|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-316 |
2.40e-175 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 487.85 E-value: 2.40e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQgg 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGTMNFGGRTDEETSFAIMDRALDAGINFFDTADVYG----------GGRSEEIIGRWIAG-- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19087 69 RRDDIVLATKVFGPMGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAG---GLLGGVLKKMASGR--- 234
Cdd:cd19087 149 SNFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGgllTGKYGKGKRPESGRlve 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 235 RARPAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19087 229 RARYQARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPELLAEIDEL 308
|
..
gi 488994162 315 WP 316
Cdd:cd19087 309 FP 310
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-316 |
3.61e-130 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 373.74 E-value: 3.61e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDV---TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQ 77
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTMTFGGPwggVDEAEAIAILDAALDAGINFFDTADVYG----------PGRSEELLGEALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 78 qGGRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLY 157
Cdd:COG0667 71 -GRPRDDVVIATKVGRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 158 IGSSNFAGWDIATAQsvATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG---- 233
Cdd:COG0667 150 IGVSNYSAEQLRRAL--AIAEGLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSP------------LAGGlltg 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 ------------RRARPAFAR-LIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATT 300
Cdd:COG0667 216 kyrrgatfpegdRAATNFVQGyLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAAD 295
|
330
....*....|....*.
gi 488994162 301 VTLSDDTMSCLDEIWP 316
Cdd:COG0667 296 LELSAEDLAALDAALA 311
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
3-312 |
7.33e-116 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 337.25 E-value: 7.33e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 3 YTHLGRTGLKVSRLCLGTMNFGD------VTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWL 76
Cdd:cd19079 2 YVRLGNSGLKVSRLCLGCMSFGDpkwrpwVLDEEESRPIIKRALDLGINFFDTANVYS----------GGASEEILGRAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 77 QQGGRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVL 156
Cdd:cd19079 72 KEFAPRDEVVIATKVYFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 157 YIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASGRRA 236
Cdd:cd19079 152 YIGASSMYAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 237 RPAFARLIEQYRPQ-----LEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCL 311
Cdd:cd19079 232 TTDTAKLKYDYFTEadkeiVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYL 311
|
.
gi 488994162 312 D 312
Cdd:cd19079 312 E 312
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-314 |
7.72e-109 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 319.56 E-value: 7.72e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDV---------TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEI 71
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGTMTFGGGggffgawggVDQEEADRLVDIALDAGINFFDTADVYS----------EGESEEI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 72 IGRWLqqGGRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQ 151
Cdd:cd19091 71 LGKAL--KGRRDDVLIATKVRGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 152 QGKVLYIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLG---GVLK 228
Cdd:cd19091 149 QGKVRYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSgkyRRGQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 229 KMASGRRAR------PAFARliEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVT 302
Cdd:cd19091 229 PAPEGSRLRrtgfdfPPVDR--ERGYDVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLS 306
|
330
....*....|..
gi 488994162 303 LSDDTMSCLDEI 314
Cdd:cd19091 307 LTPEEIARLDKV 318
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
6-312 |
4.36e-106 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 312.23 E-value: 4.36e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGteQSPDIQQGsGLSEEIIGRWLQQGGRRERI 85
Cdd:cd19081 2 LGRTGLSVSPLCLGTMVFGWTADEETSFALLDAFVDAGGNFIDTADVYS--AWVPGNAG-GESETIIGRWLKSRGKRDRV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKVYQPMGPgpNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAG 165
Cdd:cd19081 79 VIATKVGFPMGP--NGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 166 WDIATAQSVATARHFLGLVAEQSLYNLTART-IELEVIPACRHFGLGLIPWSPLAG--GLLGGVLKKMASGRRARPAFAR 242
Cdd:cd19081 157 WRLQEALELSRQHGLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGgfLTGKYRSEADLPGSTRRGEAAK 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488994162 243 --LIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19081 237 ryLNERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-296 |
8.54e-96 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 283.26 E-value: 8.54e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQQGGRRERIVLATKVYQ 93
Cdd:cd06660 1 SRLGLGTMTFGGDGDEEEAFALLDAALEAGGNFFDTADVYGD----------GRSERLLGRWLKGRGNRDDVVIATKGGH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 94 PMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIATAQS 173
Cdd:cd06660 71 PPGGDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 174 VATARHFLGLVAEQSLYNLTART-IELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGrrarpafarlieqyrpqle 252
Cdd:cd06660 151 YAKAHGLPGFAAVQPQYSLLDRSpMEEELLDWAEENGLPLLAYSP------------LARG------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 488994162 253 ayeglcedlgetPSDVALAWLLQNPVVTAPLIGPRTVEQLQQAL 296
Cdd:cd06660 200 ------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENL 231
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
6-312 |
1.99e-95 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 285.27 E-value: 1.99e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTMNFGDV----TDEKTSASILDEALEAGINFIDTADVYgteqspdiQQGSglSEEIIGRWLQqgGR 81
Cdd:cd19080 3 LGRSGLRVSPLALGTMTFGTEwgwgADREEARAMFDAYVEAGGNFIDTANNY--------TNGT--SERLLGEFIA--GN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 82 RERIVLATKVYQPMGPG-PNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19080 71 RDRIVLATKYTMNRRPGdPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAG-----GLLGGVLKKMASGRR 235
Cdd:cd19080 151 SDTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGglltgKYQRGEEGRAGEAKG 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488994162 236 ARPAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19080 231 VTVGFGKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-306 |
4.64e-88 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 265.99 E-value: 4.64e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqGGRRERIVLA 88
Cdd:cd19074 1 GLKVSELSLGTwLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYA----------AGQAEEVLGKALK-GWPRESYVIS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDI 168
Cdd:cd19074 70 TKVFWPTGPGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 169 ATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG------RRARPAFAR 242
Cdd:cd19074 150 AEAHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSP------------LAQGlltgkyRDGIPPPSR 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 243 L------------IEQYRPQLEAYEGL---CEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDD 306
Cdd:cd19074 218 SratdednrdkkrRLLTDENLEKVKKLkpiADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-312 |
3.92e-85 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 258.61 E-value: 3.92e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFG----DVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLqqGGRRERI 85
Cdd:cd19084 1 DLKVSRIGLGTWAIGgtwwGEVDDQESIEAIKAAIDLGINFFDTAPVYG----------FGHSEEILGKAL--KGRRDDV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKVYQPMGPGPNDRR-LSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19084 69 VIATKCGLRWDGGKGVTKdLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 GWDIATAQSVATarhflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG----------- 233
Cdd:cd19084 149 VEQLEEARKYGP------IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGP------------LAQGlltgkykkept 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 ------RRARPAFARliEQYRPQLEAYEGL---CEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLS 304
Cdd:cd19084 211 fppddrRSRFPFFRG--ENFEKNLEIVDKLkeiAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELT 288
|
....*...
gi 488994162 305 DDTMSCLD 312
Cdd:cd19084 289 EEELKEID 296
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
13-314 |
3.22e-81 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 249.40 E-value: 3.22e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 13 VSRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGTEQSPDIQqgsGLSEEIIGRWLQQGGRRERIVLATKVy 92
Cdd:cd19094 1 VSEICLGTMTWGEQNTEAEAHEQLDYAFDEGVNFIDTAEMYPVPPSPETQ---GRTEEIIGSWLKKKGNRDKVVLATKV- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 93 qpMGPG-------PNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPW------------------EEIWQAME 147
Cdd:cd19094 77 --AGPGegitwprGGGTRLDRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTPLfgggyytepseeedsvsfEEQLEALG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 148 LLVQQGKVLYIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvl 227
Cdd:cd19094 155 ELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSP---------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 228 kkMASG--------RRARPAFARL------IEQYR-----PQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRT 288
Cdd:cd19094 225 --LAGGvltgkyldGAARPEGGRLnlfpgyMARYRspqalEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATT 302
|
330 340
....*....|....*....|....*.
gi 488994162 289 VEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19094 303 LEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
13-314 |
7.50e-80 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 244.80 E-value: 7.50e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 13 VSRLCLGTMNFGD-----VTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqgGRRERIVL 87
Cdd:cd19085 1 VSRLGLGCWQFGGgywwgDQDDEESIATIHAALDAGINFFDTAEAYG----------DGHSEEVLGKALK--GRRDDVVI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 88 ATKVYqPMGPGPNDrrlsayhIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWD 167
Cdd:cd19085 69 ATKVS-PDNLTPED-------VRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 168 IATAQSVATarhflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG-------------- 233
Cdd:cd19085 141 LEEALDAGR------IDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSP------------LAQGlltgkfssaedfpp 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 -----RRARPAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTM 308
Cdd:cd19085 203 gdartRLFRHFEPGAEEETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVL 282
|
....*.
gi 488994162 309 SCLDEI 314
Cdd:cd19085 283 ERLDEI 288
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-315 |
7.62e-78 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 239.52 E-value: 7.62e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 16 LCLGTMNFGD---VTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQ-QGGRRERIVLATKV 91
Cdd:pfam00248 1 IGLGTWQLGGgwgPISKEEALEALRAALEAGINFIDTAEVYGD----------GKSEELLGEALKdYPVKRDKVVIATKV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 92 yqPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFagwDIATA 171
Cdd:pfam00248 71 --PDGDGPWPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNF---DAEQI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 172 QSVATARhFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASGRR--ARPAFARLIEQYRP 249
Cdd:pfam00248 146 EKALTKG-KIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPgeRRRLLKKGTPLNLE 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488994162 250 QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEIW 315
Cdd:pfam00248 225 ALEALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
6-308 |
1.29e-70 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 221.71 E-value: 1.29e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTM---NFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqgGRR 82
Cdd:cd19076 5 LGTQGLEVSALGLGCMgmsAFYGPADEEESIATLHRALELGVTFLDTADMYG----------PGTNEELLGKALK--DRR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 83 ERIVLATKVYQPMGPGPNDRRL--SAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19076 73 DEVVIATKFGIVRDPGSGFRGVdgRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFAGWDIATAQSVATarhflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPL-----AGGLLGGVLKKMASGRR 235
Cdd:cd19076 153 SEASADTIRRAHAVHP------ITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLgrgflTGAIKSPEDLPEDDFRR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 236 ARPafarlieqyRPQLEAYEG----------LCEDLGETPSDVALAWLLQ--NPVVtaPLIGPRTVEQLQQALHATTVTL 303
Cdd:cd19076 227 NNP---------RFQGENFDKnlklvekleaIAAEKGCTPAQLALAWVLAqgDDIV--PIPGTKRIKYLEENVGALDVVL 295
|
....*
gi 488994162 304 SDDTM 308
Cdd:cd19076 296 TPEEL 300
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-314 |
7.68e-70 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 220.16 E-value: 7.68e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQG 79
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSwVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYA----------NGQSEEIMGQAIKEL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 G-RRERIVLATKVYQPM-GPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLY 157
Cdd:cd19143 71 GwPRSDYVVSTKIFWGGgGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 158 IGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTART-IELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG--- 233
Cdd:cd19143 151 WGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSP------------LASGllt 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 -----------RRARPAFARLIEQYRP----QLEAYEGL---CEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQA 295
Cdd:cd19143 219 gkynngipegsRLALPGYEWLKDRKEElgqeKIEKVRKLkpiAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEEN 298
|
330 340
....*....|....*....|.
gi 488994162 296 LHATTV--TLSDDTMSCLDEI 314
Cdd:cd19143 299 LKALEVlpKLTPEVMEKIEAI 319
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-300 |
8.70e-68 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 214.12 E-value: 8.70e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYG--TEQSPDiqqgsGLSEEIIGRWLQQGGRRERIVLATKV 91
Cdd:cd19752 1 SELCLGTMYFGTRTDEETSFAILDRYVAAGGNFLDTANNYAfwTEGGVG-----GESERLIGRWLKDRGNRDDVVIATKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 92 ---YQPMGPGPNDRR-LSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWD 167
Cdd:cd19752 76 gagPRDPDGGPESPEgLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 168 IATAQSVATARHFLGLVAEQSLYNL----------TARTIELEVIPACR-HFGLGLIPWSPlaggllggvlkkMASGRRA 236
Cdd:cd19752 156 LERARQIARQQGWAEFSAIQQRHSYlrprpgadfgVQRIVTDELLDYASsRPDLTLLAYSP------------LLSGAYT 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 237 RPAfARLIEQYRPQ-----LEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATT 300
Cdd:cd19752 224 RPD-RPLPEQYDGPdsdarLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
11-298 |
5.72e-65 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 205.02 E-value: 5.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 11 LKVSRLCLGTMNFG----DVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqgGRRERIV 86
Cdd:cd19086 1 LEVSEIGFGTWGLGgdwwGDVDDAEAIRALRAALDLGINFFDTADVYG----------DGHSERLLGKALK--GRRDKVV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKV-YQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHI-DRHTPWEEIWQAMELLVQQGKVLYIGSSnfa 164
Cdd:cd19086 69 IATKFgNRFDGGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPpDEVLDNDELFEALEKLKQEGKIRAYGVS--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 gwdIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIpwsplaggllggvlkkmasgrrARPAFArli 244
Cdd:cd19086 146 ---VGDPEEALAALRRGGIDVVQVIYNLLDQRPEEELFPLAEEHGVGVI----------------------ARVPLA--- 197
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 488994162 245 eqyrpqleayEGLcedLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:cd19086 198 ----------SGL---LTGKLAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
14-299 |
2.42e-64 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 205.09 E-value: 2.42e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdIQQGSGLSEEIIGRWLQQGGRRERIVLATKVYQ 93
Cdd:cd19082 1 SRIVLGTADFGTRIDEEEAFALLDAFVELGGNFIDTARVYG------DWVERGASERVIGEWLKSRGNRDKVVIATKGGH 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 94 PMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNfagWD---IAT 170
Cdd:cd19082 75 PDLEDMSRSRLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN---WSterIAE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 171 AQSVATARHFLGLVAEQSLYNLtARTIElEVIPAC---------RHF----GLGLIPWSPlaggllggvlkkMASG---R 234
Cdd:cd19082 152 ANAYAKAHGLPGFAASSPQWSL-ARPNE-PPWPGPtlvamdeemRAWheenQLPVFAYSS------------QARGffsK 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488994162 235 RARPAFARLIEQYRP--------QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHAT 299
Cdd:cd19082 218 RAAGGAEDDSELRRVyyseenfeRLERAKELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAA 290
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-312 |
2.23e-61 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 197.45 E-value: 2.23e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 12 KVSRLCLGTMNFGDVT-------DEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQQGGRRER 84
Cdd:cd19093 1 EVSPLGLGTWQWGDRLwwgygeyGDEDLQAAFDAALEAGVNLFDTAEVYGT----------GRSERLLGRFLKELGDRDE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 85 IVLATKVYqpmgPGPndRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHidrHTPW----EEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19093 71 VVIATKFA----PLP--WRLTRRSVVKALKASLERLGLDSIDLYQLHW---PGPWysqiEALMDGLADAVEEGLVRAVGV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFAGWDIATAQSvATARHFLGLVAEQSLYNLTARTIE-LEVIPACRHFGLGLIPWSPLAGGLLG--GVLKKMASGRRAR 237
Cdd:cd19093 142 SNYSADQLRRAHK-ALKERGVPLASNQVEYSLLYRDPEqNGLLPACDELGITLIAYSPLAQGLLTgkYSPENPPPGGRRR 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 238 PAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVtaPLIGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19093 221 LFGRKNLEKVQPLLDALEEIAEKYGKTPAQVALNWLIAKGVV--PIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
10-316 |
6.81e-61 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 197.26 E-value: 6.81e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGD-------VTDEKTSASILDEALEAGINFIDTADVYgteqspdiqQGsGLSEEIIGRWLQQGGRR 82
Cdd:cd19146 8 GVRVSPLCLGAMSFGEawksmmgECDKETAFKLLDAFYEQGGNFIDTANNY---------QG-EESERWVGEWMASRGNR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 83 ERIVLATK---VYQPMGPGP---NDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVL 156
Cdd:cd19146 78 DEMVLATKyttGYRRGGPIKiksNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 157 YIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAG---GLLGGVLKKMASG 233
Cdd:cd19146 158 YLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQgqfRTEEEFKRRGRSG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 RRARPAfarlIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDE 313
Cdd:cd19146 238 RKGGPQ----TEKERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIED 313
|
...
