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Conserved domains on  [gi|488169315|ref|WP_002240523|]
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class I SAM-dependent methyltransferase [Neisseria meningitidis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1002172)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens tRNA wybutosine-synthesizing protein 4

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmC super family cl34491
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 154-323 1.72e-24

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


The actual alignment was detected with superfamily member COG2813:

Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 98.72  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 154 VAVPQLGGSIHVPFGVFSPlrgEYLD-----LLAHAPSTGFQTAFDIGTGSGVLAAILAKQG-IPSVIGTDTNPKAVACA 227
Cdd:COG2813   13 VRLAGRDLTFVTLPGVFSR---DRLDigtrlLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNARAVELA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 228 RANIARLGFEkQVEIRETDLF---PEGFADLIVCNPPWlpakptsaveSALYDPESAMLAAFLRDAPKHLNPDGEIRLII 304
Cdd:COG2813   90 RANAAANGLE-NVEVLWSDGLsgvPDGSFDLILSNPPF----------HAGRAVDKEVAHALIADAARHLRPGGELWLVA 158

                        170
                 ....*....|....*....
gi 488169315 305 sdlAEHLGLRPAdfLEKAF 323
Cdd:COG2813  159 ---NRHLPYERK--LEELF 172
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 154-323 1.72e-24

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 98.72  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 154 VAVPQLGGSIHVPFGVFSPlrgEYLD-----LLAHAPSTGFQTAFDIGTGSGVLAAILAKQG-IPSVIGTDTNPKAVACA 227
Cdd:COG2813   13 VRLAGRDLTFVTLPGVFSR---DRLDigtrlLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNARAVELA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 228 RANIARLGFEkQVEIRETDLF---PEGFADLIVCNPPWlpakptsaveSALYDPESAMLAAFLRDAPKHLNPDGEIRLII 304
Cdd:COG2813   90 RANAAANGLE-NVEVLWSDGLsgvPDGSFDLILSNPPF----------HAGRAVDKEVAHALIADAARHLRPGGELWLVA 158

                        170
                 ....*....|....*....
gi 488169315 305 sdlAEHLGLRPAdfLEKAF 323
Cdd:COG2813  159 ---NRHLPYERK--LEELF 172
PRK14968 PRK14968
putative methyltransferase; Provisional
 190-307 2.62e-23

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 95.35  E-value: 2.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 190 QTAFDIGTGSGVLAAILAKQGIpSVIGTDTNPKAVACARANIARLGF-EKQVEIRETDLFpEGFA----DLIVCNPPWLP 264
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKNGK-KVVGVDINPYAVECAKCNAKLNNIrNNGVEVIRSDLF-EPFRgdkfDVILFNPPYLP 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488169315 265 AKPTSAVES----ALYDPESAM--LAAFLRDAPKHLNPDGEIRLIISDL 307
Cdd:PRK14968 103 TEEEEEWDDwlnyALSGGKDGRevIDRFLDEVGRYLKPGGRILLLQSSL 151
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 168-323 6.55e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 83.02  E-value: 6.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  168 GVFSPLRgeyLD-----LLAHAPSTGFQTAFDIGTGSGVLAAILAKQGiP--SVIGTDTNPKAVACARANIARLGFEKqV 240
Cdd:pfam05175   9 GVFSHGR---LDigsrlLLEHLPKDLSGKVLDLGCGAGVLGAALAKES-PdaELTMVDINARALESARENLAANGLEN-G 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  241 EIRETDLF---PEGFADLIVCNPPWLPAKPT--SAVEsalydpesamlaAFLRDAPKHLNPDGEIRLIISdlaEHLGLRP 315
Cdd:pfam05175  84 EVVASDVYsgvEDGKFDLIISNPPFHAGLATtyNVAQ------------RFIADAKRHLRPGGELWIVAN---RFLGYPP 148


                  ....*...
gi 488169315  316 AdfLEKAF 323
Cdd:pfam05175 149 L--LEELF 154
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 194-298 3.49e-15

