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Conserved domains on  [gi|488266250|ref|WP_002337458|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10054599)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 8-60 6.38e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 6.38e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILDI 60
Cdd:cd00093   3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS-----LETLEKLAKA 50
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 8-60 6.38e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 6.38e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILDI 60
Cdd:cd00093   3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS-----LETLEKLAKA 50
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-59 9.39e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.57  E-value: 9.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488266250    8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILD 59
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS-----LETLKKLAK 47
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
8-42 9.71e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.13  E-value: 9.71e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNR 42
Cdd:COG1396  11 RLRELRKARGLTQEELAERLGVSRSTISRIERGRR 45
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 9-40 1.56e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 32.89  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 488266250   9 IRAEMRKRRMTFKELAALVGISGAYLSDILNG 40
Cdd:pfam13560  6 LRRLRERAGLSQEALARRLGVSRSTLSRLETG 37
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 8-60 6.38e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.99  E-value: 6.38e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILDI 60
Cdd:cd00093   3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS-----LETLEKLAKA 50
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-59 9.39e-05

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.57  E-value: 9.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488266250    8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILD 59
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS-----LETLKKLAK 47
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
8-42 9.71e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.13  E-value: 9.71e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNGNR 42
Cdd:COG1396  11 RLRELRKARGLTQEELAERLGVSRSTISRIERGRR 45
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-60 4.49e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.05  E-value: 4.49e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488266250  1 MSENLDLKIRAEMRKRRMTFKELAALVGISGAYLSDILNGNRDGKkaqqhIETVKKILDI 60
Cdd:COG1476   1 MKKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS-----LELALKIARA 55
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 9-40 1.56e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 32.89  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 488266250   9 IRAEMRKRRMTFKELAALVGISGAYLSDILNG 40
Cdd:pfam13560  6 LRRLRERAGLSQEALARRLGVSRSTLSRLETG 37
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 3-42 4.71e-03

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 31.45  E-value: 4.71e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 488266250  3 ENLDLKIRAEMRKRRMTFKELAALVGISGAYLSDILNGNR 42
Cdd:COG1813  11 EDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEA 50
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 9-60 5.46e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 30.97  E-value: 5.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488266250   9 IRAEMRKRRMTFKELAALVGISGAYLSDILNGnrdgkKAQQHIETVKKILDI 60
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENG-----KREPSLETLKKLAEA 47
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
8-40 7.32e-03

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 30.88  E-value: 7.32e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 488266250  8 KIRAEMRKRRMTFKELAALVGISGAYLSDILNG 40
Cdd:COG3655   5 KLDELLAERGMTKKELAEATGISRATLSRLKNG 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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