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Conserved domains on  [gi|488224617|ref|WP_002295825|]
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MULTISPECIES: endonuclease III [Enterococcus]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-205 1.51e-116

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 330.13  E-value: 1.51e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  11 LETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYRNKAKNI 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  91 KACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDaTVMEVEETLMRKVP 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGK-DPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488224617 171 QELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSIC 205
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-205 1.51e-116

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 330.13  E-value: 1.51e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  11 LETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYRNKAKNI 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  91 KACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDaTVMEVEETLMRKVP 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGK-DPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488224617 171 QELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSIC 205
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-196 5.37e-102

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 293.52  E-value: 5.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617    4 KQKTMEALETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLY 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   84 RNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKlDATVMEVEE 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSK-GKDPIKVEE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 488224617  164 TLMRKVPQELWVKTHHTLIFFGRYHCTARNPKC 196
Cdd:TIGR01083 160 DLMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 2-206 7.63e-66

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 202.55  E-value: 7.63e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   2 LSKQKTMEALETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIG 81
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  82 LYRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKlDATVMEV 161
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAP-GKNVEQV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488224617 162 EETLMRKVPQELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSICQ 206
Cdd:PRK10702 160 EEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCE 204
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-187 1.17e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 179.38  E-value: 1.17e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617    39 LSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488224617   119 GRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQELWVKTHHTLIFFGRY 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-185 6.09e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 177.82  E-value: 6.09e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  31 FELLIAVILSAQATDVSVNKATPDLFASF-PTPDALAEASIDEIILKIKTIGlYRNKAKNIKACAQQLIERFDGQV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488224617 107 TSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQELWVKTHHTLIFFG 185
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-171 1.79e-44

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 145.50  E-value: 1.79e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   35 IAVILSAQATDVSVNKATPDLFA-SFPTPDALAEASIDEIILKIKTIGLYRNKAKNIKACAQQLIERFDGQVPTSREELM 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEkFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488224617  114 S-LPGVGRKTANVVLGDAFG--IPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQ 171
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-205 1.51e-116

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 330.13  E-value: 1.51e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  11 LETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYRNKAKNI 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  91 KACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDaTVMEVEETLMRKVP 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGK-DPEEVEKDLMKLIP 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488224617 171 QELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSIC 205
Cdd:COG0177  160 KEYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 4-196 5.37e-102

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 293.52  E-value: 5.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617    4 KQKTMEALETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLY 83
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   84 RNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKlDATVMEVEE 163
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSK-GKDPIKVEE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 488224617  164 TLMRKVPQELWVKTHHTLIFFGRYHCTARNPKC 196
Cdd:TIGR01083 160 DLMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 2-206 7.63e-66

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 202.55  E-value: 7.63e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   2 LSKQKTMEALETMYGMFPEAHGELKHNNPFELLIAVILSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIG 81
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  82 LYRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKlDATVMEV 161
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAP-GKNVEQV 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488224617 162 EETLMRKVPQELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSICQ 206
Cdd:PRK10702 160 EEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCE 204
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-187 1.17e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 179.38  E-value: 1.17e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617    39 LSAQATDVSVNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488224617   119 GRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQELWVKTHHTLIFFGRY 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-185 6.09e-57

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 177.82  E-value: 6.09e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  31 FELLIAVILSAQATDVSVNKATPDLFASF-PTPDALAEASIDEIILKIKTIGlYRNKAKNIKACAQQLIERFDGQV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488224617 107 TSREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQELWVKTHHTLIFFG 185
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-171 1.79e-44

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 145.50  E-value: 1.79e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   35 IAVILSAQATDVSVNKATPDLFA-SFPTPDALAEASIDEIILKIKTIGLYRNKAKNIKACAQQLIERFDGQVPTSREELM 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEkFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488224617  114 S-LPGVGRKTANVVLGDAFG--IPAIAVDTHVERVSKRLRICKLDATVMEVEETLMRKVPQ 171
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPTPKEVERELEELWPP 141
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 57-206 4.52e-28

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 108.69  E-value: 4.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  57 ASFPTPDALAEASIDEIiLKIKTiGL-YRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPA 135
Cdd:COG1194   56 ERFPTVEALAAAPEDEV-LKLWE-GLgYYSRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617 136 IAVDTHVERVSKRLrickldatvMEVEETLMR-KVPQELWVKTHHTL------IF------FGRYHCTARNPKCEVCPLL 202
Cdd:COG1194  134 PIVDGNVKRVLSRL---------FAIEGPIGSpAAKKELWALAEELLpperpgDFnqalmdLGATVCTPKKPKCLLCPLQ 204


                 ....
gi 488224617 203 SICQ 206
Cdd:COG1194  205 DDCA 208
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 1-210 1.64e-26

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 101.46  E-value: 1.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   1 MLSKQKTMEALETMYGMFPEAH---GElkhnNPFELLIAVILsAQATD-VSVNKA-----TPDLFasfpTPDALAEASID 71
Cdd:COG2231    1 MNTKEDLLEIYERLLEHYGPQHwwpAE----TPFEVIVGAIL-TQNTSwKNVEKAianlkEAGLL----DPEALAALDPE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  72 EIILKIKTIGLYRNKAKNIKACAQQLIERFDG------QVPTS--REELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVE 143
Cdd:COG2231   72 ELAELIRPSGFYNQKAKRLKNLARWLVERYGGgleklkALPTEelREELLSLKGIGPETADSILLYAFNRPVFVVDAYTR 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488224617 144 RVSKRLRICKLDATVMEVEETLMRKVPQELWV-KTHHTLIF-FGRYHCTARnPKCEVCPLLSICQDGKN 210
Cdd:COG2231  152 RIFSRLGLIEEDASYDELQRLFEENLPPDVALyNEFHALIVeHGKEYCKKK-PKCEECPLRDLCPYGGQ 219
mutY TIGR01084
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the ...
 59-206 6.26e-26

A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130156  Cd Length: 275  Bit Score: 101.33  E-value: 6.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   59 FPTPDALAEASIDEIiLKIKTiGL-YRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPAIA 137
Cdd:TIGR01084  55 FPTVQALANAPQDEV-LKLWE-GLgYYARARNLHKAAQEVVEEFGGEFPQDFEDLAALPGVGRYTAGAILSFALNKPYPI 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488224617  138 VDTHVERVSKRLRICKLDATVMEVE---ETLMRKV-PQELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSICQ 206
Cdd:TIGR01084 133 LDGNVKRVLSRLFAVEGWPGKKKVEnrlWTLAESLlPKADPEAFNQALMDLGAMICTRKKPKCDLCPLQDFCL 205
PRK10880 PRK10880
adenine DNA glycosylase;
57-205 2.22e-19

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 85.15  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  57 ASFPTPDALAEASIDEIiLKIKTiGL-YRNKAKNIKACAQQLIERFDGQVPTSREELMSLPGVGRKTANVVLGDAFGIPA 135
Cdd:PRK10880  57 ARFPTVTDLANAPLDEV-LHLWT-GLgYYARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHF 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488224617 136 IAVDTHVERVSKRLRICKLDATVMEVEETLM----RKVPQELWVKTHHTLIFFGRYHCTARNPKCEVCPLLSIC 205
Cdd:PRK10880 135 PILDGNVKRVLARCYAVSGWPGKKEVENRLWqlseQVTPAVGVERFNQAMMDLGAMVCTRSKPKCELCPLQNGC 208
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 20-149 1.41e-16

