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Conserved domains on  [gi|447198782|ref|WP_001276038|]
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MULTISPECIES: ACR3 family arsenite efflux transporter [Salmonella]

Protein Classification

arsenic resistance protein( domain architecture ID 11435222)

arsenic resistance protein is a plasma membrane transporter that confers resistance to toxic metalloids (e.g.arsenite) by mediating extrusion of those compounds out of cells

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ACR3 COG0798
Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];
11-349 7.29e-137

Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];


:

Pssm-ID: 440561  Cd Length: 335  Bit Score: 392.19  E-value: 7.29e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  11 MNLFERYLSVWVALCIAIGILLGQVMPGVFRVIGGLEIARVNLPVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLF 90
Cdd:COG0798    5 LSFFERYLTLWIFLAMAAGLLLGYLFPGVFQALASLEVATVNIPIAILLWLMIYPMMAKVDFEELGKVFRNPKGLGLTLV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  91 INWLVKPFSMALLGWLFIRylfapwlpadQLDSYIAGLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFA 170
Cdd:COG0798   85 INWLIKPFLMFALAWLFLP----------DAPEYIAGLILLGLAPCTAMVIVWTGLAKGDVEYALVLVALNLLLQVLLFP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 171 PIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKALLR-KGQAAFDNALT-KIGPWSMAALLATLVLLFAFQGEA 248
Cdd:COG0798  155 PYVWLLLGVSDVTVPWGTLALSVLLYVVIPLAAGFLTRRLLLRrKGREWFEERFLpKLSPISLLGLLLTIVLLFALQGET 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 249 ILQQPLVIALLAVPILIQVLFNSALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGFHSGAALATVVGVLIE 328
Cdd:COG0798  235 ILENPLDILLIAIPLLIQFAINFALSYLLGRLLGLPYEDAAPLAFTGASNNFELALAVAIALFGLNSGAALATVVGPLIE 314
                        330       340
                 ....*....|....*....|.
gi 447198782 329 VPVMLLVVRVVNRSKGWYERA 349
Cdd:COG0798  315 VPVMLSLVKVALRTRKWFPKS 335
 
Name Accession Description Interval E-value
ACR3 COG0798
Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];
11-349 7.29e-137

Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];


Pssm-ID: 440561  Cd Length: 335  Bit Score: 392.19  E-value: 7.29e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  11 MNLFERYLSVWVALCIAIGILLGQVMPGVFRVIGGLEIARVNLPVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLF 90
Cdd:COG0798    5 LSFFERYLTLWIFLAMAAGLLLGYLFPGVFQALASLEVATVNIPIAILLWLMIYPMMAKVDFEELGKVFRNPKGLGLTLV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  91 INWLVKPFSMALLGWLFIRylfapwlpadQLDSYIAGLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFA 170
Cdd:COG0798   85 INWLIKPFLMFALAWLFLP----------DAPEYIAGLILLGLAPCTAMVIVWTGLAKGDVEYALVLVALNLLLQVLLFP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 171 PIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKALLR-KGQAAFDNALT-KIGPWSMAALLATLVLLFAFQGEA 248
Cdd:COG0798  155 PYVWLLLGVSDVTVPWGTLALSVLLYVVIPLAAGFLTRRLLLRrKGREWFEERFLpKLSPISLLGLLLTIVLLFALQGET 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 249 ILQQPLVIALLAVPILIQVLFNSALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGFHSGAALATVVGVLIE 328
Cdd:COG0798  235 ILENPLDILLIAIPLLIQFAINFALSYLLGRLLGLPYEDAAPLAFTGASNNFELALAVAIALFGLNSGAALATVVGPLIE 314
                        330       340
                 ....*....|....*....|.
gi 447198782 329 VPVMLLVVRVVNRSKGWYERA 349
Cdd:COG0798  315 VPVMLSLVKVALRTRKWFPKS 335
acr3 TIGR00832
arsenical-resistance protein; The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first ...
11-339 8.01e-117

arsenical-resistance protein; The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first protein of the ACR3 family functionally characterized was the ACR3 protein of Saccharomyces cerevisiae. It is present in the yeast plasma membrane and pumps arsenite out of the cell in response to the pmf. Similar proteins are found in bacteria, often as part of a four gene operon with an regulatory protein ArsR, a protein of unknown function ArsH, and an arsenate reductase that converts arsenate to arsenite to facilitate transport. [Cellular processes, Detoxification, Transport and binding proteins, Anions]


