886 224 VTFGSFL-----GVSSIFAMLFKDQ--FGLSKVQAGAyaSLGGFLGSLARPAGGAISDRL--GGARKLLMNFLGVAMGAF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489002380 337 VVYWLNPPGNP-----GVDMACMIIIGF---LIYGPVMLIGlhalelapKKAAGTAAGFTGLFGYLGG 396
Cdd:TIGR00886 295 LVVLGLVSDGSlaafiVLFVALFFFAGAgngSTFALVPHIF--------RRATGAVSGLIGAIGNLGG 354
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-431 |
7.49e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 28 WQIFIGIFFGYAAYYLVRknFALAMpYLIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR-IFLPAGLILAALV 106
Cdd:cd06173 2 RLLWLAQLLSALGDWIFT--VALPW-LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrLLILADLLRALLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 107 MLVMGFVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdW 186
Cdd:cd06173 79 AVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-P 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 187 HAALYMPAFGAILLAIFAFAMMRDTPQSCGlppieeykndypddysEKHEEELTAKQIFMQYILPNKLLWYIAIANVFVY 266
Cdd:cd06173 158 GGAFAINALSFLLSALLLLFIRRPPPAAPG----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 267 LLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLNPpgN 346
Cdd:cd06173 222 LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLLGLALLVLGLSP--S 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 347 PGVDMACMIIIGFLIygPVMLIGLHAL--ELAPKKAAGTAAGFTGLFGYlGGSVAASAIVGYTVDFFGWDGGFMVMIGGS 424
Cdd:cd06173 297 LWLLLAALFLLGLAG--GLFNVPLNTLlqLRVPDELRGRVFSVYNALNS-GAMPLGALLAGLLADALGLSAVFLLAGALL 373
|
....*..
gi 489002380 425 VLAVILL 431
Cdd:cd06173 374 LLAALLL 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-433 |
1.32e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.68 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 66 GFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLvmgFVPWATS-SIMIMFVLLFLCGWFQGMGWPPCGRT 144
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL---LTPLAARgGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 145 MVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFNdWHAALYMpaFGAILLAIFAFammrdtpqscglppieeyk 224
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG-WPSIFYI--FGGLGLLWCLL------------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 225 ndypddysekheeeltakqiFMQYILPnklLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDK----SSWAYFlyey 300
Cdd:cd17318 194 --------------------WFFLVLP---VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSngflSSLPYL---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 301 AGIPGTLLCGWMSDK-VFKGNRGATGV--FFMTLVTIAtvvywlnppgnPGVdmaCMIIIGFLIYGPVMLI-------GL 370
Cdd:cd17318 247 AMWICSIVGGYLADWlRSRGILSTTTVrkLFTSIGFLG-----------PGV---FLIALGYLGSNATLAVvfltlsvGL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489002380 371 HA----------LELAPKkAAGTAAGFTGLFGYLGGSVaASAIVGYTV----DFFGWDGGFMVMIGGSVLAVILLVI 433
Cdd:cd17318 313 SGacysgflvnhLDLAPN-YAGTLMGITNTAATIAGII-SPLIVGAIVkndqTIGQWRIVFFISAAIYILGAIFYLI 387
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
74-436 |
3.98e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 74 IAYGFSKFIMGSVSDRSNPRIFLPAGLilaaLVMLVMGFVPWATSSIMIMFVLLFLcgwfQGMGWPPC---GRTMVH-WW 149
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRPVLLAGL----LLFILASLLCALASSIEQLLIARFL----QGLGAAAGsvvARAIVRdLY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 150 SQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFnDWHAALYMPAFGAILLAIFAFAMMRDTPQscglppieeykndypd 229
Cdd:cd17320 117 SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWRAIFVFLALLGLLLLLLVLLFLPETLP---------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 230 dyseKHEEELTAKQIFMQY--ILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTL 307
Cdd:cd17320 180 ----EEKRKPLLSSLLRAYkrVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 308 LCGWMSDKVFKGNRGATGVFFMTLVTIATVVYWLNPPGNPGVDMACMIIIGF---LIYGPVMLIGLHALelapKKAAGTA 384
Cdd:cd17320 256 LNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFgfgLIFPNATSLALEPF----PHVAGTA 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489002380 385 AGFTGLFGYLGGSVAASAIVgytvdfFGWDGGFMVMIGGSVLAVILLVIVML 436
Cdd:cd17320 332 SALLGFLQFLIGALAGALVG------LLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-171 |
4.31e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 32 IGIFFGYAAYYLVrknFALAMPYL-IEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVM 110
Cdd:cd17503 185 LLSFLLGLGLFGA---MFLLPLYLqNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLL 261
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489002380 111 GFVPwATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGI 171
Cdd:cd17503 262 AFLT-PDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSI 321
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
55-431 |
6.73e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 55 LIEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPwatsSIMIMFVLLFLCGWFQ 134
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD----SPWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 135 GMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLfllgMAWFNDWHAALYMPAFGAILLAIFAFAMMRDTPqs 214
Cdd:cd17477 99 AGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL----LALVGTAGALPFLIAAVLLLLALVPLLLTRRAA-- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 215 cglPPIEEykndypddysekhEEELTAKQIFMQYILpnkllwyiAIANVFVY-LLRYGILDWSPTYLKEVkHFALDKSSW 293
Cdd:cd17477 173 ---PEIEE-------------AESISLRRLLRIAPL--------ALLGAFVAgFLEGAFYSLLPLYGLRL-GLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 294 AYFLYEYAGIPGTLLCGWMSDKVfkgNRGATGVFFMTLVTIATVVYWLnPPGNPGVDMACMIIIGFLIYG--PVMLIglH 371
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRF---DRRRVLLGCALLGALAALLLPL-VPGLPLALLVLLFLWGGAAGPlyTLALA--L 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 372 ALELAPKKAAGTAAGFTGLFgYLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSVLAVILL 431
Cdd:cd17477 302 AGDRLPGDELVAANAALLLL-YGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-203 |
6.99e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.76 E-value: 6.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 31 FIGIFFGYAAYYLVRKNFALAMPYLIEQGFSR-----GDLGFALSGISIAYGFSKFIMGS-VSDRSNPR-----IFLPA- 98
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPTFFLRAFGVgdlssADVGLIFGAITCIAGVLGVLLGGiLADRLRRKtpradPLVCAv 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 99 GLILAALVMLVMgfVPWATSSIMIMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWN-CAHNVGGGIPPLLFL 177
Cdd:cd17328 289 GLLAAAPFLFLA--LVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIlLSHLLGDAGSPYLIG 366
|
170 180 190
....*....|....*....|....*....|....*..
gi 489002380 178 L-----------GMAWFNDWHAALYMPAFGAILLAIF 203
Cdd:cd17328 367 LisdllrqnkdsPLAEAASLQYALLLCSFVLVLGGFF 403
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
59-434 |
8.57e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRIFLPAGLILAALVMLVMGFVPWAtssiMIMFVLLFLCGWFQGMgw 138
Cdd:cd17393 30 GLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSV----PALALALFLFGAANGA-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 139 ppCGRTMVHWWSQKERGGIVSVWNCAHNVG--GGIPPLLFLLGMAWFN---DWHAaLYMPAFGAILLAIFAFAMMRDTPQ 213
Cdd:cd17393 104 --LDVAMNAQGVAVERAYGRPIMSSLHAMWslGGLAGALLGAAAIGAGvspGVHL-LAAAVLLLLAALVAIRALLPGTGE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 214 SCGlppieeykndypddysekHEEELTAKQIFmqyILPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSW 293
Cdd:cd17393 181 AAE------------------DRPDGAGKPGF---LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 294 AYFLYEYAGIPGTLLCGWMSDKVFKGN----RGATGVFFMTLVTIAtvvywlnppGNPGVDMACMIIIGFLIYGPVMLIg 369
Cdd:cd17393 240 GYAVFSLAMTVGRLFGDRLVDRFGDVAvlraGALLAALGLLLALLA---------PSVWVALAGFALMGLGLSVVVPLA- 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489002380 370 LHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWDGGFMVMIGGSVLAVILLVIV 434
Cdd:cd17393 310 FSAAGALPGLAAGIAVARVATLGYL-GFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
65-435 |
9.92e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 9.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRI--FLPAgLILAALVMLVMGFVPWATSSIMIMFVLLFLCGWFQGMGW---- 138
Cdd:pfam13347 35 VGLVLLVARLVDAFTDPIVGHIIDRTRTRWgrRRPW-LLLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIaytf 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 139 ---PPCGRTMVHWWSQKERGGIVSVWNCAHNVGGG----IPPLLFLLGMAWFNDWHAALYMPAFGAILLAIFAFAMMRDT 211
Cdd:pfam13347 114 feiPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLlaaaLAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGT 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 212 PqscglppieeyknDYPDDYSEKHEEELTAKQIFMQY--ILPNKLLWYIAIANVFVYL---LRYGILDWSPTYLKEvkhf 286
Cdd:pfam13347 194 K-------------ERVSMRSKEDTGQKEAGSLLDMLkeVFRNRAFLILLASFLLAALamgVLNGLLLYYFRYVLG---- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489002380 287 ALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFKgnrgATGVFFMTLVTIA-TVVYWLNPPGNPGVDMACMIIIGFlIYGPV 365
Cdd:pfam13347 257 NGFAASAFPLVFTIGALLGIPLWPPLAKRIGK----KNTYILGALITIAgFALALLLGPNNTLLFLVLYIIIGF-GYGSS 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489002380 366 MLIGLHAL--------ELAPKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIGGSVLAVILLVIVM 435
Cdd:pfam13347 332 FFLPWSMLadvvdygeLRTGKRREGTFFAMWSFISKLATGVGL-GVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVL 408
|
|
| |
