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Conserved domains on  [gi|488373626|ref|WP_002443011|]
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pyrroline-5-carboxylate reductase [Staphylococcus caprae]

Protein Classification

pyrroline-5-carboxylate reductase family protein( domain architecture ID 11417420)

pyrroline-5-carboxylate reductase family protein similar to pyrroline-5-carboxylate reductase that catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline

CATH:  1.10.3730.10|3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0004735|GO:0055129

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-267 4.90e-104

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


:

Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 303.14  E-value: 4.90e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSnLGADDIYLTNKSnEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRS-PERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:COG0345   81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:COG0345  161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                        250       260
                 ....*....|....*....|....*..
gi 488373626 241 ALSQYDIVSMFEDCLGAAVNRSVELSK 267
Cdd:COG0345  241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-267 4.90e-104

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 303.14  E-value: 4.90e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSnLGADDIYLTNKSnEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRS-PERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:COG0345   81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:COG0345  161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                        250       260
                 ....*....|....*....|....*..
gi 488373626 241 ALSQYDIVSMFEDCLGAAVNRSVELSK 267
Cdd:COG0345  241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 19-264 2.89e-98

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 287.62  E-value: 2.89e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   19 IINSSNLGADDIYLTNKSNEqALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAERIKDDITEDNRFISIMAG 98
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRSPE-KLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   99 LSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVSEDHLHQVTAITGSGPAFL 178
Cdd:TIGR00112  80 VTLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  179 YHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLDALSQYDIVSMFEDCLGAA 258
Cdd:TIGR00112 160 FLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAA 239


                  ....*.
gi 488373626  259 VNRSVE 264
Cdd:TIGR00112 240 VRRSRE 245
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 1-268 1.10e-76

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 233.50  E-value: 1.10e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSsNLGADDIYLTNkSNEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:PRK11880   3 KKIGFIGGGNMASAIIGGLLAS-GVPAKDIIVSD-PSPEKRAALAEEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDIteDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEV- 159
Cdd:PRK11880  81 ELKGQL--DKLVVSIAAGVTLARLERLLGADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFGKVVWVd 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 160 SEDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGL 239
Cdd:PRK11880 159 DEKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGGTTIAAL 238

                        250       260
                 ....*....|....*....|....*....
gi 488373626 240 DALSQYDIVSMFEDCLGAAVNRSVELSKK 268
Cdd:PRK11880 239 RVLEEKGLRAAVIEAVQAAAKRSKELGKE 267
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 161-264 2.14e-33

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 117.11  E-value: 2.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 488373626  241 ALSQYDIVSMFEDCLGAAVNRSVE 264
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
 
Name Accession Description Interval E-value
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-267 4.90e-104

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 303.14  E-value: 4.90e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSnLGADDIYLTNKSnEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKSG-VPPEDIIVSDRS-PERLEALAERYGVRVTTDNAEAAAQADVVVLAVKPQDLAEVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:COG0345   81 ELAPLLDPDKLVISIAAGVTLATLEEALGGGAPVVRAMPNTPALVGEGVTALAAGEAVSEEDRELVEALFSAVGKVVWVD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:COG0345  161 EELMDAVTALSGSGPAYVFLFIEAMADAGVALGLPRETARELAAQTVLGAAKLLLESGEHPAELRDRVTSPGGTTIAGLK 240

                        250       260
                 ....*....|....*....|....*..
gi 488373626 241 ALSQYDIVSMFEDCLGAAVNRSVELSK 267
Cdd:COG0345  241 VLEEGGLRAAVIEAVEAAAERSKELGK 267
proC TIGR00112
pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline ...
 19-264 2.89e-98

pyrroline-5-carboxylate reductase; This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 272911 [Multi-domain]  Cd Length: 245  Bit Score: 287.62  E-value: 2.89e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   19 IINSSNLGADDIYLTNKSNEqALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAERIKDDITEDNRFISIMAG 98
Cdd:TIGR00112   1 LLKAGALAPYDIYVINRSPE-KLAALAKELGIVASSDAQEAVKEADVVFLAVKPQDLEEVLSELKSEKGKDKLLISIAAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   99 LSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVSEDHLHQVTAITGSGPAFL 178
Cdd:TIGR00112  80 VTLEKLSQLLGGTRRVVRVMPNTPAKVGAGVTAIAANANVSEEDRALALALFKAVGSVVELPEALMDAVTALSGSGPAYV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  179 YHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLDALSQYDIVSMFEDCLGAA 258
Cdd:TIGR00112 160 FLFIEALADAGVKQGLPRELALELAAQTVKGAAKLLEESGEHPALLKDQVTSPGGTTIAGLAVLEEKGVRGAVIEAIEAA 239


                  ....*.
gi 488373626  259 VNRSVE 264
Cdd:TIGR00112 240 VRRSRE 245
PRK11880 PRK11880
pyrroline-5-carboxylate reductase; Reviewed
 1-268 1.10e-76

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 237008 [Multi-domain]  Cd Length: 267  Bit Score: 233.50  E-value: 1.10e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSsNLGADDIYLTNkSNEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:PRK11880   3 KKIGFIGGGNMASAIIGGLLAS-GVPAKDIIVSD-PSPEKRAALAEEYGVRAATDNQEAAQEADVVVLAVKPQVMEEVLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDIteDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEV- 159
Cdd:PRK11880  81 ELKGQL--DKLVVSIAAGVTLARLERLLGADLPVVRAMPNTPALVGAGMTALTANALVSAEDRELVENLLSAFGKVVWVd 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 160 SEDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGL 239
Cdd:PRK11880 159 DEKQMDAVTAVSGSGPAYVFLFIEALADAGVKLGLPREQARKLAAQTVLGAAKLLLESGEHPAELRDNVTSPGGTTIAAL 238

                        250       260
                 ....*....|....*....|....*....
gi 488373626 240 DALSQYDIVSMFEDCLGAAVNRSVELSKK 268
Cdd:PRK11880 239 RVLEEKGLRAAVIEAVQAAAKRSKELGKE 267
PRK07679 PRK07679
pyrroline-5-carboxylate reductase; Reviewed
 1-267 1.42e-61

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 181079 [Multi-domain]  Cd Length: 279  Bit Score: 195.76  E-value: 1.42e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSNLGADDIYLTNKSNEQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDF-EALA 79
Cdd:PRK07679   4 QNISFLGAGSIAEAIIGGLLHANVVKGEQITVSNRSNETRLQELHQKYGVKGTHNKKELLTDANILFLAMKPKDVaEALI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  80 ErIKDDITEDNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEV 159
Cdd:PRK07679  84 P-FKEYIHNNQLIISLLAGVSTHSIRNLLQKDVPIIRAMPNTSAAILKSATAISPSKHATAEHIQTAKALFETIGLVSVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 160 SEDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGL 239
Cdd:PRK07679 163 EEEDMHAVTALSGSGPAYIYYVVEAMEKAAKKIGLKEDVAKSLILQTMIGAAEMLKASEKHPSILRKEITSPGGTTEAGI 242

                        250       260
                 ....*....|....*....|....*...
gi 488373626 240 DALSQYDIVSMFEDCLGAAVNRSVELSK 267
Cdd:PRK07679 243 EVLQEHRFQQALISCITQATQRSHNLGK 270
PLN02688 PLN02688
pyrroline-5-carboxylate reductase
 1-267 4.41e-53

pyrroline-5-carboxylate reductase


Pssm-ID: 178291 [Multi-domain]  Cd Length: 266  Bit Score: 173.22  E-value: 4.41e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSNLGADDIYLTNKSNeQALKDFAERLGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:PLN02688   1 FRVGFIGAGKMAEAIARGLVASGVVPPSRISTADDSN-PARRDVFQSLGVKTAASNTEVVKSSDVIILAVKPQVVKDVLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEDNRFISIMAGLSIDYIREQLNtNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:PLN02688  80 ELRPLLSKDKLLVSVAAGITLADLQEWAG-GRRVVRVMPNTPCLVGEAASVMSLGPAATADDRDLVATLFGAVGKIWVVD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:PLN02688 159 EKLLDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRDVALSLAAQTVLGAAKMVLETGKHPGQLKDMVTSPGGTTIAGVH 238

                        250       260
                 ....*....|....*....|....*..
gi 488373626 241 ALSQYDIVSMFEDCLGAAVNRSVELSK 267
Cdd:PLN02688 239 ELEKGGFRAALMNAVVAAAKRSRELSK 265
PTZ00431 PTZ00431
pyrroline carboxylate reductase; Provisional
 1-262 1.77e-37

pyrroline carboxylate reductase; Provisional


Pssm-ID: 173621 [Multi-domain]  Cd Length: 260  Bit Score: 132.77  E-value: 1.77e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSNLGADDIYLTNKSNEQAlkdfaerlGVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:PTZ00431   4 IRVGFIGLGKMGSALAYGIENSNIIGKENIYYHTPSKKNT--------PFVYLQSNEELAKTCDIIVLAVKPDLAGKVLL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEdNRFISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:PTZ00431  76 EIKPYLGS-KLLISICGGLNLKTLEEMVGVEAKIVRVMPNTPSLVGQGSLVFCANNNVDSTDKKKVIDIFSACGIIQEIK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:PTZ00431 155 EKDMDIATAISGCGPAYVFLFIESLIDAGVKNGLNRDVSKNLVLQTILGSVHMVKASDQPVQQLKDDVCSPGGITIVGLY 234

                        250       260
                 ....*....|....*....|..
gi 488373626 241 ALSQYDIVSMFEDCLGAAVNRS 262
Cdd:PTZ00431 235 TLEKHAFKYTVMDAVESACQKS 256
P5CR_dimer pfam14748
Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of ...
 161-264 2.14e-33

Pyrroline-5-carboxylate reductase dimerization; Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (pfam03807) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 464294 [Multi-domain]  Cd Length: 104  Bit Score: 117.11  E-value: 2.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  161 EDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLD 240
Cdd:pfam14748   1 ESLMDAVTALSGSGPAYVFLFIEALADAGVAMGLPREEARELAAQTVLGAAKLLLTSGEHPAELRDKVTSPGGTTIAGLA 80

                          90       100
                  ....*....|....*....|....
gi 488373626  241 ALSQYDIVSMFEDCLGAAVNRSVE 264
Cdd:pfam14748  81 VLEEGGFRGAVIEAVEAATKRAKE 104
PRK06928 PRK06928
pyrroline-5-carboxylate reductase; Reviewed
 2-271 1.52e-28

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235888 [Multi-domain]  Cd Length: 277  Bit Score: 109.86  E-value: 1.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   2 KLVFYGAGNMAQAIFTGIINSSNLGADDIYLTNKSNEQALKDFAERL-GVNYSYDDAELLKDADYVFLGTKPHDFEALAE 80
Cdd:PRK06928   3 KIGFIGYGSMADMIATKLLETEVATPEEIILYSSSKNEHFNQLYDKYpTVELADNEAEIFTKCDHSFICVPPLAVLPLLK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  81 RIKDDITEDNRFISIMAGLSIDYIREqLNTNNPLARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVIEVS 160
Cdd:PRK06928  83 DCAPVLTPDRHVVSIAAGVSLDDLLE-ITPGLQVSRLIPSLTSAVGVGTSLVAHAETVNEANKSRLEETLSHFSHVMTIR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 161 EDHLHQVTAITGSGPAFLYHVFEQYVKAG---TELGLErdQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQA 237
Cdd:PRK06928 162 EENMDIASNLTSSSPGFIAAIFEEFAEAAvrnSSLSDE--EAFQFLNFALAGTGKLLVEEDYTFSGTIERVATKGGITAE 239

