|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-489 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 654.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:PRK05826 2 MLRRTKIVATLGPASD---------------------SPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEGdaKEYSYKTGEKIRVATKQGIKSTRDVIALNVAgalDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:PRK05826 61 RPVAILLDLKGPKIRVGKFKE--GKITLKTGDKFTLDTDQKEEGDKERVGVDYK---GLPKDVKPGDILLLDDGKLQLKV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDAtrEFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:PRK05826 136 VEVDGD--EVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGC 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PRK05826 214 PHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLL--NEYGRLTTDNFERNsKTEVMASAVKDATNSM 398
Cdd:PRK05826 294 AEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFsiNLSKHRLDRQFDRI-DEAIAMSAMYAANHLK 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 399 DIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDI 478
Cdd:PRK05826 373 GVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLV 452
|
490
....*....|.
gi 488985134 479 VIVAGVPLGEA 489
Cdd:PRK05826 453 VVTSGDPMGTA 463
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-500 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 618.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:COG0469 1 MMRRTKIVATLGPASD---------------------SPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEGDAKEYsyKTGEKIRVATKQgIKSTRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:COG0469 60 RPVAILLDLQGPKIRTGKFKEGPVEL--KKGDTFTLTTDD-VEGDAERVSVTYPE---LPEDVKPGDRILLDDGKIELRV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDatREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGn 240
Cdd:COG0469 134 EEVEG--DEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:COG0469 211 GRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRL-TTDNFERNSKTEVMASAVKDATNSMD 399
Cdd:COG0469 291 AEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILdRLRDEPERTITDAIARAAVELAEDLG 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 400 IKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIV 479
Cdd:COG0469 371 AKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVV 450
|
490 500
....*....|....*....|.
gi 488985134 480 IVAGVPLGEAVRTNTMRIRTV 500
Cdd:COG0469 451 ITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
2-500 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 608.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQ 81
Cdd:cd00288 1 LRRTKIVCTIGPATD---------------------SVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 82 KVGFLLDTKGPEIRTELFEGDaKEYSYKTGEKIRVATKQG-IKSTRDVIALNVagaLDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:cd00288 60 PVAIALDTKGPEIRTGLFKGG-KDISLKAGDKFLVTTDPAaKKGTKEKIYVDY---KNLTKDVSPGNTILVDDGLLSLKV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDAtREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:cd00288 136 LSKDDD-KTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 gHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:cd00288 215 -DIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRLTTDNFE---RNSKTEVMASAVKDATNS 397
Cdd:cd00288 294 AEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLtprPTSTTEAVAMSAVRAAFE 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 398 MDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETP-----SNTDDMFEIAEKIAVEQGLV 472
Cdd:cd00288 374 LGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLL 453
|
490 500
....*....|....*....|....*...
gi 488985134 473 ESGDDIVIVAGVPLGEAvRTNTMRIRTV 500
Cdd:cd00288 454 KKGDLVVVVQGWPVGSG-STNTMRILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-497 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 518.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 3 KRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:TIGR01064 1 RRTKIVCTIGPATN---------------------SPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRP 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 VGFLLDTKGPEIRTELFEGDakEYSYKTGEKIRVATKQGIK-STRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRVF 161
Cdd:TIGR01064 60 VAILLDTKGPEIRTGEIKGG--EVKLKKGDKVIITTDDIKGeGDEEKVYVDYKG---LTKDVVEGDKILVDDGKISLVVV 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 162 SKDDAtrEFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGNG 241
Cdd:TIGR01064 135 SVEGD--KVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 242 HVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATRS 321
Cdd:TIGR01064 213 DVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 322 EVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNA------QTLLNEYGRLTTdnfERNSKTEVMASAVKDAT 395
Cdd:TIGR01064 293 EVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAekalayLTNFNDRKNSDP---KPSTITEAIALSAVEAA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 396 NSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPV-TTETPSNTDDMFEIAEKIAVEQGLVES 474
Cdd:TIGR01064 370 EKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKK 449
|
490 500
....*....|....*....|...
