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Conserved domains on  [gi|486267076|ref|WP_001567357|]
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MULTISPECIES: ArsA-related P-loop ATPase [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
arsen_driv_ArsA super family cl37414
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 38-122 6.66e-43

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


The actual alignment was detected with superfamily member TIGR04291:

Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 147.93  E-value: 6.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   38 DPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKRIALTA 117
Cdd:TIGR04291 482 DPERTKVLLVTLPETTPVLEAARLQEDLRRAGIEPWWWVINNSLAATNTTSPLLSQRAQNELKWIEKVKRIHADRYAVIP 561


                  ....*
gi 486267076  118 LQSEE 122
Cdd:TIGR04291 562 LQAEE 566
 
Name Accession Description Interval E-value
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 38-122 6.66e-43

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 147.93  E-value: 6.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   38 DPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKRIALTA 117
Cdd:TIGR04291 482 DPERTKVLLVTLPETTPVLEAARLQEDLRRAGIEPWWWVINNSLAATNTTSPLLSQRAQNELKWIEKVKRIHADRYAVIP 561


                  ....*
gi 486267076  118 LQSEE 122
Cdd:TIGR04291 562 LQAEE 566
ArsA cd02035
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the ...
 37-133 2.74e-20

Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.


Pssm-ID: 349755 [Multi-domain]  Cd Length: 250  Bit Score: 82.94  E-value: 2.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  37 ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKRIALT 116
Cdd:cd02035  154 RDPERTTFVLVTIPEKLSIYETERLWGELQQYGIPVDGVVVNQVLPEEADDSFFLRRRRQQQKYLDEIEELFEPLPVVEV 233

                         90
                 ....*....|....*..
gi 486267076 117 ALQSEEPVGIDLLEDMA 133
Cdd:cd02035  234 PLLPEEVRGLEALRALA 250
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
37-134 7.01e-12

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 439774  Cd Length: 299  Bit Score: 60.60  E-value: 7.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  37 ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKR-IAL 115
Cdd:COG0003  198 RDPERTSFRLVTNPERLAIAETRRALEELALYGIPVDGLVVNRVLPEEADDDAFLAARRERQQEYLAEIEEAFAPLpVVE 277

                         90
                 ....*....|....*....
gi 486267076 116 TALQSEEPVGIDLLEDMAK 134
Cdd:COG0003  278 VPLLAEEVVGLEALRALAE 296
ArsA_ATPase pfam02374
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
 33-134 6.46e-08

Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.


Pssm-ID: 396792  Cd Length: 302  Bit Score: 49.66  E-value: 6.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   33 SEKAADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAA-QPSSPFLKIRANRELPLISDVEEQYA- 110
Cdd:pfam02374 195 REILTDPERTSFRLVCIPEKMSLYETERAIQYLAKYGIDVDAVIVNQVLPENvQENCPFCEARKKIQQKYLDEIEELFSd 274

                          90       100
                  ....*....|....*....|....
gi 486267076  111 KRIALTALQSEEPVGIDLLEDMAK 134
Cdd:pfam02374 275 FPVAKLPLLPEEVVGLEKLEKFSK 298
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 34-132 9.59e-07

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 46.41  E-value: 9.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  34 EKAADPEKTKVIIVTLAETTPVLEATNLQQDLR-RAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKR 112
Cdd:NF041417 511 ETMRDPERSTFVFVMYPEYTPMMEAWRAAEDLRnQVGIETSLVAVNYLLPEEYGNNAFFESRRKQQQKYLEEIRDRFDVP 590

                         90       100
                 ....*....|....*....|
gi 486267076 113 IALTALQSEEPVGIDLLEDM 132
Cdd:NF041417 591 MLLAPLQRDEPTGIEELRRF 610
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 26-133 1.06e-06

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 46.41  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  26 LTSKTGDSEKA----ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPL 101
Cdd:NF041417 177 LQEQKEDYEKAidtlQDDAQTSFVFVGKPEDASIDEIERSSKELADLGIKTSLLVINGYLPESVCEDPFFEMKREDEQEI 256

                         90       100       110
                 ....*....|....*....|....*....|...
gi 486267076 102 ISDVEEQYA-KRIALTALQSEEPVGIDLLEDMA 133
Cdd:NF041417 257 LEEVEREFAmQPIATYPLQPGEITGIDLLADVG 289
 
Name Accession Description Interval E-value
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 38-122 6.66e-43

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 147.93  E-value: 6.66e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   38 DPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKRIALTA 117
Cdd:TIGR04291 482 DPERTKVLLVTLPETTPVLEAARLQEDLRRAGIEPWWWVINNSLAATNTTSPLLSQRAQNELKWIEKVKRIHADRYAVIP 561


                  ....*
gi 486267076  118 LQSEE 122
Cdd:TIGR04291 562 LQAEE 566
ArsA cd02035
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the ...
 37-133 2.74e-20

Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.


