|
Name |
Accession |
Description |
Interval |
E-value |
| RosB |
COG4651 |
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ... |
3-557 |
5.58e-160 |
|
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain] Cd Length: 564 Bit Score: 468.30 E-value: 5.58e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 3 HDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLL 82
Cdd:COG4651 2 HETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 83 LVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLVmv 162
Cdd:COG4651 82 AVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLA-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 163 lvlvllpATAVLLGGKAPAGADGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAY 242
Cdd:COG4651 160 -------VVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 243 GSyAIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTLAA 322
Cdd:COG4651 233 LA-ALFGLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 323 MALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEPVQRWIRERSHL 402
Cdd:COG4651 312 FLIVLALGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 403 ARLLERSGDPLAMLPDEVDQAYLRdqvvivgygGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATEPSV 482
Cdd:COG4651 392 AARLERDRPEESDLVVHVVVVGGG---------GGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLE 462
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488043754 483 LIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEAAVIRDENIGEVFYAKEEMAKNMSHHIL 557
Cdd:COG4651 463 LLAALLAAAAIAVVAIPAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVEEEEEAAEAALLLL 537
|
|
| PRK10669 |
PRK10669 |
putative cation:proton antiport protein; Provisional |
1-552 |
8.75e-149 |
|
putative cation:proton antiport protein; Provisional
Pssm-ID: 182633 [Multi-domain] Cd Length: 558 Bit Score: 439.53 E-value: 8.75e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 1 MPHDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKD 80
Cdd:PRK10669 1 MHHATPLITTIVGGLVLAFILGMLANRLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 81 LLLVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLV 160
Cdd:PRK10669 81 LMAVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 161 MVLVLVLLPATAVLLGgKAPAGAdGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSI 240
Cdd:PRK10669 161 MVLTLVLLPAVAGMME-QGDVGF-ATLAVDLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 241 AYGSYAIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTL 320
Cdd:PRK10669 239 AFGAVELFDVSFALGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLAVLATLAIIVFGKSL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 321 AAMALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEpvqRWIRERS 400
Cdd:PRK10669 319 AAFFLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLFTLLE---RYLAKTE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 401 HLA-RLLERSGDPLAMLPdeVDqayLRDQVVIVGYGGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATE 479
Cdd:PRK10669 396 TLEeQTLEEAIEEEKQIP--VD---ICNHALLVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERGIRAVLGNAAN 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488043754 480 PSVLIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEAAVIRDENIGEVFYAKEEMAKNM 552
Cdd:PRK10669 471 EEIMQLAHLDCARWLLLTIPNGYEAGEIVASAREKRPDIEIIARAHYDDEVAYITERGANQVVMGEREIARTM 543
|
|
| 2a37 |
TIGR00932 |
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ... |
18-296 |
6.83e-52 |
|
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain] Cd Length: 273 Bit Score: 178.61 E-value: 6.83e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 18 ALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIALPGAILQIA 97
Cdd:TIGR00932 4 AVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 98 VA-TLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLVMVLVLVLLPAtavLLG 176
Cdd:TIGR00932 84 VPgVLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPL---LAT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 177 GKAPAGADgniwltLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAYGSyAIFGVSMALGA 256
Cdd:TIGR00932 161 SASTEHVA------LALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFA-DLLGLSMALGA 233
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 488043754 257 FFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFD 296
Cdd:TIGR00932 234 FLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSVD 273
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
11-389 |