gi 488985134 475 GDDIVIVAGVPLGEAVRTNTMRI 497
Cdd:TIGR01064 450 GDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
2-373 |
1.96e-170 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 484.18 E-value: 1.96e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQ 81
Cdd:pfam00224 1 LRRTKIVCTIGPASN---------------------SVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 82 KVGFLLDTKGPEIRTELFEGDAKEYSYKTGEKIRVATKQGIKSTRD--VIALNVAGaldIYDDVEVGHQVLVDDGKLGLR 159
Cdd:pfam00224 60 TVAIALDTKGPEIRTGNTKDGKKDIELKAGDEMIVSTDAKYKGACDdeMIYVDYKN---IVKDVSVGGTILVDDGLLSLK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 160 VFSKDDATReFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETG 239
Cdd:pfam00224 137 VLSKDDDKT-LVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 240 NgHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRAT 319
Cdd:pfam00224 216 K-NIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPT 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488985134 320 RSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRL 373
Cdd:pfam00224 295 RAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-489 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 654.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:PRK05826 2 MLRRTKIVATLGPASD---------------------SPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEGdaKEYSYKTGEKIRVATKQGIKSTRDVIALNVAgalDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:PRK05826 61 RPVAILLDLKGPKIRVGKFKE--GKITLKTGDKFTLDTDQKEEGDKERVGVDYK---GLPKDVKPGDILLLDDGKLQLKV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDAtrEFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:PRK05826 136 VEVDGD--EVETEVKNGGPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGC 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PRK05826 214 PHAKIIAKIERAEAVDNIDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLL--NEYGRLTTDNFERNsKTEVMASAVKDATNSM 398
Cdd:PRK05826 294 AEVSDVANAVLDGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFsiNLSKHRLDRQFDRI-DEAIAMSAMYAANHLK 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 399 DIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDI 478
Cdd:PRK05826 373 GVKAIVALTESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLV 452
|
490
....*....|.
gi 488985134 479 VIVAGVPLGEA 489
Cdd:PRK05826 453 VVTSGDPMGTA 463
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-500 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 618.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:COG0469 1 MMRRTKIVATLGPASD---------------------SPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEGDAKEYsyKTGEKIRVATKQgIKSTRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:COG0469 60 RPVAILLDLQGPKIRTGKFKEGPVEL--KKGDTFTLTTDD-VEGDAERVSVTYPE---LPEDVKPGDRILLDDGKIELRV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDatREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGn 240
Cdd:COG0469 134 EEVEG--DEVVCEVVNGGVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAG- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:COG0469 211 GRAPIIAKIEKPEAVENLDEIIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRL-TTDNFERNSKTEVMASAVKDATNSMD 399
Cdd:COG0469 291 AEVSDVANAVLDGTDAVMLSGETAVGKYPVEAVETMARIAEEAEKSLDYRRILdRLRDEPERTITDAIARAAVELAEDLG 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 400 IKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIV 479
Cdd:COG0469 371 AKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVV 450
|
490 500
....*....|....*....|.
gi 488985134 480 IVAGVPLGEAVRTNTMRIRTV 500
Cdd:COG0469 451 ITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
2-500 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 608.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQ 81
Cdd:cd00288 1 LRRTKIVCTIGPATD---------------------SVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 82 KVGFLLDTKGPEIRTELFEGDaKEYSYKTGEKIRVATKQG-IKSTRDVIALNVagaLDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:cd00288 60 PVAIALDTKGPEIRTGLFKGG-KDISLKAGDKFLVTTDPAaKKGTKEKIYVDY---KNLTKDVSPGNTILVDDGLLSLKV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDAtREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:cd00288 136 LSKDDD-KTLVCEVLNGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 gHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:cd00288 215 -DIKIIAKIENQEGVNNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRLTTDNFE---RNSKTEVMASAVKDATNS 397
Cdd:cd00288 294 AEVSDVANAVLDGTDCVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLtprPTSTTEAVAMSAVRAAFE 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 398 MDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETP-----SNTDDMFEIAEKIAVEQGLV 472
Cdd:cd00288 374 LGAKAIVVLTTSGRTARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLL 453
|
490 500
....*....|....*....|....*...