gi 488994162 314 IWP 316
Cdd:cd19146 314 AYP 316
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-313 |
7.13e-59 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 191.29 E-value: 7.13e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTM----NFGDVTDEKTSASILDEALEAGINFIDTADVYGTEqspdiqqgsgLSEEIIGRWLQqgGRRERI 85
Cdd:cd19078 1 GLEVSAIGLGCMgmshGYGPPPDKEEMIELIRKAVELGITFFDTAEVYGPY----------TNEELVGEALK--PFRDQV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATK---VYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSN 162
Cdd:cd19078 69 VIATKfgfKIDGGKPGPLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 163 fagwdiATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG--------- 233
Cdd:cd19078 149 ------AGVETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSP------------LGKGfltgkiden 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 --------RRARPAFA-RLIEQYRPQLEAYEGLCEDLGETPSDVALAWLL-QNPVVtAPLIGPRTVEQLQQALHATTVTL 303
Cdd:cd19078 211 tkfdegddRASLPRFTpEALEANQALVDLLKEFAEEKGATPAQIALAWLLaKKPWI-VPIPGTTKLSRLEENIGAADIEL 289
|
330
....*....|
gi 488994162 304 SDDTMSCLDE 313
Cdd:cd19078 290 TPEELREIED 299
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
13-304 |
3.44e-58 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 188.20 E-value: 3.44e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 13 VSRLCLGTMNF------GDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLqqGGRRERIV 86
Cdd:cd19088 1 VSRLGYGAMRLtgpgiwGPPADREEAIAVLRRALELGVNFIDTADSYGP----------DVNERLIAEAL--HPYPDDVV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKV-YQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNfag 165
Cdd:cd19088 69 IATKGgLVRTGPGWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSN--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 166 wdiATAQSVATARHFLGLVAEQSLYNLTARTIElEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRARPafarlie 245
Cdd:cd19088 146 ---VTVAQIEEARAIVRIVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFP------------LGGGDLAQP------- 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 246 qyrpqLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLS 304
Cdd:cd19088 203 -----GGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
6-313 |
2.96e-57 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 187.48 E-value: 2.96e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGT------MNFGDvTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQqg 79
Cdd:cd19149 4 LGKSGIEASVIGLGTwaigggPWWGG-SDDNESIRTIHAALDLGINLIDTAPAYGF----------GHSEEIVGKAIK-- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 GRRERIVLATK------------VYQPMGPGPNdRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAME 147
Cdd:cd19149 71 GRRDKVVLATKcglrwdreggsfFFVRDGVTVY-KNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 148 LLVQQGKVLYIGSSNFAGWDIATAQSVATarhflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLGGVL 227
Cdd:cd19149 150 ELKRQGKIRAIGASNVSVEQIKEYVKAGQ------LDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 228 KK-----MASGRRARPAF--------ARLIEQYRPqleayegLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQ 294
Cdd:cd19149 224 TPdrefdAGDARSGIPWFspenrekvLALLEKWKP-------LCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEE 296
|
330
....*....|....*....
gi 488994162 295 ALHATTVTLSDDTMSCLDE 313
Cdd:cd19149 297 NAKAGDIRLSAEDIATMRS 315
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-314 |
7.15e-57 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 186.34 E-value: 7.15e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 28 DEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQqgGRRERIVLATKV-YQPMGPGPNDRRLSA 106
Cdd:cd19102 24 DDRDSIAAIRAALDLGINWIDTAAVYGL----------GHSEEVVGRALK--GLRDRPIVATKCgLLWDEEGRIRRSLKP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 107 YHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIATAQSVAtarhflGLVAE 186
Cdd:cd19102 92 ASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIH------PIASL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 187 QSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG--------------------RRAR----PAFAR 242
Cdd:cd19102 166 QPPYSLLRRGIEAEILPFCAEHGIGVIVYSP------------MQSGlltgkmtpervaslpaddwrRRSPffqePNLAR 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 243 ---LIEQYRPqleayegLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19102 234 nlaLVDALRP-------IAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-312 |
2.18e-56 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 183.58 E-value: 2.18e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFG-----DVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqGGRRER 84
Cdd:cd19072 1 GEEVPVLGLGTWGIGggmskDYSDDKKAIEALRYAIELGINLIDTAEMYG----------GGHAEELVGKAIK-GFDRED 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 85 IVLATKVYqPMGPGPNDrrlsayhIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19072 70 LFITTKVS-PDHLKYDD-------VIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 GWDIATAQSvATARHflGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRARPAFARLI 244
Cdd:cd19072 142 LEELEEAQS-YLKKG--PIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSP------------LEKGKLSNAKGSPLL 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488994162 245 EQyrpqleayegLCEDLGETPSDVALAWLLQNPVVTaPLIGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19072 207 DE----------IAKKYGKTPAQIALNWLISKPNVI-AIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-314 |
6.97e-55 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 181.89 E-value: 6.97e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTM-NFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQG 79
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWsTFSTAISEEQAEEIVTLAYENGINYFDTSDAFT----------SGQAETELGRILKKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 G-RRERIVLATKVYqpMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYI 158
Cdd:cd19142 71 GwKRSSYIVSTKIY--WSYGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYW 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 159 GSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTAR-TIELEVIPACRHFGLGLIPWSP---------LAGGLLGGVLK 228
Cdd:cd19142 149 GTSRWSPVEIMEAFSIARQFNCPTPICEQSEYHMFCReKMELYMPELYNKVGVGLITWSPlslgldpgiSEETRRLVTKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 229 KMASGRRARPAFARL----IEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTV--T 302
Cdd:cd19142 229 SFKSSKYKVGSDGNGiheeTRRASHKLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQLlpK 308
|
330
....*....|..
gi 488994162 303 LSDDTMSCLDEI 314
Cdd:cd19142 309 LNSAVMEELERI 320
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-306 |
4.31e-53 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 176.68 E-value: 4.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 3 YTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGTEQspdiqqgsGLSEEIIGRWLQQ--G 79
Cdd:cd19089 1 YRRCGRSGLHLPAISLGLwHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGPPP--------GSAEENFGRILKRdlR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 GRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIG 159
Cdd:cd19089 73 PYRDELVISTKAGYGMWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 SSNFAGWDIATAQSVATARHfLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG------ 233
Cdd:cd19089 153 ISNYPGAKARRAIALLRELG-VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSP------------LAQGlltdky 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 --------RRARPAFARLIEQYRP----QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA-TT 300
Cdd:cd19089 220 lngippdsRRAAESKFLTEEALTPekleQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAAlKN 299
|
....*.
gi 488994162 301 VTLSDD 306
Cdd:cd19089 300 LDFSEE 305
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-314 |
3.21e-52 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 174.03 E-value: 3.21e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGDV----TDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQQGGRRERI 85
Cdd:cd19148 1 DLPVSRIALGTWAIGGWmwggTDEKEAIETIHKALDLGINLIDTAPVYGF----------GLSEEIVGKALKEYGKRDRV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKV-YQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19148 71 VIATKVgLEWDEGGEVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 GWDIATAQSVATarhflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggVLKKMASG----------- 233
Cdd:cd19148 151 PEQMETFRKVAP------LHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGA--------LCRGLLSGkmtkdtkfegd 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 --RRARPAFARliEQYRPQLEAYEGL----CEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDT 307
Cdd:cd19148 217 dlRRTDPKFQE--PRFSQYLAAVEELdklaQERYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLNDED 294
|
....*..
gi 488994162 308 MSCLDEI 314
Cdd:cd19148 295 MKEIDAI 301
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-293 |
1.10e-51 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 171.23 E-value: 1.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDVtdektSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqGG 80
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLPRE-----SPELLRRALDLGINYFDTAEGYG----------NGNSEEIIGEALK-GL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKVYQPMGPGPNDrrlsayHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPW---EEIWQAMELLVQQGKVLY 157
Cdd:cd19105 65 RRDKVFLATKASPRLDKKDKA------ELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 158 IG-SSNFAGWDIATAqsVATARHF-LGLVAeqslYNLTARTIELE-VIPACRHFGLGLIpwsplaggllggVLKKMASGR 234
Cdd:cd19105 139 IGfSTHDNMAEVLQA--AIESGWFdVIMVA----YNFLNQPAELEeALAAAAEKGIGVV------------AMKTLAGGY 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 235 RARpafarlIEQYRPQLEayeglcedlGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQ 293
Cdd:cd19105 201 LQP------ALLSVLKAK---------GFSLPQAALKWVLSNPRVDTVVPGMRNFAELE 244
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-318 |
1.31e-51 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 173.89 E-value: 1.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGTEQSPDIQqgsGLSEEIIGRWLQQGG 80
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQ---GLTETYIGNWLAKRG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKVYQPM-----GPGPN---DRRlsayHIRKACEDSLRRLKTDHIDVYQMHHIDRHT--------PWEEIWQ 144
Cdd:PRK10625 78 SREKLIIASKVSGPSrnndkGIRPNqalDRK----NIREALHDSLKRLQTDYLDLYQVHWPQRPTncfgklgySWTDSAP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 145 AMELL---------VQQGKVLYIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPW 215
Cdd:PRK10625 154 AVSLLetldalaeqQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 216 SPLAGGLLGGvlkKMASGrrARPA------FARLI----EQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIG 285
Cdd:PRK10625 234 SCLAFGTLTG---KYLNG--AKPAgarntlFSRFTrysgEQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFVASTLLG 308
|
330 340 350
....*....|....*....|....*....|....*...
gi 488994162 286 PRTVEQLQQALHATTVTLSDDTMSCLDEI-----WPGP 318
Cdd:PRK10625 309 ATTMEQLKTNIESLHLTLSEEVLAEIEAVhqvytYPAP 346
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
1-304 |
4.20e-51 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 171.10 E-value: 4.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDV-TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQ- 78
Cdd:COG4989 1 MKRIKLGASGLSVSRIVLGCMRLGEWdLSPAEAAALIEAALELGITTFDHADIYG----------GYTCEALFGEALKLs 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 79 GGRRERIVLATKV-YQPMGPGPNDR----RLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQG 153
Cdd:COG4989 71 PSLREKIELQTKCgIRLPSEARDNRvkhyDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 154 KVLYIGSSNFAGWDIATAQSVATARhflgLVAEQ---SLYNLTArtIELEVIPACRHFGLGLIPWSPlaggllggvlkkM 230
Cdd:COG4989 151 KVRHFGVSNFTPSQFELLQSALDQP----LVTNQielSLLHTDA--FDDGTLDYCQLNGITPMAWSP------------L 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488994162 231 ASGR---RARPAFARLieqyRPQLEAyegLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLS 304
Cdd:COG4989 213 AGGRlfgGFDEQFPRL----RAALDE---LAEKYGVSPEAIALAWLLRHPAGIQPVIGTTNPERIKAAAAALDIELT 282
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
6-309 |
1.84e-49 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 167.22 E-value: 1.84e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTMNF----GDVTDEKTSASILDEALEAGINFIDTADVYGTEQSpdiqqgsglsEEIIGRWLQqGGR 81
Cdd:cd19145 5 LGSQGLEVSAQGLGCMGLsgdyGAPKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTN----------EVLLGKALK-DGP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 82 RERIVLATK--VYQPMGPGPNDRRLSAYhIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIG 159
Cdd:cd19145 74 REKVQLATKfgIHEIGGSGVEVRGDPAY-VRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 SSNfagwdiATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASG-----R 234
Cdd:cd19145 153 LSE------ASADTIRRAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLensdvR 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488994162 235 RARPAF-ARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQ--NPVVtaPLIGPRTVEQLQQALHATTVTLSDDTMS 309
Cdd:cd19145 227 KSHPRFqGENLEKNKVLYERVEALAKKKGCTPAQLALAWVLHqgEDVV--PIPGTTKIKNLNQNIGALSVKLTKEDLK 302
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
9-304 |
4.54e-49 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 165.42 E-value: 4.54e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNFGDVTDEKTSA-SILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWL-QQGGRRERIV 86
Cdd:cd19092 2 EGLEVSRLVLGCMRLADWGESAEELlSLIEAALELGITTFDHADIYGG----------GKCEELFGEALaLNPGLREKIE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATK--VYQPMGPGPNDRR---LSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSS 161
Cdd:cd19092 72 IQTKcgIRLGDDPRPGRIKhydTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 162 NFAGWDIATAQSVATARhflgLVAEQ---SLYNLTArtIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRARP 238
Cdd:cd19092 152 NFTPSQIELLQSYLDQP----LVTNQielSLLHTEA--IDDGTLDYCQLLDITPMAWSP------------LGGGRLFGG 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488994162 239 AfarlIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLS 304
Cdd:cd19092 214 F----DERFQRLRAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELT 275
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
6-314 |
1.22e-48 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 164.90 E-value: 1.22e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGT-----MNFGDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQqGG 80
Cdd:cd19083 4 LGKSDIDVNPIGLGTnavggHNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGL----------GRSEELVGEVLK-EY 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19083 73 NRNEVVIATKGAHKFGGDGSVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFagwdiaTAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG------- 233
Cdd:cd19083 153 SNF------SLEQLKEANKDGYVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFP------------LASGllagkyt 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 ----------RRARPAFARliEQYRPQLEAYEGL---CEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATT 300
Cdd:cd19083 215 kdtkfpdndlRNDKPLFKG--ERFSENLDKVDKLksiADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALD 292
|
330
....*....|....