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 76.08  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  20 EAHGEL---KHNNPFELLIAVILSAQatdVSVNKAT-----------------PDLFASFPTPDALAEASIDEIilkiKT 79
Cdd:COG0122   71 ERYPGLrlpRRPDPFEALVRAILGQQ---VSVAAARtiwrrlvalfgepiegpGGGLYAFPTPEALAAASEEEL----RA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  80 IGLYRNKAKNIKACAQQLIE---RFDGQVPTS----REELMSLPGVGRKTANVVL------GDAFgiPaiAVDTHVERVS 146
Cdd:COG0122  144 CGLSRRKARYLRALARAVADgelDLEALAGLDdeeaIARLTALPGIGPWTAEMVLlfalgrPDAF--P--AGDLGLRRAL 219


                 ...
gi 488224617 147 KRL 149
Cdd:COG0122  220 GRL 222
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 41-222 3.74e-16

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 75.44  E-value: 3.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  41 AQATDVS--VNKATPDLFASFPTPDALAEASIDEIILKIKTIGLYrNKAKNIKACAQQLIERFDGQVPTSREELMSLPGV 118
Cdd:PRK13910   2 SQQTQINtvVERFYSPFLEAFPTLKDLANAPLEEVLLLWRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617 119 GRKTANVVLGDAFGIPAIAVDTHVERVskRLRICKLDATVMevEETLMRKVPQELWVKT----HHTLIFFGRYHCTARnP 194
Cdd:PRK13910  81 GAYTANAILCFGFREKSACVDANIKRV--LLRLFGLDPNIH--AKDLQIKANDFLNLNEsfnhNQALIDLGALICSPK-P 155

                        170       180
                 ....*....|....*....|....*...
gi 488224617 195 KCEVCPLLSICQdGKNrmRLKEKTLKKK 222
Cdd:PRK13910 156 KCAICPLNPYCL-GKN--NPEKHTLKKK 180
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 29-148 1.90e-10

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 59.54  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617   29 NPFELLIAVILSAQATDVSVNKATPDL---------------FASFPTPDALAEASIDEiilKIKTIGL-YRnkAKNIKA 92
Cdd:TIGR00588 118 DPFECLISFICSSNNNIARITRMVERLcqafgprlitldgvtYHGFPSLHALTGPEAEA---HLRKLGLgYR--ARYIRE 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488224617   93 CAQQLIERFDG----------QVPTSREELMSLPGVGRKTANVVLGDAFGIP-AIAVDTHVERVSKR 148
Cdd:TIGR00588 193 TARALLEEQGGrawlqqirgaSYEDAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 100-127 6.24e-09

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 50.11  E-value: 6.24e-09
                          10        20
                  ....*....|....*....|....*...
gi 488224617  100 RFDGQVPTSREELMSLPGVGRKTANVVL 127
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAIL 28
EndIII_4Fe-2S pfam10576
Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99. ...
 189-205 1.39e-05

Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease.


Pssm-ID: 463153 [Multi-domain]  Cd Length: 17  Bit Score: 40.83  E-value: 1.39e-05
                          10
                  ....*....|....*..
gi 488224617  189 CTARNPKCEVCPLLSIC 205
Cdd:pfam10576   1 CTARKPKCEECPLADLC 17
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 188-205 2.41e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 37.14  E-value: 2.41e-04
                           10
                   ....*....|....*...
gi 488224617   188 HCTARNPKCEVCPLLSIC 205
Cdd:smart00525   1 ICTARKPRCDECPLKDLC 18
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 31-149 3.48e-04

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 40.22  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488224617  31 FELLIAVILSAQATDVSVNKATPDL-----FASFPTPDALAEASIDEIILK--IKTIGLYRNKAKNIKACAQQLIERFdG 103
Cdd:PRK13913  31 FEALLGAVLTQNTKFEAVEKSLENLknafiLENDDEINLKKIAYIEFSKLAecVRPSGFYNQKAKRLIDLSENILKDF-G 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488224617 104 QVPT-----SREELMSLPGVGRKTANVVLGDAFGIPAIAVDTHVERVSKRL 149
Cdd:PRK13913 110 SFENfkqevTREWLLDQKGIGKESADAILCYVCAKEVMVVDKYSYLFLKKL 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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