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 75.08  E-value: 3.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAAILAkQGIP--SVIGTDTNPKAVACARANIARLGFEKQVEIRETDLF---PEGFADLIVCNPPWLPAK-P 267
Cdd:TIGR00536 120 DLGTGSGCIALALA-YEFPnaEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFeplAGQKIDIIVSNPPYIDEEdL 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 488169315  268 TSAVESALYDPESAMLAA---------FLRDAPKHLNPDG 298
Cdd:TIGR00536 199 ADLPNVVRFEPLLALVGGddglnilrqIIELAPDYLKPNG 238
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 191-304 2.28e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.36  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 191 TAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEK----QVEIRETDLFPEGFADLIVCNPPwlpak 266
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNvevlKGDAEELPPEADESFDVIISDPP----- 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488169315 267 ptsavesalYDPESAMLAAFLRDAPKHLNPDGEIRLII 304
Cdd:cd02440   76 ---------LHHLVEDLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 154-323 1.72e-24

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 98.72  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 154 VAVPQLGGSIHVPFGVFSPlrgEYLD-----LLAHAPSTGFQTAFDIGTGSGVLAAILAKQG-IPSVIGTDTNPKAVACA 227
Cdd:COG2813   13 VRLAGRDLTFVTLPGVFSR---DRLDigtrlLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNARAVELA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 228 RANIARLGFEkQVEIRETDLF---PEGFADLIVCNPPWlpakptsaveSALYDPESAMLAAFLRDAPKHLNPDGEIRLII 304
Cdd:COG2813   90 RANAAANGLE-NVEVLWSDGLsgvPDGSFDLILSNPPF----------HAGRAVDKEVAHALIADAARHLRPGGELWLVA 158

                        170
                 ....*....|....*....
gi 488169315 305 sdlAEHLGLRPAdfLEKAF 323
Cdd:COG2813  159 ---NRHLPYERK--LEELF 172
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 181-329 4.24e-24

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 100.22  E-value: 4.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 181 LAHAPSTGFQTAFDIGTGSGVLAAILAKQgIP--SVIGTDTNPKAVACARANIARLGFEKQVEIRETDLF----PEGFAD 254
Cdd:COG2890  105 LALLPAGAPPRVLDLGTGSGAIALALAKE-RPdaRVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFeplpGDGRFD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 255 LIVCNPPWLPA--KPTSAVESALYDPESA---------MLAAFLRDAPKHLNPDGeiRLIIsdlaEHlGLRPADFLEKAF 323
Cdd:COG2890  184 LIVSNPPYIPEdeIALLPPEVRDHEPRLAldggedgldFYRRIIAQAPRLLKPGG--WLLL----EI-GEDQGEAVRALL 256


                 ....*.
gi 488169315 324 IRAGLR 329
Cdd:COG2890  257 EAAGFA 262
PRK14968 PRK14968
putative methyltransferase; Provisional
 190-307 2.62e-23

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 95.35  E-value: 2.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 190 QTAFDIGTGSGVLAAILAKQGIpSVIGTDTNPKAVACARANIARLGF-EKQVEIRETDLFpEGFA----DLIVCNPPWLP 264
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKNGK-KVVGVDINPYAVECAKCNAKLNNIrNNGVEVIRSDLF-EPFRgdkfDVILFNPPYLP 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488169315 265 AKPTSAVES----ALYDPESAM--LAAFLRDAPKHLNPDGEIRLIISDL 307
Cdd:PRK14968 103 TEEEEEWDDwlnyALSGGKDGRevIDRFLDEVGRYLKPGGRILLLQSSL 151
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 180-345 5.47e-21

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 90.59  E-value: 5.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 180 LLAH-APSTGFQTAFDIGTGSGVLAAILAKQGIP-SVIGTDTNPKAVACARANIARLGFEKQVEIRETDL------FPEG 251
Cdd:COG4123   28 LLAAfAPVKKGGRVLDLGTGTGVIALMLAQRSPGaRITGVEIQPEAAELARRNVALNGLEDRITVIHGDLkefaaeLPPG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 252 FADLIVCNPPWLPAK-----PTSAVESALYDpESAMLAAFLRDAPKHLNPDGEIRLIISdlAEHLglrpADFLEkAFIRA 326
Cdd:COG4123  108 SFDLVVSNPPYFKAGsgrksPDEARAIARHE-DALTLEDLIRAAARLLKPGGRFALIHP--AERL----AEILA-ALRKY 179