1.13e-41 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 154.34 E-value: 1.13e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 11 LAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPG-IEADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIAL 89
Cdd:pfam00999 1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGlISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 90 PGAILQIAVATLL-GIGVSMLW-GWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDlvmvlvlvl 167
Cdd:pfam00999 81 LLALLGVLIPFVLiGLLLYLLGlGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLND--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 168 lpATAVLLGGKAPAGADGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVAR--LGSRELFTLTVVAAAVSIAYGSy 245
Cdd:pfam00999 152 --GVAVVLLAVLLALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRftDDDRELEVLLVLLLALLAALLA- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 246 AIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSI-LFFVSVGMLFDPHILVES-PLHILAVIAIIMVGKTLAAM 323
Cdd:pfam00999 229 EALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNpLFFVLVGLSLDLSSLLLSvWILVLLALVAILLGRFLGVF 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488043754 324 ALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAI 389
Cdd:pfam00999 309 LLLRLLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPL 374
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RosB |
COG4651 |
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ... |
3-557 |
5.58e-160 |
|
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];
Pssm-ID: 443689 [Multi-domain] Cd Length: 564 Bit Score: 468.30 E-value: 5.58e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 3 HDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLL 82
Cdd:COG4651 2 HETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 83 LVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLVmv 162
Cdd:COG4651 82 AVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQDLA-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 163 lvlvllpATAVLLGGKAPAGADGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAY 242
Cdd:COG4651 160 -------VVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 243 GSyAIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTLAA 322
Cdd:COG4651 233 LA-ALFGLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 323 MALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEPVQRWIRERSHL 402
Cdd:COG4651 312 FLIVLALGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 403 ARLLERSGDPLAMLPDEVDQAYLRdqvvivgygGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATEPSV 482
Cdd:COG4651 392 AARLERDRPEESDLVVHVVVVGGG---------GGGGGLALRLLLRGIVVVVVVDNVEEVVRARRRGGIAGGGGAAADLE 462
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488043754 483 LIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEAAVIRDENIGEVFYAKEEMAKNMSHHIL 557
Cdd:COG4651 463 LLAALLAAAAIAVVAIPAAAAALLLIAAARRALPLLIIIARAARRAEEEELLLAGAVEVVVEEEEEAAEAALLLL 537
|
|
| PRK10669 |
PRK10669 |
putative cation:proton antiport protein; Provisional |
1-552 |
8.75e-149 |
|
putative cation:proton antiport protein; Provisional
Pssm-ID: 182633 [Multi-domain] Cd Length: 558 Bit Score: 439.53 E-value: 8.75e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 1 MPHDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKD 80
Cdd:PRK10669 1 MHHATPLITTIVGGLVLAFILGMLANRLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 81 LLLVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLV 160
Cdd:PRK10669 81 LMAVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 161 MVLVLVLLPATAVLLGgKAPAGAdGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSI 240
Cdd:PRK10669 161 MVLTLVLLPAVAGMME-QGDVGF-ATLAVDLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 241 AYGSYAIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTL 320
Cdd:PRK10669 239 AFGAVELFDVSFALGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLAVLATLAIIVFGKSL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 321 AAMALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEpvqRWIRERS 400
Cdd:PRK10669 319 AAFFLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNPVLFTLLE---RYLAKTE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 401 HLA-RLLERSGDPLAMLPdeVDqayLRDQVVIVGYGGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATE 479