gi 488985134 473 ESGDDIVIVAGVPLGEAvRTNTMRIRTV 500
Cdd:cd00288 454 KKGDLVVVVQGWPVGSG-STNTMRILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-497 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 518.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 3 KRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:TIGR01064 1 RRTKIVCTIGPATN---------------------SPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRP 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 VGFLLDTKGPEIRTELFEGDakEYSYKTGEKIRVATKQGIK-STRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRVF 161
Cdd:TIGR01064 60 VAILLDTKGPEIRTGEIKGG--EVKLKKGDKVIITTDDIKGeGDEEKVYVDYKG---LTKDVVEGDKILVDDGKISLVVV 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 162 SKDDAtrEFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGNG 241
Cdd:TIGR01064 135 SVEGD--KVICEVLNGGTLKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 242 HVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATRS 321
Cdd:TIGR01064 213 DVKIIAKIENQEGVDNIDEIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 322 EVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNA------QTLLNEYGRLTTdnfERNSKTEVMASAVKDAT 395
Cdd:TIGR01064 293 EVSDVANAVLDGTDAVMLSGETAKGKYPVEAVQMMAKIAKEAekalayLTNFNDRKNSDP---KPSTITEAIALSAVEAA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 396 NSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPV-TTETPSNTDDMFEIAEKIAVEQGLVES 474
Cdd:TIGR01064 370 EKLDAKAIVVLTESGRTARLLSKYRPNAPIIAVTPNERVARQLALYWGVFPFlVDEEPSDTDARVNKALELLKEKGIVKK 449
|
490 500
....*....|....*....|...
gi 488985134 475 GDDIVIVAGVPLGEAVRTNTMRI 497
Cdd:TIGR01064 450 GDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
2-373 |
1.96e-170 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 484.18 E-value: 1.96e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQ 81
Cdd:pfam00224 1 LRRTKIVCTIGPASN---------------------SVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 82 KVGFLLDTKGPEIRTELFEGDAKEYSYKTGEKIRVATKQGIKSTRD--VIALNVAGaldIYDDVEVGHQVLVDDGKLGLR 159
Cdd:pfam00224 60 TVAIALDTKGPEIRTGNTKDGKKDIELKAGDEMIVSTDAKYKGACDdeMIYVDYKN---IVKDVSVGGTILVDDGLLSLK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 160 VFSKDDATReFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETG 239
Cdd:pfam00224 137 VLSKDDDKT-LVVEVLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 240 NgHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRAT 319
Cdd:pfam00224 216 K-NIQIIAKIENQEGVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPT 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488985134 320 RSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRL 373
Cdd:pfam00224 295 RAEVSDVANAVLDGTDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-501 |
4.15e-169 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 489.82 E-value: 4.15e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:PRK06354 6 LMRRTKIVATIGPASE---------------------SPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLG 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEGDAKEYsyKTGEKIRVATKQgIKSTRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:PRK06354 65 KTVGILQDLQGPKIRLGRFEDGPIEL--KTGDEFILTSRE-VLGTQEKFSVTYDG---LADEVPVGSRILLDDGLIELEV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDATREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:PRK06354 139 EEVDKADGELHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PRK06354 219 KHIPIIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTR 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRLTTDNFERNSKTEVMASAVKDATNSMDI 400
Cdd:PRK06354 299 AEASDVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDA 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 401 KLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIVI 480
Cdd:PRK06354 379 AAIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVI 458
|
490 500
....*....|....*....|.
