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Conserved domains on  [gi|481041842|ref|WP_001296218|]
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MULTISPECIES: TerC family protein [Enterobacteriaceae]

Protein Classification

TerC family protein( domain architecture ID 11436733)

TerC family inner membrane protein similar to Escherichia coli YoaE and YegH, which contain a TerC domain, tandem repeats of the cystathionine beta-synthase (CBS pair) domain, and a transporter-associated domain

Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 145-524 2.47e-84

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


:

Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 267.76  E-value: 2.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 145 ITAVGMVdhLLVMMAAVVIAISLMLMASKPLTQFVnSHPTIVILclSFLLMIGFSLVaegFGFVIPKGY--LYA---AIG 219
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAAL-AHTLALVL--AVVLITFLSLV---FGELVPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 220 FSVMIEALNQLA-----IFNRrrflsanqtlrqrTTEAVMRLLsGQKEDAELDAETA---SMLVDHGNQQ-IFNPQERRM 290
Cdd:COG1253  139 VAPPLRLFSRLFrplvwLLNG-------------STNLLLRLL-GIEPAEEEPAVTEeelRALVEESEESgVIEEEEREM 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 291 IERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaEDLLGVVHVIDLLQQSLRGEPLNLRV 370
Cdd:COG1253  205 IENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDL-DDIVGVVHVKDLLRALLEGEPFDLRD 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 371 LIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDArhDIQKNADGSWTANG 450
Cdd:COG1253  284 LLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEYDEEEP--EIVKLDDGSYLVDG 361

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041842 451 HMPLEDLVQYVPLPLDEKREYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEME 524
Cdd:COG1253  362 RLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 2.60e-60

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


:

Pssm-ID: 440622  Cd Length: 225  Bit Score: 198.35  E-value: 2.60e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   1 MEWIAD-PSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQplfsfr 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842  80 sftfsardlIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMA 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 481041842 160 AVVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMieALNQLAIFNRRR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRR 221
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 145-524 2.47e-84

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 267.76  E-value: 2.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 145 ITAVGMVdhLLVMMAAVVIAISLMLMASKPLTQFVnSHPTIVILclSFLLMIGFSLVaegFGFVIPKGY--LYA---AIG 219
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAAL-AHTLALVL--AVVLITFLSLV---FGELVPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 220 FSVMIEALNQLA-----IFNRrrflsanqtlrqrTTEAVMRLLsGQKEDAELDAETA---SMLVDHGNQQ-IFNPQERRM 290
Cdd:COG1253  139 VAPPLRLFSRLFrplvwLLNG-------------STNLLLRLL-GIEPAEEEPAVTEeelRALVEESEESgVIEEEEREM 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 291 IERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaEDLLGVVHVIDLLQQSLRGEPLNLRV 370
Cdd:COG1253  205 IENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDL-DDIVGVVHVKDLLRALLEGEPFDLRD 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 371 LIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDArhDIQKNADGSWTANG 450
Cdd:COG1253  284 LLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEYDEEEP--EIVKLDDGSYLVDG 361

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041842 451 HMPLEDLVQYVPLPLDEKREYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEME 524
Cdd:COG1253  362 RLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 2.60e-60

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 198.35  E-value: 2.60e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   1 MEWIAD-PSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQplfsfr 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842  80 sftfsardlIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMA 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 481041842 160 AVVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMieALNQLAIFNRRR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRR 221
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 14-204 1.94e-43

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 152.24  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   14 ITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLtqplfsfrsftfsaRDLIMLFG 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLEL--------------FDWLLLIG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   94 GFFLLFKATMELNE-RLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAAVVIAISLMLMAS 172
Cdd:pfam03741  67 GLFLLYTAIKLLRDlRKLVREEDKKLPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146

                         170       180       190
                  ....*....|....*....|....*....|..
gi 481041842  173 KPLTQFVNSHPTIVILCLSFLLMIGFSLVAEG 204
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 301-419 3.78e-38

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 135.70  E-value: 3.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 301 TVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDdAEDLLGVVHVIDLLQQSLRG-EPLNLRVLIRQPLVFP 379
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGD-LDNIIGVLHVKDLLAALLEGrEKLDLRALLRPPLFVP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 481041842 380 ETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTE 419
Cdd:cd04590   80 ETTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDILE 119
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
276-516 4.22e-29

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 116.45  E-value: 4.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 276 DHGNQQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDgDDAEDLLGVVHVID 355
Cdd:PRK15094  43 DSEQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVIS-EDKDHIEGILMAKD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 356 LLQQSLRG-EPLNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDA 434
Cdd:PRK15094 122 LLPFMRSDaEAFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDD 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 435 RhDIQKNADGSWTANGHMPLEDLVQYVPLPLDEKrEYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQI 514
Cdd:PRK15094 202 I-DFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHV 279


                 ...
gi 481041842 515 -IP 516
Cdd:PRK15094 280 kIP 282
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-517 5.11e-19

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 81.33  E-value: 5.11e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 481041842   439 QKNADGSWTANGHMPLEDLVQYVPLPLDEKrEYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPL 517
Cdd:smart01091   1 VKLDDGSYLVDGRTPIDDLNELLGLDLPEE-EYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTRP 78
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-518 4.33e-18

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 78.74  E-value: 4.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842  439 QKNADGSWTANGHMPLEDLVQYVPLPLDEkREYHTIAGLLMEYLQRIPKPGE--EVQVGDYLLKTLQVESHRVQKVQIIP 516
Cdd:pfam03471   1 EKLDDGSYLVDGRAPLDDLNELLGLELPE-EDYDTLGGLVLERLGRIPKVGDkvEVELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 481041842  517 LR 518
Cdd:pfam03471  80 LE 81
R_switched_YkoY TIGR03716
integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element ...
 17-179 5.53e-11

integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains proteins YceF and YkoY from Bacillus subtilis. A transport function is proposed.


Pssm-ID: 274742  Cd Length: 215  Bit Score: 62.29  E-value: 5.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   17 IVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQplfsfrsftfsardlIMLFGGFF 96
Cdd:TIGR03716   1 VILEGLLSADNALVLAVMVKHLPEKQRKKALFYGLIGAYVFRFIALFLASFLIKFWW---------------IKAIGALY 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   97 LLFKATMELNERLEGKDSNNPTQRK-GAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAAVVIAISLMLMASkpl 175
Cdd:TIGR03716  66 LLYLAIKHFRKKKKGKEDEEAEKKKaHSGFWRTVLKVELMDIAFSVDSILAAVALSGQFWVVFLGGIIGILIMRFAA--- 142


                  ....
gi 481041842  176 TQFV 179
Cdd:TIGR03716 143 TIFV 146
 
Name Accession Description Interval E-value
TlyC COG1253
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ...
 145-524 2.47e-84

Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];


Pssm-ID: 440865 [Multi-domain]  Cd Length: 435  Bit Score: 267.76  E-value: 2.47e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 145 ITAVGMVdhLLVMMAAVVIAISLMLMASKPLTQFVnSHPTIVILclSFLLMIGFSLVaegFGFVIPKGY--LYA---AIG 219
Cdd:COG1253   67 ITLAGLL--AGALGEAALAALLAPLLGSLGLPAAL-AHTLALVL--AVVLITFLSLV---FGELVPKRLalQNPervALL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 220 FSVMIEALNQLA-----IFNRrrflsanqtlrqrTTEAVMRLLsGQKEDAELDAETA---SMLVDHGNQQ-IFNPQERRM 290
Cdd:COG1253  139 VAPPLRLFSRLFrplvwLLNG-------------STNLLLRLL-GIEPAEEEPAVTEeelRALVEESEESgVIEEEEREM 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 291 IERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaEDLLGVVHVIDLLQQSLRGEPLNLRV 370
Cdd:COG1253  205 IENVFEFGDRTVREVMTPRTDVVALDLDDTLEEALELILESGHSRIPVYEGDL-DDIVGVVHVKDLLRALLEGEPFDLRD 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 371 LIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDArhDIQKNADGSWTANG 450
Cdd:COG1253  284 LLRPPLFVPETKPLDDLLEEFRRERVHMAIVVDEYGGTAGLVTLEDILEEIVGEIRDEYDEEEP--EIVKLDDGSYLVDG 361

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041842 451 HMPLEDLVQYVPLPLDEKREYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEME 524
Cdd:COG1253  362 RLPIDELNELLGLDLPEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDKVLVTRLPEEEEEE 435
TerC COG0861
Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];
1-237 2.60e-60

Tellurite resistance membrane protein TerC [Inorganic ion transport and metabolism];


