|
Name |
Accession |
Description |
Interval |
E-value |
| EmrB |
NF000391 |
multidrug efflux MFS transporter permease subunit EmrB; |
3-503 |
0e+00 |
|
multidrug efflux MFS transporter permease subunit EmrB;
Pssm-ID: 411083 [Multi-domain] Cd Length: 501 Bit Score: 1007.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 3 QKPLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFL 82
Cdd:NF000391 1 RKPLEGAQLAWMTIALSLATFMQVLDSTIANVAIPTIAGNLGASNSQGTWVITSFGVANAISIPITGWLAKRIGEVKLFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 83 WSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISD 162
Cdd:NF000391 81 WSTALFALASWLCGISNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTVIVAPICGPILGGYISD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 163 NYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVV 242
Cdd:NF000391 161 NYHWGWIFFINVPIGIAVVLLTLQTLRGRETKTEIRPIDTVGLVLLVVGIGSLQIMLDQGKELDWFNSTEIIVLTVVAVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 243 AITFLIVWELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPL 322
Cdd:NF000391 241 ALSFLIVWELTDDHPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGLIPVLLSPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 323 IGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSN 402
Cdd:NF000391 321 IGRFGHKLDMRRLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSN 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 403 FMRTLAGSIGTSITTTLWTQRESLHHAQLTEFVNPYNPNATQAYQELEKLGMSQQQASAYLAREITNQGLIISANEIFWL 482
Cdd:NF000391 401 FTRTLAGSIGTSITTTLWTQRESMHHSQLTESINPYNPNAQQMYQQLEQLGMSQQQASAYIAQQITNQGLIISANEIFWL 480
|
490 500
....*....|....*....|.
gi 488137538 483 SAGVFLMLLALIWFARPPFTS 503
Cdd:NF000391 481 SAGVFLILLVLVWFAKPPFSA 501
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-497 |
0e+00 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 615.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 14 MTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASW 93
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 94 LCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFIN 173
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 174 IPIGLVVVLLAGSTLKgRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIVWELT 253
Cdd:TIGR00711 163 VPIGIIVVVVAFFILP-RDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 254 DDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMR 333
Cdd:TIGR00711 242 DDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 334 QLVTFSFIMYAVCFYWRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGT 413
Cdd:TIGR00711 322 KLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGT 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 414 SITTTLWTQRESLHHAQLTEFVNPYNPNATQAYQELEKLGMSQQQASAYLAREITNQGLIISANEIFWLSAGVFLMLLAL 493
Cdd:TIGR00711 402 ALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLIL 481
|
....
gi 488137538 494 IWFA 497
Cdd:TIGR00711 482 IWFL 485
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-498 |
8.88e-121 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 359.20 E-value: 8.88e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 LVVVLLAgstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivweltddhP 257
Cdd:cd17503 161 ILALLLA------------------------------------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 VIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVT 337
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 338 FSFIMYAVCFYWRAYtFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITT 417
Cdd:cd17503 249 AGLLLLALGTLLLAF-LTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 418 TLWTQRESLHHAQLTEfvnpynpnatqayqeleklgmsqqqasaYLAREITNQGLIISANEIFWLSAGVFLMLLALIWFA 497
Cdd:cd17503 328 TLLTNRTQFHHSRLSE----------------------------LLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
|
.
gi 488137538 498 R 498
Cdd:cd17503 380 R 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-427 |
6.23e-64 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 212.42 E-value: 6.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 LVVVLLAgstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivweltddhp 257
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 vidlslfksRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVT 337
Cdd:cd17321 168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 338 FSFIMYAVCFYWRAYTFePGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITT 417
Cdd:cd17321 239 AGLLLTAVGLLLLALLG-ADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
410
....*....|
gi 488137538 418 TLWTQRESLH 427
Cdd:cd17321 318 ALLTAGLSAN 327
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-420 |
9.54e-49 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 171.21 E-value: 9.54e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGtWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 Lvvvllagstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivweltddhp 257
Cdd:cd17502 160 G------------------------------------------------------------------------------- 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 vidLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRID-MRQLV 336
Cdd:cd17502 161 ---LALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLI 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 337 TFSFIMYAVCFYWrAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSIT 416
Cdd:cd17502 238 VIGTILMSVGAGL-LTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT 316
|
....
