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Conserved domains on  [gi|488990970|ref|WP_002901733|]
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MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF [Klebsiella]

Protein Classification

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase( domain architecture ID 11484157)

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase catalyzes the fourth and fifth steps of tryptophan biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


:

Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 901.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  81 ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 161 LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 241 EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 321 ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLHHVDKYLLDNGQGGSGQRFDWSLLQGQDLR 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488990970 401 NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGMKDASKLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 901.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  81 ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 161 LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 241 EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 321 ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLHHVDKYLLDNGQGGSGQRFDWSLLQGQDLR 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488990970 401 NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGMKDASKLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.51e-132

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 382.45  E-value: 1.51e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEI--VPTQRNFYDAL-AGTRTAFILECKKASPSKGLIREDFDPAAIASIYK 78
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALrAAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  79 HY-ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLN 157
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 158 MGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVREL-SHFANGFLIG 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240

                        250
                 ....*....|....*..
gi 488990970 237 SALMEQADLEAAVKRVL 253
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-251 4.67e-131

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 378.56  E-value: 4.67e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970    5 LAKIVADKAIWVEARKQQQPLASFQNEI-VPTQRNFYDALAGT--RTAFILECKKASPSKGLIREDFDPAAIASIYKHY- 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   81 ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  161 LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELS-HFANGFLIGSAL 239
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240

                         250
                  ....*....|..
gi 488990970  240 MEQADLEAAVKR 251
Cdd:pfam00218 241 MRQEDVRAAIRE 252
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 39-252 5.67e-106

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 313.25  E-value: 5.67e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  39 FYDALAGT-RTAFILECKKASPSKGLIREDFDPAAIASIYKHY-ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDF 116
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 117 TIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLN 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488990970 197 RTRQLAARLGPDVTVISESGIHTYAEVREL-SHFANGFLIGSALMEQADLEAAVKRV 252
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 901.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEIVPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  81 ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 161 LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 241 EQADLEAAVKRVLLGENKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 321 ARAQALGLAAVQLHGDEDQAYIDALRDALADNVRIWKALSVGETFPARTLHHVDKYLLDNGQGGSGQRFDWSLLQGQDLR 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488990970 401 NVMLAGGLGADNCVEAAKSGCAGLDFNSGVESQPGMKDASKLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.51e-132

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 382.45  E-value: 1.51e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEI--VPTQRNFYDAL-AGTRTAFILECKKASPSKGLIREDFDPAAIASIYK 78
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALrAAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  79 HY-ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLN 157
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 158 MGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVREL-SHFANGFLIG 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240

                        250
                 ....*....|....*..
gi 488990970 237 SALMEQADLEAAVKRVL 253
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-251 4.67e-131

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 378.56  E-value: 4.67e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970    5 LAKIVADKAIWVEARKQQQPLASFQNEI-VPTQRNFYDALAGT--RTAFILECKKASPSKGLIREDFDPAAIASIYKHY- 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   81 ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  161 LTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELS-HFANGFLIGSAL 239
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240

                         250
                  ....*....|..
gi 488990970  240 MEQADLEAAVKR 251
Cdd:pfam00218 241 MRQEDVRAAIRE 252
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-256 1.84e-111

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 328.65  E-value: 1.84e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEI--VPTQRNFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIY- 77
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARAaaAPPPRDFAAALRAGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYe 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  78 KHYASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLN 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 158 MGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVREL-SHFANGFLIG 236
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLaKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 488990970 237 SALMEQADLEAAVKRVLLGE 256
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 39-252 5.67e-106

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 313.25  E-value: 5.67e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  39 FYDALAGT-RTAFILECKKASPSKGLIREDFDPAAIASIYKHY-ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDF 116
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 117 TIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLN 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488990970 197 RTRQLAARLGPDVTVISESGIHTYAEVREL-SHFANGFLIGSALMEQADLEAAVKRV 252
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
PRAI pfam00697
N-(5'phosphoribosyl)anthranilate (PRA) isomerase;
257-447 1.01e-72

N-(5'phosphoribosyl)anthranilate (PRA) isomerase;


