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Conserved domains on  [gi|488942878|ref|WP_002853953|]
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MULTISPECIES: 50S ribosomal protein L11 methyltransferase [Campylobacter]

Protein Classification

50S ribosomal protein L11 methyltransferase( domain architecture ID 11478841)

50S ribosomal protein L11 methyltransferase is a class I SAM-dependent methyltransferase that methylates ribosomal protein L11 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|17215866|18611379|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
3-278 3.07e-82

50S ribosomal protein L11 methyltransferase;


:

Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 247.76  E-value: 3.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   3 KKYYELFFIVEERYKNLFLDFAFDLGIEAIEEkdngvyirsheslEDLSWALEIFAQKLTTTfnlnhkiisnlslvEKEN 82
Cdd:PRK00517   1 MKWIELTLNTTPEAAEALSDILMELGALAALA-------------NLAGLGLDLGEPTYTIE--------------EVED 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  83 KDWIQEYKKGIKPILV-DNVYIHTTWQEEK-KNCINIKINPALAFGSGHHESTYSCVKFLQKFSKSKLRALDLGCGSGIL 160
Cdd:PRK00517  54 EDWEREWKKYFHPIRIgDRLWIVPSWEDPPdPDEINIELDPGMAFGTGTHPTTRLCLEALEKLVLPGKTVLDVGCGSGIL 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 161 GIIMAKFGCN-VEICDTDELAIDSSLENARLNGVDFYKAwcgsIDKANGLYNLIVANIIADVILILEKDIKNHLEDNAIL 239
Cdd:PRK00517 134 AIAAAKLGAKkVLAVDIDPQAVEAARENAELNGVELNVY----LPQGDLKADVIVANILANPLLELAPDLARLLKPGGRL 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 488942878 240 ILSGILDKYSTRIKEKFQD--LELIDEMQINEWCSFVYKNN 278
Cdd:PRK00517 210 ILSGILEEQADEVLEAYEEagFTLDEVLERGEWVALVGKKK 250
 
Name Accession Description Interval E-value
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
3-278 3.07e-82

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 247.76  E-value: 3.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   3 KKYYELFFIVEERYKNLFLDFAFDLGIEAIEEkdngvyirsheslEDLSWALEIFAQKLTTTfnlnhkiisnlslvEKEN 82
Cdd:PRK00517   1 MKWIELTLNTTPEAAEALSDILMELGALAALA-------------NLAGLGLDLGEPTYTIE--------------EVED 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  83 KDWIQEYKKGIKPILV-DNVYIHTTWQEEK-KNCINIKINPALAFGSGHHESTYSCVKFLQKFSKSKLRALDLGCGSGIL 160
Cdd:PRK00517  54 EDWEREWKKYFHPIRIgDRLWIVPSWEDPPdPDEINIELDPGMAFGTGTHPTTRLCLEALEKLVLPGKTVLDVGCGSGIL 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 161 GIIMAKFGCN-VEICDTDELAIDSSLENARLNGVDFYKAwcgsIDKANGLYNLIVANIIADVILILEKDIKNHLEDNAIL 239
Cdd:PRK00517 134 AIAAAKLGAKkVLAVDIDPQAVEAARENAELNGVELNVY----LPQGDLKADVIVANILANPLLELAPDLARLLKPGGRL 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 488942878 240 ILSGILDKYSTRIKEKFQD--LELIDEMQINEWCSFVYKNN 278
Cdd:PRK00517 210 ILSGILEEQADEVLEAYEEagFTLDEVLERGEWVALVGKKK 250
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
4-279 2.16e-74

