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Conserved domains on  [gi|488409823|ref|WP_002479208|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Staphylococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-148 3.09e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 47.59  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409823  19 ERLLEMSHYGEITIEQIAENTGVSKATIYRRWKDKASIIIDMFVTHTRDI------TFNHINLYDALFAFATQIMAIYKT 92
Cdd:COG1309   16 LELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELlaaleeALAAEDPRERLRALLRAYLEFLAE 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488409823  93 NLGRAVIEILVSSKQSEARGLFmKGYFESNRRNFKEMIA--PYLNEEDQDLMIDLVFS 148
Cdd:COG1309   96 NPALARLLLAEAAELPELRAAL-RALLRRLRALLAELLRagGLLADVDPDALARALLA 152
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-148 3.09e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 47.59  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409823  19 ERLLEMSHYGEITIEQIAENTGVSKATIYRRWKDKASIIIDMFVTHTRDI------TFNHINLYDALFAFATQIMAIYKT 92
Cdd:COG1309   16 LELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELlaaleeALAAEDPRERLRALLRAYLEFLAE 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488409823  93 NLGRAVIEILVSSKQSEARGLFmKGYFESNRRNFKEMIA--PYLNEEDQDLMIDLVFS 148
Cdd:COG1309   96 NPALARLLLAEAAELPELRAAL-RALLRRLRALLAELLRagGLLADVDPDALARALLA 152
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 75-169 1.86e-05

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 41.79  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409823   75 LYDALFAFATQIMAIYKTNLGRAVIEILVSSKQS--EARGLFMKGYFESNRRNFKEM---------IAPylnEEDQDLMI 143
Cdd:pfam16859   7 LRGDLRALLRALARALTSPRGGALLRALIAAAQRdpELAAALRERFLEPRRAALRAVleravargeLRP---DADPDLVL 83

                          90       100
                  ....*....|....*....|....*.
gi 488409823  144 DLVFSPIYFNILIKPQELDEHYIQRL 169
Cdd:pfam16859  84 DLLFGPLYYRLLLTGEPLDEAYADRL 109
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 3-48 9.69e-03

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 32.68  E-value: 9.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488409823   3 GRPkdPTIDKKIFSEIERLLEMshyGEiTIEQIAENTGVSKATIYR 48
Cdd:cd00569    1 GRP--PKLTPEQIAEARRLLAA---GE-SVAEIARELGVSRSTLYR 40
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-148 3.09e-07

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 47.59  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409823  19 ERLLEMSHYGEITIEQIAENTGVSKATIYRRWKDKASIIIDMFVTHTRDI------TFNHINLYDALFAFATQIMAIYKT 92
Cdd:COG1309   16 LELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELlaaleeALAAEDPRERLRALLRAYLEFLAE 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488409823  93 NLGRAVIEILVSSKQSEARGLFmKGYFESNRRNFKEMIA--PYLNEEDQDLMIDLVFS 148
Cdd:COG1309   96 NPALARLLLAEAAELPELRAAL-RALLRRLRALLAELLRagGLLADVDPDALARALLA 152
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 75-169 1.86e-05

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 41.79  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409823   75 LYDALFAFATQIMAIYKTNLGRAVIEILVSSKQS--EARGLFMKGYFESNRRNFKEM---------IAPylnEEDQDLMI 143
Cdd:pfam16859   7 LRGDLRALLRALARALTSPRGGALLRALIAAAQRdpELAAALRERFLEPRRAALRAVleravargeLRP---DADPDLVL 83

                          90       100
                  ....*....|....*....|....*.
gi 488409823  144 DLVFSPIYFNILIKPQELDEHYIQRL 169
Cdd:pfam16859  84 DLLFGPLYYRLLLTGEPLDEAYADRL 109
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
3-53 3.10e-04

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 36.95  E-value: 3.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 488409823    3 GRPkdPTIDKKIFSEIERLLEmshyGEITIEQIAENTGVSKATIYRRWKDK 53
Cdd:pfam02796   1 GRP--PKLNEEDINEVITLLE----EGISIKQIAKIFGISRSTVYRYLAAS 45
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
27-60 3.60e-04

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 36.62  E-value: 3.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 488409823   27 YGEITIEQIAENTGVSKATIYRRWKDKASIIIDM 60
Cdd:pfam00440  14 YDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
Sigma70_ECF pfam07638
ECF sigma factor; These proteins are probably RNA polymerase sigma factors belonging to the ...
 17-50 2.39e-03

ECF sigma factor; These proteins are probably RNA polymerase sigma factors belonging to the extra-cytoplasmic function (ECF) subfamily and show sequence similarity to pfam04542 and pfam04545.


Pssm-ID: 254323 [Multi-domain]  Cd Length: 185  Bit Score: 37.01  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 488409823   17 EIERLLEMSHYGEITIEQIAENTGVSKATIYRRW 50
Cdd:pfam07638 139 RQARLVELRFFAGLSNDEIAERLGVSERTVERNW 172
AlpA COG3311
DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];
30-52 5.42e-03

DNA-binding transcriptional regulator AlpA [Transcription, Mobilome: prophages, transposons];


Pssm-ID: 442540 [Multi-domain]  Cd Length: 64  Bit Score: 34.13  E-value: 5.42e-03
                         10        20
                 ....*....|....*....|...
gi 488409823  30 ITIEQIAENTGVSKATIYRRWKD 52
Cdd:COG3311    9 LRLKEVAELLGVSRSTIYRLIKK 31
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 3-48 9.69e-03

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 32.68  E-value: 9.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 488409823   3 GRPkdPTIDKKIFSEIERLLEMshyGEiTIEQIAENTGVSKATIYR 48
Cdd:cd00569    1 GRP--PKLTPEQIAEARRLLAA---GE-SVAEIARELGVSRSTLYR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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