Cdd:PRK10669 396 TLEeQTLEEAIEEEKQIP--VD---ICNHALLVGYGRVGSLLGEKLLAAGIPLVVIETSRTRVDELRERGIRAVLGNAAN 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488043754 480 PSVLIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEAAVIRDENIGEVFYAKEEMAKNM 552
Cdd:PRK10669 471 EEIMQLAHLDCARWLLLTIPNGYEAGEIVASAREKRPDIEIIARAHYDDEVAYITERGANQVVMGEREIARTM 543
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
3-397 |
1.16e-71 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 234.66 E-value: 1.16e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 3 HDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLL 82
Cdd:COG0475 1 LLASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 83 LVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGwllvedLVMV 162
Cdd:COG0475 81 KMGRRALGIGLLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILG------VALF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 163 LVLVLLPATAVLLGGKAPAGADGNIWLtlgiTLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAY 242
Cdd:COG0475 155 DDIAAILLLALVPALAGGGSVAGSLLL----ALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLAAA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 243 GSYAIfGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTLAA 322
Cdd:COG0475 231 LAELL-GLSAALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAIVGKLLGA 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488043754 323 MALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEPVQRWIR 397
Cdd:COG0475 310 YLAARLFGLSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRLAERAK 384
|
|
| 2a37 |
TIGR00932 |
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ... |
18-296 |
6.83e-52 |
|
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273348 [Multi-domain] Cd Length: 273 Bit Score: 178.61 E-value: 6.83e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 18 ALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIALPGAILQIA 97
Cdd:TIGR00932 4 AVLAVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGVGVLQVL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 98 VA-TLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLVMVLVLVLLPAtavLLG 176
Cdd:TIGR00932 84 VPgVLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPL---LAT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 177 GKAPAGADgniwltLGITLLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAYGSyAIFGVSMALGA 256
Cdd:TIGR00932 161 SASTEHVA------LALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFA-DLLGLSMALGA 233
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 488043754 257 FFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFD 296
Cdd:TIGR00932 234 FLAGVVLSESEYRHKLESDLEPIGGVLLPLFFISVGMSVD 273
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
11-389 |
1.13e-41 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 154.34 E-value: 1.13e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 11 LAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPG-IEADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIAL 89
Cdd:pfam00999 1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGlISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 90 PGAILQIAVATLL-GIGVSMLW-GWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDlvmvlvlvl 167
Cdd:pfam00999 81 LLALLGVLIPFVLiGLLLYLLGlGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLND--------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 168 lpATAVLLGGKAPAGADGNIWLTLGITLLKVIGFIAFMLIVGKRVVPIIMQFVAR--LGSRELFTLTVVAAAVSIAYGSy 245
Cdd:pfam00999 152 --GVAVVLLAVLLALAQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRftDDDRELEVLLVLLLALLAALLA- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 246 AIFGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSI-LFFVSVGMLFDPHILVES-PLHILAVIAIIMVGKTLAAM 323
Cdd:pfam00999 229 EALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNpLFFVLVGLSLDLSSLLLSvWILVLLALVAILLGRFLGVF 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488043754 324 ALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAI 389
Cdd:pfam00999 309 LLLRLLGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPL 374
|
|
| PRK03659 |
PRK03659 |
glutathione-regulated potassium-efflux system protein KefB; Provisional |
24-530 |
1.19e-40 |
|
glutathione-regulated potassium-efflux system protein KefB; Provisional
Pssm-ID: 179625 [Multi-domain] Cd Length: 601 Bit Score: 155.57 E-value: 1.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 24 IAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIALPGAILQIAVATLLG 103
Cdd:PRK03659 23 LAQRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAAVL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 104 IGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGK----------IAVgwllvedlvmvlvlvlLPATAV 173
Cdd:PRK03659 103 AGLLMLTDFSWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQlgfsvllfqdLAV----------------IPALAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 174 --LLGGKAPAGADgniWLTLGitlLKVIGFIAfMLIVGKRVVPIIMQFVARLGSRELFTltvvAAAVSIAYGSyAIF--- 248
Cdd:PRK03659 167 vpLLAGSADEHFD---WMKIG---MKVLAFAG-MLIGGRYLLRPLFRFIAASGVREVFT----AAALLLVLGS-ALFmda 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 249 -GVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTLAAMALVL 327
Cdd:PRK03659 235 lGLSMALGTFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGVLYTHLLWVLISVVVLVAVKGLVLYLLAR 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 328 FFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEpvqRWirershLARLLE 407
Cdd:PRK03659 315 LYGLRSSERMQFAGVLSQGGEFAFVLFSAASSQRLLQGDQMALLLVVVTLSMMTTPLLMKLID---KW------LARRLN 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 408 rSGDPLAMLPDEVDQaylRDQVVIVGYGGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATEPSVLIQAH 487
Cdd:PRK03659 386 -GPEEEDEKPWVEDD---KPQVIIVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQLELLRAAG 461
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 488043754 488 IMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEA 530
Cdd:PRK03659 462 AEKAEAIVITCNEPEDTMKIVELCQQHFPHLHILARARGRVEA 504
|
|
| PRK03562 |
PRK03562 |
glutathione-regulated potassium-efflux system protein KefC; Provisional |
3-520 |
3.92e-40 |
|
glutathione-regulated potassium-efflux system protein KefC; Provisional
Pssm-ID: 235131 [Multi-domain] Cd Length: 621 Bit Score: 154.38 E-value: 3.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 3 HDVDLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPGIEADIHLANQLAELGVMFLMFGVGMHFSLKDLL 82
Cdd:PRK03562 2 MDSHTLIQALIYLGAAVLIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 83 LVRRIALPGAILQIAVATLLGIGVSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKIAVGWLLVEDLVMV 162
Cdd:PRK03562 82 KLRRSIFGGGALQMVACGGLLGLFCMLLGLRWQVALLIGLGLALSSTAIAMQAMNERNLMVTQMGRSAFAILLFQDIAAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 163 LVLVLLPatavLLGGKAPAGADGNIWLTLgitlLKVIGFIAFMLIVGKRVVPIIMQFVARLGSRELFTLTVVAAAVSIAY 242
Cdd:PRK03562 162 PLVAMIP----LLAASGASTTLGAFALSA----LKVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVFGFGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 243 GSYAIfGVSMALGAFFAGMVVKESDFSHRAEEETLPLREIFSILFFVSVGMLFDPHILVESPLHILAVIAIIMVGKTLAA 322
Cdd:PRK03562 234 LMEEV-GLSMALGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLLGFLAIKIAML 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 323 MALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLE-AQNLILAGALfSITLNSFIFSAIEpvqRWIRERSH 401
Cdd:PRK03562 313 WLLARPLGVPRKQRRWFAVLLGQGGEFAFVVFGAAQMANVLEPEwAKLLTLAVAL-SMAATPLLLVLLD---RLEQSRTE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 402 LARllersgdplamLPDEVDQaylrdQVVIVGYGGVGRR---ITENLINENIKVVIAEENREIVEKLRNANIAAVSGVAT 478
Cdd:PRK03562 389 EAR-----------EADEIDE-----QQPRVIIAGFGRFgqiVGRLLLSSGVKMTVLDHDPDHIETLRKFGMKVFYGDAT 452
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 488043754 479 EPSVLIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQV 520
Cdd:PRK03562 453 RMDLLESAGAAKAEVLINAIDDPQTSLQLVELVKEHFPHLQI 494
|
|
| Kch |
COG1226 |
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism]; |
292-560 |
9.89e-20 |
|
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
Pssm-ID: 440839 [Multi-domain] Cd Length: 279 Bit Score: 89.40 E-value: 9.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 292 GMLFDPHILVESPLHILAVIAIIMVGKTLAAMALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLI 371
Cdd:COG1226 1 LGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLAALALAALLLLLLLAGGGGFFLLLLLAAAALLLLLLLAAALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 372 LAGALFSITLNSFIFSAIepvqrwirersHLARLLERSGDPLAMLPDEVDQAYLRDQVVIVGYGGVGRRITENLINENIK 451
Cdd:COG1226 81 LLLVLLLLLLLLLLLLLL-----------ALLLLLLALAAREEEAEAAEDAIDLEGHVIIAGFGRVGQIVARLLRAEGIP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 452 VVIAEENREIVEKLRNANIAAVSGVATEPSVLIQAHIMHARLLVISPMDILDIHRIVAIAKQLNPQIQVLICAESKEEAA 531
Cdd:COG1226 150 FVVIDLDPERVEELRRFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRIVELARELNPDLKIIARARDREHAE 229
|
250 260
....*....|....*....|....*....
gi 488043754 532 VIRDENIGEVFYAKEEMAKNMSHHILSQI 560
Cdd:COG1226 230 ELRQAGADEVVRETFESALQLARHALEAL 258
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
6-316 |
5.06e-14 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 74.62 E-value: 5.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 6 DLIILLAVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTP-GIEADIHLANQLAELGVMFLMFGVGMHFSLKDLL-- 82
Cdd:COG0025 2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGPGLGlELDPELGDLEPLLELFLPPLLFEAALNLDLRELRrn 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 83 --LVRRIALPGAILQIAVATLLGigvSMLWGWSFGSALVFGLSLSCASTVVLLKALGDRGLLDSVNGKI--------AVG 152
Cdd:COG0025 82 grPILRLAVVGVLLTTLAVALAA---HWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTILegesllndATA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 153 wllvedlvmvlvlvllpATAVLLGGKAPAGADGNIWLTLGITLLKVIGFIAFMLIVGKrvvpIIMQFVARLGSRELFTLT 232
Cdd:COG0025 159 -----------------LVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGW----LLGRLLRRLPDPLLEILL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 233 VVAaavsIAYGSYAI---FGVSMALGAFFAGMVVKESDFSHRAEEETLPLRE-------IFSILFFVSVGMLFDPHILVE 302
Cdd:COG0025 218 TLA----LPFLAYLLaeaLHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEfwetlefLLNSLLFVLLGAQLPLILLGA 293
|
330
....*....|....
gi 488043754 303 SPLHILAVIAIIMV 316
Cdd:COG0025 294 LGLGGILLVLLALL 307
|
|
| TrkA_N |
pfam02254 |
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ... |
439-543 |
3.59e-09 |
|
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.
Pssm-ID: 426679 [Multi-domain] Cd Length: 115 Bit Score: 54.45 E-value: 3.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 439 RRITENLINENIKVVIaEENREIVEKLRNANIAAVSGVATEPSVLIQAHIMHARLLVI-SPMDILDIhRIVAIAKQLNPQ 517
Cdd:pfam02254 11 RSLAEELSEGGDVVVI-DKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAaTGDDEANI-LIVLLARELNPD 88
|
90 100
....*....|....*....|....*.
gi 488043754 518 IQVLICAESKEEAAVIRDENIGEVFY 543
Cdd:pfam02254 89 KKIIARANDPEHAELLRRLGADHVIS 114
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
324-558 |
2.32e-08 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 55.84 E-value: 2.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 324 ALVLFFRYPINTALTVGASLAQIGEFSFILATLGVSLGLLSLEAQNLILAGALFSITLNSFIFSAIEPVQRWIRERSHLA 403
Cdd:COG0569 2 LILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 404 RLLERSGDPLAMLPDEVdqaylrdqvVIVGYGGVGRRITENLINENIKVVIAEENREIVEKLRNANIAAVSGVATEPSVL 483
Cdd:COG0569 82 LRRRRMERGIKKLKMHV---------IIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVL 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488043754 484 IQAHIMHARLLVI-SPMDILDIhRIVAIAKQLNPqIQVLICAESKEEAAVIRDENIGEVFYAKEEMAKNMSHHILS 558
Cdd:COG0569 153 EEAGIEDADAVIAaTGDDEANI-LACLLAKELGV-PRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLR 226
|
|
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-334 |
7.49e-06 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 48.66 E-value: 7.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 3 HDVDLIILL-AVGFGVALIFGYIAARLRLPPLIGYLIAGIIISPNTPG-IE-ADIHLANQLAELGVMFLMFGVGMHFSLK 79
Cdd:PRK05326 2 DTINSLLLIgALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGgIQfDNYPLAYLVGNLALAVILFDGGLRTRWS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 80 DlllVRRIALPGAILQ----IAVATLLGIGVSMLWGWSFGSALVFGLSLS---CASTVVLLKALGD------RGLLD--- 143
Cdd:PRK05326 82 S---FRPALGPALSLAtlgvLITAGLTGLFAHWLLGLDWLEGLLLGAIVGstdAAAVFSLLRGKGLnlkervASTLEies 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 144 SVNGKIAVgwllvedlvmvlvlvllPATAVLLGgkAPAGADGNIWLTLGITLLKVIGF-IAFMLIVGKRVVPIIMQFvaR 222
Cdd:PRK05326 159 GSNDPMAV-----------------FLTITLIE--LITGGETGLSWGFLLLFLQQFGLgALIGLLGGWLLVQLLNRI--A 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 223 LGSRELFTLTVVAAAVsIAYGSYAIFGVSMALGAFFAGMVVKESDFSHRAEeeTLPLRE----IFSILFFVSVGMLFDPH 298
Cdd:PRK05326 218 LPAEGLYPILVLAGAL-LIFALTAALGGSGFLAVYLAGLVLGNRPIRHRHS--ILRFFDglawLAQIGMFLVLGLLVTPS 294
|
330 340 350
....*....|....*....|....*....|....*..
gi 488043754 299 ILVESPLHILAV-IAIIMVGKTLAAMALVLFFRYPIN 334
Cdd:PRK05326 295 RLLDIALPALLLaLFLILVARPLAVFLSLLPFRFNLR 331
|
|
| AbrB |
COG3180 |
Uncharacterized membrane protein AbrB, regulator of aidB expression [General function ... |
11-118 |
9.93e-05 |
|
Uncharacterized membrane protein AbrB, regulator of aidB expression [General function prediction only];
Pssm-ID: 442413 [Multi-domain] Cd Length: 352 Bit Score: 44.80 E-value: 9.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 11 LAVGFGVALIFGYIAARLRLP--PLIGYLIAGIIISPNTPgieADIHLANQLAELGVMFLMFGVGMHFSLKDLLLVRRIA 88
Cdd:COG3180 189 LLLLLALALAGGLLGRRLRLPagALLGPLLLSAALHLTGL---VTAALPPWLLAAAQVLIGWSIGLRFTRETLRELLRLL 265
|
90 100 110
....*....|....*....|....*....|...
gi 488043754 89 LPGA---ILQIAVATLLGIGVSMLWGWSFGSAL 118
Cdd:COG3180 266 PAALlstLLLIALCALFAWLLALLTGLDLLTAL 298
|
|
| AbrB |
pfam05145 |
Transition state regulatory protein AbrB; Bacillus subtilis respond to a multitude of ... |
6-118 |
1.38e-03 |
|
Transition state regulatory protein AbrB; Bacillus subtilis respond to a multitude of environmental stimuli by using transcription factors called transition state regulators (TSRs). They play an essential role in cell survival by regulating spore formation, competence, and biofilm development. AbrB is one of the most known TSRs, acting as a pleotropic regulator for over 60 different genes where it directly binds to their promoter or regulatory regions. Many other genes are indirectly controlled by AbrB since it is a regulator of other regulatory proteins, including ScoC, Abh, SinR and SigH. Hence, AbrB is considered a global regulatory protein controlling processes such as Bacillus subtilis growth and cell division as well as production of extracellular degradative enzymes, nitrogen utilization and amino acid metabolism, motility, synthesis of antibiotics and their resistant determinants, development of competence, transport systems, oxidative stress response, phosphate metabolism, cell surface components and sporulation. AbrB is a tetramer consisting of identical 94 residue monomers. Its DNA-binding function resides solely in the N-terminal domain (AbrBN) of 53 residues. Although it does not recognize a well-defined DNA base-pairing sequence, instead, it appears to target a very weak pseudo consensus nucleotide sequence, TGGNA-5bp-TGGNA, which allows it to be rather promiscuous in binding. The N-terminal domains of very similar sequences are present in two more Bacillus subtilis proteins, Abh and SpoVT. Mutagenesis studies suggest that the role of the C-terminal domain is in forming multimers.
Pssm-ID: 428334 [Multi-domain] Cd Length: 312 Bit Score: 40.99 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043754 6 DLIILLAVGFGVALIFGYIAARLRLP--PLIGYLIAGIIIspNTPGIEaDIHLANQLAELGVMFLMFGVGMHFSLKDLLL 83
Cdd:pfam05145 152 SWSWFLALLLALALLGALLGRRLRLPaaALLGPLLVGAAL--HLTGLL-TIALPPWLLALAQLLIGWSIGLRFTRETLRE 228
|
90 100 110
....*....|....*....|....*....|....*....
gi 488043754 84 VRRiALPGAILQ----IAVATLLGIGVSMLWGWSFGSAL 118
Cdd:pfam05145 229 LAR-ALPAALGStlllIALCAGLAWLLAWLTGVDFLTAY 266
|
|
| |