gi 488994162 301 VTLSDDTMSCLDEI 314
Cdd:cd19083 293 VTLTEEEIAFIDAL 306
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
10-312 |
1.46e-48 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 165.38 E-value: 1.46e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGDV-------TDEKTSASILDEALEAGINFIDTADVYGTEQSpdiqqgsglsEEIIGRWLQQGGRR 82
Cdd:cd19147 7 GIRVSPLILGAMSIGDAwsgfmgsMDKEQAFELLDAFYEAGGNFIDTANNYQDEQS----------ETWIGEWMKSRKNR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 83 ERIVLATKV---YQPMGPG-PNDRRLSAYHIRK---ACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKV 155
Cdd:cd19147 77 DQIVIATKFttdYKAYEVGkGKAVNYCGNHKRSlhvSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 156 LYIGSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSplAGGLLGGVLKKMASGRR 235
Cdd:cd19147 157 LYLGVSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWD--VLGGGKFQSKKAVEERK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 236 AR----PAFARLIEQYRPQL---EAYEGLCEDLG-ETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDT 307
Cdd:cd19147 235 KNgeglRSFVGGTEQTPEEVkisEALEKVAEEHGtESVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEE 314
|
....*
gi 488994162 308 MSCLD 312
Cdd:cd19147 315 IEYLE 319
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-297 |
2.87e-48 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 161.88 E-value: 2.87e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTMNFGDVTDEKTSAsILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGRWLQqgGRRERI 85
Cdd:cd19100 4 LGRTGLKVSRLGFGGGPLGRLSQEEAAA-IIRRALDLGINYFDTAPSYGD------------SEEKIGKALK--GRRDKV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKVYQPMGPGpndrrlsayhIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEI------WQAMELLVQQGKVLYIG 159
Cdd:cd19100 69 FLATKTGARDYEG----------AKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVfgpggaLEALLEAKEEGKIRFIG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 ssnfagwdiATAQSVATARHFLG-------LVAeqslYNLTARTI---ELEVIPACRHFGLGLIpwsplaggllggVLKK 229
Cdd:cd19100 139 ---------ISGHSPEVLLRALEtgefdvvLFP----INPAGDHIdsfREELLPLAREKGVGVI------------AMKV 193
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488994162 230 MASGRrarpafarlieqyrpqleayegLCEDLGETPSDvALAWLLQNPVVTAPLIGPRTVEQLQQALH 297
Cdd:cd19100 194 LAGGR----------------------LLSGDPLDPEQ-ALRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-298 |
1.31e-47 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 163.84 E-value: 1.31e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFgDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGRWLQqgG 80
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGMRL-PRKDEEEAEALIRRAIDNGINYIDTARGYGD------------SEEFLGKALK--G 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKvyqpMGPGPNDRRlsayHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWE------EIWQAMELLVQQGK 154
Cdd:COG1453 66 PRDKVILATK----LPPWVRDPE----DMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEkvlkpgGALEALEKAKAEGK 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 155 VLYIGSSNFAGWDIataqsvatarhFLGLVAE--------QslYNL--TARTIELEVIPACRHFGLGLIPWSPlaggllg 224
Cdd:COG1453 138 IRHIGFSTHGSLEV-----------IKEAIDTgdfdfvqlQ--YNYldQDNQAGEEALEAAAEKGIGVIIMKP------- 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488994162 225 gvlkkMASGRRARPafarlieqyrPQlEAYEGLCEDLgeTPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:COG1453 198 -----LKGGRLANP----------PE-KLVELLCPPL--SPAEWALRFLLSHPEVTTVLSGMSTPEQLDENLKT 253
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
4-314 |
4.03e-46 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 158.76 E-value: 4.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 4 THLGRTGLKVSRLCLGTMNF----GDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGRW-LQQ 78
Cdd:cd19144 4 RTLGRNGPSVPALGFGAMGLsafyGPPKPDEERFAVLDAAFELGCTFWDTADIYGD------------SEELIGRWfKQN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 79 GGRRERIVLATKV--YQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVL 156
Cdd:cd19144 72 PGKREKIFLATKFgiEKNVETGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 157 YIGSSNFAGWDIATAQSVataRHFLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggVLKKMASG--- 233
Cdd:cd19144 152 HIGLSECSAETLRRAHAV---HPIAAVQIEYSPFSLDIERPEIGVLDTCRELGVAIVAYSP--------LGRGFLTGair 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 ----------RRARPAFARliEQYRPQLE---AYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATT 300
Cdd:cd19144 221 spddfeegdfRRMAPRFQA--ENFPKNLElvdKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALK 298
|
330
....*....|....
gi 488994162 301 VTLSDDTMSCLDEI 314
Cdd:cd19144 299 VKLTEEEEKEIREI 312
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
9-312 |
1.59e-45 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 155.87 E-value: 1.59e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNFG-DVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqgGRRERIVL 87
Cdd:cd19138 7 DGTKVPALGQGTWYMGeDPAKRAQEIEALRAGIDLGMTLIDTAEMYG----------DGGSEELVGEAIR--GRRDKVFL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 88 ATKVYqPMGPGPNDrrlsayhIRKACEDSLRRLKTDHIDVYQMHHIDRHtPWEEIWQAMELLVQQGKVLYIGSSNFAGWD 167
Cdd:cd19138 75 VSKVL-PSNASRQG-------TVRACERSLRRLGTDYLDLYLLHWRGGV-PLAETVAAMEELKKEGKIRAWGVSNFDTDD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 168 IATAQSVATARHflgLVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLggvlkkMASGRRARPAFARLIEQY 247
Cdd:cd19138 146 MEELWAVPGGGN---CAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGL------LRRGLLENPTLKEIAARH 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488994162 248 rpqleayeglcedlGETPSDVALAWLLQNPVVTAplIgPRT--VEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19138 217 --------------GATPAQVALAWVLRDGNVIA--I-PKSgsPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
15-315 |
1.45e-43 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 151.55 E-value: 1.45e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 15 RLCLGTMNFGDV---TDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGrwlQQGGRRERIVLATKV 91
Cdd:cd19075 2 KIILGTMTFGSQgrfTTAEAAAELLDAFLERGHTEIDTARVYPD----------GTSEELLG---ELGLGERGFKIDTKA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 92 yqPMGPGPNdrrLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIATA 171
Cdd:cd19075 69 --NPGVGGG---LSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 172 QSVATARhflGLVAE---QSLYNLTARTIELEVIPACRHFGLGLIPWSPLAG---GLLGGVLKKMASGRRARPAfARLIE 245
Cdd:cd19075 144 VEICKEN---GWVLPtvyQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGgflTGKYKYSEDKAGGGRFDPN-NALGK 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 246 QYRPQ---------LEAYEGLCEDLGETPSDVALAWLLQNPVVTAP-----LIGPRTVEQLQQALHATTV-TLSDDTMSC 310
Cdd:cd19075 220 LYRDRywkpsyfeaLEKVEEAAEKEGISLAEAALRWLYHHSALDGEkgdgvILGASSLEQLEENLAALEKgPLPEEVVKA 299
|
....*
gi 488994162 311 LDEIW 315
Cdd:cd19075 300 IDEAW 304
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-298 |
1.88e-41 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 144.68 E-value: 1.88e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDVT---DEKTSASILDEALEAGINFIDTADVYGteqspdiqqgsgLSEEIIGRWLQqGGRRERIVLATK 90
Cdd:cd19095 1 SVLGLGTSGIGRVWgvpSEAEAARLLNTALDLGINLIDTAPAYG------------RSEERLGRALA-GLRRDDLFIATK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 91 VYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGwDIAT 170
Cdd:cd19095 68 VGTHGEGGRDRKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGE-ELEA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 171 aqsvATARHFLGLVaeQSLYNLTARTIElEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRARPAFARLIeqYRPQ 250
Cdd:cd19095 147 ----AIASGVFDVV--QLPYNVLDREEE-ELLPLAAEAGLGVIVNRP------------LANGRLRRRVRRRPL--YADY 205
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 488994162 251 LEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:cd19095 206 ARRPEFAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
2-301 |
4.38e-41 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 145.28 E-value: 4.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 2 NYTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQGG 80
Cdd:cd19141 1 PYRNLGKSGLRVSCLGLGTwVTFGSQISDEVAEELVTLAYENGINLFDTAEVYA----------AGKAEIVLGKILKKKG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 -RRERIVLATKVYQPmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIG 159
Cdd:cd19141 71 wRRSSYVITTKIFWG-GKAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 SSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEVIPACRH-FGLGLIPWSPLAGGllggvlkkMASGR--RA 236
Cdd:cd19141 150 TSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPELFHkIGVGAMTWSPLACG--------ILSGKydDG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 237 RPAFAR-------------LIEQYRPQ---LEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATT 300
Cdd:cd19141 222 VPEYSRaslkgyqwlkekiLSEEGRRQqakLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQ 301
|
.
gi 488994162 301 V 301
Cdd:cd19141 302 V 302
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-314 |
1.58e-40 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 144.36 E-value: 1.58e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQG 79
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTwVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYA----------AGKAERTLGNILKSK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 G-RRERIVLATKVYQPmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYI 158
Cdd:cd19160 73 GwRRSSYVVTTKIYWG-GQAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 159 GSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTAR-TIELEvIPACRH-FGLGLIPWSPlaggllggvlkkMASGRRA 236
Cdd:cd19160 152 GTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQReKVEMQ-LPELYHkIGVGSVTWSP------------LACGLIT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 237 RPAFARLIEQYRPQLEAYEGLCED----------------------LGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQ 294
Cdd:cd19160 219 GKYDGRVPDTCRAAVKGYQWLKEKvqseegkkqqakvkelhpiadrLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIE 298
|
330 340
....*....|....*....|..
gi 488994162 295 ALHATTV--TLSDDTMSCLDEI 314
Cdd:cd19160 299 NLGSIQVlsQLTPQTVMEIDAL 320
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-314 |
2.26e-40 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 144.03 E-value: 2.26e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQG 79
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTwVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYA----------AGKAEVILGSIIKKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 G-RRERIVLATKVYQPmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYI 158
Cdd:cd19159 71 GwRRSSLVITTKLYWG-GKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYW 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 159 GSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTAR-TIELEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMA--SGRR 235
Cdd:cd19159 150 GTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQReKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVpeSSRA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 236 ARPAFARLIE--------QYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTV--TLSD 305
Cdd:cd19159 230 SLKCYQWLKErivseegrKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVlpKMTS 309
|
....*....
gi 488994162 306 DTMSCLDEI 314
Cdd:cd19159 310 HVVNEIDNI 318
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-306 |
8.29e-40 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 141.15 E-value: 8.29e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDV---TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgsgLSEEIIGRWLQQGGRrERIVLATK 90
Cdd:cd19090 1 SALGLGTAGLGGVfggVDDDEAVATIRAALDLGINYIDTAPAYG------------DSEERLGLALAELPR-EPLVLSTK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 91 VyqpmGPGPNDR-RLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEE-----IWQAMELLVQQGKVLYIGssnFA 164
Cdd:cd19090 68 V----GRLPEDTaDYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDIlapggALEALLELKEEGLIKHIG---LG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 GWDIAT-AQSVATARHFLGLVAEQslYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASGRRaRPAFARL 243
Cdd:cd19090 141 GGPPDLlRRAIETGDFDVVLTANR--YTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPPERVRYTY-RWLSPEL 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488994162 244 IEQYRpQLEAyegLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDD 306
Cdd:cd19090 218 LDRAK-RLYE---LCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-315 |
6.41e-38 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 137.40 E-value: 6.41e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 2 NYTHLGRTGLKVSRLCLGTMNFGDV---TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQq 78
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGGGGIGGLmgrTTREEQIAAVRRALDLGINFFDTAPSYG----------DGKSEENLGRALK- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 79 gGRRERIVLATKVyqpmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHH-IDRHTPWE--------------EIW 143
Cdd:cd19104 70 -GLPAGPYITTKV----RLDPDDLGDIGGQIERSVEKSLKRLKRDSVDLLQLHNrIGDERDKPvggtlsttdvlglgGVA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 144 QAMELLVQQGKVLYIGssnFAGWDI--ATAQSVATARhflgLVAEQSLYNL------TARTIEL------EVIPACRHFG 209
Cdd:cd19104 145 DAFERLRSEGKIRFIG---ITGLGNppAIRELLDSGK----FDAVQVYYNLlnpsaaEARPRGWsaqdygGIIDAAAEHG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 210 LGLIPWSPlaggllggvlkkMASG------RRARPA----FARLIEQYRpQLEAYEGLCEDLGETPSDVALAWLLQNPVV 279
Cdd:cd19104 218 VGVMGIRV------------LAAGalttslDRGREApptsDSDVAIDFR-RAAAFRALAREWGETLAQLAHRFALSNPGV 284
|
330 340 350
....*....|....*....|....*....|....*..
gi 488994162 280 TAPLIGPRTVEQLQQALHATTV-TLSDDTMSCLDEIW 315
Cdd:cd19104 285 STVLVGVKNREELEEAVAAEAAgPLPAENLARLEALW 321
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
3-309 |
1.87e-37 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 135.66 E-value: 1.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 3 YTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGTEqspdiqqgSGLSEEIIGRWLQQ--G 79
Cdd:cd19150 2 YRRCGKSGLKLPALSLGLwHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGPP--------PGSAEENFGRILREdfA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 GRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIG 159
Cdd:cd19150 74 GYRDELIISTKAGYDMWPGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 SSNFAGWdiATAQSVATARHF-LGLVAEQSLYNLTARTIE-LEVIPACRHFGLGLIPWSPLAGGLLGG-------VLKKM 230
Cdd:cd19150 154 ISSYSPE--RTREAAAILRELgTPLLIHQPSYNMLNRWVEeSGLLDTLQELGVGCIAFTPLAQGLLTDkylngipEGSRA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 231 ASGRRARPAFarLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA-TTVTLSDDTMS 309
Cdd:cd19150 232 SKERSLSPKM--LTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGAlDNLTFSADELA 309
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-306 |
7.63e-37 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 133.83 E-value: 7.63e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTMNFGDV---TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQ 77
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGASPLGGVfgpVDEEEAIRTVHEALDSGINYIDTAPWYG----------QGRSETVLGKALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 78 qGGRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHI----DRHTPWEEIWQAMELLVQQG 153
Cdd:cd19163 71 -GIPRDSYYLATKVGRYGLDPDKMFDFSAERITKSVEESLKRLGLDYIDIIQVHDIefapSLDQILNETLPALQKLKEEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 154 KVLYIGSSnfaGWDIataqsvatarHFLGLVAEQSL-----------YNLTARTIeLEVIPACRHFGLGLIPWSPlaggl 222
Cdd:cd19163 150 KVRFIGIT---GYPL----------DVLKEVLERSPvkidtvlsychYTLNDTSL-LELLPFFKEKGVGVINASP----- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 223 lggvlkkMASG----RRAR---PAFARLIEQYRpqlEAYEgLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQA 295
Cdd:cd19163 211 -------LSMGllteRGPPdwhPASPEIKEACA---KAAA-YCKSRGVDISKLALQFALSNPDIATTLVGTASPENLRKN 279
|
330
....*....|.
gi 488994162 296 LHATTVTLSDD 306
Cdd:cd19163 280 LEAAEEPLDAH 290
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
3-299 |
5.03e-36 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 132.14 E-value: 5.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 3 YTHLGRTGLKVSRLCLGTM-NFGDVTDEKTSASILDEALEAGINFIDTADVYGteqSPdiqqgSGLSEEIIGRWLQQG-- 79
Cdd:cd19151 2 YNRCGRSGLKLPAISLGLWhNFGDVDRYENSRAMLRRAFDLGITHFDLANNYG---PP-----PGSAEENFGRILKEDlk 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 GRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIG 159
Cdd:cd19151 74 PYRDELIISTKAGYTMWPGPYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 160 SSNFagwdiaTAQSVATARHFLG-----LVAEQSLYNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASG- 233
Cdd:cd19151 154 ISNY------PPEEAREAAAILKdlgtpCLIHQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSP------------LAQGl 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 234 -------------RRARP-AFAR-------LIEQYRpQLEAyegLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQL 292
Cdd:cd19151 216 ltdrylngipedsRAAKGsSFLKpeqiteeKLAKVR-RLNE---IAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQI 291
|
....*..
gi 488994162 293 QQALHAT 299
Cdd:cd19151 292 EDAVGAL 298
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
10-314 |
1.40e-34 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 126.71 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNfgdVTDEKTSASILdEALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGG-RRERIVLA 88
Cdd:COG0656 2 GVEIPALGLGTWQ---LPGEEAAAAVR-TALEAGYRHIDTAAMYG-------------NEEGVGEAIAASGvPREELFVT 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYqpmgpgPNDrrLSAYHIRKACEDSLRRLKTDHIDVYQMHhidrhtpW------EEIWQAMELLVQQGKVLYIGSSN 162
Cdd:COG0656 65 TKVW------NDN--HGYDDTLAAFEESLERLGLDYLDLYLIH-------WpgpgpyVETWRALEELYEEGLIRAIGVSN 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 163 FAGWDIATAQSVATARhflgLVAEQSLYNLTARtiELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRAR-PAFA 241
Cdd:COG0656 130 FDPEHLEELLAETGVK----PAVNQVELHPYLQ--QRELLAFCREHGIVVEAYSP------------LGRGKLLDdPVLA 191
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 242 RLIEQYrpqleayeglcedlGETPSDVALAWLLQNPVVTaplIgPRTV--EQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:COG0656 192 EIAEKH--------------GKTPAQVVLRWHLQRGVVV---I-PKSVtpERIRENLDAFDFELSDEDMAAIDAL 248
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-314 |
2.08e-34 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 128.28 E-value: 2.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGT-MNFGDVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQG 79
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTwVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYA----------AGKAEVVLGNIIKKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 80 G-RRERIVLATKVYQPmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYI 158
Cdd:cd19158 71 GwRRSSLVITTKIFWG-GKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYW 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 159 GSSNFAGWDIATAQSVATARHFLGLVAEQSLYNLTAR-TIELEVIPACRHFGLGLIPWSPLAGGllggvlkkMASGR--R 235
Cdd:cd19158 150 GTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQReKVEVQLPELFHKIGVGAMTWSPLACG--------IVSGKydS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 236 ARPAFAR-------------LIEQYRPQ---LEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHAT 299
Cdd:cd19158 222 GIPPYSRaslkgyqwlkdkiLSEEGRRQqakLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAI 301
|
330
....*....|....*..
gi 488994162 300 TV--TLSDDTMSCLDEI 314
Cdd:cd19158 302 QVlpKLSSSIVHEIDSI 318
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
10-312 |
1.40e-33 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 124.22 E-value: 1.40e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFG-----DVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQGgRRER 84
Cdd:cd19137 1 GEKIPALGLGTWGIGgfltpDYSRDEEMVELLKTAIELGYTHIDTAEMYG----------GGHTEELVGKAIKDF-PRED 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 85 IVLATKVYQpmgpgpndRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19137 70 LFIVTKVWP--------TNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 GWDIATAQSVATArhflGLVAEQSLYNLTARTIELE-VIPACRHFGLGLIPWSPlaggllggvlkkmasgrrarpaFARL 243
Cdd:cd19137 142 RRLLEEAISKSQT----PIVCNQVKYNLEDRDPERDgLLEYCQKNGITVVAYSP----------------------LRRG 195
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 244 IEqyrPQLEAYEGLCEDLGETPSDVALAWLLQNP-VVTAPLIGprTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19137 196 LE---KTNRTLEEIAKNYGKTIAQIALAWLIQKPnVVAIPKAG--RVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-313 |
1.54e-32 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 123.56 E-value: 1.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRTGLKVSRLCLGTM-NFGDVTDEKTSASILDEALEAGINFIDTADVYGTEqspdiqqgSGLSEEIIGRWLQQ- 78
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGLWhNFGHVNALESQRAILRKAFDLGITHFDLANNYGPP--------PGSAEENFGRLLREd 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 79 -GGRRERIVLATKVYQPMGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLY 157
Cdd:PRK09912 85 fAAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 158 IGSSNFAgwDIATAQSVATARHF-LGLVAEQSLYNLTARTIELE-VIPACRHFGLGLIPWSPLAGGLLG--------GVL 227
Cdd:PRK09912 165 VGISSYS--PERTQKMVELLREWkIPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLLTgkylngipQDS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 228 KKMASGRRARPAFARLI-EQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA-TTVTLSD 305
Cdd:PRK09912 243 RMHREGNKVRGLTPKMLtEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQAlNNLTFST 322
|
....*...
gi 488994162 306 DTMSCLDE 313
Cdd:PRK09912 323 EELAQIDQ 330
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-298 |
1.44e-31 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 118.82 E-value: 1.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNF----GDVTDEKTSASILDEALEAGINFIDTADVYgteqspdiqqGSGLSEEIIGRWLQQGGrRERIVLAT 89
Cdd:cd19096 1 SVLGFGTMRLpesdDDSIDEEKAIEMIRYAIDAGINYFDTAYGY----------GGGKSEEILGEALKEGP-REKFYLAT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 90 KVyqpmgpgPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTpWEE------IWQAMELLVQQGKVLYIGSSnf 163
Cdd:cd19096 70 KL-------PPWSVKSAEDFRRILEESLKRLGVDYIDFYLLHGLNSPE-WLEkarkggLLEFLEKAKKEGLIRHIGFS-- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 164 agwdiataqSVATARHFLGLVAE------QSLYNL-----TARTielEVIPACRHFGLGLIPWSPlaggllggvlkkMAS 232
Cdd:cd19096 140 ---------FHDSPELLKEILDSydfdfvQLQYNYldqenQAGR---PGIEYAAKKGMGVIIMEP------------LKG 195
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488994162 233 GRRARPAFARLIEqyrpqleayegLCEDlGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:cd19096 196 GGLANNPPEALAI-----------LCGA-PLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAA 249
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-298 |
2.41e-30 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 115.70 E-value: 2.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFG---------DVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGRWLQqggRRER 84
Cdd:cd19097 1 SKLALGTAQFGldygianksGKPSEKEAKKILEYALKAGINTLDTAPAYGD------------SEKVLGKFLK---RLDK 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 85 IVLATKVyqpmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPW-EEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19097 66 FKIITKL----PPLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPDDLLKHgGKLVEALLELKKEGLIRKIGVSVY 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 164 AGWDIATaqsvATARHFLGLVaeQSLYN--------------LTARTIELevipacrH----F--GLGLIPwsplaggll 223
Cdd:cd19097 142 SPEELEK----ALESFKIDII--QLPFNildqrflksgllakLKKKGIEI-------HarsvFlqGLLLME--------- 199
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 224 ggvlkkmasgRRARPAFarlIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:cd19097 200 ----------PDKLPAK---FAPAKPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAA 261
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-296 |
1.57e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 112.03 E-value: 1.57e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 11 LKVSRLCLGT--MNFGDVTDEKtSASILDEALEAGINFIDTADVYgteqspdiqqGSGLSEEIIGRWLQQ-----GGRRE 83
Cdd:cd19099 1 LTLSSLGLGTyrGDSDDETDEE-YREALKAALDSGINVIDTAINY----------RGGRSERLIGKALREliekgGIKRD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 84 RIVLATKV--YQPMGPGPNDRRLSAYH-----------------------IRKACEDSLRRLKTDHIDVYQMH------- 131
Cdd:cd19099 70 EVVIVTKAgyIPGDGDEPLRPLKYLEEklgrglidvadsaglrhcispayLEDQIERSLKRLGLDTIDLYLLHnpeeqll 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 132 HIDRHTPW---EEIWQAMELLVQQGKVLYIG-SSNFAGWD-------------IATAQSVATARHFLGLVaeQSLYNL-- 192
Cdd:cd19099 150 ELGEEEFYdrlEEAFEALEEAVAEGKIRYYGiSTWDGFRAppalpghlsleklVAAAEEVGGDNHHFKVI--QLPLNLle 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 193 ----TARTIE----LEVIPACRHFGLGLipwsplaggllggvlkkMASgrraRPAFA-RLIEQYRPQLEAYeglcEDLGE 263
Cdd:cd19099 228 pealTEKNTVkgeaLSLLEAAKELGLGV-----------------IAS----RPLNQgQLLGELRLADLLA----LPGGA 282
|
330 340 350
....*....|....*....|....*....|...
gi 488994162 264 TPSDVALAWLLQNPVVTAPLIGPRTVEQLQQAL 296
Cdd:cd19099 283 TLAQRALQFARSTPGVDSALVGMRRPEHVDENL 315
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-314 |
1.37e-27 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 109.25 E-value: 1.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNF----GDVTDEKTSASILdEALEAGINFIDTADVYGTeqsPDIQqgsgLSEEIIGRWLQQGGR-RE 83
Cdd:cd19077 1 NGKLVGPIGLGLMGLtwrpNPTPDEEAFETMK-AALDAGSNLWNGGEFYGP---PDPH----ANLKLLARFFRKYPEyAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 84 RIVLATKVyqPMGPGPNDRRLSAYHIRKACEDSLRRLK-TDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSN 162
Cdd:cd19077 73 KVVLSVKG--GLDPDTLRPDGSPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 163 fagwdiATAQSVATARHFLGLVAEQSLYNLTARTIEL-EVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASGrrarPAFA 241
Cdd:cd19077 151 ------VSAETIRRAHAVHPIAAVEVEYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGLLTGRIKSLADI----PEGD 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 242 RLIEQYRPQLEAYEG----------LCEDLGETPSDVALAWLL-QNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMsc 310
Cdd:cd19077 221 FRRHLDRFNGENFEKnlklvdalqeLAEKKGCTPAQLALAWILaQSGPKIIPIPGSTTLERVEENLKAANVELTDEEL-- 298
|
....
gi 488994162 311 lDEI 314
Cdd:cd19077 299 -KEI 301
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
15-312 |
5.74e-27 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 106.41 E-value: 5.74e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 15 RLCLGTMNfgdVTDEKTSASILdEALEAGINFIDTADVYGTEqspdiqqgsglseEIIGRWLQQGG-RRERIVLATKVyq 93
Cdd:cd19071 3 LIGLGTYK---LKPEETAEAVL-AALEAGYRHIDTAAAYGNE-------------AEVGEAIRESGvPREELFITTKL-- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 94 pmgpgPNDRRLSAyHIRKACEDSLRRLKTDHIDVYQMH------HIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFagwd 167
Cdd:cd19071 64 -----WPTDHGYE-RVREALEESLKDLGLDYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNF---- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 168 iataqsvaTARHFLGLVAeqslynlTART------IEL-------EVIPACRHFGLGLIPWSPlaggllggvlkkMASGR 234
Cdd:cd19071 134 --------NVEHLEELLA-------AARIkpavnqIELhpylqqkELVEFCKEHGIVVQAYSP------------LGRGR 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 235 RARPAFARLIEqyrpqleayegLCEDLGETPSDVALAWLLQNPVVTApligPRTV--EQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19071 187 RPLLDDPVLKE-----------IAKKYGKTPAQVLLRWALQRGVVVI----PKSSnpERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-313 |
1.13e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 106.65 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 19 GTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsGLSEEIIGRWLQQgGRRERIVLATKvYQPMGPG 98
Cdd:cd19103 21 GDQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGM----------GASEKILGEFLKR-YPREDYIISTK-FTPQIAG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 99 PndrrlSAYHIRKACEDSLRRLKTDHIDVYQMHH---IDRHTPweeiwqamEL--LVQQGKVLYIGSSNFAGWDIATAQS 173
Cdd:cd19103 89 Q-----SADPVADMLEGSLARLGTDYIDIYWIHNpadVERWTP--------ELipLLKSGKVKHVGVSNHNLAEIKRANE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 174 VaTARHFLGLVAEQSLYNLTAR-TIELEVIPACRHFGLGLIPWsplaggllGGVLKKMASGRRAR----PAFARLIEQYR 248
Cdd:cd19103 156 I-LAKAGVSLSAVQNHYSLLYRsSEEAGILDYCKENGITFFAY--------MVLEQGALSGKYDTkhplPEGSGRAETYN 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488994162 249 ---PQLEAYEGLCEDLGE----TPSDVALAWLLQNPVVtaPLIGPRTVEQLQQALHATTVTLSDDTMSCLDE 313
Cdd:cd19103 227 pllPQLEELTAVMAEIGAkhgaSIAQVAIAWAIAKGTT--PIIGVTKPHHVEDAARAASITLTDDEIKELEQ 296
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
8-314 |
6.41e-26 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 103.49 E-value: 6.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 8 RTGLKVSRLCLGTMNFGDvtdeKTSASILDEALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIV 86
Cdd:cd19140 3 VNGVRIPALGLGTYPLTG----EECTRAVEHALELGYRHIDTAQMYGNEAQ-------------VGEAIAASGvPRDELF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKVyqpmgpGPNDrrLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGW 166
Cdd:cd19140 66 LTTKV------WPDN--YSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 167 DIATAQSVATARhflgLVAEQSLYNLTARtiELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRAR-PAFARLIE 245
Cdd:cd19140 138 LLREAVELSEAP----LFTNQVEYHPYLD--QRKLLDAAREHGIALTAYSP------------LARGEVLKdPVLQEIGR 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 246 QYrpqleayeglcedlGETPSDVALAWLLQNPVVTApLIGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19140 200 KH--------------GKTPAQVALRWLLQQEGVAA-IPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
14-298 |
2.86e-25 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 102.82 E-value: 2.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFGDV--TDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQqGGRRERIVLATKV 91
Cdd:cd19162 1 PRLGLGAASLGNLarAGEDEAAATLDAAWDAGIRYFDTAPLYG----------LGLSERRLGAALA-RHPRAEYVVSTKV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 92 ------YQPMGPGPNDRR--LSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRH--TPWEEIWQAMELLVQQGKVLYIGss 161
Cdd:cd19162 70 grllepGAAGRPAGADRRfdFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHllQALTDAFPALEELRAEGVVGAIG-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 162 nFAGWDIATA-QSVATARHFLGLVAEQslYNLTARTIELEVIPACRHFGLGLIPWSPLAGGLlggvlkkMASGRRARPAF 240
Cdd:cd19162 148 -VGVTDWAALlRAARRADVDVVMVAGR--YTLLDRRAATELLPLCAAKGVAVVAAGVFNSGI-------LATDDPAGDRY 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 241 arlieQYRP-------QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHA 298
Cdd:cd19162 218 -----DYRPatpevlaRARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLAL 277
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
10-275 |
1.74e-24 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 100.00 E-value: 1.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGT-----MNFGDVTDEKTSASILdEALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQ-GGRRE 83
Cdd:cd19120 1 GSKIPAIAFGTgtawyKSGDDDIQRDLVDSVK-LALKAGFRHIDTAEMYGNEKE-------------VGEALKEsGVPRE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 84 RIVLATKVYQPMGpgpndrrlsayHIRKACEDSLRRLKTDHIDVYQMHH-----IDRHTPwEEIWQAMELLVQQGKVLYI 158
Cdd:cd19120 67 DLFITTKVSPGIK-----------DPREALRKSLAKLGVDYVDLYLIHSpffakEGGPTL-AEAWAELEALKDAGLVRSI 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 159 GSSNFAGWDIATAqsVATARHFlgLVAEQSLYN--LTARTIELevIPACRHFGLGLIPWSPlaggllggvlkkMASGRRA 236
Cdd:cd19120 135 GVSNFRIEDLEEL--LDTAKIK--PAVNQIEFHpyLYPQQPAL--LEYCREHGIVVSAYSP------------LSPLTRD 196
|
250 260 270
....*....|....*....|....*....|....*....
gi 488994162 237 RPafarlieqyRPQLEAYEGLCEDLGETPSDVALAWLLQ 275
Cdd:cd19120 197 AG---------GPLDPVLEKIAEKYGVTPAQVLLRWALQ 226
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
29-312 |
8.83e-23 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 95.03 E-value: 8.83e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 29 EKTSASILDEALEAGINFIDTADVYGTEqspdiqqgSGLSEEIIgrwlQQGGRRERIVLATKVYQpmgpgpndRRLSAYH 108
Cdd:cd19073 13 GDDCANAVKEALELGYRHIDTAEIYNNE--------AEVGEAIA----ESGVPREDLFITTKVWR--------DHLRPED 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 109 IRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFagwdiataqsvaTARHfLGLVAEQS 188
Cdd:cd19073 73 LKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNF------------TIEL-LEEALDIS 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 189 LYNLTARTIEL-------EVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRarpafarlieqyrPQLEAYEGLCEDL 261
Cdd:cd19073 140 PLPIAVNQVEFhpflyqaELLEYCRENDIVITAYSP------------LARGEV-------------LRDPVIQEIAEKY 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 488994162 262 GETPSDVALAWLLQNPVVTAPliGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19073 195 DKTPAQVALRWLVQKGIVVIP--KASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
1-314 |
7.15e-22 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 93.50 E-value: 7.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 1 MNYTHLGRT----GLKVSRLCLGTMN------FGDVTDEKTSASILDEALEAGINFIDTADVYGteqsPDIqqgsglSEE 70
Cdd:PRK10376 1 MSTIMSSGTftlgGRSVNRLGYGAMQlagpgvFGPPKDRDAAIAVLREAVALGVNHIDTSDFYG----PHV------TNQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 71 IIGRWLQQGgrRERIVLATKVYQPMGP-GPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHI-DRHTPWEE-IWQAME 147
Cdd:PRK10376 71 LIREALHPY--PDDLTIVTKVGARRGEdGSWLPAFSPAELRRAVHDNLRNLGLDVLDVVNLRLMgDGHGPAEGsIEEPLT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 148 LLV---QQGKVLYIGSSNfagwdiATAQSVATARHFLGLVAEQSLYNLTARTIElEVIPACRHFGLGLIPWSPLAggllg 224
Cdd:PRK10376 149 VLAelqRQGLVRHIGLSN------VTPTQVAEARKIAEIVCVQNHYNLAHRADD-ALIDALARDGIAYVPFFPLG----- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 225 gvlkkmasgrrarpAFARLieqyrpQLEAYEGLCEDLGETPSDVALAWLLQNpvvtAPLI----GPRTVEQLQQALHATT 300
Cdd:PRK10376 217 --------------GFTPL------QSSTLSDVAASLGATPMQVALAWLLQR----SPNIllipGTSSVAHLRENLAAAE 272
|
330
....*....|....
gi 488994162 301 VTLSDDTMSCLDEI 314
Cdd:PRK10376 273 LVLSEEVLAELDGI 286
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
14-306 |
2.82e-21 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 91.90 E-value: 2.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFG----DVTDEKTSAsILDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQGGRrERIVLAT 89
Cdd:cd19152 1 PKLGFGTAPLGnlyeAVSDEEAKA-TLVAAWDLGIRYFDTAPWYG----------AGLSEERLGAALRELGR-EDYVIST 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 90 KV---YQP-MGPGPNDRRL-------------SAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEE----------- 141
Cdd:cd19152 69 KVgrlLVPlQEVEPTFEPGfwnplpfdavfdySYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAEsdehfaqaikg 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 142 IWQAMELLVQQGKVLYIG-SSNFagWDIAtAQSVATARHFLGLVAEQ-SLYNLTArtiELEVIPACRHFGLGLIPWSPla 219
Cdd:cd19152 149 AFRALEELREEGVIKAIGlGVND--WEVI-LRILEEADLDWVMLAGRyTLLDHSA---ARELLPECEKRGVKVVNAGP-- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 220 ggllggvlkkMASGRRARPAFARLIEqYRP-------QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQL 292
Cdd:cd19152 221 ----------FNSGFLAGGDNFDYYE-YGPappeliaRRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERV 289
|
330
....*....|....
gi 488994162 293 QQALHATTVTLSDD 306
Cdd:cd19152 290 EENVALLATEIPAA 303
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
3-316 |
2.19e-19 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 86.76 E-value: 2.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 3 YTHLGRTGLKVSRLCLGTMN----FGDVTDEKTSASIlDEALEAGINFIDTADVYGteqspdiqqgSGLSEEIIGRWLQQ 78
Cdd:PLN02587 1 LRELGSTGLKVSSVGFGASPlgsvFGPVSEEDAIASV-REAFRLGINFFDTSPYYG----------GTLSEKVLGKALKA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 79 GG-RRERIVLATKVyqpmGPGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDrHTPWEEIWQ----AMELLVQQG 153
Cdd:PLN02587 70 LGiPREKYVVSTKC----GRYGEGFDFSAERVTKSVDESLARLQLDYVDILHCHDIE-FGSLDQIVNetipALQKLKESG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 154 KVLYIGssnfagwdiATAQSVATARHFLGLVAEQSL--------YNLTARTIElEVIPACRHFGLGLIPWSPlaggllgg 225
Cdd:PLN02587 145 KVRFIG---------ITGLPLAIFTYVLDRVPPGTVdvilsychYSLNDSSLE-DLLPYLKSKGVGVISASP-------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 226 vlkkMASG---RRARPAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQ----ALHA 298
Cdd:PLN02587 207 ----LAMGlltENGPPEWHPAPPELKSACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVEEnvaaATEL 282
|
330 340
....*....|....*....|....*.
gi 488994162 299 TTVTLSDDTMSCLDEI--------WP 316
Cdd:PLN02587 283 ETSGIDEELLSEVEAIlapvknktWP 308
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
10-314 |
1.58e-18 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 83.53 E-value: 1.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGDVTDEKTSASILdealEAGINFIDTADVYGTEqspdiqqgsglseEIIGRWLQQGG-RRERIVLA 88
Cdd:cd19135 10 GVEMPILGLGTSHSGGYSHEAVVYALK----ECGYRHIDTAKRYGCE-------------ELLGKAIKESGvPREDLFLT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYqpmgpgPNDrrLSAYHIRKACEDSLRRLKTDHIDVYQMH--------HIDRHTPwEEIWQAMELLVQQGKVLYIGS 160
Cdd:cd19135 73 TKLW------PSD--YGYESTKQAFEASLKRLGVDYLDLYLLHwpdcpssgKNVKETR-AETWRALEELYDEGLCRAIGV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 SNFAGWDIATAQSVATARHFLGLVaEQSLYNLtartiELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRR-ARPA 239
Cdd:cd19135 144 SNFLIEHLEQLLEDCSVVPHVNQV-EFHPFQN-----PVELIEYCRDNNIVFEGYCP------------LAKGKAlEEPT 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 240 FARLIEQYrpqleayeglcedlGETPSDVALAWLLQNPVVTAPliGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19135 206 VTELAKKY--------------QKTPAQILIRWSIQNGVVTIP--KSTKEERIKENCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
10-282 |
1.59e-18 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 83.59 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNfgdVTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGGR-RERIVLA 88
Cdd:cd19157 7 GVKMPWLGLGVFK---VEEGSEVVNAVKTALKNGYRSIDTAAIYG-------------NEEGVGKGIKESGIpREELFIT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYQpmGPGPNDRRLSAYhirkacEDSLRRLKTDHIDVYQMHHiDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDI 168
Cdd:cd19157 71 SKVWN--ADQGYDSTLKAF------EASLERLGLDYLDLYLIHW-PVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 169 ATAQSVATARHFLGLVaeqslyNLTARTIELEVIPACRHFGLGLIPWSPLaggllggvlkkMASGRRARPAFARLIEQYr 248
Cdd:cd19157 142 EDLLADAEIVPMVNQV------EFHPRLTQKELRDYCKKQGIQLEAWSPL-----------MQGQLLDNPVLKEIAEKY- 203
|
250 260 270
....*....|....*....|....*....|....
gi 488994162 249 pqleayeglcedlGETPSDVALAWLLQNPVVTAP 282
Cdd:cd19157 204 -------------NKSVAQVILRWDLQNGVVTIP 224
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
16-163 |
2.59e-18 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 83.49 E-value: 2.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 16 LCLGTmnFGDVTDEKTSASILDeALEAGINFIDTADVYGTEQspdiQQGSGLSEEIigrwlQQGG-RRERIVLATKVYQp 94
Cdd:cd19116 14 IALGT--WKLKDDEGVRQAVKH-AIEAGYRHIDTAYLYGNEA----EVGEAIREKI-----AEGVvKREDLFITTKLWN- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 95 mgpgpndrrlsAYHIRK----ACEDSLRRLKTDHIDVYQMH-------HIDRHTPWE---------EIWQAMELLVQQGK 154
Cdd:cd19116 81 -----------SYHEREqvepALRESLKRLGLDYVDLYLIHwpvafkeNNDSESNGDgslsdidylETWRGMEDLVKLGL 149
|
....*....
gi 488994162 155 VLYIGSSNF 163
Cdd:cd19116 150 TRSIGVSNF 158
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
24-315 |
2.59e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 83.80 E-value: 2.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 24 GDVTDEKTSASILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGR----WLQQGGRRERIVLATKVYqpmgPGP 99
Cdd:cd19101 17 GGIRDEDAAVRAMAAYVDAGLTTFDCADIYGP------------AEELIGEfrkrLRRERDAADDVQIHTKWV----PDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 100 NDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTP-WEEIWQAMELLVQQGKVLYIGSSNFagwDIATAQSVATAR 178
Cdd:cd19101 81 GELTMTRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNF---DTERLREILDAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 179 hfLGLVAEQSLYNLTARTIELEVIPACRHFGLGLIPW----------------SPlaggllggvlKKMASGRRARPAFAR 242
Cdd:cd19101 158 --VPIVSNQVQYSLLDRRPENGMAALCEDHGIKLLAYgtlaggllsekylgvpEP----------TGPALETRSLQKYKL 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 243 LIEQ------YRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEIW 315
Cdd:cd19101 226 MIDEwggwdlFQELLRTLKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDAVL 304
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
18-163 |
2.67e-17 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 79.98 E-value: 2.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 18 LGTMNfgdVTDEKTSASILDEALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-----RRERIVLATKVy 92
Cdd:cd19136 6 LGTFR---LRGEEEVRQAVDAALKAGYRLIDTASVYRNEAD-------------IGKALRDLLpkyglSREDIFITSKL- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 93 qpmgpGPNDRRLSAyhIRKACEDSLRRLKTDHIDVYQMH-------------HID-RHtpweEIWQAMELLVQQGKVLYI 158
Cdd:cd19136 69 -----APKDQGYEK--ARAACLGSLERLGTDYLDLYLIHwpgvqglkpsdprNAElRR----ESWRALEDLYKEGKLRAI 137
|
....*
gi 488994162 159 GSSNF 163
Cdd:cd19136 138 GVSNY 142
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
13-314 |
3.87e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 79.32 E-value: 3.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 13 VSRLCLGTmnFGdVTDEKTSASILDeALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIVLATKV 91
Cdd:cd19139 1 IPAFGLGT--FR-LKDDVVIDSVRT-ALELGYRHIDTAQIYDNEAA-------------VGQAIAESGvPRDELFITTKI 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 92 YQpmgpgpndRRLSAYHIRKACEDSLRRLKTDHIDVYQMH--HIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIA 169
Cdd:cd19139 64 WI--------DNLSKDKLLPSLEESLEKLRTDYVDLTLIHwpSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLD 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 170 TAQSVATARHFLGLVAEQSLYnLTARTieleVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRAR-PAFARLIEQYr 248
Cdd:cd19139 136 EAIAVVGAGAIATNQIELSPY-LQNRK----LVAHCKQHGIHVTSYMT------------LAYGKVLDdPVLAAIAERH- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488994162 249 pqleayeglcedlGETPSDVALAWLLQNPVVTAPliGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19139 198 -------------GATPAQIALAWAMARGYAVIP--SSTKREHLRSNLLALDLTLDADDMAAIAAL 248
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
10-314 |
4.88e-17 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 79.85 E-value: 4.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGdvTDEKTSAsiLDEALEAGINFIDTADVYGTEQSPDiqqgsglseEIIGRWLQQGG-RRERIVLA 88
Cdd:cd19111 1 GFPMPVIGLGTYQSP--PEEVRAA--VDYALFVGYRHIDTALSYQNEKAIG---------EALKWWLKNGKlKREEVFIT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYqPMGpgpndrrLSAYHIRKACEDSLRRLKTDHIDVYQMHH-------------IDRHTPWEEIWQAMELLVQQGKV 155
Cdd:cd19111 68 TKLP-PVY-------LEFKDTEKSLEKSLENLKLPYVDLYLIHHpcgfvnkkdkgerELASSDVTSVWRAMEALVSEGKV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 156 LYIGSSNFAGWDIATAqsVATARHFL-GLVAEQSLYnLTARtielEVIPACRHFGLGLIPWSPLaggllggvlkkmasGR 234
Cdd:cd19111 140 KSIGLSNFNPRQINKI--LAYAKVKPsNLQLECHAY-LQQR----ELRKFCNKKNIVVTAYAPL--------------GS 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 235 RARPAFARLIEQYRP-QLEAYEGLCEDLGETPSDVALAWLLQNPvvTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDE 313
Cdd:cd19111 199 PGRANQSLWPDQPDLlEDPTVLAIAKELDKTPAQVLLRFVLQRG--TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKT 276
|
.
gi 488994162 314 I 314
Cdd:cd19111 277 L 277
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
39-312 |
2.76e-16 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 77.81 E-value: 2.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQspdiQQGSGLSEEIIGrwlQQGGRRERIVLATKVYQPMGpGPNDrrlsayhIRKACEDSLR 118
Cdd:cd19106 29 ALDAGYRHIDCAAVYGNEQ----EVGEALKEKVGP---GKAVPREDLFVTSKLWNTKH-HPED-------VEPALRKTLK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 119 RLKTDHIDVYQMH------HID-----------RH--TPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIATAQSVATARH 179
Cdd:cd19106 94 DLQLDYLDLYLIHwpyafeRGDnpfpknpdgtiRYdsTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 180 FLgLVAEQSLYnLTartiELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRR--ARPAFARLIEQyrPQLEAyegL 257
Cdd:cd19106 174 AV-LQVECHPY-LA----QNELIAHCKARGLVVTAYSP------------LGSPDRpwAKPDEPVLLEE--PKVKA---L 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 258 CEDLGETPSDVALAWLLQNPVVTAPliGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19106 231 AKKYNKSPAQILLRWQVQRGVVVIP--KSVTPSRIKQNIQVFDFTLSPEEMKQLD 283
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
14-298 |
2.83e-16 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 78.14 E-value: 2.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 14 SRLCLGTMNFG----DVTdEKTSASILDEALEAGINFIDTADVYgteqspdiqqGSGLSEEIIGRWLQQGGrRERIVLAT 89
Cdd:cd19161 1 SELGLGTAGLGnlytAVS-NADADATLDAAWDSGIRYFDTAPMY----------GHGLAEHRLGDFLREKP-RDEFVLST 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 90 KVYQPMGPGPNDRRL-----------------SAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEE---IW------ 143
Cdd:cd19161 69 KVGRLLKPAREGSVPdpngfvdplpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRkerHHfaqlms 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 144 ---QAMELLVQQGKVLYIGssnfAG---WDIAtaqsVATARHF---LGLVAEQslYNLTARTIELEVIPACRHFGLGLIP 214
Cdd:cd19161 149 ggfKALEELKKAGVIKAFG----LGvneVQIC----LEALDEAdldCFLLAGR--YSLLDQSAEEEFLPRCEQRGTSLVI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 215 WSPlaggllggvlkkMASGRRARPAFARLIEQYRP-------QLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPR 287
Cdd:cd19161 219 GGV------------FNSGILATGTKSGAKFNYGDapaeiisRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGAR 286
|
330
....*....|.
gi 488994162 288 TVEQLQQALHA 298
Cdd:cd19161 287 NPAQLRQNVEA 297
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
8-314 |
3.44e-16 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 77.45 E-value: 3.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 8 RTGLKVSRLCLGTMNFGdvtdEKTSASILDEALEAGINFIDTADVYGTEQspdiQQGSGLSEEiigrwLQQGG-RRERIV 86
Cdd:cd19123 7 SNGDLIPALGLGTWKSK----PGEVGQAVKQALEAGYRHIDCAAIYGNEA----EIGAALAEV-----FKEGKvKREDLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKVYqpmgpgpNDRRLSAyHIRKACEDSLRRLKTDHIDVYQMH------------------HIDRHTPWEEIWQAMEL 148
Cdd:cd19123 74 ITSKLW-------NNSHAPE-DVLPALEKTLADLQLDYLDLYLMHwpvalkkgvgfpesgedlLSLSPIPLEDTWRAMEE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 149 LVQQGKVLYIGSSNFAGWDIATAqsVATARHFLGLvaeqslynltaRTIEL-------EVIPACRHFGLGLIPWSPlagg 221
Cdd:cd19123 146 LVDKGLCRHIGVSNFSVKKLEDL--LATARIKPAV-----------NQVELhpylqqpELLAFCRDNGIHLTAYSP---- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 222 llggvlkkMASGRRARPAFA----RLIEQyrPQLeayEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRtvEQLQQALH 297
Cdd:cd19123 209 --------LGSGDRPAAMKAegepVLLED--PVI---NKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNP--ERIQQNLE 273
|
330
....*....|....*..
gi 488994162 298 ATTVTLSDDTMSCLDEI 314
Cdd:cd19123 274 AAEVELDASDMATIAAL 290
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
39-314 |
3.78e-16 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 76.71 E-value: 3.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIVLATKVY-QPMGpgpNDRRLSAYHirkaceDS 116
Cdd:cd19126 32 ALENGYRSIDTAAIYKNEEG-------------VGEAIRESGvPREELFVTTKLWnDDQR---ARRTEDAFQ------ES 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 117 LRRLKTDHIDVYQMHHIDRHTpWEEIWQAMELLVQQGKVLYIGSSNFAGWDI----ATAQSVATARHFlglvaEQSLYnL 192
Cdd:cd19126 90 LDRLGLDYVDLYLIHWPGKDK-FIDTWKALEKLYASGKVKAIGVSNFQEHHLeellAHADVVPAVNQV-----EFHPY-L 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 193 TARtielEVIPACRHFGLGLIPWSPLaggllggvlkkMASGRRARPAFARLIEQYrpqleayeglcedlGETPSDVALAW 272
Cdd:cd19126 163 TQK----ELRGYCKSKGIVVEAWSPL-----------GQGGLLSNPVLAAIGEKY--------------GKSAAQVVLRW 213
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 488994162 273 LLQNPVVTApligPRTV--EQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19126 214 DIQHGVVTI----PKSVhaSRIKENADIFDFELSEDDMTAIDAL 253
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
13-298 |
6.25e-16 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 76.93 E-value: 6.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 13 VSRLCLGTMNFG-DVTDEKTS---ASILDEALEAGINFIDTADVYGTeqspdiqqgsglSEEIIGRWLQ---QGGRRERI 85
Cdd:cd19164 13 LPPLIFGAATFSyQYTTDPESippVDIVRRALELGIRAFDTSPYYGP------------SEIILGRALKalrDEFPRDTY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKV--YqpmgpGPNDRRLSAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPwEEIWQAMELLVQ---QGKVLYIGs 160
Cdd:cd19164 81 FIITKVgrY-----GPDDFDYSPEWIRASVERSLRRLHTDYLDLVYLHDVEFVAD-EEVLEALKELFKlkdEGKIRNVG- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 161 snFAGWDIATAQSVAT-ARHFLG----LVAEQSLYNLTARTI-----------ELEVIPACRHFGLGLI------PWSPl 218
Cdd:cd19164 154 --ISGYPLPVLLRLAElARTTAGrpldAVLSYCHYTLQNTTLlayipkflaaaGVKVVLNASPLSMGLLrsqgppEWHP- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 219 aggllggvlkkmaSGRRARPAFARLIEqyrpqleayegLCEDLGETPSDVALAWLLQNPV-VTAPLIGPRTVEQLQQALH 297
Cdd:cd19164 231 -------------ASPELRAAAAKAAE-----------YCQAKGTDLADVALRYALREWGgEGPTVVGCSNVDELEEAVE 286
|
.
gi 488994162 298 A 298
Cdd:cd19164 287 A 287
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
6-300 |
2.76e-15 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 74.88 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 6 LGRTGLKVSRLCLGTMNFGDV-TDEKTS---ASILDEALEAGINFIDTADVYGTEqspdiqqgsgLSEEIIGRWLQQGG- 80
Cdd:cd19153 5 LEIALGNVSPVGLGTAALGGVyGDGLEQdeaVAIVAEAFAAGINHFDTSPYYGAE----------SSEAVLGKALAALQv 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 81 RRERIVLATKVYQPMGPGPNdrrLSAYHIRKACEDSLRRLKTDHIDVYQMHHI---DRHTPWEEIWQAMELLVQQGKVLY 157
Cdd:cd19153 75 PRSSYTVATKVGRYRDSEFD---YSAERVRASVATSLERLHTTYLDVVYLHDIefvDYDTLVDEALPALRTLKDEGVIKR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 158 IGssnFAGWDIATAQSVATARHFLGLVAEQSLYNLTARTIELEvipacrhfglGLIPWSPLAGGLLGGVLKKMASG---R 234
Cdd:cd19153 152 IG---IAGYPLDTLTRATRRCSPGSLDAVLSYCHLTLQDARLE----------SDAPGLVRGAGPHVINASPLSMGlltS 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488994162 235 RARPAFARLIEQYRPQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAP-LIGPRTVEQLQQALHATT 300
Cdd:cd19153 219 QGPPPWHPASGELRHYAAAADAVCASVEASLPDLALQYSLAAHAGVGTvLLGPSSLAQLRSMLAAVD 285
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
26-282 |
8.21e-15 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 73.18 E-value: 8.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 26 VTDEKTsASILDEALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGG-RRERIVLATKVYQpmgpgpNDRRL 104
Cdd:cd19131 20 VSNDEA-ASAVREALEVGYRSIDTAAIYG-------------NEEGVGKAIRASGvPREELFITTKLWN------SDQGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 105 SAyhIRKACEDSLRRLKTDHIDVYQMH----HIDRHTpweEIWQAMELLVQQGKVLYIGSSNFagwdiataqsvaTARHF 180
Cdd:cd19131 80 DS--TLRAFDESLRKLGLDYVDLYLIHwpvpAQDKYV---ETWKALIELKKEGRVKSIGVSNF------------TIEHL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 181 lglvaeQSLYNLTART-----IEL-------EVIPACRHFGLGLIPWSPlaggllggvlkkMASGRR-ARPAFARLIEQY 247
Cdd:cd19131 143 ------QRLIDETGVVpvvnqIELhprfqqrELRAFHAKHGIQTESWSP------------LGQGGLlSDPVIGEIAEKH 204
|
250 260 270
....*....|....*....|....*....|....*
gi 488994162 248 rpqleayeglcedlGETPSDVALAWLLQNPVVTAP 282
Cdd:cd19131 205 --------------GKTPAQVVIRWHLQNGLVVIP 225
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
15-314 |
1.68e-14 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 72.56 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 15 RLCLGTMNFGDVTDEKTsasiLDEALEAGINFIDTADVYGTEQSpdiqQGSGLSEEIigrwLQQGGRRERIVLATKVYQP 94
Cdd:cd19128 3 RLGFGTYKITESESKEA----VKNAIKAGYRHIDCAYYYGNEAF----IGIAFSEIF----KDGGVKREDLFITSKLWPT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 95 MGPGPNdrrlsayhIRKACEDSLRRLKTDHIDVYQMH-------------------HIDRHTPWEEIWQAMELLVQQGKV 155
Cdd:cd19128 71 MHQPEN--------VKEQLLITLQDLQLEYLDLFLIHwplafdmdtdgdprddnqiQSLSKKPLEDTWRAMEQCVDEKLT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 156 LYIGSSNFAGWDIATAQSVATARHFLGLVaEQSLYNLTARTIELevipaCRHFGLGLIPWSPLaggllggvlkkmaSGRR 235
Cdd:cd19128 143 KNIGVSNYSTKLLTDLLNYCKIKPFMNQI-ECHPYFQNDKLIKF-----CIENNIHVTAYRPL-------------GGSY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 236 ARPAFARLIEqyrPQLEAyegLCEDLGETPSDVALAWLLQN-PVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19128 204 GDGNLTFLND---SELKA---LATKYNTTPPQVIIAWHLQKwPKNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
26-163 |
6.71e-14 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 70.49 E-value: 6.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 26 VTDEKTSASILdEALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGG-RRERIVLATKVYqpmgpgpNDRRL 104
Cdd:PRK11565 25 ASNEEVITAIH-KALEVGYRSIDTAAIYK-------------NEEGVGKALKEASvAREELFITTKLW-------NDDHK 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488994162 105 SAyhiRKACEDSLRRLKTDHIDVYQMH----HIDRHTpweEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:PRK11565 84 RP---REALEESLKKLQLDYVDLYLMHwpvpAIDHYV---EAWKGMIELQKEGLIKSIGVCNF 140
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
26-163 |
8.52e-14 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 69.91 E-value: 8.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 26 VTDEKTSASILDEALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGG-RRERIVLATKVY-QPMGPGPndrr 103
Cdd:cd19133 19 IPDPEECERAVLEAIKAGYRLIDTAAAYG-------------NEEAVGRAIKKSGiPREELFITTKLWiQDAGYEK---- 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488994162 104 lsayhIRKACEDSLRRLKTDHIDVYQMHHidrhtPW---EEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19133 82 -----AKKAFERSLKRLGLDYLDLYLIHQ-----PFgdvYGAWRAMEELYKEGKIRAIGVSNF 134
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
10-282 |
2.13e-13 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 69.48 E-value: 2.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNfgdVTDEKTSASIlDEALEAGINFIDTADVYGTEqspdiqqgsGLSEEIIGRWLQQGG-RRERIVLA 88
Cdd:cd19155 9 GEKMPVVGLGTWQ---SSPEEIETAV-DTALEAGYRHIDTAYVYRNE---------AAIGNVLKKWIDSGKvKREELFIV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVyqPMGpgpNDRRLSayhIRKACEDSLRRLKTDHIDVY---------------------QMHHIDRHTPWEEIWQAME 147
Cdd:cd19155 76 TKL--PPG---GNRREK---VEKFLLKSLEKLQLDYVDLYlihfpvgslskeddsgkldptGEHKQDYTTDLLDIWKAME 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 148 LLVQQGKVLYIGSSNFAGWDIATAQSVATARHfLGLVAEQSLYnLTARtielEVIPACRHFGLGLIPWSPLAGGLLGGVL 227
Cdd:cd19155 148 AQVDQGLTRSIGLSNFNREQMARILKNARIKP-ANLQVELHVY-LQQK----DLVDFCSTHSITVTAYAPLGSPGAAHFS 221
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 228 KKMASGRRARPAFArlieqyrpQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAP 282
Cdd:cd19155 222 PGTGSPSGSSPDLL--------QDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIP 268
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
10-314 |
1.15e-12 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 67.05 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTmnFGDVTDEKTSAsiLDEALEAGINFIDTADVYGTEQspdiQQGSGLSeeiigrwlQQGGRRERIVLAT 89
Cdd:cd19127 6 GVEMPALGLGV--FQTPPEETADA--VATALADGYRLIDTAAAYGNER----EVGEGIR--------RSGVDRSDIFVTT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 90 KVYqpmgpgpndrrLSAY---HIRKACEDSLRRLKTDHIDVYQMHHIDRHTpWE---EIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19127 70 KLW-----------ISDYgydKALRGFDASLRRLGLDYVDLYLLHWPVPND-FDrtiQAYKALEKLLAEGRVRAIGVSNF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 164 agwdiataqsvatarhflglvAEQSLYNLTARTielEVIPAC--------------RHF--GLGLI--PWSPlaggllgg 225
Cdd:cd19127 138 ---------------------TPEHLERLIDAT---TVVPAVnqvelhpyfsqkdlRAFhrRLGIVtqAWSP-------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 226 vlkkMASGRRARPAFARliEQYRP-QLEAYEGLCEDLGETPSDVALAWLLQNPVVTApligPRTV--EQLQQALHATTVT 302
Cdd:cd19127 186 ----IGGVMRYGASGPT--GPGDVlQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAI----PKSVhpERIAENIDIFDFA 255
|
330
....*....|..
gi 488994162 303 LSDDTMSCLDEI 314
Cdd:cd19127 256 LSAEDMAAIDAL 267
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
9-314 |
1.35e-12 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 67.05 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGT--MNFGDVTdektsaSILDEALEAGINFIDTADVYGTEQspdiQQGsglseEIIGRWLQQG-GRRERI 85
Cdd:cd19154 8 NGVKMPLIGLGTwqSKGAEGI------TAVRTALKAGYRLIDTAFLYQNEE----AIG-----EALAELLEEGvVKREDL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKVyqPMGpgpndrRLSAYHIRKACEDSLRRLKTDHIDVYQMH-------------------HIDRHTPWEEIWQAM 146
Cdd:cd19154 73 FITTKL--WTH------EHAPEDVEEALRESLKKLQLEYVDLYLIHapaafkddegesgtmengmSIHDAVDVEDVWRGM 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 147 ELLVQQGKVLYIGSSNFAGWDIATAQSVATARhflgLVAEQslynltartIEL-------EVIPACRHFGLGLIPWSPla 219
Cdd:cd19154 145 EKVYDEGLTKAIGVSNFNNDQIQRILDNARVK----PHNNQ---------VEChlyfpqkELVEFCKKHNISVTSYAT-- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 220 ggllggvlkkMAS-GRRARPAFARLIEQYRPQLEAYEG-LCEDLGETPSDVALAWLLQNPVVTAPLigPRTVEQLQQALH 297
Cdd:cd19154 210 ----------LGSpGRANFTKSTGVSPAPNLLQDPIVKaIAEKHGKTPAQVLLRYLLQRGIAVIPK--SATPSRIKENFN 277
|
330
....*....|....*..
gi 488994162 298 ATTVTLSDDTMSCLDEI 314
Cdd:cd19154 278 IFDFSLSEEDMATLEEI 294
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
9-275 |
3.71e-12 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 65.83 E-value: 3.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGT--MNFGDVTDEktsasiLDEALEAGINFIDTADVYGTEqspdIQQGSGLSEEIIGRWLqqggRRERIV 86
Cdd:cd19125 7 TGAKIPAVGLGTwqADPGVVGNA------VKTAIKEGYRHIDCAAIYGNE----KEIGKALKKLFEDGVV----KREDLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKVYqpmgpgpndrrlSAYH----IRKACEDSLRRLKTDHIDVYQMH-----HIDRHTPWEE---------IWQAMEL 148
Cdd:cd19125 73 ITSKLW------------CTDHapedVPPALEKTLKDLQLDYLDLYLIHwpvrlKKGAHMPEPEevlppdipsTWKAMEK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 149 LVQQGKVLYIGSSNFagwdiataqsvaTARHFLGLVAEqslynltARTI------EL-------EVIPACRHFGLGLIPW 215
Cdd:cd19125 141 LVDSGKVRAIGVSNF------------SVKKLEDLLAV-------ARVPpavnqvEChpgwqqdKLHEFCKSKGIHLSAY 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 216 SPLAGGLLGGVLKKMAsgrrarpafarlieqyrpQLEAYEGLCEDLGETPSDVALAWLLQ 275
Cdd:cd19125 202 SPLGSPGTTWVKKNVL------------------KDPIVTKVAEKLGKTPAQVALRWGLQ 243
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
9-164 |
4.96e-11 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 62.16 E-value: 4.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNfGDVTDEKTSASildEALEAGINFIDTADVYGTEQspdiQQGSGLSEEIIGrwlqqGGRRERIVLA 88
Cdd:cd19121 8 TGASIPAVGLGTWQ-AKAGEVKAAVA---HALKIGYRHIDGALCYQNED----EVGEGIKEAIAG-----GVKREDLFVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYqpmgpgpndrrlSAYHIR--KACEDSLRRLKTDHIDVYQMH----------------HID--RHTPWE----EIWQ 144
Cdd:cd19121 75 TKLW------------STYHRRveLCLDRSLKSLGLDYVDLYLVHwpvllnpngnhdlfptLPDgsRDLDWDwnhvDTWK 142
|
170 180
....*....|....*....|
gi 488994162 145 AMELLVQQGKVLYIGSSNFA 164
Cdd:cd19121 143 QMEKVLKTGKTKAIGVSNYS 162
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
2-164 |
5.54e-11 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 62.13 E-value: 5.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 2 NYTHLGRTGLKVSRLCLGTMNFGDVTDEKTSASildeALEAGINFIDTADVYGTEQspdiQQGSGLSEeiigrwlqQGGR 81
Cdd:cd19117 3 SKTFKLNTGAEIPAVGLGTWQSKPNEVAKAVEA----ALKAGYRHIDTAAIYGNEE----EVGQGIKD--------SGVP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 82 RERIVLATKVYqpmgpgpndrrlSAYHIR-KACED-SLRRLKTDHIDVYQMH------------------HIDRHTP-WE 140
Cdd:cd19117 67 REEIFITTKLW------------CTWHRRvEEALDqSLKKLGLDYVDLYLMHwpvpldpdgndflfkkddGTKDHEPdWD 134
|
170 180
....*....|....*....|....*.
gi 488994162 141 EI--WQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19117 135 FIktWELMQKLPATGKVKAIGVSNFS 160
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
21-312 |
1.49e-10 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 60.64 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 21 MNFGDVTDEKTSASILdEALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIVLATKVYQPmgpgp 99
Cdd:cd19134 16 LGVGELSDDEAERSVS-AALEAGYRLIDTAAAYGNEAA-------------VGRAIAASGiPRGELFVTTKLATP----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 100 nDRRLSAYhiRKACEDSLRRLKTDHIDVYQMH-HIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDIATaqsVATAR 178
Cdd:cd19134 77 -DQGFTAS--QAACRASLERLGLDYVDLYLIHwPAGREGKYVDSWGGLMKLREEGLARSIGVSNFTAEHLEN---LIDLT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 179 HFLGLVAEQSLYNLTARTiELEVIPAcrHFGLGLIPWSPlaggllggvlkkMASGRRA-RPAFARLIEQYrpqleayegl 257
Cdd:cd19134 151 FFTPAVNQIELHPLLNQA-ELRKVNA--QHGIVTQAYSP------------LGVGRLLdNPAVTAIAAAH---------- 205
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 488994162 258 cedlGETPSDVALAWLLQNPVVTAPliGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19134 206 ----GRTPAQVLLRWSLQLGNVVIS--RSSNPERIASNLDVFDFELTADHMDALD 254
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
9-163 |
1.63e-10 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 60.96 E-value: 1.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGT--MNFGDVTDektsasILDEALEAGINFIDTADVYGTEQspdiQQGSGLSEEiigrwLQQG-GRRERI 85
Cdd:cd19112 7 SGHKMPVIGLGVwrMEPGEIKE------LILNAIKIGYRHFDCAADYKNEK----EVGEALAEA-----FKTGlVKREDL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 86 VLATKVYQpmgpgpNDRRlsayHIRKACEDSLRRLKTDHIDVYQMHH-----------------------IDRHTPWEEI 142
Cdd:cd19112 72 FITTKLWN------SDHG----HVIEACKDSLKKLQLDYLDLYLVHFpvatkhtgvgttgsalgedgvldIDVTISLETT 141
|
170 180
....*....|....*....|.
gi 488994162 143 WQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19112 142 WHAMEKLVSAGLVRSIGISNY 162
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
10-312 |
1.93e-10 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 60.36 E-value: 1.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNfgdVTDEKTSASILDeALEAGINFIDTADVYGteqspdiqqgsglSEEIIGRWLQQGG-RRERIVLA 88
Cdd:cd19132 4 GTQIPAIGFGTYP---LKGDEGVEAVVA-ALQAGYRLLDTAFNYE-------------NEGAVGEAVRRSGvPREELFVT 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVyqpmgPGPNDRRLSAyhiRKACEDSLRRLKTDHIDVYQMH----HIDRHTpweEIWQAMELLVQQGKVLYIGSSNFa 164
Cdd:cd19132 67 TKL-----PGRHHGYEEA---LRTIEESLYRLGLDYVDLYLIHwpnpSRDLYV---EAWQALIEAREEGLVRSIGVSNF- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 165 gwdiataqsvaTARHFLGLVAEQSLY---NltarTIEL-------EVIPACRHFGLGLIPWSPLaggllggvlkkmasGR 234
Cdd:cd19132 135 -----------LPEHLDRLIDETGVTpavN----QIELhpyfpqaEQRAYHREHGIVTQSWSPL--------------GR 185
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488994162 235 RarpafARLIEQyrpqlEAYEGLCEDLGETPSDVALAWLLQNPVVtaPLIGPRTVEQLQQALHATTVTLSDDTMSCLD 312
Cdd:cd19132 186 G-----SGLLDE-----PVIKAIAEKHGKTPAQVVLRWHVQLGVV--PIPKSANPERQRENLAIFDFELSDEDMAAIA 251
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
10-282 |
3.44e-10 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 59.84 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNfgdVTDEKTSASILDEALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIVLA 88
Cdd:cd19156 6 GVEMPRLGLGVWR---VQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEG-------------VGQGIRESGvPREEVFVT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 89 TKVYQpmGPGPNDRRLSAYhirkacEDSLRRLKTDHIDVYQMHHiDRHTPWEEIWQAMELLVQQGKVLYIGSSNFAGWDI 168
Cdd:cd19156 70 TKLWN--SDQGYESTLAAF------EESLEKLGLDYVDLYLIHW-PVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 169 ATAQSVATARHFLGLVAEQSLynLTARTIEleviPACRHFGLGLIPWSPlaggllggvlkkMASGrrarpafaRLIEQyr 248
Cdd:cd19156 141 EELLKSCKVAPMVNQIELHPL--LTQEPLR----KFCKEKNIAVEAWSP------------LGQG--------KLLSN-- 192
|
250 260 270
....*....|....*....|....*....|....
gi 488994162 249 PQLEAyegLCEDLGETPSDVALAWLLQNPVVTAP 282
Cdd:cd19156 193 PVLKA---IGKKYGKSAAQVIIRWDIQHGIITIP 223
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
39-314 |
4.12e-10 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 59.78 E-value: 4.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQspdiQQGSGLSEEiigrwLQQGG-RRERIVLATKVYQpmgpgpNDRRlsAYHIRKACEDSL 117
Cdd:cd19129 28 ALEAGFRHFDCAERYRNEA----EVGEAMQEV-----FKAGKiRREDLFVTTKLWN------TNHR--PERVKPAFEASL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 118 RRLKTDHIDVYQMhhidrHTPWE-------------------------EIWQAMELLVQQGKVLYIGSSNFagwDIATAQ 172
Cdd:cd19129 91 KRLQLDYLDLYLI-----HTPFAfqpgdeqdprdangnviyddgvtllDTWRAMERLVDEGRCKAIGLSDV---SLEKLR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 173 SVA-TARHFLGLVAEQSLYNLTartiELEVIPACRHFGLGLIPWSPLaggllggvlkkmasGRRARPafaRLIEQyrPQL 251
Cdd:cd19129 163 EIFeAARIKPAVVQVESHPYLP----EWELLDFCKNHGIVLQAFAPL--------------GHGMEP---KLLED--PVI 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488994162 252 EAyegLCEDLGETPSDVALAWLLQNPvvTAPLIGPRTVEQLQQALHATtvTLSDDTMSCLDEI 314
Cdd:cd19129 220 TA---IARRVNKTPAQVLLAWAIQRG--TALLTTSKTPSRIRENFDIS--TLPEDAMREINEG 275
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
39-163 |
6.60e-10 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 59.35 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQspdiQQGSGLSEEIigrwLQQGGRRERIVLATKVYqpmgPGPNDRRLsayhIRKACEDSLR 118
Cdd:cd19107 26 AIDAGYRHIDCAYVYQNEN----EVGEAIQEKI----KEQVVKREDLFIVSKLW----CTFHEKGL----VKGACQKTLS 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488994162 119 RLKTDHIDVYQMHH-------------------IDRHTPWEEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19107 90 DLKLDYLDLYLIHWptgfkpgkelfpldesgnvIPSDTTFLDTWEAMEELVDEGLVKAIGVSNF 153
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
32-328 |
2.76e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 57.35 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 32 SASILDEALEAGINFIDTADVYGteqspdiqqgsgLSEEIIGRWLQ-QGGRRERIVLATKV-------YQPMGPGPNDRR 103
Cdd:cd19098 37 THAVLDAAWAAGVRYFDAARSYG------------RAEEFLGSWLRsRNIAPDAVFVGSKWgytytadWQVDAAVHEVKD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 104 LSAYHIRKACEDSLRRLKtDHIDVYQMHHIDRHTPWEEIWQAMELLVQQGKvlyigssnfAGWDI-----ATAQSVATAR 178
Cdd:cd19098 105 HSLARLLKQWEETRSLLG-KHLDLYQIHSATLESGVLEDADVLAALAELKA---------EGVKIglslsGPQQAETLRR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 179 HFLGLVAEQSLYNLTARTIEL------EVIPACRHFGLGLIpwsplaggllggVLKKMASGRRA----RPAFArlieqyr 248
Cdd:cd19098 175 ALEIEIDGARLFDSVQATWNLleqsagEALEEAHEAGMGVI------------VKEALANGRLTdrnpSPELA------- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 249 PQLEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGPRTVEQLQQALHATTVTLSDDTMSCLDEIwpgpgGEAPQAYaW 328
Cdd:cd19098 236 PLMAVLKAVADRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDVSLDLELLAALADL-----AEPPEDY-W 309
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
10-163 |
6.18e-09 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 55.69 E-value: 6.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 10 GLKVSRLCLGTMNFGDVTDEKTSAsildEALEAGINFIDTADVYGTEQspdiqqgsGLSEEIIGrwlqQGGRRERIVLAT 89
Cdd:cd19130 7 GNSIPQLGYGVFKVPPADTQRAVA----TALEVGYRHIDTAAIYGNEE--------GVGAAIAA----SGIPRDELFVTT 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488994162 90 KVYqpmgpgpNDRRlSAYHIRKACEDSLRRLKTDHIDVYQMHHidrHTP----WEEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19130 71 KLW-------NDRH-DGDEPAAAFAESLAKLGLDQVDLYLVHW---PTPaagnYVHTWEAMIELRAAGRTRSIGVSNF 137
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
28-165 |
8.14e-09 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 55.92 E-value: 8.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 28 DEKTSASILDEALEAGINFIDTADVYGTEQspdiQQGSGlseeiIGRWLQQG-GRRERIVLATKVYqpmgpgpndrrlSA 106
Cdd:cd19113 22 DNATAADQIYQAIKAGYRLFDGAEDYGNEK----EVGEG-----VNRAIDEGlVKREELFLTSKLW------------NN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 107 YH----IRKACEDSLRRLKTDHIDVYQMHH-------------------------IDRHTPWEEIWQAMELLVQQGKVLY 157
Cdd:cd19113 81 FHdpknVETALNKTLSDLKLDYVDLFLIHFpiafkfvpieekyppgfycgdgdnfVYEDVPILDTWKALEKLVDAGKIKS 160
|
....*...
gi 488994162 158 IGSSNFAG 165
Cdd:cd19113 161 IGVSNFPG 168
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
38-314 |
1.02e-08 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 55.49 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 38 EALEAGINFIDTADVYGTEQspdiQQGSGLSEeiiGRWLQQGGRRERIVLATKVYQpmgpgpNDRRLSayHIRKACEDSL 117
Cdd:cd19118 28 IALKAGYRHLDLAKVYQNQH----EVGQALKE---LLKEEPGVKREDLFITSKLWN------NSHRPE--YVEPALDDTL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 118 RRLKTDHIDVYQMH------------------------HIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFagwdiataqs 173
Cdd:cd19118 93 KELGLDYLDLYLIHwpvafkptgdlnpltavptnggevDLDLSVSLVDTWKAMVELKKTGKVKSIGVSNF---------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 174 vaTARHFLGLVAEQSL------YNLTARTIELEVIPACRHFGLGLIPWSPlaggllggvlkkMASGRRARPafaRLIEqy 247
Cdd:cd19118 163 --SIDHLQAIIEETGVvpavnqIEAHPLLLQDELVDYCKSKNIHITAYSP------------LGNNLAGLP---LLVQ-- 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488994162 248 RPQLEAyegLCEDLGETPSDVALAWLLQNPVVTAP--LIGPRTVEQLQQalhattVTLSDDTMSCLDEI 314
Cdd:cd19118 224 HPEVKA---IAAKLGKTPAQVLIAWGIQRGHSVIPksVTPSRIRSNFEQ------VELSDDEFNAVTAL 283
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
24-163 |
1.32e-08 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 55.35 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 24 GDVTDEktsasiLDEALEAGINFIDTADVYGTEQspdiQQGSGLSEEIigrwlQQGG-RRERIVLATKVYQPMgpgpNDR 102
Cdd:cd19110 17 GEVTEA------VKVAIDAGYRHFDCAYLYHNES----EVGAGIREKI-----KEGVvRREDLFIVSKLWCTC----HKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 103 RLsayhIRKACEDSLRRLKTDHIDVYQMH------------HIDR-------HTPWEEIWQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19110 78 SL----VKTACTRSLKALKLNYLDLYLIHwpmgfkpgepdlPLDRsgmvipsDTDFLDTWEAMEDLVIEGLVKNIGVSNF 153
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
9-176 |
5.10e-08 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 53.43 E-value: 5.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNFGdVTDEKTSASILdEALEAGINFIDTADVYGTEQSpdiqQGSGLSEEIigrwlQQG--GRRERIV 86
Cdd:cd19124 1 SGQTMPVIGMGTASDP-PSPEDIKAAVL-EAIEVGYRHFDTAAAYGTEEA----LGEALAEAL-----RLGlvKSRDELF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 87 LATKVYqpMGPGPNDRRLSAyhIRKacedSLRRLKTDHIDVYQMHHIDRHTP----------------WEEIWQAMELLV 150
Cdd:cd19124 70 VTSKLW--CSDAHPDLVLPA--LKK----SLRNLQLEYVDLYLIHWPVSLKPgkfsfpieeedflpfdIKGVWEAMEECQ 141
|
170 180
....*....|....*....|....*.
gi 488994162 151 QQGKVLYIGSSNFAGWDIATAQSVAT 176
Cdd:cd19124 142 RLGLTKAIGVSNFSCKKLQELLSFAT 167
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|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
38-314 |
7.72e-08 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 52.95 E-value: 7.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 38 EALEAGINFIDTADVYGTEQspdiQQGSGlseeiIGRWLQQG-GRRERIVLATKVYQPMGpgpndrrlSAYHIRKACEDS 116
Cdd:cd19114 25 NAIKVGYRLIDGALLYGNEA----EVGRG-----IRKAIQEGlVKREDLFIVTKLWNNFH--------GKDHVREAFDRQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 117 LRRLKTDHIDVYQMH------HID--------------RHTPWE-----EIWQAMELLVQQGKVLYIGSSNF---AGWDI 168
Cdd:cd19114 88 LKDYGLDYIDLYLIHfpipaaYVDpaenypflwkdkelKKFPLEqspmqECWREMEKLVDAGLVRNIGIANFnvqLILDL 167
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 169 ATAQSVATArhflglVAEQSLYNLTARTielEVIPACRHFGLGLIPWSPLAGGLLGGVLKKMASgrrarpaFARLIEQyr 248
Cdd:cd19114 168 LTYAKIKPA------VLQIEHHPYLQQK---RLIDWAKKQGIQITAYSSFGNAVYTKVTKHLKH-------FTNLLEH-- 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488994162 249 pqlEAYEGLCEDLGETPSDVALAWLLQNPVVTAPLIGprTVEQLQQALHATTVTLSDDTMSCLDEI 314
Cdd:cd19114 230 ---PVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSV--NVERMKTNLDITSYKLDEEDMEALYEL 290
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|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
39-163 |
1.01e-06 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 49.54 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQspdiQQGSGLSEEIigrwlqQGG--RRERIVLATKVYqpmgpgpndrrlSAYH----IRKA 112
Cdd:cd19108 36 AIDAGFRHIDSAYLYQNEE----EVGQAIRSKI------ADGtvKREDIFYTSKLW------------CTFHrpelVRPA 93
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 113 CEDSLRRLKTDHIDVYQMHHIDRHTPWEEI-------------------WQAMELLVQQGKVLYIGSSNF 163
Cdd:cd19108 94 LEKSLKKLQLDYVDLYLIHFPVALKPGEELfpkdengklifdtvdlcatWEAMEKCKDAGLAKSIGVSNF 163
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|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
39-308 |
3.04e-06 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 47.71 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 39 ALEAGINFIDTADVYGTEQSpdiqqgsglseeiIGRWLQQGG-RRERIVLATKVYQpmgpgpndRRLSAYHIRKACEDSL 117
Cdd:PRK11172 25 ALELGYRAIDTAQIYDNEAA-------------VGQAIAESGvPRDELFITTKIWI--------DNLAKDKLIPSLKESL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 118 RRLKTDHIDVYQMH--HIDRHTPWEEIWQAMELLVQQGKVLYIGSSNFagwDIA-TAQSVATarhfLGlvAEqslyNLTA 194
Cdd:PRK11172 84 QKLRTDYVDLTLIHwpSPNDEVSVEEFMQALLEAKKQGLTREIGISNF---TIAlMKQAIAA----VG--AE----NIAT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 195 RTIEL-------EVIPACRHFGLGLIPWSPlaggllggvlkkMASGRR-ARPAFARLIEQYrpqleayeglcedlGETPS 266
Cdd:PRK11172 151 NQIELspylqnrKVVAFAKEHGIHVTSYMT------------LAYGKVlKDPVIARIAAKH--------------NATPA 204
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 488994162 267 DVALAWLLQNPVVTAPLIGPRtvEQLQQALHATTVTLSDDTM 308
Cdd:PRK11172 205 QVILAWAMQLGYSVIPSSTKR--ENLASNLLAQDLQLDAEDM 244
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
9-164 |
1.14e-05 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 46.34 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 9 TGLKVSRLCLGTMNfgDVTDEKTSASILDEALEAGINFIDTADVYGTEqsPDIQQGsglseeiIGRWLQQGG-RRERIVL 87
Cdd:cd19119 8 TGASIPALGLGTAS--PHEDRAEVKEAVEAAIKEGYRHIDTAYAYETE--DFVGEA-------IKRAIDDGSiKREELFI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 88 ATKVYqpmgPGPNDrrlsayHIRKACEDSLRRLKTDHIDVYQMHH------IDRHTP-------------------WEEI 142
Cdd:cd19119 77 TTKVW----PTFYD------EVERSLDESLKALGLDYVDLLLVHWpvcfekDSDDSGkpftpvnddgktryaasgdHITT 146
|
170 180
....*....|....*....|..
gi 488994162 143 WQAMELLVQQGKVLYIGSSNFA 164
Cdd:cd19119 147 YKQLEKIYLDGRAKAIGVSNYS 168
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
16-163 |
3.76e-05 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 44.79 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 16 LCLGTMNFGDVTDEKTSASILDEALEAGINFIDTADVYGTEQspdiQQGSGLSEEIIGRWLqqggRRERIVLATKVYQPM 95
Cdd:cd19109 7 IGLGTYSEPKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEH----EVGQAIREKIAEGKV----KREDIFYCGKLWNTC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488994162 96 GPgpndrrlsAYHIRKACEDSLRRLKTDHIDVYQMHHIDRHTPWEEI-------------------WQAMELLVQQGKVL 156
Cdd:cd19109 79 HP--------PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIyprdengkwlyhktnlcatWEALEACKDAGLVK 150
|
....*..
gi 488994162 157 YIGSSNF 163
Cdd:cd19109 151 SIGVSNF 157
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