NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488261292|ref|WP_002332500|]
View 

ROK family protein [Enterococcus faecium]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 9-293 2.70e-74

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24152:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 286  Bit Score: 229.38  E-value: 2.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSAlIMDTQ--IREKRQIETPKTDKDNFILVLVELIRSYQqiEPIEFVGFSVPGAV-KEASTVFFGGAVA 85
Cdd:cd24152    3 LVFDIGGTFIKYA-LVDENgnIIKKGKIPTPKDSLEEFLDYIKKIIKRYD--EEIDGIAISAPGVIdPETGIIYGGGALP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:cd24152   80 YLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 166 rGINGAESFAGINLSAVRLVKELTKLFQCEPE-GPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLDKIIIGG 244
Cdd:cd24152  160 -DDDKDLLFFSGLASMFGLVKRYNKAKGLEPLdGEEIFE-KYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488261292 245 GISKQKRLIRDIQKNYEAIFSVSPmieQTITKMTIEAAAFESEANLIGA 293
Cdd:cd24152  238 GISEQPLFIEDLKKEVNEILANRP---GSIPKPEIKACKFGNDANLLGA 283
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 9-293 2.70e-74

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 229.38  E-value: 2.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSAlIMDTQ--IREKRQIETPKTDKDNFILVLVELIRSYQqiEPIEFVGFSVPGAV-KEASTVFFGGAVA 85
Cdd:cd24152    3 LVFDIGGTFIKYA-LVDENgnIIKKGKIPTPKDSLEEFLDYIKKIIKRYD--EEIDGIAISAPGVIdPETGIIYGGGALP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:cd24152   80 YLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 166 rGINGAESFAGINLSAVRLVKELTKLFQCEPE-GPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLDKIIIGG 244
Cdd:cd24152  160 -DDDKDLLFFSGLASMFGLVKRYNKAKGLEPLdGEEIFE-KYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488261292 245 GISKQKRLIRDIQKNYEAIFSVSPmieQTITKMTIEAAAFESEANLIGA 293
Cdd:cd24152  238 GISEQPLFIEDLKKEVNEILANRP---GSIPKPEIKACKFGNDANLLGA 283
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 6-294 4.93e-60

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 193.57  E-value: 4.93e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTLSIDIGGTYIKSALI-MDTQIREKRQIETPK-TDKDNFILVLVELIRSYQQ-----IEPIEFVGFSVPGAV-KEAST 77
Cdd:COG1940    5 GYVIGIDIGGTKIKAALVdLDGEVLARERIPTPAgAGPEAVLEAIAELIEELLAeagisRGRILGIGIGVPGPVdPETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  78 VFFGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAG 157
Cdd:COG1940   85 VLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 158 EVSFLIQDR-------GING-AESFAginlSAVRLVKELTKLFQCEP-EGPLVFDyLYQKEDDQAQTLYRTYCNQVAILC 228
Cdd:COG1940  165 EIGHMPVDPdgplcgcGNRGcLETYA----SGPALLRRARELGGAEKlTAEELFA-AARAGDPLALEVLDEAARYLGIGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488261292 229 FNIQCLLDLDKIIIGGGISKQ-KRLIRDIQKNYEAiFSVSPMIEQTitkmTIEAAAFESEANLIGAA 294
Cdd:COG1940  240 ANLINLLDPEVIVLGGGVSAAgDLLLEPIREALAK-YALPPAREDP----RIVPASLGDDAGLLGAA 301
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 9-294 2.00e-28

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 110.89  E-value: 2.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292    9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTD-KDNFILVLVELIRSYQQ-IEPIEFVGFSVPGAVKEASTVFFGGAVA 85
Cdd:pfam00480   1 IGIDIGGTKIAAALFdEEGEILARERVPTPTTTtEETLVDAIAFFVDSAQRkFGELIAVGIGSPGLISPKYGYITNTPNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:pfam00480  81 GWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  166 RgiNGAESFAG------INLSAVRLVKEL-TKLFQCEPEGPLVfdyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLD 238
Cdd:pfam00480 161 P--NGPKCGCGnhgcleTIASGRALEKRYqQKGEDLEGKDIIV---LAEQGDEVAEEAVERLARYLAKAIANLINLFDPQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  239 KIIIGGGISKQKRLIRDIQKNYEAI----FSVSPMIeqtitkmtIEAAAFESEANLIGAA 294
Cdd:pfam00480 236 AIVLGGGVSNADGLLEAIRSLVKKYlngyLPVPPVI--------IVAASLGDNAGALGAA 287
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 9-294 2.21e-25

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 103.06  E-value: 2.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292    9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTDkDNFILVLVELIRSYQQI-----EPIEFVGFSVPGAV-KEASTVFFG 81
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVdEEGNILSKWKVPTDTTP-ETIVDAIASAVDSFIQHiakvgHEIVAIGIGAPGPVnRQRGTVYFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   82 GAVACLNEVnLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSF 161
Cdd:TIGR00744  80 VNLDWKQEP-LKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  162 L--IQDRG----------INGAESFAGInlsaVRLVK----------ELTKLFQCEP-EGPLVFDylYQKEDDQ-AQTLY 217
Cdd:TIGR00744 159 IrmVPDGRllcncgkqgcIETYASATGL----VRYAKranakperaeVLLALGDGDGiSAKHVFV--AARQGDPvAVDSY 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488261292  218 RTYCNQVAILCFNIQCLLDLDKIIIGGGISKQKRLIRD-IQKNYEAiFSVSPMIEQTitkmTIEAAAFESEANLIGAA 294
Cdd:TIGR00744 233 REVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDpIRKSYKR-WLFGGARQVA----DIIAAQLGNDAGLVGAA 305
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 6-294 6.70e-24