gi 488985134 481 VAGVPLGEAVRTNTMRIRTVR 501
Cdd:PRK06354 459 TAGTLVGESGSTDLMKVHVVG 479
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
3-497 |
1.08e-158 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 459.13 E-value: 1.08e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 3 KRVKIVATLGPAVEirggkkfgddgywgekldveaSAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:PRK09206 2 KKTKIVCTIGPKTE---------------------SEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKK 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 VGFLLDTKGPEIRTELFEGdAKEYSYKTGEKIRVATKQGIKSTRDVIALNVAGaldIYDDVEVGHQVLVDDGKLGLRVfs 162
Cdd:PRK09206 61 AAILLDTKGPEIRTMKLEG-GNDVSLKAGQTFTFTTDKSVVGNKERVAVTYEG---FTADLSVGNTVLVDDGLIGMEV-- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 163 kdDATREFEVV--VENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:PRK09206 135 --TAITGNEVIckVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PRK09206 213 ENIQIISKIENQEGLNNFDEILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATI-DKNAQTLLNEYGRLTTDNfeRNSKTEVMASAVKDATNSMD 399
Cdd:PRK09206 293 AEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATIcERTDRVMNSRLESNNDNR--KLRITEAVCRGAVETAEKLD 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 400 IKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIV 479
Cdd:PRK09206 371 APLIVVATQGGKSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVV 450
|
490 500
....*....|....*....|
gi 488985134 480 IVAG--VPLGEavrTNTMRI 497
Cdd:PRK09206 451 MVSGalVPSGT---TNTASV 467
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-500 |
1.05e-143 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 420.87 E-value: 1.05e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 1 MNKRVKIVATLGPAVeirggkkfgddgywgekldveASAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG 80
Cdd:PRK06247 3 RNRRVKILATLGPAS---------------------SSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETG 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFeGDAKEYsYKTGEKIRVaTKQGIKSTRDVIALNVAgalDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:PRK06247 62 RPIGILADLQGPKLRLGRF-ADGKVQ-LANGQTFRL-DVDDAPGDHDRVSLPHP---EIAAALKPGDRLLVDDGKVRLVV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDATREFEVVveNDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICeetgN 240
Cdd:PRK06247 136 EACDGDDVVCRVV--EGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII----G 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PRK06247 210 GRVPVMAKIEKPQAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTR 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATI------DKNAQTLLNeYGRLTTdnfeRNSKTEVMASAVKDA 394
Cdd:PRK06247 290 AEVSDVATAVLDGADAVMLSAETASGKYPVEAVRTMARIirqverDPTYPPLIH-AQRPQP----EATKRDAISYAARDI 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 395 TNSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVES 474
Cdd:PRK06247 365 AERLDLAALVAYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKR 444
|
490 500
....*....|....*....|....*.
gi 488985134 475 GDDIVIVAGVPLGEAVRTNTMRIRTV 500
Cdd:PRK06247 445 GDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-500 |
3.40e-121 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 364.85 E-value: 3.40e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPAVEirggkkfgddgywgeklDVEAsaqnIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRA-EEIAG 80
Cdd:PTZ00066 37 QKKTHIVCTMGPACK-----------------NVET----LVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAaKARPN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 81 QKVGFLLDTKGPEIRTELFEgDAKEYSYKTGEKIRVATKQGIKSTRDVIALNVaGALDiyDDVEVGHQVLVDDGKLGLRV 160
Cdd:PTZ00066 96 ANLGILLDTKGPEIRTGFLK-NHKPITLKEGQTLKITTDYTFLGDETCISCSY-KKLP--QSVKVGNIILIADGSLSCKV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDatREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDI-RFGLEQGINFIAISFVRTAKDVDEVRAICEETG 239
Cdd:PTZ00066 172 LEVHD--DYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGERG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 240 NgHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRAT 319
Cdd:PTZ00066 250 R-HIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPT 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 320 RSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNE---YGRLTTDNFERNSKTEVMASAVKDATN 396
Cdd:PTZ00066 329 RAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYrvlYHAIHLAVPTPVSVQEAVARSAVETAE 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 397 SMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGD 476
Cdd:PTZ00066 409 DINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGD 488
|
490 500
....*....|....*....|....