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 228.90  E-value: 2.16e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   4 KYYELFFIVEERYKNLFLDFAFDLGIEAIEEKDNG----------VYIRSHESLEDLSWALEIFAQKLTttfnlnhkiIS 73
Cdd:COG2264    2 KWIELTITTPEEAAEALSDALEELGAEGVEIEDAPpglwervgvkAYFPEDEDLEELLAALAEALGELG---------AP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  74 NLSLVEKENKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQKFSKSKLRA 150
Cdd:COG2264   73 EITVEEVEEEDWVEEWKKYFKPIRVgDRLVIVPSWEEyePDPGEIVIEIDPGMAFGTGTHPTTRLCLEALEKLLKPGKTV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 151 LDLGCGSGILGIIMAKFG-CNVEICDTDELAIDSSLENARLNGV-DFYKAWCGSIDKaNGLYNLIVANIIADVILILEKD 228
Cdd:COG2264  153 LDVGCGSGILAIAAAKLGaKRVLAVDIDPVAVEAARENAELNGVeDRIEVVLGDLLE-DGPYDLVVANILANPLIELAPD 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488942878 229 IKNHLEDNAILILSGILDKYSTRIKEKF--QDLELIDEMQINEWCSFVYKNNK 279
Cdd:COG2264  232 LAALLKPGGYLILSGILEEQADEVLAAYeaAGFELVERRERGEWVALVLRKKA 284
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 4-276 3.97e-45

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 153.96  E-value: 3.97e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878    4 KYYELFFIV----EERYKNLFLDF-AFDLGIE-AIEEKDNGVYIRSHESlEDLSWALEIFAQKLTTTF------NLNHKI 71
Cdd:pfam06325   1 TWLELSIHTtreaAEPVSNILEEFgALGVAIEdADLLEDRDIFEPGLGE-ERLWDEVRVKALFDEETDaleliaQLAELI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   72 IS----NLSLVEKENKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQKFS 144
Cdd:pfam06325  80 GGldspKVTVEEVAEEDWARAWKKYFHPVRIgERLTIVPSWEDypENPDALNIELDPGMAFGTGTHPTTKLCLEALERLV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  145 KSKLRALDLGCGSGILGIIMAKFGC-NVEICDTDELAIDSSLENARLNGVDFYKAWCGSIDKANGLYNLIVANIIADVIL 223
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEKADVVVANILADPLI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488942878  224 ILEKDIKNHLEDNAILILSGILDKYSTRIKEKF-QDLELIDEMQINEWCSFVYK 276
Cdd:pfam06325 240 ELAPDIYALVKPGGYLILSGILKEQAQMVAEAYsQGFELITVEHREEWVCIVGK 293
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 66-271 6.86e-42

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 145.36  E-value: 6.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   66 NLNHKIISNLSLvekenKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQK 142
Cdd:TIGR00406  81 GRNHKIEFDEFS-----KDWERAWKDNFHPVQFgKRFWICPSWRDvpSDEDALIIMLDPGLAFGTGTHPTTSLCLEWLED 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  143 FSKSKLRALDLGCGSGILGIIMAKFGC-NVEICDTDELAIDSSLENARLNGV--DFYKAWCGSIDKANGLYNLIVANIIA 219
Cdd:TIGR00406 156 LDLKDKNVIDVGCGSGILSIAALKLGAaKVVGIDIDPLAVESARKNAELNQVsdRLQVKLIYLEQPIEGKADVIVANILA 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488942878  220 DVILILEKDIKNHLEDNAILILSGILDKYSTRIKEKF-QDLELIDEMQINEWC 271
Cdd:TIGR00406 236 EVIKELYPQFSRLVKPGGWLILSGILETQAQSVCDAYeQGFTVVEIRQREEWC 288
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-242 7.07e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.26  E-value: 7.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 149 RALDLGCGSGILGIIMAKF-GCNVEICDTDELAIDSSLENARL---NGVDFYKA-WCGSIDKANGLYNLIVAN-----II 218
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAAllaDNVEVLKGdAEELPPEADESFDVIISDpplhhLV 80

                         90       100
                 ....*....|....*....|....
gi 488942878 219 ADVILILEKdIKNHLEDNAILILS 242
Cdd:cd02440   81 EDLARFLEE-ARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
3-278 3.07e-82