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 98.45  E-value: 6.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTLSIDIGGTYIKSALIM-DTQIREKRQIETPKT-DKDNFILVLVELIRSYQQiePIEFVGFSVPGAVKEastvffgGA 83
Cdd:PRK05082   1 MTTLAIDIGGTKIAAALVGeDGQIRQRRQIPTPASqTPEALRQALSALVSPLQA--QADRVAVASTGIIND-------GI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  84 VACLNEVNL--------KQEIEKHLPVRVFVENDAKAAVLGEasFGHLKG-IENGAGIILGTGVGVGLLLDGQVRKGPHC 154
Cdd:PRK05082  72 LTALNPHNLggllhfplVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDdIRNMVFITVSTGVGGGIVLNGKLLTGPGG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 155 QAGEVSFLIQDrgINGA----------ESFA---GINLSAvrlvkeLTKLFQCEPEgpLVFDyLYQKEDDQAQTLYRTYC 221
Cdd:PRK05082 150 LAGHIGHTLAD--PHGPvcgcgrrgcvEAIAsgrAIAAAA------QGWLAGCDAK--TIFE-RAGQGDEQAQALINRSA 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488261292 222 NQVAILCFNIQCLLDLDKIIIGGGISKQK---RLIRDIQKNYEAIFSVspmieqtitkmTIEAAAFESEANLIGAA 294
Cdd:PRK05082 219 QAIARLIADLKATLDCQCVVLGGSVGLAEgylELVQAYLAQEPAIYHV-----------PLLAAHYRHDAGLLGAA 283
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 9-293 2.70e-74

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 229.38  E-value: 2.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSAlIMDTQ--IREKRQIETPKTDKDNFILVLVELIRSYQqiEPIEFVGFSVPGAV-KEASTVFFGGAVA 85
Cdd:cd24152    3 LVFDIGGTFIKYA-LVDENgnIIKKGKIPTPKDSLEEFLDYIKKIIKRYD--EEIDGIAISAPGVIdPETGIIYGGGALP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:cd24152   80 YLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 166 rGINGAESFAGINLSAVRLVKELTKLFQCEPE-GPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLDKIIIGG 244
Cdd:cd24152  160 -DDDKDLLFFSGLASMFGLVKRYNKAKGLEPLdGEEIFE-KYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGG 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488261292 245 GISKQKRLIRDIQKNYEAIFSVSPmieQTITKMTIEAAAFESEANLIGA 293
Cdd:cd24152  238 GISEQPLFIEDLKKEVNEILANRP---GSIPKPEIKACKFGNDANLLGA 283
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 6-294 4.93e-60

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 193.57  E-value: 4.93e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTLSIDIGGTYIKSALI-MDTQIREKRQIETPK-TDKDNFILVLVELIRSYQQ-----IEPIEFVGFSVPGAV-KEAST 77
Cdd:COG1940    5 GYVIGIDIGGTKIKAALVdLDGEVLARERIPTPAgAGPEAVLEAIAELIEELLAeagisRGRILGIGIGVPGPVdPETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  78 VFFGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAG 157
Cdd:COG1940   85 VLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGNAG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 158 EVSFLIQDR-------GING-AESFAginlSAVRLVKELTKLFQCEP-EGPLVFDyLYQKEDDQAQTLYRTYCNQVAILC 228
Cdd:COG1940  165 EIGHMPVDPdgplcgcGNRGcLETYA----SGPALLRRARELGGAEKlTAEELFA-AARAGDPLALEVLDEAARYLGIGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488261292 229 FNIQCLLDLDKIIIGGGISKQ-KRLIRDIQKNYEAiFSVSPMIEQTitkmTIEAAAFESEANLIGAA 294
Cdd:COG1940  240 ANLINLLDPEVIVLGGGVSAAgDLLLEPIREALAK-YALPPAREDP----RIVPASLGDDAGLLGAA 301
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 9-295 8.15e-44

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 151.17  E-value: 8.15e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALIMDT-QIREKRQIETPKTDKDNFILV-LVELIRSYQQIEPIEFVGFSVPGAV--KEASTVFFGGAV 84
Cdd:cd24068    3 LGIDIGGTKIKYGLVDADgEILEKDSVPTPASKGGDAILErLLEIIAELKEKYDIEGIGISSAGQVdpKTGEVIYATDNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  85 ACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFL-I 163
Cdd:cd24068   83 PGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMvV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 164 QDRGINGAESFAGI-----NLSA-VRLVKELTKLFQCEPEgpLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDL 237
Cdd:cd24068  163 DPGGRPCCCGGKGCleqyaSGTAlVRRVAEALGEPGIDGR--EIFD-LADAGDPLAKEVVEEFAEDLATGLANLVHIFDP 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488261292 238 DKIIIGGGISKQK-RLIRDIQKNYEAIFsvspmIEQTITKMTIEAAAFESEANLIGAAK 295
Cdd:cd24068  240 EVIVIGGGISAQGeLFLEELREELRKLL-----MPPLLDATKIEPAKLGNDAGLLGAAY 293
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 9-294 5.38e-38

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 134.51  E-value: 5.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKT-DKDNFILVLVELIRSYQQ----IEPIEFVGFSVPGAV-KEASTVFFG 81
Cdd:cd23763    1 IGIDIGGTKIRAALVdLDGEILARERVPTPAEeGPEAVLDRIAELIEELLAeagvRERILGIGIGVPGPVdPETGIVLFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  82 GAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSF 161
Cdd:cd23763   81 PNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIGH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 162 LiqdrgingaesfaginlsavrlvkeltklfqcepegplvfdylyqkeddqaqTLYRTYCNQVAILCFNIQCLLDLDKII 241
Cdd:cd23763  161 I----------------------------------------------------TVLEEAARYLGIGLANLINLLNPELIV 188

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488261292 242 IGGGISKQKRLIRDIQKNYEAIFSVSPMIEQTitkmTIEAAAFESEANLIGAA 294
Cdd:cd23763  189 LGGGVAEAGDLLLEPIREAVRRRALPPLRRRV----RIVPSELGDDAGLLGAA 237
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 9-294 2.97e-33