gi 488985134 477 DIVIVAGVPLGEAVRTNTMRIRTV 500
Cdd:PTZ00066 489 SAIAVHGVKEEVAGSSNLMKVVKI 512
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-479 |
2.15e-115 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 349.66 E-value: 2.15e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 2 NKRVKIVATLGPaveirggkkfgddgywgekldVEASAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQ 81
Cdd:PLN02461 20 RPKTKIVCTLGP---------------------ASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 82 KVGFLLDTKGPEIRTElFEGDAKEYSYKTGEKIRVATKQGIKSTRDVIALNVAgalDIYDDVEVGHQVLVDDGKLGLRVF 161
Cdd:PLN02461 79 LCAVMLDTKGPEIRTG-FLKDGKPVQLKQGQEITITTDYSIKGDENMIAMSYK---KLAVDVKPGSVILCADGTITLTVL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 162 SKDDATREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDI-RFGLEQGINFIAISFVRTAKDVDEVRAICEETGN 240
Cdd:PLN02461 155 SCDVEAGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 gHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PLN02461 235 -SILLISKVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNeYGRLTTDNFERN----SKTEVMA-SAVKDAt 395
Cdd:PLN02461 314 AEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLD-YGALFKEIMRSAplpmSPLESLAsSAVRTA- 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 396 NSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQ-------------RGLMLNWGVIPVTTETPS------NTD 456
Cdd:PLN02461 392 NKVKASLIVVLTRGGTTARLVAKYRPAVPILSVVVPEITTdsfdwscsdeapaRHSLIYRGLIPVLAEGSAkatdseSTE 471
|
490 500
....*....|....*....|...
gi 488985134 457 DMFEIAEKIAVEQGLVESGDDIV 479
Cdd:PLN02461 472 EILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
54-481 |
3.93e-102 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 313.91 E-value: 3.93e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 54 RFNFSHGDHAEQGERMATVKRAEEIAGQKVGFLLDTKGPEIRTELFEGDakEYSYKTGEKIRVATKQGI--KSTRDVIAL 131
Cdd:PTZ00300 5 RMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGG--EAVMERGATCYVTTDPAFadKGTKDKFYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 132 NVAgalDIYDDVEVGHQVLVDDGKLGLRVFSKDDAtREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLE 211
Cdd:PTZ00300 83 DYQ---NLSKVVRPGGYIYIDDGILILHVQSHEDE-QTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 212 QGINFIAISFVRTAKDVDEVRAICEETGnGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMI 291
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKG-GDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 292 ITKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYG 371
Cdd:PTZ00300 238 ISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 372 RLTTDNFERN---SKTEVMASAVKDATNSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVT 448
Cdd:PTZ00300 318 FFNSIKKLQPipmSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVF 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 488985134 449 TETP-----SNTDDMFEIAEKIAVEQGLVESGDDIVIV 481
Cdd:PTZ00300 398 FDAErlghdEGKEQRVAMGVGFAKSKGYVQSGDLMVVV 435
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
3-501 |
4.90e-94 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 296.84 E-value: 4.90e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 3 KRVKIVATLGPAVEIRggkkfgddgywgekldveasaQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:PLN02623 110 RKTKIVCTIGPSTNTR---------------------EMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDN 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 V-GFLLDTKGPEIRTelfeGDAKE-YSYKTGEKIRVATKQGIkSTRDVIALNVAgalDIYDDVEVGHQVLVDDGKLGLRV 160
Cdd:PLN02623 169 ViAIMLDTKGPEVRS----GDLPQpIMLEEGQEFTFTIKRGV-STEDCVSVNYD---DFVNDVEVGDMLLVDGGMMSLAV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 161 FSKDDATREFEVVveNDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETgN 240
Cdd:PLN02623 241 KSKTSDSVKCEVV--DGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSC-N 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 241 GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR 320
Cdd:PLN02623 318 ADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTR 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 321 SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATID-KNAQTLLNEYGRLTTDNFERNSKTEVMASAVKDATNSMD 399
Cdd:PLN02623 398 AEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVAlRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLG 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 400 IKLVVtLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIV 479
Cdd:PLN02623 478 TSIIV-FTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVA 556
|
490 500
....*....|....*....|....