Pssm-ID: 213563  Cd Length: 328  Bit Score: 341.22  E-value: 8.01e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   11 MNLFERYLSVWVALCIAIGILLGQVMPGVFRVIGGLEIARVNLPVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLF 90
Cdd:TIGR00832   1 LSLLERYLTLWIFLAIAAGVGLGVLFPSVFQALAALEVATVSIPIAIGLILMMYPPLAKVDYSALGDVFKDPKGLILSLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   91 INWLVKPFSMALLGWLFIRYLFApwlpadqldsYIAGLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFA 170
Cdd:TIGR00832  81 INWIIGPFLMFLLAWLFLRDLFE----------YIAGLILLGLARCIAMVFVWNQLAKGDPEYTLVLVAVNSLFQVFLYA 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  171 PIVGLLLGLSSII-------VPWATLLTSVVLYIVVPVILAQLWRKALLR-KGQAAFDNALT-KIGPWSMAALLATLVLL 241
Cdd:TIGR00832 151 PLAWLLLGVSPIWlgltvitVPWETIAKSVLIYLGIPLIAGILTRYWLLKrKGREWYEKVFLpKISPWSLIALLFTIVLL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  242 FAFQGEAILQQPLVIALLAVPILIQVLFNSALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGFHSGAALAT 321
Cdd:TIGR00832 231 FAFQGETIIELPLDIALIAIPLLIYFYIMFFLTFALAKKLGLPYSITAPAAFTGASNNFELAIAVAISLFGLNSGAALAT 310
                         330
                  ....*....|....*...
gi 447198782  322 VVGVLIEVPVMLLVVRVV 339
Cdd:TIGR00832 311 VVGPLIEVPVMLSLVNVA 328
SBF pfam01758
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
57-252 5.80e-17

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


Pssm-ID: 366796  Cd Length: 191  Bit Score: 78.10  E-value: 5.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   57 LLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLFINWLVKPFSMALLGWLFIRYLFAPwlpadqlDSYIAGLILLAAAPC 136
Cdd:pfam01758   2 IGLFLMMFPMGLKVRYEDFKELFRRPKALLLGLLLQWVIMPLLMFLLAKFFLRDFPLP-------PELAVGLILVGCAPG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  137 TAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAF----APIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKALL 212
Cdd:pfam01758  75 GAMSNVWTYLAKGDVELSVVMVALSTLLAILFTplllYLLAGLLVEGTTLPVPIEEIAKSVLIYVIIPLIAGILTRYFLP 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 447198782  213 RKGQAAFdnaLTKIGPWSMAALLATLVLLFAFQGEAILQQ 252
Cdd:pfam01758 155 KHFESRI---LPAVPPISLIGLLLTIVVIFSLKGELIVSR 191
 
Name Accession Description Interval E-value
ACR3 COG0798
Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];
11-349 7.29e-137

Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism];


Pssm-ID: 440561  Cd Length: 335  Bit Score: 392.19  E-value: 7.29e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  11 MNLFERYLSVWVALCIAIGILLGQVMPGVFRVIGGLEIARVNLPVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLF 90
Cdd:COG0798    5 LSFFERYLTLWIFLAMAAGLLLGYLFPGVFQALASLEVATVNIPIAILLWLMIYPMMAKVDFEELGKVFRNPKGLGLTLV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  91 INWLVKPFSMALLGWLFIRylfapwlpadQLDSYIAGLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFA 170
Cdd:COG0798   85 INWLIKPFLMFALAWLFLP----------DAPEYIAGLILLGLAPCTAMVIVWTGLAKGDVEYALVLVALNLLLQVLLFP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 171 PIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKALLR-KGQAAFDNALT-KIGPWSMAALLATLVLLFAFQGEA 248
Cdd:COG0798  155 PYVWLLLGVSDVTVPWGTLALSVLLYVVIPLAAGFLTRRLLLRrKGREWFEERFLpKLSPISLLGLLLTIVLLFALQGET 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 249 ILQQPLVIALLAVPILIQVLFNSALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGFHSGAALATVVGVLIE 328
Cdd:COG0798  235 ILENPLDILLIAIPLLIQFAINFALSYLLGRLLGLPYEDAAPLAFTGASNNFELALAVAIALFGLNSGAALATVVGPLIE 314
                        330       340
                 ....*....|....*....|.
gi 447198782 329 VPVMLLVVRVVNRSKGWYERA 349
Cdd:COG0798  315 VPVMLSLVKVALRTRKWFPKS 335
acr3 TIGR00832
arsenical-resistance protein; The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first ...
11-339 8.01e-117

arsenical-resistance protein; The Arsenical Resistance-3 (ACR3) Family (TC 2.A.59) The first protein of the ACR3 family functionally characterized was the ACR3 protein of Saccharomyces cerevisiae. It is present in the yeast plasma membrane and pumps arsenite out of the cell in response to the pmf. Similar proteins are found in bacteria, often as part of a four gene operon with an regulatory protein ArsR, a protein of unknown function ArsH, and an arsenate reductase that converts arsenate to arsenite to facilitate transport. [Cellular processes, Detoxification, Transport and binding proteins, Anions]