gi 488137538 417 TTLW 420
Cdd:cd17502 317 DVFL 320
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-411 |
1.15e-48 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 171.31 E-value: 1.15e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 12 AWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLA 91
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFF 171
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 172 INIPIGLVVVLLAGSTLKGRETKTEIRPIDTIglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivwe 251
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSL------------------------------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 252 ltddhpvidLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRID 331
Cdd:COG2814 201 ---------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 332 MRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSI 411
Cdd:COG2814 272 RRRLLLIGLLLLALGLLLLALAGSLWLLLLAL----FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
13-499 |
2.82e-39 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 149.11 E-value: 2.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQV-LDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLA 91
Cdd:PRK14995 5 WLTLVIIVLVYIPVaIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAK-RSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIF 170
Cdd:PRK14995 85 SLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 171 FINIPIGLVVVLLAGSTLKGRETKTEiRPIDTIGLVLLVVGIgaLQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIV- 249
Cdd:PRK14995 165 LINVPIVLVVMGLTARYVPRQAGRRD-QPLNLGHALMLIVAI--LLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIr 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 250 WELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHR 329
Cdd:PRK14995 242 TQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 330 IDMRQLVTFSFIMYAVCFYWRAYTfepgmDFGASAWPQF----FQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMR 405
Cdd:PRK14995 322 LGLRLVATGGMALSALSFYGLAMT-----DFSTQQWQAWglmaLLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAY 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 406 TLAGSIGTSITTTLWTQRESlhhaqlTEFVNPYNPNATQAYQELEKLGMSQQQASA---YLAREITN---QGLIISANEI 479
Cdd:PRK14995 397 ELGAGLGIAIFGLLLSRSYS------ASIRLPAGLPAQLIEKASSSIGEAVQLANSlppTLGQALLDaakQAFIWSHSVV 470
|
490 500
....*....|....*....|
gi 488137538 480 FWLSAGVFLMLLALIWFARP 499
Cdd:PRK14995 471 LSSAGSMLLLLAVGVWFSLA 490
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
23-415 |
6.62e-39 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 147.57 E-value: 6.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 23 FMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLG 102
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 103 MLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVL 182
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 183 LAGSTLKGRETKTeiRPIDTIGLVLLVVGIGALQIMLDQGKELDwFNSTEIIVLTVVAVVAITFLIVWELTDDHPVIDLS 262
Cdd:PRK10504 180 ATLMLMPNYTMQT--RRFDLSGFLLLAVGMATLTLALDGSKGLG-LSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 263 LFKSRNFTIGCLCLSLAY----MLYFgaivLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTF 338
Cdd:PRK10504 257 LFRTRTFSLGLAGSFAGRigsgMLPF----MTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVA 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488137538 339 SFIMYAVCFYWRAYTFEPGMDFgASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSI 415
Cdd:PRK10504 333 TTLGLALVSLLFMLVALLGWYY-LLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTI 408
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
18-419 |
3.80e-38 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 143.49 E-value: 3.80e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGlVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17504 81 APNLPVLIAGRALQG-IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 LVVVLLAgstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivweltddhP 257
Cdd:cd17504 160 VLLAALV------------------------------------------------------------------------P 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 VIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQE----VYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMR 333
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 334 QLVTFSFIMYAVCFYWRAYTfepGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGT 413
Cdd:cd17504 248 RVLLIGLVISAVGLLLLALL---HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
....*.
gi 488137538 414 SITTTL 419
Cdd:cd17504 325 AIAGAI 330
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
16-423 |
1.11e-36 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 142.00 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGDLGSSnSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLC 95
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 96 GMSNSLGMLIFFRVIQGlVAGPLIPLSQSLLLNNYPPAKRSMALAlwSMTIVVAP--IFGPILGGYISDNYH--WGWIFF 171
Cdd:cd06179 80 GTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQG--VVNLVASPgsALGPLIAGALVEANAagWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 172 INIPI-GLVVVLLAGS-------TLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVA 243
Cdd:cd06179 157 INAIFnALALILLFFFyhppprpQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 244 ITFLIVWEL--TDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSP 321
Cdd:cd06179 237 LIAFGLYEWkgTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 322 LIGRFAHRI-DMRQLVTFSFIMYAVcFYWRAYTFEPGMDFGASAWpQFFQGFAIACFFMPLTTITLSGLPPERMAAASSL 400
Cdd:cd06179 317 LAGLLLTKIkHIKWQLVAGFVLFTA-FLALLALITPDNKALAIAF-SVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394
|
410 420
....*....|....*....|...
gi 488137538 401 SNFMRTLAGSIGTSITTTLWTQR 423
Cdd:cd06179 395 LGSARALGGAVGTAIFTSILSNR 417
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-250 |
8.32e-34 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 129.55 E-value: 8.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 2 AQKPLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLF 81
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 82 LWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYIS 161
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 162 DNYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAV 241
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242
|
....*....
gi 488137538 242 VAITFLIVW 250
Cdd:COG0477 243 LALLLLALL 251
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
16-412 |
1.43e-33 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 130.77 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLC 95
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 96 GMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDnYHWGWIFFinIP 175
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFF--LL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 176 IGLVVVLLAGSTLKGRETKTEIRPIDTIGLvllvvgigalqimldqgkeLDWFNSTEIIVLTVVAVVAITFLIvweltdd 255
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKL-------------------RDLKKALRGRGLLTFLVSAFLYFF------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 256 hpvidlslfksrnftigclclslaymLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRF-AHRIDMRQ 334
Cdd:cd17474 213 --------------------------LYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 335 LVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIG 412
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIAI----VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-413 |
7.47e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 122.53 E-value: 7.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIP-TIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCG 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 97 MSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPI 176
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 177 GLVVVllagstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteIIVLTVVAVVAITFLIVWELTDDH 256
Cdd:pfam07690 161 SLLAA---------------------------------------------------VLLLLPRPPPESKRPKPAEEARLS 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 257 PVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPqLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLV 336
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488137538 337 TFSFIMYAVCfYWRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGT 413
Cdd:pfam07690 269 LLALLLLILA-ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-416 |
3.21e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.43 E-value: 3.21e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 93 WLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFI 172
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 173 NIPIGLVVVLLagstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivwel 252
Cdd:COG2271 170 LGLPGLLLALL--------------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 253 tddhpvidlslfksrNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRID- 331
Cdd:COG2271 181 ---------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGr 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 332 -MRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGS 410
Cdd:COG2271 246 rRKLVLAIGLLLAALALLLLALLPSPALAIALL----FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
....*.
gi 488137538 411 IGTSIT 416
Cdd:COG2271 322 LGPLLV 327
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-420 |
1.19e-27 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 114.21 E-value: 1.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 30 TIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRV 109
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 110 IQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLK 189
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 190 grETKTEIRPIDTIGLVLLVVGigalqimldqgkeldwfnsteiivltvvavvaitflivweltddhpvidlSLFKSRNF 269
Cdd:cd17320 176 --ETLPEEKRKPLLSSLLRAYK--------------------------------------------------RVLKNRRF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 270 TIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVC-FY 348
Cdd:cd17320 204 LGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAaLV 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488137538 349 WRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLpPERMAAASSLSNFMRTLAGSIGTSITTTLW 420
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
18-422 |
2.80e-25 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 106.96 E-value: 2.80e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAK-RSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINipi 176
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL--- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 177 glvvvllagstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteIIVLTVVAVVAItflivweltddh 256
Cdd:cd17476 160 --------------------------------------------------------AILAAIVAVAAI------------ 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 257 pvidlsLFKSRNFTIGCLCLSLAYMlYFGAIVL-LPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQL 335
Cdd:cd17476 172 ------FWTSPSFIAVLLAVFLGWA-SFGIWVFyATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYI 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 336 VTFSFIMYAVcfywrAYTFEPGMDFGASAWPQFFQGFAIACF-----FMPLTTITLSGLPPERMAAASSLSNFMRTLAGS 410
Cdd:cd17476 245 MAISMVAFLV-----GPILFATMPVHQTYWAQAFPAMIVAPFgmdfsFPAATIIASNAVPREYQGLAGSLVNTVVNYGIS 319
|
410
....*....|..