Pssm-ID: 440622  Cd Length: 225  Bit Score: 198.35  E-value: 2.60e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   1 MEWIAD-PSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQplfsfr 79
Cdd:COG0861    1 MDLLLFgPEAWLALLTLYLLEIVLSIDNAFVIALIFRKLPPEQQKKALFWGILGALVLRIILIFLGAWLLSFPW------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842  80 sftfsardlIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMA 159
Cdd:COG0861   75 ---------ILYLGGLFLLWTAIKLLHEKEEEDEENENGKRAATPLWLAVVQIELADLVFSLDSVPAAFGITQDPFLVFT 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 481041842 160 AVVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMieALNQLAIFNRRR 237
Cdd:COG0861  146 GNIFAILGLRFLAFLLAGLLDRFPYLKYLAAAILGFIGVKLILEDLHFHIPKGYISLAVIFSVL--ALGILASLLKRR 221
CorB COG4536
Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion ...
 286-518 1.01e-55

Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains [Inorganic ion transport and metabolism];


Pssm-ID: 443602 [Multi-domain]  Cd Length: 420  Bit Score: 192.21  E-value: 1.01e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 286 QERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaEDLLGVVHVIDLLQQSLRGEP 365
Cdd:COG4536  190 EHRDMLLNILDLEDVTVEDIMVPRNEIEGIDLDDPWEEILKQLLTSPHTRLPVYRGDI-DNIVGVLHVRDLLRALRKGDL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 366 --LNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDarHDIQKNAD 443
Cdd:COG4536  269 skEDLRKIAREPYFIPETTPLSTQLQNFQKRKRRFALVVDEYGDVQGLVTLEDILEEIVGEITDEHDPDA--EEIRPQED 346

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 481041842 444 GSWTANGHMPLEDLVQY--VPLPLDekrEYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLR 518
Cdd:COG4536  347 GSYLVDGSATIRDLNRAldWNLPDD---GAKTLNGLIIEELEDIPEAGQSFTIHGYRFEILQVQDNRIKTVRIRPLP 420
TerC pfam03741
Integral membrane protein TerC family; This family contains a number of integral membrane ...
 14-204 1.94e-43

Integral membrane protein TerC family; This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.


Pssm-ID: 461035  Cd Length: 178  Bit Score: 152.24  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   14 ITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLtqplfsfrsftfsaRDLIMLFG 93
Cdd:pfam03741   1 FTLVLIEIVLSVDNAFVIALIFRKLPPEQQRKALFWGIGGALVLRILLIFLGVALLEL--------------FDWLLLIG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   94 GFFLLFKATMELNE-RLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAAVVIAISLMLMAS 172
Cdd:pfam03741  67 GLFLLYTAIKLLRDlRKLVREEDKKLPVTSSSLWLAVIQIELADLVFSLDSVPAAVGITDDPFIVITGNVFSILGLRFLS 146

                         170       180       190
                  ....*....|....*....|....*....|..
gi 481041842  173 KPLTQFVNSHPTIVILCLSFLLMIGFSLVAEG 204
Cdd:pfam03741 147 FLLAKLIERFPYLKYLAAAILGFIGVKLLLEG 178
CBS_pair_CorC_HlyC_assoc cd04590
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which ...
 301-419 3.78e-38

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in magnesium and cobalt efflux, and in association with some proteins of unknown function. The function of the CorC_HlyC domain is uncertain but it might be involved in modulating transport of ion substrates. These CBS domains are found in highly conserved proteins that either have unknown function or are puported to be hemolysins, exotoxins involved in lysis of red blood cells in vitro. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341366 [Multi-domain]  Cd Length: 119  Bit Score: 135.70  E-value: 3.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 301 TVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDdAEDLLGVVHVIDLLQQSLRG-EPLNLRVLIRQPLVFP 379
Cdd:cd04590    1 TVREVMTPRTDVVALDADATLEELLELILESGYSRFPVYEGD-LDNIIGVLHVKDLLAALLEGrEKLDLRALLRPPLFVP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 481041842 380 ETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTE 419
Cdd:cd04590   80 ETTPLDDLLEEFRKERSHMAIVVDEYGGTAGIVTLEDILE 119
PRK15094 PRK15094
magnesium/cobalt transporter CorC;
276-516 4.22e-29

magnesium/cobalt transporter CorC;


