staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
1-525
0e+00
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.
The actual alignment was detected with superfamily member NF035921:
Pssm-ID: 468263 [Multi-domain] Cd Length: 520 Bit Score: 882.24 E-value: 0e+00
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
1-525
0e+00
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.
Pssm-ID: 468263 [Multi-domain] Cd Length: 520 Bit Score: 882.24 E-value: 0e+00
Staphylococcus aureus coagulase; Staphylococcus aureus secretes a cofactor called coagulase. ...
29-307
9.22e-161
Staphylococcus aureus coagulase; Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages. The resulting complex directly initiates blood clotting.
Pssm-ID: 312335 Cd Length: 279 Bit Score: 463.08 E-value: 9.22e-161
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino ...
1-525
0e+00
staphylocoagulase; Past residue 485, the protein consists of a variable number of 27-amino acid tandem repeats (see PF04022). This HMM omits coverage of a portion of the repetitive C-terminal region.
Pssm-ID: 468263 [Multi-domain] Cd Length: 520 Bit Score: 882.24 E-value: 0e+00
Staphylococcus aureus coagulase; Staphylococcus aureus secretes a cofactor called coagulase. ...
29-307
9.22e-161
Staphylococcus aureus coagulase; Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages. The resulting complex directly initiates blood clotting.
Pssm-ID: 312335 Cd Length: 279 Bit Score: 463.08 E-value: 9.22e-161
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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