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 123.16  E-value: 2.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALIMDTQIREKRQIETPKT-DKDNFILVLVELIRSYQqiEPIEFVGFSVPGAVKEAS-TVFFGGAVAC 86
Cdd:cd24069    1 LAIDIGGTKIAAALIGNGQIIDRRQIPTPRSgTPEALADALASLLADYQ--GQFDRVAVASTGIIRDGVlTALNPKNLGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  87 LNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQDR 166
Cdd:cd24069   79 LSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 167 G--------INGAESFAGINLSAVRLVKELTKLFQCepegPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLD 238
Cdd:cd24069  159 PgpvcgcgrRGCVEAIASGTAIAAAASEILGEPVDA----KDVFE-RARSGDEEAARLIDRAARALADLIADLKATLDLD 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488261292 239 KIIIGGGI---SKQKRLIRDIQKNYEAIFSVSpmieqtitkmtIEAAAFESEANLIGAA 294
Cdd:cd24069  234 CVVIGGSVglaEGFLERVEQYLADEPAIFRVS-----------LEPARLGQDAGLLGAA 281
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 7-295 7.23e-33

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 123.17  E-value: 7.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   7 WTLSIDIGGTYIKSALI-MDTQIREKRQIETPKTDKDNFILVlvELIRSYQQI--------EPIEFVGFSVPGAVKEAST 77
Cdd:cd24062    1 WIVGIDVGGTTIKMAFLtQEGEIVQKWEIPTNKLEGGENIIT--DIAESIQQLleelgyskEDLIGIGVGVPGPVDVETG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  78 VFFGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAG 157
Cdd:cd24062   79 TVEVAVNLGWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 158 EVSFLIQDR--------GINGA-ESFA---GINLSAVRLVKE---LTKLFQCEPEGPL----VFDyLYQKEDDQAQTLYR 218
Cdd:cd24062  159 EIGHITVNPeggapcncGKTGClETVAsatGIVRIAREELEEgkgSSALRILALGGELtakdVFE-AAKAGDELALAVVD 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488261292 219 TYCNQVAILCFNIQCLLDLDKIIIGGGISKQKRLIRDIQKNYEAIFSVSpmieQTITKMTIEAAAFESEANLIGAAK 295
Cdd:cd24062  238 TVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFP----RVRQDTEIVLATLGNDAGVIGAAW 310
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 8-294 3.02e-32

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 3.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   8 TLSIDIGGTYIKSALIMDTQIREKRQIETPKTDKDNFILVLVELIRSYQQIEP-IEFVGFSVPGAVK-EASTVFFGGAVA 85
Cdd:cd24065    2 TIGLDLGGTKIAAGVVDGGRILSRLVVPTPREGGEAVLDALARAVEALQAEAPgVEAVGLGVPGPLDfRRGRVRFAPNIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLI-- 163
Cdd:cd24065   82 GLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTvl 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 164 -----QDRGINGA-ESFAginlSAVRLVKELTKLFQCEPEGPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDL 237
Cdd:cd24065  162 pggpmCGCGLVGClEALA----SGRALARDASFAYGRPMSTAELFE-LAQQGEPKALRIVEQAAAHLGIGLANLQKALDP 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488261292 238 DKIIIGGGISKQkrlirdiqknyeAIFSVSPMIE------QTITKMTIEAAAFESEANLIGAA 294
Cdd:cd24065  237 EVFVLGGGVAQV------------GDYYLLPVQEaarrytEGWHAPPLRLAHLGTDAGVIGAA 287
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 6-294 2.86e-31

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 118.49  E-value: 2.86e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTlSIDIGGTYIKSALI-MDTQIREKRQIETPKTDKDNFILVLVELIRSYQQIEPI-EFVGFSVPGAVKEASTVFFGGA 83
Cdd:cd24057    1 MYY-GFDIGGTKIEFAVFdEALQLVWTKRVPTPTDDYAAFLAAIAELVAEADARFGVkGPVGIGIPGVIDPEDGTLITAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  84 VACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFL- 162
Cdd:cd24057   80 IPAAKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGEWGHGp 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 163 ----------------------------IQDRGING-AESFAGINLSAVRLVKeltklfqcepegplvfdyLYQKEDDQA 213
Cdd:cd24057  160 lpadalllgydlpvlrcgcgqtgcletyLSGRGLERlYAHLYGEELDAPEIIA------------------AWAAGDPQA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 214 QTLYRTYCNQVAILCFNIQCLLDLDKIIIGGGISKQKRLIRDIQKNYEA-IFSVspmieqtITKMTIEAAAFESEANLIG 292
Cdd:cd24057  222 VAHVDRWLDLLAGCLANILTALDPDVVVLGGGLSNFPALIAELPAALPAhLLSG-------ARTPRIVPARHGDAGGVRG 294


                 ..
gi 488261292 293 AA 294
Cdd:cd24057  295 AA 296
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 9-294 2.00e-28

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 110.89  E-value: 2.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292    9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTD-KDNFILVLVELIRSYQQ-IEPIEFVGFSVPGAVKEASTVFFGGAVA 85
Cdd:pfam00480   1 IGIDIGGTKIAAALFdEEGEILARERVPTPTTTtEETLVDAIAFFVDSAQRkFGELIAVGIGSPGLISPKYGYITNTPNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:pfam00480  81 GWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  166 RgiNGAESFAG------INLSAVRLVKEL-TKLFQCEPEGPLVfdyLYQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLD 238
Cdd:pfam00480 161 P--NGPKCGCGnhgcleTIASGRALEKRYqQKGEDLEGKDIIV---LAEQGDEVAEEAVERLARYLAKAIANLINLFDPQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  239 KIIIGGGISKQKRLIRDIQKNYEAI----FSVSPMIeqtitkmtIEAAAFESEANLIGAA 294
Cdd:pfam00480 236 AIVLGGGVSNADGLLEAIRSLVKKYlngyLPVPPVI--------IVAASLGDNAGALGAA 287
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 11-294 2.05e-25

