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Conserved domains on  [gi|487709256|ref|WP_001793488|]
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MULTISPECIES: DEAD/DEAH box helicase [Staphylococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 10-226 2.01e-126

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 365.52  E-value: 2.01e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNEKYGLFLDMGLGKTVSTLTAFSELQLLD-TKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKVSLVL 88
Cdd:cd18013    1 PHPYQKVAINFIIEHPYCGLFLDMGLGKTVTTLTALSDLQLDDfTRRVLVIAPLRVARSTWPDEVEKWNHLRNLTVSVAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  89 GTPKERNDALNTEADIYVTNKENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKKLPLINRFIGLTGTPSPNS 168
Cdd:cd18013   81 GTERQRSKAANTPADLYVINRENLKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGTPSPNG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 487709256 169 LQDLWAQVYLIDRGERLESSFSRYRERYFKPTHQVSEHIFKWELRDGSEEKIYKQIED 226
Cdd:cd18013  161 LMDLWAQIALLDQGERLGRSITAYRERWFDPDKRNGQQVFKYKPKPGAEEEIYRAISD 218
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 303-420 4.23e-04

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd18793:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 40.15  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 303 VRLIHDKKLDKLEEIIEE--SQGQPILLF----------------YNFKH----------DKERILQRFKEattledsny 354
Cdd:cd18793    5 IEEVVSGKLEALLELLEElrEPGEKVLIFsqftdtldileealreRGIKYlrldgstsskERQKLVDRFNE--------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487709256 355 kerwNSGDIKLLIAHPAsAGHGLNLQQGGHIIVwFGLTWSLELYQQANARLYRQGQNHTTIIHHIM 420
Cdd:cd18793   76 ----DPDIRVFLLSTKA-GGVGLNLTAANRVIL-YDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
 
Name Accession Description Interval E-value
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 10-226 2.01e-126

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 365.52  E-value: 2.01e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNEKYGLFLDMGLGKTVSTLTAFSELQLLD-TKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKVSLVL 88
Cdd:cd18013    1 PHPYQKVAINFIIEHPYCGLFLDMGLGKTVTTLTALSDLQLDDfTRRVLVIAPLRVARSTWPDEVEKWNHLRNLTVSVAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  89 GTPKERNDALNTEADIYVTNKENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKKLPLINRFIGLTGTPSPNS 168
Cdd:cd18013   81 GTERQRSKAANTPADLYVINRENLKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGTPSPNG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 487709256 169 LQDLWAQVYLIDRGERLESSFSRYRERYFKPTHQVSEHIFKWELRDGSEEKIYKQIED 226
Cdd:cd18013  161 LMDLWAQIALLDQGERLGRSITAYRERWFDPDKRNGQQVFKYKPKPGAEEEIYRAISD 218
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 5-436 5.56e-51

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 183.12  E-value: 5.56e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   5 AIDFKPHSYQKYAIDKVIDNEKYGL-FL---DMGLGKTVSTLTAFSELQLL-DTKKMLVIAPKQVaKDTWVDEVDKWNHl 79
Cdd:COG0553  237 GLKATLRPYQLEGAAWLLFLRRLGLgGLladDMGLGKTIQALALLLELKERgLARPVLIVAPTSL-VGNWQRELAKFAP- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  80 nHLKVSLVLGTPK-ERNDALNTEADIYVTNKENTKWLCDQYKkEWPFDMVVIDELSTFKSPKSQRFKSIKKkLPlINRFI 158
Cdd:COG0553  315 -GLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLA-AVDWDLVILDEAQHIKNPATKRAKAVRA-LK-ARHRL 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 159 GLTGTPSPNSLQDLWAQVYLIDRGeRLESsFSRYRERYFKPthqvsehifKWELRDGSEEKIYKQIEDICLS-MKAKDYL 237
Cdd:COG0553  391 ALTGTPVENRLEELWSLLDFLNPG-LLGS-LKAFRERFARP---------IEKGDEEALERLRRLLRPFLLRrTKEDVLK 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 238 DMPDRVDTKQTVVLSEKERKVYEELeKNYILESEEEGTVVAQNGASLS--QKLLQLSNG-AVYTDEEDVRLIHDKKLDKL 314
Cdd:COG0553  460 DLPEKTEETLYVELTPEQRALYEAV-LEYLRRELEGAEGIRRRGLILAalTRLRQICSHpALLLEEGAELSGRSAKLEAL 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 315 EEIIEE--SQGQPILLFYNFKhdkeRILQRFKEAttLEDSNY-----------KER-------WNSGDIKLLIAHPASAG 374
Cdd:COG0553  539 LELLEEllAEGEKVLVFSQFT----DTLDLLEER--LEERGIeyaylhggtsaEERdelvdrfQEGPEAPVFLISLKAGG 612

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487709256 375 HGLNLQQGGHIIVwFGLTWSLELYQQANARLYRQGQNHTTIIHHIMTDNTIDQRVYKALQNK 436
Cdd:COG0553  613 EGLNLTAADHVIH-YDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEK 673
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 29-293 7.40e-20

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 89.28  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   29 LFLDMGLGKTVST---LTAFSELQLLDTKKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKERNDALN-----T 100
Cdd:pfam00176  22 LADEMGLGKTLQTislLLYLKHVDKNWGGPTLIVVPLSLLHN-WMNEFERWVSPPALRVVVLHGNKRPQERWKNdpnflA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  101 EADIYVTNKENTKWLCDQYKK-EWpfDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQDLWAQVYLI 179
Cdd:pfam00176 101 DFDVVITTYETLRKHKELLKKvHW--HRIVLDEGHRLKNSKSKLSKALKS-LKTRNRWI-LTGTPLQNNLEELWALLNFL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  180 drGERLESSFSRYRERYFKPthqvsehiFKWELRDGSEEKIYKQIEDICL-SMKAKDYLDMPDRVDTKQTVVLSEKERKV 258
Cdd:pfam00176 177 --RPGPFGSLSTFRNWFDRP--------IERGGGKKGVSRLHKLLKPFLLrRTKKDVEKSLPPKVEYILFCRLSKLQRKL 246