Pssm-ID: 185050 [Multi-domain]  Cd Length: 292  Bit Score: 116.45  E-value: 4.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 276 DHGNQQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDgDDAEDLLGVVHVID 355
Cdd:PRK15094  43 DSEQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVIS-EDKDHIEGILMAKD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 356 LLQQSLRG-EPLNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDA 434
Cdd:PRK15094 122 LLPFMRSDaEAFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDD 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 435 RhDIQKNADGSWTANGHMPLEDLVQYVPLPLDEKrEYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQI 514
Cdd:PRK15094 202 I-DFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHV 279


                 ...
gi 481041842 515 -IP 516
Cdd:PRK15094 280 kIP 282
PRK11573 PRK11573
hypothetical protein; Provisional
 245-518 5.51e-22

hypothetical protein; Provisional


Pssm-ID: 236933 [Multi-domain]  Cd Length: 413  Bit Score: 98.28  E-value: 5.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 245 LRQRTTEAVMRLLSGQKEDAELDA---ETASMLVDHGNQQIfNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAPE 321
Cdd:PRK11573 130 LLNTITRLLMRLMGIKTDIVVSGAlskEELRTIVHESRSQI-SRRNQDMLLSVLDLEKVTVDDIMVPRNEIVGIDINDDW 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 322 DEIRQLLERNQHTRLVVTDgDDAEDLLGVVHVIDLLQQSLRGEPLNLRVLIR---QPLVFPETLPLLPALEQFRNARTHF 398
Cdd:PRK11573 209 KSILRQLTHSPHGRIVLYR-DSLDDAISMLRVREAYRLMTEKKEFTKENMLRaadEIYFVPEGTPLSTQLVKFQRNKKKV 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 399 AFVVDEFGSVEGIVTLSDVTETIAGNL-----PNEVEEIDARhdiqknADGSWTANGHMPLEDLVQYV--PLPLDEKRey 471
Cdd:PRK11573 288 GLVVDEYGDIQGLVTVEDILEEIVGDFttsmsPTLAEEVTPQ------NDGSVIIDGTANVREINKAFnwHLPEDDAR-- 359

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 481041842 472 hTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLR 518
Cdd:PRK11573 360 -TVNGVILEALEEIPVAGTRVRIGEYDIDILDVQDNMIKQVKVTPVK 405
CorC_HlyC smart01091
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-517 5.11e-19

Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 215020 [Multi-domain]  Cd Length: 78  Bit Score: 81.33  E-value: 5.11e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 481041842   439 QKNADGSWTANGHMPLEDLVQYVPLPLDEKrEYHTIAGLLMEYLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPL 517
Cdd:smart01091   1 VKLDDGSYLVDGRTPIDDLNELLGLDLPEE-EYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTRP 78
CorC_HlyC pfam03471
Transporter associated domain; This small domain is found in a family of proteins with the ...
 439-518 4.33e-18

Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.


Pssm-ID: 460935 [Multi-domain]  Cd Length: 81  Bit Score: 78.74  E-value: 4.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842  439 QKNADGSWTANGHMPLEDLVQYVPLPLDEkREYHTIAGLLMEYLQRIPKPGE--EVQVGDYLLKTLQVESHRVQKVQIIP 516
Cdd:pfam03471   1 EKLDDGSYLVDGRAPLDDLNELLGLELPE-EDYDTLGGLVLERLGRIPKVGDkvEVELGGLRFTVLEMDGRRIKKVRITK 79


                  ..
gi 481041842  517 LR 518
Cdd:pfam03471  80 LE 81
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 309-417 4.52e-11

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 59.95  E-value: 4.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 309 RHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQQSL-RGEPLNLRV---LIRQPLVFPETLPL 384
Cdd:cd02205    1 TRDVVTVDPDTTVREALELMAENGIGALPVVDDDG--KLVGIVTERDILRALVeGGLALDTPVaevMTPDVITVSPDTDL 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 481041842 385 LPALEQFRNARTHFAFVVDEFGSVEGIVTLSDV 417
Cdd:cd02205   79 EEALELMLEHGIRRLPVVDDDGKLVGIVTRRDI 111
R_switched_YkoY TIGR03716
integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element ...
 17-179 5.53e-11

integral membrane protein, YkoY family; Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains proteins YceF and YkoY from Bacillus subtilis. A transport function is proposed.


