YhgE/Pip (phage infection protein) domain-containing protein similar to the membrane protein EsaA of the Staphylococcus aureus ESS/Type VII secretion system, Bacillus subtilis ESX secretion system protein YueB, and uncharacterized protein YhgE
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple ...
10-208
2.82e-36
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.
The actual alignment was detected with superfamily member TIGR03929:
Pssm-ID: 354443 [Multi-domain] Cd Length: 193 Bit Score: 135.62 E-value: 2.82e-36
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
143-740
4.79e-04
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
The actual alignment was detected with superfamily member TIGR01612:
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 44.27 E-value: 4.79e-04
type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with ...
10-208
2.82e-36
type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This model represents the conserved N-terminal domain.
Pssm-ID: 274861 [Multi-domain] Cd Length: 193 Bit Score: 135.62 E-value: 2.82e-36
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
143-740
4.79e-04
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 44.27 E-value: 4.79e-04
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic ...
827-996
1.71e-03
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic proteins, with few highly conserved residues, all may act to polymerize the oligosaccharide repeat units of surface polysaccharides, including O-antigen in Gram-negative bacteria such as Leptospira (assign gene symbol wzy) and capsular polysaccharide in Gram-positive bacteria such as Streptococcus. O-antigen biosynthesis enzymes produce a repeat unit, usually an oligosaccharide, which itself is polymerized. O-antigen polymerase, usually designated Wzy. This family bears homology to the O-antigen ligase WaaL, but known examples of WaaL fall outside the bounds defined here. This model is much broader than pfam14296. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 275163 [Multi-domain] Cd Length: 392 Bit Score: 41.76 E-value: 1.71e-03
type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with ...
10-208
2.82e-36
type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This model represents the conserved N-terminal domain.
Pssm-ID: 274861 [Multi-domain] Cd Length: 193 Bit Score: 135.62 E-value: 2.82e-36
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple ...
43-168
2.18e-21
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.
Pssm-ID: 274413 [Multi-domain] Cd Length: 164 Bit Score: 91.88 E-value: 2.18e-21
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
143-740
4.79e-04
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 44.27 E-value: 4.79e-04
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic ...
827-996
1.71e-03
oligosaccharide repeat unit polymerase; Members of this subfamily of highly hydrophobic proteins, with few highly conserved residues, all may act to polymerize the oligosaccharide repeat units of surface polysaccharides, including O-antigen in Gram-negative bacteria such as Leptospira (assign gene symbol wzy) and capsular polysaccharide in Gram-positive bacteria such as Streptococcus. O-antigen biosynthesis enzymes produce a repeat unit, usually an oligosaccharide, which itself is polymerized. O-antigen polymerase, usually designated Wzy. This family bears homology to the O-antigen ligase WaaL, but known examples of WaaL fall outside the bounds defined here. This model is much broader than pfam14296. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 275163 [Multi-domain] Cd Length: 392 Bit Score: 41.76 E-value: 1.71e-03
Colicin V production protein; Colicin V production protein is required in E. Coli for colicin ...
908-1005
5.35e-03
Colicin V production protein; Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30. This protein is coded for in the purF operon.
Pssm-ID: 460647 Cd Length: 143 Bit Score: 38.27 E-value: 5.35e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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