                        170
                 ....*....|....*....
gi 488169315 327 GLRVADMMKTKPKHKKAAN 345
Cdd:COG4123  180 GLGPKRLRPVHPRPGKPAK 198
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 181-329 1.34e-20

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 90.22  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 181 LAHAPSTGFQTAFDIGTGSGVLAAILAKQgIP--SVIGTDTNPKAVACARANiARLGFEKQVEIRETDLF---PEGFADL 255
Cdd:PRK09328 101 LEALLLKEPLRVLDLGTGSGAIALALAKE-RPdaEVTAVDISPEALAVARRN-AKHGLGARVEFLQGDWFeplPGGRFDL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 256 IVCNPPWLPA--KPTSAVESALYDPESAMLA-----AFLR----DAPKHLNPDGeiRLIIsdlaEHlGLRPADFLEKAFI 324
Cdd:PRK09328 179 IVSNPPYIPEadIHLLQPEVRDHEPHLALFGgedglDFYRriieQAPRYLKPGG--WLLL----EI-GYDQGEAVRALLA 251


                 ....*
gi 488169315 325 RAGLR 329
Cdd:PRK09328 252 AAGFA 256
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 168-323 6.55e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 83.02  E-value: 6.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  168 GVFSPLRgeyLD-----LLAHAPSTGFQTAFDIGTGSGVLAAILAKQGiP--SVIGTDTNPKAVACARANIARLGFEKqV 240
Cdd:pfam05175   9 GVFSHGR---LDigsrlLLEHLPKDLSGKVLDLGCGAGVLGAALAKES-PdaELTMVDINARALESARENLAANGLEN-G 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  241 EIRETDLF---PEGFADLIVCNPPWLPAKPT--SAVEsalydpesamlaAFLRDAPKHLNPDGEIRLIISdlaEHLGLRP 315
Cdd:pfam05175  84 EVVASDVYsgvEDGKFDLIISNPPFHAGLATtyNVAQ------------RFIADAKRHLRPGGELWIVAN---RFLGYPP 148


                  ....*...
gi 488169315  316 AdfLEKAF 323
Cdd:pfam05175 149 L--LEELF 154
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
176-335 3.14e-17

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 80.99  E-value: 3.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 176 EYLDLLAHAPstgfQTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRETDLFPEGFADL 255
Cdd:COG2264  140 EALEKLLKPG----KTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLEDGPYDL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 256 IVCNppwLPAKPtsavesalydpesamLAAFLRDAPKHLNPDGeiRLIISD-LAEHlglrpADFLEKAFIRAGLRVADMM 334
Cdd:COG2264  216 VVAN---ILANP---------------LIELAPDLAALLKPGG--YLILSGiLEEQ-----ADEVLAAYEAAGFELVERR 270


                 .
gi 488169315 335 K 335
Cdd:COG2264  271 E 271
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 194-298 3.49e-15

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 75.08  E-value: 3.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAAILAkQGIP--SVIGTDTNPKAVACARANIARLGFEKQVEIRETDLF---PEGFADLIVCNPPWLPAK-P 267
Cdd:TIGR00536 120 DLGTGSGCIALALA-YEFPnaEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFeplAGQKIDIIVSNPPYIDEEdL 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 488169315  268 TSAVESALYDPESAMLAA---------FLRDAPKHLNPDG 298
Cdd:TIGR00536 199 ADLPNVVRFEPLLALVGGddglnilrqIIELAPDYLKPNG 238
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 194-298 5.06e-14

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 71.39  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAaILAKQGIPS--VIGTDTNPKAVACARANIARLGFEKQVEIRETDLF---PEGFADLIVCNPPWLPAKPT 268
Cdd:TIGR03533 127 DLCTGSGCIA-IACAYAFPEaeVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFaalPGRKYDLIVSNPPYVDAEDM 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 488169315  269 SAV-ESALYDPESAmLAA----------FLRDAPKHLNPDG 298
Cdd:TIGR03533 206 ADLpAEYHHEPELA-LASgedgldlvrrILAEAADHLNENG 245
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
190-335 5.28e-14

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 70.95  E-value: 5.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 190 QTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRETDLfpegFADLIVCNppwlpakpts 269
Cdd:PRK00517 121 KTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAELNGVELNVYLPQGDL----KADVIVAN---------- 186

