NCBI Conserved Domain Search

Conserved domains on [gi|488378290|ref|WP_002447675|]

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MULTISPECIES: PLP-dependent transferase [Staphylococcus]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

AAT_I super family

cl18945

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...

3-362

0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).

The actual alignment was detected with superfamily member PRK08247:

Pssm-ID: 450240 [Multi-domain] Cd Length: 366 Bit Score: 511.94 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   3 DTDLAQIA-LTQDHTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICN 81
Cdd:PRK08247   6 ETKLAQIGnRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVMS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  82 IFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKH 161
Cdd:PRK08247  86 LFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 162 QLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK08247 166 GLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQTHV 321
Cdd:PRK08247 246 TLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGRGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPATQTHA 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488378290 322 DMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK08247 326 DIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366

Name

Accession

Description

Interval

E-value

PRK08247

methionine biosynthesis PLP-dependent protein;

3-362

0e+00

methionine biosynthesis PLP-dependent protein;

Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 511.94 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   3 DTDLAQIA-LTQDHTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICN 81
Cdd:PRK08247   6 ETKLAQIGnRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVMS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  82 IFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKH 161
Cdd:PRK08247  86 LFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 162 QLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK08247 166 GLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQTHV 321
Cdd:PRK08247 246 TLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGRGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPATQTHA 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488378290 322 DMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK08247 326 DIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366

MetC

COG0626

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...

14-359

2.71e-150

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis

Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 429.08 E-value: 2.71e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  14 DHTGAIANPIYLSTAYQHP--------HLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLIC-NIFK 84
Cdd:COG0626   16 PQTGAVSPPIYLTSTFVFPsaealaarFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGMAAISAVLlALLK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  85 PGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMiEI-DVEPYYILSKKHQL 163
Cdd:COG0626   96 AGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTL-EVvDIAAIAAIAHAAGA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 164 LTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTL 243
Cdd:COG0626  175 LLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 244 HLRIERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYS-VAKFLENLDICIFAESLG 306
Cdd:COG0626  255 ALRMERHCENALAVAEWLEAHPAVARVYYpglpshpghelakrqmSGFGGMLSFELKGGREaARRFLDALKLFTLAVSLG 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488378290 307 GTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:COG0626  335 GVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387

Cys_Met_Meta_PP

pfam01053

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...

16-359

2.21e-149

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.

Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 426.26 E-value: 2.21e-149

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   16 TGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGDEILVAFD 94
Cdd:pfam01053  15 TGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAILALLKAGDHIVATDD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   95 LYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTP 174
Cdd:pfam01053  95 LYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  175 YLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENA 254
Cdd:pfam01053 175 YLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENA 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  255 QKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYT 317
Cdd:pfam01053 255 QKVAEFLESHPKVEKVYYpglpshpghelakrqmKGFGGMLSFELKGGLEAAkKFLDNLKLFSLAVSLGGVESLISHPAT 334

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 488378290  318 QTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:pfam01053 335 MTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376

CGS_like

cd00614

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...

17-359

8.18e-134

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.

Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 386.56 E-value: 8.18e-134

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHPHLGEST--------GYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPGD 87
Cdd:cd00614    1 GAVAPPIYQTSTFVFPSPAEAAdlfalregGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTvLLALLKAGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  88 EILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTII 167
Cdd:cd00614   81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 168 DNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRI 247
Cdd:cd00614  161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 248 ERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAY-SVAKFLENLDICIFAESLGGTET 310
Cdd:cd00614  241 ERHSENALKVAEFLEKHPKVERVYYpglpshpqhelakkqmSGYGGVFSFELKGGLeAAKKFLNALKLFSLAVSLGGVES 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 488378290 311 FITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:cd00614  321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369

O_succ_thio_ly

TIGR02080

O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ...

17-358

9.62e-102

O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]

Pssm-ID: 131135 Cd Length: 382 Bit Score: 305.57 E-value: 9.62e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   17 GAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIF-KPGDEILVAFDL 95
Cdd:TIGR02080  20 GCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTTALlGPDDLLVAPHDC 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   96 YGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY 175
Cdd:TIGR02080 100 YGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSPA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  176 LSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQ 255
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  256 KLAQRCRQSDSIDEVLYSG-------------RTG---MLSLRLNQAY-SVAKFLENLDICIFAESLGGTETFITFPYTQ 318
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGlpdhpgheiaarqQKGfgaMLSFELKGGEqTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 488378290  319 THVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGL 379

Name

Accession

Description

Interval

E-value

PRK08247

methionine biosynthesis PLP-dependent protein;

3-362

0e+00

methionine biosynthesis PLP-dependent protein;

Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 511.94 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   3 DTDLAQIA-LTQDHTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICN 81
Cdd:PRK08247   6 ETKLAQIGnRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVMS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  82 IFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKH 161
Cdd:PRK08247  86 LFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 162 QLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK08247 166 GLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQTHV 321
Cdd:PRK08247 246 TLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGRGGMLSFRLQDEEWVNPFLKSLKLITFAESLGGVESFITYPATQTHA 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488378290 322 DMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK08247 326 DIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366

MetC

COG0626

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...

14-359

2.71e-150

Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 429.08 E-value: 2.71e-150

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  14 DHTGAIANPIYLSTAYQHP--------HLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLIC-NIFK 84
Cdd:COG0626   16 PQTGAVSPPIYLTSTFVFPsaealaarFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGMAAISAVLlALLK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  85 PGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMiEI-DVEPYYILSKKHQL 163
Cdd:COG0626   96 AGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTL-EVvDIAAIAAIAHAAGA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 164 LTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTL 243
Cdd:COG0626  175 LLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 244 HLRIERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYS-VAKFLENLDICIFAESLG 306
Cdd:COG0626  255 ALRMERHCENALAVAEWLEAHPAVARVYYpglpshpghelakrqmSGFGGMLSFELKGGREaARRFLDALKLFTLAVSLG 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488378290 307 GTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:COG0626  335 GVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387

Cys_Met_Meta_PP

pfam01053

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...

16-359

2.21e-149

Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 426.26 E-value: 2.21e-149

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   16 TGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGDEILVAFD 94
Cdd:pfam01053  15 TGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAILALLKAGDHIVATDD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   95 LYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTP 174
Cdd:pfam01053  95 LYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  175 YLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENA 254
Cdd:pfam01053 175 YLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENA 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  255 QKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYT 317
Cdd:pfam01053 255 QKVAEFLESHPKVEKVYYpglpshpghelakrqmKGFGGMLSFELKGGLEAAkKFLDNLKLFSLAVSLGGVESLISHPAT 334

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 488378290  318 QTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:pfam01053 335 MTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376

CGS_like

cd00614

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...

