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Conserved domains on  [gi|488409257|ref|WP_002478642|]
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MULTISPECIES: alpha/beta fold hydrolase [Staphylococcus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 35-290 6.21e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 75.04  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  35 IVFIHGAMMTYRIMAMFEPYFRE-YQMIFVNCPGRGESSeLTTTKDTLDDYSERIYDVLsqvvEQHGIKKMMLLGYSMGG 113
Cdd:COG0596   26 VVLLHGLPGSSYEWRPLIPALAAgYRVIAPDLRGHGRSD-KPAGGYTLDDLADDLAALL----DALGLERVVLVGHSMGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 114 MIATRLLKFNTLPITHLVYLNSAaritpntsmlsrlfsgdskREHLKDEMAAIKNLPQyildktvyaktesakdifsfla 193
Cdd:COG0596  101 MVALELAARHPERVAGLVLVDEV-------------------LAALAEPLRRPGLAPE---------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 194 pvkTILTDIEYSIKADYLPDIEEIEQfPkLLFISGEDDEIIPYTDSHEtllkYQEFGGTAVEVVYPGIGHLdfptvleSQ 273
Cdd:COG0596  140 ---ALAALLRALARTDLRERLARITV-P-TLVIWGEKDPIVPPALARR----LAELLPNAELVVLPGAGHF-------PP 203

                        250
                 ....*....|....*..
gi 488409257 274 EDDTKGIVDQIKAWVAS 290
Cdd:COG0596  204 LEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 35-290 6.21e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 75.04  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  35 IVFIHGAMMTYRIMAMFEPYFRE-YQMIFVNCPGRGESSeLTTTKDTLDDYSERIYDVLsqvvEQHGIKKMMLLGYSMGG 113
Cdd:COG0596   26 VVLLHGLPGSSYEWRPLIPALAAgYRVIAPDLRGHGRSD-KPAGGYTLDDLADDLAALL----DALGLERVVLVGHSMGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 114 MIATRLLKFNTLPITHLVYLNSAaritpntsmlsrlfsgdskREHLKDEMAAIKNLPQyildktvyaktesakdifsfla 193
Cdd:COG0596  101 MVALELAARHPERVAGLVLVDEV-------------------LAALAEPLRRPGLAPE---------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 194 pvkTILTDIEYSIKADYLPDIEEIEQfPkLLFISGEDDEIIPYTDSHEtllkYQEFGGTAVEVVYPGIGHLdfptvleSQ 273
Cdd:COG0596  140 ---ALAALLRALARTDLRERLARITV-P-TLVIWGEKDPIVPPALARR----LAELLPNAELVVLPGAGHF-------PP 203

                        250
                 ....*....|....*..
gi 488409257 274 EDDTKGIVDQIKAWVAS 290
Cdd:COG0596  204 LEQPEAFAAALRDFLAR 220
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-264 1.98e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 59.41  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   35 IVFIHGAmmTYRIMAMFEPYFREYQMIFVNCPGRGESSELTTTKDTLDDYSeriyDVLSQVVEQHGIkkmMLLGYSMGGM 114
Cdd:pfam12697   1 VVLVHGA--GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLA----ALLDELGAARPV---VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  115 IATRLLkfnTLPITHLVYLNSAARITPNTSMLSRLFsgdskrEHLKDEMAAIKNLPQYILDKTVYAKTESAKDIFSFLAP 194
Cdd:pfam12697  72 VALAAA---AAALVVGVLVAPLAAPPGLLAALLALL------ARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALAR 142

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  195 VKTILTDIEYSIKADYlpdieeiEQFPKLLFISGEDDEIIPytdshETLLKYQEFGGTAVEVVYPGIGHL 264
Cdd:pfam12697 143 LAALLAALALLPLAAW-------RDLPVPVLVLAEEDRLVP-----ELAQRLLAALAGARLVVLPGAGHL 200
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 34-119 1.04e-07

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 51.83  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   34 IIVFIHGAMMTYR----IMAMFEPyfrEYQMIFVNCPGRGES-SELTTTKDTLDDYSEriyDVLSQVVEQHGIKKMMLLG 108
Cdd:TIGR03695   4 VLVFLHGFLGSGAdwqaLIEALGP---HFRCLAIDLPGHGSSqSPSDIERYDFEEAAQ---LLLATLLDQLGIEPFFLVG 77

                          90
                  ....*....|.
gi 488409257  109 YSMGGMIATRL 119
Cdd:TIGR03695  78 YSMGGRIALYY 88
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 53-116 1.93e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 44.83  E-value: 1.93e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488409257  53 PYFREYQMIFVNCPGRGESSELTTtkDTLDDYSEriydVLSQVVEQHGIKKMMLLGYSMGGMIA 116
Cdd:PRK11126  23 EALPDYPRLYIDLPGHGGSAAISV--DGFADVSR----LLSQTLQSYNILPYWLVGYSLGGRIA 80
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 35-290 6.21e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 75.04  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  35 IVFIHGAMMTYRIMAMFEPYFRE-YQMIFVNCPGRGESSeLTTTKDTLDDYSERIYDVLsqvvEQHGIKKMMLLGYSMGG 113
Cdd:COG0596   26 VVLLHGLPGSSYEWRPLIPALAAgYRVIAPDLRGHGRSD-KPAGGYTLDDLADDLAALL----DALGLERVVLVGHSMGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 114 MIATRLLKFNTLPITHLVYLNSAaritpntsmlsrlfsgdskREHLKDEMAAIKNLPQyildktvyaktesakdifsfla 193
Cdd:COG0596  101 MVALELAARHPERVAGLVLVDEV-------------------LAALAEPLRRPGLAPE---------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 194 pvkTILTDIEYSIKADYLPDIEEIEQfPkLLFISGEDDEIIPYTDSHEtllkYQEFGGTAVEVVYPGIGHLdfptvleSQ 273
Cdd:COG0596  140 ---ALAALLRALARTDLRERLARITV-P-TLVIWGEKDPIVPPALARR----LAELLPNAELVVLPGAGHF-------PP 203

                        250
                 ....*....|....*..
gi 488409257 274 EDDTKGIVDQIKAWVAS 290
Cdd:COG0596  204 LEQPEAFAAALRDFLAR 220
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
34-290 2.37e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 65.02  E-value: 2.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  34 IIVFIHGAMMTYRIMAMFEPYFRE--YQMIFVNCPGRGESSELTTTKDTLDDYSERIYDVLSQVVEQHGiKKMMLLGYSM 111
Cdd:COG2267   30 TVVLVHGLGEHSGRYAELAEALAAagYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDLRAALDALRARPG-LPVVLLGHSM 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 112 GGMIATRLLKFNTLPITHLVYLNSAARITPNTSMLSRLFSgdskrehlkdEMAAIKNLPQyildktvyaktesakdifsF 191
Cdd:COG2267  109 GGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPSARWLR----------ALRLAEALAR-------------------I 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 192 LAPVktiltdieysikadylpdieeieqfpklLFISGEDDEIIPYTDSHETllkYQEFGGTAVEVVYPGIGHLDFptvle 271
Cdd:COG2267  160 DVPV----------------------------LVLHGGADRVVPPEAARRL---AARLSPDVELVLLPGARHELL----- 203

                        250
                 ....*....|....*....
gi 488409257 272 sQEDDTKGIVDQIKAWVAS 290
Cdd:COG2267  204 -NEPAREEVLAAILAWLER 221
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 35-142 3.97e-11

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 58.69  E-value: 3.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  35 IVFIHGAMMTYRIMAMFEPYFRE--YQMIFVNCPgrgesseltTTKDTLDDYSERIYDVLSQVVEQHGIKKMMLLGYSMG 112
Cdd:COG1075    8 VVLVHGLGGSAASWAPLAPRLRAagYPVYALNYP---------STNGSIEDSAEQLAAFVDAVLAATGAEKVDLVGHSMG 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 488409257 113 GMIATRLLKFNTLP--ITHLVYLNsaariTPN 142
Cdd:COG1075   79 GLVARYYLKRLGGAakVARVVTLG-----TPH 105
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-264 1.98e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 59.41  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   35 IVFIHGAmmTYRIMAMFEPYFREYQMIFVNCPGRGESSELTTTKDTLDDYSeriyDVLSQVVEQHGIkkmMLLGYSMGGM 114
Cdd:pfam12697   1 VVLVHGA--GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLA----ALLDELGAARPV---VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  115 IATRLLkfnTLPITHLVYLNSAARITPNTSMLSRLFsgdskrEHLKDEMAAIKNLPQYILDKTVYAKTESAKDIFSFLAP 194
Cdd:pfam12697  72 VALAAA---AAALVVGVLVAPLAAPPGLLAALLALL------ARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALAR 142

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  195 VKTILTDIEYSIKADYlpdieeiEQFPKLLFISGEDDEIIPytdshETLLKYQEFGGTAVEVVYPGIGHL 264
Cdd:pfam12697 143 LAALLAALALLPLAAW-------RDLPVPVLVLAEEDRLVP-----ELAQRLLAALAGARLVVLPGAGHL 200
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
35-290 1.34e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 54.56  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  35 IVFIHGAMMTYRIMAMFEPYFRE--YQMIFVNCPGRGESSE---LTTTKDTLDDySERIYDVLSQVVEqhgikKMMLLGY 109
Cdd:COG1647   18 VLLLHGFTGSPAEMRPLAEALAKagYTVYAPRLPGHGTSPEdllKTTWEDWLED-VEEAYEILKAGYD-----KVIVIGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 110 SMGGMIATRLLKfNTLPITHLVYLNSAARITPNTSMLSRLFSgdskreHLKDEMAAI-KNLPQYILDKTVYAKT--ESAK 186
Cdd:COG1647   92 SMGGLLALLLAA-RYPDVAGLVLLSPALKIDDPSAPLLPLLK------YLARSLRGIgSDIEDPEVAEYAYDRTplRALA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 187 DIFSFLAPVKtiltdieysikadylPDIEEIEQfPkLLFISGEDDEIIPYTDSHETllkYQEFGGTAVE-VVYPGIGHLD 265
Cdd:COG1647  165 ELQRLIREVR---------------RDLPKITA-P-TLIIQSRKDEVVPPESARYI---YERLGSPDKElVWLEDSGHVI 224

                        250       260
                 ....*....|....*....|....*
gi 488409257 266 fptvleSQEDDTKGIVDQIKAWVAS 290
Cdd:COG1647  225 ------TLDKDREEVAEEILDFLER 243
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 34-119 1.04e-07

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 51.83  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   34 IIVFIHGAMMTYR----IMAMFEPyfrEYQMIFVNCPGRGES-SELTTTKDTLDDYSEriyDVLSQVVEQHGIKKMMLLG 108
Cdd:TIGR03695   4 VLVFLHGFLGSGAdwqaLIEALGP---HFRCLAIDLPGHGSSqSPSDIERYDFEEAAQ---LLLATLLDQLGIEPFFLVG 77

                          90
                  ....*....|.
gi 488409257  109 YSMGGMIATRL 119
Cdd:TIGR03695  78 YSMGGRIALYY 88
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 33-266 1.99e-07

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 50.97  E-value: 1.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   33 DIIVFIHG-AMMTYRIMAMFEP-YFREYQMIFVNCPGRGESSELTTtkdtLDDYS-ERIYDVLSQVVEQHGIKKMMLLGY 109
Cdd:pfam00561   1 PPVLLLHGlPGSSDLWRKLAPAlARDGFRVIALDLRGFGKSSRPKA----QDDYRtDDLAEDLEYILEALGLEKVNLVGH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  110 SMGGMIATRLLKFNTLPITHLVYLNSAARITPNTSMLSRLFSGDSKRehLKDEMAAIKNLPQYILDKTVYAKTESAKDIF 189
Cdd:pfam00561  77 SMGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGF--FDGFVADFAPNPLGRLVAKLLALLLLRLRLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  190 SFLAP-VKTILTDIEYSIK---ADYLPDIEEIEQFP----------KLLFISGEDDEIIPytdsHETLLKYQEFGGTAVE 255
Cdd:pfam00561 155 KALPLlNKRFPSGDYALAKslvTGALLFIETWSTELrakflgrldePTLIIWGDQDPLVP----PQALEKLAQLFPNARL 230

                         250
                  ....*....|.
gi 488409257  256 VVYPGIGHLDF 266
Cdd:pfam00561 231 VVIPDAGHFAF 241
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
34-263 1.66e-06

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 48.09  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  34 IIVFIHG----AMMTYRIMAmfePYFRE--YQMIFVNCPGRGESsELTTTKDTLDDYSeriyDVLSQVVEQHGI--KKMM 105
Cdd:COG1506   25 VVVYVHGgpgsRDDSFLPLA---QALASrgYAVLAPDYRGYGES-AGDWGGDEVDDVL----AAIDYLAARPYVdpDRIG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 106 LLGYSMGGMIATRLLKFNTLPITHLVylnSAAritPNTSMLSRLFSGDSKREHLKDemaaiknlpQYILDKTVYAKTesa 185
Cdd:COG1506   97 IYGHSYGGYMALLAAARHPDRFKAAV---ALA---GVSDLRSYYGTTREYTERLMG---------GPWEDPEAYAAR--- 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488409257 186 kDIFSFLAPVKTiltdieysikadylpdieeieqfpKLLFISGEDDEIIPYTDSHETLLKYQEFGGTAVEVVYPGIGH 263
Cdd:COG1506  159 -SPLAYADKLKT------------------------PLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGH 211
YpfH COG0400
Predicted esterase [General function prediction only];
81-263 1.08e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 45.28  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  81 LDDYSERIYDVLSQVVEQHGI--KKMMLLGYSMGGMIATRLLKFNTLPITHLVylnsaaritpntsmlsrLFSGdskreh 158
Cdd:COG0400   66 LAAAAEALAAFIDELEARYGIdpERIVLAGFSQGAAMALSLALRRPELLAGVV-----------------ALSG------ 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 159 lkdemaaiknlpqyildktvyaktesakdifsflapvktiltdieYSIKADYLPDIEEIEQFPKLLFISGEDDEIIPYTD 238
Cdd:COG0400  123 ---------------------------------------------YLPGEEALPAPEAALAGTPVFLAHGTQDPVIPVER 157

                        170       180
                 ....*....|....*....|....*
gi 488409257 239 SHETLLKYQEFGGTAVEVVYPGiGH 263
Cdd:COG0400  158 AREAAEALEAAGADVTYREYPG-GH 181
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 53-116 1.93e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 44.83  E-value: 1.93e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488409257  53 PYFREYQMIFVNCPGRGESSELTTtkDTLDDYSEriydVLSQVVEQHGIKKMMLLGYSMGGMIA 116
Cdd:PRK11126  23 EALPDYPRLYIDLPGHGGSAAISV--DGFADVSR----LLSQTLQSYNILPYWLVGYSLGGRIA 80
COG4814 COG4814
Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];
78-121 2.40e-05

Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];


Pssm-ID: 443842  Cd Length: 286  Bit Score: 44.93  E-value: 2.40e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 488409257  78 KDTLDDYSERIYDVLSQVVEQHGIKKMMLLGYSMGGMIATRLLK 121
Cdd:COG4814  110 RDSIKKQAKWLKKVLKYLKKKYGFKKFNAVGHSMGGLALTYYLE 153
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 79-263 2.55e-05

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 44.51  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   79 DTLDDYSERIYDVLSQVVEQHGIKKMMLLGYSMGGMIATRLLKFNTLPITHLVYLNSAARITPNT---------SMLSRL 149
Cdd:pfam12146  53 PSFDDYVDDLDTFVDKIREEHPGLPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLappilkllaKLLGKL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  150 F-----SGDSKREHLKDEMAAIKnlpQYILDKTVYAKTeSAKDIFSFLAPVKTILTDieysikadyLPDIeeieQFPkLL 224
Cdd:pfam12146 133 FprlrvPNNLLPDSLSRDPEVVA---AYAADPLVHGGI-SARTLYELLDAGERLLRR---------AAAI----TVP-LL 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 488409257  225 FISGEDDEIIPYTDSHETllkYQEFGGTAVEV-VYPGIGH 263
Cdd:pfam12146 195 LLHGGADRVVDPAGSREF---YERAGSTDKTLkLYPGLYH 231
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 26-116 9.32e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 44.08  E-value: 9.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257   26 AGDRSSSDIIVFIHGAMMTYR----IMAMFEPYFReyqMIFVNCPGRGESSELTTTKDTLDDYS---ERIYDVLSQVVEQ 98
Cdd:PLN02980 1365 VGQNAEGSVVLFLHGFLGTGEdwipIMKAISGSAR---CISIDLPGHGGSKIQNHAKETQTEPTlsvELVADLLYKLIEH 1441

                          90
                  ....*....|....*...
gi 488409257   99 HGIKKMMLLGYSMGGMIA 116
Cdd:PLN02980 1442 ITPGKVTLVGYSMGARIA 1459
DUF915 pfam06028
Alpha/beta hydrolase of unknown function (DUF915); This family consists of several bacterial ...
 80-121 1.54e-04

Alpha/beta hydrolase of unknown function (DUF915); This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.


Pssm-ID: 283645 [Multi-domain]  Cd Length: 253  Bit Score: 42.35  E-value: 1.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 488409257   80 TLDDYSERIYDVLSQVVEQHGIKKMMLLGYSMGGMIATRLLK 121
Cdd:pfam06028  79 SFDKQAKWLKKVMSYLQKHYNIKKFNAVGHSMGGLAWTYYLE 120
PLN02965 PLN02965
Probable pheophorbidase
 36-235 1.39e-03

Probable pheophorbidase


Pssm-ID: 178549 [Multi-domain]  Cd Length: 255  Bit Score: 39.52  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257  36 VFIHGAMMT----YRIMAMFEPyfREYQMIFVNCPGRGESSELTTTKDTLDDYSERIYDVLSQVVEQHgikKMMLLGYSM 111
Cdd:PLN02965   7 VFVHGASHGawcwYKLATLLDA--AGFKSTCVDLTGAGISLTDSNTVSSSDQYNRPLFALLSDLPPDH---KVILVGHSI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488409257 112 GGMIATRLLKFNTLPITHLVYLnSAARITPNTSMLSRLFSGDSKREHLKDEM--AAIKNLPQYILdktvyAKTESAKDIF 189
Cdd:PLN02965  82 GGGSVTEALCKFTDKISMAIYV-AAAMVKPGSIISPRLKNVMEGTEKIWDYTfgEGPDKPPTGIM-----MKPEFVRHYY 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488409257 190 SFLAPvktiLTDIEYSIK------------ADYLPDIEEIEQFPKLLFISGEDDEIIP 235
Cdd:PLN02965 156 YNQSP----LEDYTLSSKllrpapvrafqdLDKLPPNPEAEKVPRVYIKTAKDNLFDP 209
PhaC COG3243
Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];
80-117 6.19e-03

Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];


Pssm-ID: 442475 [Multi-domain]  Cd Length: 545  Bit Score: 38.01  E-value: 6.19e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 488409257  80 TLDDYSER-IYDVLSQVVEQHGIKKMMLLGYSMGGMIAT 117
Cdd:COG3243  254 GLDDYVEDgILAAVDAVREITGEDKVNLLGYCLGGTLLA 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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