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488169315 270 avesALYDPesamLAAFLRDAPKHLNPDGeiRLIISD-LAEHlglrpADFLEKAFIRAGLRVADMMK 335
Cdd:PRK00517 187 ----ILANP----LLELAPDLARLLKPGG--RLILSGiLEEQ-----ADEVLEAYEEAGFTLDEVLE 238
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 188-305 3.88e-12

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 66.14  E-value: 3.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  188 GFQTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRETDLFPEGFADLIVCNppwlpakp 267
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEKADVVVAN-------- 232

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 488169315  268 tsavesALYDPesamLAAFLRDAPKHLNPDGeiRLIIS 305
Cdd:pfam06325 233 ------ILADP----LIELAPDIYALVKPGG--YLILS 258
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 194-298 7.25e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.04  E-value: 7.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFekQVEIRETDL----FPEGFADLIVCNppwlpakpts 269
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAedlpFPDGSFDLVVSS---------- 70

                          90       100
                  ....*....|....*....|....*....
gi 488169315  270 AVESALYDPEsamLAAFLRDAPKHLNPDG 298
Cdd:pfam13649  71 GVLHHLPDPD---LEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 180-306 3.41e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.03  E-value: 3.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 180 LLAHAPSTGfqTAFDIGTGSGVLAAILAKQGIpSVIGTDTNPKAVACARANIARLGfekqVEIRETDL----FPEGFADL 255
Cdd:COG2227   18 LARLLPAGG--RVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAELN----VDFVQGDLedlpLEDGSFDL 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488169315 256 IVCNppwlpakptSAVESaLYDPEsamlaAFLRDAPKHLNPDGeiRLIISD 306
Cdd:COG2227   91 VICS---------EVLEH-LPDPA-----ALLRELARLLKPGG--LLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 179-322 3.52e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.39  E-value: 3.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 179 DLLAHAPSTGFQTAFDIGTGSGVLAAILAKQGiPSVIGTDTNPKAVACARANIARLGFekQVEIRETDL----FPEGFAD 254
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERG-ARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAedlpFPDGSFD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488169315 255 LIVCNppwlpakptSAVEsALYDPEsAMLAAFLRdapkHLNPDGeiRLIISDLAEHLGLRPADFLEKA 322
Cdd:COG2226   90 LVISS---------FVLH-HLPDPE-RALAEIAR----VLKPGG--RLVVVDFSPPDLAELEELLAEA 140
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 171-309 7.12e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 61.09  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 171 SPLRGEYLDLLAHAPSTGfqTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFeKQVEIRETDL--- 247
Cdd:COG0500   11 LPGLAALLALLERLPKGG--RVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLael 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488169315 248 --FPEGFADLIVCNppwlpakptsaveSALYDPESAMLAAFLRDAPKHLNPDGEIRLIISDLAE 309
Cdd:COG0500   88 dpLPAESFDLVVAF-------------GVLHHLPPEEREALLRELARALKPGGVLLLSASDAAA 138
PRK14967 PRK14967
putative methyltransferase; Provisional
 168-267 8.36e-11

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 61.22  E-value: 8.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 168 GVFSPLRGEYL--DLLAHAPSTGFQTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEkqVEIRET 245
Cdd:PRK14967  14 GVYRPQEDTQLlaDALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD--VDVRRG 91

                         90       100
                 ....*....|....*....|....*
gi 488169315 246 DL---FPEGFADLIVCNPPWLPAKP 267
Cdd:PRK14967  92 DWaraVEFRPFDVVVSNPPYVPAPP 116
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
179-334 1.06e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 60.01  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 179 DLLAHAPSTGFQTAFDIGTGSGVLAAILAKQGIpSVIGTDTNPKAVACARANIARLGFEKQvEIRETDLFPEGFaDLIVC 258
Cdd:COG4976   37 ELLARLPPGPFGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREKGVYDRLLVA-DLADLAEPDGRF-DLIVA 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488169315 259 NppwlpakptsavESALYDPEsamLAAFLRDAPKHLNPDGeiRLIIS---DLAEHLGLRPADFLEKAFIRAGLRVADMM 334
Cdd:COG4976  114 A------------DVLTYLGD---LAAVFAGVARALKPGG--LFIFSvedADGSGRYAHSLDYVRDLLAAAGFEVPGLL 175
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
194-303 3.64e-10