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 102.80  E-value: 2.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  11 IDIGGTYIKSALI-MDTQIREKRQIETPKT-DKDNFILVLVELIR---SYQQIEPIEFVGFSVPGAVKEASTVFFGGAVA 85
Cdd:cd24063    5 VDIGGTWIRAGLVdEDGRILLKIRQPTPKTgDPGTVSEQVLGLIEtllSKAGKDSIEGIGVSSAGPLDLRKGTIVNSPNI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:cd24063   85 KGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGHLVVD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 166 RGINGA---------ESFAG-----------INLSAVRLVKELTKLFQCEPEGPLVFDyLYQKEDDQAQTLYRTYCNQVA 225
Cdd:cd24063  165 TESGLKcgcggyghwEAFASgrgiprfarewAEGFSSRTSLKLRNPGGEGITAKEVFS-AARKGDPLALKIIEKLARYNG 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 226 ILCFNIQCLLDLDKIIIGGGISK-QKRLIRDIQKNYEAIFSVSPMIEqtitkmtIEAAAFESEANLIGAA 294
Cdd:cd24063  244 RGIANVINAYDPELIVIGGSVFNnNKDILDPLIEYLEKNPAISKGPE-------IVLSELGDDVGLIGAL 306
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 9-294 2.21e-25

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 103.06  E-value: 2.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292    9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTDkDNFILVLVELIRSYQQI-----EPIEFVGFSVPGAV-KEASTVFFG 81
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVdEEGNILSKWKVPTDTTP-ETIVDAIASAVDSFIQHiakvgHEIVAIGIGAPGPVnRQRGTVYFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   82 GAVACLNEVnLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSF 161
Cdd:TIGR00744  80 VNLDWKQEP-LKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  162 L--IQDRG----------INGAESFAGInlsaVRLVK----------ELTKLFQCEP-EGPLVFDylYQKEDDQ-AQTLY 217
Cdd:TIGR00744 159 IrmVPDGRllcncgkqgcIETYASATGL----VRYAKranakperaeVLLALGDGDGiSAKHVFV--AARQGDPvAVDSY 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488261292  218 RTYCNQVAILCFNIQCLLDLDKIIIGGGISKQKRLIRD-IQKNYEAiFSVSPMIEQTitkmTIEAAAFESEANLIGAA 294
Cdd:TIGR00744 233 REVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDpIRKSYKR-WLFGGARQVA----DIIAAQLGNDAGLVGAA 305
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 8-294 2.07e-24

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 100.12  E-value: 2.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   8 TLSIDIGGTYIKSALIMDT-QIREKRQIETPKtDKDNFILVLVELIRSYQQIEPIEFVGFSVPGAV-KEASTVFFGGAVA 85
Cdd:cd24061    1 TIGVDIGGTKIAAGVVDEEgEILATERVPTPP-TADGIVDAIVEAVEELREGHDVSAVGVAAAGFVdADRATVLFAPNIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEvNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFL--I 163
Cdd:cd24061   80 WRNE-PLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIrvV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 164 QDR-----GINGA-ESFAginlSAVRLVKELTKLFQCEPEGPLVfdyLYQKEDDQ-----------------AQTLYRTY 220
Cdd:cd24061  159 PDGllcgcGSRGCwEQYA----SGRALVRYAKEAANATPEGAAV---LLADGSVDgitgkhiseaaragdpvALDALREL 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488261292 221 CNQVAILCFNIQCLLDLDKIIIGGGISKQKRLIRD-IQKNYEAIFSVSPmieqTITKMTIEAAAFESEANLIGAA 294
Cdd:cd24061  232 ARWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDpIREAFERWLPGRG----WRPIPRLRTAQLGNDAGLIGAA 302
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 6-294 6.70e-24

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 98.45  E-value: 6.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTLSIDIGGTYIKSALIM-DTQIREKRQIETPKT-DKDNFILVLVELIRSYQQiePIEFVGFSVPGAVKEastvffgGA 83
Cdd:PRK05082   1 MTTLAIDIGGTKIAAALVGeDGQIRQRRQIPTPASqTPEALRQALSALVSPLQA--QADRVAVASTGIIND-------GI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  84 VACLNEVNL--------KQEIEKHLPVRVFVENDAKAAVLGEasFGHLKG-IENGAGIILGTGVGVGLLLDGQVRKGPHC 154
Cdd:PRK05082  72 LTALNPHNLggllhfplVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDdIRNMVFITVSTGVGGGIVLNGKLLTGPGG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 155 QAGEVSFLIQDrgINGA----------ESFA---GINLSAvrlvkeLTKLFQCEPEgpLVFDyLYQKEDDQAQTLYRTYC 221
Cdd:PRK05082 150 LAGHIGHTLAD--PHGPvcgcgrrgcvEAIAsgrAIAAAA------QGWLAGCDAK--TIFE-RAGQGDEQAQALINRSA 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488261292 222 NQVAILCFNIQCLLDLDKIIIGGGISKQK---RLIRDIQKNYEAIFSVspmieqtitkmTIEAAAFESEANLIGAA 294
Cdd:PRK05082 219 QAIARLIADLKATLDCQCVVLGGSVGLAEgylELVQAYLAQEPAIYHV-----------PLLAAHYRHDAGLLGAA 283
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 6-294 2.89e-21