gi 488137538 411 IGTSITTTLWTQ 422
Cdd:cd17476 320 IGLGIAGTVETS 331
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-412 |
2.29e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.58 E-value: 2.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 LVVVLLAGSTLKGRETKTEIRPIDtiglvllvvgigalqimldqgkeldwfnsteiivltvvavVAITFLIVWELTDDHP 257
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVS----------------------------------------AARLRSGLRLLLRDRR 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 VidlslfksrnftIGCLCLSLAYMLYFGAI-VLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLV 336
Cdd:cd17325 201 L------------LALFLAIFVLAFAFGALePFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 337 TFSFIMYAVCFYWRAYTfepgMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIG 412
Cdd:cd17325 269 LIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-429 |
5.65e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 5.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 178 LVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVGIGalqimldqgkeldwfnsteiivltvvavvaitflivweltddhp 257
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 258 vidLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHR-IDMRQLV 336
Cdd:cd06174 197 ---KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 337 TFSFIMYAVCFYWRAYtfepGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSIT 416
Cdd:cd06174 274 LIGLLLMALGLALLLL----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
410
....*....|...
gi 488137538 417 TTLWTQRESLHHA 429
Cdd:cd06174 350 GFLLAATFGLTGA 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-183 |
1.11e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.60 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 15 TVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINI 174
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
....*....
gi 488137538 175 PIGLVVVLL 183
Cdd:cd17324 161 VLALLAALL 169
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
15-184 |
2.63e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 86.48 E-value: 2.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 15 TVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINI 174
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|
gi 488137538 175 PIGLVVVLLA 184
Cdd:cd17323 161 IISGFCLILI 170
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-419 |
1.16e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.93 E-value: 1.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 12 AWMTVALS-LATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVL 90
Cdd:COG2223 3 RWRVLLLAtLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 91 ASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIF 170
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 171 FInipiglvvvllagstlkgretkteirpidtIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLtvvavvaitflivw 250
Cdd:COG2223 163 LI------------------------------LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 251 eltddhpvidLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRI 330
Cdd:COG2223 199 ----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 331 DMRQLVTFSFIMYAVCFYWRAYTFEPgmdfgasaWPQFFQGFAIACFFMPLTTITLSGL-----PPERMAAASSLSNFMR 405
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALALGS--------LWLFLVLFLLLGLALGGGNGAVFALvpdifPTKNAGAVYGLVGAAG 340
|
410
....*....|....
gi 488137538 406 TLAGSIGTSITTTL 419
Cdd:COG2223 341 GLGGFLGPLLFGAL 354
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-416 |
2.53e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.39 E-value: 2.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92
Cdd:cd17319 3 RIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 93 WLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFI 172
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 173 nipiglvvvllagstlkgretkteirpidtIGLVLLVVGIGALqimldqgkeldwfnsteIIVLTVVAVVAITFLIVWel 252
Cdd:cd17319 163 ------------------------------EGLLGLLLAVLWW-----------------FYLRQVWGLALGYFGINY-- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 253 tddhpvidlslfksrnftigclclslaymLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDM 332
Cdd:cd17319 194 -----------------------------ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 333 ---RQLVTFSFIMYAVCFYWRAYTFEPGMDFGAsawpQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAG 409
Cdd:cd17319 245 garRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL----LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG 320
|
....*..
gi 488137538 410 SIGTSIT 416
Cdd:cd17319 321 FVAPLLI 327
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
51-183 |
2.34e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 75.76 E-value: 2.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 51 TWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNY 130
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488137538 131 PPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
35-299 |
2.04e-14 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 75.86 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 35 AIPTIAGDLGSSNSQGTWViTSFGVANAISIPVTGWLAKRVGEvRLFLWSTGLFVLASWLCG-MSNSLGMLIFFRVIQGL 113
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGR-RPFVIATHIIGLVGAIVGcTANKFNTLLAAMTLLGV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 114 VAGPL--IPLSQSLLLNNyppAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL-------- 183
Cdd:pfam06609 144 AAGPAgaSPLFIGELMSN---KTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLiiiwyhpp 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 184 AGSTLKGRET--KTEIRPIDTIGLVLLVVGIGALQIMLD-QGKELDWFNSTEIIVLTVVAVVAITFLIVWEL--TDDHPV 258
Cdd:pfam06609 221 SFAQLHGKKArkRDELAKLDWIGIFLVIAGTSLFLLGVSwGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVfgKPEQPI 300
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 488137538 259 IDLSLFK-SRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYG 299
Cdd:pfam06609 301 IPPALFKdTRGFVCILIISSIMGAMHLCLTIIYPQQVINIFG 342
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-400 |
4.55e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 4.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDnYHWGWIFFINI 174
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 175 pIGLVVVLLAGSTLKGRETKTEIRPidtiglvllvvgigalqimlDQGKEldwfNSTEIIVLTVVAVVAITFlivweltd 254
Cdd:cd17473 161 -LALPVLILVLLFLPEPARKSKSAA--------------------SPGAA----TAAALPWKRVLPIYFLAF-------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 255 dhpvidlslfksrnftigclclsLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQ 334
Cdd:cd17473 208 -----------------------LAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 335 LVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSL 400
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGA----ILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-184 |
6.42e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.01 E-value: 6.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIG 177
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
....*..
