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Conserved domains on  [gi|488175989|ref|WP_002247197|]
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decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase [Neisseria meningitidis]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 913.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILG 240
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 241 YKD-EGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFAR-TVTPVEGGKQEWV 318
Cdd:COG0362  240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGpEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 319 EALRQTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILE 398
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 399 NCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 913.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILG 240
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 241 YKD-EGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFAR-TVTPVEGGKQEWV 318
Cdd:COG0362  240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGpEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 319 EALRQTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILE 398
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 399 NCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-472 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 895.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  13 MGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDFIEQLLPLLE 92
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  93 EGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDW 172
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 173 VGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKD-EGGEPLVE 251
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 252 KILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQTLLASKII 331
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 332 SYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLPAWRKVVAKA 411
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488175989 412 VECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTGKG 472
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEG--FFHTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 858.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989    4 DIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDF 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   84 IEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIAAKT 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  164 pQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  244 EGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGG-KQEWVEALR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVdKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  323 QTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLP 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488175989  403 AWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 179-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 551.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  179 GHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKDEG-GEPLVEKILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  258 GQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQ-TGKLFARTVTPVEGGKQEWVEALRQTLLASKIISYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAaSKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  337 FMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLPAWRKVVAKAVECGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488175989  417 PMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKprGEFFHTNW 468
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDK--EGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 1-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 913.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:COG0362    1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:COG0362   81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILG 240
Cdd:COG0362  161 AKV-DGEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 241 YKD-EGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFAR-TVTPVEGGKQEWV 318
Cdd:COG0362  240 KKDpETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGpEAAPFEGDKEAFI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 319 EALRQTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILE 398
Cdd:COG0362  320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 399 NCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNW 468
Cdd:COG0362  400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEG--FFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
13-472 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 895.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  13 MGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDFIEQLLPLLE 92
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  93 EGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIAAKTPQGEPCCDW 172
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 173 VGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKD-EGGEPLVE 251
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDeETGKPLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 252 KILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGGKQEWVEALRQTLLASKII 331
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKFEGDKAEFIEDVRQALYASKIV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 332 SYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLPAWRKVVAKA 411
Cdd:PRK09287 321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488175989 412 VECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRgeFFHTNWTGKG 472
Cdd:PRK09287 401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEG--FFHTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 4-470 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 858.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989    4 DIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDF 83
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   84 IEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIAAKT 163
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  164 pQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKD 243
Cdd:TIGR00873 161 -DGEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  244 EGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGG-KQEWVEALR 322
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVdKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  323 QTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLP 402
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488175989  403 AWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 470
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTG 467
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 2-469 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 661.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   2 KGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAK-GTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:PTZ00142   1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEgNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:PTZ00142  81 DETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTpQGEPCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILG 240
Cdd:PTZ00142 161 AKV-GDSPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 241 YK-DEGGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFA---RTVTPVEGGKQE 316
Cdd:PTZ00142 240 KKdDLGEEHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAgpnPANKTETEDKKY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 317 WVEALRQTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNI 396
Cdd:PTZ00142 320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488175989 397 LENCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPRGefFHTNWT 469
Cdd:PTZ00142 400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGA--FHTNWE 470
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 1-480 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 570.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAK--GTGIIGAYSLQDLVDKLAKPRKIMMMVRAGS 78
Cdd:PLN02350   5 ALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVERAKKegNLPLYGFKDPEDFVLSIQKPRSVIILVKAGA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  79 VVDDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQA 158
Cdd:PLN02350  85 PVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEK 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 159 IAAKTPQGePCCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAI 238
Cdd:PLN02350 165 VAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 239 LGYKDEGGE-PLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQTGKLFARTVTPVEGG---- 313
Cdd:PLN02350 244 FSVKDDKGDgYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAGLEDILSadsg 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 314 --KQEWVEALRQTLLASKIISYAQGFMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDP 391
Cdd:PLN02350 324 vdKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDP 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 392 YFKNILENCLPAWRKVVAKAVECGIPMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKPrgEFFHTNWT-- 469
Cdd:PLN02350 404 EFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRP--GSFHTEWTkl 481

                        490
                 ....*....|..
gi 488175989 470 -GKGGDTASTTY 480
Cdd:PLN02350 482 aRKSKIITGRTA 493
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 179-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 551.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  179 GHFVKMVHNGIEYGDMQLICEAYQFMKDGLGLSYDEMHRVFAEWNKTELDSYLIEITAAILGYKDEG-GEPLVEKILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEdGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  258 GQKGTGKWTGINALDLGIPLTLISEAVFARCVSSFKEQRVQ-TGKLFARTVTPVEGGKQEWVEALRQTLLASKIISYAQG 336
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAaSKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  337 FMLIREAGESYGWDLDYGNTALLWREGCIIRSAFLSNIRDAYENNPDLVFLGTDPYFKNILENCLPAWRKVVAKAVECGI 416
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488175989  417 PMPCMASAITFLDGYTTERLPANLLQAQRDYFGAHTYERTDKprGEFFHTNW 468
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDK--EGFFHTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
1-287 4.19e-91