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 247.76  E-value: 3.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   3 KKYYELFFIVEERYKNLFLDFAFDLGIEAIEEkdngvyirsheslEDLSWALEIFAQKLTTTfnlnhkiisnlslvEKEN 82
Cdd:PRK00517   1 MKWIELTLNTTPEAAEALSDILMELGALAALA-------------NLAGLGLDLGEPTYTIE--------------EVED 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  83 KDWIQEYKKGIKPILV-DNVYIHTTWQEEK-KNCINIKINPALAFGSGHHESTYSCVKFLQKFSKSKLRALDLGCGSGIL 160
Cdd:PRK00517  54 EDWEREWKKYFHPIRIgDRLWIVPSWEDPPdPDEINIELDPGMAFGTGTHPTTRLCLEALEKLVLPGKTVLDVGCGSGIL 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 161 GIIMAKFGCN-VEICDTDELAIDSSLENARLNGVDFYKAwcgsIDKANGLYNLIVANIIADVILILEKDIKNHLEDNAIL 239
Cdd:PRK00517 134 AIAAAKLGAKkVLAVDIDPQAVEAARENAELNGVELNVY----LPQGDLKADVIVANILANPLLELAPDLARLLKPGGRL 209

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 488942878 240 ILSGILDKYSTRIKEKFQD--LELIDEMQINEWCSFVYKNN 278
Cdd:PRK00517 210 ILSGILEEQADEVLEAYEEagFTLDEVLERGEWVALVGKKK 250
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
4-279 2.16e-74

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 228.90  E-value: 2.16e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   4 KYYELFFIVEERYKNLFLDFAFDLGIEAIEEKDNG----------VYIRSHESLEDLSWALEIFAQKLTttfnlnhkiIS 73
Cdd:COG2264    2 KWIELTITTPEEAAEALSDALEELGAEGVEIEDAPpglwervgvkAYFPEDEDLEELLAALAEALGELG---------AP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  74 NLSLVEKENKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQKFSKSKLRA 150
Cdd:COG2264   73 EITVEEVEEEDWVEEWKKYFKPIRVgDRLVIVPSWEEyePDPGEIVIEIDPGMAFGTGTHPTTRLCLEALEKLLKPGKTV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 151 LDLGCGSGILGIIMAKFG-CNVEICDTDELAIDSSLENARLNGV-DFYKAWCGSIDKaNGLYNLIVANIIADVILILEKD 228
Cdd:COG2264  153 LDVGCGSGILAIAAAKLGaKRVLAVDIDPVAVEAARENAELNGVeDRIEVVLGDLLE-DGPYDLVVANILANPLIELAPD 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488942878 229 IKNHLEDNAILILSGILDKYSTRIKEKF--QDLELIDEMQINEWCSFVYKNNK 279
Cdd:COG2264  232 LAALLKPGGYLILSGILEEQADEVLAAYeaAGFELVERRERGEWVALVLRKKA 284
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 4-276 3.97e-45

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 153.96  E-value: 3.97e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878    4 KYYELFFIV----EERYKNLFLDF-AFDLGIE-AIEEKDNGVYIRSHESlEDLSWALEIFAQKLTTTF------NLNHKI 71
Cdd:pfam06325   1 TWLELSIHTtreaAEPVSNILEEFgALGVAIEdADLLEDRDIFEPGLGE-ERLWDEVRVKALFDEETDaleliaQLAELI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   72 IS----NLSLVEKENKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQKFS 144
Cdd:pfam06325  80 GGldspKVTVEEVAEEDWARAWKKYFHPVRIgERLTIVPSWEDypENPDALNIELDPGMAFGTGTHPTTKLCLEALERLV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  145 KSKLRALDLGCGSGILGIIMAKFGC-NVEICDTDELAIDSSLENARLNGVDFYKAWCGSIDKANGLYNLIVANIIADVIL 223
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEKADVVVANILADPLI 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488942878  224 ILEKDIKNHLEDNAILILSGILDKYSTRIKEKF-QDLELIDEMQINEWCSFVYK 276
Cdd:pfam06325 240 ELAPDIYALVKPGGYLILSGILKEQAQMVAEAYsQGFELITVEHREEWVCIVGK 293
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 66-271 6.86e-42

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 145.36  E-value: 6.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878   66 NLNHKIISNLSLvekenKDWIQEYKKGIKPILV-DNVYIHTTWQE--EKKNCINIKINPALAFGSGHHESTYSCVKFLQK 142
Cdd:TIGR00406  81 GRNHKIEFDEFS-----KDWERAWKDNFHPVQFgKRFWICPSWRDvpSDEDALIIMLDPGLAFGTGTHPTTSLCLEWLED 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  143 FSKSKLRALDLGCGSGILGIIMAKFGC-NVEICDTDELAIDSSLENARLNGV--DFYKAWCGSIDKANGLYNLIVANIIA 219
Cdd:TIGR00406 156 LDLKDKNVIDVGCGSGILSIAALKLGAaKVVGIDIDPLAVESARKNAELNQVsdRLQVKLIYLEQPIEGKADVIVANILA 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488942878  220 DVILILEKDIKNHLEDNAILILSGILDKYSTRIKEKF-QDLELIDEMQINEWC 271
Cdd:TIGR00406 236 EVIKELYPQFSRLVKPGGWLILSGILETQAQSVCDAYeQGFTVVEIRQREEWC 288
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 138-242 5.70e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 61.57  E-value: 5.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 138 KFLQKFSKSKLRALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGVDFYKAWCGSIDKANGLYNLIVANI 217
Cdd:COG2227   16 ALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVICSE 95

                         90       100
                 ....*....|....*....|....*....
gi 488942878 218 ----IADVILILEKdIKNHLEDNAILILS 242
Cdd:COG2227   96 vlehLPDPAALLRE-LARLLKPGGLLLLS 123
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 149-241 1.01e-11

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 62.51  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNVEI--CDTDELAIDSSLENARLNG---VDFYKAWCGSiDKANGLYNLIVAN------- 216
Cdd:COG2813   52 RVLDLGCGYGVIGLALAKRNPEARVtlVDVNARAVELARANAAANGlenVEVLWSDGLS-GVPDGSFDLILSNppfhagr 130

                         90       100
                 ....*....|....*....|....*.
gi 488942878 217 -IIADVILILEKDIKNHLEDNAILIL 241
Cdd:COG2813  131 aVDKEVAHALIADAARHLRPGGELWL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 149-262 2.08e-11

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 61.07  E-value: 2.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  149 RALDLGCGSGILGIIMAKFGCNVEI--CDTDELAIDSSLENARLNGVDFYKAWCGSI--DKANGLYNLIVAN-------- 216
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESPDAELtmVDINARALESARENLAANGLENGEVVASDVysGVEDGKFDLIISNppfhagla 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 488942878  217 IIADVILILEKDIKNHLEDNAILIL---SGIldKYSTRIKEKFQDLELI 262
Cdd:pfam05175 114 TTYNVAQRFIADAKRHLRPGGELWIvanRFL--GYPPLLEELFGNVEVV 160
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 149-221 7.86e-11

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 60.28  E-value: 7.86e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488942878 149 RALDLGCGSGILGIIMAKFG-CNVEICDTDELAIDSSLENARLNGVDFyKAWCGSIDKAN--GLYNLIVAniiADV 221
Cdd:COG3897   73 RVLELGCGLGLVGIAAAKAGaADVTATDYDPEALAALRLNAALNGVAI-TTRLGDWRDPPaaGGFDLILG---GDV 144
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 129-273 3.75e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 54.74  E-value: 3.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  129 HHESTYSCVKFLQKFS---KSKLRALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGVDFYKAWcgsidK 205
Cdd:pfam13489   2 AHQRERLLADLLLRLLpklPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAA-----V 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488942878  206 ANGLYNLIVANI----IADVILILeKDIKNHLEDNAILILSGILdkYSTRIKEKFQDLELIDEMqiNEWCSF 273
Cdd:pfam13489  77 PAGKFDVIVAREvlehVPDPPALL-RQIAALLKPGGLLLLSTPL--ASDEADRLLLEWPYLRPR--NGHISL 143
PRK14968 PRK14968
putative methyltransferase; Provisional
 149-194 1.99e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 52.98  E-value: 1.99e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGVD 194
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIR 71
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
138-242 6.13e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.54  E-value: 6.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 138 KFLQKFSKSK-LRALDLGCGSGILGIIMAKFGCNVeicdtdeLAIDSS---LENARLNGV--DFYKAWCGSIDKANGLYN 211
Cdd:COG4976   37 ELLARLPPGPfGRVLDLGCGTGLLGEALRPRGYRL-------TGVDLSeemLAKAREKGVydRLLVADLADLAEPDGRFD 109