Pssm-ID: 395566  Cd Length: 193  Bit Score: 227.23  E-value: 1.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  257 NKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAPLQYVGVFRNAPLEEVVARAQALGLAAVQLHGD 336
Cdd:pfam00697   1 AKICGLTRLSDVKAAVKAGADYLGLIFSESSKRQVSPEQAQELRSPVPLLLVGVFVNQPIDDVLRIAQVLGLDVVQLHGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  337 EDQAYIDALRDALADNVRIWKALSVGETFPARTLHHVDKYLLDNGQGGSGQRFDWSLLQG--QDLRNVMLAGGLGADNCV 414
Cdd:pfam00697  81 EDQEYENLLPTGVPVIKAIWVPDSVDTVDIARRADHVDLPLLDSGAGGTGELFDWSLVSKwlKSGLKVILAGGLNPDNVV 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 488990970  415 EAAKS-GCAGLDFNSGVESQpGMKDASKLASVFQ 447
Cdd:pfam00697 161 EAIKTpGVIGVDVSSGVETN-GIKDLNKIRKFVQ 193
TrpF COG0135
Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; ...
 257-451 3.42e-72

Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Phosphoribosylanthranilate isomerase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439905  Cd Length: 208  Bit Score: 226.56  E-value: 3.42e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 257 NKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAP--LQYVGVFRNAPLEEVVARAQALGLAAVQLH 334
Cdd:COG0135    4 VKICGLTRPEDARAAVEAGADALGFVFYPKSPRYVSPEQAAELAAALPpfVKKVGVFVNADPEEILEIVEAVGLDAVQLH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 335 GDEDQAYIDALRDALadNVRIWKALSVGETFPARTL----HHVDKYLLD----NGQGGSGQRFDWSLLQGQDL-RNVMLA 405
Cdd:COG0135   84 GDESPEYCAALRERL--GLPVIKAIRVGDGADLEEAaayaPVADALLLDakvpGLYGGTGKTFDWSLLAGLALpKPVILA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488990970 406 GGLGADNCVEA-AKSGCAGLDFNSGVESQPGMKDASKLASVFQTLRA 451
Cdd:COG0135  162 GGLTPENVAEAiRLVRPYGVDVSSGVESAPGVKDPDKIRAFVEAVRA 208
PRAI cd00405
Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan ...
 257-447 6.54e-68

Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.


Pssm-ID: 238237  Cd Length: 203  Bit Score: 215.13  E-value: 6.54e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 257 NKVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAP--LQYVGVFRNAPLEEVVARAQALGLAAVQLH 334
Cdd:cd00405    1 VKICGITTLEDALAAAEAGADAIGFIFAPKSPRYVSPEQAREIVAALPpfVKRVGVFVNEDLEEILEIAEELGLDVVQLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 335 GDEDQAYIDALRDALadNVRIWKALSVGETFP----ARTLHHVDKYLLDN----GQGGSGQRFDWSLLQGQDLR-NVMLA 405
Cdd:cd00405   81 GDESPEYCAQLRARL--GLPVIKAIRVKDEEDlekaAAYAGEVDAILLDSksggGGGGTGKTFDWSLLRGLASRkPVILA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 488990970 406 GGLGADNCVEA-AKSGCAGLDFNSGVESQPGMKDASKLASVFQ 447
Cdd:cd00405  159 GGLTPDNVAEAiRLVRPYGVDVSSGVETSPGIKDPEKIRAFIE 201
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 2-257 2.12e-59

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 197.69  E-value: 2.12e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEI--VPTQRNFYDAL--AGTRT---AFILECKKASPSKGLIREDFDPAAIA 74
Cdd:PLN02460  66 RNILEEIVWYKDVEVAQMKERKPLYLLKKALqnAPPARDFVGALraAHKRTgqpGLIAEVKKASPSRGVLRENFDPVEIA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  75 SIY-KHYASAISVLCDEKYFQGSFDFLPIVSQVAPQ-PILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAV 152
Cdd:PLN02460 146 QAYeKGGAACLSVLTDEKYFQGSFENLEAIRNAGVKcPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKI 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 153 AHSLNMGVLTEVSNEEELERAIALKA-KVVGINNRDLRDMSIDLNRTRQL-AARLGP-----DVTVISESGIHT---YAE 222
Cdd:PLN02460 226 CKSLGMAALIEVHDEREMDRVLGIEGvELIGINNRSLETFEVDISNTKKLlEGERGEqirekGIIVVGESGLFTpddVAY 305

