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Conserved domains on  [gi|486153120|ref|WP_001518875|]
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MULTISPECIES: nucleotide exchange factor GrpE [Salmonella]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793376)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-196 1.23e-127

heat shock protein GrpE; Provisional


:

Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 357.06  E-value: 1.23e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRERDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-196 1.23e-127

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 357.06  E-value: 1.23e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRERDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-195 1.60e-57

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 177.65  E-value: 1.60e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  45 ANLEVQLAEAqtreRDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKaNPDMAAMVEGIE 124
Cdd:COG0576    2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 486153120 125 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKA 195
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 59-192 1.67e-56

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 174.62  E-value: 1.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  59 RDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKaNPDMAAMVEGIELTLKSMLDVVRKFG 138
Cdd:cd00446    4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 486153120 139 VEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTV 192
Cdd:cd00446   83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
32-194 9.72e-49

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 156.23  E-value: 9.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   32 DSAEQVDPRDEKIANLEVQLAEAQTRER---DTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEV 108
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  109 AdKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAA 188
Cdd:pfam01025  81 A-PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPA 159


                  ....*.
gi 486153120  189 MVTVAK 194
Cdd:pfam01025 160 MVVVSK 165
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-196 1.23e-127

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 357.06  E-value: 1.23e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRERDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK10325   1 MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK10325  81 EKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK10325 161 ESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-194 2.48e-92

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 267.56  E-value: 2.48e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDsAEQVDPRDEKIANLEVQLAEAQTRERDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK14150   1 MSNEEQKTPQEQVSEEIEAEVEQQEEADEAEL-EDELDEADARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAEQDV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 160
Cdd:PRK14150  80 EKAHKFALEKFANELLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQ 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14150 160 ESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-195 1.60e-57

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 177.65  E-value: 1.60e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  45 ANLEVQLAEAqtreRDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKaNPDMAAMVEGIE 124
Cdd:COG0576    2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 486153120 125 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKA 195
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 59-192 1.67e-56

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 174.62  E-value: 1.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  59 RDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKaNPDMAAMVEGIELTLKSMLDVVRKFG 138
Cdd:cd00446    4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 486153120 139 VEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTV 192
Cdd:cd00446   83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 20-195 4.81e-55

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 172.65  E-value: 4.81e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  20 DQHEEVEAVEPNDSAEQV-DPRDEKIANLEVQLAEAQtrerDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPV 98
Cdd:PRK14151   4 EQTLDLQAPEAAQAEAAAgDDLTARVQELEEQLAAAK----DQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  99 IDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGY 178
Cdd:PRK14151  80 VDSLERGLELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGY 159

                        170
                 ....*....|....*..
gi 486153120 179 TLNGRTIRAAMVTVAKA 195
Cdd:PRK14151 160 LLNGRLLRPAMVVVSKA 176
GrpE pfam01025
GrpE;
32-194 9.72e-49

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 156.23  E-value: 9.72e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   32 DSAEQVDPRDEKIANLEVQLAEAQTRER---DTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEV 108
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  109 AdKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAA 188
Cdd:pfam01025  81 A-PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPA 159


                  ....*.
gi 486153120  189 MVTVAK 194
Cdd:pfam01025 160 MVVVSK 165
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 5-196 7.71e-47

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 152.05  E-value: 7.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   5 EQKTPEGQAPEeiiMDQHEEVEAVEPNDSAEQVDPrdekIANLEVQLAEAQTRER---DTVLRIKAEMENLRRRTEQDIE 81
Cdd:PRK14139   2 ENTQQNPSEQE---AEEAGAAAQAAAAAAAAAEDA----APALEAELAEAEAKAAelqDSFLRAKAETENVRRRAQEDVA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  82 KAHKFALEKFVNELLPVIDSLDRALevADKaNPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVE 161
Cdd:PRK14139  75 KAHKFAIESFAESLLPVKDSLEAAL--ADE-SGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVP 151

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 486153120 162 SEEvPAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14139 152 AEQ-EPNTVVAVLQKGYTIADRVLRPALVTVAAPK 185
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-194 5.07e-39

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 132.05  E-value: 5.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKT--PEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRErdtvLRIKAEMENLRRRTEQ 78
Cdd:PRK14140   1 MEEKNEQVeeEVEETEVEEAVEDEVEEETVEEESEAELLDEEQAKIAELEAKLDELEERY----LRLQADFENYKRRIQK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  79 DIEKAHKFALEKFVNELLPVIDSLDRALEVADKaNPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA 158
Cdd:PRK14140  77 ENEAAEKYRAQSLASDLLPALDNFERALQIEAD-DEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVM 155

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 486153120 159 MVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14140 156 QDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 21-194 4.13e-38

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 130.23  E-value: 4.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  21 QHEEVEAVEPNDSAEQVDPRDEKIANLEVQ----LAEAQTRER-DTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNEL 95
Cdd:PRK14144  22 VENEILEEETDEESQHQEPALGHPSYTALEeqltLAEQKAHENwEKSVRALAELENVRRRMEREVANAHKYGVEKLISAL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  96 LPVIDSLDRALEVADKANPdmAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQ 175
Cdd:PRK14144 102 LPVVDSLEQALQLADKNSD--PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNSVITVFQ 179

                        170
                 ....*....|....*....
gi 486153120 176 KGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14144 180 KGYKLSDRVIRPARVIVST 198
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 12-194 1.16e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 126.20  E-value: 1.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  12 QAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLA--EAQTRER-DTVLRIKAEMENLRRRTEQDIEKAHKFAL 88
Cdd:PRK14158  10 QIAEALKAKAAKEAEAAQGKPEAAQPVAAADRIKELEEALAakEAEAAANwDKYLRERADLENYRKRVQKEKEELLKYGN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  89 EKFVNELLPVIDSLDRALEVADKANpdMAAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLDPNVHQAIAMVESEEVPA 167
Cdd:PRK14158  90 ESLILEILPAVDNMERALDHADEES--MSAIIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESAEQEP 167

                        170       180
                 ....*....|....*....|....*..
gi 486153120 168 GNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14158 168 NTVVAVFQKGYLLNERLLRPAMVSVAT 194
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 3-194 9.76e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 124.40  E-value: 9.76e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   3 SKEQKTPEGQAPEEIimdqhEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAqtreRDTVLRIKAEMENLRRRTEQDIEK 82
Cdd:PRK14141   4 EKNKNGNPADAARDA-----NNPVDREAKPYEMEDDPEPDPLEALKAENAEL----KDRMLRLAAEMENLRKRTQRDVAD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  83 AHKFALEKFVNELLPVIDSLDRAL-----EVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAI 157
Cdd:PRK14141  75 ARAYGIAGFARDMLSVSDNLRRALdaipaEARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAM 154

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 486153120 158 AMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14141 155 FEVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAK 191
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 2-194 1.76e-34

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 120.63  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   2 SSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIANLEvqlaEAQTRERDTVLRIKAEMENLRRRTEQDIE 81
Cdd:PRK14148   7 SNVEDKSLDIETAAQVETAQESASGALEELSVEEQLERAKDTIKELE----DSCDQFKDEALRAKAEMENIRKRAERDVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  82 KAHKFALEKFVNELLPVIDSLDRALEVADKANpDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVE 161
Cdd:PRK14148  83 NARKFGIEKFAKELLPVIDSIEQALKHEVKLE-EAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 486153120 162 SEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14148 162 NPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVK 194
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 19-194 8.56e-34

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 118.13  E-value: 8.56e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  19 MDQ-HEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTrerdTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLP 97
Cdd:PRK14147   1 MNQdHPEFDSEDLAQNPPETDPLKAEVESLRSEIALVKA----DALRERADLENQRKRIARDVEQARKFANEKLLGELLP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  98 VIDSLDRALEVAdkaNPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKG 177
Cdd:PRK14147  77 VFDSLDAGLTAA---GTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKG 153