17-359

8.18e-134

Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 386.56 E-value: 8.18e-134

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHPHLGEST--------GYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPGD 87
Cdd:cd00614    1 GAVAPPIYQTSTFVFPSPAEAAdlfalregGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTvLLALLKAGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  88 EILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTII 167
Cdd:cd00614   81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 168 DNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRI 247
Cdd:cd00614  161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 248 ERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAY-SVAKFLENLDICIFAESLGGTET 310
Cdd:cd00614  241 ERHSENALKVAEFLEKHPKVERVYYpglpshpqhelakkqmSGYGGVFSFELKGGLeAAKKFLNALKLFSLAVSLGGVES 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 488378290 311 FITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:cd00614  321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369

PRK07269

cystathionine gamma-synthase; Reviewed

3-360

6.05e-131

cystathionine gamma-synthase; Reviewed

Pssm-ID: 235983 Cd Length: 364 Bit Score: 379.16 E-value: 6.05e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   3 DTDLAQIALTQDH-TGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICN 81
Cdd:PRK07269   8 NTILAQAGIKSDEaTGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  82 IFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDflNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKH 161
Cdd:PRK07269  88 VFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYAN--TEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 162 QLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK07269 166 GAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQTHV 321
Cdd:PRK07269 246 TLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGKGGMISFKVADETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHA 325

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 488378290 322 DMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALEN 360
Cdd:PRK07269 326 DIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364

PRK07671

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;

15-359

1.44e-115

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;

Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 340.55 E-value: 1.44e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  15 HTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIFKPGDEILVAFD 94
Cdd:PRK07671  17 STGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMMLFSSGDHVILTDD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  95 LYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTP 174
Cdd:PRK07671  97 VYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTP 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 175 YLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENA 254
Cdd:PRK07671 177 YWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 255 QKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQ 318
Cdd:PRK07671 257 RAIAEFLNNHPAVNKVYYpglpshpnhelakeqaNGFGGMISFDVGSEETANKVLERLQYFTLAESLGAVESLISIPSQM 336

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488378290 319 THVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK07671 337 THASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377

PRK06176

cystathionine gamma-synthase;

16-359

5.37e-112

cystathionine gamma-synthase;

Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 331.48 E-value: 5.37e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIFKPGDEILVAFDL 95
Cdd:PRK06176  18 TGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLFQSGDHVLLGDDV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  96 YGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY 175
Cdd:PRK06176  98 YGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPY 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 176 LSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQ 255
Cdd:PRK06176 178 YQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNAL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 256 KLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFPYTQT 319
Cdd:PRK06176 258 CVAEFLEKHPKVEKVYYpglpthpnhelakkqmRGFSGMLSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMT 337

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 488378290 320 HVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK06176 338 HACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 377

PRK08064

cystathionine beta-lyase MetC;

3-359

3.52e-110

cystathionine beta-lyase MetC;

Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 327.11 E-value: 3.52e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   3 DTDLAQIALTQD-HTGAIANPIYLSTAYqHPHLGESTG-YDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLIC 80
Cdd:PRK08064   8 DTLLLHNQYKHDkQTGAVNVPIYHASTF-HQFDFDTFGkYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  81 NIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKK 160
Cdd:PRK08064  87 LLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 161 HQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGL 240
Cdd:PRK08064 167 IGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 241 KTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTG----------------MLSLRLNQAYSVAKFLENLDICIFAES 304
Cdd:PRK08064 247 KTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQThlgfdiqqsqatsagaVLSFTLQSEEAVRQFVSHVKLPVFAVS 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488378290 305 LGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK08064 327 LGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381

PRK07811

cystathionine gamma-synthase; Provisional

16-360

1.05e-106

cystathionine gamma-synthase; Provisional

Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 318.13 E-value: 1.05e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAYQHPHLGE-STGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LICNIFKPGDEILVAF 93
Cdd:PRK07811  28 TGAVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATDcLLRAVLRPGDHIVIPN 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  94 DLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLT 173
Cdd:PRK07811 108 DAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNTFAS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 174 PYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQEN 253
Cdd:PRK07811 188 PYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSEN 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 254 AQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPY 316
Cdd:PRK07811 268 AEAVAEFLAGHPEVSTVLYpglpshpghevaarqmRGFGGMVSVRLAGGEEAArDFCARTKVFTLAESLGGVESLIEHPS 347

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488378290 317 TQTH-------VDMPDEekdkrgideyLIRLSVGIEDYNDIEADIIQALEN 360
Cdd:PRK07811 348 AMTHastagsqLEVPDD----------LVRLSVGIEDVADLLADLEQALGQ 388

O_succ_thio_ly

TIGR02080

O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ...

17-358

9.62e-102

Pssm-ID: 131135 Cd Length: 382 Bit Score: 305.57 E-value: 9.62e-102

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   17 GAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIF-KPGDEILVAFDL 95
Cdd:TIGR02080  20 GCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTTALlGPDDLLVAPHDC 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   96 YGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY 175
Cdd:TIGR02080 100 YGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSPA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  176 LSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQ 255
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  256 KLAQRCRQSDSIDEVLYSG-------------RTG---MLSLRLNQAY-SVAKFLENLDICIFAESLGGTETFITFPYTQ 318
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGlpdhpgheiaarqQKGfgaMLSFELKGGEqTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 488378290  319 THVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGL 379

MET17

COG2873

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...

14-362

8.18e-100

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis

Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 301.95 E-value: 8.18e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  14 DHTGAIANPIYLSTAYQHP---HLG-----ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFK 84
Cdd:COG2873   21 PTTGARAVPIYQTTSYVFDdaeHAAdlfalKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALATASGQAAITLaILNLAE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  85 PGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLL 164
Cdd:COG2873  101 AGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHGVP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 165 TIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTvkDA------------QLAEQLNQFHNM--------- 223
Cdd:COG2873  181 LIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIV--DGgnfdwaangkfpELTEPDPSYHGLvyteafgna 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 -------------IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRT-------------- 276
Cdd:COG2873  259 afitkarvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPshpyhelaqkylpk 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 277 ---GMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEA 352
Cdd:COG2873  339 gagGVLTFGLKGGREAGkKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVGIEDIDDIIA 418

                        410
                 ....*....|
gi 488378290 353 DIIQALENSK 362
Cdd:COG2873  419 DLDQALAAAT 428

PRK06767

methionine gamma-lyase; Provisional

15-361

8.44e-96

methionine gamma-lyase; Provisional

Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 290.59 E-value: 8.44e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  15 HTGAIANPIYLSTAYQHPHL--------GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLIC-NIFKP 85
Cdd:PRK06767  20 HKGSLTPPLFQTSTFTFETAqqgeasfaGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATLiGFLKA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  86 GDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLT 165
Cdd:PRK06767 100 GDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 166 IIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHL 245
Cdd:PRK06767 180 IVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAV 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 246 RIERSQENAQKLAQRCRQSDSIDEVLYSGRT----------GMLSLRLNQAYS-VAKFLENLDICIFAESLGGTETFITF 314
Cdd:PRK06767 260 RMDRHCDNAEKIVSFLKNHDAVEGVWYPEGElasrqmkrggGVISFSIKGGKEeTQAFINDLHFITIAVSLGDTETLIQH 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 488378290 315 PYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENS 361
Cdd:PRK06767 340 PATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386

cysta_beta_ly_E

TIGR01329

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...

3-358

5.95e-92

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.

Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 280.18 E-value: 5.95e-92

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290    3 DTDLAQIALTQDHTGAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNI 82
Cdd:TIGR01329   2 STLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   83 FKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQ 162
Cdd:TIGR01329  82 LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  163 LLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKT 242
Cdd:TIGR01329 162 ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  243 LHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAY-------------SVA---KFLENLDICIFAESLG 306
Cdd:TIGR01329 242 LAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQakgagsvlsfetgSVAlskRLVEATKLFSITVSFG 321

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488378290  307 GTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:TIGR01329 322 SVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373

PRK08574

cystathionine gamma-synthase family protein;

14-360

8.82e-92

cystathionine gamma-synthase family protein;

Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 280.03 E-value: 8.82e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  14 DHTGAIANPIYLSTAYQHPhlGEST----GYD--YTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LICNIFKPG 86
Cdd:PRK08574  15 DPYGSLQPPIYLTALFRQE--GEAYpsdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIStLFFSLLKAG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  87 DEILVAFDLYGGTFRLFDFYEKqYGLKFKyvdfLNYEEVEKNI----TPQTRALFIEPISNPQMIEIDVePYYI-LSKKH 161
Cdd:PRK08574  93 DRVVLPMEAYGTTLRLLKSLEK-FGVKVV----LAYPSTEDIIeaikEGRTKLVFIETMTNPTLKVIDV-PEVAkAAKEL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 162 QLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK08574 167 GAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLK 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRT------------------GMLSLRLNQAYS-VAKFLENLDICIFA 302
Cdd:PRK08574 247 TLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPsdpyhgvakrlfgkdlygGVVSFRVKGGRDaVLKFLRSLKLIKPS 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488378290 303 ESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALEN 360
Cdd:PRK08574 327 PSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384

met_gam_lyase

TIGR01328

methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ...

14-359

4.65e-89

methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]

Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 273.30 E-value: 4.65e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   14 DHTGAIANPIYLSTAYQHPHL--------GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LICNIFK 84
Cdd:TIGR01328  17 DQFGALTPPIYQTSTFVFDSCeqggnrfaGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAaTLLTILK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   85 PGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLL 164
Cdd:TIGR01328  97 AGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVK 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  165 TIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAE-QLNQFHNMIGATLSPLDSYLLQRGLKTL 243
Cdd:TIGR01328 177 VIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPFDAWLILRGLKTL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  244 HLRIERSQENAQKLAQRCRQSDSIDEVLYSGRT----------------GMLSLRLNQAYS-VAKFLENLDICIFAESLG 306
Cdd:TIGR01328 257 NIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEdhpghdiaakqmrmggGMITFELKGGFAgAKKLLNNLKLIRLAVSLG 336

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488378290  307 GTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:TIGR01328 337 DAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALD 389

PRK08045

cystathionine gamma-synthase; Provisional

17-359

9.17e-88

cystathionine gamma-synthase; Provisional

Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 269.84 E-value: 9.17e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIF-KPGDEILVAFDL 95
Cdd:PRK08045  21 GCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFlKPGDLLVAPHDC 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  96 YGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY 175
Cdd:PRK08045 101 YGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 176 LSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQ 255
Cdd:PRK08045 181 LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQ 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 256 KLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLN-QAYSVAKFLENLDICIFAESLGGTETFITFPYTQ 318
Cdd:PRK08045 261 AIVKYLQTQPLVKKLYHpslpenqgheiaarqqKGFGAMLSFELDgDEQTLRRFLGGLSLFTLAESLGGVESLISHAATM 340

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488378290 319 THVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK08045 341 THAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381

PRK08776

O-succinylhomoserine (thiol)-lyase;

17-362

2.04e-87

O-succinylhomoserine (thiol)-lyase;

Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 269.55 E-value: 2.04e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICN-IFKPGDEILVAFDL 95
Cdd:PRK08776  29 GAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNaLLQPGDTLVVPHDA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  96 YGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEpyYILSKKHQL--LTIIDNTFLT 173
Cdd:PRK08776 109 YGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLR--FVIEAAHKVgaLTVVDNTFLS 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 174 PYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQEN 253
Cdd:PRK08776 187 PALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQEN 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 254 AQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAY-SVAKFLENLDICIFAESLGGTETFITFPY 316
Cdd:PRK08776 267 ADAIAALLDGHAAVNQVYYpglashpghalaarqqKGFGAMLSFELEGGEaAVRAFVDGLRYFTLAESLGGVESLIAHPA 346

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 488378290 317 TQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK08776 347 SMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARAE 392

PRK08249

cystathionine gamma-synthase family protein;

15-359

7.95e-87

cystathionine gamma-synthase family protein;

Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 267.76 E-value: 7.95e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  15 HTGAIANPIYLSTAYQHPH--------LGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIF-KP 85
Cdd:PRK08249  23 PYGATQVPVVLSVAYGYDDidewydvaLGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYTFlKP 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  86 GDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLT 165
Cdd:PRK08249 103 GDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALV 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 166 IIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVtVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHL 245
Cdd:PRK08249 183 VVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVV-CGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 246 RIERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAY-SVAKFLENLDICIFAESLGGT 308
Cdd:PRK08249 262 RVRQQQESAMALAKYLQTHPKVEAVYYpglethpnheiakaqmRGFGGILSFVLKGGMdTVKRLLPKLRYAHRAANLGAV 341

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488378290 309 ETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK08249 342 ETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFA 392

PRK08861

O-succinylhomoserine (thiol)-lyase;

1-362

1.03e-86

O-succinylhomoserine (thiol)-lyase;

Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 267.15 E-value: 1.03e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   1 MKDTDLAQIAL-------TQDHtgAIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGM 73
Cdd:PRK08861   1 MSTRKPATIAVrtgiesdSQYH--AVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  74 AAIQLICNIFKPGDEILVA-FDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVE 152
Cdd:PRK08861  79 SALNLWVSALLGPDDLIVApHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 153 PYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLD 232
Cdd:PRK08861 159 ELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 233 SYLLQRGLKTLHLRIERSQENAQKLAqRCRQSDSIDEVLY-----------------SGRTGMLSLRLNQAYSVAK-FLE 294
Cdd:PRK08861 239 SYMTLRGIRTLGARMRVHEESAQQIL-AYLQTQSLVGTIYhpslpehpgheiakkqqSGFGSMLSFEFAGSFEQLKvFVK 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488378290 295 NLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK08861 318 ALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAA 385

PLN02509

cystathionine beta-lyase

18-358

1.32e-86

cystathionine beta-lyase

Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 269.59 E-value: 1.32e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  18 AIANPIYLSTAYQHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLICNIFKPGDEILVAFDLYG 97
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  98 GTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPYLS 177
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLS 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 178 TPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKL 257
Cdd:PLN02509 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 258 AQRCRQSDSIDEVLYSGRTGM--LSLRLNQAY---SVAKFL-----------ENLDICIFAESLGGTETFITFPYTQTHV 321
Cdd:PLN02509 343 AMYLSSHPRVKKVYYAGLPDHpgHHLHFSQAKgagSVFSFItgsvalskhlvETTKYFSIAVSFGSVKSLISMPCFMSHA 422