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 488990970 223 VRELSHFAngFLIGSALMEQADLEAAVKRvLLGEN 257
Cdd:PLN02460 306 VQNAGVKA--VLVGESLVKQDDPGKGIAG-LFGKD 337
PRK01222 PRK01222
phosphoribosylanthranilate isomerase;
258-452 1.43e-47

phosphoribosylanthranilate isomerase;


Pssm-ID: 234923  Cd Length: 210  Bit Score: 162.67  E-value: 1.43e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 258 KVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAV--NDAQAKAVIAAAPLQYVGVFRNAPLEEVVARAQALGLAAVQLHG 335
Cdd:PRK01222   6 KICGITTPEDAEAAAELGADAIGFVFYPKSPRYVspEQAAELAAALPPFVKVVGVFVNASDEEIDEIVETVPLDLLQLHG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 336 DEDQAYIDALRDALadNVRIWKALSVGETFPARTLHH----VDKYLLD---NGQGGSGQRFDWSLLQGQDLRNVMLAGGL 408
Cdd:PRK01222  86 DETPEFCRQLKRRY--GLPVIKALRVRSAGDLEAAAAyygdADGLLLDayvGLPGGTGKTFDWSLLPAGLAKPWILAGGL 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488990970 409 GADNCVEA-AKSGCAGLDFNSGVESQPGMKDASKLASVFQTLRAY 452
Cdd:PRK01222 164 NPDNVAEAiRQVRPYGVDVSSGVESAPGIKDPEKIRAFIEAVKSA 208
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 1-248 5.46e-46

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 159.66  E-value: 5.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970   1 MQTVLAKIVADKAIWVEARKQQQPLasfqneivPTQR-NFYDALAGTRTAFILECKKASPSKGLIREDFDPAAIASIYKH 79
Cdd:PRK13957   1 MHRVLREIIETKQNEIEKISRWDPL--------PDRGlPLRDSLKSRSFSIIAECKRKSPSAGELRADYHPVQIAKTYET 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  80 Y-ASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLNM 158
Cdd:PRK13957  73 LgASAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGM 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 159 GVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDVTVISESGIHTYAEVRELSHFANGFLIGSA 238
Cdd:PRK13957 153 DVLVEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLPPNIVKVGESGIESRSDLDKFRKLVDAALIGTY 232

                        250
                 ....*....|
gi 488990970 239 LMEQADLEAA 248
Cdd:PRK13957 233 FMEKKDIRKA 242
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 51-253 1.54e-45

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 168.28  E-value: 1.54e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  51 ILECKKASPSKGLIREDFDPAAIASIY-KHYASAISVLCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIYLARYY 129
Cdd:PRK13802  53 IAEIKRASPSKGHLSDIPDPAALAREYeQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAH 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 130 QADACLLMLSVLDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRTRQLAARLGPDV 209
Cdd:PRK13802 133 GADLVLLIVAALDDAQLKHLLDLAHELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDV 212

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488990970 210 TVISESGIHTYAEVRELSHF-ANGFLIGSALMEQADLEAAVKRVL 253
Cdd:PRK13802 213 IKVAESGVFGAVEVEDYARAgADAVLVGEGVATADDHELAVERLV 257
PLN02363 PLN02363
phosphoribosylanthranilate isomerase
 258-444 2.06e-30