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 60.72  E-value: 3.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 194 DIGTGSGVLAAILAKQGiPSV--IGTDTNPKAVACARANIARLGFEKQVeiRETDLFP--EGFADLIVCNPPWLPAKPTS 269
Cdd:PRK09489 202 DVGCGAGVLSAVLARHS-PKIrlTLSDVSAAALESSRATLAANGLEGEV--FASNVFSdiKGRFDMIISNPPFHDGIQTS 278

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488169315 270 --AVESalydpesamlaaFLRDAPKHLNPDGEIRLI 303
Cdd:PRK09489 279 ldAAQT------------LIRGAVRHLNSGGELRIV 302
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
190-258 1.29e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 57.74  E-value: 1.29e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488169315 190 QTAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRETD----LFPEGfADLIVC 258
Cdd:COG4076   37 DVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADatdlDLPEK-ADVIIS 108
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 191-304 2.28e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.36  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 191 TAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEK----QVEIRETDLFPEGFADLIVCNPPwlpak 266
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNvevlKGDAEELPPEADESFDVIISDPP----- 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488169315 267 ptsavesalYDPESAMLAAFLRDAPKHLNPDGEIRLII 304
Cdd:cd02440   76 ---------LHHLVEDLARFLEEARRLLKPGGVLVLTL 104
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 194-306 2.36e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 55.71  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 194 DIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRE---TDLFPEGFADLIVCnppwlpakptsa 270
Cdd:COG2230   57 DIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLadyRDLPADGQFDAIVS------------ 124

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488169315 271 VESALYDPEsAMLAAFLRDAPKHLNPDGeiRLIISD 306
Cdd:COG2230  125 IGMFEHVGP-ENYPAYFAKVARLLKPGG--RLLLHT 157
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 196-321 2.14e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 53.03  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 196 GTGSGVLAAILakQGIPsVIGTDTNPKAVACARANIARLGFEKQVEIRE--TDL-FPEGFADLIVCNPPWlpAKPTSAVE 272
Cdd:COG1041   36 GTGTILIEAGL--LGRR-VIGSDIDPKMVEGARENLEHYGYEDADVIRGdaRDLpLADESVDAIVTDPPY--GRSSKISG 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488169315 273 SALYDpesaMLAAFLRDAPKHLNPDGeiRLII------SDLAEHLGLRPADFLEK 321
Cdd:COG1041  111 EELLE----LYEKALEEAARVLKPGG--RVVIvtprdiDELLEEAGFKVLERHEQ 159
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 194-259 2.77e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 2.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488169315  194 DIGTGSGVLAAILAKQGiPSVIGTDTNPKAVACARANIARLGFEKQVEiRETDL-FPEGFADLIVCN 259
Cdd:pfam08241   2 DVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGLTFVVG-DAEDLpFPDNSFDLVLSS 66
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 193-342 4.24e-08

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 54.87  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 193 FDIGTGSGVLA-AILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVEIRETDLF----PEGFaDLIVCNPPWLP--A 265
Cdd:PRK01544 143 LELGTGSGCIAiSLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFenieKQKF-DFIVSNPPYIShsE 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 266 KPTSAVESALYDPESAMLAA---------FLRDAPKHLNPDGEIRLIIsdlaehlGLRPADFLEKAFIRAGLRVADMMKT 336
Cdd:PRK01544 222 KSEMAIETINYEPSIALFAEedglqayfiIAENAKQFLKPNGKIILEI-------GFKQEEAVTQIFLDHGYNIESVYKD 294


                 ....*.
gi 488169315 337 KPKHKK 342
Cdd:PRK01544 295 LQGHSR 300
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 194-330 5.37e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 51.66  E-value: 5.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAAILAKQGiPSVIGTDTNPKAVACARANIARLGFEkqveiRETDLFPEGFADLIVCNppwlpakptsAVES 273
Cdd:pfam13489  28 DFGCGTGIFLRLLRAQG-FSVTGVDPSPIAIERALLNVRFDQFD-----EQEAAVPAGKFDVIVAR----------EVLE 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488169315  274 ALYDPESAMLAAFlrdapKHLNPDGeiRLIISDLA-------------------EHLGLRPADFLEKAFIRAGLRV 330
Cdd:pfam13489  92 HVPDPPALLRQIA-----ALLKPGG--LLLLSTPLasdeadrlllewpylrprnGHISLFSARSLKRLLEEAGFEV 160
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 214-261 8.46e-08

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 53.57  E-value: 8.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488169315 214 VIGTDTNPKAVACARANIARLGFEKQVEIRETDLF---PEGFADLIVCNPP 261
Cdd:COG0116  253 IFGSDIDPRAIEAARENAERAGVADLIEFEQADFRdlePPAEPGLIITNPP 303
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
191-306 1.49e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.05  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 191 TAFDIGTGSGVLAAILAKQGIP-SVIGTDTNPKAVACARANIARLGFEkQVEIRetDLFPEGFADLIVCNppwlpakpts 269
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGaRVTGVDLSPEMLARARARLPNVRFV-VADLR--DLDPPEPFDLVVSN---------- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488169315 270 aveSALY---DPEsAMLAAFLRdapkHLNPDGeiRLIISD 306
Cdd:COG4106   71 ---AALHwlpDHA-ALLARLAA----ALAPGG--VLAVQV 100
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 181-261 4.10e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 51.33  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 181 LAHAPSTGFQTAFDIGTGSGVLAAILAKQGIpSVIGTDTNPKAVACARANIARLGFeKQVEIRETDLF---PEGF----A 253
Cdd:COG2265  226 LEWLDLTGGERVLDLYCGVGTFALPLARRAK-KVIGVEIVPEAVEDARENARLNGL-KNVEFVAGDLEevlPELLwggrP 303


                 ....*...
gi 488169315 254 DLIVCNPP 261
Cdd:COG2265  304 DVVVLDPP 311
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
191-262 8.10e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 49.13  E-value: 8.10e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488169315 191 TAFDIGTGSGVLAAILAKQGIPSVIGTDTNPKAVACARANIARLGFEKQVeIRE--TDLFPEGFADLIVCNPPW 262
Cdd:COG2263   48 TVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLGVRVDF-IRAdvTRIPLGGSVDTVVMNPPF 120
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 194-340 8.48e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.18  E-value: 8.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  194 DIGTGSGVLAAILAKQGIPS--VIGTDTNPKAVACARANIARLGFEK-QVEIRETDLFPEGFA----DLIVCNppwlpak 266
Cdd:pfam13847   9 DLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNvEFEQGDIEELPELLEddkfDVVISN------- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488169315  267 ptsAVESALYDPESAmlaafLRDAPKHLNPDGeiRLIISDLAEHLGLrPADFLEKAFIRAGLRVADMMKTKPKH 340
Cdd:pfam13847  82 ---CVLNHIPDPDKV-----LQEILRVLKPGG--RLIISDPDSLAEL-PAHVKEDSTYYAGCVGGAILKKKLYE 144
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 190-257 6.42e-06

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 47.08  E-value: 6.42e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488169315 190 QTAFDIGTGSGVLAAILAKQGIPS--VIGTDTNPKAVACARANIARLGFEKQVEIRETDL---FPEGFADLIV 257
Cdd:COG2519   93 ARVLEAGTGSGALTLALARAVGPEgkVYSYERREDFAEIARKNLERFGLPDNVELKLGDIregIDEGDVDAVF 165
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 193-298 9.24e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 43.90  E-value: 9.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  193 FDIGTGSGVLAAILAKQGIPS-VIGTDTNPKAVACARANIARLGFEK--QVEIRETDLF---PEGFaDLIVCNppwlpak 266
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGeldPGSF-DVVVAS------- 72

                          90       100       110
                  ....*....|....*....|....*....|..
gi 488169315  267 ptsAVESALYDPEsamlaAFLRDAPKHLNPDG 298
Cdd:pfam08242  73 ---NVLHHLADPR-----AVLRNIRRLLKPGG 96
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 198-306 3.71e-05

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 43.88  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315  198 GSGVL---AAILAKQGIP---------SVIGTDTNPKAVACARANIARLGFEKQVEIRETDL----FPEGFADLIVCNPP 261
Cdd:pfam01170  38 GSGTIlieAALMGANIAPgkfdarvraPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAadlpLLEGSVDVIVTNPP 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 488169315  262 W---LPAKPtsAVEsALYDpesamlaAFLRDAPKHLNPDGEIRLIISD 306
Cdd:pfam01170 118 YgirLGSKG--ALE-ALYP-------EFLREAKRVLRGGGWLVLLTAE 155
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 180-263 3.72e-05

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 45.46  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 180 LLAHAPSTGfqTAFDIGTGSGVLAAILAKQGIPSVI-GTDTNPKAVACARANIARLGfeKQVEIR-----ETDLFPEGFA 253
Cdd:PRK14966 245 VLARLPENG--RVWDLGTGSGAVAVTVALERPDAFVrASDISPPALETARKNAADLG--ARVEFAhgswfDTDMPSEGKW 320

                         90
                 ....*....|
gi 488169315 254 DLIVCNPPWL 263
Cdd:PRK14966 321 DIIVSNPPYI 330
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 178-254 6.78e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 43.15  E-value: 6.78e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488169315 178 LDLLAHAPStgfQTAFDIGTGSGVLAAILAKQGiPSVIGTDTNPKAVACARANIARLGFEkQVEIRETDLFpEGFAD 254
Cdd:COG2518   59 LEALDLKPG---DRVLEIGTGSGYQAAVLARLA-GRVYSVERDPELAERARERLAALGYD-NVTVRVGDGA-LGWPE 129
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 207-262 2.89e-04

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 42.87  E-value: 2.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488169315 207 AKQGI----PSVIGTDTNPKAVACARANIARLGFEKQVEIRETDL------FPEGFADLIVCNPPW 262
Cdd:PRK11783 248 ARAGLaelpSKFYGSDIDPRVIQAARKNARRAGVAELITFEVKDVadlknpLPKGPTGLVISNPPY 313
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
176-246 1.12e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 39.66  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488169315  176 EYLDLLAHApstgfqTAFDIGTGSGVLAAILAK--QGIPSVIGTDTNPKAVACARANIARLGFEkQVEIRETD 246
Cdd:pfam01135  67 ELLELKPGM------RVLEIGSGSGYLTACFARmvGEVGRVVSIEHIPELVEIARRNLEKLGLE-NVIVVVGD 132
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 218-261 1.17e-03

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 39.29  E-value: 1.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488169315 218 DTNPKAVACARANIARLGFEKQVEIRETDLF-------PEGFaDLIVCNPP 261
Cdd:COG0742   71 EKDRKAAAVIRKNLEKLGLEDRARVIRGDALrflkrlaGEPF-DLVFLDPP 120
arsM PRK11873
arsenite methyltransferase;
191-259 3.13e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 38.78  E-value: 3.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488169315 191 TAFDIGTGSGVLAAILAKQGIPS--VIGTDTNPKAVACARANIARLGFEkQVEIRETDL----FPEGFADLIVCN 259
Cdd:PRK11873  80 TVLDLGSGGGFDCFLAARRVGPTgkVIGVDMTPEMLAKARANARKAGYT-NVEFRLGEIealpVADNSVDVIISN 153
PRK11727 PRK11727
23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF;
172-261 4.18e-03

23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF;


Pssm-ID: 236964  Cd Length: 321  Bit Score: 38.69  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488169315 172 PLRGEYL----DLLA-----HAPSTGFQTAFDIGTGSGVLAAILAKQ--GIpSVIGTDTNPKAVACARANIAR-LGFEKQ 239
Cdd:PRK11727  89 PGRADYIhhlaDLLAednggVIPRGANVRVLDIGVGANCIYPLIGVHeyGW-RFVGSDIDPQALASAQAIISAnPGLNGA 167

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488169315 240 VEIR--------------ETDLFpegfaDLIVCNPP 261
Cdd:PRK11727 168 IRLRlqkdskaifkgiihKNERF-----DATLCNPP 198
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 194-255 4.71e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 38.61  E-value: 4.71e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488169315 194 DIGTGSG---VLAAILAKQGipSVIGTDTNPKAVACARANIARLGFeKQVEIRETDLfPEGFADL 255
Cdd:COG2242  253 DIGAGSGsvsIEAARLAPGG--RVYAIERDPERAALIRANARRFGV-PNVEVVEGEA-PEALADL 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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