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 488378290 322 DMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:PLN02509 423 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459

PRK07503

methionine gamma-lyase; Provisional

13-363

2.78e-86

methionine gamma-lyase; Provisional

Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 266.67 E-value: 2.78e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  13 QDHTGAIANPIYLSTAYQHPHL--------GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIF 83
Cdd:PRK07503  22 LDHGGALVPPVYLTATFAFPTAeygaecfaGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAItATLWTLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  84 KPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQL 163
Cdd:PRK07503 102 RPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 164 LTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVtVKDAQLAEQ--LNQFHNMIGATLSPLDSYLLQRGLK 241
Cdd:PRK07503 182 KVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGGKALADRirLEGLKDMTGAVMSPFDAFLLMRGLK 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 242 TLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRT----------------GMLSLRLNQAYSVAK-FLENLDICIFAES 304
Cdd:PRK07503 261 TLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPsfaqhalaqrqmalpgGMIAFELKGGIAAGRrFMNALQLFARAVS 340

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488378290 305 LGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSKV 363
Cdd:PRK07503 341 LGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACAV 399

PRK06234

methionine gamma-lyase; Provisional

17-359

4.02e-86

methionine gamma-lyase; Provisional

Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 265.92 E-value: 4.02e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIY------LSTAYQ--HPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGD 87
Cdd:PRK06234  25 GSLATPIYqtstfiFDSAEQggRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAIsSSLWSALKAGD 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  88 EILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKH--QLLT 165
Cdd:PRK06234 105 HVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHENnkECLV 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 166 IIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVtVKDAQLAEQLNQF--HNMIGATLSPLDSYLLQRGLKTL 243
Cdd:PRK06234 185 FVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLFgiKDMTGSVIGPFEAFLIIRGMKTL 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 244 HLRIERSQENAQKLAQRCRQSDSIDEVLYSGRT----------------GMLSLRLNQAYSVAK-FLENLDICIFAESLG 306
Cdd:PRK06234 264 QIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLEsfeyyelakkqmslpgAMISFELKGGVEEGKvVMNNVKLATLAVSLG 343

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488378290 307 GTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK06234 344 DAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALD 396

OAH_OAS_sulfhy

TIGR01326

OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ...

16-359

4.70e-85

OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]

Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 263.84 E-value: 4.70e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   16 TGAIANPIYLSTAYQH---PHLG-----ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPG 86
Cdd:TIGR01326  17 TGSRAVPIYQTTSYVFdstEHAAalfglQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQAAITYaILNLAGAG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   87 DEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTI 166
Cdd:TIGR01326  97 DNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEAIAEVAHRHGIPLI 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  167 IDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVT---------VKDAQLAEQLNQFHNMI------------- 224
Cdd:TIGR01326 177 VDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnnGRFPLFTTPDPSYHGLVftetlgnpafilk 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  225 ---------GATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAY-------- 287
Cdd:TIGR01326 257 arvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHHALAKKYlpkgfgav 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  288 ----------SVAKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQA 357
Cdd:TIGR01326 337 lsfeikggreAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSVGIENIDDIIADLEQA 416


                  ..
gi 488378290  358 LE 359
Cdd:TIGR01326 417 LE 418

PRK06434

cystathionine gamma-lyase; Validated

17-358

6.13e-80

cystathionine gamma-lyase; Validated

Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 249.82 E-value: 6.13e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHP------HLGESTG--YDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGD 87
Cdd:PRK06434  25 GNVTTPIFETSTFVYPnsekeaYMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAItSAILSLIKKGK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  88 EILVAFDLYGGTFRLFDFYEKQYGLKFKYVDF--LNYEEVEKNitpQTRALFIEPISNPQMIEIDVEPyyILSKKHQLLT 165
Cdd:PRK06434 105 RILSISDLYGQTFYFFNKVLKTLGIHVDYIDTdrLNSLDFDPS---NYDLIYAESITNPTLKVPDIKN--VSSFCHENDV 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 166 IIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHL 245
Cdd:PRK06434 180 IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKTLGL 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 246 RIERSQENAQKLAQRCRQSDSIDEVLY----------SGRTGMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFITFP 315
Cdd:PRK06434 260 RMEKHNKNGMELARFLRDSKKISNVYYpdteigkkvlRGFGGMLSFELRSMEDVHKFIRNLEIPMVAASLGGVESLITLP 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 488378290 316 YTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:PRK06434 340 VETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382

PRK06460

hypothetical protein; Provisional

1-360

9.85e-77

hypothetical protein; Provisional

Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 241.27 E-value: 9.85e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   1 MKDTDLAQIALTQDHTGAIANPIYLSTAYQHPhLGEStgYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LI 79
Cdd:PRK06460   1 MKDATRTVREDIDEATGAITTPIYQTTAYHYP-EGEK--YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAIStTA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  80 CNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSK 159
Cdd:PRK06460  78 LALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 160 KHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKdAQLAEQLNQFHNMIGATLSPLDSYLLQRG 239
Cdd:PRK06460 158 ENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGY-GKLLNVIDQMRRTLGTSLDPHAAYLTLRG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 240 LKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVA-KFLENLDICIFA 302
Cdd:PRK06460 237 IKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYpglkshvdyeiarrvlKGFGGVLSFEVNGGQESAlKVMKSLKLIIPA 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488378290 303 ESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALEN 360
Cdd:PRK06460 317 QTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALST 374

PRK08133

O-succinylhomoserine sulfhydrylase; Validated

35-358

1.25e-76

O-succinylhomoserine sulfhydrylase; Validated

Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 241.44 E-value: 1.25e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  35 GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLIC-NIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLK 113
Cdd:PRK08133  48 GEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASGMAAILAVVmALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 114 FKYVDFLNYEEVEKNITPQTRALFIEPISNPqMIEI-DVEPYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSAT 192
Cdd:PRK08133 128 TTFVDLTDLDAWRAAVRPNTKLFFLETPSNP-LTELaDIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSAT 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 193 KYIGGHNDVLAGVVtVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY 272
Cdd:PRK08133 207 KYLDGQGRVLGGAV-VGSKELMEEVFGFLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFY 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 273 ----------------SGRTGMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDE 335
Cdd:PRK08133 286 pglpshpqhelakrqqKGGGAIVSFEVKGGREAAwRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITE 365

                        330       340
                 ....*....|....*....|...
gi 488378290 336 YLIRLSVGIEDYNDIEADIIQAL 358
Cdd:PRK08133 366 GLIRVAVGLEDVADIKADLARGL 388

PRK08248

homocysteine synthase;

16-362

2.71e-75

homocysteine synthase;

Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 239.36 E-value: 2.71e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAY---QHPHLG-----ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPG 86
Cdd:PRK08248  24 TGSRAVPIYQTTSYgfrDSEHAAnlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQAAITYsILNIASAG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  87 DEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTI 166
Cdd:PRK08248 104 DEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEAVAAIAHEHGIPLI 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 167 IDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVV----------TVKDAQLAEQLNQFHNM------------- 223
Cdd:PRK08248 184 VDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIvdsgkfdwkgSGKFPGLTEPDPSYHGLvytdavgeaayit 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 ---------IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAY------- 287
Cdd:PRK08248 264 karvqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPSYELAKKYlpkgqga 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 288 -----------SVAKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQ 356
Cdd:PRK08248 344 iltfgikggveAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRLSVGTEAIDDILDDLRQ 423


                 ....*.
gi 488378290 357 ALENSK 362
Cdd:PRK08248 424 AIRQSQ 429

PRK05994

O-acetylhomoserine aminocarboxypropyltransferase; Validated

16-359

1.08e-73

O-acetylhomoserine aminocarboxypropyltransferase; Validated

Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 234.99 E-value: 1.08e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAY---QHPHLG-----ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAiQLIC--NIFKP 85
Cdd:PRK05994  23 TGARATPIYQTTSFvfnDADHAAslfglQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASGHAA-QFLVfhTLLQP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  86 GDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLT 165
Cdd:PRK05994 102 GDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAHRAGLPL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 166 IIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVT-------VKDAQ---LAEQLNQFHNM------------ 223
Cdd:PRK05994 182 IVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSGKypmLSEPRPEYHGLvlhetfgnfafa 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 ----------IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAYSV---- 289
Cdd:PRK05994 262 iaarvlglrdLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDDPYHALAQKYSPkgag 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 290 --------------AKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADII 355
Cdd:PRK05994 342 avftfglkggyeagVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRLSIGIEDVDDIIADLE 421


                 ....
gi 488378290 356 QALE 359
Cdd:PRK05994 422 QALA 425

PRK07812

O-acetylhomoserine aminocarboxypropyltransferase; Validated

16-354

1.66e-68

O-acetylhomoserine aminocarboxypropyltransferase; Validated

Pssm-ID: 236105 Cd Length: 436 Bit Score: 221.55 E-value: 1.66e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAY-----QHPH----LGEsTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKP 85
Cdd:PRK07812  29 TNARALPIYQTTSYtfddtDHAAalfgLAE-PGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETFaILNLAGA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  86 GDEILVAFDLYGGTFRLFDFYEKQYGLKFKYV-DFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLL 164
Cdd:PRK07812 108 GDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEAGVP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 165 TIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVV----------------TVKD--------------AQLA 214
Cdd:PRK07812 188 LIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfTTPDpsyhgvvfaelgppAYAL 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 215 EQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTG----------------- 277
Cdd:PRK07812 268 KARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSspwyerakrlapkgtga 347

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488378290 278 MLSLRLNQAYSVAK-FLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADI 354
Cdd:PRK07812 348 VLSFELAGGVEAGKaFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILADL 425

PRK06084

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;

16-362

2.36e-65

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;

Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 213.22 E-value: 2.36e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAY-----QHphlG------ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIF 83
Cdd:PRK06084  18 TKAVAVPIYQTTSYafddtQH---GadlfdlKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYaIQTIA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  84 KPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQL 163
Cdd:PRK06084  95 EAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHGV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 164 LTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVT-------VKDAQLAEQLN----QFHNMI-------- 224
Cdd:PRK06084 175 PLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwAEHKERFALLNtpdpSYHGVTyteafgpa 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 225 --------------GATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAY--- 287
Cdd:PRK06084 255 afigrcrvvplrnmGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYmgg 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 288 ---------------SVAKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEA 352
Cdd:PRK06084 335 kpasilsfgikggqaAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLSIGIEHIDDIIA 414

                        410
                 ....*....|
gi 488378290 353 DIIQALENSK 362
Cdd:PRK06084 415 DLAQALDASK 424

PRK08134

O-acetylhomoserine aminocarboxypropyltransferase; Validated

16-358

6.38e-65

O-acetylhomoserine aminocarboxypropyltransferase; Validated

Pssm-ID: 236159 Cd Length: 433 Bit Score: 212.29 E-value: 6.38e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAYQHP---HLG-----ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPG 86
Cdd:PRK08134  24 TGARAVPIHLTTSFVFRdsdHAAalfnlERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHLaIATLMGAG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  87 DEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTI 166
Cdd:PRK08134 104 SHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGVPLL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 167 IDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVV----------TVKDAQLAEQLNQFHNMI------------ 224
Cdd:PRK08134 184 VDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweaSGKFPELTEPYAGFHGMVfaeestvaafll 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 225 ----------GATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY----SGRTGMLSLRL--NQAYS 288
Cdd:PRK08134 264 rarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHpeleSHPDHALAKRLlpRGAGS 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 289 V------------AKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQ 356
Cdd:PRK08134 344 VfsfdlkggraagRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADDLIDDLKR 423


                 ..
gi 488378290 357 AL 358
Cdd:PRK08134 424 AL 425

PRK05968

hypothetical protein; Provisional

5-362

1.90e-63

hypothetical protein; Provisional

Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 207.24 E-value: 1.90e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   5 DLAQIALTQDHT---GAIANPIYLSTAYQHP--------HLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGM 73
Cdd:PRK05968   9 DLAALITAHDEGnafDAVVPPIFQTSLFTFDsydemedvYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGM 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  74 AAIQ-LICNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNItPQTRALFIEPISNPQMIEIDVE 152
Cdd:PRK05968  89 AAISsTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 153 PYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLD 232
Cdd:PRK05968 168 ALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLSPFE 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 233 SYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY-----------SGRTGMLSLRLNQAYSVAKFLENLDICIF 301
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHpalanhppaglSGTSGLFSFIFREGIDVRAFADALKLFRL 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488378290 302 AESLGGTETFITfPytqthVDMPDEEKDKR------GIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK05968 328 GVSWGGHESLVV-P-----AEVVLQQKAQPnsaarfGVSPRSVRLHVGLEGTEALWADLEQALAAAS 388

PRK07504

O-succinylhomoserine sulfhydrylase; Reviewed

35-359

2.11e-60

O-succinylhomoserine sulfhydrylase; Reviewed

Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 199.60 E-value: 2.11e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  35 GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ--LICNIfKPGDEILVAFDLYGGTFRLFDFYEKQYGL 112
Cdd:PRK07504  52 GEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTaaILCQV-KAGDHVVAARALFGSCRYVVETLLPRYGI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 113 KFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSAT 192
Cdd:PRK07504 131 ESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSAT 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 193 KYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY 272
Cdd:PRK07504 211 KHIDGQGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIY 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 273 SGR----------------TGMLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDE 335
Cdd:PRK07504 291 PGRadhpqadiiakqmtggSTLVAFELKGGKEAAfRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISE 370

                        330       340
                 ....*....|....*....|....
gi 488378290 336 YLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK07504 371 GFLRLSAGLEDTDDLIEDLAAALK 394