gi 488137538 178 LVVVLLA 184
Cdd:cd17489 161 LLALLLV 167
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
18-189 |
1.84e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 71.88 E-value: 1.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISD-NYHWGWIFFINIPI 176
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVL 163
|
170
....*....|...
gi 488137538 177 GLVVVLLAGSTLK 189
Cdd:cd17328 164 GVLLAILLLLFVR 176
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-419 |
3.85e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.71 E-value: 3.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 15 TVALSLATFMQVLDSTIANVAIPTIA--GDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 93 WLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALAL----WSMTIVVAPIFGPILGGYISDNYHWGW 168
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 169 IFFINIPIGLVVVLLagstlkgretkteirpidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitfli 248
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 249 vweltddhpvidlslfksRNFTIGCLCLSLA-YMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFA 327
Cdd:cd17316 176 ------------------RRRTLLLILLWFFiSFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLS 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 328 HRIDMRQLVTFSFIMYAVCFYwrAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTL 407
Cdd:cd17316 238 DRIGRKKTLVIGLILSGILAL--PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRL 315
|
410
....*....|..
gi 488137538 408 AGSIGTSITTTL 419
Cdd:cd17316 316 GGGGAPPLIALL 327
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
35-415 |
7.33e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 70.11 E-value: 7.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 35 AIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLV 114
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 115 AGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKgrETK 194
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP--ETL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 195 TEIRPIDtiglvllvvgigalqimldqgkeldwfNSTEIIVLtvvavvaitflivweltddhpvidLSLFKSRNFTIGCL 274
Cdd:TIGR00710 185 PYEARIQ---------------------------ISTYFETF------------------------LLLLKSKMFWGYAL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 275 CLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAYTf 354
Cdd:TIGR00710 214 IYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEIT- 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 355 epgMDFGASAWPQFfqgFAIACFFMPLTTITLSGLP-------PERMAAASSLSNFMRTLAGSIGTSI 415
Cdd:TIGR00710 293 ---AILGLGSWAMI---IGPMMFVGIGNSMISSIAMayaledfPHVAGTASALFGTLRLVLGAIVGYL 354
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
34-194 |
9.20e-13 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 69.67 E-value: 9.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 34 VAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGL 113
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 114 VAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLagSTLKGRET 193
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLL--SLFILKET 181
|
.
gi 488137538 194 K 194
Cdd:PRK10473 182 R 182
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-184 |
1.86e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGDL-GSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINI 174
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
170
....*....|
gi 488137538 175 PIGLVVVLLA 184
Cdd:cd17325 362 ALLLLAAVLF 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
35-183 |
3.71e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 68.02 E-value: 3.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 35 AIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLV 114
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488137538 115 AGPLIPLSQSLLLNNYPPAK--RSMALALWSMTIvvAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEfsRMMSFVTLVMTI--APLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL 161
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-184 |
1.99e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.66 E-value: 1.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 11 LAWMTVALSLATFMQVLDSTIANVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVR--LFLWSTGL 87
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 88 FVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWG 167
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170
....*....|....*..
gi 488137538 168 WIFFINIPIGLVVVLLA 184
Cdd:COG2271 338 AAFLLLAALALLAALLA 354
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-188 |
2.76e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.83 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 20 LATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSN 99
Cdd:cd17365 6 LIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 100 SLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLV 179
Cdd:cd17365 86 SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
|
....*....
gi 488137538 180 VVLLAGSTL 188
Cdd:cd17365 166 LLPLLRGTL 174
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-188 |
3.47e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.99 E-value: 3.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALS-LATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLA 91
Cdd:TIGR00895 16 WRAIILSfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFF 171
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170
....*....|....*..
gi 488137538 172 INIPIGLVVVLLAGSTL 188
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFL 192
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-419 |
3.73e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 17 ALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGL-----FVLA 91
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFF 171
Cdd:cd06173 83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 172 INIpIGLVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVGigalqimldqgkeldwfnsteiivltvvavvaitflivwe 251
Cdd:cd06173 163 INA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGL---------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 252 ltddhpvidLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRID 331
Cdd:cd06173 202 ---------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 332 MRQLVTFSFIMYAVCFYWRAYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSI 411
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAAL----FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
....*...
gi 488137538 412 GTSITTTL 419
Cdd:cd06173 349 GALLAGLL 356
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
33-183 |
4.55e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 61.14 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 33 NVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFlwSTGLFV--LASWLCGMSNSLGMLIFFRVI 110
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFM--SAGLLLsaLANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488137538 111 QGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAII 173
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-184 |
4.98e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 61.20 E-value: 4.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 20 LATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSN 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 100 SLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLV 179
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
....*
gi 488137538 180 VVLLA 184
Cdd:TIGR00893 161 WGVLW 165
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-184 |
1.24e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.90 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 40 AGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGpLI 119
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NV 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488137538 120 PLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-183 |
1.91e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 36 IPTIAGDLGSSNsqGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVA 115
Cdd:cd17489 217 LPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 116 GPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-416 |
3.46e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 3.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 14 MTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASW 93
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 94 LCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKR---SMALALWSMTIVVAPIFGpilggyisdnyhwGWIF 170
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLG-------------GLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 171 FINIPIGLVVVLLAgstlkgretkteirpidtIGLVLLVVGIGALQIMLDQGKELDwfnsteiivltvvavvaitflivw 250
Cdd:COG0738 156 LLGLSLSWHLPYLI------------------LAVLLLLLALLFLRSKLPEIEEEE------------------------ 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 251 ELTDDHPVIDLSLFKSRNFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRI 330
Cdd:COG0738 194 EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 331 DMRQLVTFSFIMYAVCFYWRAYTfePGMDFGASAWpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMrTLAGS 410
Cdd:COG0738 274 GPVRLLRLSALLAAVGLLLALLA--PGPWLALIGL--ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGA 348
|
....*.
gi 488137538 411 IGTSIT 416
Cdd:COG0738 349 IGPPLI 354
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
59-423 |
5.42e-09 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 58.47 E-value: 5.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 59 VANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMA 138
Cdd:cd17322 48 IVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 139 LALWSMTIVVAPIFGPILGGYISDNYHWGWIF--------FINIPIGLVVVLL---AGSTLKGRETKTEIRP-------- 199
Cdd:cd17322 128 SAIPSLPYIITTWIGGNIAQAALPNSNWRWGYgmwaiilpLSSLPLVLCLLYMqrkARKDGEIKELKNQETEeqtgglsq 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 200 --------IDTIGLVLLVVGIGA--LQIMLDQGKELDWFNSTeIIVLTVVAVVAITFLIVWELT-DDHPVIDLSLFKSRN 268
Cdd:cd17322 208 nlvklfwkLDIFGVILLTAGLGLilVPLTLAGGAKSKWKNSS-IIAMIVLGGVLLVAFLLWEAKfAKYPFLPFRLLKDRT 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 269 FTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIG---RFAHRidMRQLVTFSFIMYAV 345
Cdd:cd17322 287 ILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGfliRKTRR--YKVLVIIGVPLYIV 364
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 346 CFYWRAYTFEPGMDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTLWTQR 423
Cdd:cd17322 365 GMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQT 442
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
36-347 |
7.00e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 57.58 E-value: 7.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 36 IPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGL-- 113
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAgi 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 114 -VAGPLIPlsqsLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRE 192
Cdd:COG2807 121 aVGNVLLP----GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 193 TKTEIRPidtiglvllvvgigalqimldqgkeldwfnsteiivltvvavvaitflivweltddHPVIDLSLFKSRNFTIG 272
Cdd:COG2807 197 AAAAAAP--------------------------------------------------------AAASLRSLWRSPLAWLL 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 273 CLCLSLAYMLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGILPVLLSPLIGRFAHRI-DMRQLVTFSFIMYAVCF 347
Cdd:COG2807 221 TLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLgDRRPLLLLLGLLGLAGL 295
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
52-184 |
1.07e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.20 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 52 WVITSFGVANAISIPVTG-WLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNY 130
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488137538 131 PPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
33-184 |
2.36e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.08 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 33 NVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQ 111
Cdd:cd06173 228 TVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488137538 112 GLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
33-201 |
2.58e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 55.84 E-value: 2.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 33 NVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQG 112
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 113 LVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGP-ILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGR 191
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170
....*....|
gi 488137538 192 ETKTEIRPID 201
Cdd:TIGR00881 175 PQSCGLPPAE 184
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-184 |
3.14e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.69 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 20 LATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLA-KRVGEVRLFLWSTGLFVLASWLCGMS 98
Cdd:cd17490 202 LAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 99 NSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGL 178
Cdd:cd17490 282 PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIAL 361
|
....*.
gi 488137538 179 VVVLLA 184
Cdd:cd17490 362 LAAILS 367
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-183 |
3.52e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 55.25 E-value: 3.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 15 TVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGM--SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFI 172
Cdd:cd17380 81 TPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|.
gi 488137538 173 NIPIGLVVVLL 183
Cdd:cd17380 161 FGLLGLLWALV 171
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-203 |
8.65e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.10 E-value: 8.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGM 97
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 98 SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYIS-DNYHWGWIFFINIPI 176
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGtAGALPFLIAAVLLLL 160
|
170 180
....*....|....*....|....*..
gi 488137538 177 GLVVVLLAGSTLKGRETKTEIRPIDTI 203
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLL 187
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
31-183 |
1.14e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 53.78 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 31 IANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLG--MLIFFR 108
Cdd:cd17318 39 TDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLR 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488137538 109 VIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:cd17318 119 ILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLL 193
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
28-164 |
1.25e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 53.73 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 28 DSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFF 107
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 108 RVIQGL---VAGPLIPLSQSLLlnnYPPAKRSMALALWSMTIVVApifgpILGGYISdNY 164
Cdd:cd17359 96 RIIGGLavgGASALVPMYIAEV---APAEIRGRLVSLNQLMIVFG-----QLLAYIV-NY 146
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
20-184 |
2.79e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 20 LATFMQVLDSTIANVAIPTIAGDLGSSNSQGT-WVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMS 98
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 99 NSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGL 178
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLA 363
|
....*.
gi 488137538 179 VVVLLA 184
Cdd:cd17473 364 LVLAIV 369
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
19-185 |
2.80e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.58 E-value: 2.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 19 SLATFMQVLDSTIANVAIPTIAGDL--GSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCG 96
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 97 MSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPI 176
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAA 162
|
....*....
gi 488137538 177 GLVVVLLAG 185
Cdd:cd17315 163 VPALLQLLL 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-191 |
3.11e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 10 PLAWmtvALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFV 89
Cdd:COG2807 215 PLAW---LLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 90 LASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTI--VVApIFGPILGGYISD---NY 164
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVgyLLA-ALGPLLVGALHDatgSW 370
|
170 180
....*....|....*....|....*..
gi 488137538 165 HWGWIFFinipIGLVVVLLAGSTLKGR 191
Cdd:COG2807 371 TAALLLL----AALAVLMLVAGLLAGR 393
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
52-402 |
5.68e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 5.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 52 WVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYP 131
Cdd:cd17329 39 LVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTT 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 132 PAKRSMALALWSMTIVVAPIFGPILGGYISDnYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTEIRPIDTIGLVLLVVg 211
Cdd:cd17329 119 PENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIV- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 212 igalqimldqgkeldwfnsteiivltvvavvaitflivweltddhpvidlslFKSRNFTIGCLCLSLAYMLYFGAIVLLP 291
Cdd:cd17329 197 ----------------------------------------------------LRDRAFLLFLLASFLISLIYFQLESTLP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 292 QLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVcfywraytfepgmDFGASAWPQFFQG 371
Cdd:cd17329 225 VYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI-------------GFAVLAFANTLAV 291
|
330 340 350
....*....|....*....|....*....|.
gi 488137538 372 FAIACFFMPLTTITLSglpPERMAAASSLSN 402
Cdd:cd17329 292 LILAMIVLTLGEMLVF---PAVQTLVAALAP 319
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-184 |
1.11e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 24 MQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGM 103
Cdd:cd17371 10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 104 LIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALAL----WSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLV 179
Cdd:cd17371 90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALL 169
|
....*
gi 488137538 180 VVLLA 184
Cdd:cd17371 170 VLFIR 174
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-160 |
1.27e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS-- 92
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLll 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 93 -WLCGMSNSLGMLIFFrVIQGLVAGPLIPLSQSLLLNNYPPAK-------RSMALALWSMTIVVAPIFGPILGGYI 160
Cdd:COG2211 311 lFFLGPGNLWLLLVLA-ALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
41-183 |
3.39e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.58 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 41 GDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMS---NSLGMLIFFRVIQGLVAGP 117
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGG 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488137538 118 LIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILG---GYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:pfam00083 119 ASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIG 187
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-194 |
5.58e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.70 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 16 VALSLATFMQVLDSTIANVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL 94
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 95 CGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNyPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINI 174
Cdd:COG0738 293 ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG-LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
|
170 180
....*....|....*....|
gi 488137538 175 PIGLVVVLLAGSTLKGRETK 194
Cdd:COG0738 372 VCYLLILLLALALKRKRRKK 391
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
33-203 |
6.90e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.39 E-value: 6.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 33 NVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVgEVRLFLwSTGLFVLA------SWLCGMSNSLGMLIF 106
Cdd:cd17345 23 SLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRS-NPKRFL-AIGLILSAiiniliGFVPSATSSVGLMFI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 107 FRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMT-----IVVAPIFGpiLGGYISDNYHWGWIFFINIPIGLVVV 181
Cdd:cd17345 101 LLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIShnvggGLVGPLAG--LGLAIFGDGWWRGAFIFPAIIAIIVA 178
|
170 180
....*....|....*....|..
gi 488137538 182 LLAGSTLKGRETKTEIRPIDTI 203
Cdd:cd17345 179 VIVLFLGKDTPESEGLPPIEEY 200
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-184 |
8.74e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.93 E-value: 8.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 37 PTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAG 116
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 117 PLIPLSQSLLLNNYPPAkRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd17324 303 AAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
30-168 |
1.14e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.59 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 30 TIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRV 109
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488137538 110 IQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISdnYHWGW 168
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLT--TLFGW 161
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
61-183 |
1.22e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 47.61 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 61 NAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGpLIPLSQSLLLNNYPPAKRSMALA 140
Cdd:PRK09874 67 SAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALG 145
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 488137538 141 LWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:PRK09874 146 TLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLV 188
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
202-421 |
1.36e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 202 TIGLVLLVVGIGALQIMLDQGKELDWFNSTEIIVLTVVAVVAITFLIVWEL-TDDHPVIDL-----SLFKSRNFtigcLC 275
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERpVPEEEKVSLkeslkALLKNRPF----LL 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 276 LSLAYMLYFGAI----VLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWrA 351
Cdd:COG2211 233 LLLAYLLFFLALalvaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL-L 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 352 YTFEPGmDFGASAWPQFFQGFAIAcFFMPLTTITLSGLPPE--------RMAAASSLSNFMRTLAGSIGTSITTTLWT 421
Cdd:COG2211 312 FFLGPG-NLWLLLVLAALAGIGLG-AILVLPWAMLADVVDYdewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-154 |
1.47e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 10 PLAWMTVALSLATFMQvldsTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFV 89
Cdd:pfam07690 201 PVLWLLLALLLFGFAF----FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 90 LASW---LCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGP 154
Cdd:pfam07690 277 LAALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-198 |
1.92e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 69 GWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGL--VAGPLIPLSQSLLlnnyPPAKRSMALALWSMTI 146
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgaISSVVMALLADLT----REENRTKAMALIGASI 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488137538 147 VVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRETKTEIR 198
Cdd:cd17472 129 GIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQIS 180
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
35-161 |
2.06e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.84 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 35 AIPTIAGDLGSSnsqgtwvitsFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLV 114
Cdd:cd17390 28 ASPTVIGLIGSV----------YGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIF 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 488137538 115 AGPLiPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYIS 161
Cdd:cd17390 98 KHTQ-SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLA 143
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-185 |
2.66e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.42 E-value: 2.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 23 FMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAIS-IPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSL 101
Cdd:cd17330 185 LIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSV 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 102 GMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVV 181
Cdd:cd17330 265 PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
....
gi 488137538 182 LLAG 185
Cdd:cd17330 345 FLLS 348
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
53-172 |
4.03e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 45.72 E-value: 4.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 53 VITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPP 132
Cdd:cd17391 245 VFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPK 324
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 488137538 133 AKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFI 172
Cdd:cd17391 325 EVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-183 |
4.10e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 45.65 E-value: 4.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 49 QGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLN 128
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 129 NYPPAKRSMALALWSMTIVVAPIFGPILGGYISDnyhWGWI-FFINIPIGLVVVLL 183
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLqLAISLPGLLFLLLL 158
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-192 |
4.13e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 4.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQVLdsTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92
Cdd:COG2223 208 WLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 93 WLCGM-SNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISD---NYHWGW 168
Cdd:COG2223 286 LLLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDatgSYTAAF 365
|
170 180
....*....|....*....|....*
gi 488137538 169 IFFINIP-IGLVVVLLAGSTLKGRE 192
Cdd:COG2223 366 LVFAVLAlVALVLTLLLYRRPRRAA 390
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
18-184 |
4.47e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 45.70 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLD-STIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVG-----EVRLFLWstGLFVLA 91
Cdd:cd17327 10 LCILYFLQYLDkSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPpskwlSVFIVLW--GLLTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SWLCgmsNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPIL--GGYISDNYH---- 165
Cdd:cd17327 88 TAAV---KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLayGVFKILGVGglag 164
|
170
....*....|....*....
gi 488137538 166 WGWIFFInipIGLVVVLLA 184
Cdd:cd17327 165 WRWLFII---EGLITIIIG 180
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
5-183 |
4.81e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.65 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 5 PLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWS 84
Cdd:cd17365 163 PLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 85 TGLFVLAswLCGMSNSLGMLIFFRVIqGLVAGPLIPLSQSLLL----NNYPPAKRSMALAlWSMTI-VVAPIFGPILGGY 159
Cdd:cd17365 243 FALGAVS--LALLGVSPASLVLLYVL-VFLAGACVNGAQVGLYalaaRFYPTEVRATGVG-WALGVgRLGAILGPLLGGL 318
|
170 180
....*....|....*....|....*
gi 488137538 160 -ISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:cd17365 319 lLAAGLGPESVFLALAIPAALGALA 343
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-184 |
1.04e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 18 LSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLA-SWLCG 96
Cdd:cd17355 215 LALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGlALLLL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 97 MSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYH-WGWIFFINIP 175
Cdd:cd17355 295 LPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVA 374
|
....*....
gi 488137538 176 IGLVVVLLA 184
Cdd:cd17355 375 LGLIAALLV 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
273-419 |
1.42e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 273 CLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRAY 352
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488137538 353 TFepgmDFGASAWPQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTL 419
Cdd:pfam07690 82 AS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-184 |
2.09e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.57 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQVLDSTIANVAIPTIAGD-LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLA 91
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 92 SW-LCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYH-WGWI 169
Cdd:cd06174 283 GLaLLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGA 362
|
170
....*....|....*
gi 488137538 170 FFINIPIGLVVVLLA 184
Cdd:cd06174 363 FLVLAVLLLLAAILL 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-160 |
2.12e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.50 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 2 AQKPLEGAPLAWMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLF 81
Cdd:TIGR00895 239 VFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 82 LWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALAlWSMTI--VVApIFGPILGGY 159
Cdd:TIGR00895 319 LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVG-WAIGIgrLGA-IIGPILAGY 396
|
.
gi 488137538 160 I 160
Cdd:TIGR00895 397 L 397
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
13-347 |
3.02e-04 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 43.00 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 13 WMTVALSLATFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS 92
Cdd:cd17336 3 VFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGC 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 93 WLCGMSNslgMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGyisdnyhwgwiFFI 172
Cdd:cd17336 83 FLLALPH---FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS-----------FLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 173 NIPIGLVVVLLAGSTlkgretkTEIRPIDTIGLVLLVVGIgalqimldqgkeldwfnsteiivLTVVAVVAITFLivwel 252
Cdd:cd17336 149 RIYVDFSRVPLGITP-------DDPRWIGAWWLGFLILGI-----------------------LLLIVSIPLFFF----- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 253 tddhPVIdlslfksrnFTIGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIG-----RFa 327
Cdd:cd17336 194 ----PPI---------FILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGgliikKF- 259
|
330 340
....*....|....*....|
gi 488137538 328 hRIDMRQLVTFSFIMYAVCF 347
Cdd:cd17336 260 -KLTARGLAKFVLILSLLSV 278
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
11-182 |
3.69e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 42.77 E-value: 3.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 11 LAWMTVALSLATF--MQVLdstianvaiPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLF 88
Cdd:PRK10091 8 LALGTFGLGMAEFgiMGVL---------TELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 89 VLASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGW 168
Cdd:PRK10091 79 VIGNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRY 158
|
170
....*....|....
gi 488137538 169 IFFINIPIGLVVVL 182
Cdd:PRK10091 159 TFLLIAVFNIAVLA 172
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
36-165 |
5.32e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 36 IPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLA--KRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGL 113
Cdd:cd17352 206 LPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGF 285
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488137538 114 VAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYH 165
Cdd:cd17352 286 CSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
269-419 |
6.26e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 269 FTIGCLCLSLAYMLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFY 348
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488137538 349 WRAYTFEPGMDFGAsawpQFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTL 419
Cdd:COG2271 91 LFGFATSFWQLLLL----RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
15-189 |
9.21e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.49 E-value: 9.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 15 TVALSLA-TFMQVLDSTIANVAIPTIAGDLGSSNSQGTWVitsFGVANAISIP---VTGWLAKRVGEVRLFLWSTGLFVL 90
Cdd:PRK11551 16 TIGLCFLvALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWA---FSAGILGLLPgalLGGRLADRIGRKRILIVSVALFGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 91 ASWLCGMSNSLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIF 170
Cdd:PRK11551 93 FSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
170
....*....|....*....