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 488942878 212 LIVAniiADVILILE------KDIKNHLEDNAILILS 242
Cdd:COG4976  110 LIVA---ADVLTYLGdlaavfAGVARALKPGGLFIFS 143
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 145-232 1.63e-07

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 50.93  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  145 KSKLRALDLGCGSGILGIIMAKF--GCNVEICDTDELAIDSSLENARLNG---VDFYKA-WCGSIDkaNGLYNLIVAN-- 216
Cdd:TIGR03534  85 KKGPRVLDLGTGSGAIALALAKErpDARVTAVDISPEALAVARKNARRLGlenVEFLQGdWFEPLP--SGKFDLIVSNpp 162

                          90
                  ....*....|....*..
gi 488942878  217 -IIADVILILEKDIKNH 232
Cdd:TIGR03534 163 yIPEADIHLLDPEVRDF 179
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 141-232 2.09e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 50.93  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 141 QKFSKSKLRALDLGCGSGILGIIMAKF--GCNVEICDTDELAIDSSLENARLNG---VDFYKA-WCGSIDkaNGLYNLIV 214
Cdd:PRK09328 103 ALLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALAVARRNAKHGLgarVEFLQGdWFEPLP--GGRFDLIV 180

                         90       100
                 ....*....|....*....|.
gi 488942878 215 AN---IIADVILILEKDIKNH 232
Cdd:PRK09328 181 SNppyIPEADIHLLQPEVRDH 201
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 145-216 2.81e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 50.14  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 145 KSKLRALDLGCGSGILGIIMAKFGCNVEI--CDTDELAIDSSLENARLNGV-DFYKAWCGSI-----DKANGLYNLIVAN 216
Cdd:COG4123   36 KKGGRVLDLGTGTGVIALMLAQRSPGARItgVEIQPEAAELARRNVALNGLeDRITVIHGDLkefaaELPPGSFDLVVSN 115
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 146-232 4.92e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 49.76  E-value: 4.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 146 SKLRALDLGCGSGILGIIMAKF--GCNVEICDTDELAIDSSLENARLNG----VDFYKA-WCGSIdKANGLYNLIVAN-- 216
Cdd:COG2890  112 APPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVARRNAERLGledrVRFLQGdLFEPL-PGDGRFDLIVSNpp 190

                         90
                 ....*....|....*..
gi 488942878 217 -IIADVILILEKDIKNH 232
Cdd:COG2890  191 yIPEDEIALLPPEVRDH 207
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 151-216 6.05e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.71  E-value: 6.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488942878  151 LDLGCGSGILGIIMAK-FGCNVEICDTDELAIDSSLENARLNG--VDFYKAWCGSIDKANGLYNLIVAN 216
Cdd:pfam13649   2 LDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGlnVEFVQGDAEDLPFPDGSFDLVVSS 70
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
149-216 2.90e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 43.74  E-value: 2.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNVEIC-DTDELAIDSSLENARLNG--VDFYKAWCGSIDKaNGLYNLIVAN 216
Cdd:COG2263   48 TVLDLGCGTGMLAIGAALLGAKKVVGvDIDPEALEIARENAERLGvrVDFIRADVTRIPL-GGSVDTVVMN 117
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 149-242 7.07e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.26  E-value: 7.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 149 RALDLGCGSGILGIIMAKF-GCNVEICDTDELAIDSSLENARL---NGVDFYKA-WCGSIDKANGLYNLIVAN-----II 218
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAAllaDNVEVLKGdAEELPPEADESFDVIISDpplhhLV 80

                         90       100
                 ....*....|....*....|....
gi 488942878 219 ADVILILEKdIKNHLEDNAILILS 242
Cdd:cd02440   81 EDLARFLEE-ARRLLKPGGVLVLT 103
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 140-194 8.74e-05