gi 488985134 480 IV-AGV-PLGEAVRTNTMRIRTVR 501
Cdd:PLN02623 557 LVqSGRqPIWRSESTHHIQVRKVQ 580
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
40-369 |
1.63e-76 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 244.08 E-value: 1.63e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 40 QNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEiagqKVGFLLDTKGPEIRteLFEGDAKEYSYKTGEKIRVATK 119
Cdd:PRK06739 17 ETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIR--LGEIKGEQITLQAGDSFILHTQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 120 QgikstrdVIALNVAGALD---IYDDVEVGHQVLVDDGKLGLRVfsKDDATREFEVVVENDGIIAKQKGVNIPNTKIPFP 196
Cdd:PRK06739 91 P-------VTGSSTEASVDyegIANDVKVGSRILMNDGEVELIV--EKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 197 ALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG 276
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIARGDLG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 277 IEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTM 356
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVSTL 321
|
330
....*....|...
gi 488985134 357 ATIDKNAQTLLNE 369
Cdd:PRK06739 322 RLVSEFAEHVKKD 334
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
6-480 |
1.44e-73 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 241.88 E-value: 1.44e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 6 KIVATLGP---AVEIrggkkfgddgywgekldveasaqnIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:PLN02765 31 KIVGTLGPksrSVEV------------------------IEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 VGFLLDTKGPEI----RTElfegdaKEYSYKTGEKIRVATKQGIKSTRDVIALNVAG---ALDIYDDVEVGhQVLVDdGK 155
Cdd:PLN02765 87 CAVMLDTVGPELqvinKTE------KPISLKAGNTVTLTPDQSKEASSEVLPINFPGlakAVKPGDTIFVG-QYLFT-GS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 156 LGLRVFSKDDATREFEVV--VENDGIIAkqkG----VNIPNTKIPFPALAERDNDDIR-FGLEQGINFIAISFVRTAKDV 228
Cdd:PLN02765 159 ETTSVWLEVDEVKGDDVVctVKNSATLA---GslftLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 229 DEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITaTNM 308
Cdd:PLN02765 236 REAREFLSSLGLSQTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 309 LETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNE---YGRLTTDNFERNSKTE 385
Cdd:PLN02765 315 VDSMTDNLRPTRAEATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQdlyFKKTVKYVGEPMSHLE 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 386 VMAS-AVKDATNsMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQ-------------RGLMLNWGVIPV---T 448
Cdd:PLN02765 395 SIASsAVRAAIK-VKASVIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKTnqlkwsftgafqaRQCLIVRGLFPMladP 473
|
490 500 510
....*....|....*....|....*....|....*.
gi 488985134 449 TETPSNTDDMFEIAEKIAVEQ----GLVESGDDIVI 480
Cdd:PLN02765 474 RHSAESTSATNESVLKVALDHgkaaGVIKSHDRVVV 509
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
3-482 |
2.27e-70 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 233.10 E-value: 2.27e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 3 KRVKIVATLGPAVeirggkkfgddgywgekldveASAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAGQK 82
Cdd:PLN02762 25 RRTKLVCTIGPAC---------------------CGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 83 VGFLLDTKGPEIRTELFEGDAkeySYKTGE-KIRVATKQGIKSTRDVIALNVAgaldiYD----DVEVGHQVLVDDGKLg 157
Cdd:PLN02762 84 VAVMMDTEGSEIHMGDLGGAS---SAKAEDgEEWTFTVRKFDGSRPEFTIQVN-----YDgfaeDVKVGDELVVDGGMV- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 158 lrvfskddatrEFEVVvENDGIIAKQK----GVNIPNTKIPF--------------PALAERDNDDIRFGLEQGINFIAI 219
Cdd:PLN02762 155 -----------RFEVI-EKIGPDVKCKctdpGLLLPRANLTFwrdgslvrernamlPTISSKDWLDIDFGISEGVDFIAV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 220 SFVRTAKDVDEVRA-ICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAA 298
Cdd:PLN02762 223 SFVKSAEVIKHLKSyIAARSRDSDIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 299 GKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGR------ 372
Cdd:PLN02762 303 NKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRhealel 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 373 --LTTDNFERNSKtEVMASAVKDAtNSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTE 450
Cdd:PLN02762 383 pqLSSSLSDRISE-EICNSAAKMA-NNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD 460
|
490 500 510
....*....|....*....|....*....|..