phosphoribosylanthranilate isomerase


Pssm-ID: 215207  Cd Length: 256  Bit Score: 118.42  E-value: 2.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 258 KVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQA---KAVIAAAPLQYVGVFRNAPLEEVVARAQALGLAAVQLH 334
Cdd:PLN02363  50 KMCGITSARDAAMAVEAGADFIGMILWPKSKRSISLSVAkeiSQVAREGGAKPVGVFVDDDANTILRAADSSDLELVQLH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 335 GDEDqayidalRDALADNVRIWKALSV---------GETFPARTLHHVDKYLLDNGQGGSGQRFDWSLLQ---GQDLRNV 402
Cdd:PLN02363 130 GNGS-------RAAFSRLVRERKVIYVlnanedgklLNVVPEEDCHLADWILVDSATGGSGKGFNWQNFKlpsVRSRNGW 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488990970 403 MLAGGLGADNCVEAAkSGCA--GLDFNSGVESQPGM-KDASKLAS 444
Cdd:PLN02363 203 LLAGGLTPENVHEAV-SLLKptGVDVSSGICGPDGIrKDPSKISS 246
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
 258-450 4.33e-19

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 89.87  E-value: 4.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 258 KVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAP----LQYVGVFRNAPLEEVVARAQALGLAAVQL 333
Cdd:PRK13803   6 KICGIKDSALISKAVDMLPDFIGFIFYEKSPRFVGNKFLAPNLEKAIrkagGRPVGVFVNESAKAMLKFSKKNGIDFVQL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 334 HGDEDQAYIDALRDALADNVRIWKALSVGETFPARTL----HHVDKYLLDN---GQGGSGQRFDWSLLQGQDLRNV-MLA 405
Cdd:PRK13803  86 HGAESKAEPAYCQRIYKKSIKKIGSFLIDDAFGFEVLdeyrDHVKYFLFDNktkIYGGSGKSFDWEKFYNYNFKFPfFLS 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488990970 406 GGLGADN---CVEAAKSGCAGLDFNSGVESQPGMKDASKLASVFQTLR 450
Cdd:PRK13803 166 GGLSPTNfdrIINLTHPQILGIDVSSGFEDSPGNKKLTLLKSFITNVK 213
PRK13958 PRK13958
N-(5'-phosphoribosyl)anthranilate isomerase; Provisional
 258-450 5.50e-17

N-(5'-phosphoribosyl)anthranilate isomerase; Provisional


Pssm-ID: 184418  Cd Length: 207  Bit Score: 79.38  E-value: 5.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 258 KVCGLTRPQDAQVAWESGAIYGGLIFVPTSPRAVNDAQAKAVIAAAP--LQYVGVFRNAPLEEVVARAQALGLAAVQLHG 335
Cdd:PRK13958   4 KFCGFTTIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPnhIDKVCVVVNPDLTTIEHILSNTSINTIQLHG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 336 DEDQAYIDALRDaLADNVRIWKALSVGETFPART---LHHVDKYLLDNGQ---GGSGQRFDWSLLQG-QDLrNVMLAGGL 408
Cdd:PRK13958  84 TESIDFIQEIKK-KYSSIKIIKALPADENIIQNInkyKGFVDLFIIDTPSvsyGGTGQTYDWTILKHiKDI-PYLIAGGI 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488990970 409 GADNC--VEAAKSGCAGLDFNSGVESQpGMKDASKLASVFQTLR 450
Cdd:PRK13958 162 NSENIqtVEQLKLSHQGYDIASGIETN-GRKDINKMTAIVNIVK 204
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 67-237 7.14e-10

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 58.37  E-value: 7.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970  67 DFDPAAIASIYKHY-ASAISV----LCDEKYFQGSFDFLPIVSQVAPQPILCKDFTIDPYQIY-----LARYYQADACLL 136
Cdd:cd04722   11 SGDPVELAKAAAEAgADAIIVgtrsSDPEEAETDDKEVLKEVAAETDLPLGVQLAINDAAAAVdiaaaAARAAGADGVEI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488990970 137 MLSV-----LDDEQYRQLSAVAHSLNMGVLTEVSNEEELERAIALKAKVVGINNRDLRDMSIDLNRT---RQLAARLGPD 208
Cdd:cd04722   91 HGAVgylarEDLELIRELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAVPIadlLLILAKRGSK 170

                        170       180       190
                 ....*....|....*....|....*....|
gi 488990970 209 VTVISESGIHTYAEVRELSHF-ANGFLIGS 237
Cdd:cd04722  171 VPVIAGGGINDPEDAAEALALgADGVIVGS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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