Pssm-ID: 274742  Cd Length: 215  Bit Score: 62.29  E-value: 5.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   17 IVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQplfsfrsftfsardlIMLFGGFF 96
Cdd:TIGR03716   1 VILEGLLSADNALVLAVMVKHLPEKQRKKALFYGLIGAYVFRFIALFLASFLIKFWW---------------IKAIGALY 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842   97 LLFKATMELNERLEGKDSNNPTQRK-GAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAAVVIAISLMLMASkpl 175
Cdd:TIGR03716  66 LLYLAIKHFRKKKKGKEDEEAEKKKaHSGFWRTVLKVELMDIAFSVDSILAAVALSGQFWVVFLGGIIGILIMRFAA--- 142


                  ....
gi 481041842  176 TQFV 179
Cdd:TIGR03716 143 TIFV 146
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
301-428 8.40e-11

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 59.88  E-value: 8.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 301 TVSSIMTSrhDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQQSLRGEPLNLR----------V 370
Cdd:COG3448    3 TVRDIMTR--DVVTVSPDTTLREALELMREHGIRGLPVVDEDG--RLVGIVTERDLLRALLPDRLDELEerlldlpvedV 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481041842 371 LIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNE 428
Cdd:COG3448   79 MTRPVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALARLLEEE 136
COG2524 COG2524
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];
217-421 4.68e-09

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];


Pssm-ID: 442013 [Multi-domain]  Cd Length: 206  Bit Score: 56.43  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 217 AIGFSVMIEALNQLAIFNRRRFLSANQTLRQRTTEAVMRLLSGQKEDAELDAETASMLVDHGNQQIFNPQERRMIERVLN 296
Cdd:COG2524    3 VLLLLALSLLLPLLAVVLAALLLLAALVLALTAAAAATVLLLAAAAAAAGAGGLGLLLLLLLIVLQAAAVRVVAEKELGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 297 LNQRTVSSIMTSrhDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaedLLGVVHVIDLLQQSLRGEPL-NLRV---LI 372
Cdd:COG2524   83 VLKMKVKDIMTK--DVITVSPDTTLEEALELMLEKGISGLPVVDDGK---LVGIITERDLLKALAEGRDLlDAPVsdiMT 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 481041842 373 RQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETI 421
Cdd:COG2524  158 RDVVTVSEDDSLEEALRLMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206
CBS COG0517
CBS domain [Signal transduction mechanisms];
301-417 1.36e-07

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 50.25  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 301 TVSSIMTSrhDIEHIDLNAPEDEIRQLLERNQHTRLVVTDgdDAEDLLGVVHVIDLLQQSLRGEPLNLRVLIRQ-----P 375
Cdd:COG0517    2 KVKDIMTT--DVVTVSPDATVREALELMSEKRIGGLPVVD--EDGKLVGIVTDRDLRRALAAEGKDLLDTPVSEvmtrpP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 481041842 376 LVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDV 417
Cdd:COG0517   78 VTVSPDTSLEEAAELMEEHKIRRLPVVDDDGRLVGIITIKDL 119
COG2905 COG2905
Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains ...
 288-358 2.54e-06

Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains [Signal transduction mechanisms];


Pssm-ID: 442149 [Multi-domain]  Cd Length: 124  Bit Score: 46.75  E-value: 2.54e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 481041842 288 RRMIERVLNLNQRTVSSIMTSrhDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDdaeDLLGVVHVIDLLQ 358
Cdd:COG2905   53 RRVLAEGLDPLDTPVSEVMTR--PPITVSPDDSLAEALELMEEHRIRHLPVVDDG---KLVGIVSITDLLR 118
YtoI COG4109
Predicted transcriptional regulator containing CBS domains [Transcription];
301-417 3.21e-06

Predicted transcriptional regulator containing CBS domains [Transcription];


Pssm-ID: 443285 [Multi-domain]  Cd Length: 135  Bit Score: 46.44  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 301 TVSSIMTsRHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQQsLRGEPLNlRVLIRQPLVFPE 380
Cdd:COG4109   17 LVEDIMT-LEDVATLSEDDTVEDALELLEKTGHSRFPVVDENG--RLVGIVTSKDILGK-DDDTPIE-DVMTKNPITVTP 91

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 481041842 381 TLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDV 417
Cdd:COG4109   92 DTSLASAAHKMIWEGIELLPVVDDDGRLLGIISRQDV 128
CBS COG0517
CBS domain [Signal transduction mechanisms];
288-358 8.32e-06