PRK05939

cystathionine gamma-synthase family protein;

17-359

8.76e-59

cystathionine gamma-synthase family protein;

Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 195.29 E-value: 8.76e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAYQHPHL--------GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIqliCNIF----K 84
Cdd:PRK05939   8 GAVHKPIHTSVTYGYEDArdlidvfqGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAI---AAVFltllR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  85 PGDEILVAFDLYGGTFRLFDFYeKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLL 164
Cdd:PRK05939  85 AGDHLVSSQFLFGNTNSLFGTL-RGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 165 TIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVT----------------VKDAQLAEQ-LNQ-----FHN 222
Cdd:PRK05939 164 YVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpaYRKGDPQQWgLTQirkkgLRD 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 223 MiGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSG----------------RTGMLSLRLNQA 286
Cdd:PRK05939 244 M-GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGlashpqharatelfrhYGGLLSFELADG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488378290 287 YSVAKFLENLDICIFAESLGGTETFItFPYTQT-HVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK05939 323 IDCFDFLNRLKLVIKATHLGDTRTLV-IPVAPTiYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395

PRK07049

cystathionine gamma-synthase family protein;

17-359

1.22e-57

cystathionine gamma-synthase family protein;

Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 192.96 E-value: 1.22e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  17 GAIANPIYLSTAY------------------QHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL 78
Cdd:PRK07049  34 GAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSGMSAIAT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  79 ICNIF-KPGDEILVAFDLYGGTFRLFDFYEKQYGLKfkYVDF---LNYEEVEKNITP-----QTRALFIEPISNPQMIEI 149
Cdd:PRK07049 114 TLLAFvRPGDVILHSQPLYGGTETLLAKTFRNFGVG--AVGFadgLSEAAIGAAAEAaaakgRVSLILIETPANPTNSLV 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 150 DVEPYYILSKK------HQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAqLAEQLNQFHNM 223
Cdd:PRK07049 192 DVAAVRRVADAiearqgHRPIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGRKA-LIRQVRALRSA 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLY--------------------SGRTGMLSLRL 283
Cdd:PRK07049 271 IGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYlpfldpdsaygavykrqctgAGSTFSFDIKG 350

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488378290 284 NQAYSVaKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK07049 351 GQAAAF-RFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALD 425

PRK07582

cystathionine gamma-lyase; Validated

19-358

4.79e-57

cystathionine gamma-lyase; Validated

Pssm-ID: 236061 Cd Length: 366 Bit Score: 189.82 E-value: 4.79e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  19 IANPIYLSTAYQHPHlGESTGYD-YTRTKNPTRTAFEEAFAQLEKGIA-SFAtsSGMAAIQ-LICNIFKPGDEILVAFDL 95
Cdd:PRK07582  22 VLPGPVFAAPYHLSP-GEPTGPDtYGRASNPTWRALEAALGELEGAEAlVFP--SGMAAITaVLRALLRPGDTVVVPADG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  96 YGGTFRLFDFYEKQYGLKfkyVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY 175
Cdd:PRK07582  99 YYQVRALAREYLAPLGVT---VREAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 176 LSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQ 255
Cdd:PRK07582 176 GQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANAL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 256 KLAQRCRQSDSIDEVLYSGRT----------------GMLSLRLNQAYSVAKFLENLDICIFAESLGGTETFItfpytqt 319
Cdd:PRK07582 256 AVAELLAGHPAVRGVRYPGLPgdpahevaarqmrrfgGLVSFELADAAAAERFVAASRLVVAATSFGGVHTSA------- 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 488378290 320 hvdmpdeekDKRG-----IDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:PRK07582 329 ---------DRRArwgdaVPEGFVRLSCGIEDTDDLVADLERAL 363

PRK06702

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;

22-362

1.04e-54

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;

Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 185.64 E-value: 1.04e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  22 PIYLSTAYQHPHLG--------ESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPGDEILVA 92
Cdd:PRK06702  27 PLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLaVLNICSSGDHLLCS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  93 FDLYGGTFRLFDFYEKQYGLKFKYVD-FLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTF 171
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNpNLTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 172 LTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVV---------TVKDAQLAEQLNQFHNM------------------- 223
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVidggnfdwtNGKYPELVEPDPSYHGVsyvqnfgaaayivkarvql 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 ---IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSGRTGMLSLRLNQAY------------- 287
Cdd:PRK06702 267 lrdYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYlkkgasgvltfgi 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 288 -----SVAKFLENLDICIFAESLGGTETFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQALENSK 362
Cdd:PRK06702 347 kggleAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAALVGGK 426

PRK07810

O-succinylhomoserine sulfhydrylase; Provisional

20-358

1.70e-54

O-succinylhomoserine sulfhydrylase; Provisional

Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 184.17 E-value: 1.70e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  20 ANPIYLSTAY--------QHPHLGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGDEIL 90
Cdd:PRK07810  34 AEALYLTSGYvyesaaaaEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGAGDRLV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  91 VAFDLYGGTFRLFDFYEKQYGLKFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNT 170
Cdd:PRK07810 114 AARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNV 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 171 FLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERS 250
Cdd:PRK07810 194 FATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 251 QENAQKLAQRCRQSDSIDEVLY----------------SGRTGMLSLRLNQAYSVAK-----FLENLDICIFAESLGGTE 309
Cdd:PRK07810 274 NASALRIAEFLEGHPAVRWVRYpflpshpqydlakrqmSGGGTVVTFELDAPEDAAKkrafeVLDKLRVIDISNNLGDAK 353

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 488378290 310 TFITFPYTQTHVDMPDEEKDKRGIDEYLIRLSVGIEDYNDIEADIIQAL 358
Cdd:PRK07810 354 SLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402

PRK05613

O-acetylhomoserine/O-acetylserine sulfhydrylase;

16-359

6.89e-48

O-acetylhomoserine/O-acetylserine sulfhydrylase;

Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 167.74 E-value: 6.89e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  16 TGAIANPIYLSTAY---------QHPHLgESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LICNIFKP 85
Cdd:PRK05613  29 TSARNLPIYQTTSYvfdsaehakQRFAL-EDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETaAILNLAGA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  86 GDEILVAFDLYGGTFRLFDFYEKQYGLKFKYV-DFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLL 164
Cdd:PRK05613 108 GDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 165 TIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGHNDVLAGVV--------TV-KDAQ-----LAEQLNQFHNM------- 223
Cdd:PRK05613 188 LIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwTVeRDGKpvfpyFVTPDPAYHGLkyadlga 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 224 --------------IGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYSG--------------- 274
Cdd:PRK05613 268 pafglkaragllrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGlkdspwyatkeklgl 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 275 -RTG-MLSLRLNQAYSVA-KFLENLDICIFAESLGGTETFITFPYTQTHvDMPDEEKDKR-GIDEYLIRLSVGIEDYNDI 350
Cdd:PRK05613 348 kYTGsVLSFDIKGGKDEAwAFIDALKLHSNLANIGDVRSLVVHPATTTH-SQSDEAGLARaGITQATVRLSVGIEDIDDI 426


                 ....*....
gi 488378290 351 EADIIQALE 359
Cdd:PRK05613 427 IADLEGGFA 435

cysta_beta_ly_B

TIGR01324

cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ...

34-359

3.25e-44

cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]

Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 156.58 E-value: 3.25e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   34 LGESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGL 112
Cdd:TIGR01324  36 RRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAVTNsILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  113 KFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSAT 192
Cdd:TIGR01324 116 DITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGT 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  193 KYIGGHNDVLAGVVTVKDAQLAEQLNQFHNMiGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVL- 271
Cdd:TIGR01324 196 KYLVGHSDIMIGTVVANARTWDQLREHSYLM-GQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLh 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  272 ---------------YSGRTGMLSLRLNQAYS--VAKFLENLDICIFAESLGGTETFITFPYTQthvdMPDEEKDKRGID 334
Cdd:TIGR01324 275 palpscpghefwkrdFSGSSGLFSFVLQRLTQkqVHAFLDHLQLFGLGYSWGGYESLALCNQPE----LGHRPNIKRNLE 350

                         330       340
                  ....*....|....*....|....*
gi 488378290  335 EYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:TIGR01324 351 GPLIRVHIGLENVDDLKADLKAGFE 375

PRK09028

cystathionine beta-lyase; Provisional

42-359

5.79e-44

cystathionine beta-lyase; Provisional

Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 156.43 E-value: 5.79e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  42 YTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQ-LICNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFL 120
Cdd:PRK09028  55 YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISnALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPM 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 121 NYEEVEKNITPQTRALFIEpisNPQMIEIDVEPYYILSK---KHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGG 197
Cdd:PRK09028 135 IGEGIRELIRPNTKVLFLE---SPGSITMEVQDVPTLSRiahEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVG 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 198 HNDVLAGVVTVKDAQLaEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVL------ 271
Cdd:PRK09028 212 HSDVMLGTATANEKHW-DQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRhpafet 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 272 ----------YSGRTGMLSLRLNQAY--SVAKFLENLDICIFAESLGGTETFI----TFPYTQThVDMPDEEKDkrgide 335
Cdd:PRK09028 291 cpgheffkrdFSGSNGLFSFVLKQGDpkAVTALVEGMQHFKMGFSWGGFESLIlgvfGINKLRT-ATNWDFSKP------ 363

                        330       340
                 ....*....|....*....|....
gi 488378290 336 yLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK09028 364 -LIRLHIGLEDVDDLIADLEAGFE 386

PRK05967

cystathionine beta-lyase; Provisional

35-354

1.08e-42

cystathionine beta-lyase; Provisional

Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 153.04 E-value: 1.08e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  35 GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQL-ICNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLK 113
Cdd:PRK05967  51 TRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 114 FKYVDFLNYEEVEKNITPQTRALFIE-PISNPQMIEiDVEPYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSAT 192
Cdd:PRK05967 131 VEYYDPEIGAGIAKLMRPNTKVVHTEaPGSNTFEMQ-DIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAAT 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 193 KYIGGHNDVLAGVVTVkDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVL- 271
Cdd:PRK05967 210 KYPSGHSDILLGTVSA-NEKCWPQLLEAHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLh 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 272 ---------------YSGRTGMLSLRLNQAYSVAK-----FLENLDICIFAESLGGTETFitfpytQTHVDMPDEEKDKR 331
Cdd:PRK05967 289 palpsfpgheiwkrdFSGASGIFSFVLAAGPEKGKakahaFLDALEIFGLGYSWGGYESL------ALHVKLGDRTVAKA 362

                        330       340
                 ....*....|....*....|...
gi 488378290 332 GIDEYLIRLSVGIEDYNDIEADI 354
Cdd:PRK05967 363 PYAGPVIRLQIGLEDVPDLKADL 385

PRK07050

cystathionine beta-lyase; Provisional

35-359

3.22e-42

cystathionine beta-lyase; Provisional

Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 151.80 E-value: 3.22e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  35 GESTGYDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAIQLI-CNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLK 113
Cdd:PRK07050  52 RQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVyFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGIT 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 114 FKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATK 193
Cdd:PRK07050 132 VRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTK 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 194 YIGGHNDVLAGVVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVL-- 271
Cdd:PRK07050 212 YQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLhp 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 272 --------------YSGRTGMLSLRLNQAYSVAK---FLENLDICIFAESLGGTeTFITFPYTQTHvdMPDEEKDKRGid 334
Cdd:PRK07050 292 alpdcpghafwmrdFTGAGGLFSVVFDERYSPAQvdaFVEALELFAIGWSWGGA-CSLAMPYDVAS--MRTAKWPHRG-- 366

                        330       340
                 ....*....|....*....|....*
gi 488378290 335 eYLIRLSVGIEDYNDIEADIIQALE 359
Cdd:PRK07050 367 -TLVRLYIGLEDEADLIADLEQALE 390

PLN02242

methionine gamma-lyase

34-344

3.46e-39

methionine gamma-lyase

Pssm-ID: 215134 Cd Length: 418 Bit Score: 144.14 E-value: 3.46e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  34 LGESTG-YDYTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-----QLiCNifkPGDEILVAFDLYGGTFRLF-DFY 106
Cdd:PLN02242  61 LGPDRDfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAIssvllQL-CS---SGGHVVASNTLYGGTHALLaHFL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 107 EKQYGLKFKYVDFLNYEEVEKNITP-QTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFlTPYLSTPLEEGAD 185
Cdd:PLN02242 137 PRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTF-APMVLSPARLGAD 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 186 IVLHSATKYIGGHNDVLAGVVtVKDAQLAEQLNQFHN----MIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRC 261
Cdd:PLN02242 216 VVVHSISKFISGGADIIAGAV-CGPAELVNSMMDLHHgalmLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRM 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 262 RQSDSidEVLYSGRT-------------------GMLSLRLN---QAYSVAKFLENLDICIF-AESLGGTETFITFPYTQ 318
Cdd:PLN02242 295 KELGL--KVIYPGLEdhpqhallksmankgygfgGLLCLDMDteeRANRLMRYLQNSTQFGFmAVSLGYYETLMSCSGSS 372

                        330       340
                 ....*....|....*....|....*.
gi 488378290 319 THVDMPDEEKDKRGIDEYLIRLSVGI 344
Cdd:PLN02242 373 TSSELDPEEKAAAGISPGLVRMSVGY 398

PRK08114

cystathionine beta-lyase; Provisional

42-354

1.72e-29

cystathionine beta-lyase; Provisional

Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 117.11 E-value: 1.72e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  42 YTRTKNPTRTAFEEAFAQLEKGIASFATSSGMAAI-QLICNIFKPGDEILVAFDLYGGTFRLFDFYEKQYGLKFKYVDFL 120
Cdd:PRK08114  56 YGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVaNAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 121 NYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYY--ILSKKHQLLTIIDNTFLTPYLSTPLEEGADIVLHSATKYIGGH 198
Cdd:PRK08114 136 IGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIVaaVRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGH 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 199 NDVLAGvVTVKDAQLAEQLNQFHNMIGATLSPLDSYLLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVL------- 271
Cdd:PRK08114 216 SDAMIG-TAVANARCWEQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNhpalpgc 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 272 ---------YSGRTGMLSLRLNQAYS---VAKFLENLDICIFAESLGGTETFItFPYTQTHVDM--PDEEKDKRGIdeyL 337
Cdd:PRK08114 295 kghefwkrdFTGSSGLFSFVLKKKLTdeqLANYLDNFSLFSMAYSWGGFESLI-LANQPEEIAAirPAGEVDFTGT---L 370

                        330
                 ....*....|....*..
gi 488378290 338 IRLSVGIEDYNDIEADI 354
Cdd:PRK08114 371 IRLHIGLEDVDDLIADL 387

AAT_I

cd01494

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...