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 91.46  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   6 MWTLSIDIGGTYIKSALIMDTQIREKRQIETPKT--DKDNFILVLVELIRSY--QQIEPIEFVGFSVPGAV-KEASTVFF 80
Cdd:cd24070    1 KYVLGIDIGGTNIRIGLVDEDGKLLDFEKVPSKDllRAGDPVEVLADLIREYieEAGLKPAAIVIGVPGTVdKDRRTVIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  81 GGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGE-- 158
Cdd:cd24070   81 TPNIPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAGElg 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 159 -VSFLIQDR-----GINGAESFA-GINLsaVRLVKE------LTKLFQCEPEGPLVFDYLyqkeDDQAqtlyRTYCNQVA 225
Cdd:cd24070  161 hIPVYGNGKpcgcgNTGCLETYAsGRAL--EEIAEEhypdtpILDIFVDHGDEPELDEFV----EDLA----LAIATEIN 230

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488261292 226 IlcfniqclLDLDKIIIGGGISK-----QKRLIRDIQKNyeaifSVSPMIEQTItkmTIEAAAFESEANLIGAA 294
Cdd:cd24070  231 I--------LDPDAVILGGGVIDmkgfpRETLEEYIRKH-----LRKPYPADNL---KIIYAELGPEAGVIGAA 288
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 9-265 3.28e-21

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 91.11  E-value: 3.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKsALIMDTQIRE--KRQIETPKTDKDNFILVLVELI-RSYQQIEPIEFVGFSVPGA-------VKEASTV 78
Cdd:cd24066    2 IGIDLGGTKIE-GIALDRAGREllRRRVPTPRGDYEATLDAIADLVeEAEEELGAPATVGIGTPGSisprtglVKNANST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  79 ffggavaCLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGE 158
Cdd:cd24066   81 -------WLNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 159 VSFLI----QDRGINGAESFAGIN------LSAVRLVKELTKLFQCEPEGPLVFDyLYQKEDDQAQTLYRTYCNQVAILC 228
Cdd:cd24066  154 WGHNPlpwpDEDELPGPPCYCGKRgcvetfLSGPALERDYARLTGKTLSAEEIVA-LARAGDAAAVATLDRFLDRLGRAL 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 488261292 229 FNIQCLLDLDKIIIGGGISKQKRLIRD-IQKNYEAIFS 265
Cdd:cd24066  233 ANVINILDPDVIVLGGGLSNIDELYTEgPAALARYVFS 270
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 8-294 1.77e-20

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 89.18  E-value: 1.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   8 TLSIDIGGTYIKSALI-MDTQIREKRQIETP-KTDKDNFILVLVELIRSYQQIEPIEF----VGFSVPGAVKEASTV--- 78
Cdd:cd24059    3 VIGVEIGRDLLSAVLCdLSGNILAREKYPLDeKENPEEVLEKLYELIDRLLEKENIKSkilgIGIGAPGPLDVEKGIiln 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  79 ---FFGGavaclNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQ 155
Cdd:cd24059   83 ppnFPGW-----ENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 156 AGEVSFLIQDrgINGA----------ESFAGINlsavRLVKELTKLFQCEPEGPLVFDYLYQKEDDQAQTLYRTYCNQVA 225
Cdd:cd24059  158 AGEIGHTSID--INGPrcscgnrgclELYASIP----AIEKKARSALGSGRSFQLDIVEALQKGDPIADEVIEEAAKYLG 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 226 ILCFNIQCLLDLDKIIIGG-GISKQKRLIRDIQKNYEaifsvSPMIEQTITKMTIEAAAFESEANLIGAA 294
Cdd:cd24059  232 IGLVNLINLLNPEAIIIGGeLIYLGERYLEPIEKEVN-----SRLFGRNAREVRILKSSLGEDAPLLGAA 296
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 7-294 2.37e-20

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 89.01  E-value: 2.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   7 WTLSIDIGGTYIKSALI-MDTQIREKRQIETPKTDKDNFILVLVELIRSYQQIEP----IEFVGFSVPGAV--KEASTVF 79
Cdd:cd24060    1 SALAVDLGGTNLRVAIVsMKGEIVKKYTQPNPKTYEERIDLILQMCVEAASEAVKlncrILGVGISTGGRVnpREGIVLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  80 FGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEV 159
Cdd:cd24060   81 STKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCAAEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 160 SFLIQDR-------GINGA-ESFAginlSAVRLVKELTKLFQcepEGPLVFDYLYQKEDDQ----------------AQT 215
Cdd:cd24060  161 GHIVVSLdgpdcmcGSHGCvEAYA----SGMALQREAKKLHD---EDLLLVEGMSVTNDEEvtakhliqaaklgnakAQK 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 216 LYRTYCNQVAILCFNIQCLLDLDKIIIGGGISKQkrlirdiqknYEAIfsVSPMIEQTITKMTIEAAAFES---EANLIG 292
Cdd:cd24060  234 ILRTAGTALGLGIVNILHTLNPSLVILSGVLASH----------YENI--VKDVIAQRALPSVQNVDVVVSdlvDPALLG 301


                 ..
gi 488261292 293 AA 294
Cdd:cd24060  302 AA 303
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 9-294 2.03e-19

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 86.47  E-value: 2.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTDK-DNFILVLVELIRSYQQIEP-----IEFVGFSVPGAV-KEASTVFF 80
Cdd:cd24076    4 IGVELGVDYITVVVTdLAGEVLWRREVPLPASDDpDEVLAQLAALIREALAAAPdsplgILGIGVGVPGLVdSEDGVVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  81 ----GgavacLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQA 156
Cdd:cd24076   84 apnlG-----WRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 157 GEVS-FLIQDRGIN---GA----ESFAGINlSAVRLVKELTklfqcEPEGPLVFDYLYQ---KEDDQAQTLYRTYCNQVA 225
Cdd:cd24076  159 GEIGhMTVDPDGPPcscGNrgcwETYASER-ALLRAAGRLG-----AGGEPLSLAELVEaarAGDPAALAALEEVGEYLG 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488261292 226 ILCFNIQCLLDLDKIIIGGGISKQKRLIRdiqknyeaifsvsPMIEQTITKMT---------IEAAAFESEANLIGAA 294
Cdd:cd24076  233 IGLANLVNTFNPELVVLGGALAPLGPWLL-------------PPLRAEVARRAlpapardvrIVVSRLGEDAAALGAA 297
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 8-294 4.11e-19