gi 488137538 171 FINIPIGLVVVLLAGSTLK 189
Cdd:PRK11551 173 YVGGVGPLLLVPLLMRWLP 191
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-180 |
9.43e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 9.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 43 LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLAS-WLCGMSNSLGMLIFFRVIQGLVAGPLIPL 121
Cdd:cd17477 218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAAlLLPLVPGLPLALLVLLFLWGGAAGPLYTL 297
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488137538 122 SQSLLLNNYPPAKR----SMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVV 180
Cdd:cd17477 298 ALALAGDRLPGDELvaanAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-416 |
1.26e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 42 DLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIF-FRVIQGLVAGpLIP 120
Cdd:cd17352 32 EFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLG-LIY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 121 LSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFInipiglvvvlLAGstlkgretkteirpi 200
Cdd:cd17352 111 SPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI----------LGG--------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 201 dtigLVLLVVGIGALqimldqgkeldwfnsteiivltvvavvaitflivweltddhpvidLSLFKSRNFTIGCLCLSLAY 280
Cdd:cd17352 166 ----LCLNLCVCGLL---------------------------------------------LRLLKDPTFVLLALGVSFAM 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 281 MLYFGAIVLLPQLLQEvYGYTATWAGLASAPVGILPVLLSPLIG----RFAHRIDMRQLVTFSFIMYAVCFYWRAYTFEP 356
Cdd:cd17352 197 LGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGlladKPRIGRLYLYIFTLLILGLSLLAFPLATTYVG 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 357 GMDFGAsawpqfFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSIT 416
Cdd:cd17352 276 LIVFSV------LFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA 329
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
271-419 |
1.54e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 271 IGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWR 350
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488137538 351 AYTFEPGMDFGASawpqFFQGFAIACFFMPLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITTTL 419
Cdd:COG2814 93 ALAPSLWLLLAAR----FLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
63-183 |
2.00e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.50 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 63 ISIPVtGWLAKRVGevrlFLWSTGL-----FVLASWLCGMSNSLGMLIFF-RVIQGLVAGPLIPLSQSLLLNNYPPAKRS 136
Cdd:TIGR00894 92 IQIPV-GYLAGKYV----FKWSIGIgmflsSVISIVIPWAAGGGIALVVFcRVIQGLAQGSVSPATHKIIVKWAPPKERS 166
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 488137538 137 MALAL-WSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:TIGR00894 167 RLLGMsTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLL 214
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
12-417 |
2.15e-03 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 40.40 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 12 AWMTVAlSLATFMQVLDSTIANVAIPTIAGDL--------GSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLW 83
Cdd:TIGR00879 28 LLSLIA-AIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 84 STGLFVLASWLCGMSN---SLGMLIFFRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILG-GY 159
Cdd:TIGR00879 107 IALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGsGK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 160 ISDNYHWGWiffiNIPIGLVVVLLAgstlkgretkteirpidtIGLVLLVVGIGALQIMLDQGKE------LDWFNSTEI 233
Cdd:TIGR00879 187 VSLNNTLGW----RIPLGLQLIPAG------------------LLFLGLFFLPESPRWLVGKGRVeearksLARLRGTSG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 234 IVLTVVAVVAITFLIVWELTDDHPVIDLSLFKS------RNFTIGCLCLSL-----AYMLYFGaivllPQLLQEVyGYTA 302
Cdd:TIGR00879 245 EDKELLDELELIDIKRSIEKRSVQPSWGSLFSStrrirrRLFLGVVLQWFQqftgiNAIMYYS-----PTIFENA-GVST 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 303 TWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWRA---YTFEPGMDFGASAWPQFFQGFAIACFFM 379
Cdd:TIGR00879 319 DHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGilgASFVTGSSKSSGNVAIVFILLFIAFFAM 398
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 488137538 380 ---PLTTITLSGLPPERMAAASSLSNFMRTLAGSIGTSITT 417
Cdd:TIGR00879 399 gwgPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLF 439
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
271-416 |
2.24e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 271 IGCLCLSLAYMLYFGAIVLLPQLLQEVYGYTATWAGLASAPVGILPVLLSPLIGRFAHRIDMRQLVTFSFIMYAVCFYWR 350
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488137538 351 AYTFEPGMDFGASAwpqfFQGFAIACFFMPLTTItLSGLPPERMAAASSLSNFMRTLAGSIGTSIT 416
Cdd:COG2807 101 SLAPSVALLLAGTA----LIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLT 161
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-184 |
2.50e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 2 AQKPLEGAPLAWMTVALSLATFMQVLDSTIA---NVAIPTIAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEV 78
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLLIIVFLRSWVLsslTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 79 RLFLWSTGLFVLASWLCGMSNSLGMLIFFrviqgLVAGPLIPLSQSLLL---NNYPPAKRSMALAL-WSMTIVVAPIFGP 154
Cdd:cd17478 261 RVIIASLLLAAPFLLLFLLTPGIWSYILL-----VLAGFLLFASFPVTVvlaQELLPGNVGLASGLmMGLSFGLGGIGAP 335
|
170 180 190
....*....|....*....|....*....|
gi 488137538 155 ILgGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd17478 336 VL-GALADAFGLESVLLILALLPLLGALLA 364
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
39-192 |
2.86e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 40.30 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 39 IAGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPL 118
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488137538 119 IPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLAGSTLKGRE 192
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKE 197
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
40-183 |
3.17e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 40 AGDLGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGPLI 119
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488137538 120 PLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLL 183
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
30-182 |
3.27e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 30 TIANVAIPTIAGDLGSSNSQgtwVITSFGVANAISIP---VTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIF 106
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTE---LIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWI 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 107 FRVIQGLVAGPLIPLSQSLLLNNYPPAKRSMALALWSMTIVVAPIFGPILGG---YISDNYHWGW----IFFInipIGLV 179
Cdd:COG2270 333 LGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGlvtQLTGSQRLGIlsliVFFV---IGLV 409
|
...
gi 488137538 180 VVL 182
Cdd:COG2270 410 LLL 412
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|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
53-184 |
3.99e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 53 VITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWLCGMSNSLGMLIFFRVIQGLVAGpLIPLSQSLLLNNYPP 132
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488137538 133 AKRSMALALWSMTIVVAPIFGPILGGYISDNYHWGWIFFINIPIGLVVVLLA 184
Cdd:cd17391 120 EKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLT 171
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|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
43-172 |
4.11e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488137538 43 LGSSNSQGTWVITSFGVANAISIPVTGWLAKRVGEVRLFLWSTGLFVLASWL---CGMSNSLGMLIFFRVIQGLVAGPLI 119
Cdd:cd17321 199 LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLlalLGADSSVWLLLPGLVLLGLGLGLFA 278
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 488137538 120 PLSQSLLLNNYPPAKRSMALALWSMT-----IVVAPIFGPILGGYISDNYHWGWIFFI 172
Cdd:cd17321 279 TPLTNAALSSVPKEKAGAASGILNTArqlggALGVALLGALLTAGLSANLGDSGVAAL 336
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