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 487709256  259 YeeleKNYILESE----EEGTVVAQNGASLSQKLLQLSN 293
Cdd:pfam00176 247 Y----QTFLLKKDlnaiKTGEGGREIKASLLNILMRLRK 281
DEXDc smart00487
DEAD-like helicases superfamily;
8-184 1.70e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 80.61  E-value: 1.70e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256     8 FKPHSYQKYAIDKVIDNEKYG-LFLDMGLGKT-VSTLTAFSELQLLDTKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKVS 85
Cdd:smart00487   7 EPLRPYQKEAIEALLSGLRDViLAAPTGSGKTlAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256    86 LVLG---TPKERNDALNTEADIYVTNKEN-TKWLCDQYKKEWPFDMVVIDELSTFKSPK-SQRFKSIKKKLPLINRFIGL 160
Cdd:smart00487  87 GLYGgdsKREQLRKLESGKTDILVTTPGRlLDLLENDKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLKLLPKNVQLLLL 166

                          170       180
                   ....*....|....*....|....*..
gi 487709256   161 TGTPS---PNSLQDLWAQVYLIDRGER 184
Cdd:smart00487 167 SATPPeeiENLLELFLNDPVFIDVGFT 193
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 20-174 4.19e-04

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 42.87  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   20 KVIDNEKYGLFLD-MGLGKTVSTLTAFSELQLLD--TKKMLVIAPKQVAKDtWVDEVDKWNHLnhLKVSLVLGTPKERND 96
Cdd:PLN03142  183 RLYENGINGILADeMGLGKTLQTISLLGYLHEYRgiTGPHMVVAPKSTLGN-WMNEIRRFCPV--LRAVKFHGNPEERAH 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   97 ALNT-----EADIYVTN-----KENTKWlcdqykKEWPFDMVVIDELSTFKSPKSqRFKSIKKKLPLINRFIgLTGTPSP 166
Cdd:PLN03142  260 QREEllvagKFDVCVTSfemaiKEKTAL------KRFSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYRLL-ITGTPLQ 331


                  ....*...
gi 487709256  167 NSLQDLWA 174
Cdd:PLN03142  332 NNLHELWA 339
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 303-420 4.23e-04

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 40.15  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 303 VRLIHDKKLDKLEEIIEE--SQGQPILLF----------------YNFKH----------DKERILQRFKEattledsny 354
Cdd:cd18793    5 IEEVVSGKLEALLELLEElrEPGEKVLIFsqftdtldileealreRGIKYlrldgstsskERQKLVDRFNE--------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487709256 355 kerwNSGDIKLLIAHPAsAGHGLNLQQGGHIIVwFGLTWSLELYQQANARLYRQGQNHTTIIHHIM 420
Cdd:cd18793   76 ----DPDIRVFLLSTKA-GGVGLNLTAANRVIL-YDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
 
Name Accession Description Interval E-value
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 10-226 2.01e-126

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 365.52  E-value: 2.01e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNEKYGLFLDMGLGKTVSTLTAFSELQLLD-TKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKVSLVL 88
Cdd:cd18013    1 PHPYQKVAINFIIEHPYCGLFLDMGLGKTVTTLTALSDLQLDDfTRRVLVIAPLRVARSTWPDEVEKWNHLRNLTVSVAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  89 GTPKERNDALNTEADIYVTNKENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKKLPLINRFIGLTGTPSPNS 168
Cdd:cd18013   81 GTERQRSKAANTPADLYVINRENLKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGTPSPNG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 487709256 169 LQDLWAQVYLIDRGERLESSFSRYRERYFKPTHQVSEHIFKWELRDGSEEKIYKQIED 226
Cdd:cd18013  161 LMDLWAQIALLDQGERLGRSITAYRERWFDPDKRNGQQVFKYKPKPGAEEEIYRAISD 218
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 5-436 5.56e-51

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 183.12  E-value: 5.56e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   5 AIDFKPHSYQKYAIDKVIDNEKYGL-FL---DMGLGKTVSTLTAFSELQLL-DTKKMLVIAPKQVaKDTWVDEVDKWNHl 79
Cdd:COG0553  237 GLKATLRPYQLEGAAWLLFLRRLGLgGLladDMGLGKTIQALALLLELKERgLARPVLIVAPTSL-VGNWQRELAKFAP- 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  80 nHLKVSLVLGTPK-ERNDALNTEADIYVTNKENTKWLCDQYKkEWPFDMVVIDELSTFKSPKSQRFKSIKKkLPlINRFI 158
Cdd:COG0553  315 -GLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRDIELLA-AVDWDLVILDEAQHIKNPATKRAKAVRA-LK-ARHRL 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 159 GLTGTPSPNSLQDLWAQVYLIDRGeRLESsFSRYRERYFKPthqvsehifKWELRDGSEEKIYKQIEDICLS-MKAKDYL 237
Cdd:COG0553  391 ALTGTPVENRLEELWSLLDFLNPG-LLGS-LKAFRERFARP---------IEKGDEEALERLRRLLRPFLLRrTKEDVLK 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 238 DMPDRVDTKQTVVLSEKERKVYEELeKNYILESEEEGTVVAQNGASLS--QKLLQLSNG-AVYTDEEDVRLIHDKKLDKL 314
Cdd:COG0553  460 DLPEKTEETLYVELTPEQRALYEAV-LEYLRRELEGAEGIRRRGLILAalTRLRQICSHpALLLEEGAELSGRSAKLEAL 538

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 315 EEIIEE--SQGQPILLFYNFKhdkeRILQRFKEAttLEDSNY-----------KER-------WNSGDIKLLIAHPASAG 374
Cdd:COG0553  539 LELLEEllAEGEKVLVFSQFT----DTLDLLEER--LEERGIeyaylhggtsaEERdelvdrfQEGPEAPVFLISLKAGG 612

