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Conserved domains on  [gi|488661668|ref|WP_002590576|]
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MULTISPECIES: hypothetical protein [Bacteria]

Protein Classification

transposon-transfer assisting family protein( domain architecture ID 10624705)

transposon-transfer assisting family protein similar to Clostridium difficile CD1104B, which is encoded in transposon CTn4 and may participate in interactions with proteins required for the transfer of transposons between different bacterial species

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TTRAP pfam14203
Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins ...
4-64 7.50e-21

Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins largely from Clostrium difficile. From comparative and other structural studies of the PDB:2L7K, UniProtKB:Q18AW3, it has been suggested that this family is required for interacting with other proteins in order to facilitate the transfer of the transposon CTn4 between different bacterial species. PDB:2L7K comprises an alpha-helical fold of four alpha-helices leading to the production of two clefts, the larger of which displays two highly conserved residues in close proximity, Glu-8 and Lys-48. The gene concerned is part of an operon within transposon CTn4, and is expressed alongside a putative DNA primase, a DNA topoisomerase and conjugal transfer proteins.


:

Pssm-ID: 433771  Cd Length: 62  Bit Score: 76.89  E-value: 7.50e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488661668   4 LTVEETNLLSIYKTGSRQGLIVAMNAALPFM-DGEMRGFAARTLAKVERMGEAEFAELPIYA 64
Cdd:pfam14203  1 FTVEEINLMCIYNEGSRSGLIEELTAMLPYLeDAELRELTDSTLQKLEAMTDAEFAELELYP 62
 
Name Accession Description Interval E-value
TTRAP pfam14203
Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins ...
4-64 7.50e-21

Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins largely from Clostrium difficile. From comparative and other structural studies of the PDB:2L7K, UniProtKB:Q18AW3, it has been suggested that this family is required for interacting with other proteins in order to facilitate the transfer of the transposon CTn4 between different bacterial species. PDB:2L7K comprises an alpha-helical fold of four alpha-helices leading to the production of two clefts, the larger of which displays two highly conserved residues in close proximity, Glu-8 and Lys-48. The gene concerned is part of an operon within transposon CTn4, and is expressed alongside a putative DNA primase, a DNA topoisomerase and conjugal transfer proteins.


Pssm-ID: 433771  Cd Length: 62  Bit Score: 76.89  E-value: 7.50e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488661668   4 LTVEETNLLSIYKTGSRQGLIVAMNAALPFM-DGEMRGFAARTLAKVERMGEAEFAELPIYA 64
Cdd:pfam14203  1 FTVEEINLMCIYNEGSRSGLIEELTAMLPYLeDAELRELTDSTLQKLEAMTDAEFAELELYP 62
 
Name Accession Description Interval E-value
TTRAP pfam14203
Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins ...
4-64 7.50e-21

Putative transposon-transfer assisting protein; TTRAP is a family of small bacterial proteins largely from Clostrium difficile. From comparative and other structural studies of the PDB:2L7K, UniProtKB:Q18AW3, it has been suggested that this family is required for interacting with other proteins in order to facilitate the transfer of the transposon CTn4 between different bacterial species. PDB:2L7K comprises an alpha-helical fold of four alpha-helices leading to the production of two clefts, the larger of which displays two highly conserved residues in close proximity, Glu-8 and Lys-48. The gene concerned is part of an operon within transposon CTn4, and is expressed alongside a putative DNA primase, a DNA topoisomerase and conjugal transfer proteins.


Pssm-ID: 433771  Cd Length: 62  Bit Score: 76.89  E-value: 7.50e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488661668   4 LTVEETNLLSIYKTGSRQGLIVAMNAALPFM-DGEMRGFAARTLAKVERMGEAEFAELPIYA 64
Cdd:pfam14203  1 FTVEEINLMCIYNEGSRSGLIEELTAMLPYLeDAELRELTDSTLQKLEAMTDAEFAELELYP 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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