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 85.28  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   8 TLSIDIGGTYIKSALI-MDTQIREKRQIETPKTDKDNFILVLVELIRSYQQIEP-----IEFVGFSVPGAVKEASTVFFG 81
Cdd:cd24077    3 SIGIDLGYNYISLMLTyLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPktpygLVGIGIGIHGIVDENEIIFTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  82 GAVacLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHlkGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVS- 160
Cdd:cd24077   83 YYD--LEDIDLKEKLEEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIGh 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 161 FLIQDRGINGA-------ESFAginlSAVRLVKELTKLFQCEPEGPLVFDYLYQKEDDQAQTLYRTYCNQVAILCFNIQC 233
Cdd:cd24077  159 MIIVPNGKPCPcgnkgclEQYA----SEKALLKELSEKKGLETLTFDDLIQLYNEGDPEALELIDQFIKYLAIGINNIIN 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488261292 234 LLDLDKIIIGGGISKQ-KRLIRDIQKNYEAIFSvspmieqtiTKMTIEAAAFESEANLIGAA 294
Cdd:cd24077  235 TFNPEIIIINSSLINEiPELLEKIKEQLSSSFN---------KYVEILISTLGKNATLLGGA 287
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 9-294 4.33e-19

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 85.24  E-value: 4.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALI-MDTQIREKRQIETP-KTDKDNFILVLVELIRSYQQIEPIEFVGFSVPGAV-KEASTVFFGGAVA 85
Cdd:cd24064    2 IGIDLGGTDTKIGIVdENGDILKKKTIDTKvENGKEDVINRIAETVNELIEEMELLGIGIGSPGSIdRENGIVRFSPNFP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  86 CLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLIQD 165
Cdd:cd24064   82 DWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAELGHVIVE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 166 ----------RG-INGAESFAGINLSAVRLVKELTKLFQCEPE---GPLVFDyLYQKEDDQAQTLYRTYCNQVAILCFNI 231
Cdd:cd24064  162 pngpicgcgnRGcVEAFASATAIIRYARESRKRYPDSLAGESEkinAKHVFD-AARKNDPLATMVFRRVVDALAIAIGGF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488261292 232 QCLLDLDKIIIGGGISKQKRL----IRDIQKNYeaifsVSPMIEQTitkMTIEAAAFESEANLIGAA 294
Cdd:cd24064  241 VHIFNPEIIIIGGGISRAGSFlldpIREKTKKY-----VMLSFQDT---YSIELSNLVEDAGILGAA 299
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 9-244 4.91e-16

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 76.94  E-value: 4.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALI-MDTQIREKRQIETPKTDKDNFILVLV-----ELIRSYQQIEPIEFVGFSVPGAVKEASTVFFGG 82
Cdd:cd24071    4 IGVKIEEGYLVLALTdLKGKILEKTRIPFDHETDPEKVIELIaenikKLIKNKHVEKKLLGIGIAVSGLVDSKKGIVIRS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  83 AVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFL 162
Cdd:cd24071   84 TILGWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGEIGHM 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 163 IQDrgINGAE-------------SFAGINLSAVRLvKELTKLFQCEPEGPLVFDYLYQ--KEDDQ-AQTLYRTYCNQVAI 226
Cdd:cd24071  164 TIQ--PDGRKcycgqkgcleayaSFEALVNEIKEL-TESYPLSLLKELEDFEIEKVREaaEEGDSvATELFKKAGEYLGI 240

                        250
                 ....*....|....*...
gi 488261292 227 LCFNIQCLLDLDKIIIGG 244
Cdd:cd24071  241 GIKNLINIFNPEAIIIGG 258
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 10-294 1.45e-15

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 75.27  E-value: 1.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  10 SIDIGGTYIKSAL-IMDTQIREKRQIETpkTDKDNFILVLVELIRSYQqiEPIEFVGFSVPGAVkeastvffggavaCLN 88
Cdd:cd24067    3 GIEAGGTKFVCAVgTGDGNIIERTEFPT--TTPEETLQAVIDFFREQE--EPIDAIGIASFGPI-------------DLN 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  89 E------------------VNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRK 150
Cdd:cd24067   66 PtsptygyitttpkpgwrnFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVH 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 151 GP-HCQAGEVSFLIQ--DRGINGAESF---------AGINLSAvRLVKELTKLFQCEPEGPLVFDYLyqkeddqaqtlyr 218
Cdd:cd24067  146 GLlHPEMGHIRVPRHpdDDGFPGVCPFhgdcleglaSGPAIAA-RWGIPAEELPDDHPAWDLEAYYL------------- 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488261292 219 tycnqvAILCFNIQCLLDLDKIIIGGGISKQKRLIRDIQKNYEAI---FSVSPMIEQTITKMtIEAAAFESEANLIGAA 294
Cdd:cd24067  212 ------AQACANLTLTLSPERIVLGGGVMQRPGLFPRIREKFRKLlngYLEVPRLLPDIDEY-IVPPALGNDAGILGAL 283
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 12-268 7.60e-14