                        250       260       270
                 ....*....|....*....|....*....|....
gi 488373626 238 GLDaLSQYDIVSMFEDCLgAAVNRSVELSKKESE 271
Cdd:PRK06928 240 GAE-VIQAQLPQFFDELL-DRTQKKYASSKKEIQ 271
PRK07680 PRK07680
late competence protein ComER; Validated
 1-252 7.90e-28

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 107.75  E-value: 7.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIINSSNLGADDIYLTNKSNEQALKdFAERL-GVNYSYDDAELLKDADYVFLGTKPHDFEALA 79
Cdd:PRK07680   1 MNIGFIGTGNMGTILIEAFLESGAVKPSQLTITNRTPAKAYH-IKERYpGIHVAKTIEEVISQSDLIFICVKPLDIYPLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  80 ERIKDDITEDNRFISIMAGLSIdyirEQLNTNNP--LARIMPNTNAQVGHSVTGISFSNNFGPKSKDEVNELVNAFGSVI 157
Cdd:PRK07680  80 QKLAPHLTDEHCLVSITSPISV----EQLETLVPcqVARIIPSITNRALSGASLFTFGSRCSEEDQQKLERLFSNISTPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 158 EVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGT-ELGLERDQVEESIRNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQ 236
Cdd:PRK07680 156 VIEEDITRVSSDIVSCGPAFFSYLLQRFIDAAVeETNISKEEATTLASEMLIGMGKLLEKGLYTLPTLQEKVCVKGGITG 235

                        250
                 ....*....|....*.
gi 488373626 237 AGLDALSQyDIVSMFE 252
Cdd:PRK07680 236 EGIKVLEE-EVGDMFH 250
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
5-98 3.40e-13

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 63.79  E-value: 3.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626    5 FYGAGNMAQAIFTGIINSsnlGADDIYLTNKSNEQALKDFAERLGVNYS-YDDAELLKDADYVFLGTKPHDFEALAERIK 83
Cdd:pfam03807   2 FIGAGNMGEALARGLVAA---GPHEVVVANSRNPEKAEELAEEYGVGATaVDNEEAAEEADVVFLAVKPEDAPDVLSELS 78

                          90
                  ....*....|....*
gi 488373626   84 DDItEDNRFISIMAG 98
Cdd:pfam03807  79 DLL-KGKIVISIAAG 92
PRK06476 PRK06476
pyrroline-5-carboxylate reductase; Reviewed
 1-261 7.18e-12

pyrroline-5-carboxylate reductase; Reviewed


Pssm-ID: 235812 [Multi-domain]  Cd Length: 258  Bit Score: 63.88  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626   1 MKLVFYGAGNMAQAIFTGIInSSNLGADDIYLTNKSneqalKDFAERLGVNY-----SYDDAELLKDADYVFLGTKPhdf 75
Cdd:PRK06476   1 MKIGFIGTGAITEAMVTGLL-TSPADVSEIIVSPRN-----AQIAARLAERFpkvriAKDNQAVVDRSDVVFLAVRP--- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626  76 ealaeRIKDDITEDNRF------ISIMAGLSIDYIREQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFgpkskdeVNEL 149
Cdd:PRK06476  72 -----QIAEEVLRALRFrpgqtvISVIAATDRAALLEWIGHDVKLVRAIPLPFVAERKGVTAIYPPDPF-------VAAL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488373626 150 VNAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERDQVEESIRNLIIG-TSKMIERSDLSMEQLRKNI 228
Cdd:PRK06476 140 FDALGTAVECDSEEEYDLLAAASALMATYFGILETATGWLEEQGLKRQKARAYLAPLFASlAQDAVRSTKTDFSALSREF 219

                        250       260       270
                 ....*....|....*....|....*....|...
gi 488373626 229 TSKGGTTQAGLDALSQYDIVSMFEDCLGAAVNR 261
Cdd:PRK06476 220 STKGGLNEQVLNDFSRQGGYAALTDALDRVLRR 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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