Pssm-ID: 213563  Cd Length: 328  Bit Score: 341.22  E-value: 8.01e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   11 MNLFERYLSVWVALCIAIGILLGQVMPGVFRVIGGLEIARVNLPVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLF 90
Cdd:TIGR00832   1 LSLLERYLTLWIFLAIAAGVGLGVLFPSVFQALAALEVATVSIPIAIGLILMMYPPLAKVDYSALGDVFKDPKGLILSLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   91 INWLVKPFSMALLGWLFIRYLFApwlpadqldsYIAGLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFA 170
Cdd:TIGR00832  81 INWIIGPFLMFLLAWLFLRDLFE----------YIAGLILLGLARCIAMVFVWNQLAKGDPEYTLVLVAVNSLFQVFLYA 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  171 PIVGLLLGLSSII-------VPWATLLTSVVLYIVVPVILAQLWRKALLR-KGQAAFDNALT-KIGPWSMAALLATLVLL 241
Cdd:TIGR00832 151 PLAWLLLGVSPIWlgltvitVPWETIAKSVLIYLGIPLIAGILTRYWLLKrKGREWYEKVFLpKISPWSLIALLFTIVLL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  242 FAFQGEAILQQPLVIALLAVPILIQVLFNSALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGFHSGAALAT 321
Cdd:TIGR00832 231 FAFQGETIIELPLDIALIAIPLLIYFYIMFFLTFALAKKLGLPYSITAPAAFTGASNNFELAIAVAISLFGLNSGAALAT 310
                         330
                  ....*....|....*...
gi 447198782  322 VVGVLIEVPVMLLVVRVV 339
Cdd:TIGR00832 311 VVGPLIEVPVMLSLVNVA 328
SBF pfam01758
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
57-252 5.80e-17

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


Pssm-ID: 366796  Cd Length: 191  Bit Score: 78.10  E-value: 5.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   57 LLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLFINWLVKPFSMALLGWLFIRYLFAPwlpadqlDSYIAGLILLAAAPC 136
Cdd:pfam01758   2 IGLFLMMFPMGLKVRYEDFKELFRRPKALLLGLLLQWVIMPLLMFLLAKFFLRDFPLP-------PELAVGLILVGCAPG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  137 TAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAF----APIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKALL 212
Cdd:pfam01758  75 GAMSNVWTYLAKGDVELSVVMVALSTLLAILFTplllYLLAGLLVEGTTLPVPIEEIAKSVLIYVIIPLIAGILTRYFLP 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 447198782  213 RKGQAAFdnaLTKIGPWSMAALLATLVLLFAFQGEAILQQ 252
Cdd:pfam01758 155 KHFESRI---LPAVPPISLIGLLLTIVVIFSLKGELIVSR 191
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
21-341 4.15e-08

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 54.00  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782  21 WVALCIAIGILLGQVMPGVFRVIggleiarvnlpVGLLIWVMIIPMLLRIDFGALGQVKAHWRGIGVTLFINWLVKPFSM 100
Cdd:COG0385    2 WFLLLLLLAVVLALLLPAAFEPL-----------LPLLLALIMFGMGLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 101 ALLGWLFirylfapwlpadQLDSYIA-GLILLAAAPCTAMVFVWSRLTNGDPYFTLSQVALNDAIMIFAFAPIVGLLLGL 179
Cdd:COG0385   71 LALALLF------------GLPPELAlGLLLLAACPGGVASNVFTSLARGNVALSVSLTAVSTLLAPFLTPLLVALLLGL 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 180 SSIIVPWATLLTSVVLYIVVPVILAQLWRKALlrkgQAAFDNALTKIGPWSMAALLATLVLLFAFQGEAILQQPLVIALL 259
Cdd:COG0385  139 QGVEVDPLDMILSLLLIVLLPLVLGMLLRRLL----PKWAERLKKPLPLVSRLAILLIVYAAFAANVDNLLSVGLLVLLA 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782 260 AVPILIQVLfnsALAYGLNRLVGEKHNIACPSSLIGASNFFELAVAAAISLFGfHSGAALATVVGVLIEVPVMLLVVRVV 339
Cdd:COG0385  215 VLLLNALGL---LLGYLLARLLGLDRADRITIAFEVGMKNLGLALVLATTLFP-GPLAALPAALYHLWQLIVGALLARRW 290

                 ..
gi 447198782 340 NR 341
Cdd:COG0385  291 AR 292
SBF_like pfam13593
SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane ...
68-211 3.41e-05

SBF-like CPA transporter family (DUF4137); These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, pfam01758.


Pssm-ID: 433336  Cd Length: 313  Bit Score: 44.88  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447198782   68 LRIDFGALGQVKAHWRGIGVTLFINWLVKPFSMALLGWLFirylfAPWLPADQLDsyiaGLILLAAAPCT-AMVFVWSRL 146
Cdd:pfam13593  46 LRLSTEELLAGLRNWRLHLFVQLFTFVLFPLLGLGLSSLL-----PAALPPELLI----GFLLLAALPTTvSSSVAMTSQ 116
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447198782  147 TNGDPYFTLSQVALNDAIMIFAFAPIVGLLLGLSSIIVPWATLLTSVVLYIVVPVILAQLWRKAL 211
Cdd:pfam13593 117 AGGNVAAAVCNASIGNLLGVFLTPALVGLLLGGGGAGIDYGAVLKKLGLQVLLPLVLGQLLRPWF 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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