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 70.40  E-value: 7.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  12 DIGGTYIKSAlIMDTQIR---EKRqIETPKTDKDNFILVLVELIRSYQQiepiEF-----VGFSVPGAVKEASTVFFGGA 83
Cdd:PRK13310   6 DIGGTKIELG-VFNEKLElqwEER-VPTPRDSYDAFLDAVCELVAEADQ----RFgckgsVGIGIPGMPETEDGTLYAAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  84 VACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSFLi 163
Cdd:PRK13310  80 VPAASGKPLRADLSARLGRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRSYITGEFGHM- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 164 qdrgingaesfaGINLSAVRLVKELTKLFQ--CEPEGPLV-------FDYLYQ---------KE--------DDQAQTLY 217
Cdd:PRK13310 159 ------------RLPVDALTLLGWDAPLRRcgCGQKGCIEnylsgrgFEWLYQhyygeplqaPEiialyyqgDEQAVAHV 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488261292 218 RTYCNQVAILCFNIQCLLDLDKIIIGGGISkqkrlirdiqkNYEAIFSVSP 268
Cdd:PRK13310 227 ERYLDLLAICLGNILTIVDPHLVVLGGGLS-----------NFDAIYEQLP 266
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 8-295 1.25e-13

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 69.14  E-value: 1.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   8 TLSIDIGGTYIKSAlIMDTQ----IREKRQIETPKTDKDNFIL-VLVELIRSYQQIEPIEfVGFsvPGAVKEastvffGG 82
Cdd:cd24058    1 ILGIDIGGSGIKGA-IVDTDtgelLSERIRIPTPQPATPEAVAdVVAELVAHFPWFGPVG-VGF--PGVVRR------GV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  83 AVACLN------EVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIEnGAGII--LGTGVGVGLLLDGQVrkGPHC 154
Cdd:cd24058   71 VRTAANldkswiGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEK-GVVLVltLGTGIGSALFVDGHL--VPNT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 155 QAGEVSFliqdRGiNGAESFAginLSAVRLVKELTklfqcepegplvfdylYQKEDDQAQTLYRTYcnqVAILCFniqcl 234
Cdd:cd24058  148 ELGHLEI----RG-KDAEERA---SLGVRAREDLG----------------WKRWAKRVNKYLQYL---ERLFNP----- 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488261292 235 ldlDKIIIGGGISKQkrlirdiqknyeaIFSVSPMIEqtiTKMTIEAAAFESEANLIGAAK 295
Cdd:cd24058  196 ---DLFIIGGGNSKK-------------ADKFLPLLD---VKTPVVPAVLRNDAGIVGAAL 237
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 64-159 3.28e-13

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 68.73  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  64 VGFSVPGAVKEAS-----TVFFGgavacLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGV 138
Cdd:cd24073   65 IGVGLPGLVDAETgicrwSPLLG-----WRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGI 139

                         90       100
                 ....*....|....*....|.
gi 488261292 139 GVGLLLDGQVRKGPHCQAGEV 159
Cdd:cd24073  140 GCGLVVDGRLYRGAHGGAGEI 160
PRK09698 PRK09698
D-allose kinase; Provisional
 4-259 1.13e-11

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 64.23  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   4 KSMWtLSIDIGGTYIKSALIMDT-QIREKRQIETPKTDKDNFILVLVELIRSY--QQIEPIEFVGFSVPGAV-KEASTVF 79
Cdd:PRK09698   3 KNVV-LGIDMGGTHIRFCLVDAEgEILHCEKKRTAEVIAPDLVSGLGEMIDEYlrRFNARCHGIVMGFPALVsKDRRTVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  80 FGGAVAC--LNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGiENGAGIILGTGVGVGLLLDGQVRKGPHCQAG 157
Cdd:PRK09698  82 STPNLPLtaLDLYDLADKLENTLNCPVFFSRDVNLQLLWDVKENNLTQ-QLVLGAYLGTGMGFAVWMNGAPWTGAHGVAG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 158 EVSFLIQ-DRGIN---GAESFAGINLSAVRLVKELTK---------LFQCEPEGPLVFDYLyqkeddqaQTLYRTYCNQV 224
Cdd:PRK09698 161 ELGHIPLgDMTQHcgcGNPGCLETNCSGMALRRWYEQqprdyplsdLFVHAGDHPFIQSLL--------ENLARAIATSI 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 488261292 225 AIlcfniqclLDLDKIIIGGGISKQK-----RLIRDIQKN 259
Cdd:PRK09698 233 NL--------FDPDAIILGGGVMDMPafpreTLIAMIQKY 264
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 9-294 6.53e-10

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 59.25  E-value: 6.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSAL--IMDTQIREKRQiETPKTDKDNFILVLVELI-----RSYQQIEPIEFVGFSVPGAVKEASTVFFG 81
Cdd:cd24074    5 LSIRIGRGYITLALrdLNGRLLAEERY-PLPAKDNDPFLDRLLESIseffsRHQKKLERLTAIAITLPGIIDPESGIVHR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  82 GAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEVSF 161
Cdd:cd24074   84 LPFYDIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGH 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 162 L-IQDRGIN---G----AESFAGINlSAVRLVKELTKLFQ--CEPEGPLVFDYLYQ---KEDDQAQTLYRTYCNQVAILC 228
Cdd:cd24074  164 TqIDPYGKRcycGnhgcLETVASIP-AILEQANQLLEQSPdsMLHGQPISIESLCQaalAGDPLAQDIIIQVGRHLGRIL 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488261292 229 FNIQCLLDLDKIIIGGGISKQKRLIrdiqknyeaifsvSPMIEQTI---------TKMTIEAAAFESEANLIGAA 294
Cdd:cd24074  243 AILVNLFNPEKILIGSPLNNAAEIL-------------FPALSQSIrqqslpaysQHLQIESTKFYNDGTMPGAA 304
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 59-281 1.33e-08