gi 488985134 451 TPSNTDDMFEIAEKIAVEQGLVESGDDIVIVA 482
Cdd:PLN02762 461 FSDDMESNLNKTFSLLKARGMIKSGDLVIAVS 492
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
294-500 |
9.99e-55 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 186.26 E-value: 9.99e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 294 KVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATI-DKNAQTLLNEYGR 372
Cdd:COG3848 1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIaERAEEDLEYREQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 373 LTTDNFERNSKTEVMASAVKDATNSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETP 452
Cdd:COG3848 81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 488985134 453 SNTDDMFEIAEKIAVEQGLVESGDDIVIVAGVPLGEAVRTNTMRIRTV 500
Cdd:COG3848 161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVV 208
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
42-359 |
2.73e-47 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 170.97 E-value: 2.73e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 42 IAKLIEAGANTFRFNFSHgDHAEQGERM-ATVKRAEEIAGQKVGFLLDTKGPEIRTE-LFEGDAKEYSYkTGEKIRVATK 119
Cdd:PRK08187 152 VLRLAERGMDCARINCAH-DDPAAWQAMiGHLRQAERATGRRCKILMDLAGPKIRTGaVAGPLGKTRLY-TGDRLALVAQ 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 120 QGIKSTRDVIALNVAGALDIYDDVEVGHQVLVDDGKLGLRVFSKDDATREFEV--VVENDGIIAKQKGVNIPNTKIPFPA 197
Cdd:PRK08187 230 GPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVthARPKGLKLKPEKGLNFPDTALDLPA 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 198 LAERDNDDIRFGLEQGiNFIAISFVRTAKDVDEVRAICEETGNG---HVQLFAKIENQQGIDNLDEIIEAADG-----IM 269
Cdd:PRK08187 310 LTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDdwrKLGLVLKIETPRAVANLPELIVQAAGrqpfgVM 388
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 270 IARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATRSEVSDVfnAVIDGTDATMLSgesaNGKYP 349
Cdd:PRK08187 389 IARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDA--AMAARAECVMLN----KGPYL 462
|
330
....*....|
gi 488985134 350 LESVTTMATI 359
Cdd:PRK08187 463 VEAVTFLDDL 472
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
385-497 |
5.94e-43 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 148.01 E-value: 5.94e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 385 EVMASAVKDATNSMDIKLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEK 464
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 488985134 465 IAVEQGLVESGDDIVIVAGVPLGEAVRTNTMRI 497
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
141-359 |
7.87e-35 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 137.77 E-value: 7.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 141 DDVEVGHQVLVDDGKLGLRVfsKDDATREFEVVVENDGI----IAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGiNF 216
Cdd:PRK14725 371 RAARVGERVWFDDGKIGAVV--VKVEADEVELRITHARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DI 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488985134 217 IAISFVRTAKDVDEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAA-----DGIMIARGDMGIEVPFEMVPVYQKMI 291
Cdd:PRK14725 448 VALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILLEAmrhprFGVMIARGDLAVEVGFERLAEVQEEI 527
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488985134 292 ITKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVidGTDATMLSgesaNGKYPLESVTTMATI 359
Cdd:PRK14725 528 LWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMAL--RAECVMLN----KGPHIVEAVRVLDDI 589
|
|
| HpcH_HpaI |
pfam03328 |
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ... |
210-271 |
7.04e-04 |
|
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.
Pssm-ID: 427247 [Multi-domain] Cd Length: 221 Bit Score: 41.19 E-value: 7.04e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488985134 210 LEQGINFIAISFVRTAKDVDEVRAICEE------TGNGHVQLFAKIENQQGIDNLDEIIeAADGIMIA 271
Cdd:pfam03328 81 LDLGAQVVLVPKVETAEDARAAVSAIRYppkgirRANGNTCLLAQIESALGVLNADEIA-AVEGVDGI 147
|
|
| |