Pssm-ID: 349755 [Multi-domain]  Cd Length: 250  Bit Score: 82.94  E-value: 2.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  37 ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKRIALT 116
Cdd:cd02035  154 RDPERTTFVLVTIPEKLSIYETERLWGELQQYGIPVDGVVVNQVLPEEADDSFFLRRRRQQQKYLDEIEELFEPLPVVEV 233

                         90
                 ....*....|....*..
gi 486267076 117 ALQSEEPVGIDLLEDMA 133
Cdd:cd02035  234 PLLPEEVRGLEALRALA 250
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
37-134 7.01e-12

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 439774  Cd Length: 299  Bit Score: 60.60  E-value: 7.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  37 ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKR-IAL 115
Cdd:COG0003  198 RDPERTSFRLVTNPERLAIAETRRALEELALYGIPVDGLVVNRVLPEEADDDAFLAARRERQQEYLAEIEEAFAPLpVVE 277

                         90
                 ....*....|....*....
gi 486267076 116 TALQSEEPVGIDLLEDMAK 134
Cdd:COG0003  278 VPLLAEEVVGLEALRALAE 296
ArsA_ATPase pfam02374
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
 33-134 6.46e-08

Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.


Pssm-ID: 396792  Cd Length: 302  Bit Score: 49.66  E-value: 6.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   33 SEKAADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAA-QPSSPFLKIRANRELPLISDVEEQYA- 110
Cdd:pfam02374 195 REILTDPERTSFRLVCIPEKMSLYETERAIQYLAKYGIDVDAVIVNQVLPENvQENCPFCEARKKIQQKYLDEIEELFSd 274

                          90       100
                  ....*....|....*....|....
gi 486267076  111 KRIALTALQSEEPVGIDLLEDMAK 134
Cdd:pfam02374 275 FPVAKLPLLPEEVVGLEKLEKFSK 298
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 34-132 9.59e-07

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 46.41  E-value: 9.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  34 EKAADPEKTKVIIVTLAETTPVLEATNLQQDLR-RAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPLISDVEEQYAKR 112
Cdd:NF041417 511 ETMRDPERSTFVFVMYPEYTPMMEAWRAAEDLRnQVGIETSLVAVNYLLPEEYGNNAFFESRRKQQQKYLEEIRDRFDVP 590

                         90       100
                 ....*....|....*....|
gi 486267076 113 IALTALQSEEPVGIDLLEDM 132
Cdd:NF041417 591 MLLAPLQRDEPTGIEELRRF 610
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 26-133 1.06e-06

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 46.41  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076  26 LTSKTGDSEKA----ADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLAAAQPSSPFLKIRANRELPL 101
Cdd:NF041417 177 LQEQKEDYEKAidtlQDDAQTSFVFVGKPEDASIDEIERSSKELADLGIKTSLLVINGYLPESVCEDPFFEMKREDEQEI 256

                         90       100       110
                 ....*....|....*....|....*....|...
gi 486267076 102 ISDVEEQYA-KRIALTALQSEEPVGIDLLEDMA 133
Cdd:NF041417 257 LEEVEREFAmQPIATYPLQPGEITGIDLLADVG 289
GET3_arsA_TRC40 TIGR00345
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that ...
 33-134 1.11e-05

transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see pfam02040) for As(III) efflux. [Hypothetical proteins, Conserved]


Pssm-ID: 273027 [Multi-domain]  Cd Length: 284  Bit Score: 43.23  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486267076   33 SEKAADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSLaAAQPSSPFLKIRANRELPLISDVEEQYA-K 111
Cdd:TIGR00345 181 REILSDPERTSFVLVVIPEKMSLYESERAHKELAKYGIKVDAVIVNQVL-PENAQDEFCQARWELQQKYLKQIPEKFAdL 259

                          90       100
                  ....*....|....*....|...
gi 486267076  112 RIALTALQSEEPVGIDLLEDMAK 134
Cdd:TIGR00345 260 PVAEVPLQKEEMVGLEALKRLSK 282
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 34-81 5.99e-03

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 35.45  E-value: 5.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 486267076   34 EKAADPEKTKVIIVTLAETTPVLEATNLQQDLRRAGIEPWAWVVNNSL 81
Cdd:TIGR04291 186 EALSDPERTRLILVARPQKSTLLEVARTHQELAAIGLKNQYLVINGVL 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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