|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
2-849 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 1528.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 2 GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADStatkgakkpkkdersALVNRMGVDPWHDWNA 81
Cdd:PRK07561 1 GKSLVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSASSVPAKEKG---------------ALWARMGVDPDHDFEA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDR 161
Cdd:PRK07561 66 LYEVLPGKEKVVSELKKAAKDADELYLATDPDREGEAIAWHLLEVLGGDDVPVKRVVFNEITKNAIQEAFENPRELDINL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 162 VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHK 241
Cdd:PRK07561 146 VNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDAFEARLTHL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 242 DDKPFRPV---SRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHIT 318
Cdd:PRK07561 226 DGKKFAPVdllNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYIT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 319 YMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASK-ENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQLIWRQ 397
Cdd:PRK07561 306 YMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSKaKNAQEAHEAIRPSDVFRTPDQLKGLEGDAQRLYELIWKR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 398 FVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKG---DEDRTLPLVKQGDRLSLVELTPAQHFTKPP 474
Cdd:PRK07561 386 FVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDaldDEDRRLPALKVGDALTLEKLDPTQHFTKPP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVA 554
Cdd:PRK07561 466 ARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 555 NHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALppKERCKTTI 634
Cdd:PRK07561 546 NGEADWKPVLDDFYKDFSQQLEKAEELREEGGMRPNQMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYAL--KERCKTTR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 635 NLVPENEVLNVLEGDDAETNALRAKrrcQKCGTAM-------DSYLI----DPKRKLHVC-GNNPTCDGYEIEEGEFRIK 702
Cdd:PRK07561 624 NLTPEEETLNVLEGEDAETRALGAD---PECGTAMvlrsgrfGPYVQegegDKPRRLSLPkGNNPECVGLEIALGLLSLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 703 gydGPVVECEKCGSEMHLKMGRFGKYMAC--TNDECKNTRKILRNGEVAP---------PKEDPVPLPELPCEKSDAYFV 771
Cdd:PRK07561 701 ---RPVGEHPECGSEIQAKIGRFGPYVKCggTYASLKNTRKVLTIGLNRAvellaepkrPKEDPVPLPELGCPKSGAPFV 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 772 LRDGAAGVFL----AANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGK 847
Cdd:PRK07561 778 LRDGRYGPYVkhgkANATLPKGRETRAPTVEEALELLAEKPEKLRYLADAPAKDPAGKKAAVKFSRKTKQQYVASEKDGK 857
|
..
gi 488991000 848 AT 849
Cdd:PRK07561 858 AT 859
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-637 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 914.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 5 LVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSgsaskksadstatkgakkpkkdersalvnRMGVDPWHDWNAHYE 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKS-----------------------------RLGVDIEKDFEPEYV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 85 VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNA 164
Cdd:TIGR01051 52 VSKGKKKVVKELKTLAKKADEVYLATDPDREGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTpGGDALPLQVTHKDDK 244
Cdd:TIGR01051 132 QQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVPEEYWTIDATFQK-GEETFEALLTEVNGK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 245 PFRPVSRD---ETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------- 314
Cdd:TIGR01051 211 KLKAGSDLdeaEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGvstgdgt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 315 -GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKE-NSQEAHEAIRPSDVNVLAETLKD-MEADAQKLY 391
Cdd:TIGR01051 291 iGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKEkNAQEAHEAIRPTSVFRTPEELKDyLKRDEFRLY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 392 QLIWRQFVACQMTPAQYDSTTLTVAA--GDFKLKARGRTLRFDGWTKVMPALRKG---DEDRTLPLVKQGDRLSLVELTP 466
Cdd:TIGR01051 371 ELIWKRFVASQMADARYDSTSVRLTNedGEYVFKATGRKLIFDGYYKVYVEGSDDpleEKDRILPPLKEGDAVKLVEVKP 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQM 546
Cdd:TIGR01051 451 NQHFTQPPARYTEASLVKELEELGIGRPSTYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKM 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 547 EDRLDQVANHQAEWKEVLNHFFGDFTTQLataekdPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalpp 626
Cdd:TIGR01051 531 EKDLDEIAEGKAEWKPVLKNFYTGFSSKV------KKLRNMRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNF---- 600
|
650
....*....|.
gi 488991000 627 kERCKTTINLV 637
Cdd:TIGR01051 601 -PECKYTKSIV 610
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-742 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 879.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPtsgsaskksadstATKGakkpkkdersalvnrmGVDPWHDWN 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLP-------------KKKG----------------GVDPDNDFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG---GDEQRYSRVVFNEITKNAIRQAFEKPGEL 157
Cdd:PRK06599 52 PKYEIIEGKEKVVDALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeakLKDKNVKRVVFNEITKKAVQEAIENPRDI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQ 237
Cdd:PRK06599 132 DMDLVDAQQARRALDYLVGFKLSPLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEPFTAK 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 238 VTHKDDK---PFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314
Cdd:PRK06599 212 LVEVNGKkleKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 315 --------GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASK-ENSQEAHEAIRPSDVNVLAETLKD-ME 384
Cdd:PRK06599 292 idlgegtvGLITYMRTDSVRLSNEALDEARKYITKKYGKEYLPAKPRVYKKKsKNAQEAHEAIRPTSINRTPESLKPyLT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 385 ADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAA--GDFKLKARGRTLRFDGWTKVMPA---LRKGDEDRTLPLVKQGDRL 459
Cdd:PRK06599 372 PDQFKLYELIWKRTVASQMAPAILDQTSVDIASenGKYVFRATGSVILFPGFLKVYGEskdDEEEDDEKLLPPLKEGEKL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 460 SLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMN 539
Cdd:PRK06599 452 KLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVD 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 540 YDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEggmQPNPMVLTSIDCPTC-GRKMGIRTASTGVFLG 618
Cdd:PRK06599 532 YDFTAGLEDELDEIAEGKKDWKPVLREFWEPFISNLEKVEEDVRT---EKVTQEETDETCPKCgGGPLVLKLGKNGKFLG 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 619 CSGYalpPKerCKTTINLVPENEVlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnptcdgyEIEEGE 698
Cdd:PRK06599 609 CSGY---PE--CKYTKNITRDEDE--------------------------------------------------PIEEEE 633
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 488991000 699 FRikgydgPVVECEKCGSEMHLKMGRFGKYMACTND-ECKNTRKI 742
Cdd:PRK06599 634 IV------EEEKCPKCGGPLVLKKGRYGKFLACSGYpECKHIKPL 672
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
3-576 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 859.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadstatkgakkpkkdersalvnrMGVDPWHDWNAH 82
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPE-----------------------------LDVDVENDFEPK 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRV 162
Cdd:COG0550 52 YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG-DKKPVKRVVFNEITKKAIKEAFKNPRDIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGdalPLQVTHKD 242
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGG---EFTAKLVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 243 DKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRT 322
Cdd:COG0550 208 IDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 323 DSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQEAHEAIRPSDVNVlaeTLKDMEADAQKLYQLIWRQFVACQ 402
Cdd:COG0550 288 DSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTR---TPESLSGDEFKLYDLIWKRFLASQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 403 MTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALR---KGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSE 479
Cdd:COG0550 365 MPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTE 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAE 559
Cdd:COG0550 445 ASLVKAMEELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLD 524
|
570
....*....|....*..
