NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488982373|ref|WP_002893189|]
View 

MULTISPECIES: amino acid ABC transporter permease [Klebsiella]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-209 5.60e-52

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 167.17  E-value: 5.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   3 QWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGI 82
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  83 SMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFL 162
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488982373 163 SIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-209 5.60e-52

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 167.17  E-value: 5.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   3 QWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGI 82
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  83 SMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFL 162
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488982373 163 SIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
PRK15100 PRK15100
cystine ABC transporter permease;
17-211 4.21e-25

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 97.90  E-value: 4.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  17 GLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGISMEPWTAGLLALII 96
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIGLSL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  97 YHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAANS 176
Cdd:PRK15100  98 NTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQL 177

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488982373 177 VQATYFIPFNAFIVAIGLYWAISILLELLIKRLTA 211
Cdd:PRK15100 178 ITSRTLEVFTMYLAASLIYWIMATVLSALQNRFEN 212
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-108 2.77e-20

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 81.81  E-value: 2.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   14 FIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGISMEPWTAGLLA 93
Cdd:TIGR01726   5 LLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAAVIA 84

                          90
                  ....*....|....*
gi 488982373   94 LIIYHGAYFFEILRS 108
Cdd:TIGR01726  85 LTLFYGAYLAEIFRG 99
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 18-204 4.76e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.69  E-value: 4.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  18 LFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLG---ISMEPWTAGLLAL 94
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  95 IIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAA 174
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 488982373 175 NSVQATYFIPFNAFIVAIGLYWAISILLEL 204
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-209 2.29e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.14  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   45 YQKKVINRIIIGFVSLMRAIPFLILAYLLYYgLPQLGISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQ 124
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  125 GFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQE-ITAAANSVQATYFIPFN--AFIVAIGLYWAISIL 201
Cdd:pfam00528  90 GASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPgLGLLLIEAILGYDYPEIqgPVLAAALILLLLNLL 169


                  ....*...
gi 488982373  202 LELLIKRL 209
Cdd:pfam00528 170 VDILQRLL 177
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-209 5.60e-52

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 167.17  E-value: 5.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   3 QWGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGI 82
Cdd:COG0765    4 DFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  83 SMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFL 162
Cdd:COG0765   84 DLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLV 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488982373 163 SIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:COG0765  164 SVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
12-221 1.22e-35

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 125.62  E-value: 1.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  12 DSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL----------- 80
Cdd:COG4215   16 PALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQILlnaladlfgyd 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  81 -GISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDT 159
Cdd:COG4215   96 gFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDT 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488982373 160 AFLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRLTAWgAKRGMSHA 221
Cdd:COG4215  176 ALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAALIYLALTTVSELVLARLERR-ASRGVRRA 236
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 4-209 1.46e-34

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 122.51  E-value: 1.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   4 WGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLG-- 81
Cdd:COG4160    3 LDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEwv 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  82 -------ISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLII 154
Cdd:COG4160   83 reswlwpLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVIL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488982373 155 CLKDTAFLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:COG4160  163 MLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLL 217
PRK15100 PRK15100
cystine ABC transporter permease;
17-211 4.21e-25

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 97.90  E-value: 4.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  17 GLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGISMEPWTAGLLALII 96
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMIGLSL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  97 YHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAANS 176
Cdd:PRK15100  98 NTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQL 177

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488982373 177 VQATYFIPFNAFIVAIGLYWAISILLELLIKRLTA 211
Cdd:PRK15100 178 ITSRTLEVFTMYLAASLIYWIMATVLSALQNRFEN 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 4-209 2.27e-21

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 87.80  E-value: 2.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   4 WGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL--G 81
Cdd:PRK09494   5 WSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfnD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  82 ISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAF 161
Cdd:PRK09494  85 LRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSL 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488982373 162 LSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:PRK09494 165 FIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRL 212
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
17-216 4.17e-21

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 87.54  E-value: 4.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  17 GLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLP--------QLG---ISME 85
Cdd:PRK15135  12 GALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQialnsvteALGvgqIDID 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  86 PWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSII 165
Cdd:PRK15135  92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488982373 166 TVQEITAAANSVQATYFIPFNAFIVAIGLYWAISIL---LELLIKRLTAWGAKR 216
Cdd:PRK15135 172 GLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVsngVLLWLERRYSVGVKR 225
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
21-209 4.34e-21

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 87.81  E-value: 4.34e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  21 TLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL-------------------- 80
Cdd:PRK11123  14 TVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQLlltlsdgftlnlgfvqipvq 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  81 ----GISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICL 156
Cdd:PRK11123  94 mdieNFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLL 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488982373 157 KDTAFLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:PRK11123 174 KDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRI 226
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-108 2.77e-20

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 81.81  E-value: 2.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   14 FIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGISMEPWTAGLLA 93
Cdd:TIGR01726   5 LLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAAVIA 84

                          90
                  ....*....|....*
gi 488982373   94 LIIYHGAYFFEILRS 108
Cdd:TIGR01726  85 LTLFYGAYLAEIFRG 99
PRK15069 PRK15069
histidine ABC transporter permease HisM;
91-209 1.13e-14

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 70.46  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  91 LLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEI 170
Cdd:PRK15069 106 ILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDI 185

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488982373 171 TAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:PRK15069 186 LKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRA 224
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 18-204 4.76e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.69  E-value: 4.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  18 LFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLG---ISMEPWTAGLLAL 94
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  95 IIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQEITAAA 174
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 488982373 175 NSVQATYFIPFNAFIVAIGLYWAISILLEL 204
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
artM PRK11122
arginine ABC transporter permease ArtM;
17-209 5.51e-10

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 57.28  E-value: 5.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  17 GLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQL----------GISMEP 86
Cdd:PRK11122  11 GLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFpwlqeypwlwHLLSQP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  87 WTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFrRIILPNIVSSALPLIGNQLIICLKDTAFLSIIT 166
Cdd:PRK11122  91 WLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKSTSLAYTIT 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488982373 167 VQEITAAANSVQA-TYFIpfNAFIVAIGLYWAISILLELLIKRL 209
Cdd:PRK11122 170 LMDVMGYSQLLYGrTYDV--MVFGAAGIIYLVVNGLLTLLMRLI 211
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 6-142 7.26e-09

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   6 VIWSVRDSFIAGLFATLelfitaalAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLyygLPQLGISMe 85
Cdd:COG1173   74 LLYGARISLLVGLLAVL--------IALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIAL---VAVLGPGL- 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488982373  86 pWTAgLLALIIYHGAYFFEILRSQ-RRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVS 142
Cdd:COG1173  142 -LNV-ILALGLTGWPGYARLVRAQvLSLREREYVEAARALGASPLRIIFRHILPNVLP 197
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
4-209 1.16e-08

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 53.29  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   4 WGVIWSVRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPF---LILAYLLYYGLPQL 80
Cdd:PRK15107   6 WSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLvmvLLWFYLIVPGFLQN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  81 GISMEPWT-----AGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGNQLIIC 155
Cdd:PRK15107  86 VLGLSPKTdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVL 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488982373 156 LKDTAFLSIITVQEITAAANSVQATYFIPFNAFIVAIGLYWAISILLELLIKRL 209
Cdd:PRK15107 166 FQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYL 219
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 9-152 2.85e-08

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 52.76  E-value: 2.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   9 SVRDSFIAGLFATLELFITAALAALIIGIALCYFSE-YQKKVINRIIIGFVSLMRAIPF----LILAYLLYYGLPQLGIS 83
Cdd:COG0601   86 PVSDLIAERLPVTLELALLALLLALLIGIPLGILAAlRRGSWLDRLITVLALLGISIPSfwlgLLLILLFAVKLGWLPVS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  84 --MEPWTAGL----------LALIIYHGAYFFEILRSQ-RRVFSGGYIEAAIAQGFSRYAIFRRIILPNIVSSALPLIGN 150
Cdd:COG0601  166 grVSPWEDFLdalrhlilpaLTLALGSLAGIARLTRSSmLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVVTVLGL 245


                 ..
gi 488982373 151 QL 152
Cdd:COG0601  246 QL 247
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-209 2.29e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.14  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   45 YQKKVINRIIIGFVSLMRAIPFLILAYLLYYgLPQLGISMEPWTAGLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQ 124
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373  125 GFSRYAIFRRIILPNIVSSALPLIGNQLIICLKDTAFLSIITVQE-ITAAANSVQATYFIPFN--AFIVAIGLYWAISIL 201
Cdd:pfam00528  90 GASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPgLGLLLIEAILGYDYPEIqgPVLAAALILLLLNLL 169


                  ....*...
gi 488982373  202 LELLIKRL 209
Cdd:pfam00528 170 VDILQRLL 177
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 4-140 1.33e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 38.94  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488982373   4 WGVIWSvRDSFIAGLFATLELFITAALAALIIGIALCYFSEYQKKVINRIIIGFVSLMRAIPFLILAYLLYYGLPQLGIS 83
Cdd:COG1177   50 YAELFS-DPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLS 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488982373  84 MEPWTAgLLALIIYHGAYFFEILRSQRRVFSGGYIEAAIAQGFSRYAIFRRIILPNI 140
Cdd:COG1177  129 GGLWGL-ILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLI 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH