Ethanolamine utilization protein EutP, contains a P-loop NTPase domain [Amino acid transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481041832   1 MNHPVIGVVTKADLASmEQISLVTSWLREAGAHNVLVTSAVNNNGVTELFALLHTEEG 58
Cdd:COG4917   88 FNKPVIGVITKIDLPE-ADVERARKWLKSAGVEPIFIVSSVTGEGIEELKEYLEELGD 144

Ethanolamine utilization protein EutP, contains a P-loop NTPase domain [Amino acid transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481041832   1 MNHPVIGVVTKADLASmEQISLVTSWLREAGAHNVLVTSAVNNNGVTELFALLHTEEG 58
Cdd:COG4917   88 FNKPVIGVITKIDLPE-ADVERARKWLKSAGVEPIFIVSSVTGEGIEELKEYLEELGD 144

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 481041832   4 PVIgVVTKADLASMEQISLVTSWLREAGAhNVLVTSAVNNNGVTELFALLH 54
Cdd:cd01854   36 PVI-VLNKADLVDDEELEELLEIYEKLGY-PVLAVSAKTGEGLDELRELLK 84

Ethanolamine utilization protein EutP, contains a P-loop NTPase domain [Amino acid transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481041832   1 MNHPVIGVVTKADLASmEQISLVTSWLREAGAHNVLVTSAVNNNGVTELFALLHTEEG 58
Cdd:COG4917   88 FNKPVIGVITKIDLPE-ADVERARKWLKSAGVEPIFIVSSVTGEGIEELKEYLEELGD 144

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 481041832   4 PVIgVVTKADLASMEQISLVTSWLREAGAhNVLVTSAVNNNGVTELFALLH 54
Cdd:cd01854   36 PVI-VLNKADLVDDEELEELLEIYEKLGY-PVLAVSAKTGEGLDELRELLK 84

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 481041832   1 MNHPVIGVVTKADLASMEQISLVTSWLREAGAHN--VLVTSAVNNNGVTELFALL 53
Cdd:cd00882  105 EGIPIILVGNKIDLLEEREVEELLRLEELAKILGvpVFEVSAKTGEGVDELFEKL 159

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 481041832   4 PVIGVVTKADL----ASMEQI-SLVTSWLREAGAH--NVLVTSAVNNNGVTELFALLHTE 56
Cdd:cd01855   62 PVILVGNKIDLlpkdVKPNRLkQWVKKRLKIGGLKikDVILVSAKKGWGVEELIEEIKKL 121

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 481041832   4 PVIGVVTKADLASMEQISlvtswLREAGAHNVLVTSAVNNNGVTELFALL 53
Cdd:COG0486  321 PVIVVLNKIDLPSEADGE-----LKSLPGEPVIAISAKTGEGIDELKEAI 365

SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). It specifically recognizes the selenocysteine charged tRNAsec, which has a UCA anticodon, in an EF-Tu like manner. This allows insertion of selenocysteine at in-frame UGA stop codons. In E. coli SelB binds GTP, selenocysteyl-tRNAsec, and a stem-loop structure immediately downstream of the UGA codon (the SECIS sequence). The absence of active SelB prevents the participation of selenocysteyl-tRNAsec in translation. Archaeal and animal mechanisms of selenocysteine incorporation are more complex. Although the SECIS elements have different secondary structures and conserved elements between archaea and eukaryotes, they do share a common feature. Unlike in E. coli, these SECIS elements are located in the 3' UTRs. This group contains bacterial SelBs, as well as, one from archaea.

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                 ....*....|....*....|....*....|....*....|....*....|..
gi 481041832   8 VVTKADLASMEQISLVTS----WLREAGAHN--VLVTSAVNNNGVTELFALL 53
Cdd:cd04171  109 VLTKADLVDEDRLELVEEeileLLAGTFLADapIFPVSSVTGEGIEELKNYL 160