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 279.28  E-value: 4.19e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKgdIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEflngaAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:COG1023    1 MQ--IGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAVAA-----LAAEGATGADSLEELVAKLPAPRVVWLMVPAGEIT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:COG1023   74 DQVIEELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTPQGepcCDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGlGLSYDeMHRVFAEWNK-TELDSYLIEITAAIL 239
Cdd:COG1023  154 PGAENG---YLHCGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEAS-EFDLD-LAEVAEVWRRgSVIRSWLLDLTADAL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488175989 240 gYKDeggePLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFAR 287
Cdd:COG1023  229 -AED----PKLEGISGYVEDSGEGRWTVEEAIELGVPAPVITAALFAR 271
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
1-287 2.46e-89

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 274.70  E-value: 2.46e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKgdIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDeflngAAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGSVV 80
Cdd:PRK09599   1 MQ--LGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVE-----ALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEIT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFIEQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIA 160
Cdd:PRK09599  74 DATIDELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989 161 AKTPQGepccdWV--GRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDGlGLSYDeMHRVFAEWNK-TELDSYLIEITAA 237
Cdd:PRK09599 154 PRAEDG-----YLhaGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLEAS-RFDLD-LAAVAEVWRRgSVIRSWLLDLTAD 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 488175989 238 ILGyKDeggePLVEKILDTAGQKGTGKWTGINALDLGIPLTLISEAVFAR 287
Cdd:PRK09599 227 ALA-ED----PKLDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAALFMR 271
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 4-174 1.64e-63

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 203.09  E-value: 1.64e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989    4 DIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLngaakGTGIIGAYSLQDLVDKLakpRKIMMMVRAGSVVDDF 83
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELV-----AAGAIAAASPAEFVAGL---DVVITMVPAGAAVDAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   84 IEQ--LLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGP-SIMPGGDKRAWEAVKPIFQAIA 160
Cdd:pfam03446  73 IFGegLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG 152

                         170
                  ....*....|....
gi 488175989  161 AktpqgepCCDWVG 174
Cdd:pfam03446 153 A-------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 5-290 2.42e-54

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 184.28  E-value: 2.42e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989    5 IGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEflngaAKGTGIIGAYSLQDLVDKLAKPRKIMMMVRAGsVVDDFI 84
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAVKA-----MKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   85 EQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGPSIMPGGDKRAWEAVKPIFQAIAAKTp 164
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEE- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  165 QGEPCCdwvGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDG-LGLSYDEMHRVfaeWNK-TELDSYLIEITAaiLGYK 242
Cdd:TIGR00872 156 QGYLYC---GPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARV---WRRgSVIRSWLLDLTA--IAFR 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 488175989  243 DEGGEPLVEKILDTAGQkgtGKWTGINALDLGIPLTLISEAVFARCVS 290
Cdd:TIGR00872 228 ESPDLAEFSGRVSDSGE---GRWTVIAAIDLGVPAPVIATSLQSRFAS 272
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 5-222 2.46e-26

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 107.89  E-value: 2.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   5 IGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLngaakGTGIIGAYSLQDLVdklakpRK---IMMMVRAGSVVD 81
Cdd:COG2084    4 VGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALV-----AAGARVAASPAEAA------AAadvVITMLPDDAAVE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  82 DFI---EQLLPLLEEGDIIIDGGNANySDTTRRTH-YLAGKGILFVGAGVSGGEEGARRGP-SIMPGGDKRAWEAVKPIF 156
Cdd:COG2084   73 EVLlgeDGLLAALRPGAVVVDMSTIS-PETARELAaAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVL 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488175989 157 QAIAAKTpqgepccDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQFMKDgLGLSYDEMHRVFAEW 222
Cdd:COG2084  152 EAMGKRI-------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 1-184 1.61e-14

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 73.93  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   1 MKGDIGVIGLAVMGQNLILNMNDCGFKVVAYNRTIGKVDEFLNGAAKgtgiiGAYSLQDLVdklAKPRKIMMMVRAGSVV 80
Cdd:PRK11559   1 MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAE-----TASTAKAVA---EQCDVIITMLPNSPHV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  81 DDFI---EQLLPLLEEGDIIIDggNANYSDTTRRTHY--LAGKGILFVGAGVSGGEEGARRGP-SIMPGGDKRAWEAVKP 154
Cdd:PRK11559  73 KEVAlgeNGIIEGAKPGTVVID--MSSIAPLASREIAaaLKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYD 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 488175989 155 IFQAIAAKTPQgepccdwVGRDGAGHFVKM 184
Cdd:PRK11559 151 LMKAMAGSVVH-------TGDIGAGNVTKL 173
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
5-203 3.28e-10

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 61.19  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989   5 IGVIGLAVMGQNLILNMNDCGFKVvaYNRTIGKV-DEFLNgaakgtgiIGAYSLQDLVDKLAKPRKIMMMVRAGSVVDDF 83
Cdd:PRK15059   3 LGFIGLGIMGTPMAINLARAGHQL--HVTTIGPVaDELLS--------LGAVSVETARQVTEASDIIFIMVPDTPQVEEV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488175989  84 I---EQLLPLLEEGDIIIDGGNANYSDTTRRTHYLAGKGILFVGAGVSGGEEGARRGP-SIMPGGDKRAWEAVKPIFQAI 159
Cdd:PRK15059  73 LfgeNGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELL 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 488175989 160 AAKTpqgepccDWVGRDGAGHFVKMVHNGIEYGDMQLICEAYQF 203
Cdd:PRK15059 153 GKNI-------TLVGGNGDGQTCKVANQIIVALNIEAVSEALLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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