gi 488991000 560 WKEVLNHFFGDFTTQLA 576
Cdd:COG0550 525 WKDVLEEFYKPFKELVE 541
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-763 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 596.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadstatkgakkpkkdersalvnrMGVDPWHDWN 80
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKE-----------------------------FGIDIENDFE 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEQRYSRVVFNEITKNAIRQAFEKPGELNID 160
Cdd:PRK06319 52 PDYQILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLP-KNTKIQRISFNAITKGAVTEALKHPREIDMA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPggdalplqv 238
Cdd:PRK06319 131 LVNAQQARRLLDRIVGYKISPILSRKLQRrsGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDP--------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 239 thKDDKPFRPV--------------------------SRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQA 292
Cdd:PRK06319 202 --KTQKTFWAHlysvdgkkwekeipegktedevllinSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 293 ASTRLGFGVKKTMMMAQRLYEA---------GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQE 363
Cdd:PRK06319 280 ASRHFRFSSSRTMNIAQTLYEGvdldsegatGLITYMRTDSVRTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQD 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 364 AHEAIRPSDVNVLAETLKDMEADAQ-KLYQLIWRQFVACQMTPAQYDSTTLTVAAG-DFKLKARGRTLRFDGWTKVMPAL 441
Cdd:PRK06319 360 AHEAIRPTDITLTPEKLRSKLTEDQyKLYSLIWKRFVASQMIPAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVYEEK 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 442 R----KGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517
Cdd:PRK06319 440 RddegDEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRL 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 518 YAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEggmqpnPMVLTSI 597
Cdd:PRK06319 520 RPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAFI------PRIVTEI 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 598 DCPTC-GRKMGIRTASTGVFLGCSGYalppkerckttinlvpenevlnvlegddaetnalrakrrcqkcgtamdsylidp 676
Cdd:PRK06319 594 DCPKChKGKLVKIWAKNRYFYGCSEY------------------------------------------------------ 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 677 krklhvcgnnPTCDgYEIEEGE--FRIKGY------DGPvveCEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGE 747
Cdd:PRK06319 620 ----------PECD-YKTSEEEltFNKEDYaedtpwDSP---CPLCGGEMKVRHGRFGTFLGCENyPECRGIINIHKKGE 685
|
810
....*....|....*.
gi 488991000 748 VAPPKEDPVPLPELPC 763
Cdd:PRK06319 686 EGIEPEETVPCPAIGC 701
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-571 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 570.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDL-PTSGSaskksadstatkgakkpkkdersalvnrmgVDPWHDW 79
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDLvPKEGA------------------------------VDPENGF 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 80 NAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG----DEQRYSRVVFNEITKNAIRQAFEKPG 155
Cdd:PRK08780 51 AMRYDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKErgllKDKPMQRVVFTEITPRAIKEAMAKPR 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGgDALP 235
Cdd:PRK08780 131 DIASDLVDAQQARRALDYLVGFNLSPLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPS-QPFN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 236 LQVTHKDDKPFRP---VSRDETMAAVSLLEKASYSVL---EREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQ 309
Cdd:PRK08780 210 AKLIKLDGQKFEQftiTDGDTAEAARLRIQQAAQGTLhvtDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 310 RLYEA---------GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASK-ENSQEAHEAIRPSDVNVLAET 379
Cdd:PRK08780 290 KLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKsKNAQEAHEAVRPTSALRTPAQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 380 LKD-MEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGD-FKLKARGRTLRFDGWTKVMPALR------KGDEDRTLP 451
Cdd:PRK08780 370 VARfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSeHVFRATGSTVVVPGFLAVYEEGKddksaeDEDEGRKLP 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 452 LVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531
Cdd:PRK08780 450 PMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLT 529
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 488991000 532 ENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDF 571
Cdd:PRK08780 530 GHFTRYVDYDFTARLEDDLDAVSRGEKEWIPLMEKFWGPF 569
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
159-571 |
2.71e-168 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 492.89 E-value: 2.71e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 159 IDRVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTttpggdalpl 236
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKEAV---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 237 qvthkddkpfrpvsrdetmaavsllekasysVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGH 316
Cdd:cd00186 71 -------------------------------VVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 317 ITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQ----YASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQ 392
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLgrrnPKRGKKEQGAHEAIRPTKVAPTPELEANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 393 LIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDrTLPLVKQGDRLSLVELTPAQHFTK 472
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEE-EPPPLKEGDELKLEEVELEEKETQ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQ 552
Cdd:cd00186 279 PPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410
....*....|....*....
gi 488991000 553 VANHQAEWKEVLNHFFGDF 571
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEF 377
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-565 |
1.37e-157 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 466.72 E-value: 1.37e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDA 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 234 LPLQvthkdDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313
Cdd:pfam01131 81 ANAK-----WKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 314 -AGHITYMRTDSTNLSQDA-LNMVRGYISDKFGKkYLPDSANQYASK------ENSQ-EAHEAIRPSDVNVLAETLKDme 384
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGK-YLPYAPRLLKKTkgkltvGNAKvTAHEAIRPTGDIPVLPELSD-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 385 aDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKgDEDRTLPLVKQGDRLSLVEL 464
Cdd:pfam01131 233 -DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK-EDEEELPELKEGEELKVTQV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLeENFRDLMNYDFTA 544
Cdd:pfam01131 311 EVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEAL-EKFPDLVDPELTA 389
|
410 420
....*....|....*....|.
gi 488991000 545 QMEDRLDQVANHQAEWKEVLN 565
Cdd:pfam01131 390 ELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-526 |
4.17e-115 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 351.16 E-value: 4.17e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 272 EDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDS 351
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 352 A-----NQYASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARG 426
Cdd:smart00437 81 VvllkpRKPRKGKKAQGAHEAIRPTKPIFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 427 RTLRFDGWTKVMPALRKgDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK-EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|
gi 488991000 507 RGYVRVENRRFYAEKMGEIV 526
Cdd:smart00437 240 RGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
87-793 |
4.22e-98 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 324.65 E-value: 4.22e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAI---AWHLREVIGGDEQRysRVVFNEITKNAIRQAFEKPGELNIDRVN 163
Cdd:PRK07219 82 ITKQNYINALKKLAKDADEIIIATDYDREGELIgkeAYHILREVCQVPVK--RARFSSLTKKEIRKAFENPDEIDFNLAD 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 164 AQQARRFMDRVVGYMVSPLLW---KKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDAS-TTTPGGDALPLQ 237
Cdd:PRK07219 160 AGEARQIIDLYWGAALTRFLSlsvRQLGRWdfLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALlDKEAQYFYRDLI 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 238 VTHKDDKPFrpvSRDETMAAVSLLEKASYS-VLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGH 316
Cdd:PRK07219 240 GGHEAEKFW---DEEEAEEIYEKLKGAKEAtVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGY 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 317 ITYMRTDSTNLSQD-ALNMVRGYISDKfgKKYLPD-----SANQYASKENSQE--AHEAIRPSDVnvlaETLKDMEADAQ 388
Cdd:PRK07219 317 ISYPRTDNTVYPDDlDPKELLKKLSKK--KEYGPYaesilEQENIKPTEGKKEttDHPPIHPVDV----PKREELSDDEW 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 389 KLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLPLVKQGDRLSLVELTPAQ 468
Cdd:PRK07219 391 KVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKF--DEKELPDLEEGEKLKVNKIEIEA 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMED 548
Cdd:PRK07219 469 KETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEA 547
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 549 RLDQVANHQA-------EWKEVLNHFFGDFTTQlaTAE-KDPEEGGMQPNPMVLTSI-DCPTCGRKMGIRTASTGV-FLG 618
Cdd:PRK07219 548 DMQAIEDGKKkkedvteESREMLKEILSELKEK--RKEiGDHLAGSLKAENRSLKTIgKCPECGGDLIIIRTDKGSrFVG 625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 619 CSGYalppkERCKTTINLvPENEVLNVLEgddaetnalrakRRCQKCGTAMDSYLIDPKRKLHVCgnnPTCDGYEIEEGE 698
Cdd:PRK07219 626 CSGY-----PDCRNTFPL-PSTGRIKVLD------------EVCEKCGLPVIKILRGKQTFVVGC---PDCEAEKEEEDP 684
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 699 FRIKGydgpvvECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDpvplpelpCEKSDAYFVLRDGAA 777
Cdd:PRK07219 685 DEVIG------PCPKCGGELAIKQLKYGSFLGCTNyPKCKYTLPLPRRGKITVTDEK--------CPECGLPLLRVKGGF 750
|
730
....*....|....*.
gi 488991000 778 GVFLAANTFPKSRETR 793
Cdd:PRK07219 751 GDELGCCNNPKCNYTE 766
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
4-568 |
3.76e-89 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 307.67 E-value: 3.76e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 4 ALVIVESPAKAKTINKYLGN-----------------DYV--VKSSVGHIRDLPTSGSAS-------------------K 45
Cdd:COG1110 631 ALVIVESPNKARTIASFFGKpsrrrigglrvyevsigDYLllITASGGHVFDLVTEAYARgfygvlvengrfipvydtiK 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 46 KSAD--STATKGAKKPKKDERSALVNrmgvdpwhdwnahyevlpgKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123
Cdd:COG1110 711 RCLDcgEQFTDEVEVCPRCGSPNIVD-------------------SLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDV 771
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 124 REVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVR 202
Cdd:COG1110 772 YNLLRPYAKNIKRIEFHEVTRKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLG 851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 203 LVVEREREikaFVPEEYWEVdaSTTTPGGdalPLQVTHKDDKPFRPVSRdetmaAVSLLEKASYSVLEREDKPTSSKPga 282
Cdd:COG1110 852 WIIERYEE---SRKSKKYLI--ILTLENG---RLELSIEDLKEAEEVRK-----ALEKEVKVKVKKVEEEEEELNPLP-- 916
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLpdsanqYASKENSQ 362
Cdd:COG1110 917 PYTTDTLLRDASRRLGLSAEETMRLAQDLFESGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYF------KPRRWGEG 990
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 363 EAHEAIRPS---DVNVL--------AETLKDMEADAQKLYQLIWRQFVACQMTPA--QYDSTTLTVAAGDFKLKARGRT- 428
Cdd:COG1110 991 GAHEAIRPTrplDAEDLrrlieegvIELPIPLTRRHLRLYDLIFRRFMASQMRPAkvEKVKLRVSLELPGGEIEEERIVe 1070
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 429 LRFDGWTKVMPALRKGDEdrtlplVKQGDrlslVELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQDR 507
Cdd:COG1110 1071 IIEDGFLLIYPPIKVEPE------LKEGE----YKVTEVKIRKVPKVPlYTQGDLVREMKERGIGRPSTYAKIVETLLRR 1140
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488991000 508 GYVRVENRR--FYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFF 568
Cdd:COG1110 1141 GYVVESKKGkkLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
4-564 |
4.55e-83 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 289.81 E-value: 4.55e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSGS---------------ASKKSAD 49
Cdd:TIGR01054 603 ALLVVESPNKARTIARFFGkpsvrkiggsvvyevpvGDLIlmITASGGHVFDLVTDKGfhgvlvengryvpvyTSIKRCR 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 50 STATKGAKKPKKDERSALVNRMGvdpwhdwnahyevlpgKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG 129
Cdd:TIGR01054 683 DCGYQFTEDRESCPKCGSENIED----------------SKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLSP 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 130 DEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVERE 208
Cdd:TIGR01054 747 YNPNVKRAEFHEVTRRAILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFNkRWLSAGRVQTPVLGWIIDRY 826
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 209 REIKAFVPEEYWEVDAStttpggdALPLQVTHKDDKPFRPVSRDETMAAVSLLEkasysvlEREDKPTsskPGAPFITST 288
Cdd:TIGR01054 827 RESREKRGYLLIFALES-------DFRLGLEHDNRLEAKEFEKDLTWLDVEDIA-------EREEERN---PLPPYTTDT 889
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 289 LQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYlpdsanQYASKENSQEAHEAI 368
Cdd:TIGR01054 890 MLEDANRKLGLSVKETMQIAQELFENGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEY------FYPREWGEGGAHECI 963
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 369 RPS---DVNVLAETLK-------DMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLR-FDGWTKV 437
Cdd:TIGR01054 964 RPTrplDVDDLQRLILegvieleGLTREHLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKEAEEEGIVEIvERGFELV 1043
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 438 MPALRKGDEDRTLPLVKQGDRLSLVELTPAqhftkpparFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517
Cdd:TIGR01054 1044 YPLWRKNELEKGSTFIVKDKELRSVPKVYP---------YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKGFL 1114
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 488991000 518 YAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVL 564
Cdd:TIGR01054 1115 IPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVL 1161
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
83-622 |
6.43e-79 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 268.57 E-value: 6.43e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAwhlREVIggdeqRYSRVV-------FNEITKNAIRQAFE--K 153
Cdd:PRK07726 73 LVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIA---REIL-----DYCGVRkpikrlwISSLTDKAIKRAFAnlK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTt 228
Cdd:PRK07726 145 PGKETIPLYYSALARSRADWLVGINMTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT- 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 229 pGGDALPLQVTHKD---DKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTM 305
Cdd:PRK07726 224 -PGERFTAKWQPSEpyqDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 306 MMAQRLYE-AGHITYMRTDSTNLSQD----------ALNMVRGYisdkfgKKYLPDSANqyaSKENSQ-------EAHEA 367
Cdd:PRK07726 303 DIAQSLYEtHKLITYPRTDSRYLPEDmvatlpevlnAISKVDPY------LLLAPPVLD---PSIRSRawndkkvTAHHA 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 368 IRPSDVNVLAETLKDMEadaQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDE- 446
Cdd:PRK07726 374 IIPTEQPPNLSKLSEDE---RKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEk 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 447 DRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLV------------KELEKR-----GIGRPSTYASIISTIQDRGY 509
Cdd:PRK07726 451 EQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLsameniarfvqdKELKKTlketdGLGTEATRAGIIEKLFKRGY 530
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 510 VRVENRRFYAEKMGEIVTDRLEEnfrDLMNYDFTAQMEDRLDQVANHQAEwkevLNHFFGD---FTTQLAtaekdpEEGG 586
Cdd:PRK07726 531 LEKKGKYIHATDKGKQLIDALPE---ELTSPDMTAKWEQALDQISEGQLS----YQDFMQPlkqWLKQLV------EQAK 597
|
570 580 590
....*....|....*....|....*....|....*....
gi 488991000 587 MQPNPMVLTSID---CPTCGRKMGIRTASTGVFLGCSGY 622
Cdd:PRK07726 598 QSSEKYKFDNLTgpkCPDCGKPMLKVKGKNGKMLVCQDR 636
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
7-622 |
4.06e-75 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 257.45 E-value: 4.06e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 7 IVESPAKAKTINKYLGNDYVVKSSVG------HIRDlptsgsaSKKSADSTATKGAKKPKKDERsalvnrmGVDPWHD-- 78
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKKSEYgvpyweVRRD-------GKKIIVASAVGHLFGLHPKSR-------GGYPVFDie 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 79 WNAHYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREViGGDEQRYSRVVFNEITKNAIRQAFEKPG 155
Cdd:TIGR01057 67 WVPIFEFDKGKGyvsKYIKALSKLAKGADEYINACDYDIEGEVIGFKALKY-FCGVERAKRMKFSTLTKQDIRRAYANPE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTP 229
Cdd:TIGR01057 146 EIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 230 GGdalPLQVTHKDDKPFrpvSRDETMAAVSLLEKA-SYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMA 308
Cdd:TIGR01057 226 GG---VFDARPEKWKIW---SEEEAKSIKEELKKSpWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 309 QRLYEAGHITYMRTDSTNLSQDalnmvRGY--ISDKFGK-----------KYLPDSANQYASKENsqEAHEAIRPSDVNV 375
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPS-----INYraILDNLAKgplyreaaerlLETGVLKPVEGKKED--PAHPAIHPTGEIP 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 376 LAETLKDMEadaqKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEdrTLPLVKQ 455
Cdd:TIGR01057 373 SQELSKDEK----KVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEK--ELPPLDR 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 456 GDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEENFR 535
Cdd:TIGR01057 447 GDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYI-EGKKSIKVTPLGEAVIETLQRYCP 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 536 DLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGMQPNPMVLTS---IDCPTCGRKMGIRTAS 612
Cdd:TIGR01057 526 EIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRLDDIGIELGKSLGSVevvGKCPKCGGKLVSKYAK 605
|
650
....*....|
gi 488991000 613 TGVFLGCSGY 622
Cdd:TIGR01057 606 KGRFVGCSNY 615
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-605 |
4.91e-69 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 241.82 E-value: 4.91e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 2 GKALVIVESPAKAKTIN--------------------KYLGNDYVVKSSVGHIRDLptsgsaskksadstATKGAKKPKK 61
Cdd:PRK05776 1 GYILVIAEKPKAARKIAealsekpircriygvpywivKRDGKKIVVAPAAGHLFGL--------------HTKSKGFPVF 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 62 DersalvnrmgvdpwHDWNAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEQRYSRVV 138
Cdd:PRK05776 67 D--------------YEWKPLYEIDKGSkytKKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLG-DPKKAKRMK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 139 FNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK--KIARG----LSAGRVQSVAVRLVVEREREIK 212
Cdd:PRK05776 132 FSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSsvRDASGkrviLSAGRVQSPTLKYVVEREIERN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 213 AFVPEEYWEVDAsTTTPGGDALPLQVThkdDKPFRpvSRDETMAAVSLLEKASY-SVLEREDKPTSSKPGAPFITSTLQQ 291
Cdd:PRK05776 212 LFVPLPYFSVSI-IIEKNGYEFTLKYE---NKKFE--TKEEAKEILEEIKKTGYlKVTKVEVKIEILEPPPPFNLGDLQV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 292 AASTRLGFGVKKTMMMAQRLYEAGHITYMRTDS-------------TNLSQ---------DALNMVRGYISDKFGKKYLP 349
Cdd:PRK05776 286 EAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSqklpptlnirnilKGLSRspqyrplvnLLLKETKGVLKPVQGPKDDP 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 350 dsanqyaskensqeAHEAIRPSdvnvlAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDF--KLKARGR 427
Cdd:PRK05776 366 --------------AHPAIYPT-----GEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQ 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 428 TLRFDGWTKVMPaLRKGDEDrTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507
Cdd:PRK05776 427 RIEERGWLKYYP-FHKFDEE-ELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKR 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 508 GYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQA-------EWKEVLNHFFGDFTTQLATA-E 579
Cdd:PRK05776 505 GYLTSNGKYIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGKAtreevieEAKETLNKLLEEFKKNKDEIgE 584
|
650 660
....*....|....*....|....*.
gi 488991000 580 KDPEEGGMQPNPMvltsiDCPTCGRK 605
Cdd:PRK05776 585 ELAKALGLIKPVG-----KCKICGRE 605
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
3-622 |
2.29e-67 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 237.05 E-value: 2.29e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYL------------GNDYVVKSSVGHIRDLptsgsaskksadstatkgaKKPKK-DERSALVN 69
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLakkkkgngyleiGVGGFVTWAVGHLVEL-------------------AEPEEyDEKYKNWR 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 70 RMGV----DPWHdwnahYEVLPGKEKVVSELKQL--AEKADHIYLATDLDREGEAIA-WHLREVIGGDEQRYSRVVFNEI 142
Cdd:TIGR01056 62 TYDLplepEDWQ-----LVVSDKTKKQFNVIKRIlkENKVDEVVIATDPDREGELIArEILDYLKVTDKVTIKRLWISSL 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 143 TKNAIRQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFV 215
Cdd:TIGR01056 137 VDSSIRKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLgreagNDGVLSVGRVQTPTLAMVVKRENEIKNFV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 216 PEEYWEVDASTTTPgGDALPLQVTHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAAST 295
Cdd:TIGR01056 217 GKPFYEVSATINKD-EQEFTTEWQPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 296 RLGFGVKKTMMMAQRLYEAGH-ITYMRTDSTNLSQDALNMVRGYISDKFGKKYL--------PDSANQYASkENSQEAHE 366
Cdd:TIGR01056 296 RFGISAKRTLDIAQKLYETHKlITYPRTDSRYLPEDEKEMLLEVLDALKVITPAllpikkrdELTNNRLWN-DKKIEDHH 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 367 AIRPSDVNVLAETLKDMEAdaqKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDE 446
Cdd:TIGR01056 375 AIIPTGNDFNLSDLSEEER---NVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEE 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 447 --DRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDR 507
Cdd:TIGR01056 452 teDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMtnpaafvqdkglkktlkETKGLGTEATRADIIENLFKR 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 508 GYVRVENRRFYAEKMGEIVTDRLEEnfrDLMNYDFTAQMEDRLDQVANHQAEWKEVLNhffgdftTQLATAEKDPEEGGM 587
Cdd:TIGR01056 532 GFIQKKKNKIYITKNGKLLCLLLPE---LLTKPDLTAQWEQYLNGISAGEKDDDDFIN-------TINEMIKQTINEEKK 601
|
650 660 670
....*....|....*....|....*....|....*
gi 488991000 588 QPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622
Cdd:TIGR01056 602 NPETIQKVAKEPVSCGGIAKCPAKDNGRLIDCKKF 636
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
73-666 |
2.18e-66 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 236.19 E-value: 2.18e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 73 VDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQ--RYSRVVFNEITKNAIRQA 150
Cdd:PRK07220 68 VDARDLIDAEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKVNPdiKFDRVRYSAITKKEIERA 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 151 FEKPGELNIDRVNAQQARRFMDRVVGYMVSPllWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDA 224
Cdd:PRK07220 148 FSNPVEVDFNLADAGHSRQVIDLVWGAALTR--YISLAAGrlgkmfLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYA 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 225 STTTPGGdalPLQVTHKDDkpfRPVSRDETMAAVSLLEKASySVLEREDKPTSSKPGAPFITSTLQQAASTrLGFGVKKT 304
Cdd:PRK07220 226 TLENNGE---TFVAQHSTR---RFWEKEEADRVFEKLGKTA-EVTEVEKGTKTDKPPTPFNTTEFISAANS-IGFSAANA 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 305 MMMAQRLYEAGHITYMRTDSTNL--SQDALNMVRGYISDKFGK--KYLPDSANQYASKENSQEA-HEAIRPSDVNVLAEt 379
Cdd:PRK07220 298 MRIAESLYTNGYISYPRTDNTVYpeSLDLREQIEIFAEGPFGEyaQKLLEKGELVPTRGKKETTdHPPIYPASLAKKSE- 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 380 lkdMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLPLVKQGDRL 459
Cdd:PRK07220 377 ---LKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAP--EDRLLPELSEGEEL 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 460 SLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR----VENRRFYAekmgeiVTDRLEENFR 535
Cdd:PRK07220 452 KVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHgnpiQPTNTAFA------VVDALEKYAP 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 536 DLMNYDFTAQMEDRLDQVANHQA-------EWKEVLNHFFGDfttqLATAEKDPEE---GGMQPNPMVLTsidCPTCGRK 605
Cdd:PRK07220 526 TITKPDMTSRLEEDMDKIAEGKIkedavleESREMLEQVFDE----LDKNREKIREslrEGLREDKIIGK---CPLCGSD 598
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488991000 606 MGIRTASTGV-FLGCSGYAlppkeRCKTTINLVPENEVLnVLEgddaetnalrakRRCQKCG 666
Cdd:PRK07220 599 LMVRRSKRGSrFIGCEGYP-----ECTFSLPLPKSGQII-VTD------------KVCEAHG 642
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-639 |
7.32e-65 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 234.33 E-value: 7.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTATKGAKKPKKDERSALVnrmgvdpwhdwn 80
Cdd:COG1754 3 AAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKADVAKADDKVVDDDDKKDDVDDDKKKKKKLL------------ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 81 ahyeVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNID 160
Cdd:COG1754 71 ----KAAAKKKKALALALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDAsTTTPGGDALPLQVTH 240
Cdd:COG1754 147 LVRRLLVRLLLLRLVLLLLRLLVARRAARRRRRRRRRRARRRELERRRERARAAEAEEAAAAAA-AAADAGRAAAARDGK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 241 KDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPgAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------ 314
Cdd:COG1754 226 GGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPP-TPTTTTTAQAATTTTTRAAAARTTRSAQQAARRtrlgge 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 315 --GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQEAHEAIRPSDVNVLAETLKDMEA--DAQKL 390
Cdd:COG1754 305 gtYTTTTTTTTTTSAAAAAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALLsdDRLLL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 391 YQLIWRQFVACQMTPAQYDSTTLTVAA----GDFKLKARGRTLRFDGWTKVMPALRK---GDEDRTLPLVKQGDRLSLVE 463
Cdd:COG1754 385 ELLLLRRTAAAAAAAAAATATTTAAAAaagaGAVGTAAAGAVFFFGGFLLFAEEEDDdeeDDDDDDLPALEEGLPLLKEG 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFT 543
Cdd:COG1754 465 VLADQHFTQPPPRYTEAPLVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 544 AQMEDRLDQVANHQAEWKEVLNHFFGDFT-TQLATAEKDPEEGGMQPNpmVLTSID------CPTCGRKMGIRTASTGVF 616
Cdd:COG1754 545 ADLEEFLDDVSDGELDWKAVLRRFWRDFSaAYDETGDLRISEVLDALE--DLGEIDpreinsCPLGTGGLSLRVGRYGPF 622
|
650 660
....*....|....*....|....*...
gi 488991000 617 LGCSGYA-----LPPkerCKTTINLVPE 639
Cdd:COG1754 623 IECSNYEprrasIPE---CLAPDELTPE 647
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
3-154 |
7.17e-60 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 198.94 E-value: 7.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadstatkgakkpkkdersalvnrMGVDPWHD-WNA 81
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKG-----------------------------LGVDGEDDgFEP 51
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488991000 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEqRYSRVVFNEITKNAIRQAFEKP 154
Cdd:cd03363 52 KYVVIPGKKKVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVLKLKK-NVKRVVFNEITKEAIKEALKNP 123
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
87-634 |
7.76e-60 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 220.10 E-value: 7.76e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNA 164
Cdd:PRK14973 81 PTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAvnPKVPIDRARFSAITKEEIVTAFAEPTDLDFALAAA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 165 QQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTH 240
Cdd:PRK14973 161 GEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKDGEGIEARHTHG 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 241 K-DDKPFRPVSRDETMAAVSLLEKASYSVLERedKPTsskpgaPFITSTLQQAAStRLGFGVKKTMMMAQRLYEAGHITY 319
Cdd:PRK14973 241 RfTDSAAAEAAYDATKEPLVVTEVKEGHKVDR--APT------PFDTTTFIVAAS-RLGFSAANAMRIAEDLYMNGYISY 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 320 MRTDST------NLSqDALNMVRGyisDKFGKKYLPDSANQYA----SKENSQEaHEAIRPSDVnvlaETLKDMEADAQK 389
Cdd:PRK14973 312 PRTDNTiypkslDLN-GVLATLAK---GAFSKDVAWVKDNRRPvptrGKKSSTD-HPPIHPTGV----ATREELGDDRWK 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 390 LYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLPLVKQGDRLSLVELTPAQH 469
Cdd:PRK14973 383 LYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEA--KENILPAFALGEKLPILAVNLEEK 460
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYvrVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDR 549
Cdd:PRK14973 461 ETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKY--IEGNPLRPTLVGRAVTESLEEHAGTITEPDMTQTLEEH 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 550 LDQVANHQ-------AEWKEVLNHFFGDFttqlataEKDPEEGG---MQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGC 619
Cdd:PRK14973 539 MQQIKERKrtrddvvTESRKMLHRAFDEL-------EANEAVIGrdiMERTAEELTIGPCPVCGKDLRIKHIGSSQFIGC 611
|
570
....*....|....*
gi 488991000 620 SGYalpPKERCKTTI 634
Cdd:PRK14973 612 SGY---PDCTFNIGL 623
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
43-738 |
1.77e-52 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 195.47 E-value: 1.77e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 43 ASKKSADSTATKGAKKPKKDERSALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122
Cdd:COG0551 22 KKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 123 LREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVR 202
Cdd:COG0551 102 AADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLLLAAGRLRLLSAVA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 203 LVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGA 282
Cdd:COG0551 182 AGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-------------GHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLP 349
Cdd:COG0551 262 KELPTTTTDALPEALATTSLTAAAAASALAAAlleeegellytggYIRYTRTPKSSEADALAALEALKKIAEEPPDERAK 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 350 DSANQYASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQ-LIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRT 428
Cdd:COG0551 342 KKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLElLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 429 LRFDGWTKVMPAlrKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508
Cdd:COG0551 422 LEVLGEEEEDDE--DEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTTATIIILILKRR 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 509 YVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGmQ 588
Cdd:COG0551 500 YVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEE-L 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 589 PNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalpPKerCKTTINLvPENEVLNVlegddaetnalrakrRCQKCGTA 668
Cdd:COG0551 579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNY---PE--CKYTKPL-PKPEVTGV---------------KCPKCGKK 637
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488991000 669 MDsyLIDPK--RKLHVCGNNPTCDgyeieegeFRIKgyDGPV-VECEKCGSEMHLKMGRFGkymaCTNDECKN 738
Cdd:COG0551 638 LV--LRKSKkgKVFYGCSNYPKCK--------FTEW--DKPVkEPCPKCGSPLVEKKTKKG----CANKLCGY 694
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
5-554 |
2.65e-50 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 190.54 E-value: 2.65e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 5 LVIVESPAKAKTINKYLGNDYVVKS---SVGHIRDLPTSgsASKKSADST-----ATKGAKKPKKDERSALVNRMGVDPW 76
Cdd:PTZ00407 12 LVIVESPNKVIKVEGLLSDPKVIPDwsfKQSHLRRIGTG--AEKAVAMATtghfmALKEITWSPQASSPASVVGAGDEPF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 77 H------DWNAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIggdeQR--------YSRVVF 139
Cdd:PTZ00407 90 PsngtlaEYTLEWELLPGRriqETLERYIEEKADNVTEIILATDPDREGELIAVHALQTI----KRlypklkvpFSRAYM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 140 NEITKNAIRQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPE 217
Cdd:PTZ00407 166 HSITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDKIKAFLES 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 218 E--YWEVDAST--TTPGGDALPLQVT-HKDDKPFRPVSRDETMAAVSL----LEKASYSVLEREDKPTSSK--PGAPFIT 286
Cdd:PTZ00407 246 NksTFEVQAMCqfPSPHGTTFSQVVTiTPDRKGGASHWATEAEARRCLeqwkLNNCTGFSVPLEPKPQPSVvpPPQPFTM 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYL------------------ 348
Cdd:PTZ00407 326 ATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYAAVKKEFGKEFLyrledrtvsaqegkgskk 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 349 PDSANQYASKENS-------QEAHEAIRPSDVNVLAETLKdMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTV----AA 417
Cdd:PTZ00407 406 TGKKRSTKQKKGAdtpvgnvEDAHEAIRPTNIDTTGESLS-LSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVkftsGS 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 418 GD-FKLKARGRTLRFDGWTKvmpALRKGDEDRTLPLV-------------------------------------KQGDRL 459
Cdd:PTZ00407 485 GEkLEFELQGKRVVEPGWTR---AFHKGDKGTTGPAEetdeditaveegapvvpslsqeefkaimnlrsqlgsgVQKGFF 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 460 SLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIVTDRLEENFRDLM 538
Cdd:PTZ00407 562 ELRSPQVRENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETAKSTFPSIV 641
|
650
....*....|....*.
gi 488991000 539 NYDFTAQMEDRLDQVA 554
Cdd:PTZ00407 642 DIGFTAAFEKKLDRIA 657
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-515 |
6.26e-45 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 174.47 E-value: 6.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 1 MGKALVIVESPAKAKTINKYLG-----------NDYVVKSSVGHIRDLptsgsaskksadstatkgaKKPKKDErsalVN 69
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARALGgftkhdeyfesDEYVLSSAVGHLLEI-------------------AAPEEYE----VK 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 70 RmgvdpwHDWN-AHYEVLPGK------EKVVSELKQLAEKA-----DHIYLATDLDREGEAIAWHLREVIGGDeQRYSRV 137
Cdd:PRK08173 58 R------GKWSfAHLPVIPPHfdlnpiAKTESRLKVLTKLIkrkdvTRLINACDAGREGELIFRLIAQHAKAK-KPVKRL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 138 VFNEITKNAIRQAFEK--PGELNIDRVNAQQARRFMDRVVGYMVSpllwkkiaRGLSA-------------GRVQSVAVR 202
Cdd:PRK08173 131 WLQSMTPQAIRDGFANlrSDEDMQPLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPTLS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 203 LVVEREREIKAFVPEEYWEVDASTTTPGGDA----LPLQVTHKDDKPFRPVSR--DETmAAVSLLEKA---SYSVLErED 273
Cdd:PRK08173 203 IVVEREEKIRRFVPRDYWEVRAEFVAAAGFYegrwFDPKFKKDEFDPEKRASRlwSEA-AAEAIVAACrgkPGTVTE-ES 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 274 KPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAgH--ITYMRTDSTNLSQDALNMVR----------GYisD 341
Cdd:PRK08173 281 KPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEK-HkvLTYPRTDSRALPEDYLGTVKqtlemlkesnNY--L 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 342 KFGKKYLpdsANQY--ASK---ENSQEA-HEAIRPSdvNVLAETLKDMEadaQKLYQLIWRQFVACQMTPAQYDSTT-LT 414
Cdd:PRK08173 358 PHAKQIL---DKGWvkPNKrifDNSKISdHFAIIPT--LQAPKSLSEPE---QKLYDLVVKRFLAVFFPAAEFLVTTrIT 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 415 VAAGDfKLKARGRTLRFDGWTKVMpALRKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELE------- 487
Cdd:PRK08173 430 EVAGH-HFKTEGKVLVNPGWLAVY-GKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklve 507
|
570 580 590
....*....|....*....|....*....|....*..
gi 488991000 488 ---------KRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK08173 508 ddelreamaEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
134-221 |
2.34e-43 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 151.58 E-value: 2.34e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 134 YSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIK 212
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIK 80
|
....*....
gi 488991000 213 AFVPEEYWE 221
Cdd:smart00436 81 NFVPKPYWE 89
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-154 |
1.01e-42 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 151.99 E-value: 1.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYLG------------NDYVVKSSVGHIRDLPTSGsaskksadstatKGAKKPKKDERsalvnr 70
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGkgskkkgfygegGGYVVTASVGHLLELPFPE------------EYVDWDKDWPL------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 71 mgvdPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQA 150
Cdd:cd01028 63 ----ELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREA 138
|
....
gi 488991000 151 FEKP 154
Cdd:cd01028 139 FKNL 142
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-603 |
2.57e-36 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 148.18 E-value: 2.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTI--------------NKYLGND-YVVKSSVGHIRDLptsgsaskKSADSTATKGAKkpkkdersal 67
Cdd:PRK14724 2 KTLVIAEKPSVAQDIvraltpvagkfekhDEHFESDsYVVTSAVGHLVEI--------QAPEEFDVKRGK---------- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 68 vnrmgvdpwhdWN-AHYEVLPGK------EKVVSELK---QLAEKADHIYL--ATDLDREGEAIAWHLREVIGGDEQRYS 135
Cdd:PRK14724 64 -----------WSfANLPVIPPYfdlkpvDKTKTRLNavvKLAKRKDVTELvnACDAGREGELIFRLIEQYAGGAKGGLG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 136 RVV----FNEITKNAIRQAFE--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLV 204
Cdd:PRK14724 133 KPVkrlwLQSMTPQAIRDGFDnlRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDggfflTTVGRVQTPTLSLV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 205 VEREREIKAFVPEEYWEVDASTTTPGGDAL-----PLQVTHKDD---KPFRPVSRDETMAAVSLLEKASYSVLErEDKPT 276
Cdd:PRK14724 213 VEREEKIRKFVSRDYWEIHAGFHAEAGEYLgkwfdPQWKKASDDpeaRADRVWSEREARAIADAVRGKAATVTE-ESKPT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 277 SSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGH-ITYMRTDSTNLSQDALNMVR---GYISDKfGKKYLPDSA 352
Cdd:PRK14724 292 TQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKaLTYPRTDSRALPEDYLPVAKqtfEMLATS-GMRHLAPFA 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 353 NQyASKEN----SQEAHEAIRPSDVNVLAETLKD----MEADaQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKA 424
Cdd:PRK14724 371 QQ-ALDGNyvrpSKRIFDNSKVSDHFAIIPTTQApsglSEAE-QKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKT 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 425 RGRTLRFDGWTKV--------MPALRKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELE--------- 487
Cdd:PRK14724 449 EGKVLVKPGWLAIygkeaaneVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqiddd 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 488 -------KRGIGRPSTYASIISTIQDRGYVRVENRRFY-AEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAE 559
Cdd:PRK14724 529 elreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIpTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLS 608
|
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 488991000 560 wKEVLNHFFGDFTTQLATAEKDPEEGGMqPNPMVLTSIDCPTCG 603
Cdd:PRK14724 609 -REAFMQQIAAMTEKLVKKAKEYDRDTI-PGDYATLSTPCPNCG 650
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
824-862 |
5.00e-20 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 83.48 E-value: 5.00e-20
10 20 30
....*....|....*....|....*....|....*....
gi 488991000 824 GNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDGKWTE 862
Cdd:pfam08272 1 GNPALVRFSRKTKEQYVLSEVDGKATGWLAAYTDGKWRE 39
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-154 |
7.90e-20 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 86.90 E-value: 7.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTI------------------NKYLGNDYVVKSSVGHIRDLptsgsaskksadstatkgakkpkkDER 64
Cdd:cd03362 1 MVLIIAEKPSVAKAIakilgggskkkgkgryyeFYGEGGGYVVTWASGHLLEL------------------------DFP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 65 SALVNRMGVDPWHD----WNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG-GDEQRYSRVVF 139
Cdd:cd03362 57 EEYDPWDKVWPLEDplfpAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKcVKRKPVKRAWF 136
|
170
....*....|....*
gi 488991000 140 NEITKNAIRQAFEKP 154
Cdd:cd03362 137 SSLTPKAIRRAFKNL 151
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-142 |
5.51e-19 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 82.40 E-value: 5.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 4 ALVIVESPAKAKTINKYLG-NDYVVKSSVGHIRDLPTsgsaskksadstatkgakkpkkdersalvnrmgvdpwhdwnah 82
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGgGFQAVVAVLGHLLSLEK------------------------------------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 83 yevlPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEI 142
Cdd:pfam01751 38 ----GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
4-154 |
2.58e-17 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 80.44 E-value: 2.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSGSASKKSADstatKGAKKP----- 59
Cdd:cd03361 2 ALMIVESPNKARTIANFFGrpsvrrlgglvvyevstGDGVlmITASGGHVYDLVTKEGGHGVVED----DGRYVPvydsi 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 60 KK--DERSALVNRMGVDPwhdwNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRV 137
Cdd:cd03361 78 KRcrDCGYQFTEDSDKCP----RCGSENIDDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALRPYNKNIKRA 153
|
170
....*....|....*..
gi 488991000 138 VFNEITKNAIRQAFEKP 154
Cdd:cd03361 154 EFHEVTRRAILEALRNP 170
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
3-130 |
4.50e-15 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 70.75 E-value: 4.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaskksadstatkgakkpkkdersalvnrmgvdpwhdwnah 82
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRGNVVALGGHLL----------------------------------------------- 33
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 488991000 83 yevlpgKEKVVSELKQLAEKAdHIYLATDLDREGEAIAWHLREVIGGD 130
Cdd:smart00493 34 ------SKEQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPA 74
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
708-745 |
7.87e-13 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 63.05 E-value: 7.87e-13
10 20 30
....*....|....*....|....*....|....*....
gi 488991000 708 VVECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRN 745
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFVGCSNyPECRFTRPLKKN 39
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
3-139 |
1.61e-10 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 58.21 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488991000 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaskksadstatkgakkpkkdersalvnrmgvdpwhdwnah 82
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHAL----------------------------------------------- 33
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 488991000 83 yevlpgkEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVF 139
Cdd:cd00188 34 -------NKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
757-791 |
2.50e-07 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 47.66 E-value: 2.50e-07
10 20 30
....*....|....*....|....*....|....*....
gi 488991000 757 PLPELP--CEKSDAYFVLR--DGAAGVFLAANTFPKSRE 791
Cdd:pfam08272 1 GNPALVrfSRKTKEQYVLSevDGKATGWLAAYTDGKWRE 39
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
597-638 |
7.02e-05 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 40.70 E-value: 7.02e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 488991000 597 IDCPTCGRKMGIRTASTGVFLGCSGYalpPKerCKTTINLVP 638
Cdd:pfam01396 2 GKCPKCGGDLVLKRGRFGKFVGCSNY---PE--CRFTRPLKK 38
|
|
| |