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487709256 375 HGLNLQQGGHIIVwFGLTWSLELYQQANARLYRQGQNHTTIIHHIMTDNTIDQRVYKALQNK 436
Cdd:COG0553  613 EGLNLTAADHVIH-YDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEK 673
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 10-180 2.59e-30

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 115.74  E-value: 2.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNEKYG----LFLDMGLGKTVSTLTAFSELQLLDTKKM--LVIAPKQVaKDTWVDEVDKWnhLNHLK 83
Cdd:cd17919    1 LRPYQLEGLNFLLELYENGpggiLADEMGLGKTLQAIAFLAYLLKEGKERGpvLVVCPLSV-LENWEREFEKW--TPDLR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  84 VSLVLGTPKERNDALNTE----ADIYVTNKENTKWLCDQYKKeWPFDMVVIDELSTFKSPKSQRFKSIkKKLPLINRfIG 159
Cdd:cd17919   78 VVVYHGSQRERAQIRAKEkldkFDVVLTTYETLRRDKASLRK-FRWDLVVVDEAHRLKNPKSQLSKAL-KALRAKRR-LL 154

                        170       180
                 ....*....|....*....|.
gi 487709256 160 LTGTPSPNSLQDLWAQVYLID 180
Cdd:cd17919  155 LTGTPLQNNLEELWALLDFLD 175
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 12-199 4.03e-22

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 94.17  E-value: 4.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  12 SYQKYAIDKVIDNEKYGL--FL--DMGLGKTVSTLTAF-SELQLLDTKKMLVIAPKQVAKdTWVDEVDKWNhlNHLKVSL 86
Cdd:cd18012    7 PYQKEGFNWLSFLRHYGLggILadDMGLGKTLQTLALLlSRKEEGRKGPSLVVAPTSLIY-NWEEEAAKFA--PELKVLV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  87 VLGTPKER-NDALNTEADIYVTN----KENTKWLCDQykkewPFDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLT 161
Cdd:cd18012   84 IHGTKRKReKLRALEDYDLVITSygllRRDIELLKEV-----KFHYLVLDEAQNIKNPQTKTAKAVKA-LKADHRLA-LT 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 487709256 162 GTPSPNSLQDLWAQVYLIDRGerLESSFSRYRERYFKP 199
Cdd:cd18012  157 GTPIENHLGELWSIFDFLNPG--LLGSYKRFKKRFAKP 192
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 29-293 7.40e-20

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 89.28  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   29 LFLDMGLGKTVST---LTAFSELQLLDTKKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKERNDALN-----T 100
Cdd:pfam00176  22 LADEMGLGKTLQTislLLYLKHVDKNWGGPTLIVVPLSLLHN-WMNEFERWVSPPALRVVVLHGNKRPQERWKNdpnflA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  101 EADIYVTNKENTKWLCDQYKK-EWpfDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQDLWAQVYLI 179
Cdd:pfam00176 101 DFDVVITTYETLRKHKELLKKvHW--HRIVLDEGHRLKNSKSKLSKALKS-LKTRNRWI-LTGTPLQNNLEELWALLNFL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  180 drGERLESSFSRYRERYFKPthqvsehiFKWELRDGSEEKIYKQIEDICL-SMKAKDYLDMPDRVDTKQTVVLSEKERKV 258
Cdd:pfam00176 177 --RPGPFGSLSTFRNWFDRP--------IERGGGKKGVSRLHKLLKPFLLrRTKKDVEKSLPPKVEYILFCRLSKLQRKL 246

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 487709256  259 YeeleKNYILESE----EEGTVVAQNGASLSQKLLQLSN 293
Cdd:pfam00176 247 Y----QTFLLKKDlnaiKTGEGGREIKASLLNILMRLRK 281
DEXDc smart00487
DEAD-like helicases superfamily;
8-184 1.70e-17

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 80.61  E-value: 1.70e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256     8 FKPHSYQKYAIDKVIDNEKYG-LFLDMGLGKT-VSTLTAFSELQLLDTKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKVS 85
Cdd:smart00487   7 EPLRPYQKEAIEALLSGLRDViLAAPTGSGKTlAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256    86 LVLG---TPKERNDALNTEADIYVTNKEN-TKWLCDQYKKEWPFDMVVIDELSTFKSPK-SQRFKSIKKKLPLINRFIGL 160
Cdd:smart00487  87 GLYGgdsKREQLRKLESGKTDILVTTPGRlLDLLENDKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLKLLPKNVQLLLL 166

                          170       180
                   ....*....|....*....|....*..
gi 487709256   161 TGTPS---PNSLQDLWAQVYLIDRGER 184
Cdd:smart00487 167 SATPPeeiENLLELFLNDPVFIDVGFT 193
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 32-174 2.80e-15

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 75.10  E-value: 2.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTV---STLTAFSELQLLdtKKMLVIAPKQVAKdTWVDEVDKWNhlNHLKVSLVLGT-PKERNDALN---TEADI 104
Cdd:cd18001   27 DMGLGKTVqicAFLSGMFDSGLI--KSVLVVMPTSLIP-HWVKEFAKWT--PGLRVKVFHGTsKKERERNLEriqRGGGV 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487709256 105 YVTN----KENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQDLWA 174
Cdd:cd18001  102 LLTTygmvLSNTEQLSADDHDEFKWDYVILDEGHKIKNSKTKSAKSLRE-IPAKNRII-LTGTPIQNNLKELWA 173
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 10-209 2.18e-13