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 45.24  E-value: 8.32e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 481041842 288 RRMIERVLNLNQRTVSSIMTsrHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQ 358
Cdd:COG0517   55 RALAAEGKDLLDTPVSEVMT--RPPVTVSPDTSLEEAAELMEEHKIRRLPVVDDDG--RLVGIITIKDLLK 121
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 370-423 2.90e-05

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 41.82  E-value: 2.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 481041842  370 VLIRQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAG 423
Cdd:pfam00571   4 IMTKDVVTVSPDTTLEEALELMREHGISRLPVVDEDGKLVGIVTLKDLLRALLG 57
COG2905 COG2905
Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains ...
 302-425 1.80e-04

Signal-transduction protein containing cAMP-binding, CBS, and nucleotidyltransferase domains [Signal transduction mechanisms];


Pssm-ID: 442149 [Multi-domain]  Cd Length: 124  Bit Score: 41.35  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 302 VSSIMTsrHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQQSLRGEPLNLRVLIRQ-----PL 376
Cdd:COG2905    1 VKDIMS--RDVVTVSPDATVREAARLMTEKGVGSLVVVDDDG--RLVGIITDRDLRRRVLAEGLDPLDTPVSEvmtrpPI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 481041842 377 VFPETLPLLPALEQFRNARTHFAFVVDEfGSVEGIVTLSDVTETIAGNL 425
Cdd:COG2905   77 TVSPDDSLAEALELMEEHRIRHLPVVDD-GKLVGIVSITDLLRALSEEL 124
CBS_pair_SIS_assoc cd04604
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ...
 288-358 4.58e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the with the SIS (Sugar ISomerase) domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the SIS (Sugar ISomerase) domain in the API [A5P (D-arabinose 5-phosphate) isomerase] protein KpsF/GutQ. These APIs catalyze the conversion of the pentose pathway intermediate D-ribulose 5-phosphate into A5P, a precursor of 3-deoxy-D-manno-octulosonate, which is an integral carbohydrate component of various glycolipids coating the surface of the outer membrane of Gram-negative bacteria, including lipopolysaccharide and many group 2 K-antigen capsules. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341378 [Multi-domain]  Cd Length: 124  Bit Score: 40.06  E-value: 4.58e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 481041842 288 RRMIERVLNLNQRTVSSIMTsrHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDAedLLGVVHVIDLLQ 358
Cdd:cd04604   58 RRALEKGLDILNLPAKDVMT--RNPKTISPDALAAEALELMEEHKITVLPVVDEDGK--PVGILHLHDLLR 124
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 302-357 9.06e-04

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 37.58  E-value: 9.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 481041842  302 VSSIMTsrHDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLL 357
Cdd:pfam00571   1 VKDIMT--KDVVTVSPDTTLEEALELMREHGISRLPVVDEDG--KLVGIVTLKDLL 52
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
287-358 1.54e-03

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 39.08  E-value: 1.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 481041842 287 ERRMIERVLNLNQRTVSSIMTSrhDIEHIDLNAPEDEIRQLLERNQHTRLVVTDGDDaeDLLGVVHVIDLLQ 358
Cdd:COG3448   60 PDRLDELEERLLDLPVEDVMTR--PVVTVTPDTPLEEAAELMLEHGIHRLPVVDDDG--RLVGIVTRTDLLR 127
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 373-459 3.00e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 37.61  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041842 373 RQPLVFPETLPLLPALEQFRNARTHFAFVVDEFGSVEGIVTLSDVTETIAGNLPNE---VEEIDARHDIqknadgswTAN 449
Cdd:cd02205    2 RDVVTVDPDTTVREALELMAENGIGALPVVDDDGKLVGIVTERDILRALVEGGLALdtpVAEVMTPDVI--------TVS 73

                         90
                 ....*....|
gi 481041842 450 GHMPLEDLVQ 459
Cdd:cd02205   74 PDTDLEEALE 83
CBS_pair_archHTH_assoc cd04588
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in archaea and ...
 397-459 5.16e-03

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in archaea and associated with helix turn helix domain; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key role in the regulation of cell proliferation and differentiation. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341364 [Multi-domain]  Cd Length: 111  Bit Score: 36.74  E-value: 5.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481041842 397 HFAFVVDEfGSVEGIVTLSDVTETIAGNLPNE-VEEIDARHDIqknadgswTANGHMPLEDLVQ 459
Cdd:cd04588   26 HGAPVVDD-GKLVGIVTLTDIAKALAEGKENAkVKDIMTKDVI--------TIDKDEKIYDAIR 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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