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 43.32  E-value: 8.74e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488942878 140 LQKFSKSKLRALDLGCGSGILGIIMAK-FGCNVEICDTDELAIDSSLENARLNGVD 194
Cdd:COG1867   51 YRERLKREISYLDALAASGIRGLRYALeVGIKVTLNDIDPEAVELIRENLELNGLE 106
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 145-243 1.15e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.21  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 145 KSKLRALDLGCGSGILGIIMAK-FGCNVEICDTDELAID---SSLENARLNGVDFYkawCGSIDKANGL----YNLIVAN 216
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIAlarARAAKAGLGNVEFL---VADLAELDPLpaesFDLVVAF 101

                         90       100       110
                 ....*....|....*....|....*....|..
gi 488942878 217 II-----ADVILILEKDIKNHLEDNAILILSG 243
Cdd:COG0500  102 GVlhhlpPEEREALLRELARALKPGGVLLLSA 133
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
149-242 1.48e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.19  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNVEIcdtdeLAIDSS---LENAR--LNGVDFykaWCGSID--KANGLYNLIVAN----I 217
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGARV-----TGVDLSpemLARARarLPNVRF---VVADLRdlDPPEPFDLVVSNaalhW 75

                         90       100
                 ....*....|....*....|....*
gi 488942878 218 IADVILILEKdIKNHLEDNAILILS 242
Cdd:COG4106   76 LPDHAALLAR-LAAALAPGGVLAVQ 99
PRK06202 PRK06202
hypothetical protein; Provisional
 148-216 2.28e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 41.52  E-value: 2.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488942878 148 LRALDLGCGSGILGIIMAKF----GCNVEI--CDTDELAIDSSLENARLNGVDFYKAWCGSIDKANGLYNLIVAN 216
Cdd:PRK06202  62 LTLLDIGCGGGDLAIDLARWarrdGLRLEVtaIDPDPRAVAFARANPRRPGVTFRQAVSDELVAEGERFDVVTSN 136
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 149-198 3.93e-04

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 41.32  E-value: 3.93e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNV---EIcdtDELAIDSSLENARLNG---VDFYKA 198
Cdd:COG2265  236 RVLDLYCGVGTFALPLARRAKKVigvEI---VPEAVEDARENARLNGlknVEFVAG 288
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-198 1.75e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 36.87  E-value: 1.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 488942878  151 LDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGVDFYKA 198
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVG 48
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
140-193 2.55e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 38.41  E-value: 2.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488942878 140 LQKFSKSKLRALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGV 193
Cdd:PRK11036  38 LAELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGV 91
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 151-239 3.47e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.19  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  151 LDLGCGSGILGIIMAKFGCNVEI--CDTDELAIDSSLEnaRLNGVDFYKAWCGSIDKANGL------YNLIVANI----I 218
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYtgLDISPAALEAARE--RLAALGLLNAVRVELFQLDLGeldpgsFDVVVASNvlhhL 78

                          90       100
                  ....*....|....*....|.
gi 488942878  219 ADVILILEKdIKNHLEDNAIL 239
Cdd:pfam08242  79 ADPRAVLRN-IRRLLKPGGVL 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 145-242 5.60e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.63  E-value: 5.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878  145 KSKLRALDLGCGSGILGIIMA-KFGCNVEIC--DTDELAIDSSLENARLNGVDFYKAWCGSIDK-----ANGLYNLIVA- 215
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAeELGPNAEVVgiDISEEAIEKARENAQKLGFDNVEFEQGDIEElpellEDDKFDVVISn 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 488942878  216 ---NIIADVILILEKdIKNHLEDNAILILS 242
Cdd:pfam13847  82 cvlNHIPDPDKVLQE-ILRVLKPGGRLIIS 110
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 149-216 5.90e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 36.51  E-value: 5.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488942878 149 RALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNG--VDFYKAWCGSIDKANGLYNLIVAN 216
Cdd:COG2226   25 RVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGlnVEFVVGDAEDLPFPDGSFDLVISS 94
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
151-216 8.61e-03

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 37.22  E-value: 8.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488942878 151 LDLGCGSGILGIIMAKFGCNVEI--CDTDELAIDSSLENARLNGVDfykawcGSIDKAN------GLYNLIVAN 216
Cdd:PRK09489 201 LDVGCGAGVLSAVLARHSPKIRLtlSDVSAAALESSRATLAANGLE------GEVFASNvfsdikGRFDMIISN 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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