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Conserved domains on  [gi|486407075|ref|WP_001608759|]
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YncE family protein [Escherichia coli]

Protein Classification

YncE family protein( domain architecture ID 11465355)

YncE family protein contains repeats resembling the NHL (NCL-1, HT2A and LIN-41) and YVTN-type repeats, similar to DNA-binding beta-propeller protein YncE and Bacillus subtilis uncharacterized protein YwhL

CATH:  2.130.10.10
PubMed:  22120742|10607670
SCOP:  4002745

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
149-360 1.81e-15

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 75.12  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 149 LVFDPVTDRLFLPGLGLGIDSVLFVIDTRKRRLEKVLPGFRYNVVGITLDHQGRRVFVSNMQ-GQLFVVDPDTLSIIHCH 227
Cdd:COG3391   27 ALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGsGRVSVIDLATGKVVATI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 228 EVGADqLLNMVYDSRQNRLigvdqgidrrdwrnnhlgrdYIARSSGHEVFVLNADTAEIIARMSTDEIPIGLAWDDEQER 307
Cdd:COG3391  107 PVGGG-PRGLAVDPDGGRL--------------------YVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKR 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 486407075 308 LYVANRRGIRVDKgegTLTVFNTRNYTKVQTLQIPPHPNSLAFDAEKKYLFLT 360
Cdd:COG3391  166 LYVANSGSNTVSV---IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVA 215
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
47-221 6.67e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 67.80  E-value: 6.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  47 RVLRINPQTFSVEAEIALSAKGFGVALDDKRGLLYLTQGFNGSVAVVDISKNRLIATIPLmekvifeqryqqegitgtrl 126
Cdd:COG3391   91 RVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV-------------------- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 127 aflmgelsrfrvsEGYPWklrELVFDPVTDRLFLPGLGLG-IDSVLFVIDTRKRRLEKVLPgFRYNVVGITLDHQGRRVF 205
Cdd:COG3391  151 -------------GAGPH---GIAVDPDGKRLYVANSGSNtVSVIVSVIDTATGKVVATIP-VGGGPVGVAVSPDGRRLY 213
                        170       180
                 ....*....|....*....|....
gi 486407075 206 VSN--------MQGQLFVVDPDTL 221
Cdd:COG3391  214 VANrgsntsngGSNTVSVIDLATL 237
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
149-360 1.81e-15

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 75.12  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 149 LVFDPVTDRLFLPGLGLGIDSVLFVIDTRKRRLEKVLPGFRYNVVGITLDHQGRRVFVSNMQ-GQLFVVDPDTLSIIHCH 227
Cdd:COG3391   27 ALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGsGRVSVIDLATGKVVATI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 228 EVGADqLLNMVYDSRQNRLigvdqgidrrdwrnnhlgrdYIARSSGHEVFVLNADTAEIIARMSTDEIPIGLAWDDEQER 307
Cdd:COG3391  107 PVGGG-PRGLAVDPDGGRL--------------------YVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKR 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 486407075 308 LYVANRRGIRVDKgegTLTVFNTRNYTKVQTLQIPPHPNSLAFDAEKKYLFLT 360
Cdd:COG3391  166 LYVANSGSNTVSV---IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVA 215
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
47-221 6.67e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 67.80  E-value: 6.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  47 RVLRINPQTFSVEAEIALSAKGFGVALDDKRGLLYLTQGFNGSVAVVDISKNRLIATIPLmekvifeqryqqegitgtrl 126
Cdd:COG3391   91 RVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV-------------------- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 127 aflmgelsrfrvsEGYPWklrELVFDPVTDRLFLPGLGLG-IDSVLFVIDTRKRRLEKVLPgFRYNVVGITLDHQGRRVF 205
Cdd:COG3391  151 -------------GAGPH---GIAVDPDGKRLYVANSGSNtVSVIVSVIDTATGKVVATIP-VGGGPVGVAVSPDGRRLY 213
                        170       180
                 ....*....|....*....|....
gi 486407075 206 VSN--------MQGQLFVVDPDTL 221
Cdd:COG3391  214 VANrgsntsngGSNTVSVIDLATL 237
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
201-297 9.56e-04

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 41.07  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  201 GRRVFVSNMQGQLFVVDPDTLSIIHCHEVGADQLL----NMVYDSRQN-RLIGVDQGIDRRDWRNNHLGR---------- 265
Cdd:TIGR03300 241 GGQVYAVSYQGRVAALDLRSGRVLWKRDASSYQGPavddNRLYVTDADgVVVALDRRSGSELWKNDELKYrqltapavlg 320
                          90       100       110
                  ....*....|....*....|....*....|....
gi 486407075  266 DYIA--RSSGHeVFVLNADTAEIIARMSTDEIPI 297
Cdd:TIGR03300 321 GYLVvgDFEGY-LHWLDRDDGSFVARLKTDGSGI 353
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
276-358 6.32e-03

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 38.36  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  276 VFVLNADTAEIIARMSTDEI--PIGLAWDDEQERLYVANRRGI-------RVDKGEGTLTVFNtrnytKVQTLqiPPHPN 346
Cdd:pfam10282  17 VLTLDTETGALTLLGLVAEVgnPSYLALSPDGRTLYAVNEEGDqggvaafRIDPDSGALTLLN-----QVPTG--GASPC 89
                          90
                  ....*....|..
gi 486407075  347 SLAFDAEKKYLF 358
Cdd:pfam10282  90 HLSVDPDGRFLF 101
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
149-360 1.81e-15

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 75.12  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 149 LVFDPVTDRLFLPGLGLGIDSVLFVIDTRKRRLEKVLPGFRYNVVGITLDHQGRRVFVSNMQ-GQLFVVDPDTLSIIHCH 227
Cdd:COG3391   27 ALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGsGRVSVIDLATGKVVATI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 228 EVGADqLLNMVYDSRQNRLigvdqgidrrdwrnnhlgrdYIARSSGHEVFVLNADTAEIIARMSTDEIPIGLAWDDEQER 307
Cdd:COG3391  107 PVGGG-PRGLAVDPDGGRL--------------------YVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKR 165
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 486407075 308 LYVANRRGIRVDKgegTLTVFNTRNYTKVQTLQIPPHPNSLAFDAEKKYLFLT 360
Cdd:COG3391  166 LYVANSGSNTVSV---IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVA 215
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
168-332 2.85e-15

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 74.73  E-value: 2.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 168 DSVLFVIDTRKRRLEKVLPGFRyNVVGITLDHQGRRVFVSNMQ-GQLFVVDPDTLSIIHCHEVGaDQLLNMVYDSRQNRL 246
Cdd:COG3391   89 SGRVSVIDLATGKVVATIPVGG-GPRGLAVDPDGGRLYVADSGnGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDGKRL 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 247 igvdqgidrrdwrnnhlgrdYIARSSGHE----VFVLNADTAEIIARMSTDEIPIGLAWDDEQERLYVANRRGIRVDKGE 322
Cdd:COG3391  167 --------------------YVANSGSNTvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSNGGS 226
                        170
                 ....*....|
gi 486407075 323 GTLTVFNTRN 332
Cdd:COG3391  227 NTVSVIDLAT 236
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
47-221 6.67e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 67.80  E-value: 6.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  47 RVLRINPQTFSVEAEIALSAKGFGVALDDKRGLLYLTQGFNGSVAVVDISKNRLIATIPLmekvifeqryqqegitgtrl 126
Cdd:COG3391   91 RVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV-------------------- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 127 aflmgelsrfrvsEGYPWklrELVFDPVTDRLFLPGLGLG-IDSVLFVIDTRKRRLEKVLPgFRYNVVGITLDHQGRRVF 205
Cdd:COG3391  151 -------------GAGPH---GIAVDPDGKRLYVANSGSNtVSVIVSVIDTATGKVVATIP-VGGGPVGVAVSPDGRRLY 213
                        170       180
                 ....*....|....*....|....
gi 486407075 206 VSN--------MQGQLFVVDPDTL 221
Cdd:COG3391  214 VANrgsntsngGSNTVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
12-106 1.04e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  12 IQRIYPATTVVELVYSDMQQALFVSapdweDETLSRVLRINPQTFSVEAEIALSAKGFGVALDDKRGLLYLTQGFNGSVA 91
Cdd:COG3391  103 VATIPVGGGPRGLAVDPDGGRLYVA-----DSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVS 177
                         90
                 ....*....|....*....
gi 486407075  92 VV----DISKNRLIATIPL 106
Cdd:COG3391  178 VIvsviDTATGKVVATIPV 196
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
246-367 1.53e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 246 LIGVDQGIDRRDWRNNHLGRDYIARSSGHEVFVLNADTAEIIARMSTDEIPIGLAWDDEQERLYVANRRGirvdkgeGTL 325
Cdd:COG3391   20 ALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGS-------GRV 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 486407075 326 TVFNTRNYTKVQTLQIPPHPNSLAFDAEKKYLFLTVKNDETL 367
Cdd:COG3391   93 SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRV 134
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
201-297 9.56e-04

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 41.07  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  201 GRRVFVSNMQGQLFVVDPDTLSIIHCHEVGADQLL----NMVYDSRQN-RLIGVDQGIDRRDWRNNHLGR---------- 265
Cdd:TIGR03300 241 GGQVYAVSYQGRVAALDLRSGRVLWKRDASSYQGPavddNRLYVTDADgVVVALDRRSGSELWKNDELKYrqltapavlg 320
                          90       100       110
                  ....*....|....*....|....*....|....
gi 486407075  266 DYIA--RSSGHeVFVLNADTAEIIARMSTDEIPI 297
Cdd:TIGR03300 321 GYLVvgDFEGY-LHWLDRDDGSFVARLKTDGSGI 353
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
24-98 1.09e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  24 LVYSDMQQALFVSapDWEDETLSR-VLRINPQTFSVEAEIALSAKGFGVALDDKRGLLYLTQ-------GFNGSVAVVDI 95
Cdd:COG3391  157 IAVDPDGKRLYVA--NSGSNTVSViVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANrgsntsnGGSNTVSVIDL 234

                 ...
gi 486407075  96 SKN 98
Cdd:COG3391  235 ATL 237
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
201-315 1.19e-03

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 40.57  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 201 GRRVFVSNMQGQLFVVDPDTLSIIHCHEVGADQllNMVYDSrqNRLIGVDQ-----GIDRRD----WRNNHL-GR----- 265
Cdd:COG1520  233 GGVVYAVAYQGRLAALDLRSGRVLWSRDLSSYT--GLAVDG--NNLYVTDDdgrvwALDRRNgaelWKQDALlYRgltap 308
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 486407075 266 ----DYIA--RSSGHeVFVLNADTAEIIARMSTDEIPIG---LAWDDeqeRLYVANRRG 315
Cdd:COG1520  309 vvlgDYVVvgDFEGY-LHWLSRDDGSLVARLRVDGSGIRaapVVVGD---TLYVQTRDG 363
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
269-358 1.47e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 40.27  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075 269 ARSSGHEVFVLNADTAEIIARMSTDEI--PIGLAWDDEQERLYVANRRG------IRVDKGEGTLTVFNTrnytkVQTLq 340
Cdd:COG2706   18 GESEGIYVFRLDTATGELTLLGLVAALgnPSFLALSPDGRFLYAVNEVDdggvsaFRIDPADGTLTLLNT-----VSSG- 91
                         90
                 ....*....|....*...
gi 486407075 341 iPPHPNSLAFDAEKKYLF 358
Cdd:COG2706   92 -GASPCHLSVDPDGRFLF 108
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
276-358 6.32e-03

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 38.36  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486407075  276 VFVLNADTAEIIARMSTDEI--PIGLAWDDEQERLYVANRRGI-------RVDKGEGTLTVFNtrnytKVQTLqiPPHPN 346
Cdd:pfam10282  17 VLTLDTETGALTLLGLVAEVgnPSYLALSPDGRTLYAVNEEGDqggvaafRIDPDSGALTLLN-----QVPTG--GASPC 89
                          90
                  ....*....|..
gi 486407075  347 SLAFDAEKKYLF 358
Cdd:pfam10282  90 HLSVDPDGRFLF 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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