50-209

1.47e-10

Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 59.32 E-value: 1.47e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  50 RTAFEEAFAQLEKGIAS--FATSSGMAAIQ-LICNIFKPGDEILVafDLYGGTFRLFDFYEKQyGLKFKYVDFLN----- 121
Cdd:cd01494    2 LEELEEKLARLLQPGNDkaVFVPSGTGANEaALLALLGPGDEVIV--DANGHGSRYWVAAELA-GAKPVPVPVDDagygg 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 122 ---YEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDNTFLTPY----LSTPLEEGADIVLHSATKY 194
Cdd:cd01494   79 ldvAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKN 158

                        170
                 ....*....|....*
gi 488378290 195 IGGhndVLAGVVTVK 209
Cdd:cd01494  159 LGG---EGGGVVIVK 170

AAT_like

cd00609

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...

69-297

1.02e-08

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.

Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 56.20 E-value: 1.02e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  69 TSSGMAAIQLICNIF-KPGDEILV---AFDLYGGTFRLfdfyekqYGLKFKYV-------DFLNYEEVEKNITPQTRALF 137
Cdd:cd00609   65 TNGAQEALSLLLRALlNPGDEVLVpdpTYPGYEAAARL-------AGAEVVPVpldeeggFLLDLELLEAAKTPKTKLLY 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 138 IEPISNP--------QMIEIdVEpyyiLSKKHQLLTIIDNTFL------TPYLSTPLEEGAD--IVLHSATKYIGghndv 201
Cdd:cd00609  138 LNNPNNPtgavlseeELEEL-AE----LAKKHGILIISDEAYAelvydgEPPPALALLDAYErvIVLRSFSKTFG----- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 202 LA----GVVTVKDAQLAEQLNQFHNMIGATLSPLDSY----LLQRGLKTLHLRIERSQENAQKLAQRCRQSDSIDEVLYS 273
Cdd:cd00609  208 LPglriGYLIAPPEELLERLKKLLPYTTSGPSTLSQAaaaaALDDGEEHLEELRERYRRRRDALLEALKELGPLVVVKPS 287

                        250       260
                 ....*....|....*....|....*
gi 488378290 274 GrtGMLS-LRLNQAYSVAKFLENLD 297
Cdd:cd00609  288 G--GFFLwLDLPEGDDEEFLERLLL 310

AspB

COG0436

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...

73-210

6.85e-05

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis

Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 44.35 E-value: 6.85e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  73 MAAIQLICNifkPGDEILV---AFDLYGGTFRLFdfyekqyGLKFKYVD-------FLNYEEVEKNITPQTRALFIEPIS 142
Cdd:COG0436  104 ALALLALLN---PGDEVLVpdpGYPSYRAAVRLA-------GGKPVPVPldeengfLPDPEALEAAITPRTKAIVLNSPN 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 143 NP--------QMIEIdVEpyyiLSKKHQLLTIIDNTF--LT----PYLSTPLEEGAD---IVLHSATK----------YI 195
Cdd:COG0436  174 NPtgavysreELEAL-AE----LAREHDLLVISDEIYeeLVydgaEHVSILSLPGLKdrtIVINSFSKsyamtgwrigYA 248

                        170
                 ....*....|....*
gi 488378290 196 GGHNDVLAGVVTVKD 210
Cdd:COG0436  249 VGPPELIAALLKLQS 263

Aminotran_5

pfam00266

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...

42-300

1.62e-04

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.

Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 43.39 E-value: 1.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290   42 YTRTKNPTRtAFEEAfaqlEKGIASFA----------TSSGMAAIQLICN----IFKPGDEILVAFDLYGGTFRLFDFYE 107
Cdd:pfam00266  35 HTLGKEATQ-AYEEA----REKVAEFInapsndeiifTSGTTEAINLVALslgrSLKPGDEIVITEMEHHANLVPWQELA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  108 KQYGLKFKYVDF-----LNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPYYILSKKHQLLTIIDntFLTPYLSTPL-- 180
Cdd:pfam00266 110 KRTGARVRVLPLdedglLDLDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVD--AAQAIGHRPIdv 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290  181 -EEGADIVLHSATKYIG--GhndvlAGVVTVKDaQLAEQLNQFH---NMI------GATLSPLDS------------YLL 236
Cdd:pfam00266 188 qKLGVDFLAFSGHKLYGptG-----IGVLYGRR-DLLEKMPPLLgggGMIetvslqESTFADAPWkfeagtpniagiIGL 261

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488378290  237 QRGLKTLH-LRIERSQENAQKLAQRCRQS-DSIDEVLYSG---RTGMLSLRLNQ--AYSVAKFLENLDICI 300
Cdd:pfam00266 262 GAALEYLSeIGLEAIEKHEHELAQYLYERlLSLPGIRLYGperRASIISFNFKGvhPHDVATLLDESGIAV 332

rocD

PRK04073

ornithine--oxo-acid transaminase; Provisional

106-168

1.37e-03

ornithine--oxo-acid transaminase; Provisional

Pssm-ID: 179736 [Multi-domain] Cd Length: 396 Bit Score: 40.48 E-value: 1.37e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488378290 106 YEKQYGL---KFKYVDFLNYEEVEKNITPQTRALFIEPISNPQMIEIDVEPY----YILSKKHQLLTIID 168
Cdd:PRK04073 157 YKRGFGPmlpGIKKIPYGDLEALKAAITPNTAAFLVEPIQGEAGINIPPEGFlkaaRELCKEENVLFIAD 226

PRK06836

pyridoxal phosphate-dependent aminotransferase;

82-144

2.02e-03

pyridoxal phosphate-dependent aminotransferase;

Pssm-ID: 180720 Cd Length: 394 Bit Score: 39.79 E-value: 2.02e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488378290  82 IFKPGDEILVaFDLYggtFRLFDFYEKQYGLKFKYV-----DF-LNYEEVEKNITPQTRALFIEPISNP 144
Cdd:PRK06836 116 ILNPGDEVIV-FAPY---FVEYRFYVDNHGGKLVVVptdtdTFqPDLDALEAAITPKTKAVIINSPNNP 180

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01