                        170
                 ....*....|....*..
gi 486153120 178 YTLNGRTIRAAMVTVAK 194
Cdd:PRK14147 154 YLLNERLLRPALVVVAK 170
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 1-194 1.27e-29

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 108.04  E-value: 1.27e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEiiMDQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAqtreRDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK14149   4 EHNQEHDHLSQKEPES--EEKACACKEQQGEEKQEASEKEGEIKEDFELKYKEM----HEKYLRVHADFENVKKRLERDK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVAdKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMV 160
Cdd:PRK14149  78 SMALEYAYEKIALDLLPVIDALLGALKSA-AEVDKESALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQV 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14149 156 KSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 189
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 26-193 1.34e-29

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 108.51  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  26 EAVEPNDSAEQVDPRDEKIANLEVQLAEAqtreRDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRA 105
Cdd:PRK14155   4 EQTPAEDGPFEADDAAQEIEALKAEVAAL----KDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120 106 LEVA--DKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAET-NVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNG 182
Cdd:PRK14155  80 TAASpkDSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPAkGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMG 159

                        170
                 ....*....|.
gi 486153120 183 RTIRAAMVTVA 193
Cdd:PRK14155 160 RLVRPAMVAVA 170
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 15-194 3.54e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 101.84  E-value: 3.54e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  15 EEIIMDQHEEVEAVEPNDSAEQVDPRDEK----IANLEVQLAEAQTRE-RDTVLRIKAEMENLRRRTEQDIEKAHKFALE 89
Cdd:PRK14153   4 KEVGKDKAENSEARNSGSSAEEAEELKEEpedsTADSETEKCREEIESlKEQLFRLAAEFDNFRKRTAREMEENRKFVLE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  90 KFVNELLPVIDSLDRALEVADKANpDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGN 169
Cdd:PRK14153  84 QVLLDLLEVTDNFERALESARTAE-DMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNT 162

                        170       180
                 ....*....|....*....|....*
gi 486153120 170 VLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14153 163 IVDVCKPGYALNSKVIRPAMVSVAR 187
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 1-193 2.22e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 97.57  E-value: 2.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPE--EIIMDQHEEVEAVEPNDSAEQVDPRD-------EKIANLEVQLAEAQTRERDTVLRIKAEMEN 71
Cdd:PRK14154   5 MSSKNNPESETKAKNkwEKVMEAEEEQEEGGGDGSQEMEPHREglefpsrEKLEGQLTRMERKVDEYKTQYLRAQAEMDN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  72 LRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLD 150
Cdd:PRK14154  85 LRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVInPNPGDPFD 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 486153120 151 PNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14154 165 PALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 20-194 4.62e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 90.52  E-value: 4.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  20 DQHEEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRE-RDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPV 98
Cdd:PRK14159   3 EQKQEFENENAENSEHLQDENLQNIEDVEQNKLQKDYDElKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  99 IDSLDRALEVadKANPDMAAMV-EGIELTLKSMLDVVRKFGVEVIAETNvPLDPNVHQAIAMVESEEVPAGNVLGIMQKG 177
Cdd:PRK14159  83 LDALEAAVNV--ECHDEISLKIkEGVQNTLDLFLKKLEKHGVALIKEEK-EFDPNLHEAMFHVDSENHQSGEVVQVLQKG 159

                        170
                 ....*....|....*..
gi 486153120 178 YTLNGRTIRAAMVTVAK 194
Cdd:PRK14159 160 YKIADRVIRPTKVSVAK 176
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 1-196 1.23e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 88.25  E-value: 1.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHE--EVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTR------ERDTV----LRIKAE 68
Cdd:PRK14143  17 ESEAEDNSPESSEEVTEQEAELTnpEGDAAEAESSPDSGSAASETAADNAARLAQLEQEleslkqELEELnsqyMRIAAD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  69 MENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVP 148
Cdd:PRK14143  97 FDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVDVLKRLGVSPMRVVGQE 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 486153120 149 LDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14143 177 FDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGP 224
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 3-194 2.98e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 86.43  E-value: 2.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   3 SKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQvdPRDEKIANLEVQLAEAQTRER---DTVLRIKAEMENLRRRTEQD 79
Cdd:PRK14162   2 SKEEFPSEKDLPQEETTDEAPKKEAKEAPKEEDQ--EKQNPVEDLEKEIADLKAKNKdleDKYLRSQAEIQNMQNRYAKE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  80 IEKAHKFALEKFVNELLPVIDSLDRALEVadKANPDMAAMVE-GIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA 158
Cdd:PRK14162  80 RAQLIKYESQSLAKDVLPAMDNLERALAV--KADDEAAKQLKkGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQ 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 486153120 159 MVESE-EVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14162 158 TVAAEnDDQKDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 23-194 1.34e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 84.59  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  23 EEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQtRERDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSL 102
Cdd:PRK14145  30 EDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQ-EYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120 103 DRALEvadkANPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNG 182
Cdd:PRK14145 109 ERALA----SSGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVFQKGYYLKD 184

                        170
                 ....*....|..
gi 486153120 183 RTIRAAMVTVAK 194
Cdd:PRK14145 185 KVIRPSLVKVAK 196
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 9-196 3.20e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 84.02  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   9 PEGQAPEEIIMDQHEEVEAVEPNDSAEQvdprdekiANLEVQLAEAQTR--ERDTVL-RIKAEMENLRRRTEQDIEKAHK 85
Cdd:PRK14163  15 PSGATPDDAEPKAASEEGAAPAGDAAAT--------AGLTAQLDQVRTAlgERTADLqRLQAEYQNYRRRVERDRVTVKE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  86 FALEKFVNELLPVIDSLDRALEVADkanpdmaaMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESEEV 165
Cdd:PRK14163  87 IAVANLLSELLPVLDDVGRAREHGE--------LVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDV 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 486153120 166 PAGNVLGIMQKGYTLNGRTIRAAMVTVAKAK 196
Cdd:PRK14163 159 TETTCVAILQPGYRIGERTIRPARVAVAEPQ 189
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 1-194 1.73e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 82.11  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   1 MSSKEQKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKiANLEVQLAEAQtrerDTVLRIKAEMENLRRRTEQDI 80
Cdd:PRK14160  28 KGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDENNKLKEEN-KKLENELEALK----DRLLRTVAEYDNYRKRTAKEK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  81 EKAHKFALEKFVNELLPVIDSLDRALEVADKANPdmaaMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMV 160
Cdd:PRK14160 103 EGIYSDACEDVLKELLPVLDNLERAAAVEGSVED----LKKGIEMTVKQFKTSLEKLGVEEI-STEGEFDPNLHNAVMHV 177

                        170       180       190
                 ....*....|....*....|....*....|....
gi 486153120 161 ESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
Cdd:PRK14160 178 EDENYGENEIVEVFQKGYKRGDKVIRYSMVKVAN 211
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 31-194 8.48e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 76.94  E-value: 8.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  31 NDSAEQVDPRDE--KIANLEVQLAEAQTRE-RDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALE 107
Cdd:PRK14161   8 NNEQTINDIAEEivETANPEITALKAEIEElKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120 108 -VADKANPDMAAMVEGIELTLKSMLDVVRKFGVEVIA-ETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTI 185
Cdd:PRK14161  88 hKPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLL 167


                 ....*....
gi 486153120 186 RAAMVTVAK 194
Cdd:PRK14161 168 RPATVQVVK 176
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 6-193 1.85e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 76.76  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   6 QKTPEGQAPEEIIMDQHEEVEAVEPNDSAEQVDPRDEKIAnlEVQLAEAQTRERDTVL-RIKAEMENLRRRTEQDIEKAH 84
Cdd:PRK14164  38 QGVPEDDPFGDAVEGEIDPDLEADLEDLLDDVDPELADDG--EASTVEAQLAERTEDLqRVTAEYANYRRRTERERQAII 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  85 KFALEKFVNELLPVIDSLDRALEVADkanpdmaaMVEGielTLKSMLD----VVRKFGVEVIAETNVPLDPNVHQAIA-M 159
Cdd:PRK14164 116 ETAKAGVATDLLPILDDLDLAEQHGD--------LNEG---PLKAFSDkltnVLAGLKVEKFGEEGDAFDPEIHEAVQdL 184

                        170       180       190
                 ....*....|....*....|....*....|....
gi 486153120 160 VESEEVPAGNVLgimQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14164 185 SSGDEKVLGTVL---RKGYRMGDRVLRTAMVIIA 215
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 6-196 2.91e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 73.61  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   6 QKTPEGQAPEEIIMDQHEEVEAVEPNDSA-EQVDPRDEKIANLEVQLAEAQTR---ERDTVLRIKAEMENLRRRTEQDIE 81
Cdd:PRK14146  17 EKKSQSQTLEESKLENMNSEESQTITEETqEQAVEGAETETSLQKELDNAKKEiesLKDSWARERAEFQNFKRRSAQEFV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  82 KAHKFALEKFVNELLPVIDSLDRALEVADKAnPDMAAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVE 161
Cdd:PRK14146  97 SIRKEAVKSLVSGFLNPIDNLERVGATQNQS-EELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEE 175

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 486153120 162 SEEVPAGNVLGIMQKGYTL----NGRTIRAAMVTVAKAK 196
Cdd:PRK14146 176 GDQYSEETVIDVYQAGYYYkeneDKFTLRPARVRIGKPK 214
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 23-194 1.21e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 71.02  E-value: 1.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  23 EEVEAVEPNDSAEQVDPRDEKIANLEVQLAEAQTRErDTVLRIKAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSL 102
Cdd:PRK14156  12 EEVEATETEETVEEVVEETPEKSELELANERADEFE-NKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120 103 DRALEVADKANPdmaaMVEGIELTLKSMLDVVRKFGVEVIAETNvpLDPNVHQAIAMVES-EEVPAGNVLGIMQKGYTLN 181
Cdd:PRK14156  91 ERALAVEGLTDD----VKKGLEMVQESLIQALKEEGVEEVAVDS--FDHNLHMAVQTLPAdDEHPADSIAQVFQKGYKLH 164

                        170
                 ....*....|...
gi 486153120 182 GRTIRAAMVTVAK 194
Cdd:PRK14156 165 ERLLRPAMVVVYN 177
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 53-193 4.91e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 54.19  E-value: 4.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  53 EAQTRERdtvlrikAEMENLRRRTEQDIEKAHKFALEKFVNELLPVIDSLDRALEVADkANPDMAAMVEGIELTLKsmld 132
Cdd:PRK14157  98 EALQRER-------AEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDRIREHSE-MDDSFKAVAAKIDKAFE---- 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 486153120 133 vvrKFGVEVIAETNVPLDPNVHQAIAMVESEEVPAGNVLGIMQKGYTLNGRTIRAAMVTVA 193
Cdd:PRK14157 166 ---KFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 9-192 2.21e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 52.31  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120   9 PEGQAPEEI-IMDQHE------EVEAVEPNDSAEQVDP-----RDEKIANLEVQLAeaqtrerdtvlRIKAEMENLRRRT 76
Cdd:PRK14142   2 PDGNSGEQVtVTDKRRidpetgEVRHVPPGDMPGGTAAadaahTEDKVAELTADLQ-----------RVQADFANYRKRA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486153120  77 EQDIEKAHKFALEKFVNELLPVIDSLDRALEVADKANPDMAAMVEGIELTLKSMLDVVrkFGVEviaetNVPLDPNVHQA 156
Cdd:PRK14142  71 LRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSVADKLDSALTGLGLVA--FGAE-----GEDFDPVLHEA 143

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 486153120 157 IAMVESEEVPAGNVLG-IMQKGYTLNGRTIRAAMVTV 192
Cdd:PRK14142 144 VQHEGDGGQGSKPVIGtVMRQGYQLGEQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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