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 68.85  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNEKYGLFL--DMGLGKTVSTLTAFSELQLL-DTKKMLVIAPKQVAkDTWVDEVDKWNHLNHLkVSL 86
Cdd:cd18011    1 PLPHQIDAVLRALRKPPVRLLLadEVGLGKTIEAGLIIKELLLRgDAKRVLILCPASLV-EQWQDELQDKFGLPFL-ILD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  87 VLGTPKERNDALN--TEADIYVTN----KENTKWLCDQYKKEWpfDMVVIDEL----STFKSPKSQRFKSIKKklpLINR 156
Cdd:cd18011   79 RETAAQLRRLIGNpfEEFPIVIVSldllKRSEERRGLLLSEEW--DLVVVDEAhklrNSGGGKETKRYKLGRL---LAKR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 487709256 157 ---FIGLTGTPSPNSLQDLWAQVYLIDRGeRLESSFSRYRERYFKPThqVSEHIFK 209
Cdd:cd18011  154 arhVLLLTATPHNGKEEDFRALLSLLDPG-RFAVLGRFLRLDGLREV--LAKVLLR 206
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 25-202 4.01e-13

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 68.53  E-value: 4.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  25 EKYGL--FL--DMGLGKTVSTLTAF-------SELQLLDTKKMLVIAPKQVAkDTWVDEVDKWNHLNHLKVSLVLGTPKE 93
Cdd:cd17999   16 NKYNLhgILcdDMGLGKTLQTLCILasdhhkrANSFNSENLPSLVVCPPTLV-GHWVAEIKKYFPNAFLKPLAYVGPPQE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  94 RNDALN--TEADIYVTNKENTKWLCDQY-KKEWPFdmVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQ 170
Cdd:cd17999   95 RRRLREqgEKHNVIVASYDVLRNDIEVLtKIEWNY--CVLDEGHIIKNSKTKLSKAVKQ-LKANHRLI-LSGTPIQNNVL 170

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 487709256 171 DLWAQV------YLIDrgerlESSFsryRERYFKPTHQ 202
Cdd:cd17999  171 ELWSLFdflmpgYLGT-----EKQF---QRRFLKPILA 200
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 11-182 1.68e-12

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 66.46  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  11 HSYQKYAIDKVIDNEKYGLFLD-MGLGKTVSTLTA----FSELQLLdtkkmlVIAPKQVaKDTWVDEVDKWnhLNHLKVS 85
Cdd:cd18010    2 LPFQREGVCFALRRGGRVLIADeMGLGKTVQAIAIaayyREEWPLL------IVCPSSL-RLTWADEIERW--LPSLPPD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  86 LVLGTPKERNDALNTEADIYVTNKENTKWLCDQYKKEwPFDMVVIDELSTFKSPKSQRFKSIkkkLPLI---NRFIGLTG 162
Cdd:cd18010   73 DIQVIVKSKDGLRDGDAKVVIVSYDLLRRLEKQLLAR-KFKVVICDESHYLKNSKAKRTKAA---LPLLkraKRVILLSG 148

                        170       180
                 ....*....|....*....|
gi 487709256 163 TPSPNSLQDLWAQVYLIDRG 182
Cdd:cd18010  149 TPALSRPIELFTQLDALDPK 168
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 32-199 1.73e-12

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 67.02  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVST---LTAF---------SELQLLDTKKM----------LVIAPKQVAKdTWVDEVDKWNHLnhlKVSLVLG 89
Cdd:cd18005   27 DMGLGKTVQViafLAAVlgktgtrrdRENNRPRFKKKppassakkpvLIVAPLSVLY-NWKDELDTWGHF---EVGVYHG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  90 TPKERNDALNTEA---DIYVTNKEnTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKkLPlINRFIGLTGTPSP 166
Cdd:cd18005  103 SRKDDELEGRLKAgrlEVVVTTYD-TLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKE-LK-CKVRIGLTGTLLQ 179

                        170       180       190
                 ....*....|....*....|....*....|...
gi 487709256 167 NSLQDLWAQVYLIDRGerLESSFSRYRERYFKP 199
Cdd:cd18005  180 NNMKELWCLLDWAVPG--ALGSRSQFKKHFSEP 210
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 32-220 2.50e-12

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 66.54  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSEL-----QLLDT-KKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKERNDALN--TEAD 103
Cdd:cd18004   32 EMGLGKTLQAIALVWTLlkqgpYGKPTaKKALIVCPSSLVGN-WKAEFDKWLGLRRIKVVTADGNAKDVKASLDffSSAS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 104 IY---VTNKENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIkKKLPLINRFIgLTGTPSPNSLQDLWAQVYLID 180
Cdd:cd18004  111 TYpvlIISYETLRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKAL-NSLPCRRRLL-LTGTPIQNDLDEFFALVDFVN 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 487709256 181 RGerLESSFSRYRERYFKPthqvsehIFKWELRDGSEEKI 220
Cdd:cd18004  189 PG--ILGSLASFRKVFEEP-------ILRSRDPDASEEDK 219
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 32-176 7.18e-12

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 65.00  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTL-------------TAFSELQLLDTKKM------LVIAPKqVAKDTWVDEVDKWNHLNHLKVSLVLGTPK 92
Cdd:cd18008   22 EMGLGKTIQALalilatrpqdpkiPEELEENSSDPKKLylskttLIVVPL-SLLSQWKDEIEKHTKPGSLKVYVYHGSKR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  93 ERNDALNTEADIYVT---------NKENTKWLCDQYKKEWP--FDM----VVIDELSTFKSPKSQRFKSIkKKLPLINRF 157
Cdd:cd18008  101 IKSIEELSDYDIVITtygtlasefPKNKKGGGRDSKEKEASplHRIrwyrVILDEAHNIKNRSTKTSRAV-CALKAERRW 179

                        170
                 ....*....|....*....
gi 487709256 158 IgLTGTPSPNSLQDLWAQV 176
Cdd:cd18008  180 C-LTGTPIQNSLDDLYSLL 197
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 33-202 2.07e-11

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 63.85  E-value: 2.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  33 MGLGKTVSTLTAfseLQLL-----DTKKMLVIAPKQVAkDTWVDEVDKWN---HL-NHLKVSLVL-GTPKERNDALNT-- 100
Cdd:cd18007   35 MGLGKTLQVITF---LHTYlaaapRRSRPLVLCPASTL-YNWEDEFKKWLppdLRpLLVLVSLSAsKRADARLRKINKwh 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 101 ----------EADIYVTNKENT---------KWLCDqykkEWPfDMVVIDELSTFKSPKSQRFKSIKKKLPliNRFIGLT 161
Cdd:cd18007  111 keggvlligyELFRNLASNATTdprlkqefiAALLD----PGP-DLLVLDEGHRLKNEKSQLSKALSKVKT--KRRILLT 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 487709256 162 GTPSPNSLQDLWAQVYLIdRGERLESSfSRYRERYFKPTHQ 202
Cdd:cd18007  184 GTPLQNNLKEYWTMVDFA-RPKYLGTL-KEFKKKFVKPIEA 222
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 15-174 2.32e-09

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 57.48  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  15 KYAIDKVIDNEKYGLFLD-MGLGKTVSTLTafselqLLDTKKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKE 93
Cdd:cd18071   38 NFSQKKRPELVRGGILADdMGLGKTLTTIS------LILANFTLIVCPLSVLSN-WETQFEEHVKPGQLKVYTYHGGERN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  94 RNDALNTEADIYVTN------KENTKWLCDQYKKEWpfDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPN 167
Cdd:cd18071  111 RDPKLLSKYDIVLTTyntlasDFGAKGDSPLHTINW--LRVVLDEGHQIRNPNAQQTKAVLN-LSSERRWV-LTGTPIQN 186


                 ....*..
gi 487709256 168 SLQDLWA 174
Cdd:cd18071  187 SPKDLGS 193
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 32-194 5.23e-09

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 56.29  E-value: 5.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSEL--QLLDTKKMLVIAPKQVAkDTWVDEVDKWNhlNHLKVSLVLGTPKERndaLNTEADIYVTNK 109
Cdd:cd18006   27 EMGLGKTCQTISLLWYLagRLKLLGPFLVLCPLSVL-DNWKEELNRFA--PDLSVITYMGDKEKR---LDLQQDIKSTNR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 110 EN---TKW---LCDQ-YKKEWPFDMVVIDELSTFKSPKSQRFKSIKKKLplINRFIGLTGTPSPNSLQDLWAQVYLIDR- 181
Cdd:cd18006  101 FHvllTTYeicLKDAsFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFS--VDFRLLLTGTPIQNSLQELYALLSFIEPn 178

                        170
                 ....*....|....*.
gi 487709256 182 ---GERLESSFSRYRE 194
Cdd:cd18006  179 vfpKDKLDDFIKAYSE 194
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 32-179 1.40e-08

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 54.31  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSEL-QLLDTKKMLVIAPKQVAkDTWVDEVDKWnhLNHLKVSLVLGTPKE----RNDALN--TEADI 104
Cdd:cd17998   27 EMGLGKTIQVIAFLAYLkEIGIPGPHLVVVPSSTL-DNWLREFKRW--CPSLKVEPYYGSQEErkhlRYDILKglEDFDV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 105 YVT-------NKENTKWLcdqykKEWPFDMVVIDELSTFKSPKSQRFKSIkKKLPLINRFIgLTGTPSPNSLQDLWAQVY 177
Cdd:cd17998  104 IVTtynlatsNPDDRSFF-----KRLKLNYVVYDEGHMLKNMTSERYRHL-MTINANFRLL-LTGTPLQNNLLELMSLLN 176


                 ..
gi 487709256 178 LI 179
Cdd:cd17998  177 FI 178
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 32-174 1.69e-08

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 54.64  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQLLDTKK--MLVIAPKQVAkDTWVDEVDKWnhLNHLKVSLVLGTPKERNDALNT-----EADI 104
Cdd:cd17997   30 EMGLGKTLQTISLLGYLKHYKNINgpHLIIVPKSTL-DNWMREFKRW--CPSLRVVVLIGDKEERADIIRDvllpgKFDV 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 105 YVTNKENTKwLCDQYKKEWPFDMVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQDLWA 174
Cdd:cd17997  107 CITSYEMVI-KEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRL-FNSRNRLL-LTGTPLQNNLHELWA 173
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
7-164 5.77e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 55.03  E-value: 5.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   7 DFKPHSYQKYAIDKVID----NEKYGLF-LDMGLGKTVSTLTAFSELqlLDTKKMLVIAPKQVAKDTWVDEVDKWnhlnh 81
Cdd:COG1061   78 SFELRPYQQEALEALLAalerGGGRGLVvAPTGTGKTVLALALAAEL--LRGKRVLVLVPRRELLEQWAEELRRF----- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  82 lkvslvLGTPKERNDALNTEADIYVT------NKENTKWLCDQykkewpFDMVVIDE---LStfkspkSQRFKSIKKKLP 152
Cdd:COG1061  151 ------LGDPLAGGGKKDSDAPITVAtyqslaRRAHLDELGDR------FGLVIIDEahhAG------APSYRRILEAFP 212

                        170
                 ....*....|..
gi 487709256 153 lINRFIGLTGTP 164
Cdd:COG1061  213 -AAYRLGLTATP 223
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 17-199 6.55e-08

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 53.35  E-value: 6.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  17 AIDKVIDNEKYGLFLD--MGLGKTVSTLTaFSELQLLDTK-----KMLVIAPKQVAKDtWVDEVDKW----NHLNHLKVS 85
Cdd:cd18068   19 SLKKTKKSPGSGCILAhcMGLGKTLQVVT-FLHTVLLCEKlenfsRVLVVCPLNTVLN-WLNEFEKWqeglKDEEKIEVN 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  86 LV--LGTPKERNDALNTEA----------DIY--------VTNKENTKWLCDQYKKEWPFDMVVIDELSTFKSPKSQRFK 145
Cdd:cd18068   97 ELatYKRPQERSYKLQRWQeeggvmiigyDMYrilaqernVKSREKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSK 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 487709256 146 SIKKKlpLINRFIGLTGTPSPNSLQDLWAQVYLIDrgERLESSFSRYRERYFKP 199
Cdd:cd18068  177 AMNSI--RTKRRIVLTGTPLQNNLIEYHCMVNFVK--PNLLGTIKEFRNRFVNP 226
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 24-199 1.75e-07

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 52.16  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  24 NEKYGLFL--DMGLGKTVSTLTAFSELQLLD-------TKKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKER 94
Cdd:cd18066   22 NERFGAILadEMGLGKTLQCISLIWTLLRQGpyggkpvIKRALIVTPGSLVKN-WKKEFQKWLGSERIKVFTVDQDHKVE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  95 NDALNTEADIYVTNKENTKWLCDQYKKeWPFDMVVIDELSTFKSpksqrfKSIKKKLPLIN----RFIGLTGTPSPNSLQ 170
Cdd:cd18066  101 EFIASPLYSVLIISYEMLLRSLDQISK-LNFDLVICDEGHRLKN------TSIKTTTALTSlsceRRIILTGTPIQNDLQ 173

                        170       180
                 ....*....|....*....|....*....
gi 487709256 171 DLWAQVYLIDRGerLESSFSRYRERYFKP 199
Cdd:cd18066  174 EFFALIDFVNPG--ILGSLSTYRKVYEEP 200
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 32-180 2.18e-07

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 51.17  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTV---STLTAFSELQLLDtKKMLVIAPKQVAKDtWVDEVDKW----------------NHLNHLKVSLVLgtpK 92
Cdd:cd18000   27 EMGLGKTIqiiAFLAALHHSKLGL-GPSLIVCPATVLKQ-WVKEFHRWwppfrvvvlhssgsgtGSEEKLGSIERK---S 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  93 ERNDALNTEADIYVTNKENTKWLCDQYKK-EWpfDMVVIDELSTFKSPKSQrFKSIKKKLPLINRFIgLTGTPSPNSLQD 171
Cdd:cd18000  102 QLIRKVVGDGGILITTYEGFRKHKDLLLNhNW--QYVILDEGHKIRNPDAE-ITLACKQLRTPHRLI-LSGTPIQNNLKE 177


                 ....*....
gi 487709256 172 LWAqvyLID 180
Cdd:cd18000  178 LWS---LFD 183
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 32-206 4.33e-07

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 50.58  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQllDTKKM----LVIAPKQVAKDtWVDEVDKWnhLNHLKVSLVLGTPKERN------------ 95
Cdd:cd18002   27 EMGLGKTVQSIAVLAHLA--EEHNIwgpfLVIAPASTLHN-WQQEISRF--VPQFKVLPYWGNPKDRKvlrkfwdrknly 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  96 --DA----LNTEADIYVTNK---ENTKWlcdQYkkewpfdmVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSP 166
Cdd:cd18002  102 trDApfhvVITSYQLVVQDEkyfQRVKW---QY--------MVLDEAQAIKSSSSSRWKTLLS-FHCRNRLL-LTGTPIQ 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 487709256 167 NSLQDLWAQVYLI-----DRGERLESSFSRYRERYFKPTHQVSEH 206
Cdd:cd18002  169 NSMAELWALLHFImptlfDSHDEFNEWFSKDIESHAENKTGLNEH 213
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 32-174 5.33e-07

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 50.46  E-value: 5.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQLLDTK-KMLVIAPKQVAkDTWVDEVDKWnhLNHLKVSLVLGTPKERND---ALNTEAD---- 103
Cdd:cd18009   30 EMGLGKTIQTIALLAHLRERGVWgPFLVIAPLSTL-PNWVNEFARF--TPSVPVLLYHGTKEERERlrkKIMKREGtlqd 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487709256 104 --IYVTNKE----NTKWLCDQYkkeWPFdmVVIDELSTFKSPKSQRFKSIKKkLPLINRFIgLTGTPSPNSLQDLWA 174
Cdd:cd18009  107 fpVVVTSYEiamrDRKALQHYA---WKY--LIVDEGHRLKNLNCRLIQELKT-FNSDNRLL-LTGTPLQNNLSELWS 176
ResIII pfam04851
Type III restriction enzyme, res subunit;
7-164 8.44e-07

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 48.82  E-value: 8.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256    7 DFKPHSYQKYAIDKVID---NEKYGLFLDM--GLGKT-VSTLTAFSELQLLDTKKMLVIAPKQVAKDTWVDEVDKWNHLN 80
Cdd:pfam04851   1 KLELRPYQIEAIENLLEsikNGQKRGLIVMatGSGKTlTAAKLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   81 HLKVSLVLGtpkERNDALNTEADIYVTN-----KENTKWLCDQYKKEwpFDMVVIDEL--STFKSpksqrFKSIKKKLPl 153
Cdd:pfam04851  81 VEIGEIISG---DKKDESVDDNKIVVTTiqslyKALELASLELLPDF--FDVIIIDEAhrSGASS-----YRNILEYFK- 149

                         170
                  ....*....|.
gi 487709256  154 INRFIGLTGTP 164
Cdd:pfam04851 150 PAFLLGLTATP 160
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 13-179 2.68e-06

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 48.12  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  13 YQKYAID---KVIDNEKYGLFLD-MGLGKTVSTLTAFSELQLL--DTKKMLVIAPKQVAKDtWVDEVDKWnhLNHLKVSL 86
Cdd:cd18003    4 YQHIGLDwlaTLYEKNLNGILADeMGLGKTIQTIALLAHLACEkgNWGPHLIVVPTSVMLN-WEMEFKRW--CPGFKILT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  87 VLGTPKERNdALNTEadiyvTNKENTKWLC---------DQY---KKEWPFdmVVIDELSTFKSPKSQRFKSikkklpLI 154
Cdd:cd18003   81 YYGSAKERK-LKRQG-----WMKPNSFHVCitsyqlvvqDHQvfkRKKWKY--LILDEAHNIKNFKSQRWQT------LL 146

                        170       180
                 ....*....|....*....|....*....
gi 487709256 155 N----RFIGLTGTPSPNSLQDLWAQVYLI 179
Cdd:cd18003  147 NfntqRRLLLTGTPLQNSLMELWSLMHFL 175
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 32-174 3.10e-06

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 48.13  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSelQLLDTKK----MLVIAPKQVAKDtWVDEVDKWnhLNHLKVSLVLGTPKERNDALNTEA----D 103
Cdd:cd17996   30 EMGLGKTIQTISLIT--YLMEKKKnngpYLVIVPLSTLSN-WVSEFEKW--APSVSKIVYKGTPDVRKKLQSQIRagkfN 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 104 IYVTNKE---NTKWLCDQYKkeWPFdmVVIDElstfkspkSQRFKSIKKKLPLI--------NRFIgLTGTPSPNSLQDL 172
Cdd:cd17996  105 VLLTTYEyiiKDKPLLSKIK--WKY--MIIDE--------GHRMKNAQSKLTQTlntyyharYRLL-LTGTPLQNNLPEL 171


                 ..
gi 487709256 173 WA 174
Cdd:cd17996  172 WA 173
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 32-174 8.95e-06

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 46.93  E-value: 8.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQLLDT--KKMLVIAPKQVAKDtWVDEVDKWnhLNHLKVSLVLGTPKER-----NDALNTEADI 104
Cdd:cd18065   42 EMGLGKTLQTIALLGYLKHYRNipGPHMVLVPKSTLHN-WMNEFKRW--VPSLRAVCLIGDKDARaafirDVMMPGEWDV 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487709256 105 YVTNKENTKWLCDQYKK-EWPFdmVVIDELSTFKSPKSqRFKSIKKKLPLINRFIgLTGTPSPNSLQDLWA 174
Cdd:cd18065  119 CVTSYEMVIKEKSVFKKfNWRY--LVIDEAHRIKNEKS-KLSEIVREFKTTNRLL-LTGTPLQNNLHELWA 185
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 10-164 1.92e-05

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 44.60  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  10 PHSYQKYAIDKVIDNE-KYGLFLDM--GLGKTvstLTAFSELQLLDTKKMLVIAPKQVAKDTWVDEVDKWNHLNHLKvsl 86
Cdd:cd17926    1 LRPYQEEALEAWLAHKnNRRGILVLptGSGKT---LTALALIAYLKELRTLIVVPTDALLDQWKERFEDFLGDSSIG--- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487709256  87 VLGTPKErndALNTEADIYVTNKENTKWLCDQYKKEWP-FDMVVIDELSTFKSPKSQRFKSIKKKlpliNRFIGLTGTP 164
Cdd:cd17926   75 LIGGGKK---KDFDDANVVVATYQSLSNLAEEEKDLFDqFGLLIVDEAHHLPAKTFSEILKELNA----KYRLGLTATP 146
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 32-174 2.75e-05

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 45.43  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQLLDT--KKMLVIAPKQVAKDtWVDEVDKWnhLNHLKVSLVLGTPKER-----NDALNTEADI 104
Cdd:cd18064   42 EMGLGKTLQTISLLGYMKHYRNipGPHMVLVPKSTLHN-WMAEFKRW--VPTLRAVCLIGDKDQRaafvrDVLLPGEWDV 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487709256 105 YVTNKENTKWLCDQYKK-EWPFdmVVIDELSTFKSPKSqRFKSIKKKLPLINRFIgLTGTPSPNSLQDLWA 174
Cdd:cd18064  119 CVTSYEMLIKEKSVFKKfNWRY--LVIDEAHRIKNEKS-KLSEIVREFKTTNRLL-LTGTPLQNNLHELWA 185
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 32-205 3.71e-05

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 45.00  E-value: 3.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSEL--QLLDTKKMLVIAPKQVAKdTWVDEVDKWNhlNHLKVSLVLGTPKERNDALNTEADIYVTNK 109
Cdd:cd18054   47 EMGLGKTIQTISFLSYLfhQHQLYGPFLLVVPLSTLT-SWQREFEIWA--PEINVVVYIGDLMSRNTIREYEWIHSQTKR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 110 ENTKWLCDQYKK-----------EWPFdmVVIDELSTFKSPKSQRFKSikkklpLI----NRFIGLTGTPSPNSLQDLWA 174
Cdd:cd18054  124 LKFNALITTYEIllkdktvlgsiNWAF--LGVDEAHRLKNDDSLLYKT------LIdfksNHRLLITGTPLQNSLKELWS 195

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 487709256 175 QVYLI-----DRGERLESSFSRYRERYFKPTHQVSE 205
Cdd:cd18054  196 LLHFImpekfEFWEDFEEDHGKGRENGYQSLHKVLE 231
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 32-202 1.11e-04

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 43.50  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQllDTKKM----LVIAPKQVAKdTWVDEVDKWnhLNHLKVSLVLGTPKERN------------ 95
Cdd:cd17993   28 EMGLGKTVQTISFLSYLF--HSQQQygpfLVVVPLSTMP-AWQREFAKW--APDMNVIVYLGDIKSRDtireyefyfsqt 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  96 -----DALNTEADIYVTNKE---NTKWlcdQYkkewpfdmVVIDELSTFKSPKSQRFKSIKK-KLPliNRFIgLTGTPSP 166
Cdd:cd17993  103 kklkfNVLLTTYEIILKDKAflgSIKW---QY--------LAVDEAHRLKNDESLLYEALKEfKTN--NRLL-ITGTPLQ 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 487709256 167 NSLQDLWAQVYLIDRG-----ERLESSFSRYRERYFKPTHQ 202
Cdd:cd17993  169 NSLKELWALLHFLMPGkfdiwEEFEEEHDEEQEKGIADLHK 209
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 32-231 2.90e-04

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 42.34  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSELQLLDTK-KMLVIAPKQVAKDtWVDEVDKWNHLNHL-----KVSLVLGTPKE---RNDALNTEA 102
Cdd:cd18058   27 EMGLGKTIQSITFLSEIFLMGIRgPFLIIAPLSTITN-WEREFRTWTEMNAIvyhgsQISRQMIQQYEmyyRDEQGNPLS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 103 DIY-----VTNKENTKWLCDQYKK-EWpfDMVVIDELSTFKSPKSQRFKSIkkKLPLINRFIGLTGTPSPNSLQDLWAQV 176
Cdd:cd18058  106 GIFkfqvvITTFEMILADCPELKKiNW--SCVIIDEAHRLKNRNCKLLEGL--KLMALEHKVLLTGTPLQNSVEELFSLL 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 487709256 177 ylidrgerlessfsryreRYFKPTHQVSEHIFKWELRDGSEEKIYKQIEDICLSM 231
Cdd:cd18058  182 ------------------NFLEPSQFPSETTFLEEFGDLKTEEQVKKLQSILKPM 218
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 20-174 4.19e-04

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 42.87  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   20 KVIDNEKYGLFLD-MGLGKTVSTLTAFSELQLLD--TKKMLVIAPKQVAKDtWVDEVDKWNHLnhLKVSLVLGTPKERND 96
Cdd:PLN03142  183 RLYENGINGILADeMGLGKTLQTISLLGYLHEYRgiTGPHMVVAPKSTLGN-WMNEIRRFCPV--LRAVKFHGNPEERAH 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256   97 ALNT-----EADIYVTN-----KENTKWlcdqykKEWPFDMVVIDELSTFKSPKSqRFKSIKKKLPLINRFIgLTGTPSP 166
Cdd:PLN03142  260 QREEllvagKFDVCVTSfemaiKEKTAL------KRFSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYRLL-ITGTPLQ 331


                  ....*...
gi 487709256  167 NSLQDLWA 174
Cdd:PLN03142  332 NNLHELWA 339
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 303-420 4.23e-04

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 40.15  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 303 VRLIHDKKLDKLEEIIEE--SQGQPILLF----------------YNFKH----------DKERILQRFKEattledsny 354
Cdd:cd18793    5 IEEVVSGKLEALLELLEElrEPGEKVLIFsqftdtldileealreRGIKYlrldgstsskERQKLVDRFNE--------- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487709256 355 kerwNSGDIKLLIAHPAsAGHGLNLQQGGHIIVwFGLTWSLELYQQANARLYRQGQNHTTIIHHIM 420
Cdd:cd18793   76 ----DPDIRVFLLSTKA-GGVGLNLTAANRVIL-YDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 33-205 4.45e-04

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 41.46  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  33 MGLGKTVSTLTAFSELQLLDTKK--MLVIAPKQVAKDtWVDEVDKWNHLNhlkVSLVLGTPKERNDALNTEadiYVTNKE 110
Cdd:cd17995   28 MGLGKTIQSIAFLEHLYQVEGIRgpFLVIAPLSTIPN-WQREFETWTDMN---VVVYHGSGESRQIIQQYE---MYFKDA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256 111 NTKWLCDQYK------------------KEWPFDMVVIDELSTFKSpKSQRFKSIKKKLPLINRFIgLTGTPSPNSLQDL 172
Cdd:cd17995  101 QGRKKKGVYKfdvlittyemviadaeelRKIPWRVVVVDEAHRLKN-RNSKLLQGLKKLTLEHKLL-LTGTPLQNNTEEL 178

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 487709256 173 WAQVYLIDRGERleSSFSRYRERY--FKPTHQVSE 205
Cdd:cd17995  179 WSLLNFLEPEKF--PSSEEFLEEFgdLKTAEQVEK 211
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 32-174 5.41e-04

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 41.31  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVS--TLTAFSELQ----------------------LLDTKKMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLV 87
Cdd:cd18072   28 DMGLGKTLTmiALILAQKNTqnrkeeekekalteweskkdstLVPSAGTLVVCPASLVHQ-WKNEVESRVASNKLRVCLY 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  88 LGTPKERNDALNTEADIYVTNKENTKWLCDQYKKEWPFDM--------VVIDELSTFKSPKSQRFKSIkKKLPLINRFIg 159
Cdd:cd18072  107 HGPNRERIGEVLRDYDIVITTYSLVAKEIPTYKEESRSSPlfriawarIILDEAHNIKNPKVQASIAV-CKLRAHARWA- 184

                        170
                 ....*....|....*
gi 487709256 160 LTGTPSPNSLQDLWA 174
Cdd:cd18072  185 LTGTPIQNNLLDMYS 199
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 32-225 3.18e-03

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 38.99  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  32 DMGLGKTVSTLTAFSEL--QLLDTK----KMLVIAPKQVAKDtWVDEVDKWNHLNHLKVSLVLGTPKE---------RND 96
Cdd:cd18067   32 EMGLGKTLQCITLMWTLlrQSPQCKpeidKAIVVSPSSLVKN-WANELGKWLGGRLQPLAIDGGSKKEidrklvqwaSQQ 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487709256  97 ALNTEADIYVTNKENTKWLCDQYKKeWPFDMVVIDELSTFKSPKSQRFKSIKKklplIN--RFIGLTGTPSPNSLQDLWA 174
Cdd:cd18067  111 GRRVSTPVLIISYETFRLHVEVLQK-GEVGLVICDEGHRLKNSDNQTYQALDS----LNtqRRVLLSGTPIQNDLSEYFS 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487709256 175 QVYLIDRGerLESSFSRYRERYFKPthqvsehIFKWELRDGSEEKIYKQIE 225
Cdd:cd18067  186 LVNFVNPG--ILGTAAEFKKNFELP-------ILKGRDADASEKERQLGEE 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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