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Conserved domains on  [gi|486144581|ref|WP_001516917|]
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MULTISPECIES: DNA-binding transcriptional regulator CsiR [Escherichia]

Protein Classification

DNA-binding transcriptional regulator CsiR( domain architecture ID 11485384)

DNA-binding transcriptional regulator CsiR negatively regulates the expression of the glaH-lhgD-gabDTP operon in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 1-219 2.20e-150

DNA-binding transcriptional regulator CsiR; Provisional


:

Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 416.60  E-value: 2.20e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   1 MTITSLDGYRWLKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 80
Cdd:PRK11534   5 MQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  81 RANMEAMLVSLAIARGSDEWEADILAKAHLLGKLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 160
Cdd:PRK11534  85 RANMEAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 486144581 161 YRFIWLRQTVLSVEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMAG 219
Cdd:PRK11534 165 YRFIWLRRTVLSVEMLEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAG 223
 
Name Accession Description Interval E-value
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 1-219 2.20e-150

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 416.60  E-value: 2.20e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   1 MTITSLDGYRWLKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 80
Cdd:PRK11534   5 MQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  81 RANMEAMLVSLAIARGSDEWEADILAKAHLLGKLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 160
Cdd:PRK11534  85 RANMEAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 486144581 161 YRFIWLRQTVLSVEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMAG 219
Cdd:PRK11534 165 YRFIWLRRTVLSVEMLEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAG 223
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
9-218 8.57e-43

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 143.52  E-value: 8.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 88
Cdd:COG1802   17 YEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEGLA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  89 VSLAIARGSDEWEADILAKAHLLGKLEASDAseqmLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLRQ 168
Cdd:COG1802   97 ARLAAERATPADLARLRALLEELEAAAAAGD----VAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLRS 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 486144581 169 TvlsvEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMA 218
Cdd:COG1802  173 P----GRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 76-206 1.42e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 78.17  E-value: 1.42e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581    76 DIFDARANMEAMLVSLAIARGSDEweaDILAKAHLLGKLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLF 155
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDE---DLAALEALLDAMEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLR 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 486144581   156 DLAARYRFIwlrqtvlSVEMLEDKRDQHQILTDAVLARDTARASELMRQHL 206
Cdd:smart00895  78 ARLRRLRRL-------SLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 76-204 3.77e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 71.63  E-value: 3.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   76 DIFDARANMEAMLVSLAIARGSDEWEADILAKAHLLGKLEASDAseqmLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLF 155
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGD----LEAFAEADREFHLALAEAAGNPVLARMLESLW 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 486144581  156 DLAARYRFIWLRqtvlSVEMLEDKRDQHQILTDAVLARDTARASELMRQ 204
Cdd:pfam07729  77 DRLRRLRRLLLS----SPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-67 1.00e-08

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 50.14  E-value: 1.00e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKLR-MSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVA 67
Cdd:cd07377    7 ADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 1-219 2.20e-150

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 416.60  E-value: 2.20e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   1 MTITSLDGYRWLKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 80
Cdd:PRK11534   5 MQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  81 RANMEAMLVSLAIARGSDEWEADILAKAHLLGKLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 160
Cdd:PRK11534  85 RANMEAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAAR 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 486144581 161 YRFIWLRQTVLSVEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMAG 219
Cdd:PRK11534 165 YRFIWLRRTVLSVEMLEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAG 223
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
9-218 8.57e-43

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 143.52  E-value: 8.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 88
Cdd:COG1802   17 YEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEGLA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  89 VSLAIARGSDEWEADILAKAHLLGKLEASDAseqmLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYRFIWLRQ 168
Cdd:COG1802   97 ARLAAERATPADLARLRALLEELEAAAAAGD----VAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLRS 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 486144581 169 TvlsvEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMA 218
Cdd:COG1802  173 P----GRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-218 5.71e-23

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 92.30  E-value: 5.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKL---RMslLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELL---------- 75
Cdd:COG2186   13 AEQLRELILSGELKPGDRLpseRE--LAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLdplalllald 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  76 -----DIFDARANMEAMLVSLAIARGSDEweaDILAKAHLLGKLEASDASEQMLDEWDQRhqaFHTAIVAGCGSHYLLQM 150
Cdd:COG2186   91 daslrDLLEARLALEPEAARLAAERATDE---DLARLEAALAEMEAAADDGEAFAEADLA---FHRAIAEASGNPLLALL 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 486144581 151 RERLFDLAARYRfiwlRQTVLSVEMLEDKRDQHQILTDAVLARDTARASELMRQHLLTPIPIIQQAMA 218
Cdd:COG2186  165 LESLRELLRRSV----RLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALA 228
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 76-206 1.42e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 78.17  E-value: 1.42e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581    76 DIFDARANMEAMLVSLAIARGSDEweaDILAKAHLLGKLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLF 155
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDE---DLAALEALLDAMEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLR 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 486144581   156 DLAARYRFIwlrqtvlSVEMLEDKRDQHQILTDAVLARDTARASELMRQHL 206
Cdd:smart00895  78 ARLRRLRRL-------SLEAARRALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 76-204 3.77e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 71.63  E-value: 3.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   76 DIFDARANMEAMLVSLAIARGSDEWEADILAKAHLLGKLEASDAseqmLDEWDQRHQAFHTAIVAGCGSHYLLQMRERLF 155
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGD----LEAFAEADREFHLALAEAAGNPVLARMLESLW 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 486144581  156 DLAARYRFIWLRqtvlSVEMLEDKRDQHQILTDAVLARDTARASELMRQ 204
Cdd:pfam07729  77 DRLRRLRRLLLS----SPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-66 3.82e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 59.13  E-value: 3.82e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 486144581     9 YRWLKNDIIRGHFQPDEKLR-MSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRV 66
Cdd:smart00345   2 AERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-67 1.00e-08

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 50.14  E-value: 1.00e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKLR-MSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVA 67
Cdd:cd07377    7 ADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 9-66 1.83e-08

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 49.54  E-value: 1.83e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 486144581    9 YRWLKNDIIRGHFQPDEKL-RMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRV 66
Cdd:pfam00392   6 YARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 12-206 8.28e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.32  E-value: 8.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  12 LKNDIIRGHFQPDEKL---RMslLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVA-------------------SM 69
Cdd:PRK03837  22 LEQMIRSGEFGPGDQLpseRE--LMAFFGVGRPAVREALQALKRKGLVQISHGERARVSrpsadtiigqlsgmakdflSQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  70 SEQELLDIFDARANMEAMLVSLAIARGSDEWEADiLAKAhllgkLEASDASEQMLDEWDQRHQAFHTAIVAGCGSHYLLQ 149
Cdd:PRK03837 100 SPDGLAHLKQARLFFESSLARYAAEHATDEQIAL-LRKA-----LERNSQSLGDNAAFIRSDMEFHRVIAEIPGNPIFMA 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 486144581 150 MRERLFDLAARYRFIWLRQTVLSVEMLEdkrdQHQILTDAVLARDTARASELMRQHL 206
Cdd:PRK03837 174 IHEALLDWLIEARPEVVILHGHENVTLQ----EHIAIVDAIRAHDPDEADRALQSHL 226
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-87 2.24e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 41.00  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581   9 YRWLKNDIIRGHFQPDEKL-RMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVAS-MSEQELLDIFDARANMEA 86
Cdd:COG2188   11 ADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSRLTSFTEELRA 90


                 .
gi 486144581  87 M 87
Cdd:COG2188   91 R 91
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-206 5.47e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.75  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  23 PDEK-LRMSLLTSRYSLgvgplREALSQLVAERLVTVVNQKG----YRVASMSEQELL---------------DIFDARA 82
Cdd:PRK10421  27 PAERqLAMQLGVSRNSL-----REALAKLVSEGVLLSRRGGGtfirWRHETWSEQNIVqplktlmaddpdysfDILEARH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  83 NMEAMLVSLAIARGSDEweadilAKAHLLGKLEASDAseqmlDEWDQRHQA---FHTAIVAGCGSHYLLQMRERLFDLAa 159
Cdd:PRK10421 102 AIEASTAWHAAMRATPG------DKEKIQLCFEATLS-----EDPDLASQAdvrFHLAIAEASHNVVLLQTMRGFFDVL- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 486144581 160 RYRFIWLRQTVLSVEMLEDK-RDQHQILTDAVLARDTARASELMRQHL 206
Cdd:PRK10421 170 QSSVKQSRQRMYLVPPVFSQlTEQHQAVMDAILAGDAEGARKAMMAHL 217
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 43-206 1.57e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 38.59  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  43 LREALSQLVAERLVTVVNQKGYRVASMSEQE---------------LLDIFDARANMEAMLVSLAIARGSDeweADILAK 107
Cdd:PRK09990  48 LREGLTVLRGRGIIETAQGRGSFVARLNRVQdasplmhlfssqprtLYDLLEVRALLEGESARLAALRGTQ---ADFVLI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581 108 AHLLGKLEASDASEQMLD--EWDQRHQAFHTAIVAGCGSHYLLQMRERLFDLAaryrfiwLRQTVLSVEML----EDKR- 180
Cdd:PRK09990 125 TRRYEEMLAAHENNKEIDpiEHARLDHAFHLAICEASHNPVLVHTLQSLTDLM-------LSSVFASVNNLyhrpQQKKq 197

                        170       180
                 ....*....|....*....|....*...
gi 486144581 181 --DQHQILTDAVLARDTARASELMRQHL 206
Cdd:PRK09990 198 idRQHARLYNAVLQRLPEQAQRAARDHI 225
PRK11414 PRK11414
GntR family transcriptional regulator;
12-123 2.00e-03

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 37.93  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 486144581  12 LKNDIIRGHFQPDEKLRMSLLTSRYSLGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSL 91
Cdd:PRK11414  20 LKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVAL 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 486144581  92 AIARGSDEWEADILAkahLLGKLEASDASEQM 123
Cdd:PRK11414 100 AVENLTPQDLAELQE---LLEKLQQAQEKGDM 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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