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 55.11  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  59 EPIEFVGFSVPGAVKEASTVFFGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGV 138
Cdd:cd24072   58 DRVKGIALAIQGLVDSHKGVSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 139 GVGLLLDGQVRKGPHCQAGEVSFLIQDrgINGA----------ESFAGIN--LSAVRLVKELTKLFQCEPEGPL-VFDYL 205
Cdd:cd24072  138 GSAIVIDNKLYIGASSGSGEIGHTKVN--PDGArcdcgrrgclETVASNSalKRNARVTLKLGPVSADPEKLTMeQLIEA 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488261292 206 YQKEDDQAQTLYRTYCNQVAILCFNIQCLLDLDKIII-GGGISKQKRLIRDIQKnyeAIFSVSPMIEQTITKMTIEA 281
Cdd:cd24072  216 LEEGEPIATQIFDRAANAIGRSLANILNLLNPEQVLLyGRGCRAGDLLLPAIRR---AIAENPFSQHATQIGFGQLS 289
ASKHA_NBD_GspK-like cd24082
nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar ...
 81-259 5.15e-08

nucleotide-binding domain (NBD) of Vibrio cholerae glucosamine kinase GspK and similar proteins; The family includes a group of uncharacterized proteins similar to Vibrio cholerae glucosamine kinase GspK (EC 2.7.1.8), also called GlcN kinase. It acts as ATP-dependent kinase, which is specific for glucosamine. GspK does not show kinase activity with any other sugar.


Pssm-ID: 466932 [Multi-domain]  Cd Length: 279  Bit Score: 52.92  E-value: 5.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  81 GGAVACLNEVNLKQEIEKHLPV--RVFVENDAKAAVLGeASFGhlkgiENGAGIILGTGVGVGLLLDGQVRkgphcQAGE 158
Cdd:cd24082   69 GLGLAGANVPEARAAFLAALPPfaSLVVVSDAHIACLG-AHGG-----EDGAIIILGTGSVGAALDGGEVR-----QVGG 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292 159 VSFLIQDRGingaeSFAGINLSAVR--------------LVKELTKLFQCEPEG-----------------PLVFDYlYQ 207
Cdd:cd24082  138 WGFPLGDEG-----SGAWLGLRALRhtllaldglapsspLTRAVLARFGGDPAEivawantatpadfaalaPLVFEA-AE 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488261292 208 KEDDQAQTLYRTYCNQVAILcfnIQCLLDL--DKIIIGGGISK--QKRLIRDIQKN 259
Cdd:cd24082  212 QGDPVALAILQEAAAYIERL---LRALGAQgaLPLCLLGGLAErlAPYLPEDLQAR 264
PRK09557 PRK09557
fructokinase; Reviewed
 11-158 2.13e-07

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 51.18  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  11 IDIGGTYIKS-ALIMDTQIREKRQIETPKTDKDNFILVLVELIR-SYQQIEPIEFVGFSVPGAVKEastvfFGGAVACLN 88
Cdd:PRK09557   5 IDLGGTKIEViALDDAGEELFRKRLPTPRDDYQQTIEAIATLVDmAEQATGQRGTVGVGIPGSISP-----YTGLVKNAN 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488261292  89 EVNLK-QEIEKHLPVR----VFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGE 158
Cdd:PRK09557  80 STWLNgQPLDKDLSARlnreVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGE 154
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 12-158 4.32e-07

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 50.03  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  12 DIGGTYIKSAlIMDTQIRE--KRQIETPKTDKDNFILVLVELIRSYQQIEPIE-FVGFSVPGAVKEASTVFFGGAVACLN 88
Cdd:PRK13311   6 DMGGTKIELG-VFDENLQRiwHKRVPTPREDYPQLLQILRDLTEEADTYCGVQgSVGIGIPGLPNADDGTVFTANVPSAM 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  89 EVNLKQEIEKHLPVRVFVENDAKAAVLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGE 158
Cdd:PRK13311  85 GQPLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGE 154
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 9-158 9.46e-07

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 49.53  E-value: 9.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTYIKSALIMDT--QIREKRQIETPKTDKDNFILVLVELIRSYqQIEPIEFVGFSVPGAVKEASTVFFggavac 86
Cdd:cd24008    2 LVGDIGGTNARLALADAGdgSGDLLFVRKYPSADFASLEDALAAFLAEL-GAPRPKAACIAVAGPVDGGRVRLT------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  87 lnevNLK-----QEIEKHLPV-RVFVEND--AKA---AVLGEASFGHLKG----IENGAGIIL--GTGVGVGLLLDGQvR 149
Cdd:cd24008   75 ----NLDwsidaAELRKALGIgRVRLLNDfeAAAyglPALGPEDLLVLYGgggpLPGGPRAVLgpGTGLGVALLVPDG-D 149


                 ....*....
gi 488261292 150 KGPHCQAGE 158
Cdd:cd24008  150 GGYVVLPSE 158
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 9-150 1.88e-06

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 48.34  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292   9 LSIDIGGTyiKS-ALIMDTQIREKRQIET---------PKTDKDNFILVLVELIRSYQQIEPIEFVGFSVPGAVKEAstv 78
Cdd:COG2971    4 LGVDGGGT--KTrAVLVDADGEVLGRGRAgganpqsvgLEEALASLREALEEALAAAGDPADIEAVGFGLAGAGTPE--- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488261292  79 ffggavaclNEVNLKQEIEKHLPV-RVFVENDAKAAVLGeaSFGHlkgiENGAGIILGTG-VGVGLLLDGQVRK 150
Cdd:COG2971   79 ---------DAEALEAALRELFPFaRVVVVNDALAALAG--ALGG----EDGIVVIAGTGsIAAGRDGDGRTAR 137
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 35-159 3.33e-06

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 47.75  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488261292  35 ETPKTDKDNFILVLVELIRSYQQI-EPIEFVGFSVPGAVKEASTVFFGGAVACLNEVNLKQEIEKHLPVRVFVENDAKAA 113
Cdd:cd24075   35 LNQEALLSQLIEEIAQFLKSHRRKtQRLIAISITLPGLINPKTGVVHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSL 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 488261292 114 VLGEASFGHLKGIENGAGIILGTGVGVGLLLDGQVRKGPHCQAGEV 159
Cdd:cd24075  115 ALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH