|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
7-423 |
1.44e-82 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 258.74 E-value: 1.44e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 7 VLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGD---PVLDQFADWTRILLEASSGDRSLFVaLFGGIVASLYSILQFIFA 83
Cdd:cd17389 3 IVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSglySLQISSVDWFRDAIGAPDERRYNSV-LFGGLIGSLFSLLQFLSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 84 PIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGV 163
Cdd:cd17389 82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 164 GLGFIAGPPTGGLFAKINLdflklvfpDLTFTVFPASALAATIIALINLLMILFWFRETFDQKdllekkkihpilgvfts 243
Cdd:cd17389 162 SLGFIIGPMIGAYFASFTR--------SLGEVFFSMPALFALVLALADLLFIFFFLPETLPSN----------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 244 knkeVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSgKVDETKLIRIGTFSL 323
Cdd:cd17389 217 ----LRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIK-PGKEKKAVLQGLILL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 324 LVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAI 403
Cdd:cd17389 292 IPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEA 371
|
410 420
....*....|....*....|
gi 487908851 404 SFLTSGLVSFLFLLFIWKLK 423
Cdd:cd17389 372 CYTIGALLFLLPLLLLARLK 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-421 |
2.27e-55 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 187.02 E-value: 2.27e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 8 LFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPvldqfadwtrilleassgdrslfvaLFGGIVASLYSILQFIFAPIWG 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG-------------------------YYVGLLQSSYSLGQFLASPLWG 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 88 RISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLGF 167
Cdd:cd17330 56 RLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGF 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 168 IAGPPTGGLFAKINLDFLKLVFpdltftvfpasalaATIIALINLLMILFWFRetfdqkdllekkkihPILGVFtsknke 247
Cdd:cd17330 136 ILGPALGGFLSTPYGYALPFLV--------------AAALALLNLVLVLFFLP---------------PLRRLL------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 248 vvlysIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLLVGF 327
Cdd:cd17330 181 -----LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 328 FILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLT 407
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
|
410
....*....|....
gi 487908851 408 SGLVSFLFLLFIWK 421
Cdd:cd17330 336 AAGLLLIALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
7-397 |
7.94e-51 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 175.90 E-value: 7.94e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 7 VLFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDpvldqfadwtrilleassgdrslfVALFGGIVASLYSILQFIFAPIW 86
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFVGDSAD------------------------AATHYGVLLALYALMQFIFAPIL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 87 GRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLG 166
Cdd:cd17388 59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 167 FIAGPPTGGLFAKINldflklvfPDLTFtvfpasaLAATIIALINLLMILFWFRETF--DQKDLLEKKKIHPILGVFTSK 244
Cdd:cd17388 139 FIAGPALGGLLGEIS--------PRAPF-------LVAAGLNGLNFLLGLFVLPESLppERRRAFRWRRANPFGSLRWLT 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 245 NKEVVLYSIFYFVFVFAFSGFEFSI-NFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSL 323
Cdd:cd17388 204 GFPGLLGLLAVFFLIQLIGQVPATTwVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAAD 283
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487908851 324 LVGFFILYFVSNSYQLFISLTFLASGSaLLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYF 397
Cdd:cd17388 284 ALGFLLLAFATQGWMVFPILILLALGG-IAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFA 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-423 |
4.68e-41 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 149.65 E-value: 4.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 8 LFFTVFIDMMGFSVIFPIFPETLKIflsqsgdpvldqfadwtrilLEASSgdrslfvaLFGGIVASLYSILQFIFAPIWG 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES--------------------LGASV--------AQIGLIVAAYALAQLLFSPPAG 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 88 RISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM-ADITNEKDRAKGMGMIGAGVGLG 166
Cdd:cd17325 53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIGLG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 167 FIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPILGVFT-SKN 245
Cdd:cd17325 133 FLIGPLLGGLLA--------------DALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLlLRD 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 246 KEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVyIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLLV 325
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG-AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 326 GFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISF 405
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
410
....*....|....*...
gi 487908851 406 LTSGLVSFLFLLFIWKLK 423
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
8-424 |
8.82e-38 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 140.44 E-value: 8.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 8 LFFTVFIDMMGFSVIFPIFPETLKiflSQSGDPVLdqfadwtrilleassgdrslfvalfGGIVASLYSILQFIFAPIWG 87
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIR---SLGASPTV-------------------------IGLIGSVYGALQLFSSPLVG 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 88 RISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLGF 167
Cdd:cd17390 53 SWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGF 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 168 IAGPPTGGLFAKINLDFLKLvfpdltftvfpasALAATIIALINLLMILFWFREtfdqkdllekkkihpilgvftsknke 247
Cdd:cd17390 133 ILGPVVGGHLAETDGGFYYV-------------ALLCSAIFILNAGLVWFLLSK-------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 248 vvLYSIFYFVFVFAFSGFEFSINF--YLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLS-GKVDETKLIRIGTFSLL 324
Cdd:cd17390 174 --LWDLLLVRFLMGFSVLLFRSNFslYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKlYKNNEYLLLLHSFILLA 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 325 VGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYfSKGPAIS 404
Cdd:cd17390 252 LSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ-EFSVSGP 330
|
410 420
....*....|....*....|
gi 487908851 405 FLTSGLVSFLFLLFIWKLKQ 424
Cdd:cd17390 331 GLLGAVLALAAILLMLARQR 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-384 |
2.01e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.78 E-value: 2.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 3 KISFVLFFTVFIDMMGFSVIFPIFPEtlkIFLSQSGDPVLdqfadwtrilleassgdrslfvalfGGIVASLYSILQFIF 82
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPL---IAADLGASPAQ-------------------------AGLVVTAYLLGAALG 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 83 APIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADITNEKDRAKGMGMIGA 161
Cdd:COG2814 62 APLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 162 GVGLGFIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPILgvf 241
Cdd:COG2814 142 GLGLGPALGPLLGGLLA--------------DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL--- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 242 tsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQgGVFRRLSGKVDETKLIRIGTF 321
Cdd:COG2814 205 --RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLL 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487908851 322 SLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLG 384
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
73-420 |
4.86e-30 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 119.63 E-value: 4.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 73 SLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGnISVASAAMADITNEKDR 152
Cdd:cd17331 42 TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHA-MQAAQMVVTDLTDPGER 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 153 AKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFlklvfpdltftvfpASALAATIIALINLLMILFWFRETFDQKDLLEKK 232
Cdd:cd17331 121 AAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQ--------------AAALVAAVGSLLSIVLVILLIPSNTKSKREKEAK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 233 KIHPILGVFTSKNKEVVLY--SIFYFVFVFAFSGFEFSI-----NFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRR 305
Cdd:cd17331 187 ESASPPSVFNLKEILRLLRlpGVAFLLLVKLLSGLPIGMfqsmfSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGR 385
Cdd:cd17331 267 LTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVR 346
|
330 340 350
....*....|....*....|....*....|....*
gi 487908851 386 GMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17331 347 TVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-422 |
6.41e-25 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 105.39 E-value: 6.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 7 VLFFTVFIDMMGFSVIFPIFPETLKIFLSQSgdpvldqfadwtrilleassgdrslfvALFGGIVASLYSILQFIFAPIW 86
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLS---------------------------ASIVGLVLALSAVAGIVASLIG 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 87 GRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM-ADITNEKDRAKGMGMIGAGVGL 165
Cdd:cd17329 56 GRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMiADVTTPENRTRAFSLLYWAINL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 166 GFIAGPPTGGLFAKINLDFLklvfpdltftvfpasALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPILGVFTsKN 245
Cdd:cd17329 136 GVAIGPLLGGLLLLYSFRLL---------------FLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVL-RD 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 246 KEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQgGVFRRLSGKVDETKLIRIGTFSLLV 325
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 326 GFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISF 405
Cdd:cd17329 279 GFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
410
....*....|....*..
gi 487908851 406 LTSGLVSFLFLLFIWKL 422
Cdd:cd17329 359 LILAALGLIAAALLLGL 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-420 |
1.55e-23 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 101.13 E-value: 1.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADIT 147
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGiGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKinldflklvfpdltFTVFPASALAATIIALINLLMILFWFRETFDQKD 227
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------------HLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 LLEKKKIHPILgvftSKNKEVVLYSIFYFVFVFAFSgfefSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLS 307
Cdd:cd17489 180 EAEAGTRAFRR----LVEKKVLPPALILFLASIAYG----AISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 308 GKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGM 387
Cdd:cd17489 252 DRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL 331
|
330 340 350
....*....|....*....|....*....|...
gi 487908851 388 APFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17489 332 GGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-389 |
8.16e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 8.16e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 8 LFFTVFIDMMGFSVIFPIFPETLKIFLSQSGDPVldqfadwtrilleassgdrslfvalfgGIVASLYSILQFIFAPIWG 87
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI---------------------------GLLLTLFSLGYALAQPLAG 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 88 RISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLG 166
Cdd:pfam07690 54 RLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGlGAGALFPAALALIADWFPPEERGRALGLVSAGFGLG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 167 FIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPILGVFTS-KN 245
Cdd:pfam07690 134 AALGPLLGGLLA--------------SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAlLR 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 246 KEVVLYSIFYFVFVFAFSGFEFSINFYLSQFlNYKPIEIGFTFVyIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLLV 325
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLG-LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 326 GFFILYFVS---NSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAP 389
Cdd:pfam07690 278 AALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
69-422 |
4.51e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.87 E-value: 4.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMA-DIT 147
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIgDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLdflklvfpdltFTVFPASALAATIIalinLLMILFWFRETFDQKD 227
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISW-----------RYPFFLLAALIPVA----FLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 llEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQGGVFRRLS 307
Cdd:cd17474 182 --SSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 308 GKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGM 387
Cdd:cd17474 260 KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAV 339
|
330 340 350
....*....|....*....|....*....|....*
gi 487908851 388 APFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKL 422
Cdd:cd17474 340 GPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
67-421 |
3.10e-20 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 91.50 E-value: 3.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 67 FGGIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGSFLGYVIWLFSGSFSFFV-----LSRVITGTMGGNISVAS 140
Cdd:cd17326 37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPSNRkyvmlVARFLIGVGAGNVAVLR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 141 AAMADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDfLKLVFPDLTFTVFPASALAATIIALINLLMILFWFR 220
Cdd:cd17326 117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYP-GYVIGIKLRFNMYTAPAWLMAILGIINIILILFFFK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 221 EtfdqkdllekkkihpilgvftsknkevVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEI----GFTFVYIGMIIV 296
Cdd:cd17326 196 E---------------------------VVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAvlynGIILAVSGVLSV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 297 LIQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYfvsnSYQlFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGM 376
Cdd:cd17326 249 LVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTL----PWG-ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGV 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 487908851 377 FRSLASLGRGMAPFVFCLIYFSKGPAISFLTSG---LVSFLFLLFIWK 421
Cdd:cd17326 324 LTASGSLARTLGPIFVTAIYTHFGPRWTWIITLgllLLAIILLIVFYK 371
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
66-397 |
1.91e-17 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 83.62 E-value: 1.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 66 LFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSrvITGTMGGNISVASAAMAD 145
Cdd:cd17387 36 LMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAYVAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 146 ITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLKLvfpdltftvfpasaLAATIIALINLLMILFWFRETFDQ 225
Cdd:cd17387 114 ITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVV--------------LVATIVALLDICFILLAVPESLPE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 226 K-------DLLEKKKIHPILGVFTS-KNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVL 297
Cdd:cd17387 180 KmrpaswgAPISWEQADPFASLRKVgKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSIT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 298 IQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTfLASGSALLHPSLSTLVSLVSGKEEQGTNLGMF 377
Cdd:cd17387 260 AQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGA-VAAMSSITFPAISALVSRYADPDQQGAVQGMI 338
|
330 340
....*....|....*....|
gi 487908851 378 RSLASLGRGMAPFVFCLIYF 397
Cdd:cd17387 339 TGIRGLCNGLGPALFGFVFY 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
69-425 |
1.85e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.22 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADIT 147
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGlGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKiNLDFlklvfpdltFTVFPASALAATIIALINLLMIlfwfretfdqkd 227
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLA-AFGW---------RAAFLILGLPGLLLALLRFWLL------------ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 llekkkihpilgvftsknkevvlySIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGF--TFVYIGMIIVLIQGGvfrR 305
Cdd:COG2271 186 ------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLllSLPFLAGIVGSLLGG---W 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDE--TKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASL 383
Cdd:COG2271 239 LSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 487908851 384 GRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQP 425
Cdd:COG2271 319 GGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
9-420 |
2.50e-15 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 76.92 E-value: 2.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 9 FFTVFIDMMGFSVIFPIFPetlkIFLSQSGdpvldqfadwtrilleassGDRSLFVALFGGIVASLYSILQFIFAPIWGR 88
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLP----LYIEQLG-------------------VTSGGLVELWSGLAFSSTFLVSAIFSPIWGR 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 89 ISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLGFI 168
Cdd:cd17391 59 LADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 169 AGPPTGGLFAKINldflklvfpDLTFTVFPASalaatIIALINLLMILFWFRETFDQKdllEKKKIHPILGVFTSKNKEV 248
Cdd:cd17391 139 IGPLLGGFLADLF---------GIRNVFFITG-----GLLFLAFLLTLFFVKEDFKPV---EKKKMVSTKEVWNSVPNPS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 249 VLYSIFYFVFVFAFSGfeFSINFYLSQFLN-YKPIEIGFTFVYiGMII------VLIQGGVFRRLSGKVDETKLIRIGTF 321
Cdd:cd17391 202 LLISLFVTTFIIQLAN--QSIEPILTLYIRqLMGDASNLAFIS-GLVFsatgvsSLLSAPRLGKLGDRIGHHRILLGALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 322 SLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGP 401
Cdd:cd17391 279 ASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGY 358
|
410
....*....|....*....
gi 487908851 402 AISFLTSGLVSFLFLLFIW 420
Cdd:cd17391 359 RAVFVVTALLVLLNAIWSF 377
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
71-384 |
4.68e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 76.06 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 71 VASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNI-SVASAAMADITNE 149
Cdd:cd17321 36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAImPASLALIAATFPG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 150 KDRAKGMGMIGAGVGLGFIAGPPTGGLFakinldflklvfpdLTFTVFPASALAATIIALINLLMILFWFretfdqkdll 229
Cdd:cd17321 116 ERRGRALGLWGAVVGIGAALGPLLGGLL--------------LELFGWRWIFLINVPIGLVALLLARTFS---------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 230 ekkkihpiLGVFTSknkevvlysifyFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVyIGMIIVLIQGGVFRRLSGK 309
Cdd:cd17321 172 --------GAVLAA------------FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL-PLALAMLVAAPLAGRLADR 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487908851 310 VDETKLIRIGTFSLLVGFFILYFVSNS---YQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLG 384
Cdd:cd17321 231 FGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-222 |
5.40e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 71.53 E-value: 5.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM-ADIT 147
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALiADIY 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRET 222
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLA--------------QFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
69-420 |
7.31e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 7.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADIT 147
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGlAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDQKD 227
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG--------------QLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 lLEKKKIHPILGVFtsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTF--VYIGMIIVLIQGGvfrR 305
Cdd:cd17324 183 -GSLGLLSSLLLLL--RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLllFGVAGVVGSPLAG---R 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGkEEQGTNLGMFRSLASLGR 385
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|....*
gi 487908851 386 GMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17324 336 ALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
69-420 |
1.17e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.16 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM-ADIT 147
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALiADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLKLVFpdltftvFPASALAATIIALINLLMILFWFRETFDQKD 227
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF-------LIAAALALLAAILLLLVVPDPPESARAKNEE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 LLEKKKIHPILGVFtsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIG---FTFVYIGMIIVLIQGGVFR 304
Cdd:cd06174 187 ASSKSVLKLLKRVL--KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGlllSLFGLAGALGSLLLGLLSD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 305 RLSGkvdETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLG 384
Cdd:cd06174 265 RLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341
|
330 340 350
....*....|....*....|....*....|....*..
gi 487908851 385 RGMAPFVFCLIYFSK-GPAISFLTSGLVSFLFLLFIW 420
Cdd:cd06174 342 GAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
6-420 |
2.53e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.15 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 6 FVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSgdpvldqfadwtrilleassgdrslfvALFGGIVASLYSILQFIFAPI 85
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNS---------------------------ELLVPLLLTLPALFIALFAPL 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 86 WGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADITNEKDRAKGMGMIGAGVG 164
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGiGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 165 LGFIAGPPTGGLFAKINLDFLKLVFpdltftvfpasalaatIIALINLLMILFWFRETfdqKDLLEKKKIHPILGVFTSK 244
Cdd:cd17473 135 LGGVVFLLLGGALAEIGWRAPFLVY----------------LLALPVLILVLLFLPEP---ARKSKSAASPGAATAAALP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 245 NKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFtFVYIGMIIVLIQGGVFRRLSGKVDETKLIRIGTFSLL 324
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGL-ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 325 VGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVF-CLIYFSKGPAI 403
Cdd:cd17473 275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLgPLVNLTGGLSG 354
|
410
....*....|....*..
gi 487908851 404 SFLTSGLVSFLFLLFIW 420
Cdd:cd17473 355 AFLILGVLALVLAIVLL 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-423 |
5.01e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 73.02 E-value: 5.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGtMGGNISVASAAMADITN 148
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 149 EKDRAKGMGMIGAGVGLGFIAGpptgglfakinldflkLVFPDLTFTVFPASALAATIIALINLLMILFWFRETFDQKDL 228
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAIS----------------MVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 229 LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFeFSINFYLSQFLNYKPIEIgftFVYIGMIIVliqGGVFRRLSG 308
Cdd:cd17472 178 QISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFF-YILPLLLTQLGGGKGQLW---KVYLPAILI---GFILMVPFV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 309 KVDETK-----LIRIGTFSLLVGFFILYFVSNS-YQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLAS 382
Cdd:cd17472 251 IYAEKKgkmkqVFVSSILLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQF 330
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 487908851 383 LGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLK 423
Cdd:cd17472 331 LGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
65-422 |
9.08e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 69.18 E-value: 9.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 65 ALFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGS---FLGYVIWLFSGSFSFFVL--SRVITGTMGG-NISV 138
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRallAAVLALLALLGSLSLWLLlvLAFLLGIASAfFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 139 ASAAMADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFakinldflklvfpdLTFTVFPASALAATIIALINLLMILFW 218
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--------------VALLGPGGAFAINALSFLLSALLLLFI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 219 FRETFDQKDLLEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAF--SGFEFSINFYLSQFLNYKPIEIGF--TFVYIGMI 294
Cdd:cd06173 179 RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALlgGALTVLLPLLAKEVLGGGAAGYGLllAAFGVGAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 295 IVliqGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNL 374
Cdd:cd06173 259 LG---ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVF 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 487908851 375 GMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKL 422
Cdd:cd06173 336 SVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
69-426 |
1.31e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITN 148
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 149 EKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFLklvfpdltftvfpASALAATIIALINLLMILFWFRETFDQKDL 228
Cdd:COG0738 126 PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS-------------WHLPYLILAVLLLLLALLFLRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 229 LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVY--IGMIIVLIQGGVFRRl 306
Cdd:COG0738 193 EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLfwGGMTIGRFLGGFLLK- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 307 sgKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKeEQGTNLGMFRSLASLGRG 386
Cdd:COG0738 272 --RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGA 348
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 487908851 387 MAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPK 426
Cdd:COG0738 349 IGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
81-389 |
1.47e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 68.76 E-value: 1.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 81 IFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIG 160
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 161 AGVGLGFIAGPPTGGLFAKInldflkLVFPDLTFTVFPASALAATIIALINLLMIlfwfretfdqkdllekkkihpilgv 240
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQH------LGWRWIFWTAAPVAVLLAALVPLIDLRLL------------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 241 ftsKNKEVVLYSIFYFVFVFAFsgfeFSINFYLSQFLNY-KPIEIGFTFVYIG------MIIVLIQGGVFRRLSGKVDET 313
Cdd:cd17504 175 ---RRRNVLLANITALLAGFGM----FMVFQLLPQLLQLpTPTGFGLGITEAGllllpgALVMLIAGPLAGRLIARVGPR 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 314 KLIRIGTFSLLVGF-FILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAP 389
Cdd:cd17504 248 RVLLIGLVISAVGLlLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-426 |
1.72e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 65.29 E-value: 1.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 4 ISFVLFFTVFIDMMGFSVIFPIFPETLKIFLSQSgdpvldqfadwtrilleassgdrslfvalfgGIVASLYSILQFIFA 83
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-------------------------------GLLFAIPVLVGALLR 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 84 PIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADITNEKDRAKGMGMIGAG 162
Cdd:COG2223 58 IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGiGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 163 VGLGFIAGPPTGGLFAKinldflklvfpdlTFTVFPASALAATIIALInLLMILFWFRETFDQKDLLEKKKIHPILGVFt 242
Cdd:COG2223 138 GNLGAAVAAFLAPLLIA-------------AFGWRNAFLILGILLLVV-AVLAWLFLRDPPAGAAAAAKASLRDQLEAL- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 243 sKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGF--TFVYIGMIIVLIQGGvfrRLSGKVDETKLIRIGT 320
Cdd:COG2223 203 -RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLlaALFALLGALGRPLGG---WLSDRIGGRRVLLIVF 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 321 FSLLVGFFILYFVSNSYQLFISLTF-LASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIY-FS 398
Cdd:COG2223 279 ALMALGLLLLALALGSLWLFLVLFLlLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdAT 358
|
410 420
....*....|....*....|....*...
gi 487908851 399 KGPAISFLTSGLVSFLFLLFIWKLKQPK 426
Cdd:COG2223 359 GSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
69-420 |
7.27e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 63.33 E-value: 7.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVItGTMGGNISVAS--AAMAD 145
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIL-ERLGKGIRTPPrdALLAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 146 ITNEKDRAKGMGMIGAGVGLGFIAGPptggLFAKINLDFLKLVFPdltfTVFpasaLAATIIALINLLMILFWFRETFDQ 225
Cdd:cd17370 116 ATPPSGRGKAFGLHRALDTLGAVLGP----LLAALLLYLLGGNYR----TIF----LLAAIPALLALLILLFVVKEYPRP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 226 KDLLEKKKihpiLGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSInfYLSQFLNYKPIEIGFTFVyIGMIIVLIQGGVFRR 305
Cdd:cd17370 184 PKLRKKSK----KTSLKKLPKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALIPLLYA-LFNLVYALAAYPAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGR 385
Cdd:cd17370 257 LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW 336
|
330 340 350
....*....|....*....|....*....|....*
gi 487908851 386 GMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17370 337 LLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
85-420 |
7.98e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.36 E-value: 7.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 85 IWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMA-DITNEKDRAKGMGMIGAGV 163
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 164 GLGFIAGPPTGGLFakinldflklvfpdLTFTVFPASALAATIIALINLLMILFWFRETFDQKDllEKKKIHPILGVFTS 243
Cdd:cd17320 133 AIAPALAPLLGGLL--------------LLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEK--RKPLLSSLLRAYKR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 244 --KNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFvyIGMIIVLIQGGVF-RRLSGKVDETKLIRIGT 320
Cdd:cd17320 197 vlKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF--ALNAIALILGSLLnGRLVRRFGPRRLLRLGL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 321 FSLLVGFFILYFVS-----NSYQLFISLTFLASGSALLHPSLSTLVsLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLI 395
Cdd:cd17320 275 LLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLA-LEPFPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
330 340
....*....|....*....|....*
gi 487908851 396 YFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17320 354 PNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
71-384 |
9.90e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 62.58 E-value: 9.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 71 VASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNI-SVASAAMADITNE 149
Cdd:cd17502 35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 150 KDRAKGMGMIGAGVGLGFIAGPPTGGLFAK---------INLdflklvfpdltftvfPASALAATIIALINLLMIlfwfr 220
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFTDhlswrwcfyINL---------------PIGGLALALLRTILLSSI----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 221 etfdqkdllekkkihpilgvftsknkevvlysifyfvFVFAFSGFEFSINFYLSQF----LNYKPIEIGF--TFVYIGMI 294
Cdd:cd17502 175 -------------------------------------FGFLFGGALFGLIYYLPLYfqlvLGDSATKSGVrlLPLIIGLV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 295 IVLIQGGVFRRLSGKVdeTKLIRIGTFSLLVGFFILYF--VSNSYQLFISLTFLAS-GSALLHPSLSTLVSLVSGKEEQG 371
Cdd:cd17502 218 IGSIISGALISKTGRY--KPLIVIGTILMSVGAGLLTTltLDTSKWLLIGYLILLGlGLGIGFQQPLVAVQNAVPPADVG 295
|
330
....*....|...
gi 487908851 372 TNLGMFRSLASLG 384
Cdd:cd17502 296 VATATNTFFRSLG 308
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
75-396 |
1.67e-10 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 62.30 E-value: 1.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 75 YSILQFIF----APIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFS------FFVLSRVITGTMGGNISVASAAMA 144
Cdd:cd17386 35 MNLMGSIPplfsSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTtvpsvwWFYLSAIPLALFGGFTAFLSASFA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 145 ---DITNEKDRAKGMGMIGAGVGLG-FIAGPPTGGLFAKINldflklvfpdltftvFPASALAATIIALINLLMILFWFr 220
Cdd:cd17386 115 yisDISSEKKRTYRMAILEVALGLGgFLGSLLSGHLFKALG---------------YAWSFSISAALLLIALLYILFFL- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 221 etfdqkdllekkkihpilgvftsknKEVVLYSIFYFVFVFAFSGfEFSINFYLSQF---LNYKPIEIGFTFVYIGMIIVL 297
Cdd:cd17386 179 -------------------------TLLILLLLAAFLTIFVLSG-ESDVLYLFVLEkfaWNVKDFSYFSTLGSLIYLTGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 298 IQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSaLLHPSLSTLVSLVSGKEEQGTNLGMF 377
Cdd:cd17386 233 LGGVLLLRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG-IVGPMIRSILSKLVPKSEQGKIFSLL 311
|
330
....*....|....*....
gi 487908851 378 RSLASLgrgmAPFVFCLIY 396
Cdd:cd17386 312 SVLESL----SPLVASPIY 326
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
69-388 |
3.45e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.46 E-value: 3.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-----RKPVLVLTSFGSFLGYVI------WLFSGSFSFFVLSRVITGTMGGNIS 137
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 138 VA-SAAMADIT-NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKInldflklvFPDLTFTVFPASALAATIIALINLLMI 215
Cdd:COG2211 129 IPySALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAA--------FGGDAALGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 216 LFWFRETFDQKDllEKKKIHPILGVFTsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVyIGMII 295
Cdd:COG2211 201 FFGTKERPVPEE--EKVSLKESLKALL-KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLA-LYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 296 VLIQGGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFV--SNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTN 373
Cdd:COG2211 277 ALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTG 356
|
330
....*....|....*...
gi 487908851 374 L---GMFRSLASLGRGMA 388
Cdd:COG2211 357 RrreGLYFGIFTFAIKLG 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
69-178 |
1.33e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADIT 147
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGiGAGGLMPGALALIAELF 131
|
90 100 110
....*....|....*....|....*....|.
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFA 178
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-178 |
1.31e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 6 FVLFFTVFIDMMGFSVIFPIFPetlkIFLSQSGDpvldqfADWTRIlleassgdrslfvalfgGIVASLYSILQFIFAPI 85
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLP----LYAAELGG------LSPAQI-----------------GLLFGAQGLASALSQPP 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 86 WGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAA-MADITNEKDRAKGMGMIGAGVG 164
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAlLADIVPPEGRGTAMGLFNTAFS 334
|
170
....*....|....
gi 487908851 165 LGFIAGPPTGGLFA 178
Cdd:cd17325 335 LGMVLGPLLGGFLY 348
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
69-418 |
3.36e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 55.33 E-value: 3.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-----RKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRV--------ITGTMGGN 135
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRCNsrigrRRPFILVGAPLAALGLILIPNAADIGLALGDGPrtwalvlfVLGIVLLD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 136 ISVAS------AAMADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGlfakinLDFLKLVFPDLTFTVFPASALAATIIAL 209
Cdd:cd17313 117 FAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGA------ILWDHNWFGFALGGNLKVPFYIGAIILL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 210 INLLMILFWFRE---TFDQKDLLEKKKIH----PILGVFTSKNKEVVLYSIFYFVFVFAFSGFEF------SINFYLSQF 276
Cdd:cd17313 191 VCVLVTLFFVKEpplSPEAGEHSENPSLGevlkSLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELfftdymGEEVYHGTS 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 277 LNYKPIEIGFTFVYIGMIIVLIQGGVFRRLSGKVDET----KLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSAL 352
Cdd:cd17313 271 AASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKigrkKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWAT 350
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487908851 353 LHPSLSTLVSLVSGKEE--QGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISF---LTSGLVSFLFLLF 418
Cdd:cd17313 351 ININPYPLVSDYHSESGrgQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFpvaAVASFLSLVGALF 421
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
66-413 |
8.93e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 53.77 E-value: 8.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 66 LFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMAD 145
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 146 ITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKinldflklvfpdlTFTVFPASALAATIIaLINLLMILFWFRETFdq 225
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAD-------------SYGLRPVFFITASVL-FLCFLVTLFCIRENF-- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 226 KDLLEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGfefSINFYLSQFLNYKPIEIGFTFVYIGMI------IVLIQ 299
Cdd:PRK09874 198 QPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATG---SIAPILTLYVRELAGNVSNIAFISGMIasvpgvAALLS 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 300 GGVFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRS 379
Cdd:PRK09874 275 APRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQS 354
|
330 340 350
....*....|....*....|....*....|....*
gi 487908851 380 LASLGRGMAPFVFCLIYFSKG-PAISFLTSGLVSF 413
Cdd:PRK09874 355 FRDIGNVTGPLMGAAISANYGfRAVFLVTAGVVLF 389
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
71-181 |
1.27e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.78 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 71 VASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEK 150
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNK 116
|
90 100 110
....*....|....*....|....*....|.
gi 487908851 151 DRAKGMGMIGAGVGLGFIAGPPTGGLFAKIN 181
Cdd:cd06179 117 YRGLVQGVVNLVASPGSALGPLIAGALVEAN 147
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
70-303 |
3.65e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.81 E-value: 3.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 70 IVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGN-ISVASAAMADITN 148
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSpLAIGAGTIADLFT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 149 EKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKinldflklvfpdltFTVFPASALAATIIALINLLMILFWFRETFdqkdl 228
Cdd:cd17323 118 PEERGKAMGVYSLGPLLGPALGPIIGGFITQ--------------SLGWRWIFWFLAIISGFCLILIFLFLPIVL----- 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 229 lekkkihpILGVFTSknkevVLYSIFYFVFVfafsgfefSINFYLSQFLNYKPIEIGFTFV--YIGMIIVLIQGGVF 303
Cdd:cd17323 179 --------LLGLYVG-----LVYAILYLFLT--------AFPYVFGEVYGFSPGEVGLMYLpiGIGALIGSIIGGRL 234
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
81-360 |
4.52e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 51.81 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 81 IFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGN-ISVASAAMADITNEKDRAKGMGMI 159
Cdd:cd17503 46 IMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 160 GAGVGLGFIAGPPTGGLFAK---------INLdflklvfpdltftvfPASALAATIIALINllmilfwfretfdqkdlle 230
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTDnlswrwifyINL---------------PIGILALLLAPLLD------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 231 kkkihpiLGVFtsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYIGMIIVLIQgGVFRRLSGKV 310
Cdd:cd17503 172 -------LRLF--KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILS-PLVGRLLDKF 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 487908851 311 DETKLIRIGTFSLLVGFFILYFV---SNSYQLFISLTFLASGSALLHPSLSTL 360
Cdd:cd17503 242 GPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
69-420 |
6.25e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMADIT 147
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGvAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFakINLDFLKLVFpdltftvfpasalaaTIIALINLLMILFWFRetfdqkd 227
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWL--LLLFGWRWAF---------------IIEGLLGLLLAVLWWF------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 llekkkihpilgvftsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGF--TFVYIGMIIVLIQGGVFRR 305
Cdd:cd17319 177 ----------------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLlaAIPFLAGAIGMILGGRLSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGR 385
Cdd:cd17319 241 RLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG 320
|
330 340 350
....*....|....*....|....*....|....*.
gi 487908851 386 GMAPFVF-CLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17319 321 FVAPLLIgYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
87-391 |
1.75e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.63 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 87 GRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEKDRAKGMGMIGAGVGLG 166
Cdd:cd17333 52 GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 167 FIAGPPTGGLFAKINLDFlklvfpdltftvfpasALAATIIALINLLMILFWFRETFDQKDL----LEKKKIHPILGVFT 242
Cdd:cd17333 132 ALIGPLIATSLLTSELSW----------------SWAYLIIGLIYLLLAILILLTLFPELPSarnpQQSVGAFSASASRL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 243 SKNKEVVLYSIFYFVFVFAFSGFEFSINFYL--SQFLNYKPIEIGFTFVYIGMIIVLIQGGvfrRLSGKVDETKLIRIGT 320
Cdd:cd17333 196 LRNPSIILGALALFLYVGAETAFSSWVPSYLveKKHVSDGLAGYLLSGFWVGITIGRLLGG---PISRRIKPHTLLVLSG 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487908851 321 FSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKeEQGTNLGMFRSLASLGRGMAPFV 391
Cdd:cd17333 273 SGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFI 342
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
6-176 |
3.21e-06 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 49.11 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 6 FVLFFTVFIDMMGFSVIFPIFPEtlkiFLSQSGdpvldqfadwtRIlleassgdrslfvalfgGIVASLYSILQFIFAPI 85
Cdd:cd17384 3 VIVYVALLLDNMLLTVVVPIIPD----YLNENV-----------RV-----------------GLLFASKALVQLITNPI 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 86 WGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM-ADI-TNEKDRAKGMGMIGAGV 163
Cdd:cd17384 51 VGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMlASLyPDDKERGKAMGIALGGL 130
|
170
....*....|...
gi 487908851 164 GLGFIAGPPTGGL 176
Cdd:cd17384 131 ALGVLVGPPFGGV 143
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
65-170 |
3.56e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 48.69 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 65 ALFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGT-MGGNISVASAAM 143
Cdd:cd17370 233 AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAV 312
|
90 100
....*....|....*....|....*..
gi 487908851 144 ADITNEKDRAKGMGMIGAGVGLGFIAG 170
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLA 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
252-432 |
3.60e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 252 SIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIG--FTFVYIGMIIVLIQGGvfrRLSGKVDETKLIRIGTFSLLVGFFI 329
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGllLTLFSLGYALAQPLAG---RLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 330 LYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTSG 409
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180
....*....|....*....|...
gi 487908851 410 LVSFLFLLFIWKLKQPKLVESKN 432
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPK 181
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
69-418 |
4.81e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADIT 147
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFA-KINLDFLKLVfpdltftvfpasALAATIIALINLLMIlfwfretfDQK 226
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLL------------AALAGVLGFILSLFI--------KEE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 227 DLLEKKKIHPILGVFTS-KNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGftfvyIGMIIVLIQGGVFRR 305
Cdd:cd17490 174 RREKKPVLTELKELLSVlKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLG-----LLSIIYLLPNALASL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 306 LSGKVDETKLIRIGTfsLLVGFFILY-------FVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFR 378
Cdd:cd17490 249 LSGTLFYKKLGERNT--IIIGFLLLGaycflipFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQ 326
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 487908851 379 SLASLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLF 418
Cdd:cd17490 327 AIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
69-222 |
5.46e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 5.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGR--KPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNISVASAAMAD 145
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGfGLGGAFGLLWALAAE 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 146 ITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFakinldflklvfpdLTFTVFPASALAATIIALINLLMILFWFRET 222
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYL--------------LDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
69-420 |
6.71e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.00 E-value: 6.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNI-SVASAAMADIT 147
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVqPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVglgfiagpPTGGLFAKINLDFLKLVFPdltftvFPASALAATIIALINLLMILFWFRETfDQKD 227
Cdd:cd17475 114 PPRERGLAMGIRQTGV--------PLGGALAAALLPPLALHYG------WRAAFVVAGLVSILAAVLFWLFYREP-PAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 LLEKKKIHPILGVftsknKEVVLYSIFYFVFVFAF--SGFEFSINFYLSQFLNYkpiEIGFTFVYIGMIIVLIQGG---- 301
Cdd:cd17475 179 AATESASTLLRSL-----KEVLRNRDVWLIAIAGAllVAPQFALLTFLLLFLHD---HLGLSVVAAGALLAVAQLGgalg 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 302 --VFRRLSGKVDE------TKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTN 373
Cdd:cd17475 251 riGLGRVSDRVFGgrrrpvLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 487908851 374 LGMFRSLASLGRGMAPFVF-CLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
69-419 |
7.95e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 7.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVAS-AAMADIT 147
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAkinldflklVFPDLTFtvfpasaLAATIIALINLLMILFWFREtfdQKD 227
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVG---------TAGALPF-------LIAAVLLLLALVPLLLTRRA---APE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 228 LLEKKKIHPilgvftsknKEVVLYSIFYFVFVFAFSGFEFSIN----FYLSQF-LNYKPIEIGFTFVYIGMIIVLIQGGv 302
Cdd:cd17477 175 IEEAESISL---------RRLLRIAPLALLGAFVAGFLEGAFYsllpLYGLRLgLSVAQAALLLAAFVLGGLLLQWPLG- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 303 frRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSAL-LHP-SLSTLVSLVSGKEEQGTNlGMFRSL 380
Cdd:cd17477 245 --WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGpLYTlALALAGDRLPGDELVAAN-AALLLL 321
|
330 340 350
....*....|....*....|....*....|....*....
gi 487908851 381 ASLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFI 419
Cdd:cd17477 322 YGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
69-364 |
9.88e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 9.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITN 148
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 149 EKDRAKGMGMIGAGVGLGFIAGPPTGGLFakinldflklvfpdLTFTVFPASALAATIIALINLLMILFWfretfdQKDL 228
Cdd:cd17478 114 GGRRGLAMSIFSVGGNLGFALGPLIAAAL--------------VALFGGLGLLILLIIPGLAVALLLLRL------RPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 229 LEKKKIHPILGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFL---NYKPIEIG---FTFVYIGMIIVLIQGgv 302
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvqrGYSLVFAGlllSLFLFAGAIGTLIGG-- 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487908851 303 frRLSGKVDETKLIRIGTfsLLVGFFILYFVSNSYQLFISLTFLAsgSALLHPSLSTLVSLV 364
Cdd:cd17478 252 --PLSDRFGRRRVIIASL--LLAAPFLLLFLLTPGIWSYILLVLA--GFLLFASFPVTVVLA 307
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
69-420 |
1.69e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGT-MGGNISVASAAMADIT 147
Cdd:cd17316 39 GLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLDFL--KLVFpdltftvfpasalaatIIALINLLMILFWFRETfdq 225
Cdd:cd17316 119 PSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwRILF----------------LIGALPALLALLLRRRT--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 226 kdllekkkihpilgvftsknkevVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGF--TFVYIGMIIVLIQGGvf 303
Cdd:cd17316 180 -----------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLylLLISLGALVGALIAG-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 304 rRLSGKVDETKLIRIGTFSLLVGFFILYFV--SNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLA 381
Cdd:cd17316 235 -LLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLG 313
|
330 340 350
....*....|....*....|....*....|....*....
gi 487908851 382 SLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17316 314 RLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
58-168 |
2.61e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.03 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 58 GDRSLFVALfggiVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITG-TMGGNI 136
Cdd:cd17317 21 CDRDWLVAL----VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGvTSAGIF 96
|
90 100 110
....*....|....*....|....*....|..
gi 487908851 137 SVASAAMADITNEKDRAKGMGMIGAGVGLGFI 168
Cdd:cd17317 97 TVGFVLGMEIVGPKYRSFVGILFGLFWALGYM 128
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
65-179 |
3.24e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.68 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 65 ALFGGIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGS--FSFFVLSRVITGTMGGNISVASAA 142
Cdd:cd17353 248 AGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvaVLFVLGVALIGFCYGGGFALFPAL 327
|
90 100 110
....*....|....*....|....*....|....*..
gi 487908851 143 MADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAK 179
Cdd:cd17353 328 TADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY 364
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
69-218 |
4.75e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 4.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFS---FFVLSRVITGTMGGNISVASAAMAD 145
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNlwlLLVLAALAGIGLGAILVLPWAMLAD 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 146 I-------TNEKDRAKGMGMIGAGVGLGFIAGPPTGG-LFAKINLDFLKLVFPDLTFTVFPASALAATIIALINLLMILF 217
Cdd:COG2211 347 VvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGlLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
.
gi 487908851 218 W 218
Cdd:COG2211 427 Y 427
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
69-168 |
6.20e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.01 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAA-MADIT 147
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVlNTEFL 209
|
90 100
....*....|....*....|.
gi 487908851 148 NEKDRAKGMGMIGAGVGLGFI 168
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLV 230
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
81-396 |
1.42e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.80 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 81 IFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGS-FSFFVLSRVITGTMGGNIS-VASAAMADITNEKDRAKGMGM 158
Cdd:cd17355 53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERRRGLALGI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 159 IGAGVGLGFIAGPPTGGLFAKinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDQKDLLEKKKIHPIL 238
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIE-------------AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 239 GVF---TSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLsqflnykpIEIGFTFVYIGMIIVLIQGGVF--RRLSG----K 309
Cdd:cd17355 200 GSTlkeALRSASFWLLALAFFLCGFAVVGLIVHLVPYL--------ADRGISPAAAAVALALIGLFNIvgRLLSGwlgdR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 310 VDETKLIRIGTFSLLVGFFILYFVSNSYQ-LFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLGRGMA 388
Cdd:cd17355 272 YSPRRLLAASYALRALGLALLLLLPFPPLaLLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALG 351
|
....*...
gi 487908851 389 PFVFCLIY 396
Cdd:cd17355 352 PWLGGLLY 359
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
69-406 |
1.47e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 43.77 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGS---FLGYVIWLFSGSFSFFVLSRVITGTMgGNISVASAAMA 144
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAavlFLSVLFIPISLTFWWLALLVVLFSFF-WNAILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 145 DITNEKDRAKGMGMIGAGVGLGF-IAGPPTGGLFAKINLDFLklvfPDLTFTVFPASALAATIIALInllmilfwFRETF 223
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVGFaLSVFGLGALFDHYSVGLL----PSVLFYLFAALMLLSLLLPLA--------PPEME 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 224 DQKDLLEKKKIHPILgvftsKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQfLNYKPIEIGfTFVYIGMIIVLIQGGVF 303
Cdd:pfam12832 184 YESKGGSKAVFWNLL-----KQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLG-ALWALGVVAEIPLFFYA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 304 RRLSGKVDETKLIRIGTFSLLVGFFIL-YFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLA- 381
Cdd:pfam12832 257 HRLLRRFGHRNLLIIALLLTALRWLLYaFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYf 336
|
330 340
....*....|....*....|....*
gi 487908851 382 SLGRGMAPFVFCLIYFSKGPAISFL 406
Cdd:pfam12832 337 GLGGALGSLIGGQLWDLFGARFTFR 361
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
68-183 |
4.41e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 68 GGIVASLYSILQFIFAPIWGRISDHVGRKPVLVltsfgsfLGYVIWL-------FSGSFSFFVLSRVITGT-MGGNISVA 139
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILA-------VGILIWSaatllssFAPNFWQLLLFRALVGIgEASYSPIA 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 487908851 140 SAAMADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAKINLD 183
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGG 152
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
85-345 |
4.89e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 4.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 85 IWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMA-DITNEKDRAKGMGMIGAGV 163
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVrDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 164 GLGFIAGPPTGGlfakinldflkLVFPDLTF-TVFPASALAATIIalinLLMILFWFRETfdqKDLLEKKKIHPILGVFT 242
Cdd:TIGR00710 139 ALAPAVAPLLGG-----------YILVWLSWhAIFAFLSLAGILL----SALIFFILPET---LPYEARIQISTYFETFL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 243 S--KNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFVYigMIIVLIQGGVF-RRLSGKVDETKLIRIG 319
Cdd:TIGR00710 201 LllKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFAL--NIIAMIFGGFLnGRFIKKWGAKSLLRMG 278
|
250 260
....*....|....*....|....*.
gi 487908851 320 TFSLLVGFFILYFVSNSYQLFISLTF 345
Cdd:TIGR00710 279 LILFAVSAVLLEITAILGLGSWAMII 304
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
286-422 |
5.07e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 286 FTFVYIGMIIVLIQGGvfrRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVS 365
Cdd:COG2814 51 VTAYLLGAALGAPLAG---RLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 366 GKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKL 422
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
283-432 |
5.92e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 5.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 283 EIGFTFVYIGMIIVLIQGG------VFRRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPS 356
Cdd:cd17478 25 KLGLSYAQAGLLVSVFSITssllqpLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPE 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487908851 357 LSTLVSLVSGKeEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPKLVESKN 432
Cdd:cd17478 105 GARLASQAAGG-RRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK 179
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
71-385 |
8.59e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.48 E-value: 8.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 71 VASLYSILQFIFAPIWGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAMADITNEK 150
Cdd:cd17476 38 LAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 151 DRAKGMGM--IGAGVGLGFIAGPPTGGLFAkinldflklvfpdlTFTVFPASALAATIIALINLLMILFWFRETFDqkdl 228
Cdd:cd17476 118 GPRKNIVFslFGATAPLGFALGGVFGGLFA--------------QLAWWPWIFWFLAILAAIVAVAAIFWTSPSFI---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 229 lekkkihPILGVFtsknkevvlysifyFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTF--VYIGMIIVLIQGGvfrRL 306
Cdd:cd17476 180 -------AVLLAV--------------FLGWASFGIWVFYATQYFQNVRGYSPLLTSARFipMAIGGVLAAITVG---FL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 307 SGKVDETKLIRIGTFSLLVG--FFILYFVSNSY--QLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLAS 382
Cdd:cd17476 236 IARLPPSYIMAISMVAFLVGpiLFATMPVHQTYwaQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVN 315
|
...
gi 487908851 383 LGR 385
Cdd:cd17476 316 YGI 318
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
46-175 |
1.25e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 40.95 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 46 ADWTRILLEASSGDRSLFVALfGGIVASLYSILQFifapiwGRISDHVGRKPVLVLTSFGSFLGYVIWLFSGSFS----F 121
Cdd:cd17449 52 ADPLQQEVETLTAHWNLYINL-GGFLVGLFSVTLL------GPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQlhvaY 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 487908851 122 FVLSRVITGTMGG-NISVAS--AAMADITNEKDRAKGMGMIGAGVGLGFIAGPPTGG 175
Cdd:cd17449 125 FLIGRILSGLLGDfNGILAGcfAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGG 181
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
286-429 |
1.82e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 286 FTFVYIGMIIVLIQGGVF-RRLSGKvdetKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLV 364
Cdd:COG0738 49 LFAFFLGYLLASLPAGRLiDRFGYK----RGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487908851 365 sGKEEQGTNLGMFRSLASLGRGMAPFVFCLIYFSKGPA---ISFLTSGLVSFLFLLFIWKLKQPKLVE 429
Cdd:COG0738 125 -GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLswhLPYLILAVLLLLLALLFLRSKLPEIEE 191
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
65-176 |
1.88e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 65 ALFGGIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGSFLGYVIWLFSGSFSFFVLSRVITGTMGGNISVASAAM 143
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLI 328
|
90 100 110
....*....|....*....|....*....|....
gi 487908851 144 ADIT-NEKDRAKGMGMIGAGVGLGFIAGPPTGGL 176
Cdd:COG2807 329 GLRArTPAEAAALSGMAQSVGYLLAALGPLLVGA 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
305-426 |
2.36e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 305 RLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLASLG 384
Cdd:cd17325 53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLG 132
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 487908851 385 RGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIWKLKQPK 426
Cdd:cd17325 133 FLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP 174
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
69-420 |
2.48e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISDHVG-RKPVLVLTSFGSFLGYVIWLF-SGSFSFFVLSRVITGTMGGNIS--VASAAMA 144
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFvAQIFWLLLLLVILGAFFSAPVVplVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 145 DITNEKDRAKGMGMIGAgvgLGFIAGPP-TGGLFAKINLDflklVFPDLTFTVFPASALAATIIALinllmilfwfRETF 223
Cdd:cd17335 115 YLGEERERYGKQRLWGS---IGFGIAALlVGILIDRSSTY----KNYTIAFYVFAVLMLLALLLAL----------KFPF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 224 DQKDLLEKKKIHPILGVFTSKNKEVVLYSIFyfvFVFAFSGFEFSINFYLSQFLNYKPIEIGFTFV--YIGMIIVLIQGG 301
Cdd:cd17335 178 RPKHPEPNENTGGLLALLRNPRVLAFLLVAF---LMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTvgVVSEIPFFFFSS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 302 vfrRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSGKEEQGTNLGMFRSLA 381
Cdd:cd17335 255 ---RLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLY 331
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 487908851 382 S-LGRGMAPFVFCLIYFSKGPAISFLTSGLVSFLFLLFIW 420
Cdd:cd17335 332 FgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
69-340 |
4.92e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 69 GIVASLYSILQFIFAPIWGRISD-HVGRKPVLVLTSFGSFLGYViwLFSGSFSFFVLsrVITGTMggNISVASAAM---- 143
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGYL--LFAFLRNYWVL--LLVGVV--LLSLGAAAFpqlf 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 144 ------ADITNEKDRAKGMGMIGAGVGLGFIAGPPTGGLFAkINLDFlKLVFpdltftvfpasaLAATIIALINLLMILF 217
Cdd:cd17471 109 alareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLL-DVLGF-TGLF------------LLAALLYLVVALLVLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487908851 218 WFREtfDQKDLLEKKKIHPilGVFTSKNKEVVLYSIFYFVFVFAFSGFEFSINFYLSQFLNYKPIEIGFTF-----VYIG 292
Cdd:cd17471 175 LLPS--VKPPAQKATPASS--LVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFglaaaLEIP 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 487908851 293 MIIVLIqggvfrRLSGKVDETKLIRIGTFSLLVGFFILYFVSNSYQLF 340
Cdd:cd17471 251 IMLLAG------LLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLI 292
|
|
| |
